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3,859 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Have a physician confirmed diagnosis of knee osteoarthritis OR are both 1) over 50,
and 2) have experienced 4 weeks of pain, aching, or discomfort in or around the knee
during the last year (equal to or more than 28 separate or consecutive days).
- ... | SuPRA: Using Wearable Activity Trackers With a New Application to Improve Physical Activity in Knee Osteoarthritis | NCT02585323 | Entailment |
6,277 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- major
- having given his or her written consent and being able to consent
- For the prospective COVID-19 (+) sub-population : Diagnosis of COVID-19 by RT-PCR
SARS-CoV-2 (+)
- For the retrospectiveCOVID-19 (+) sub-population : Serum store... | Serology COVID-19 From the Cornwall Hospital Union | NCT04363593 | Entailment |
806 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male and female aged between 45 and 90 years
- Presence of activity-related joint pain
- Patients who have either no morning joint-related stiffness or morning stiffness that
lasts no longer than 30 minutes
- Patients who have not respon... | MRgFUS in the Treatment of Hand and Hip Osteoarthritic Pain | NCT03467165 | Entailment |
6,341 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients (18 -80 years) with mild to moderate COVID-19 cases consented to home or
hospital isolation to follow them.
Exclusion Criteria:
Severe cases not fulfilling the definition of mild and moderate cases.
Definition of mild cases according to The Egyp... | Nutritional Habits, and Coronavirus Disease 2019 (COVID-19) Outcome | NCT04447144 | Entailment |
4,844 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Shows lack of cortisol suppression
- Suppressed or low early-morning ACTH levels
- A radiologically confirmed adrenal lesion
- Has IGT or DM
- Has uncontrolled hypertension
Exclusion Criteria:
- Has severe, uncontroll... | Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas | NCT04308590 | Contradiction |
3,937 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Femorotibial knee OA (Uni- or bilateral)
- Responding to clinical and radiological criteria of American College of Rheumatology
(ACR)
- Symptomatic for more than 6 months in the most painful knee
- Radiological K&L grade II-III in radiog... | Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN | NCT02821468 | Entailment |
1,736 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Subjects must satisfy ALL of the following criteria to be eligible for enrollment into
the study:
1. Must understand and voluntarily sign a written Informed Consent (ICF) prior to any
study-related procedures being performed.
2. Must be able to c... | Study to Evaluate Bioavailability of Apremilast Oral Suspension Relative to Tablet and a Study to Assess Effect of Food on the Pharmacokinetic (PK) of the Oral Suspension | NCT02641353 | Entailment |
5,919 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Signed informed consent.
2. Head and neck cancer (HNC) Oropharynx cancer (OPC) patients who are adults > 18 years
of age, dispositioned to receive curative RT with bilateral neck (including) parotid
irradiation with or without chemotherapy.
... | Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy | NCT00928161 | Contradiction |
1,992 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age from over 18 to under 75 years
- Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy cStage
IA（T1N0M0）or cStage IB（T1N1M0，T2N0M0）at preoperative... | Clinical Efficacy Between Robotic and Laparoscopic Total Gastrectomy in Patients With Clinical Stage I Gastric Cancer | NCT03524300 | Entailment |
4,718 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Males and females 18-65 years of age, inclusive
2. BMI of 18-32.5 kg/m2, inclusive
3. Individuals with occupational (construction workers, manual labourers, athletes) and
non-occupational unresolved aches and discomfort for at least 2 weeks
... | A Study to Investigate the Efficacy of Pain Bloc-R in Healthy Participants With Non-pathological Aches and Discomfort | NCT03965819 | Entailment |
5,732 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Both gender;
- Fitzpatrick phototypes I - IV;
- age between 40 and 75 years;
- photodamaged skin with at least 1 lesion of actinic keratosis
Exclusion Criteria:
- Pregnancy and lactation;
- photosensitivity;
... | Transepidermal Application of Metilaminolevulinate in Daylight PDT in the Treatment of Photodamaged Skin | NCT03963765 | Contradiction |
2,600 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Age 18 or older
- Patients undergoing unilateral laparoscopic inguinal hernia repair, found to have a
contralateral occult inguinal hernia
Exclusion Criteria:
- Patient has life expectancy of less than 2 years
- Patients unlikel... | Treatment of Occult Inguinal Hernias | NCT04815707 | Contradiction |
5,845 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Males and non-pregnant females over the age of 18 years.
