prompt stringlengths 120 209 | completion stringlengths 15 103 | input_smiles stringlengths 14 103 | output_smiles stringlengths 15 103 | task_id int64 102 102 | winner_action dict |
|---|---|---|---|---|---|
Can you make molecule Cc1ccsc1CNC(=O)CCCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1CCCCNC(=O)CCCC[NH3+] | Cc1ccsc1CNC(=O)CCCC[NH3+] | Cc1ccsc1CCCCNC(=O)CCCC[NH3+] | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C34"
} |
Can you make molecule Cc1ccsc1CNC(=O)CCCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1CCC=NC(=O)CCCC[NH3+] | Cc1ccsc1CNC(=O)CCCC[NH3+] | Cc1ccsc1CCC=NC(=O)CCCC[NH3+] | 102 | {
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C34"
} |
Can you make molecule Cc1ccsc1CNC(=O)CCCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1CCCCCNC(=O)CCCC[NH3+] | Cc1ccsc1CNC(=O)CCCC[NH3+] | Cc1ccsc1CCCCCNC(=O)CCCC[NH3+] | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C34"
} |
Can you make molecule Cc1ccsc1CNC(=O)CCCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1C1CC(NC(=O)CCCC[NH3+])C1 | Cc1ccsc1CNC(=O)CCCC[NH3+] | Cc1ccsc1C1CC(NC(=O)CCCC[NH3+])C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C34"
} |
Can you make molecule Cc1ccsc1CNC(=O)CCCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1SC(=S)ONC(=O)CCCC[NH3+] | Cc1ccsc1CNC(=O)CCCC[NH3+] | Cc1ccsc1SC(=S)ONC(=O)CCCC[NH3+] | 102 | {
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C34"
} |
Can you make molecule C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@]1(SCNC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(SCNC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N34"
} |
Can you make molecule C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@]1(C2CN(C(=O)CNc3cc(F)cc(F)c3)C2)CCS(=O)(=O)C1 | C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(C2CN(C(=O)CNc3cc(F)cc(F)c3)C2)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CC&C1",
"old_substring": "N34"
} |
Can you make molecule C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@]1(SC(=N)NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(SC(=N)NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N34"
} |
Can you make molecule C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@]1(c2snc(C(=O)CNc3cc(F)cc(F)c3)c2N)CCS(=O)(=O)C1 | C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | C[C@]1(c2snc(C(=O)CNc3cc(F)cc(F)c3)c2N)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N34"
} |
Can you make molecule C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CN(C(=O)CNc1cc(F)cc(F)c1)C(=S)S[C@@]1(C)CCS(=O)(=O)C1 | C[C@]1(NC(=O)CNc2cc(F)cc(F)c2)CCS(=O)(=O)C1 | CN(C(=O)CNc1cc(F)cc(F)c1)C(=S)S[C@@]1(C)CCS(=O)(=O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N34"
} |
Can you make molecule C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule. | CCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 | CCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "C6CCO"
} |
Can you make molecule C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule. | C=C=CO[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 | C=C=CO[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=C=CO&",
"old_substring": "C6CCO"
} |
Can you make molecule C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule. | CCCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 | CCCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "C6CCO"
} |
Can you make molecule C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule. | C=CCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 | C=CCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=CCC&=O",
"old_substring": "C6CCO"
} |
Can you make molecule C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule. | CCCCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | C[C@H](NC(=O)[C@H](C)N1CC[NH+](CCCO)CC1)c1ccc2c(c1)CCCC2 | CCCCC(=O)[NH+]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "C6CCO"
} |
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCCCC4)ncn3)CC2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N18CCCCC1"
} |
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCCCCC4)ncn3)CC2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N18CCCCC1"
} |
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCC(C)(C)C4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCC(C)(C)C4)ncn3)CC2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)C1",
"old_substring": "N18CCCCC1"
} |
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCC(C)(C)CC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCC(C)(C)CC4)ncn3)CC2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)CC1",
"old_substring": "N18CCCCC1"
} |
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)N2CCN(c3cc(N4CC5(CCCCC5)C4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CCCCC4)ncn3)CC2)cc1Cl | Cc1ccc(NC(=O)N2CCN(c3cc(N4CC5(CCCCC5)C4)ncn3)CC2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "N1&CC2(CCCCC2)C1",
"old_substring": "N18CCCCC1"
} |
Can you make molecule C=C(C)Cn1ccc(-c2ccsc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(C)Cn1ccc(-c2cc(C)c(C)s2)n1 | C=C(C)Cn1ccc(-c2ccsc2)n1 | C=C(C)Cn1ccc(-c2cc(C)c(C)s2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&sc1C",
"old_substring": "c14ccsc1"
} |
Can you make molecule C=C(C)Cn1ccc(-c2ccsc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(C)Cn1ccc(-c2cc(C)sc2C)n1 | C=C(C)Cn1ccc(-c2ccsc2)n1 | C=C(C)Cn1ccc(-c2cc(C)sc2C)n1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(C)sc1C",
