prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1cc(Cl)nnc1Cl)SNc1cc(Cl)ccc1C(=O)[O-]
|
O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl
|
O=C(Cc1cc(Cl)nnc1Cl)SNc1cc(Cl)ccc1C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCC(=O)c1cc(Cl)nnc1Cl)Nc1cc(Cl)ccc1C(=O)[O-]
|
O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl
|
O=C(CCCC(=O)c1cc(Cl)nnc1Cl)Nc1cc(Cl)ccc1C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)Nc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
|
O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl
|
CC(C)(CC(=O)Nc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)Nc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
|
O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl
|
CC(C)(CCC(=O)Nc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
|
O=C([O-])c1ccc(Cl)cc1NC(=O)c1cc(Cl)nnc1Cl
|
C[C@H](C(=O)SNc1cc(Cl)ccc1C(=O)[O-])c1cc(Cl)nnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C25=O"
}
|
Can you make molecule CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OCCC(C)C)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
|
CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
CC1=C(C(=O)OCCC(C)C)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OCCCCBr)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
|
CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
CC1=C(C(=O)OCCCCBr)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC3"
}
|
Can you make molecule CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
C=CCCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OCCCCCl)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
|
CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
CC1=C(C(=O)OCCCCCl)[C@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC3"
}
|
Can you make molecule CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
|
C=CCCCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](Cc1cc2cc(F)ccc2s1)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cc2cc(F)ccc2s1)[C@H]1CN2CCC[C@@H]2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(F)ccc2s1",
"old_substring": "c14cccc(F)c1F"
}
|
Can you make molecule [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(Br)cccc1C[C@H]([NH3+])[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
Cc1c(Br)cccc1C[C@H]([NH3+])[C@H]1CN2CCC[C@@H]2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c14cccc(F)c1F"
}
|
Can you make molecule [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](Cc1ccc(F)c(Cl)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1ccc(F)c(Cl)c1F)[C@H]1CN2CCC[C@@H]2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1F",
"old_substring": "c14cccc(F)c1F"
}
|
Can you make molecule [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](Cc1ccc(Cl)c(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1ccc(Cl)c(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(F)c1F",
"old_substring": "c14cccc(F)c1F"
}
|
Can you make molecule [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](Cc1cc(F)c(Br)cc1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
|
[NH3+][C@@H](Cc1cc(F)c(Br)cc1F)[C@H]1CN2CCC[C@@H]2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)c(Br)cc1F",
"old_substring": "c14cccc(F)c1F"
}
|
Can you make molecule CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(Cc2nc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)o2)c1C
|
CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C
|
CCn1nc(C)c(Cc2nc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)o2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1nc&oc1&",
"old_substring": "N46C"
}
|
Can you make molecule CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(Cc2cc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)s2)c1C
|
CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C
|
CCn1nc(C)c(Cc2cc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)s2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N46C"
}
|
Can you make molecule CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(Cc2ccc([C@@H]3CCCN(c4ccccc4)C3)c(C#N)c2)c1C
|
CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C
|
CCn1nc(C)c(Cc2ccc([C@@H]3CCCN(c4ccccc4)C3)c(C#N)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N46C"
}
|
Can you make molecule CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(CON=C2CCN([C@@H]3CCCN(c4ccccc4)C3)CC2)c1C
|
CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C
|
CCn1nc(C)c(CON=C2CCN([C@@H]3CCCN(c4ccccc4)C3)CC2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N46C"
}
|
Can you make molecule CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nc(C)c(Cc2cnc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)c2)c1C
|
CCn1nc(C)c(CN(C)[C@@H]2CCCN(c3ccccc3)C2)c1C
|
CCn1nc(C)c(Cc2cnc(C#N)c([C@@H]3CCCN(c4ccccc4)C3)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1ncc&cc1&",
"old_substring": "N46C"
}
|
Can you make molecule N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1(NC(=O)N[C@@H](c2ccccc2F)C2CCCC2)CCCCC1
|
N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
