prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
|
CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1
|
CC(C)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "CC[C@@H]46"
}
|
Can you make molecule CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
|
CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1
|
CCC[C@@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "CC[C@@H]46"
}
|
Can you make molecule CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCC=NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)Cc1ccccc1
|
CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1
|
C[C@H](CCC=NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "CC[C@@H]46"
}
|
Can you make molecule CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCC1=CCC[C@@H]1c1ccccc1)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
|
CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1
|
O=C(NCCC1=CCC[C@@H]1c1ccccc1)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC1=CCC[C@@H]1&",
"old_substring": "CC[C@@H]46"
}
|
Can you make molecule CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
|
CC[C@@H](NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12)c1ccccc1
|
CCCC[C@@H](CCc1ccccc1)NC(=O)c1cc(-c2ccccn2)nc2ccc(Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "CC[C@@H]46"
}
|
Can you make molecule Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(Br)cc1CC(=O)SNc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1CC(=O)SNc1cc(Cl)c(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(Br)cc1C(=O)CCCC(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(=O)CCCC(=O)Nc1cc(Cl)c(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(Br)cc1C(C)(C)CC(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(C)(C)CC(=O)Nc1cc(Cl)c(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(Br)cc1C(C)(C)CCC(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1
|
Cn1cc(Br)cc1C(C)(C)CCC(=O)Nc1cc(Cl)c(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNc1cc(Cl)c(Cl)cn1)c1cc(Br)cn1C
|
Cn1cc(Br)cc1C(=O)Nc1cc(Cl)c(Cl)cn1
|
C[C@H](C(=O)SNc1cc(Cl)c(Cl)cn1)c1cc(Br)cn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COCc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COCSc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
CC(=O)Sc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
O=C(CS)c1ccc(NS(=O)(=O)CCc2ccccc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1
|
O=C(CI)c1ccc(NS(=O)(=O)CCc2ccccc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1I
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)ccc1Br
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1
|
CCCc1cc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1Cl
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)c1Br
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1
|
CCCc1cccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)c1Cl
|
CCCc1ccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)cc1
|
CCCc1cccc(C(=O)N[C@@H](C)c2cccc(S(=O)(=O)NC)c2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCOC(=O)Nc1cc(Cl)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc2c(c1)CN(C(=O)Nc1cc(Cl)ccc1OC)CCO2
|
CCOC(=O)Nc1cc(Cl)ccc1OC
|
CCc1ccc2c(c1)CN(C(=O)Nc1cc(Cl)ccc1OC)CCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)Nc1cc(Cl)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2ccc-2cc(C(=O)Nc2cc(Cl)ccc2OC)c1=O
|
CCOC(=O)Nc1cc(Cl)ccc1OC
|
CCn1cnc2ccc-2cc(C(=O)Nc2cc(Cl)ccc2OC)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)Nc1cc(Cl)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ccc2nc-2ccc(C(=O)Nc2cc(Cl)ccc2OC)c1=O
|
CCOC(=O)Nc1cc(Cl)ccc1OC
|
CCn1ccc2nc-2ccc(C(=O)Nc2cc(Cl)ccc2OC)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)Nc1cc(Cl)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc2oc(C(=O)Nc3cc(Cl)ccc3OC)c(C=O)c2c1
|
CCOC(=O)Nc1cc(Cl)ccc1OC
|
CCc1ccc2oc(C(=O)Nc3cc(Cl)ccc3OC)c(C=O)c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O24"
}
|
Can you make molecule CCOC(=O)Nc1cc(Cl)ccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCSC(=S)OC(=O)Nc1cc(Cl)ccc1OC
|
CCOC(=O)Nc1cc(Cl)ccc1OC
|
CCSC(=S)OC(=O)Nc1cc(Cl)ccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O24"
}
|
Can you make molecule C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2csc(NSC(=O)Cc3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NSC(=O)Cc3cccnc3)n2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2csc(NC(=O)CCCC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)CCCC(=O)c3cccnc3)n2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2csc(NC(=O)CC(C)(C)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)CC(C)(C)c3cccnc3)n2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2csc(NC(=O)CCC(C)(C)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H]1CN(Cc2csc(NC(=O)CCC(C)(C)c3cccnc3)n2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNc1nc(CN2C[C@H](C)O[C@@H](C)C2)cs1)c1cccnc1
|
