prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1cccc(Cl)c1
|
CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1cccc(Cl)c1",
"old_substring": "C1=5C=Cc2ccccc21"
}
|
Can you make molecule CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=Cc1ccc(N(C)C)c(F)c1)c1ccc(C)cc1
|
CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F
|
CCC(=Cc1ccc(N(C)C)c(F)c1)c1ccc(C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&c1ccc(C)cc1",
"old_substring": "C1=5C=Cc2ccccc21"
}
|
Can you make molecule CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1ccc(Cl)cc1
|
CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1ccc(Cl)cc1",
"old_substring": "C1=5C=Cc2ccccc21"
}
|
Can you make molecule CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1cccc2ccccc12
|
CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F
|
CC(=Cc1ccc(N(C)C)c(F)c1)c1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1cccc2ccccc12",
"old_substring": "C1=5C=Cc2ccccc21"
}
|
Can you make molecule CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=Cc1ccc(N(C)C)c(F)c1)c1cccc(Cl)c1
|
CN(C)c1ccc(C=C2C=Cc3ccccc32)cc1F
|
CCC(=Cc1ccc(N(C)C)c(F)c1)c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&c1cccc(Cl)c1",
"old_substring": "C1=5C=Cc2ccccc21"
}
|
Can you make molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)[C@H](NC(=O)CC(C)(C)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)CC(C)(C)N1CCCCC1)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)[C@H](NC(=O)CCC(C)(C)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)CCC(C)(C)N1CCCCC1)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)[C@H](NC(=O)C[C@@H](Br)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)C[C@@H](Br)N1CCCCC1)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)[C@H](Nc1cc(C)n(N2CCCCC2)c(=O)c1)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](Nc1cc(C)n(N2CCCCC2)c(=O)c1)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)[C@H](Nc1c(C)n(N2CCCCC2)ccc1=O)C(=O)[O-]
|
CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-]
|
CC[C@H](C)[C@H](Nc1c(C)n(N2CCCCC2)ccc1=O)C(=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule C=CC(=O)NCOCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)N1CCOC2=CC=C2C=C(CC(C)C)C1
|
C=CC(=O)NCOCC(C)C
|
C=CC(=O)N1CCOC2=CC=C2C=C(CC(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "N1CO2"
}
|
Can you make molecule C=CC(=O)NCOCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)N1CCOC2=CC=C2C=C(CC(C)C)C1=O
|
C=CC(=O)NCOCC(C)C
|
C=CC(=O)N1CCOC2=CC=C2C=C(CC(C)C)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1=O",
"old_substring": "N1CO2"
}
|
Can you make molecule C=CC(=O)NCOCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)N1CCC(O)(CC(C)C)CC1
|
C=CC(=O)NCOCC(C)C
|
C=CC(=O)N1CCC(O)(CC(C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&(O)CC1",
"old_substring": "N1CO2"
}
|
Can you make molecule C=CC(=O)NCOCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)N1CCO[C@H](CC(C)C)C1
|
C=CC(=O)NCOCC(C)C
|
C=CC(=O)N1CCO[C@H](CC(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCO[C@H]&C1",
"old_substring": "N1CO2"
}
|
Can you make molecule C=CC(=O)NCOCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)N1CCO[C@@H](CC(C)C)C1
|
C=CC(=O)NCOCC(C)C
|
C=CC(=O)N1CCO[C@@H](CC(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCO[C@@H]&C1",
"old_substring": "N1CO2"
}
|
Can you make molecule Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CN2C[C@@]3(CCCN(SC(=O)Cc4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(SC(=O)Cc4cccc(O)c4)C3)CCC2=O)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C56=O"
}
|
Can you make molecule Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CCCC(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CCCC(=O)c4cccc(O)c4)C3)CCC2=O)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C56=O"
}
|
Can you make molecule Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CC(C)(C)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CC(C)(C)c4cccc(O)c4)C3)CCC2=O)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C56=O"
}
|
Can you make molecule Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CCC(C)(C)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)CCC(C)(C)c4cccc(O)c4)C3)CCC2=O)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C56=O"
}
|
Can you make molecule Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CN2C[C@@]3(CCCN(SC(=O)[C@@H](C)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(C(=O)c4cccc(O)c4)C3)CCC2=O)cn1
|
Cc1cnc(CN2C[C@@]3(CCCN(SC(=O)[C@@H](C)c4cccc(O)c4)C3)CCC2=O)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C56=O"
}
|
Can you make molecule O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C5C6"
}
|
Can you make molecule O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N=CCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(N=CCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C5C6"
}
|
Can you make molecule O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCCCCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCCCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5C6"
}
|
Can you make molecule O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CC(NS(=O)(=O)c2cccc(Cl)c2)C1)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
O=C(NC1CC(NS(=O)(=O)c2cccc(Cl)c2)C1)C12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C5C6"
}
|
Can you make molecule O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCNS(=O)(=O)c1cccc(Cl)c1)=NC(=O)C12CC3CC(CC(C3)C1)C2
|
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1)C12CC3CC(CC(C3)C1)C2
