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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of GLT8D2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
GLT8D2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GLT8D2 (glycosyltransferase 8 domain containing 2)
Type: protein-coding
Summary: Predicted to enable glycosyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: UDP-glycosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, membrane
Pathways:
UniProt: Q9H1C3
Entrez ID: 83468
|
Does Knockout of SRSF6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
SRSF6
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SRSF6 (serine and arginine rich splicing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splice site recognition, negative regulation of gene expression, negative regulation of keratinocyte differentiation, negative regulation of mRNA splicing, via spliceosome, negative regulation of type B pancreatic cell apoptotic process, positive regulation of epithelial cell proliferation involved in lung morphogenesis, regulation of alternative mRNA splicing, via spliceosome, regulation of keratinocyte proliferation, regulation of wound healing, response to insulin; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q13247
Entrez ID: 6431
|
Does Knockout of BCCIP in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
BCCIP
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: BCCIP (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, establishment of mitotic spindle orientation, microtubule anchoring, microtubule cytoskeleton organization, mitotic spindle assembly, mitotic spindle organization, neuroendocrine cell differentiation, regulation of cyclin-dependent protein serine/threonine kinase activity; MF: RNA binding, kinase regulator activity, protein binding, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle pole, nuclear cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9P287
Entrez ID: 56647
|
Does Knockout of TUBGCP2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
TUBGCP2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TUBGCP2 (tubulin gamma complex component 2)
Type: protein-coding
Summary: Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain development, cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, neuron migration, protein-containing complex assembly, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding, protein binding; CC: centrosome, ciliary basal body, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, gamma-tubulin complex, membrane, microtubule, microtubule organizing center, nucleoplasm, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q9BSJ2
Entrez ID: 10844
|
Does Knockout of KCP in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
KCP
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KCP (kielin cysteine rich BMP regulator)
Type: protein-coding
Summary: Predicted to act upstream of or within hematopoietic progenitor cell differentiation and positive regulation of BMP signaling pathway. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region
Pathways:
UniProt: Q6ZWJ8
Entrez ID: 375616
|
Does Knockout of TOP3A in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
TOP3A
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: TOP3A (DNA topoisomerase III alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA recombination, DNA repair, DNA topological change, chromosome separation, double-strand break repair via homologous recombination, meiotic cell cycle, mitochondrial DNA metabolic process, resolution of DNA recombination intermediates; MF: DNA binding, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, isomerase activity, metal ion binding, protein binding, single-stranded DNA binding, zinc ion binding; CC: PML body, RecQ family helicase-topoisomerase III complex, chromosome, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: ATM pathway, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Meiosis, Meiotic recombination, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Strand-asynchronous mitochondrial DNA replication, Transcriptional Regulation by TP53
UniProt: Q13472
Entrez ID: 7156
|
Does Knockout of SMC4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
SMC4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, mitotic sister chromatid segregation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Ciliary landscape, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase
UniProt: Q9NTJ3
Entrez ID: 10051
|
Does Knockout of TBC1D3F in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
TBC1D3F
|
cell proliferation
|
Cancer Cell Line
|
Gene: TBC1D3F (TBC1 domain family member 3F)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, protein binding; CC: endosome, membrane, plasma membrane
Pathways:
UniProt: A6NER0
Entrez ID: 84218
|
Does Knockout of TWIST2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
TWIST2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TWIST2 (twist family bHLH transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: cell differentiation, developmental process, negative regulation of DNA-templated transcription, negative regulation of osteoblast differentiation, positive regulation of cell migration, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Gene expression (Transcription), Generic Transcription Pathway, Negative Regulation of CDH1 Gene Transcription, Proteoglycans in cancer - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Transcriptional regulation by RUNX2
UniProt: Q8WVJ9
Entrez ID: 117581
|
Does Knockout of CD58 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
CD58
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CD58 (CD58 molecule)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: cell-cell adhesion, cellular response to tumor necrosis factor, cellular response to type II interferon, heterotypic cell-cell adhesion, immune response, positive regulation of interleukin-8 production; MF: protein binding, signaling receptor binding; CC: cell surface, extracellular exosome, ficolin-1-rich granule membrane, membrane, plasma membrane, secretory granule membrane
