prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)Nc1ccsc1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1ccsc1)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccsc1",
"old_substring": "c13nccs1"
}
|
Can you make molecule C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)Nc1cnc(Br)s1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1cnc(Br)s1)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1ncc&s1",
"old_substring": "c13nccs1"
}
|
Can you make molecule C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Cl)s1",
"old_substring": "c13nccs1"
}
|
Can you make molecule C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)Nc1ncc(Br)s1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1ncc(Br)s1)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Br)s1",
"old_substring": "c13nccs1"
}
|
Can you make molecule C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)Nc1scnc1Cl)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1
|
C[C@@H](C(=O)Nc1scnc1Cl)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&scnc1Cl",
"old_substring": "c13nccs1"
}
|
Can you make molecule CCOC[C@H](O)CSC1COC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(O)c(C[C@H](O)CSC2COC2)c2onc1-2
|
CCOC[C@H](O)CSC1COC1
|
CCc1ccc(O)c(C[C@H](O)CSC2COC2)c2onc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC[C@H](O)CSC1COC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCOc2ccc(C[C@H](O)CSC3COC3)cc2C1
|
CCOC[C@H](O)CSC1COC1
|
CCN1CCOc2ccc(C[C@H](O)CSC3COC3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
}
|
Can you make molecule CCOC[C@H](O)CSC1COC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc2ccc-2ncn(C[C@H](O)CSC2COC2)c1=O
|
CCOC[C@H](O)CSC1COC1
|
CCc1cc2ccc-2ncn(C[C@H](O)CSC2COC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC[C@H](O)CSC1COC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc2nc-2ccn(C[C@H](O)CSC2COC2)c1=O
|
CCOC[C@H](O)CSC1COC1
|
CCc1ccc2nc-2ccn(C[C@H](O)CSC2COC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC[C@H](O)CSC1COC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cnc2nc-2ccn(C[C@H](O)CSC2COC2)c1=O
|
CCOC[C@H](O)CSC1COC1
|
CCc1cnc2nc-2ccn(C[C@H](O)CSC2COC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2ccccc2c1=O)C(=O)c1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)C(=O)c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)C&=O",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2ccccc2c1=O)N/N=C/Cc1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)N/N=C/Cc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/C&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCn1cnc2ccccc2c1=O)NOc1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1
|
O=C(CCCn1cnc2ccccc2c1=O)NOc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(CCC&)NO&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2ccccc2c1=O)N/N=C/CCc1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)N/N=C/CCc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/CC&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCC(=O)n1cnc2ccccc2c1=O)c1ccc(Cl)cc1
|
O=C(Cn1cnc2ccccc2c1=O)NNC(=O)c1ccc(Cl)cc1
|
O=C(CCC(=O)n1cnc2ccccc2c1=O)c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1)OC
|
CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CC[C@@H](CCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1)OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]23C"
}
|
Can you make molecule CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](CBr)CCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@@H](CBr)CCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]23C"
}
|
Can you make molecule CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](CBr)CCCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@@H](CBr)CCCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]23C"
}
|
Can you make molecule CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1=C(c2noc([C@H](C(C)C)[C@@H](C)[NH3+])n2)C=CC=C2C[C@H]2O1
|
CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
COC1=C(c2noc([C@H](C(C)C)[C@@H](C)[NH3+])n2)C=CC=C2C[C@H]2O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&Cc2cccc&c2O1",
"old_substring": "[C@H]23C"
}
|
Can you make molecule CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@H](CCl)CCCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@H](C)c1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
|
CO[C@H](CCl)CCCc1noc([C@H](C(C)C)[C@@H](C)[NH3+])n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]23C"
}
|