- Gastro-oesophageal symptoms in accordance with Montreal criteria49
- Patients who had oesophageal physiology testing at Guy's and St Thomas' NHS Foundation
Trust
- Oesophageal ma... | Physiological Predictors of Clinical Outcomes After Anti-reflux Surgery | NCT03390634 | Contradiction |
5,782 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- 20 pemphigus vulgaris patients
- healthy age and sex matched
Exclusion Criteria:
- - Patients with a history of topical or systemic treatment (corticosteroids,
intralesional steroid injection, immunosuppressive therapy, anticonvulsants and
... | Serum IL-21 Levels in Patients With Pemphigus Vulgaris | NCT03177213 | Contradiction |
1,893 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Key Inclusion Criteria:
1. Disease diagnosis and prior treatment:
1. Cohort 1 (the first-line breast cancer treatment cohort):
- Female participants with histologically or cytologically confirmed
unresectable, locally advanced, recurrent or metasta... | Anti-HER2 Bispecific Antibody ZW25 Activity in Combination With Chemotherapy With/Without Tislelizumab | NCT04276493 | Entailment |
2,105 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- In order to be eligible to participate in this study, the patient must meet all of the
following criteria:
Diagnosis of either definite or possible IPF according to the American Thoracic Society
(ATS) and European Respiratory Society (ERS) criteria Signed ... | Feasibility & Effect of a Tele-rehabilitation Program in Idiopathic Pulmonary Fibrosis (IPF) | NCT03548181 | Entailment |
1,413 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- diagnosed with essential hypertension
- systolic blood pressure >140 mm Hg (130 if diabetic) OR diastolic blood pressure > 90
mm Hg (80 if diabetic)on at least 2 clinic visits prior to randomization
- BP at time of screening is > than systolic 140 (... | A Study in the Use of Home Blood Pressure Monitoring and Telephone Follow-up to Control Blood Pressure | NCT00662753 | Contradiction |
5,246 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Clinical diagnosis of osteoporosis
- No other severe disabling conditions
- Should have at least 1 vertebral or non-vertebral prevalent fracture, and bone mineral
density T-score should be less than -2.5
- Ambulatory
- Men (a... | A Study for Patients With Osteoporosis | NCT00414973 | Entailment |
4,667 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- HV aged between 18 - 60 years
Exclusion Criteria:
- history of psychiatric disease or a positive first degree psychiatric family history
- pregnancy or lactation
- concomitant administration of any centrally activating medication (anti-depre... | Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers | NCT04355455 | Entailment |
5,878 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion criteria:
- Subject must have a Body Mass Index (BMI) from 19-30 kg/m2
- Subject does not present with abnormal clinical lab findings
- Subject is able to tolerate a nasogastric pH electrode.
Exclusion criteria:
- Subject is Helicobacter-positive on a C... | A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine. | NCT00405119 | Contradiction |
6,560 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Aged <12 years ;
- Male severe (central laboratory tested FVIII:C <1%) hemophilia A patients;
- Previously received FVIII treatment (prophylactic or bleeding treatment), have the
relevant records and are verified to have accumulated EDs ≥150 days（6≤... | Safety,Efficacy and Pharmacokinetics Evaluation of SCT800 in Previously Treated Paediatric Patients With Severe Haemophilia A. | NCT03947320 | Contradiction |
4,601 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- The study included 80 women with ASA I-II,
- Aged 18 to 45 years, who were accepted to participate in the study,
- were smoking,
- did not use oral contraceptives,
- had no menstrual irregularity (regular 28 ± 2 days menstrual cycle)
... | Menstrual Cycle Phases on Recovery and Cognitive Function | NCT03708692 | Entailment |
6,374 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- All emergency department patients with suspected or diagnosed COVID-19.