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell surface interactions at the vascular wall, Epstein-Barr virus infection - Homo sapiens (human), Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P19256
Entrez ID: 965
|
Does Knockout of FBXO2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
FBXO2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FBXO2 (F-box protein 2)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERAD pathway, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, glycoprotein catabolic process, negative regulation of cell population proliferation, protein modification process, protein ubiquitination, proteolysis, regulation of protein catabolic process at postsynapse, modulating synaptic transmission, regulation of protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: amyloid-beta binding, carbohydrate binding, denatured protein binding, protein binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, dendritic spine, endoplasmic reticulum, extrinsic component of postsynaptic membrane, glutamatergic synapse, membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ubiquitin mediated proteolysis - Homo sapiens (human), er associated degradation (erad) pathway
UniProt: Q9UK22
Entrez ID: 26232
|
Does Knockout of PPARGC1B in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
PPARGC1B
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PPARGC1B (PPARG coactivator 1 beta)
Type: protein-coding
Summary: The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: energy homeostasis, estrogen receptor signaling pathway, positive regulation of cold-induced thermogenesis, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: AF-2 domain binding, RNA binding, nuclear estrogen receptor binding, nucleic acid binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: cytosol, mediator complex, nucleoplasm, nucleus
Pathways: AMP-activated protein kinase (AMPK) signaling, Adipogenesis, Developmental Biology, Differentiation of white and brown adipocyte, Energy Metabolism, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, FOXA2 pathway, Gene expression (Transcription), Generic Transcription Pathway, Insulin resistance - Homo sapiens (human), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, Mitochondrial Gene Expression, Mitochondrial biogenesis, Organelle biogenesis and maintenance, PPARA activates gene expression, Prostaglandin Synthesis and Regulation, RNA Polymerase II Transcription, Regulation of RUNX2 expression and activity, Regulation of lipid metabolism by PPARalpha, Sterol regulatory element-binding proteins (SREBP) signaling, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation by RUNX2, Transcriptional regulation of brown and beige adipocyte differentiation, Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
UniProt: Q86YN6
Entrez ID: 133522
|
Does Activation of PDE10A in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
PDE10A
|
protein/peptide accumulation
|
T cell
|
Gene: PDE10A (phosphodiesterase 10A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cAMP catabolic process, cGMP catabolic process, negative regulation of cAMP/PKA signal transduction, negative regulation of cGMP-mediated signaling, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cAMP/PKA signal transduction, signal transduction; MF: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, cGMP binding, catalytic activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, nucleotide binding, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol, glutamatergic synapse, synapse
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, G alpha (s) signalling events, GPCR downstream signalling, Gout or Kelley-Seegmiller Syndrome, Hemostasis, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Morphine addiction - Homo sapiens (human), Myoadenylate deaminase deficiency, Nitric oxide stimulates guanylate cyclase, Phosphodiesterases in neuronal function, Platelet homeostasis, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, cAMP signaling pathway - Homo sapiens (human), cGMP effects
UniProt: Q9Y233
Entrez ID: 10846
|
Does Knockout of FOXRED1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
FOXRED1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: FOXRED1 (FAD dependent oxidoreductase domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q96CU9
Entrez ID: 55572
|
Does Knockout of RFC5 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RFC5
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RFC5 (replication factor C subunit 5)
Type: protein-coding
Summary: This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P40937
Entrez ID: 5985
|
Does Knockout of KYAT3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
KYAT3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: KYAT3 (kynurenine aminotransferase 3)
Type: protein-coding
Summary: This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-kynurenine catabolic process, amino acid metabolic process, kynurenine metabolic process; MF: RNA binding, cysteine-S-conjugate beta-lyase activity, kynurenine-glyoxylate transaminase activity, kynurenine-oxoglutarate transaminase activity, lyase activity, protein homodimerization activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, mitochondrion
Pathways: Chemical carcinogenesis - Homo sapiens (human), Cysteine and methionine metabolism - Homo sapiens (human), L-kynurenine degradation, Metabolism, Metabolism of amino acids and derivatives, Selenocompound metabolism - Homo sapiens (human), Tryptophan catabolism, Tryptophan metabolism - Homo sapiens (human)
UniProt: Q6YP21
Entrez ID: 56267
|
Does Knockout of TUSC3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
TUSC3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TUSC3 (tumor suppressor candidate 3)
Type: protein-coding
Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017].