Can you make molecule NC(=O)c1ccc([N+](=O)[O-])s1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)CCCc1ccc([N+](=O)[O-])s1
|
NC(=O)c1ccc([N+](=O)[O-])s1
|
NC(=O)CCCc1ccc([N+](=O)[O-])s1
| 102
|
{
"fragment_index": 0,
"new_substring": "NC(=O)CCC&",
"old_substring": "NC2=O"
}
|
Can you make molecule NC(=O)c1ccc([N+](=O)[O-])s1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CCCN(c2ccc([N+](=O)[O-])s2)C1
|
NC(=O)c1ccc([N+](=O)[O-])s1
|
O=C1CCCN(c2ccc([N+](=O)[O-])s2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(=O)C1",
"old_substring": "NC2=O"
}
|
Can you make molecule NC(=O)c1ccc([N+](=O)[O-])s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1ccc([N+](=O)[O-])s1
|
NC(=O)c1ccc([N+](=O)[O-])s1
|
CCC(=O)c1ccc([N+](=O)[O-])s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "NC2=O"
}
|
Can you make molecule NC(=O)c1ccc([N+](=O)[O-])s1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=CC1CCN(c2ccc([N+](=O)[O-])s2)CC1
|
NC(=O)c1ccc([N+](=O)[O-])s1
|
O=CC1CCN(c2ccc([N+](=O)[O-])s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC(C=O)CC1",
"old_substring": "NC2=O"
}
|
Can you make molecule NC(=O)c1ccc([N+](=O)[O-])s1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CSC(=S)N1c1ccc([N+](=O)[O-])s1
|
NC(=O)c1ccc([N+](=O)[O-])s1
|
O=C1CSC(=S)N1c1ccc([N+](=O)[O-])s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&C(=O)CSC1=S",
"old_substring": "NC2=O"
}
|
Can you make molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3Cl)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3Cl)cnn21)Nc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccc(I)cc3)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccc(I)cc3)cnn21)Nc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cnn3c2NC(=O)[C@H]3CC(=O)Nc2cccc(F)c2)cc1I
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1
|
Cc1ccc(-c2cnn3c2NC(=O)[C@H]3CC(=O)Nc2cccc(F)c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1C(=O)Nc2c(-c3cccc(Br)c3)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1
|
O=C(C[C@@H]1C(=O)Nc2c(-c3cccc(Br)c3)cnn21)Nc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(-c2cnn3c2NC(=O)[C@H]3CC(=O)Nc2cccc(F)c2)c1C
|
O=C(C[C@@H]1C(=O)Nc2c(-c3ccccc3)cnn21)Nc1cccc(F)c1
|
Cc1cccc(-c2cnn3c2NC(=O)[C@H]3CC(=O)Nc2cccc(F)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c16ccccc1"
}
|
Can you make molecule Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)cc(S(=O)(=O)N(C)CCCC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CCCC[NH+](C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C2C3"
}
|
Can you make molecule Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)cc(S(=O)(=O)N(C)CCCCC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CCCCC[NH+](C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C2C3"
}
|
Can you make molecule Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)cc(S(=O)(=O)N(C)C2CC([NH+](C)C)C2)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)C2CC([NH+](C)C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C2C3"
}
|
Can you make molecule Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)cc(S(=O)(=O)N(C)[C@@H](C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)[C@@H](C)CC[NH+](C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C2C3"
}
|
Can you make molecule Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)cc(S(=O)(=O)N(C)C2CCC([NH+](C)C)CC2)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)CC[NH+](C)C)c1
|
Cc1cc(F)cc(S(=O)(=O)N(C)C2CCC([NH+](C)C)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C2C3"
}
|
Can you make molecule CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@H]1CCC[NH+]1C1(C)Cc2ccccc2C1)S(=O)(=O)c1cccc(C[NH3+])c1
|
CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1
|
CN(C[C@H]1CCC[NH+]1C1(C)Cc2ccccc2C1)S(=O)(=O)c1cccc(C[NH3+])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "CC2"
}
|
Can you make molecule CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@H]1CCC[NH+]1C1=CC2=CC=C2OC(C)(C)C1)S(=O)(=O)c1cccc(C[NH3+])c1
|
CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1
|
CN(C[C@H]1CCC[NH+]1C1=CC2=CC=C2OC(C)(C)C1)S(=O)(=O)c1cccc(C[NH3+])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)Cc2cc&ccc2O1",
"old_substring": "CC2"
}
|
Can you make molecule CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@H]1CCC[NH+]1N1CC(C)(C)Oc2ccccc21)S(=O)(=O)c1cccc(C[NH3+])c1
|
CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1
|
CN(C[C@H]1CCC[NH+]1N1CC(C)(C)Oc2ccccc21)S(=O)(=O)c1cccc(C[NH3+])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2O1",
"old_substring": "CC2"
}
|