Exclusion Criteria:
- Negative screening for COVID-19
- recent negative COVID-19 test
- no indication for isolation in the Emergency Department
No condition on gender to be... | Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection | NCT04422691 | Entailment |
880 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | **Patients must be able to get care at Nellis Air Force Base (a military installation) in
order to participate in this study**
Inclusion Criteria:
- Male and Female Active Duty and DoD Beneficiaries aged 18 years or older
- Hand pain, aching, or stiffness
And at least 3... | Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis. | NCT04692597 | Entailment |
4,952 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | INCLUSION CRITERIA:
A total of 20 subjects will be enrolled in the study. 10 normal subjects will be enrolled
in the study. All will have an 8-12 Hz component of physiologic tremor as determined by
neurophysiologic studies. Patients will have a prominent 8-12 Hz spike on accelerometry
r... | Effect of Alcohol on Tremors | NCT00001925 | Entailment |
3,877 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients who have a diagnosis of knee Osteoarthritis according to the American Society
of Rheumatology (ACR) criteria,
- Between 45 to 75 years of age
- Can read and write in Turkish language
Exclusion Criteria:
- Active synovit... | Strengthening Exercises Versus Proprioception and Balance Exercises in the Treatment of Knee Osteoarthritis | NCT03893981 | Entailment |
4,023 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients:
1. A diagnosis of knee OA and suitable for the study as determined by a responsible
physician, based on a medical evaluation including medical history, physical
examination, laboratory tests and cardiac monitoring.
... | fMRI Evaluation of Pain Central Sensitization Phenomena in Subjects With Knee Osteoarthritis | NCT01700634 | Entailment |
5,492 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Diagnosis of PMR by standard criteria. The Bird criteria will be used. 3 or more
features are required to make the diagnosis.
- Bilateral shoulder pain/stiffness
- Duration of symptoms <2/52
- Initial ESR >40 mm/h
... | Timed Release Tablet Prednisone in Polymyalgia Rheumatica | NCT00836810 | Contradiction |
2,483 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Prior Visual Field
Exclusion Criteria:
- Scotopic pupil less than 3 mm
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| To Compare the Octopus 311 and the Humphrey Field Analyzer 700 Series | NCT00441194 | Entailment |
1,657 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria
1. Males and females (of childbearing and non-childbearing potential) , between 18 and 55
years of age, inclusive. Women of childbearing potential (WOCBP) must use highly
effective methods of birth control (see Inclusion #3).
2. Females of non-childbear... | A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533. | NCT04323306 | Entailment |
6,569 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Hemophilia A patients at least 12 years of age
- At least 150 treatment exposure-days to previous FVIII products
- FVIII≤2% at screening or diagnosis (FVIII≤1% for PK study)
- CD4 Lympocyte cell count>400/㎕
- Patients willing to cooperate... | Efficacy and Safety of Recombinant Factor VIII (GreenGene) in Patients With Hemophilia A | NCT01568580 | Contradiction |
1,894 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Signed informed-consent form.
2. Aged 18-80 years.
3. Had partial or total D2 gastrectomy and achieved R0 resection.
4. Histologically confirmed gastric or gastro-oesophageal junction
adenocarcinoma，mucinous adenocarcinoma ，signet-ring cell... | T- XELOX in HER2-positive Stage III Gastric Cancer After D2 Gastrectomy | NCT02250209 | Entailment |
458 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Major, under 45 years with intrauterine trophoblastic retention after incomplete
miscarriage in the first quarter (termination of pregnancy < 14 WA),
- With desire of pregnancy ;
- Intrauterine trophoblastic retention diagnosed by transvaginal pelvi... | Effectiveness of Hysteroscopy in the Treatment of Intrauterine Trophoblastic Retentions | NCT02201732 | Contradiction |
1,262 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- ≥18 years of age
- Supected intra-thoracic malignancies with pleural involvement and referred for a
diagnostic procedure by thoracoscopy, CT guided biopsy or endosonography
Exclusion Criteria:
- Inability and willingness to provide informed... | Confocal Laser Endomicroscopy in Pleural Malignancies | NCT03290183 | Entailment |
2,814 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Age greater than or equal to 18 years old.
- Diagnosis of either chronic pelvic pain, functional abdominal pain, axial low back
pain, or migraine with or without aura of at least 3 months duration.
- English speaking
- Ability and willin... | Vibratory Stimulation for the Treatment of Chronic Pain | NCT04069572 | Contradiction |
4,903 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- self defined Caucasian
- clinically healthy
- BMI of ≤ 30,
- a systolic arterial blood pressure ≤190 mmHg,
- no rash or dermatologic condition or tattoos which may interfere with the placement
site
- no neurovascu... | Neurologic Examination of Wide and Narrow Tourniquets | NCT02023476 | Contradiction |
4,480 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- aged 18-30
- healthy civilians volunteers
- with no background illnesses
- with history of combat unit service in the IDF.