N#CC1(NC(=O)N[C@@H](c2ccccc2F)C2CCCC2)CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#CC1&CCCCC1",
"old_substring": "N#CCCCC4"
}
|
Can you make molecule N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)=NC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
CCCC(C)=NC(=O)N[C@@H](c1ccccc1F)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&C",
"old_substring": "N#CCCCC4"
}
|
Can you make molecule N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N[C@@H](c1ccccc1F)C1CCCC1)NN1CCCCCCCC1
|
N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
O=C(N[C@@H](c1ccccc1F)C1CCCC1)NN1CCCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N#CCCCC4"
}
|
Can you make molecule N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
C=CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "N#CCCCC4"
}
|
Can you make molecule N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCCCCCS)N[C@@H](c1ccccc1F)C1CCCC1
|
N#CCCCCNC(=O)N[C@@H](c1ccccc1F)C1CCCC1
|
O=C(NCCCCCCS)N[C@@H](c1ccccc1F)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCCC&",
"old_substring": "N#CCCCC4"
}
|
Can you make molecule CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CSC)[NH+]1CC=C(Cn2nc(-c3cccs3)[nH]c2=S)CC1
|
CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S
|
CC[C@@H](CSC)[NH+]1CC=C(Cn2nc(-c3cccs3)[nH]c2=S)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(C&)CC1",
"old_substring": "[NH+]3(C)C5"
}
|
Can you make molecule CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CSC)[NH+]1CC=C(CCn2nc(-c3cccs3)[nH]c2=S)CC1
|
CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S
|
CC[C@@H](CSC)[NH+]1CC=C(CCn2nc(-c3cccs3)[nH]c2=S)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(CC&)CC1",
"old_substring": "[NH+]3(C)C5"
}
|
Can you make molecule CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CSC)[NH+]1CCC(n2nc(-c3cccs3)[nH]c2=S)CC1
|
CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S
|
CC[C@@H](CSC)[NH+]1CCC(n2nc(-c3cccs3)[nH]c2=S)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "[NH+]3(C)C5"
}
|
Can you make molecule CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CSC)c1[nH+]c(C)nc(-n2nc(-c3cccs3)[nH]c2=S)c1C
|
CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S
|
CC[C@@H](CSC)c1[nH+]c(C)nc(-n2nc(-c3cccs3)[nH]c2=S)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]c(C)nc&c1C",
"old_substring": "[NH+]3(C)C5"
}
|
Can you make molecule CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CSC)c1n[nH+]c(-n2nc(-c3cccs3)[nH]c2=S)c(C)c1C
|
CC[C@@H](CSC)[NH+](C)Cn1nc(-c2cccs2)[nH]c1=S
|
CC[C@@H](CSC)c1n[nH+]c(-n2nc(-c3cccs3)[nH]c2=S)c(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH+]c&c(C)c1C",
"old_substring": "[NH+]3(C)C5"
}
|
Can you make molecule CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(C)c(Cl)c2)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(C)c(Cl)c2)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "c14ccccc1C"
}
|
Can you make molecule CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(Br)cc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(Br)cc2C)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1C",
"old_substring": "c14ccccc1C"
}
|
Can you make molecule CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2cccc(Br)c2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2cccc(Br)c2C)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c14ccccc1C"
}
|
Can you make molecule CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(F)cc2Cl)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccc(F)cc2Cl)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c14ccccc1C"
}
|
Can you make molecule CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2cc(F)ccc2Cl)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2ccccc2C)C[C@@H]1C
|
CCCC(=O)N1c2c(C)cccc2[C@@H](Nc2cc(F)ccc2Cl)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Cl",
"old_substring": "c14ccccc1C"
}
|
Can you make molecule Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CCCCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCCCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C4CC(N)=O"
}
|
Can you make molecule Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Cc1cc(C)nc([C@H]2CCC[NH+]2Cc2cccnc2)c1
|
Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
CC(=O)Cc1cc(C)nc([C@H]2CCC[NH+]2Cc2cccnc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(C)=O",
"old_substring": "C4CC(N)=O"
}
|
Can you make molecule Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)=NOc1cc(C)nc([C@H]2CCC[NH+]2Cc2cccnc2)c1
|
Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
CCC(CC)=NOc1cc(C)nc([C@H]2CCC[NH+]2Cc2cccnc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)=NO&",
"old_substring": "C4CC(N)=O"
}
|
Can you make molecule Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CCCC(N)=S)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCCC(N)=S)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(N)=S",
"old_substring": "C4CC(N)=O"
}
|
Can you make molecule Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CCCC/C(N)=N/O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCC(N)=O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