"old_substring": "c14ccsc1"
} |
Can you make molecule C=C(C)Cn1ccc(-c2ccsc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(C)Cn1ccc(-c2sccc2Br)n1 | C=C(C)Cn1ccc(-c2ccsc2)n1 | C=C(C)Cn1ccc(-c2sccc2Br)n1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c14ccsc1"
} |
Can you make molecule C=C(C)Cn1ccc(-c2ccsc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(C)Cn1ccc(-c2cc3sccc3s2)n1 | C=C(C)Cn1ccc(-c2ccsc2)n1 | C=C(C)Cn1ccc(-c2cc3sccc3s2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc2sccc2s1",
"old_substring": "c14ccsc1"
} |
Can you make molecule C=C(C)Cn1ccc(-c2ccsc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | C=C(C)Cn1ccc(-c2cc(Cl)sc2Cl)n1 | C=C(C)Cn1ccc(-c2ccsc2)n1 | C=C(C)Cn1ccc(-c2cc(Cl)sc2Cl)n1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(Cl)sc1Cl",
"old_substring": "c14ccsc1"
} |
Can you make molecule CC(C)[C@@H](C)NC(=O)CSCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](C)C1=NC2=C(CN(C(=O)CSCC[NH3+])C1)S2 | CC(C)[C@@H](C)NC(=O)CSCC[NH3+] | CC(C)[C@@H](C)C1=NC2=C(CN(C(=O)CSCC[NH3+])C1)S2 | 102 | {
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N12"
} |
Can you make molecule CC(C)[C@@H](C)NC(=O)CSCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](C)N1CCCN(C(=O)CSCC[NH3+])C2=CC2=N1 | CC(C)[C@@H](C)NC(=O)CSCC[NH3+] | CC(C)[C@@H](C)N1CCCN(C(=O)CSCC[NH3+])C2=CC2=N1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N12"
} |
Can you make molecule CC(C)[C@@H](C)NC(=O)CSCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](C)C1=CC2=CC=C2N(C(=O)CSCC[NH3+])CC1 | CC(C)[C@@H](C)NC(=O)CSCC[NH3+] | CC(C)[C@@H](C)C1=CC2=CC=C2N(C(=O)CSCC[NH3+])CC1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N12"
} |
Can you make molecule CC(C)[C@@H](C)NC(=O)CSCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](C)C1=NC2=C(CN(C(=O)CSCC[NH3+])CC1)O2 | CC(C)[C@@H](C)NC(=O)CSCC[NH3+] | CC(C)[C@@H](C)C1=NC2=C(CN(C(=O)CSCC[NH3+])CC1)O2 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCc2nc&oc2C1",
"old_substring": "N12"
} |
Can you make molecule CC(C)[C@@H](C)NC(=O)CSCC[NH3+] less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](C)C1=CC=C2C=C2N(C(=O)CSCC[NH3+])CCS1 | CC(C)[C@@H](C)NC(=O)CSCC[NH3+] | CC(C)[C@@H](C)C1=CC=C2C=C2N(C(=O)CSCC[NH3+])CCS1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "N12"
} |
Can you make molecule CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule. | CCN(SC(=O)C[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(SC(=O)C[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
} |
Can you make molecule CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC(=C=O)C[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(CC(=C=O)C[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C36=O"
} |
Can you make molecule CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule. | CCN(C(=O)CCCC(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)CCCC(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
} |
Can you make molecule CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule. | CCN(C(=O)CC(C)(C)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)CC(C)(C)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
} |
Can you make molecule CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule. | CCN(C[S@+]([O-])CCC[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | CCN(C[S@+]([O-])CCC[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C36=O"
} |
Can you make molecule C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(=O)NON1CC[C@@H](O)C1 | C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 | CCC(=O)NON1CC[C@@H](O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H]&C(=O)NO&",
"old_substring": "C[C@@H]([NH3+])C2=O"
} |
Can you make molecule C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC[C@H](C)CC(=O)N1CC[C@@H](O)C1 | C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 | CC[C@H](C)CC(=O)N1CC[C@@H](O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@@H]([NH3+])C2=O"
} |
Can you make molecule C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC[C@H](C)CN1CC[C@@H](O)C1 | C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 | CC[C@H](C)CN1CC[C@@H](O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@@H]([NH3+])C2=O"
} |
Can you make molecule C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](C=O)N(C)ON1CC[C@@H](O)C1 | C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 | C[C@@H](C=O)N(C)ON1CC[C@@H](O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H](C&=O)N(C)O&",
"old_substring": "C[C@@H]([NH3+])C2=O"
} |
Can you make molecule C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(=O)NON1CC[C@@H](O)C1 | C[C@@H]([NH3+])C(=O)N1CC[C@@H](O)C1 | CCC(=O)NON1CC[C@@H](O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]&C(=O)NO&",
"old_substring": "C[C@@H]([NH3+])C2=O"
} |
Can you make molecule Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NSC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NSC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C5(=O)C8"
} |
Can you make molecule Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)CCCC(=O)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)CCCC(=O)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C5(=O)C8"
} |