Gene Ontology: BP: cognition, magnesium ion transmembrane transport, magnesium ion transport, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, transmembrane transport; MF: magnesium ion transmembrane transporter activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, oligosaccharyltransferase complex, plasma membrane
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, Co-inhibition by PD-1, Disease, Epithelial to mesenchymal transition in colorectal cancer, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, Miscellaneous transport and binding events, N-Glycan biosynthesis - Homo sapiens (human), PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Transport of small molecules, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: Q13454
Entrez ID: 7991
|
Does Knockout of LRR1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
LRR1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: LRR1 (leucine rich repeat protein 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: intracellular signal transduction, protein ubiquitination; CC: cytosol, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q96L50
Entrez ID: 122769
|
Does Knockout of SMIM2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
SMIM2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SMIM2 (small integral membrane protein 2)
Type: ncRNA
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 79024
|
Does Knockout of SLC32A1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
SLC32A1
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: SLC32A1 (solute carrier family 32 member 1)
Type: protein-coding
Summary: The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amino acid transmembrane transport, beta-alanine transport, gamma-aminobutyric acid import, gamma-aminobutyric acid transport, glycine transport, hippocampus development, monoatomic ion transport, neurotransmitter loading into synaptic vesicle, neurotransmitter secretion, neurotransmitter transport, proton transmembrane transport; MF: amino acid transmembrane transporter activity, gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:proton antiporter activity, gamma-aminobutyric acid:proton symporter activity, glycine transmembrane transporter activity, glycine:proton antiporter activity; CC: GABA-ergic synapse, cell projection, cell surface, cell tip, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, cone cell pedicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, dendrite terminus, inhibitory synapse, membrane, neuron projection, neuron projection terminus, plasma membrane, presynapse, presynaptic active zone, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: GABA receptor Signaling, GABA synthesis, release, reuptake and degradation, GABAergic synapse - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuronal System, Neurotransmitter release cycle, Nicotine addiction - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q9H598
Entrez ID: 140679
|
Does Knockout of RP9 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
RP9
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: RP9 (RP9 pre-mRNA splicing factor)
Type: protein-coding
Summary: The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: RNA splicing, cognition; MF: RNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus, signal recognition particle receptor complex
Pathways: Spliceosome - Homo sapiens (human)
UniProt: Q8TA86
Entrez ID: 6100
|
Does Knockout of TMEM198 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TMEM198
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TMEM198 (transmembrane protein 198)
Type: protein-coding
Summary: Involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway; CC: cytoplasmic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q66K66
Entrez ID: 130612
|
Does Knockout of RPL7A in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
RPL7A
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: RPL7A (ribosomal protein L7a)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA, ribosome biogenesis, translation; MF: RNA binding, cadherin binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62424
Entrez ID: 6130
|
Does Knockout of OR6C65 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
OR6C65
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: OR6C65 (olfactory receptor family 6 subfamily C member 65)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: A6NJZ3
Entrez ID: 403282
|
Does Knockout of MYBL2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
MYBL2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MYBL2 (MYB proto-oncogene like 2)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitotic cell cycle, mitotic spindle assembly, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: Myb complex, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Homo sapiens (human), E2F transcription factor network, EGF-EGFR signaling pathway, G0 and Early G1, G2/M Transition, Gastric Cancer Network 1, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Polo-like kinase mediated events, RNA Polymerase II Transcription, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: P10244
Entrez ID: 4605
|
Does Knockout of OR52B4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
OR52B4
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: OR52B4 (olfactory receptor family 52 subfamily B member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cognition, detection of chemical stimulus involved in sensory perception of smell, nervous system process, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Olfactory transduction - Homo sapiens (human)
UniProt: Q8NGK2
Entrez ID: 143496
|
Does Knockout of ALG11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
ALG11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG11 causes CDG-1p, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q2TAA5
Entrez ID: 440138
|
Does Knockout of CCT2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CCT2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CCT2 (chaperonin containing TCP1 subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: binding of sperm to zona pellucida, chaperone-mediated protein complex assembly, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: azurophil granule lumen, cell body, chaperonin-containing T-complex, cytoplasm, cytosol, extracellular exosome, extracellular region, microtubule, zona pellucida receptor complex
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Organelle biogenesis and maintenance, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P78371
Entrez ID: 10576
|
Does Knockout of CEND1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
CEND1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CEND1 (cell cycle exit and neuronal differentiation 1)
Type: protein-coding