|
CC(CCNS(=O)(=O)c1cccc(Cl)c1)=NC(=O)C12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C5C6"
}
|
Can you make molecule CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc2c(cc1OCC)CN(C(=O)NCSC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NCSC[C@@H]1CCC[NH+]1CC)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N49"
}
|
Can you make molecule CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc2c(cc1OCC)CN(C(=O)N1CC(C[C@@H]3CCC[NH+]3CC)C1)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)N1CC(C[C@@H]3CCC[NH+]3CC)C1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&C1",
"old_substring": "N49"
}
|
Can you make molecule CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC(=N)SC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC(=N)SC[C@@H]1CCC[NH+]1CC)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N49"
}
|
Can you make molecule CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc2c(cc1OCC)CN(C(=O)N(C)C(=S)SC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)N(C)C(=S)SC[C@@H]1CCC[NH+]1CC)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N49"
}
|
Can you make molecule CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc2c(cc1OCC)CN(C(=O)N1CCN=C1SC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)NC[C@@H]1CCC[NH+]1CC)CC2
|
CCOc1cc2c(cc1OCC)CN(C(=O)N1CCN=C1SC[C@@H]1CCC[NH+]1CC)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N49"
}
|
Can you make molecule C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1[NH2+]CCC[C@@H]1NSC(=O)Cc1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NSC(=O)Cc1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CCCC(=O)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CCCC(=O)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CC(C)(C)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CC(C)(C)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CCC(C)(C)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)CCC(C)(C)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN[C@H]1CCC[NH2+][C@@H]1C)c1cccc(OC(F)F)c1
|
C[C@H]1[NH2+]CCC[C@@H]1NC(=O)c1cccc(OC(F)F)c1
|
C[C@H](C(=O)SN[C@H]1CCC[NH2+][C@@H]1C)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C25=O"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC3(C)CCCC3)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC3(C)CCCC3)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CCCC1",
"old_substring": "C4(C)C"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(Cl)(Cl)Cl)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(Cl)(Cl)Cl)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C4(C)C"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)Oc1ccc(S(=O)(=O)N2CCC[C@@H](C(=O)NC)C2)cc1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1
|
CCCC(C)(C)Oc1ccc(S(=O)(=O)N2CCC[C@@H](C(=O)NC)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C4(C)C"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(CC)Oc1ccc(S(=O)(=O)N2CCC[C@@H](C(=O)NC)C2)cc1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1
|
CCC(C)(CC)Oc1ccc(S(=O)(=O)N2CCC[C@@H](C(=O)NC)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "C4(C)C"
}
|
Can you make molecule CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC3(C=O)CCCCCC3)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1
|
CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC3(C=O)CCCCCC3)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C=O)CCCCCC1",
"old_substring": "C4(C)C"
}
|
Can you make molecule CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCN(C(=O)CC(C)(C)n2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CC(C)(C)n2c(=O)c3cccn3c3cccnc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)CC6"
}
|
Can you make molecule CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCN(C(=O)CCC(C)(C)n2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCC(C)(C)n2c(=O)c3cccn3c3cccnc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)CC6"
}
|
Can you make molecule CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCN(C(=O)C[C@H](C)n2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)C[C@H](C)n2c(=O)c3cccn3c3cccnc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "C4(=O)CC6"
}
|
Can you make molecule CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCN(C(=O)C[C@@H](Br)n2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)C[C@@H](Br)n2c(=O)c3cccn3c3cccnc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C4(=O)CC6"
}
|
Can you make molecule CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCN(SC(=O)[C@@H](C)n2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(C(=O)CCn2c(=O)c3cccn3c3cccnc32)CC1
|
CCCN1CCN(SC(=O)[C@@H](C)n2c(=O)c3cccn3c3cccnc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C4(=O)CC6"
}
|
Can you make molecule COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2cn(SCC(=O)N3CCOCC3)nc2-c2ccoc2C)cc1
|
COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1
|
COc1ccc(-c2cn(SCC(=O)N3CCOCC3)nc2-c2ccoc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cn&nc1&",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-c2cc(SCC(=O)N3CCOCC3)nc3c(-c4ccoc4C)ncn23)cc1
|
COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1
|
COc1ccc(-c2cc(SCC(=O)N3CCOCC3)nc3c(-c4ccoc4C)ncn23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2c&ncn12",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2cc(SCC(=O)N3CCOCC3)c3c(-c4ccoc4C)ncnc32)cc1
|
COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1
|