- fit to perform 10 Km moderate march while carrying load.
Exclusion Criteria:
- The existence... | Evaluation of Physical and Cognitive Performance After Simulated Road March Combines Physical and Cognitive Load Using a Virtual Reality Environment | NCT02644213 | Contradiction |
2,371 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
Group A (ambulant patients)
- Documented diagnosis of DMD by mutation analysis in the dystrophin gene or by
substantially reduced levels of dystrophin protein (i.e. absent or <5% of normal) on
Western blot or immunostaining
- Stable treatmen... | Tamoxifen in Duchenne Muscular Dystrophy | NCT03354039 | Entailment |
5,806 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Clinical inclusion
- Adults ≥ 18 years old, both genres, who consent to participate of the study;
- Presence of symptomatic reticular lesion and/or white-gray papules. In
afro-descendent individuals, reticular lesions may be associate... | Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus | NCT03386643 | Entailment |
6,279 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients must satisfy all of the following criteria unless otherwise stated:
1. Willing and able to provide informed consent
2. Male or female patients > 18 years of age on the day of informed consent
3. Have received a confirmed diagnosi... | Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19 | NCT04676867 | Entailment |
314 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Aged of 18 to 45
- Having menstrual cycle duration of 24 to 38 days
- Undergoing no more than 3 previous IVF/ICSI - FET cycles
- Having indications for frozen-thawed embryo transfer
- Agreeing to have no more than 2 embryos transferred
... | Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation. | NCT04804020 | Contradiction |
3,245 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients with watery eyes who are listed for punctoplasty surgery
- Patients with dry eyes secondary to Sjögren's (i.e. presence of anti-Ro/SSA or La/SSB
autoantibodies, reduced Schirmer's test less than 5mm over 5 minutes without local
anaesthesia... | Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. | NCT02849093 | Entailment |
2,175 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Clinical diagnosis of gout
- Must be able to understand questionnaires
Exclusion Criteria:
- Diagnosis not validated by rheumatologist
- Not able to sign informed consent
No condition on gender to be admitted to the trial.
No healthy subject... | Italian Observational Study Assessing the Impact of Gout on Patients Disability and Quality of Life | NCT01549210 | Contradiction |
3,341 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- bilateral sensorineural hearing loss
- normal middle ear status
Exclusion Criteria:
- pregnant or lactating
- serious mental health illness or medical/psychiatric hospitalization
- treatment with cancer chemotherapeutic agents or... | The Effect of Low-Level Laser Stimulation on Hearing Thresholds | NCT01820416 | Contradiction |
5,444 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Age: between 18-45 years old
- Hemoglobin concentration: less than or equal to 11.5 g/dL, greater than or equal to
8.0 g/dL
- BMI: less than or equal to 35
- Menstrual cycle: previous menstrual cycle interval between 26 to 34 days with l... | Estradiol vs Lysteda in Treatment of Heavy Menstrual Bleeding | NCT01659008 | Entailment |
5,195 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women of age group 50-70 having T score less than -2.5 SD or lower at
lumbar spine or proximal femur.
Exclusion Criteria:
- Patients with renal dysfunction (serum creatinine >1.5)
- Primary and secondary hyperparathyroidism
... | Weekly vs Daily Teriparatide Therapy in Severe Postmenopausal Osteoporosis | NCT01760798 | Entailment |
5,842 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients with clinical symptoms of acid regurgitation, heart burn, or feeling of
acidity in the stomach, who have Los Angeles Grade A and B erosive esophagitis proven
by endoscopy were recruited
Exclusion Criteria:
- taking antisecretory a... | Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A and B | NCT03128736 | Contradiction |
1,510 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Patients aged 55+
- Patients showing impaired safety of the deglutition during the V-VST (volume -
viscosity swallow test): Cough oxygen desaturation ≥3% or voice change.
- Neurodegenerative or ischemic/hemorrhagic cerebral cause (stroke) or elderly... | Efficacy of Natural Ingredient to Improve the Swallowing Response of Patients With Oropharyngeal Dysphagia | NCT02422576 | Entailment |
5,528 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
Diagnosis of GCA classified according to the following criteria:
- Age at onset of disease ≥ 50 years.
- History of ESR ≥ 30 mm/hr or CRP ≥ 10 mg/L.