Can you make molecule CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@H]1CCC[NH+]1N1CC(C)(C)Sc2ccccc21)S(=O)(=O)c1cccc(C[NH3+])c1
|
CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1
|
CN(C[C@H]1CCC[NH+]1N1CC(C)(C)Sc2ccccc21)S(=O)(=O)c1cccc(C[NH3+])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2S1",
"old_substring": "CC2"
}
|
Can you make molecule CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@H]1CCC[NH+]1C1C2CCC1CC2)S(=O)(=O)c1cccc(C[NH3+])c1
|
CC[NH+]1CCC[C@@H]1CN(C)S(=O)(=O)c1cccc(C[NH3+])c1
|
CN(C[C@H]1CCC[NH+]1C1C2CCC1CC2)S(=O)(=O)c1cccc(C[NH3+])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C2CCC1CC2",
"old_substring": "CC2"
}
|
Can you make molecule COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)cc1I
|
COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1
|
COc1cc(OC)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c15cc6cc9c1"
}
|
Can you make molecule COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)cc1Cl
|
COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1
|
COc1cc(OC)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c15cc6cc9c1"
}
|
Can you make molecule COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(I)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)c1
|
COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1
|
COc1cc(I)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c15cc6cc9c1"
}
|
Can you make molecule COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)c1
|
COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1
|
COc1cc(Br)c(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Br)c1",
"old_substring": "c15cc6cc9c1"
}
|
Can you make molecule COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)cc1Br
|
COc1cc(OC)cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c1
|
COc1cc(-c2onc(C)c2C(=O)NC2Cc3ccccc3C2)c(OC)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1&",
"old_substring": "c15cc6cc9c1"
}
|
Can you make molecule Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nc(C(=O)NC[C@@H](C)C(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@@H](C)C(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](C)C&=O",
"old_substring": "C5[C@@H]7O"
}
|
Can you make molecule Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nc(C(=O)NCC[C@H](C)CC(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NCC[C@H](C)CC(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C5[C@@H]7O"
}
|
Can you make molecule Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nc(C(=O)NC[C@@H](O)C(C)(C)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@@H](O)C(C)(C)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](O)C&(C)C",
"old_substring": "C5[C@@H]7O"
}
|
Can you make molecule Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CC(=O)c1ccccc1)NC(=O)c1cc2c([nH]c3ccccc32)c(-c2ccc(C)cc2)n1
|
Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
CC[C@H](CC(=O)c1ccccc1)NC(=O)c1cc2c([nH]c3ccccc32)c(-c2ccc(C)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H]&CC&=O",
"old_substring": "C5[C@@H]7O"
}
|
Can you make molecule Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2nc(C(=O)NC(=O)C[C@H](C)C(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC[C@H](O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
|
Cc1ccc(-c2nc(C(=O)NC(=O)C[C@H](C)C(=O)c3ccccc3)cc3c2[nH]c2ccccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&=O)C&=O",
"old_substring": "C5[C@@H]7O"
}
|
Can you make molecule O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncncc2I)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncncc2I)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncncc1I",
"old_substring": "c14ncccn1"
}
|
Can you make molecule O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ccnc(Br)n2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ccnc(Br)n2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1nccc&n1",
"old_substring": "c14ncccn1"
}
|
Can you make molecule O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncc(Br)cn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncc(Br)cn2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Br)cn1",
"old_substring": "c14ncccn1"
}
|
Can you make molecule O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncncc2Cl)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncncc2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncncc1Cl",
"old_substring": "c14ncccn1"
}
|
Can you make molecule O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncc3ccccn23)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncccn2)CC1