|
Cc1cc(CCCC/C(N)=N/O)cc([C@H]2CCC[NH+]2Cc2cccnc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC/C(N)=N/O",
"old_substring": "C4CC(N)=O"
}
|
Can you make molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)C[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN(C)C[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CN(C)C&",
"old_substring": "CN5"
}
|
Can you make molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@]1(CN=C=S)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
N#C[C@@]1(CN=C=S)CCC[C@H]1CCOc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N=C=S",
"old_substring": "CN5"
}
|
Can you make molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@]1(C2N=N2)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
N#C[C@@]1(C2N=N2)CCC[C@H]1CCOc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&N=N1",
"old_substring": "CN5"
}
|
Can you make molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C=N/O[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
C/C=N/O[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C=N/O&",
"old_substring": "CN5"
}
|
Can you make molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@]1(CC(N)=S)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
CN[C@]1(C#N)CCC[C@H]1CCOc1ccc2c(c1)OCO2
|
N#C[C@@]1(CC(N)=S)CCC[C@H]1CCOc1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "CN5"
}
|
Can you make molecule Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NSC3=CCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NSC3=CCCCCC3)cc2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C17CCCCCC1"
}
|
Can you make molecule Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCCCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCCCCCCC3)cc2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C17CCCCCC1"
}
|
Can you make molecule Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(C(=O)NCC(=O)N=CC3CCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)N=CC3CCCCCC3)cc2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1CCCCCC1",
"old_substring": "C17CCCCCC1"
}
|
Can you make molecule Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(CCC)=NC(=O)CNC(=O)c1ccc(-c2noc(C)n2)cc1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1
|
CCCC(CCC)=NC(=O)CNC(=O)c1ccc(-c2noc(C)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&CCC",
"old_substring": "C17CCCCCC1"
}
|
Can you make molecule Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(C)=NC(=O)CNC(=O)c1ccc(-c2noc(C)n2)cc1
|
Cc1nc(-c2ccc(C(=O)NCC(=O)NC3CCCCCC3)cc2)no1
|
CCCCCC(C)=NC(=O)CNC(=O)c1ccc(-c2noc(C)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC=&C",
"old_substring": "C17CCCCCC1"
}
|
Can you make molecule O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CCCCC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C13CC1"
}
|
Can you make molecule O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1SCCCS1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1SCCCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C13CC1"
}
|
Can you make molecule O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1SCSCS1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1SCSCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C13CC1"
}
|
Can you make molecule O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CCCCCC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C13CC1"
}
|
Can you make molecule O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CSCCSC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CC1
|
O[C@@H](CC[C@H]1Cc2ccccc21)C1CSCCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "C13CC1"
}
|
Can you make molecule COc1ccc(-c2c(C)nn(C)c2N)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COCc1ccc(-c2c(C)nn(C)c2N)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(-c2c(C)nn(C)c2N)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COCSc1ccc(-c2c(C)nn(C)c2N)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(-c2c(C)nn(C)c2N)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2c(C)nn(C)c2N)ccc1SC(C)=O
|
COc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COc1cc(-c2c(C)nn(C)c2N)ccc1SC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(-c2c(C)nn(C)c2N)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2c(C)nn(C)c2N)ccc1C(=O)CS
|
COc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COc1cc(-c2c(C)nn(C)c2N)ccc1C(=O)CS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(-c2c(C)nn(C)c2N)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2c(C)nn(C)c2N)ccc1C(=O)CI
|
COc1ccc(-c2c(C)nn(C)c2N)cc1OC
|
COc1cc(-c2c(C)nn(C)c2N)ccc1C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCCCN1S(=O)(=O)[C@@H]1CCC[NH2+]C1
|
C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C
|
C[C@@H]1CCCCCN1S(=O)(=O)[C@@H]1CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]1CCCCCN1&",
"old_substring": "C[C@@H]1CN3C[C@H]1C"
}
|
Can you make molecule C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC=CC[C@H]1S(=O)(=O)[C@@H]1CCC[NH2+]C1