COc1ccc(-n2cc(SCC(=O)N3CCOCC3)c3c(-c4ccoc4C)ncnc32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&c2c&ncnc21",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2ccc3nc(SCC(=O)N4CCOCC4)nc(-c4ccoc4C)c32)cc1
|
COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1
|
COc1ccc(-n2ccc3nc(SCC(=O)N4CCOCC4)nc(-c4ccoc4C)c32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc2nc&nc&c21",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2cnc3c(SCC(=O)N4CCOCC4)cn(-c4ccoc4C)c3c2=O)cc1
|
COc1ccc(-n2c(SCC(=O)N3CCOCC3)nnc2-c2ccoc2C)cc1
|
COc1ccc(-n2cnc3c(SCC(=O)N4CCOCC4)cn(-c4ccoc4C)c3c2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cnc2c&cn&c2c1=O",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCS2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CC1)OCCS2",
"old_substring": "N13CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCCO2)CC1
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCCO2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CCCO2)CC1",
"old_substring": "N13CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCC2)C1
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CCC2)C1",
"old_substring": "N13CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCOCC2)C1
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCOCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CCOCC2)C1",
"old_substring": "N13CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCCC2)C1
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CC1)OCCO2
|
Cc1cc(N2CCCCS2(=O)=O)cc(C)c1S(=O)(=O)N1CCC2(CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CCCC2)C1",
"old_substring": "N13CCC2(CC1)OCCO2"
}
|
Can you make molecule COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)cc1I
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1
|
COc1ccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)ccc1Br
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1
|
COc1cc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)cc1Cl
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1
|
COc1ccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1Br
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1Cl
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1
|
COc1cccc(CN(C)C(=O)C(=O)Nc2cccc3cccnc23)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16cccc9c1"
}
|
Can you make molecule COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(C)C(=O)[C@H]1CN([C@H](C)c2cccc([N+](=O)[O-])c2)C[C@@H]1C
|
COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CN([C@H](C)c2cccc([N+](=O)[O-])c2)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CN&C[C@@H]1C",
"old_substring": "[C@H]17CCC[NH+]6C1"
}
|
Can you make molecule COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(C)C(=O)[C@H]1C=C[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1C=C[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[C@H]17CCC[NH+]6C1"
}
|
Can you make molecule COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(C)C(=O)[C@H]1CCC[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CCC[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]17CCC[NH+]6C1"
}
|
Can you make molecule COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(C)C(=O)[C@H]1C=C[C@@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1C=C[C@@H]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[C@H]17CCC[NH+]6C1"
}
|
Can you make molecule COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(C)C(=O)[C@H]1CCC[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)CC1
|
COCCN(C)C(=O)[C@H]1CCC[NH+]([C@H](C)c2cccc([N+](=O)[O-])c2)C1
|
COCCN(C)C(=O)[C@H]1CCC[C@H]([C@H](C)c2cccc([N+](=O)[O-])c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@H]17CCC[NH+]6C1"
}
|
Can you make molecule O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(c1ccc2c(c1)CCCC2)c1sc2cc(F)ccc2c1Cl
|
O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2
|
O=S(=O)(c1ccc2c(c1)CCCC2)c1sc2cc(F)ccc2c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2cc(F)ccc2c1Cl",
"old_substring": "N3[C@H]1CCSc2c(F)cccc21"
}
|
Can you make molecule O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2sc(S(=O)(=O)c3ccc4c(c3)CCCC4)c(C)c2c1
|
O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2
|
Cc1ccc2sc(S(=O)(=O)c3ccc4c(c3)CCCC4)c(C)c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&c(C)c2c1",
"old_substring": "N3[C@H]1CCSc2c(F)cccc21"
}
|
Can you make molecule O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(Br)ccc(S(=O)(=O)c2ccc3c(c2)CCCC3)c1C
|
O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2
|
Cc1c(Br)ccc(S(=O)(=O)c2ccc3c(c2)CCCC3)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c(Br)ccc&c1C",
"old_substring": "N3[C@H]1CCSc2c(F)cccc21"
}
|
Can you make molecule O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(c1ccc2c(c1)CCCC2)c1cc2sc(Cl)cc2s1
|
O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2
|
O=S(=O)(c1ccc2c(c1)CCCC2)c1cc2sc(Cl)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sc(Cl)cc2s1",
"old_substring": "N3[C@H]1CCSc2c(F)cccc21"
}
|
Can you make molecule O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2c(Cl)c(S(=O)(=O)c3ccc4c(c3)CCCC4)sc2c1
|
O=S(=O)(N[C@H]1CCSc2c(F)cccc21)c1ccc2c(c1)CCCC2
|
Cc1ccc2c(Cl)c(S(=O)(=O)c3ccc4c(c3)CCCC4)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2cc(C)ccc2c1Cl",
"old_substring": "N3[C@H]1CCSc2c(F)cccc21"
}
|
Can you make molecule Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@@H](CCC(F)(F)F)C(C)(C)C
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@@H](CCC(F)(F)F)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@H]16CCC[C@@H]7C1"
}
|