|
O=C(c1nc(-c2ccc(Cl)cc2)n2c1CCCCC2)N1CCN(c2ncc3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc2ccccn12",
"old_substring": "c14ncccn1"
}
|
Can you make molecule CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
C=CSn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CSc2nc3ccccc3n2C(C)C)cc1
|
CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
COc1ccc(C(=O)CSc2nc3ccccc3n2C(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
C=CCCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CSc2nc3ccccc3n2CCCCl)cc1
|
CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
COc1ccc(C(=O)CSc2nc3ccccc3n2CCCCl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CSc2nc3ccccc3n2CCCCS)cc1
|
CCn1c(SCC(=O)c2ccc(OC)cc2)nc2ccccc21
|
COc1ccc(C(=O)CSc2nc3ccccc3n2CCCCS)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC6"
}
|
Can you make molecule Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C)c([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1nc(C)c([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc(C)c&o1",
"old_substring": "Cc1nnc6o1"
}
|
Can you make molecule Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c(C)o1
|
Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1nc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c(C)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc&c(C)o1",
"old_substring": "Cc1nnc6o1"
}
|
Can you make molecule Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c1C
|
Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1noc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1noc&c1C",
"old_substring": "Cc1nnc6o1"
}
|
Can you make molecule Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nscc1[C@H]1Cc2ccccc2CN1Cc1ccc(Cl)c(F)c1
|
Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1nscc1[C@H]1Cc2ccccc2CN1Cc1ccc(Cl)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nscc1&",
"old_substring": "Cc1nnc6o1"
}
|
Can you make molecule Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c(C)c1C
|
Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1
|
Cc1nn([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)c(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nn&c(C)c1C",
"old_substring": "Cc1nnc6o1"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)c(OC)cc1I
|
COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)c(OC)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c15ccc9cc16"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)c(OC)cc1Cl
|
COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)c(OC)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c15ccc9cc16"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)cc(I)c1OC
|
COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1cc(CCNC(=O)c2cccc3c2NC(=O)C3)cc(I)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c15ccc9cc16"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(OC)c(CCNC(=O)c2cccc3c2NC(=O)C3)c1
|
COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1cc(Br)c(OC)c(CCNC(=O)c2cccc3c2NC(=O)C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Br)c1",
"old_substring": "c15ccc9cc16"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1ccc(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
|
COc1cc(Br)c(CCNC(=O)c2cccc3c2NC(=O)C3)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1&",
"old_substring": "c15ccc9cc16"
}
|
Can you make molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N2CCCN(C(=O)[C@@H]3CC[C@@H](c4ccccc4C)C3)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3CC[C@@H](c4ccccc4C)C3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]16C[C@@H]17"
}
|
Can you make molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N2CCCN(C(=O)[C@H]3C=C[C@@H](c4ccccc4C)C3)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@H]3C=C[C@@H](c4ccccc4C)C3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[C@@H]16C[C@@H]17"
}
|
Can you make molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N2CCCN(C(=O)[C@H]3C=C[C@H](c4ccccc4C)C3)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@H]3C=C[C@H](c4ccccc4C)C3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[C@@H]16C[C@@H]17"
}
|
Can you make molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N2CCCN(C(=O)[C@H]3CCC[C@H](c4ccccc4C)C3)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@H]3CCC[C@H](c4ccccc4C)C3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@@H]16C[C@@H]17"
}
|
Can you make molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(N2CCCN(C(=O)[C@H]3CCCC[C@H](c4ccccc4C)C3)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1