Summary: The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adult walking behavior, cell differentiation, cerebellar Purkinje cell differentiation, cerebellar granular layer maturation, cerebellum development, negative regulation of cerebellar granule cell precursor proliferation, neuron differentiation, radial glia guided migration of cerebellar granule cell; CC: membrane, mitochondrion, vesicle
Pathways:
UniProt: Q8N111
Entrez ID: 51286
|
Does Knockout of HTR5A in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
HTR5A
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: HTR5A (5-hydroxytryptamine receptor 5A)
Type: protein-coding
Summary: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, chemical synaptic transmission, hippocampus development, response to estradiol, signal transduction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gi/o-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin receptor activity; CC: dendrite, membrane, perikaryon, plasma membrane, postsynaptic specialization membrane
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Monoamine GPCRs, Neuroactive ligand-receptor interaction - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Serotonin receptors, Signal Transduction, Signaling by GPCR
UniProt: P47898
Entrez ID: 3361
|
Does Knockout of COL21A1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
COL21A1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: COL21A1 (collagen type XXI alpha 1 chain)
Type: protein-coding
Summary: This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: CC: collagen trimer, cytoplasm, cytosol, endoplasmic reticulum lumen, extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Homo sapiens (human), Type 2 papillary renal cell carcinoma
UniProt: Q96P44
Entrez ID: 81578
|
Does Knockout of RAB9B in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
RAB9B
|
response to virus
|
Hepatoma Cell Line
|
Gene: RAB9B (RAB9B, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: Rab protein signal transduction, protein transport, receptor-mediated endocytosis, retrograde transport, endosome to Golgi; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding; CC: cytoplasmic vesicle, cytosol, late endosome, lysosome, membrane, organelle membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, secretory granule membrane
Pathways: Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Measles - Homo sapiens (human), Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RHOBTB3 ATPase cycle, Rab regulation of trafficking, Retrograde transport at the Trans-Golgi-Network, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9NP90
Entrez ID: 51209
|
Does Knockout of PSMB9 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
PSMB9
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PSMB9 (proteasome 20S subunit beta 9)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: immune system process, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, extracellular exosome, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, spermatoproteasome complex
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), ER-Phagosome pathway, Immune System, Metabolism of proteins, Post-translational protein modification, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, Type II interferon signaling (IFNG), antigen processing and presentation
UniProt: P28065
Entrez ID: 5698
|
Does Knockout of MAST2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
MAST2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MAST2 (microtubule associated serine/threonine kinase 2)
Type: protein-coding
Summary: Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, intracellular signal transduction, protein phosphorylation, regulation of interleukin-12 production, spermatid differentiation; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, microtubule binding, nucleotide binding, phosphatase binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytoskeleton, membrane, microtubule cytoskeleton, plasma membrane
Pathways:
UniProt: Q6P0Q8
Entrez ID: 23139
|
Does Knockout of RIBC1 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
RIBC1
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: RIBC1 (RIB43A domain with coiled-coils 1)
Type: protein-coding
Summary: Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: flagellated sperm motility; CC: axonemal A tubule inner sheath, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: Q8N443
Entrez ID: 158787
|
Does Knockout of ATP2A3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
ATP2A3
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)
Type: protein-coding
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, calcium ion transport from cytosol to endoplasmic reticulum, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of cardiac conduction, transport across blood-brain barrier; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, calcium channel regulator activity, calcium ion transmembrane transporter activity, calcium-dependent ATPase activity, cysteine-type endopeptidase activator activity involved in apoptotic process, metal ion binding, nucleotide binding, protein binding, transmembrane transporter binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus, organelle membrane, platelet dense tubular network membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Diabetic cardiomyopathy - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Myometrial relaxation and contraction pathways, Pancreatic secretion - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), nfat and hypertrophy of the heart
UniProt: Q93084
Entrez ID: 489
|
Does Knockout of GTF2B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
GTF2B
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, positive regulation of core promoter binding, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Homo sapiens (human), Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: Q00403
Entrez ID: 2959
|
Does Activation of PPP4R3A in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
PPP4R3A
|
response to virus
|
Hepatoma Cell Line
|
Gene: PPP4R3A (protein phosphatase 4 regulatory subunit 3A)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, gluconeogenesis, positive regulation of gluconeogenesis, regulation of double-strand break repair; MF: protein phosphatase activator activity, protein phosphatase regulator activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, nuclear speck, nucleoplasm, nucleus, protein phosphatase 4 complex
Pathways: 16p11.2 proximal deletion syndrome, Glucagon signaling pathway - Homo sapiens (human), Integrated breast cancer pathway
UniProt: Q6IN85
Entrez ID: 55671
|
Does Knockout of PYURF in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
PYURF
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PYURF (PIGY upstream open reading frame)
Type: protein-coding
Summary: The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. [provided by RefSeq, Aug 2012].