Can you make molecule Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@@H](C)CC(C)(C)CC(F)(F)F
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@@H](C)CC(C)(C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]16CCC[C@@H]7C1"
}
|
Can you make molecule Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCC(F)(F)F)NC(=O)Nc1ccc(N(C)C)cc1C
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CCCC[C@@H](CCC(F)(F)F)NC(=O)Nc1ccc(N(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "[C@H]16CCC[C@@H]7C1"
}
|
Can you make molecule Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N(C)C)ccc1NC(=O)N=CCC[C@@H](C)CC(F)(F)F
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
Cc1cc(N(C)C)ccc1NC(=O)N=CCC[C@@H](C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "[C@H]16CCC[C@@H]7C1"
}
|
Can you make molecule Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N(C)C)ccc1NC(=O)N=CCC[C@H](C)CC(F)(F)F
|
Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
Cc1cc(N(C)C)ccc1NC(=O)N=CCC[C@H](C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@H](C)C&",
"old_substring": "[C@H]16CCC[C@@H]7C1"
}
|
Can you make molecule CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
C=CSc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(C(C)C)cccc12
|
CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(C(C)C)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
C=CCCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(CCCCl)cccc12
|
CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(CCCCl)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(CCCCS)cccc12
|
CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
|
Cc1nnc(C)n1/N=C/c1c[nH]c2c(CCCCS)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
}
|
Can you make molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)CC(C)(C)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)CC(C)(C)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)CCC(C)(C)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)CCC(C)(C)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)C[C@@H](Br)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNC(=O)C[C@@H](Br)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1cc(C)n(N2CC[C@@H]([NH2+][C@H](C)CC(=O)Nc3cccc(F)c3)C2)c(=O)c1
|
CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNc1cc(C)n(N2CC[C@@H]([NH2+][C@H](C)CC(=O)Nc3cccc(F)c3)C2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1c(C)n(N2CC[C@@H]([NH2+][C@H](C)CC(=O)Nc3cccc(F)c3)C2)ccc1=O
|
CCNC(=O)N1CC[C@@H]([NH2+][C@H](C)CC(=O)Nc2cccc(F)c2)C1
|
CCNc1c(C)n(N2CC[C@@H]([NH2+][C@H](C)CC(=O)Nc3cccc(F)c3)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCC(C)C)s1
|
CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCC(C)C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCCCBr)s1
|
CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCCCBr)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
C=CCCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCCCCl)s1
|
CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
CCc1ccc([C@@H]2CC(=O)NC(=O)[C@@H]2CCCCCl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
|
C=CCCCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NSC2=NC(=O)C=[SH]2)c1
|
COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NSC2=NC(=O)C=[SH]2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C1=NC(=O)C=&S1",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(Nn2nc(C)c(C)cc2=O)c1
|
COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(Nn2nc(C)c(C)cc2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nn&c(=O)c&c1C",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NC(=O)n2cc(C#N)cn2)c1
|
COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NC(=O)n2cc(C#N)cn2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cn(C&=O)nc1&",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NCC2=NN=C(C=O)C2)c1
|
COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NCC2=NN=C(C=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=NN=C(C&=O)C1",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NCCC=CO)c1
|
COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1
|
CC(=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.COc1cccc(NCCC=CO)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C4%10=O"
}
|
Can you make molecule C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)N1Cc2nc(C[C@@H]3CCCO3)sc2C1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)N1Cc2nc(C[C@@H]3CCCO3)sc2C1)c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)N1Cc2cnn(C[C@@H]3CCCO3)c2C1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)N1Cc2cnn(C[C@@H]3CCCO3)c2C1)c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2cnn&c2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)N1CCc2noc(C[C@@H]3CCCO3)c2C1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)N1CCc2noc(C[C@@H]3CCCO3)c2C1)c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2noc&c2C1",
"old_substring": "N23"
}
|
Can you make molecule C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)N1CCCn2nc(C[C@@H]3CCCO3)cc21)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)N1CCCn2nc(C[C@@H]3CCCO3)cc21)c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCn2nc&cc21",
"old_substring": "N23"
}
|
Can you make molecule C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C(=O)N1CCc2cc(C[C@@H]3CCCO3)ccc21)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
|
C[C@@H](C(=O)N1CCc2cc(C[C@@H]3CCCO3)ccc21)c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "N23"
}
|
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