|
Cc1csc(N2CCCN(C(=O)[C@H]3CCCC[C@H](c4ccccc4C)C3)CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]16C[C@@H]17"
}
|
Can you make molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2Cl)c(C)c1CC(=O)SN[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1CC(=O)SN[C@H]1CCCCNC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)CCCC(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)CCCC(=O)N[C@H]1CCCCNC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(C)(C)CC(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(C)(C)CC(=O)N[C@H]1CCCCNC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(C)(C)CCC(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(C)(C)CCC(=O)N[C@H]1CCCCNC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2Cl)c(C)c1[C@H](C)C(=O)SN[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)N[C@H]1CCCCNC1=O
|
Cc1nn(Cc2ccccc2Cl)c(C)c1[C@H](C)C(=O)SN[C@H]1CCCCNC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
O=C(/C=C/Sc1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(N2CCO[C@H](Cc3cccc(F)c3)C2)nc1-c1c[nH]cn1
|
O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
O=Cc1sc(N2CCO[C@H](Cc3cccc(F)c3)C2)nc1-c1c[nH]cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(N2CCO[C@H](Cc3cccc(F)c3)C2)sc1-c1c[nH]cn1
|
O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
O=Cc1nc(N2CCO[C@H](Cc3cccc(F)c3)C2)sc1-c1c[nH]cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N1CCO[C@H](Cc2cccc(F)c2)C1)n1nc(-c2c[nH]cn2)oc1=S
|
O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
O=C(N1CCO[C@H](Cc2cccc(F)c2)C1)n1nc(-c2c[nH]cn2)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1cccc(C[C@@H]2CN(O/N=C/c3ccc(-c4c[nH]cn4)o3)CCO2)c1
|
O=C(c1c[nH]cn1)N1CCO[C@H](Cc2cccc(F)c2)C1
|
Fc1cccc(C[C@@H]2CN(O/N=C/c3ccc(-c4c[nH]cn4)o3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C34"
}
|
Can you make molecule Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)cc1I
|
Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccccc12"
}
|
Can you make molecule Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)cc1Cl
|
Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccccc12"
}
|
Can you make molecule Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1cc(I)ccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1ccccc12"
}
|
Can you make molecule Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)c1
|
Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1ccc(I)c([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccccc12"
}
|
Can you make molecule Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)sc2cc-2c1
|
Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
Cc1ccc([C@@H]2C[C@@H]2/C([O-])=N/S(=O)(=O)c2cccc([N+](=O)[O-])c2)sc2cc-2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&cc2c1",
"old_substring": "Cc1ccccc12"
}
|
Can you make molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(C(=O)NCc2ccco2)cc1NSC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NSC(=O)Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CCCC(=O)c1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CCCC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CC(C)(C)c1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CC(C)(C)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(C(=O)NCc2ccco2)cc1NC[S@+]([O-])CCCc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC[S@+]([O-])CCCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CCC(C)(C)c1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1
|
Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)CCC(C)(C)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2ccc(O)c(CC)c3onc2-3)=C1CC
|
CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2ccc(O)c(CC)c3onc2-3)=C1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)N2CCOc3ccc(CC)cc3C2)=C1CC
|
CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)N2CCOc3ccc(CC)cc3C2)=C1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2cc3ccc-3ncn(CC)c2=O)=C1CC
|
CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2cc3ccc-3ncn(CC)c2=O)=C1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2ccc3nc-3ccn(CC)c2=O)=C1CC
|
CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2ccc3nc-3ccn(CC)c2=O)=C1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2cnc3nc-3ccn(CC)c2=O)=C1CC
|
CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1
|
CCOC(=O)[C@@H]1C(C)=NC(C(=O)c2cnc3nc-3ccn(CC)c2=O)=C1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O24"
}
|
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