Gene Ontology: CC: endoplasmic reticulum membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q96I23
Entrez ID: 100996939
|
Does Knockout of SERP1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
SERP1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: SERP1 (stress associated endoplasmic reticulum protein 1)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum unfolded protein response and protein glycosylation. Predicted to act upstream of or within several processes, including multicellular organism aging; positive regulation of organ growth; and positive regulation of peptide hormone secretion. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum unfolded protein response, glucose metabolic process, insulin secretion, muscle organ morphogenesis, plasma membrane organization, positive regulation of growth hormone secretion, positive regulation of insulin secretion, positive regulation of organ growth, positive regulation of translation, post-embryonic development, protein glycosylation, protein modification process, protein transport, response to unfolded protein, skeletal system development; CC: cytoplasmic microtubule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, ribosome
Pathways: Cellular responses to stimuli, Cellular responses to stress, IRE1alpha activates chaperones, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Protein localization, Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: Q9Y6X1
Entrez ID: 27230
|
Does Knockout of NAA15 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
NAA15
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: N-terminal protein amino acid acetylation, angiogenesis, cell differentiation, negative regulation of apoptotic process, positive regulation of DNA-templated transcription, protein stabilization; MF: RNA binding, acetyltransferase activator activity, acetyltransferase activity, protein binding, ribosome binding; CC: NatA complex, cytoplasm, cytosol, membrane, nuclear body, nucleus, transcription regulator complex
Pathways:
UniProt: Q9BXJ9
Entrez ID: 80155
|
Does Knockout of ANAPC2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
ANAPC2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ANAPC2 (anaphase promoting complex subunit 2)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of mitotic cell cycle, negative regulation of gene expression, nervous system development, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of synapse maturation, positive regulation of synaptic plasticity, proteasomal protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin protein ligase binding; CC: anaphase-promoting complex, cullin-RING ubiquitin ligase complex, cytosol, nucleoplasm
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UJX6
Entrez ID: 29882
|
Does Knockout of MANSC4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
MANSC4
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MANSC4 (MANSC domain containing 4)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, epithelium development, extracellular matrix organization; CC: membrane, plasma membrane
Pathways:
UniProt: A6NHS7
Entrez ID: 100287284
|
Does Knockout of LIMK1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
LIMK1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LIMK1 (LIM domain kinase 1)
Type: protein-coding
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, Rho protein signal transduction, actin cytoskeleton organization, axon extension, nervous system development, positive regulation of actin filament bundle assembly, positive regulation of axon extension, positive regulation of stress fiber assembly, protein phosphorylation, signal transduction, stress fiber assembly; MF: ATP binding, heat shock protein binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cell junction, cell projection, cytoplasm, cytoskeleton, cytosol, focal adhesion, glutamatergic synapse, lamellipodium, male germ cell nucleus, membrane, neuron projection, nuclear speck, nucleus, postsynapse
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), CDC42 signaling events, CXCR4-mediated signaling events, Caspase Cascade in Apoptosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, G13 Signaling Pathway, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Innate Immune System, Leptin, Nervous system development, RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate PAKs, Regulation of Actin Cytoskeleton, Regulation of Microtubule Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, RhoA signaling pathway, Sema3A PAK dependent Axon repulsion, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, VEGFA-VEGFR2 Signaling Pathway, Yersinia infection - Homo sapiens (human), ccr3 signaling in eosinophils, rac1 cell motility signaling pathway, rho cell motility signaling pathway, role of mal in rho-mediated activation of srf
UniProt: P53667
Entrez ID: 3984
|
Does Knockout of MIR4493 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MIR4493
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MIR4493 (microRNA 4493)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616319
|
Does Knockout of MED22 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
MED22
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MED22 (mediator complex subunit 22)
Type: protein-coding
Summary: This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity; CC: core mediator complex, cytoplasm, mediator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q15528