C[C@H]1CN(Cc2csc(NC(=O)c3cccnc3)n2)C[C@H](C)O1
|
C[C@H](C(=O)SNc1nc(CN2C[C@H](C)O[C@@H](C)C2)cs1)c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(CCCCO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CCCCO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C35"
}
|
Can you make molecule Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(CCCCCO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CCCCCO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C35"
}
|
Can you make molecule Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C2CC(O[C@@H]3CCC[C@@H]([NH3+])C3)C2)c1Cl
|
Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(C2CC(O[C@@H]3CCC[C@@H]([NH3+])C3)C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C35"
}
|
Can you make molecule Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(SC(=S)OO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(SC(=S)OO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C35"
}
|
Can you make molecule Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(NC(=S)SO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(CO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
|
Cc1nn(C)c(NC(=S)SO[C@@H]2CCC[C@@H]([NH3+])C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C35"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nn2c(C(C)(C)C)nnc2s1
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nn2c(C(C)(C)C)nnc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nn2c&nnc2s1",
"old_substring": "c17nnnn16"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nn(C(C)(C)C)nc1C
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COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C
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COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nn(C(C)(C)C)nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nn&nc1C",
"old_substring": "c17nnnn16"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nc2ncnn12
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nc2ncnn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2ncnn12",
"old_substring": "c17nnnn16"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nn2cnnc12
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nn2cnnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nn2cnnc12",
"old_substring": "c17nnnn16"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nc2nncn12
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1nnnn1C(C)(C)C
|
COc1ccc(C)cc1NC(=O)[C@@H](C)Sc1cc(C(C)(C)C)nc2nncn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2nncn12",
"old_substring": "c17nnnn16"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(c1cc2cc(F)ccc2s1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
O=C(c1cc2cc(F)ccc2s1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(F)ccc2s1",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(Br)cccc1C(=O)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
Cc1c(Br)cccc1C(=O)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N2CCSC23CCN(S(=O)(=O)c2cccc4ccccc24)CC3)oc2ccc(F)cc12
|
O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
Cc1c(C(=O)N2CCSC23CCN(S(=O)(=O)c2cccc4ccccc24)CC3)oc2ccc(F)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccc(F)cc2c1C",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(c1cc(F)ccc1Br)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
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O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
O=C(c1cc(F)ccc1Br)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(c1ccc(F)cc1Cl)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
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O=C(c1cccc(F)c1)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
|
O=C(c1ccc(F)cc1Cl)N1CCSC12CCN(S(=O)(=O)c1cccc3ccccc13)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnnc1CNC(=O)CC(C)(C)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNC(=O)CC(C)(C)NC[C@H](O)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
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CCn1cnnc1CNC(=O)CCC(C)(C)NC[C@H](O)c1ccccc1OC
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CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNC(=O)CCC(C)(C)NC[C@H](O)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnnc1CNc1c(C)n(C)n(NC[C@H](O)c2ccccc2OC)c1=O
|
CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNc1c(C)n(C)n(NC[C@H](O)c2ccccc2OC)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C23=O"
}
|
Can you make molecule CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
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CCn1cnnc1CNc1nn(NC[C@H](O)c2ccccc2OC)c(C)cc1=O
|
CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNc1nn(NC[C@H](O)c2ccccc2OC)c(C)cc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C23=O"
}
|
Can you make molecule CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnnc1CNC(=O)C[C@@H](Br)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNC(=O)NC[C@H](O)c1ccccc1OC