- Unequivocal cranial symptoms of GCA (new-onset localized headache, scalp or temporal
artery... | A Placebo-controlled Phase 2 Trial to Investigate the Safety and Efficacy of Secukinumab in Giant Cell Arteritis | NCT03765788 | Entailment |
4,567 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women 18-29 years old
- Unprotected vaginal or anal sex with at least one man that they perceive as engaging
in risky behavior OR
- Unprotected vaginal or anal sex with more than 1 man regardless of perceived partner
risk
- ... | Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones | NCT03330522 | Contradiction |
1,975 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- confirmed diagnosis of stomach cancer
- advanced stomach cancer of stage IV
- adequate blood chemistry, blood counts and kidney function
- willing to participate to study requirements and sign an informed consent document
Exclusion Criteria:... | Study Of Sunitinib In Combination With Cisplatin/Capecitabine Or Oxaliplatin/Capecitabine In Patients With Advanced Gastric Cancer | NCT00555620 | Entailment |
1,632 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Request for an initial appointment with a primary care physician at Beth Israel
Deaconess Medical Center who has agreed to participate in the study
- English as first language
- Internet access at home
Exclusion Criteria
- Under... | Patient Computer Dialog in Primary Care | NCT00386776 | Entailment |
2,951 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
Inclusion Criteria for subjects with early ALS:
- Probable or definite ALS according to World Federation of Neurology diagnostic
criteria4.
- Early stage ALS defined as presence of:
1. Normal lower extremities muscle strength (≥ 4/5 in ma... | Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS) | NCT00956501 | Entailment |
5,849 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Subjects must have had a pH probe test at Thomas Jefferson University between July
2004 and January 2006 with findings consistent with GERD.
- Male or female over the age of 18
Exclusion Criteria:
- Hypersensitivity to zolpidem or any of it... | The Influence of Hypnotic Medications on Sleep Arousal and Its Effect on Gastroesophageal Reflux | NCT00462137 | Contradiction |
1,946 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age 18 years-old or above
- Suffering from solid neoplasms of the stomach, liver, kidney or adrenals (<5cm in
largest diameter) that is indicated for treatment.
- Unsuitable for surgery, due to one (or more) of the following items:
-... | EUS-guided RFA for Solid Abdominal Neoplasms | NCT03221335 | Entailment |
6,388 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Adult patients (>18 years)
- Confirmed COVID-19 infection by real-time PCR from a respiratory or other body sample
within 48 hours of testing.
- Mild to moderate infection or asymptomatic patients with comorbidities: Symptomatic
patient... | Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death | NCT04323631 | Entailment |
1,877 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients must have histologically or cytologically confirmed adenocarcinoma of the GE
junction or stomach, which is beyond the scope of surgical resection
- Patients must have measurable disease, defined as at least one lesion that can be
accuratel... | Bortezomib With or Without Irinotecan in Treating Patients With Cancer of the Gastroesophageal Junction or Stomach | NCT00061932 | Entailment |
5,553 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Birth length below -2 SD
- Height at start below - 2 Sd
Exclusion Criteria:
- Any endocrine or chronic disease
- Any known syndrome with short stature
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join t... | Treatment Of Children With Short Stature At An Age Of 3-7 Years Who Were Born Small For Gestational Age | NCT00174408 | Contradiction |
3,129 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients diagnosed as Secondary Sjogren syndrome according to the 2002 American
European consensus group (AECG) criteria, which require the presence of well defined
major connective tissue disease (such as rheumatoid arthritis and systemic lupus
e... | Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome | NCT03865888 | Contradiction |
4,990 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Essential Tremor
- Subjects must be 50 years of age or older.
- Subjects must have been diagnosed with Essential Tremor
- Subjects must live within 3 hours of UTSW
- Parkinson's Disease
- Subjects must be 5... | Environmental Epidemiology of Essential Tremor | NCT04576676 | Entailment |
1,721 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criterion:
- Age ≥ 18 and ≤ 60 years.
- Control subjects without any history of wrist injury or disease.