|
C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C
|
C[C@H]1CC=CC[C@H]1S(=O)(=O)[C@@H]1CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CC=CC[C@H]1&",
"old_substring": "C[C@@H]1CN3C[C@H]1C"
}
|
Can you make molecule C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1SCCC[C@@H]1S(=O)(=O)[C@@H]1CCC[NH2+]C1
|
C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C
|
C[C@H]1SCCC[C@@H]1S(=O)(=O)[C@@H]1CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1SCCC[C@@H]1&",
"old_substring": "C[C@@H]1CN3C[C@H]1C"
}
|
Can you make molecule C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCCCN1S(=O)(=O)[C@@H]1CCC[NH2+]C1
|
C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C
|
C[C@H]1CCCCCN1S(=O)(=O)[C@@H]1CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCCCCN1&",
"old_substring": "C[C@@H]1CN3C[C@H]1C"
}
|
Can you make molecule C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCCl)S(=O)(=O)[C@@H]1CCC[NH2+]C1
|
C[C@@H]1CN(S(=O)(=O)[C@@H]2CCC[NH2+]C2)C[C@H]1C
|
C[C@H](CCCCl)S(=O)(=O)[C@@H]1CCC[NH2+]C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CCCCl",
"old_substring": "C[C@@H]1CN3C[C@H]1C"
}
|
Can you make molecule C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C1=C2CCN2CC(C(=O)C2CCC2)=NC(C2CC2)=N1)c1ccccc1F
|
C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1
|
C[C@H](C1=C2CCN2CC(C(=O)C2CCC2)=NC(C2CC2)=N1)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&nc&nc2C1",
"old_substring": "N234"
}
|
Can you make molecule C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C1=C2OCCN2CC(C(=O)C2CCC2)=CC(C2CC2)=C1)c1ccccc1F
|
C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1
|
C[C@H](C1=C2OCCN2CC(C(=O)C2CCC2)=CC(C2CC2)=C1)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2c&cc&cc2C1",
"old_substring": "N234"
}
|
Can you make molecule C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1ccccc1F)C1(C2CC2)CCN(C(=O)C2CCC2)C1
|
C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1
|
C[C@@H](c1ccccc1F)C1(C2CC2)CCN(C(=O)C2CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N234"
}
|
Can you make molecule C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1ccccc1F)C1(C2CC2)CCCN(C(=O)C2CCC2)C1
|
C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1
|
C[C@@H](c1ccccc1F)C1(C2CC2)CCCN(C(=O)C2CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N234"
}
|
Can you make molecule C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1ccccc1F)c1oc(C(=O)C2CCC2)c(C#N)c1C1CC1
|
C[C@@H](c1ccccc1F)N(C(=O)C1CCC1)C1CC1
|
C[C@@H](c1ccccc1F)c1oc(C(=O)C2CCC2)c(C#N)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N234"
}
|
Can you make molecule CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2(C)Cc3ccccc3C2)c1
|
CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2(C)Cc3ccccc3C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "CC2"
}
|
Can you make molecule CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2=CC3=CC=C3OC(C)(C)C2)c1
|
CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2=CC3=CC=C3OC(C)(C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)Cc2cc&ccc2O1",
"old_substring": "CC2"
}
|
Can you make molecule CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)N2CC(C)(C)Oc3ccccc32)c1
|
CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)N2CC(C)(C)Oc3ccccc32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2O1",
"old_substring": "CC2"
}
|
Can you make molecule CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)N2CC(C)(C)Sc3ccccc32)c1
|
CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)N2CC(C)(C)Sc3ccccc32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2S1",
"old_substring": "CC2"
}
|
Can you make molecule CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2C3CCC2CC3)c1
|
CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1
|
CNS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2ccccc2C)C2C3CCC2CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C2CCC1CC2",
"old_substring": "CC2"
}
|
Can you make molecule CCO[C@H](C)C(=O)OCC(=O)NC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@H](C)C(=O)OCCC(CO)=NC(C)C
|
CCO[C@H](C)C(=O)OCC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OCCC(CO)=NC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C5C2=O"
}
|
Can you make molecule CCO[C@H](C)C(=O)OCC(=O)NC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@H](C)C(=O)OC/C(C)=N\ONC(C)C
|
CCO[C@H](C)C(=O)OCC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OC/C(C)=N\ONC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C2=O"
}
|
Can you make molecule CCO[C@H](C)C(=O)OCC(=O)NC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@H](C)C(=O)OC(CC)(CC)C(=O)CNC(C)C
|
CCO[C@H](C)C(=O)OCC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OC(CC)(CC)C(=O)CNC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C2=O"
}
|
Can you make molecule CCO[C@H](C)C(=O)OCC(=O)NC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@H](C)C(=O)OSSC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OCC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OSSC(=O)NC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C2=O"