|
CCn1cnnc1CNC(=O)C[C@@H](Br)NC[C@H](O)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](NSC(=O)Cc1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NSC(=O)Cc1csc(C#CCCO)c1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](NC(=O)CCCC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)CCCC(=O)c1csc(C#CCCO)c1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](NC(=O)CC(C)(C)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)CC(C)(C)c1csc(C#CCCO)c1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](NC(=O)CCC(C)(C)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)CCC(C)(C)c1csc(C#CCCO)c1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](NSC(=O)[C@@H](C)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NC(=O)c1csc(C#CCCO)c1)c1cccs1
|
CC[C@@H](NSC(=O)[C@@H](C)c1csc(C#CCCO)c1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN(SC(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(SC(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN(C(=O)CCCC(=O)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)CCCC(=O)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN(C(=O)CC(C)(C)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)CC(C)(C)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN(C[S@+]([O-])CCCc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C[S@+]([O-])CCCc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN(C(=O)CCC(C)(C)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
|
C=CCN(C(=O)CCC(C)(C)c1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2Cl)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccc(I)cc2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccc(I)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@H](O)C(=O)N2CCCN(c3ccccc3C)CC2)cc1I
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1
|
Cc1ccc([C@H](O)C(=O)N2CCCN(c3ccccc3C)CC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2cccc(Br)c2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2cccc(Br)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2cccc(C)c2C)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2ccccc2)CC1
|
Cc1ccccc1N1CCCN(C(=O)[C@@H](O)c2cccc(C)c2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C[NH+]1CCC(CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
|
Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1
|
Cc1ccccc1C[NH+]1CCC(CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "[NH+]45C"
}
|
Can you make molecule Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1CC[NH+]1CCC(CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
|
Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1
|
Cc1ccccc1CC[NH+]1CCC(CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "[NH+]45C"
}
|
Can you make molecule Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C[NH+]1CC=C(CCC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
|
Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1
|
Cc1ccccc1C[NH+]1CC=C(CCC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(C&)CC1",
"old_substring": "[NH+]45C"
}
|
Can you make molecule Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C[NH+]1Cc2cc(CC(=O)Nc3cccc(S(=O)(=O)/N=C4\CCCN4)c3)sc2C1
|
Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1
|
Cc1ccccc1C[NH+]1Cc2cc(CC(=O)Nc3cccc(S(=O)(=O)/N=C4\CCCN4)c3)sc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&Cc2cc&sc2C1",
"old_substring": "[NH+]45C"
}
|
Can you make molecule Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C[NH+]1CCC[C@H](CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
|
Cc1ccccc1C[NH+](C)CC(=O)Nc1cccc(S(=O)(=O)/N=C2\CCCN2)c1
|
Cc1ccccc1C[NH+]1CCC[C@H](CC(=O)Nc2cccc(S(=O)(=O)/N=C3\CCCN3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@H]&CC1",
"old_substring": "[NH+]45C"
}
|
Can you make molecule CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C[C@H]3C)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C[C@H]3C)nnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC[C@H]&C[C@H]1C",
"old_substring": "N14CC[C@H]9C1"
}
|
Can you make molecule CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c2ccccc2n2c(CN3CCCC[C@@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CCCC[C@@H](C[NH+](C)CC)C3)nnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC[C@@H]&C1",
"old_substring": "N14CC[C@H]9C1"
}
|
Can you make molecule CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c2ccccc2n2c(CN3CCC[C@H](C[NH+](C)CC)CC3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CCC[C@H](C[NH+](C)CC)CC3)nnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@H]&CC1",
"old_substring": "N14CC[C@H]9C1"
}
|
Can you make molecule CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c2ccccc2n2c(CCC3=N[C@H](C[NH+](C)CC)SC3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CCC3=N[C@H](C[NH+](C)CC)SC3)nnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=N[C@H]&SC1",