Entrez ID: 6837
|
Does Knockout of CPNE7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CPNE7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CPNE7 (copine 7)
Type: protein-coding
Summary: This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: cellular response to calcium ion, lipid metabolic process; MF: calcium-dependent phospholipid binding, metal ion binding, protein binding; CC: cytoplasm, extracellular exosome, membrane, nucleus, plasma membrane, synapse
Pathways:
UniProt: Q9UBL6
Entrez ID: 27132
|
Does Knockout of ERLIN1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ERLIN1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ERLIN1 (ER lipid raft associated 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: ERAD pathway, SREBP signaling pathway, cholesterol metabolic process, lipid metabolic process, negative regulation of cholesterol biosynthetic process, negative regulation of fatty acid biosynthetic process, regulation of cholesterol biosynthetic process, steroid metabolic process; MF: cholesterol binding, lipid binding, protein binding, ubiquitin protein ligase binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, membrane raft, protein-containing complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Disorders of transmembrane transporters, Immune System, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: O75477
Entrez ID: 10613
|
Does Knockout of CNOT10 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
CNOT10
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CNOT10 (CCR4-NOT transcription complex subunit 10)
Type: protein-coding
Summary: Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mRNA catabolic process, negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, regulation of translation, regulatory ncRNA-mediated gene silencing; CC: CCR4-NOT complex, cytoplasm, cytosol, membrane, nucleus
Pathways: Ciliary landscape, RNA degradation - Homo sapiens (human)
UniProt: Q9H9A5
Entrez ID: 25904
|
Does Knockout of DCTN2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
DCTN2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: DCTN2 (dynactin subunit 2)
Type: protein-coding
Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: melanosome transport, microtubule-based process, mitotic metaphase chromosome alignment, mitotic spindle organization, protein localization to centrosome; MF: identical protein binding, protein binding, protein kinase binding, spectrin binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, dynein complex, extracellular exosome, growth cone, kinetochore, membrane, microtubule, vesicle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: Q13561
Entrez ID: 10540
|
Does Knockout of SCN5A in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SCN5A
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SCN5A (sodium voltage-gated channel alpha subunit 5)
Type: protein-coding
Summary: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene have been associated with long QT syndrome type 3 (LQT3), atrial fibrillation, cardiomyopathy, and Brugada syndrome 1, all autosomal dominant cardiac diseases. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2022].
Gene Ontology: BP: AV node cell action potential, AV node cell to bundle of His cell communication, SA node cell action potential, atrial cardiac muscle cell action potential, brainstem development, bundle of His cell action potential, cardiac conduction system development, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cardiac ventricle development, cellular response to calcium ion, cerebellum development, membrane depolarization, membrane depolarization during AV node cell action potential, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during SA node cell action potential, membrane depolarization during action potential, membrane depolarization during atrial cardiac muscle cell action potential, membrane depolarization during bundle of His cell action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, odontogenesis of dentin-containing tooth, positive regulation of action potential, positive regulation of epithelial cell proliferation, positive regulation of sodium ion transport, regulation of atrial cardiac muscle cell membrane depolarization, regulation of atrial cardiac muscle cell membrane repolarization, regulation of cardiac muscle cell contraction, regulation of cardiac muscle contraction, regulation of heart rate, regulation of heart rate by cardiac conduction, regulation of sodium ion transmembrane transport, regulation of ventricular cardiac muscle cell membrane depolarization, regulation of ventricular cardiac muscle cell membrane repolarization, response to denervation involved in regulation of muscle adaptation, sodium ion transmembrane transport, sodium ion transport, telencephalon development, transmembrane transport, ventricular cardiac muscle cell action potential; MF: ankyrin binding, calmodulin binding, enzyme binding, fibroblast growth factor binding, monoatomic cation channel activity, monoatomic ion channel activity, nitric-oxide synthase binding, protein binding, protein domain specific binding, protein kinase binding, scaffold protein binding, sodium channel activity, transmembrane transporter binding, ubiquitin protein ligase binding, voltage-gated sodium channel activity, voltage-gated sodium channel activity involved in AV node cell action potential, voltage-gated sodium channel activity involved in Purkinje myocyte action potential, voltage-gated sodium channel activity involved in SA node cell action potential, voltage-gated sodium channel activity involved in bundle of His cell action potential, voltage-gated sodium channel activity involved in cardiac muscle cell action potential; CC: T-tubule, Z disc, anchoring junction, caveola, cell surface, cytoplasm, endoplasmic reticulum, intercalated disc, lateral plasma membrane, membrane, monoatomic ion channel complex, nucleolus, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, sarcolemma, voltage-gated sodium channel complex