}
|
Can you make molecule CCO[C@H](C)C(=O)OCC(=O)NC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@H](C)C(=O)OC(CC)(CC)C(=O)CCNC(C)C
|
CCO[C@H](C)C(=O)OCC(=O)NC(C)C
|
CCO[C@H](C)C(=O)OC(CC)(CC)C(=O)CCNC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C2=O"
}
|
Can you make molecule C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccccc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccccc3)nc3ccccc23)[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c15cccnc1"
}
|
Can you make molecule C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccc(I)nc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccc(I)nc3)nc3ccccc23)[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)nc1",
"old_substring": "c15cccnc1"
}
|
Can you make molecule C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCN(C(=O)c2cc(-c3cc4cnsc4s3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cc4cnsc4s3)nc3ccccc23)[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cnsc2s1",
"old_substring": "c15cccnc1"
}
|
Can you make molecule C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(C(=O)N3CC[C@@H](C)C[C@@H]3C)c3ccccc3n2)c(C)n1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1
|
Cc1ccc(-c2cc(C(=O)N3CC[C@@H](C)C[C@@H]3C)c3ccccc3n2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)nc1C",
"old_substring": "c15cccnc1"
}
|
Can you make molecule C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccncc3Cl)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3cccnc3)nc3ccccc23)[C@@H](C)C1
|
C[C@@H]1CCN(C(=O)c2cc(-c3ccncc3Cl)nc3ccccc23)[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c15cccnc1"
}
|
Can you make molecule CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(Cl)(Cl)Cl)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(Cl)(Cl)Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C7(C)(C)C"
}
|
Can you make molecule CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)CC(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)CC(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)(C)CC(C)(C)C",
"old_substring": "C7(C)(C)C"
}
|
Can you make molecule CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCC(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCC(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C7(C)(C)C"
}
|
Can you make molecule CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCC(F)(F)F)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C7(C)(C)C"
}
|
Can you make molecule CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCCC(F)(F)F)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CCN(CCO)C(=O)N[C@H]1CC(=O)N(CCCCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C7(C)(C)C"
}
|
Can you make molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N=CCCC(C)=Nc1cc(NC(C)=O)ccc1F
|
CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F
|
CC(=O)N=CCCC(C)=Nc1cc(NC(C)=O)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCC=&C",
"old_substring": "C5CCC3=O"
}
|
Can you make molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CC(=O)Nc1cc(NC(C)=O)ccc1F)NC(C)=O
|
CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F
|
CCC[C@@H](CC(=O)Nc1cc(NC(C)=O)ccc1F)NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&=O",
"old_substring": "C5CCC3=O"
}
|
Can you make molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(NC(C)=O)C(=O)CNc1cc(NC(C)=O)ccc1F
|
CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F
|
CCC(CC)(NC(C)=O)C(=O)CNc1cc(NC(C)=O)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5CCC3=O"
}
|
Can you make molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(NC(C)=O)C(=O)CCNc1cc(NC(C)=O)ccc1F
|
CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F
|
CCC(CC)(NC(C)=O)C(=O)CCNc1cc(NC(C)=O)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5CCC3=O"
}
|
Can you make molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(F)c(N=C2CCC(NC(C)=O)CC2)c1
|
CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F
|
CC(=O)Nc1ccc(F)c(N=C2CCC(NC(C)=O)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC=&CC1",
"old_substring": "C5CCC3=O"
}
|
Can you make molecule CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCC(=O)[O-])SC(=O)Cc1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])SC(=O)Cc1cc(Cl)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCC(=O)[O-])C(=O)CCCC(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)CCCC(=O)c1cc(Cl)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCC(=O)[O-])C(=O)CC(C)(C)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)CC(C)(C)c1cc(Cl)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCC(=O)[O-])C(=O)CCC(C)(C)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)CCC(C)(C)c1cc(Cl)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCC(=O)[O-])SC(=O)[C@@H](C)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])C(=O)c1cc(Cl)ccc1F
|
CCN(CCC(=O)[O-])SC(=O)[C@@H](C)c1cc(Cl)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C25=O"
}
|
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