Exclusion Criteria (applied to both wrists for control subjects):
- Previously-diagnosed rheumatological conditions or connective tissue diseases;
- ... | A Study to Evaluate 4DCT Controls | NCT04736537 | Entailment |
5,542 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Age > 50 years
- GCA fulfilling ≥3/5 ACR criteria
- Newly diagnosed GCA or relapsing GCA if treatments
(Glucocorticoids±immunosuppressants) have been stopped for at least 6 months
- Glucocorticoids started for less than 21 days
... | Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Giant Cell Arteritis: Proof of Concept Study. | NCT01910038 | Entailment |
4,431 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- HMRS of the elbow, distal humerus or total humerus
Exclusion Criteria:
- Unwillingness to participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Management of Bone Defects Around the Elbow | NCT00873145 | Contradiction |
991 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Included in this study were male and female subjects
- Age between 18 and 90 years
- With complaint of skeletal muscle pain
- Do not present cognitive deficit that makes the study impossible
Exclusion Criteria:
- Individuals who ... | Application and Comparison of Fuzzy Scale for the Evaluation of Pain Skeletal Muscle With the Numerical Pain Scale | NCT03710954 | Entailment |
4,600 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Women within ages of 18 to 45 years old with good health and regular menstrual cycles
with last menstrual cycle occurred within 5 weeks of enrolment; subjects can be
rescreened after completion of menstrual cycle
2. Women who use sanitary pads as th... | Proof Of Concept Menstrual Hygiene Product-Wondaleaf® | NCT02857972 | Entailment |
232 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 18 to 40 years of age
- BMI of 18 to 30 kg/m2
- regular menstrual cycles from 25 to 32 days
- established diagnosis of infertility.
Exclusion Criteria:
- Less then 18 or more then 40 years old
- BMI less then 18 or mo... | Oocyte Retrieval Progesterone Levels and IVF | NCT04447677 | Contradiction |
315 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Single intrauterine pregnancy
- Gestational age less than 10 weeks
Exclusion Criteria:
- Any condition distorting uterine cavity as myoma, uterine anomalies.
- Absent fetal pulsations
- Any condition needing termination of early ... | Relation of Implantation Site to Placental Site | NCT02765984 | Contradiction |
4,959 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Male or female
- 18 years of age or older
- Any ethnic background
- History of a primary diagnosis of essential tremor or Parkinson's disease
- Present for the MRgFUS tremor treatment
- Ability to understand and agree to infor... | Mapping the Target for the MRgFUS Treatment of Tremor | NCT04661241 | Entailment |
5,857 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Aged greater than or equal to 18 years and less than or equal to 70 years.
2. BMI >27.5 (based on kg/m2)
4. Not taking acid suppressant PPI and H2 receptor blockers 5. Not taking antacids or
alginate preparations, except those administered as part of study p... | Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants | NCT03516188 | Contradiction |
2,865 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Familial or sporadic ALS diagnosed as probable, laboratory-supported probable or
definite according to the World Federation of Neurology El Escorial criteria,
- Age 18 or older,
- Capable of providing informed consent and complying with trial proced... | Safety of Caprylic Triglycerides in ALS: A Pilot Study | NCT02716662 | Entailment |
4,564 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- BMI 28-35
Exclusion Criteria:
- Severe disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years | Dietary Advice on Prescription in Kungsbacka | NCT01385930 | Contradiction |
2,989 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Diagnosis of Fragile X syndrome by genetic testing of molecular biology, full mutation
result methylation.
2. Having an older age of 1 year and less than 9 years
3. Having signed the informed consent document before starting their participation in the... | Clinical Trial for Asses the Safety and Efficacy of Vitamin C and Vitamin E in Combination Versus Placebo for Treating Cognitive and Behavior Disorder in Children With Fragile X Syndrome | NCT02942498 | Contradiction |
5,409 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Male or female 7 years of age or older
2. The subject has been diagnosed of inherited VWD of Type 3 as determined by subject's
medical records.
3. The subject needs a surgical procedure (at least 10 surgical procedures have to be
consider... | Efficacy of Alphanate FVIII/VWF Concentrate in Type 3 Von Willebrand Patients | NCT00555555 | Entailment |
2,205 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Meets the diagnosis of gout according to the American Rheumatism Association (ARA)
Criteria for the Classification of Acute Arthritis of Primary Gout.
- Not on a urate lowering therapy (ULT) must have an sUA level ≥ 8.0 mg/dL at screening.
- If on c... | Allopurinol Outcome Study | NCT01391325 | Contradiction |
6,338 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age 18 years or older.