Can you make molecule Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)CC(C)(C)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)CC(C)(C)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C5(=O)C8"
} |
Can you make molecule Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC[S@+]([O-])CCCc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC[S@+]([O-])CCCc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C5(=O)C8"
} |
Can you make molecule Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(NC(=O)CCC(C)(C)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)Cc2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | Cc1ccc(NC(=O)CCC(C)(C)c2ccc(NC3=N[C@H]4CS(=O)(=O)C[C@H]4S3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C5(=O)C8"
} |
Can you make molecule Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)sc1C | Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1cc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)sc1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&sc1C",
"old_substring": "Cc1cnc7s1"
} |
Can you make molecule Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccsc1C=NC(=O)Cc1csc(NC(=O)c2ccc3c(c2)OCO3)n1 | Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1ccsc1C=NC(=O)Cc1csc(NC(=O)c2ccc3c(c2)OCO3)n1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccsc1C=&",
"old_substring": "Cc1cnc7s1"
} |
Can you make molecule Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C=NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1ccc(C=NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc(C=&)s1",
"old_substring": "Cc1cnc7s1"
} |
Can you make molecule Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(Br)c(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1cc(Br)c(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc(Br)c&s1",
"old_substring": "Cc1cnc7s1"
} |
Can you make molecule Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc2sc(NC(=O)Cc3csc(NC(=O)c4ccc5c(c4)OCO5)n3)nc2c1 | Cc1cnc(NC(=O)Cc2csc(NC(=O)c3ccc4c(c3)OCO4)n2)s1 | Cc1ccc2sc(NC(=O)Cc3csc(NC(=O)c4ccc5c(c4)OCO5)n3)nc2c1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&nc2c1",
"old_substring": "Cc1cnc7s1"
} |
Can you make molecule CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)c1cccc(NC(=O)COc2ccc(C(Cl)(Cl)Cl)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(Cl)(Cl)Cl)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C9(C)(C)C"
} |
Can you make molecule CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(C)(C)CC(C)(C)C",
"old_substring": "C9(C)(C)C"
} |
Can you make molecule CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCC(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCC(C)(C)C)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C9(C)(C)C"
} |
Can you make molecule CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCC(F)(F)F)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCC(F)(F)F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C9(C)(C)C"
} |
Can you make molecule CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCCC(F)(F)F)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 | CNC(=O)c1cccc(NC(=O)COc2ccc(CCCCC(F)(F)F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C9(C)(C)C"
} |
Can you make molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](CCc1nnc2n1CC[NH+](Cc1ccc(OC)c(OC)c1)CC2)NC(=O)C(C)C | COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC | CC[C@@H](CCc1nnc2n1CC[NH+](Cc1ccc(OC)c(OC)c1)CC2)NC(=O)C(C)C | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]89C"
} |
Can you make molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C[NH+]2CCc3nnc(CC[C@H](CBr)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc(CC[C@H](CBr)NC(=O)C(C)C)n3CC2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]89C"
} |
Can you make molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C[NH+]2CCc3nnc(CCC[C@H](CBr)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc(CCC[C@H](CBr)NC(=O)C(C)C)n3CC2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]89C"
} |
Can you make molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C[NH+]2CCc3nnc(CCC[C@@H](CCl)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc(CCC[C@@H](CCl)NC(=O)C(C)C)n3CC2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]89C"
} |
Can you make molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C[NH+]2CCc3nnc([C@H]4CCC[C@H](NC(=O)C(C)C)C4)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC | COc1ccc(C[NH+]2CCc3nnc([C@H]4CCC[C@H](NC(=O)C(C)C)C4)n3CC2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]89C"
} |
Can you make molecule Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(Cl)cc(Cl)c1OCC(=O)N/N=C/c1ccc(Br)o1 | Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 | Cc1cc(Cl)cc(Cl)c1OCC(=O)N/N=C/c1ccc(Br)o1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc(Cl)cc(Cl)c1&",
"old_substring": "Cc1cc4c(C)c(C)c1"
} |
Can you make molecule Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(C)cc1Br | Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 | Cc1cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(C)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1Br",
"old_substring": "Cc1cc4c(C)c(C)c1"
} |
Can you make molecule Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(Br)c(C)c1Cl | Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 | Cc1cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(Br)c(C)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(Br)c(C)c1Cl",