"old_substring": "N14CC[C@H]9C1"
}
|
Can you make molecule CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c2ccccc2n2c(CCC3=N[C@@H](C[NH+](C)CC)SC3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CN3CC[C@H](C[NH+](C)CC)C3)nnc12
|
CCn1c(=O)c2ccccc2n2c(CCC3=N[C@@H](C[NH+](C)CC)SC3)nnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=N[C@@H]&SC1",
"old_substring": "N14CC[C@H]9C1"
}
|
Can you make molecule CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CC(C)(C)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)CC(C)(C)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)CCC(C)(C)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)CCC(C)(C)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN(C(=O)C[C@@H](Br)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
CC(C)CN(C(=O)C[C@@H](Br)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N(CC(C)C)C2CC2)cc(=O)n1NCc1ccc(S(=O)(=O)N(C)C)cc1
|
CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
Cc1cc(N(CC(C)C)C2CC2)cc(=O)n1NCc1ccc(S(=O)(=O)N(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N(CC(C)C)C2CC2)c(=O)ccn1NCc1ccc(S(=O)(=O)N(C)C)cc1
|
CC(C)CN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CC1
|
Cc1c(N(CC(C)C)C2CC2)c(=O)ccn1NCc1ccc(S(=O)(=O)N(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2I)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2I)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)NCCCC(=O)N1CCC(c2cc(C(F)(F)F)ccc2Br)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2cc(C(F)(F)F)ccc2Br)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2Cl)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)NCCCC(=O)N1CCC(c2cccc(C(F)(F)F)c2Br)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2cccc(C(F)(F)F)c2Br)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)NCCCC(=O)N1CCC(c2cccc(C(F)(F)F)c2Cl)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2ccc(C(F)(F)F)cc2)CC1
|
COC(=O)NCCCC(=O)N1CCC(c2cccc(C(F)(F)F)c2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)c1c(NC(=O)COc2cc(C)ccc2C)sc2c1CCCC2
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1
|
CC(=O)c1c(NC(=O)COc2cc(C)ccc2C)sc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)=O",
"old_substring": "C8(N)=O"
}
|
Can you make molecule Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CCCCC(N)=O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CCCCC(N)=O)CCCC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C8(N)=O"
}
|
Can you make molecule Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC/C(N)=N/O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC/C(N)=N/O)CCCC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C8(N)=O"
}
|
Can you make molecule Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC/C(N)=N\O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC/C(N)=N\O)CCCC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C8(N)=O"
}
|
Can you make molecule Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC(N)=S)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2C(N)=O)CCCC3)c1
|
Cc1ccc(C)c(OCC(=O)Nc2sc3c(c2CC(N)=S)CCCC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "C8(N)=O"
}
|
Can you make molecule COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COCCCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COCCCCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CC([NH+]2CCC[C@H](NC(=O)C=Cc3ccnc(Cl)c3)C2)C1
|
COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COC1CC([NH+]2CCC[C@H](NC(=O)C=Cc3ccnc(Cl)c3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C4C5"
}
|
Can you make molecule COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
CO[C@@H](C)CC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CCC([NH+]2CCC[C@H](NC(=O)C=Cc3ccnc(Cl)c3)C2)CC1
|
COCC[NH+]1CCC[C@H](NC(=O)C=Cc2ccnc(Cl)c2)C1
|
COC1CCC([NH+]2CCC[C@H](NC(=O)C=Cc3ccnc(Cl)c3)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C4C5"
}
|
Can you make molecule O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1Cl
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c18ccccc1"
}
|
Can you make molecule O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccc(I)cc1
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccc(I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(CCc2ccccc2)C(=O)c2ccc(N3CCOC3=O)cc2)cc1I
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1
|
Cc1ccc(CN(CCc2ccccc2)C(=O)c2ccc(N3CCOC3=O)cc2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c18ccccc1"
}
|
Can you make molecule O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1cccc(Br)c1
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CN(CCc2ccccc2)C(=O)c2ccc(N3CCOC3=O)cc2)c1C
|
O=C(c1ccc(N2CCOC2=O)cc1)N(CCc1ccccc1)Cc1ccccc1
|
Cc1cccc(CN(CCc2ccccc2)C(=O)c2ccc(N3CCOC3=O)cc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c18ccccc1"
}
|
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