- Test result indicating presence of SARS-CoV-2 virus. Sites must have results from
assays that are approved as FDA-emergency use authorized or as standard-of-care by
other applicable regional governing bodies. For timing of ... | A Study of Immune Responses to the Virus That Causes COVID-19 | NCT04431414 | Entailment |
4,804 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Five years of age or older at the time of implantation
- Unilateral profound hearing loss, as defined by a pure-tone average (500, 1000, 2000,
and 4000 Hz) of 90 dB or greater in the ear to be implanted
- Sensorineural hearing loss in the ear to be ... | Single-Sided Deafness and Asymmetric Hearing Loss | NCT04506853 | Entailment |
5,515 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. Patients with newly onset Giant Cell Arteritis (GCA) with diagnosis of GCA within 4
weeks before screening visit, satisfying ACR criteria and a CRP > 25 mg/L AND biopsy
proven GCA (according to ACR criteria) OR a large vessel vasculitis assessed by MR
... | Giant Cell Arteritis Treatment With Ultra-short Glucocorticoids and Tocilizumab | NCT03745586 | Entailment |
6,681 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Adult
- Hemophilia A or B
- Pregnancy between 2014 and 2016
Exclusion Criteria:
- Opposition
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Health Practice of Hemophilia Patiente Care During Pregnancy, Delivery and Newborn Children | NCT03360149 | Contradiction |
3,475 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Type 2 diabetes mellitus with stable antidiabetic treatment since at least three
months
- Total cholesterol concentrations >135mg/dl and/or concomitant lipid lowering therapy
with HMGCoA inhibitors
- Serum creatinine ≤1.5mg/dl
... | Ezetimibe and Simvastatin in Dyslipidemia of Diabetes | NCT00157482 | Entailment |
3,179 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
To be eligible for inclusion, each Participant must meet each of the following:
1. Male or female aged ≥ 18 years and ≤ 79 years at date of consent
2. Primary Sjögren's Syndrome diagnosed by a rheumatologist
3. Patient has symptoms of dry eye, and has failed... | LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients | NCT03140111 | Entailment |
4,331 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Vital Signs, EKG and Clinical Laboratory Values within the normal range
- Body mass index (BMI) [20-29kg/m2]
- Caucasian male
- Age between [18-55]
- Healthy by physical exam
- Non or ex-smoker
Exclusion Criteria:
... | Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin | NCT01146483 | Contradiction |
895 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Diagnosis of KOA;
2. Age 40-75 years;
3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 3 months;
4. NRS score of pain at least more than 4 points;
5. Single/bilateral knee pain, duration of more than 6 month; If the patient has KOA on
... | Chinese Tuina Therapy for Treatment of Knee Osteoarthritis | NCT03966248 | Entailment |
3,708 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male and female individuals aged between 40 and 70 meeting the American College of
Rheumatology (ACR) criteria for primary knee OA with radiographic and symptomatic
evidence of TF OA for ≥6 months.
- Radiographic osteoarthritis Kellgren-Lawrence Gr... | Pilot Study of Therapy With Hylan G-F 20 Exercise Capacity | NCT01810848 | Contradiction |
334 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Women aged between 20 to 35 years old and with a history of infertility (fail to get
pregnant after over one year's regular, unprotected sex), who receive IVF/ICSI for one
of the following reasons:
① Tubal factor: e.g. peritubal adhesions, tubal ... | The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation | NCT03809221 | Contradiction |
3,545 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | PROTOCOL ENTRY CRITERIA:
--Disease Characteristics-- Primary adrenal insufficiency (Addison's disease) Serum
dehydroepiandrosterone less than 0.5 nmol/L --Prior/Concurrent Therapy-- No concurrent
investigational drug Stable glucocorticoid/mineralocorticoid dose over past year required
-... | Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency | NCT00004313 | Entailment |
5,435 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
Patients who meet all of the following criteria are eligible for the study:
- Aged ≥6 years at the time of screening
- VWD type 1 (baseline von Willebrand factor activity [VWF:Ristocetin Co-factor (RCo)]
<30 IU/dL, 2A, 2B, 2M, or 3 according to medical h... | Clinical Study to Investigate the Efficacy and Safety of Wilate During Prophylaxis in Previously Treated Patients With VWD | NCT04052698 | Entailment |
3,784 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male or female outpatient aged at least 18 years
- Patient suffering from predominant femoro-tibial knee osteoarthrosis with or without
effusion. The diagnosis must be based on American College of Rheumatology (ACR)
criteria. Radiological grade wil... | Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis | NCT02197026 | Entailment |
5,636 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Girls aged ≥9 years old
- Prepubertal - Tanner stage 1. (gonadarche) Breast at Tanner stage 1)
- Height and weight ≤ 10th percentile for age and gender.