"old_substring": "Cc1cc4c(C)c(C)c1"
} |
Can you make molecule Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(Br)cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(C)c1C | Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 | Cc1c(Br)cc(OCC(=O)N/N=C/c2ccc(Br)o2)c(C)c1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c(Br)cc&c(C)c1C",
"old_substring": "Cc1cc4c(C)c(C)c1"
} |
Can you make molecule Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(COc1cc(Cl)ccc1Cl)N/N=C/c1ccc(Br)o1 | Cc1cc(C)c(C)c(OCC(=O)N/N=C/c2ccc(Br)o2)c1 | O=C(COc1cc(Cl)ccc1Cl)N/N=C/c1ccc(Br)o1 | 102 | {
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "Cc1cc4c(C)c(C)c1"
} |
Can you make molecule CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc(CC(=O)SN2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(CC(=O)SN2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
} |
Can you make molecule CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc(C(=O)CCCC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)CCCC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
} |
Can you make molecule CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc(C(C)(C)CC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(C)(C)CC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
} |
Can you make molecule CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc(C(C)(C)CCC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(C)(C)CCC(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
} |
Can you make molecule CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc([C@H](C)C(=O)SN2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc(C(=O)N2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | CCc1cc([C@H](C)C(=O)SN2CC[C@](O)(CN3CCOCC3)C(C)(C)C2)cc(=O)[nH]1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
} |
Can you make molecule CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(F)(F)CN2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(F)(F)CN2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&CC(F)(F)CN1",
"old_substring": "[C@@H]18CC(=O)N(C)C1"
} |
Can you make molecule CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC)c1ccc(NC(=O)[C@]2(C)CC(C)=NO2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@]2(C)CC(C)=NO2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@]1&(C)CC(C)=NO1",
"old_substring": "[C@@H]18CC(=O)N(C)C1"
} |
Can you make molecule CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(Cl)=NO2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(Cl)=NO2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&CC(Cl)=NO1",
"old_substring": "[C@@H]18CC(=O)N(C)C1"
} |
Can you make molecule CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC)c1ccc(NC(=O)[C@@H]2C=C(O)N=N2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2C=C(O)N=N2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&C=C(O)N=N1",
"old_substring": "[C@@H]18CC(=O)N(C)C1"
} |
Can you make molecule CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCN(CC)c1ccc(NC(=O)[C@H]2CSC(=O)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@@H]2CC(=O)N(C)C2)cc1 | CCN(CC)c1ccc(NC(=O)[C@H]2CSC(=O)C2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CSC(=O)C1",
"old_substring": "[C@@H]18CC(=O)N(C)C1"
} |
Can you make molecule CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](CNC(=O)CC(C)(C)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)CC(C)(C)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
} |
Can you make molecule CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](CNC(=O)CCC(C)(C)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)CCC(C)(C)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
} |
Can you make molecule CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(NC[C@@H](C(C)C)N2CC[NH+](C)CC2)c(=O)n(N[C@H]2C[C@@H]2C)n1C | CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | Cc1c(NC[C@@H](C(C)C)N2CC[NH+](C)CC2)c(=O)n(N[C@H]2C[C@@H]2C)n1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C23=O"
} |
Can you make molecule CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)c(NC[C@@H](C(C)C)N2CC[NH+](C)CC2)nn1N[C@H]1C[C@@H]1C | CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | Cc1cc(=O)c(NC[C@@H](C(C)C)N2CC[NH+](C)CC2)nn1N[C@H]1C[C@@H]1C | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C23=O"
} |
Can you make molecule CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@H](CNC(=O)C[C@@H](Br)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | CC(C)[C@H](CNC(=O)C[C@@H](Br)N[C@H]1C[C@@H]1C)N1CC[NH+](C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
} |
Can you make molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule. | C/[NH+]=C(/NCCCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C2C5"
} |
Can you make molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule. | C/[NH+]=C(/N=CCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/N=CCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C2C5"
} |
Can you make molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule. | C/[NH+]=C(/NCCCCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCCCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C2C5"
} |