- Height-SDS ≥ -2.5 SDS
- BMI-SDS>-2 SDS
- Low proportion between weight ... | Evaluating the Effect of Nutritional Supplementation on Growth of Short and Lean Adolescents Girls | NCT02397200 | Contradiction |
2,066 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Inclusion Criteria for Probable Idiopathic Pulmonary Fibrosis (IPF)
- Adult male or female patients aged 40 to 85 years
- Women of childbearing age should not be pregnant, planning to get pregnant or
breast-feeding.
- Command of the Engl... | Development of Airway Absorption Sampling Methods | NCT04494334 | Entailment |
2,980 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Intelligence tests results of less than 40 (patients <3 years old using the Gesell
Developmental Scale for screening; patients of 3-6 years old using Little Wechsler
Intelligence Scale for screening; patients >6 years old using Old Wechsler
Intell... | Whole Genome Sequencing in the Detection of Rare Undiagnosed Genetic Diseases in Children in China | NCT03424772 | Contradiction |
6,163 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age ≥ 18
- COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed).
- Tympanic Temperature of ≥37.5 AND at least one of the following: Cough, Sputum
production, nasal discharge, myalgia, headache or fatigue) on admission.
- Time of... | Azithromycin in Hospitalized COVID-19 Patients | NCT04359316 | Contradiction |
1,110 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Adult patients ≥18 years of age who underwent thoracotomy for septal myectomy.
Exclusion Criteria:
- Patients with severe liver and renal disease, severe central nervous system disease,
malignancy, defibrillators and age under 18 years old
No condition... | Risk Factors of Postoperative Complications in HCM Patients | NCT04275544 | Entailment |
3,649 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- the patients were registered in the ED from Jan, 2015 to Dec, 2015.
Exclusion Criteria:
- the patients were excluded because of left without seeing a physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Reducing Length of Stay in the Emergency Department | NCT03185533 | Entailment |
846 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Osteoarthritis of the knee according to American College of Rheumatology criteria:
Knee pain with 3 of the following:
- age >50 years
- stiffness less than 30 min
- crepitus,
- bony tenderness,
... | Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee | NCT03152578 | Entailment |
4,991 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Aged 18 years or older
- Clinical diagnosis of idiopathic Parkinson's disease or essential tremor
- Able to provide informed consent
Exclusion Criteria:
- Significant medical or psychiatric illness
- Not capable of following the ... | Movement Disorder Quantification Algorithm Development | NCT01534650 | Entailment |
629 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Symptomatic NYHA Class II-III heart failure >3 months
- Guideline-recommended heart failure treatment for > 3 months
- Hemoglobin >13 g/dl for men and >12 g/dl for women
- Functional iron deficiency (defined as serum ferritin level <100 ng/ml or betw... | Ferric Carboxymaltose to Improve Skeletal Muscle Metabolism in Heart Failure Patients With Functional Iron Deficiency | NCT03218384 | Contradiction |
647 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Willing and able to give informed consent for participation in the study
- Men and women aged 18 years or older and generally in good health
- Detectable tricuspid regurgitation on echocardiography during both normoxia and
hypoxia enabling measureme... | Iron Status and Hypoxic Pulmonary Vascular Responses | NCT01847352 | Contradiction |
2,805 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- At least 18 years of age
- Sporadic ALS diagnosed as definite, probable, or laboratory-supported probable as
defined by the revised El Escorial criteria
- Slow vital capacity (SVC) ≥60% of the predicted value at screening
- Onset of ALS ... | MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) | NCT04579666 | Contradiction |
4,210 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Age 18-50 of both genders
2. Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
3. History of episodic wheezing, chest tightness, or shortness of breath consistent with
asthma, or physician diagnosed asthma.
... | Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS | NCT02104505 | Contradiction |
3,033 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Have completed all scheduled visits in protocol 22001 and have shown they can
adequately follow the protocol, with sufficient medical justification to continue on
open-label treatment with STX209, as assessed by the principal investigator
Exclusion Cr... | An Open Label Extension Study of STX209 in Subjects With Fragile X Syndrome | NCT01013480 | Entailment |
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