Can you make molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule. | C/[NH+]=C(\NCc1ncc(C)s1)NC1CC(c2cc(C)cc(C)c2)C1 | C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(\NCc1ncc(C)s1)NC1CC(c2cc(C)cc(C)c2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C2C5"
} |
Can you make molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 less soluble in water? The output molecule should be similar to the input molecule. | C/[NH+]=C(/N=C(C)CCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | C/[NH+]=C(/N=C(C)CCc1cc(C)cc(C)c1)NCc1ncc(C)s1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C2C5"
} |
Can you make molecule CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)C1=C(N=C([O-])C2=NN(c3cc(C)ccc3C)C(=O)CC2)CCS1 | CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC(=O)C1=C(N=C([O-])C2=NN(c3cc(C)ccc3C)C(=O)CC2)CCS1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C1=C(N&)CCS1",
"old_substring": "C3(=O)C=4C#N"
} |
Can you make molecule CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CNC(=O)C(N=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1)=C(Cl)Cl | CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC(=O)C(N=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1)=C(Cl)Cl | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(N&)=C(Cl)Cl",
"old_substring": "C3(=O)C=4C#N"
} |
Can you make molecule CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CN=C/C=C/N=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CN=C/C=C/N=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C=&/C=C/N&",
"old_substring": "C3(=O)C=4C#N"
} |
Can you make molecule CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CNSC(=O)C=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNSC(=O)C=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C=4C#N"
} |
Can you make molecule CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CNC[S@+]([O-])CCC=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC(=O)C(C#N)=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | CNC[S@+]([O-])CCC=C([O-])C1=NN(c2cc(C)ccc2C)C(=O)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C=4C#N"
} |
Can you make molecule CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)s1 | CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 | CCc1ccc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)s1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&s1",
"old_substring": "c17nc8cs1"
} |
Can you make molecule CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1sc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)nc1Cl | CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 | CCc1sc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)nc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&sc&nc1Cl",
"old_substring": "c17nc8cs1"
} |
Can you make molecule CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1nc2c(COC(=O)c3cc(-c4ccc(Br)cc4)n[nH]3)cccc2s1 | CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 | CCc1nc2c(COC(=O)c3cc(-c4ccc(Br)cc4)n[nH]3)cccc2s1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&nc2c&cccc2s1",
"old_substring": "c17nc8cs1"
} |
Can you make molecule CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1nccc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)c1I | CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 | CCc1nccc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)c1I | 102 | {
"fragment_index": 0,
"new_substring": "c1&nccc&c1I",
"old_substring": "c17nc8cs1"
} |
Can you make molecule CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)sc1Br | CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1 | CCc1cc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)sc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&sc1Br",
"old_substring": "c17nc8cs1"
} |
Can you make molecule CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCC[C@@H](CCc1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | CCCC[C@@H](CCc1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "CCC[C@H]37"
} |
Can you make molecule CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCC[C@@](C)(Cc1nnnn1C[C@@H]1CCCO1)C[NH+]1CCN(c2cc(C)ccc2C)CC1 | CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | CCC[C@@](C)(Cc1nnnn1C[C@@H]1CCCO1)C[NH+]1CCN(c2cc(C)ccc2C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC[C@](C)(C&)C&",
"old_substring": "CCC[C@H]37"
} |
Can you make molecule CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C)c(N2CC[NH+]([C@@H](CCc3nnnn3C[C@@H]3CCCO3)C(C)(C)C)CC2)c1 | CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | Cc1ccc(C)c(N2CC[NH+]([C@@H](CCc3nnnn3C[C@@H]3CCCO3)C(C)(C)C)CC2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "CCC[C@H]37"
} |
Can you make molecule CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C)c(N2CC[NH+]([C@H]3CCCC[C@H](c4nnnn4C[C@@H]4CCCO4)C3)CC2)c1 | CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | Cc1ccc(C)c(N2CC[NH+]([C@H]3CCCC[C@H](c4nnnn4C[C@@H]4CCCO4)C3)CC2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "CCC[C@H]37"
} |
Can you make molecule CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C)c(N2CC[NH+]([C@H]3CCC[C@H](c4nnnn4C[C@@H]4CCCO4)CC3)CC2)c1 | CCC[C@@H](c1nnnn1C[C@@H]1CCCO1)[NH+]1CCN(c2cc(C)ccc2C)CC1 | Cc1ccc(C)c(N2CC[NH+]([C@H]3CCC[C@H](c4nnnn4C[C@@H]4CCCO4)CC3)CC2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "CCC[C@H]37"
} |
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