Pathways: Acebutolol Action Pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Axon guidance, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Cardiac Progenitor Differentiation, Cardiac conduction, Carteolol Action Pathway, Carvedilol Action Pathway, Developmental Biology, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Fosphenytoin (Antiarrhythmic) Metabolism Pathway, Ibutilide Action Pathway, Interaction between L1 and Ankyrins, Isoprenaline Action Pathway, Isradipine Action Pathway, L1CAM interactions, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Nervous system development, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phase 0 - rapid depolarisation, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway
UniProt: Q14524
Entrez ID: 6331
|
Does Knockout of TADA3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
TADA3
|
cell proliferation
|
Cancer Cell Line
|
Gene: TADA3 (transcriptional adaptor 3)
Type: protein-coding
Summary: DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Gene Ontology: BP: chromatin organization, estrogen receptor signaling pathway, mitotic cell cycle, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of protein stability, regulation of transcription by RNA polymerase II; MF: nuclear receptor binding, protein binding, protein domain specific binding, transcription coactivator activity; CC: ATAC complex, SAGA complex, mitotic spindle, nucleoplasm, nucleus, transcription factor TFTC complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones, Human papillomavirus infection - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: O75528
Entrez ID: 10474
|
Does Knockout of PAXBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
PAXBP1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: PAXBP1 (PAX3 and PAX7 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Gene Ontology: BP: mRNA splicing, via spliceosome, muscle organ development, positive regulation of myoblast proliferation, positive regulation of transcription by RNA polymerase II, regulation of skeletal muscle satellite cell proliferation, transcription by RNA polymerase II; MF: DNA binding, histone methyltransferase binding; CC: cytosol, nucleus
Pathways:
UniProt: Q9Y5B6
Entrez ID: 94104
|
Does Knockout of CENPH in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
CENPH
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CENPH (centromere protein H)
Type: protein-coding
Summary: Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromosome segregation, kinetochore assembly, kinetochore organization, mitotic spindle organization; MF: kinetochore binding, protein binding; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9H3R5
Entrez ID: 64946
|
Does Knockout of PDCL in Glioma Cell Line causally result in protein/peptide accumulation?
| 1
| 589
|
Knockout
|
PDCL
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: PDCL (phosducin like)
Type: protein-coding
Summary: Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell projection organization, heterotrimeric G-protein complex assembly, positive regulation of smoothened signaling pathway, regulation of G protein-coupled receptor signaling pathway, signal transduction, visual perception; CC: cell projection, cilium, cytoplasm, cytosol
Pathways: Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: Q13371
Entrez ID: 5082
|
Does Knockout of PPP1R2 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
PPP1R2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)
Type: protein-coding
Summary: Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: generation of precursor metabolites and energy, glycogen metabolic process, intracellular signal transduction, regulation of signal transduction; MF: molecular function inhibitor activity, protein binding, protein phosphatase inhibitor activity, protein serine/threonine phosphatase inhibitor activity
Pathways:
UniProt: P41236
Entrez ID: 5504
|
Does Knockout of SAMD4B in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SAMD4B
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SAMD4B (sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, regulation of mRNA stability; MF: RNA binding, mRNA binding, protein binding, translation repressor activity; CC: P-body, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5PRF9
Entrez ID: 55095
|
Does Knockout of SLC6A1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
SLC6A1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SLC6A1 (solute carrier family 6 member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, associative learning, chemical synaptic transmission, chloride transmembrane transport, gamma-aminobutyric acid import, gamma-aminobutyric acid reuptake, inorganic anion import across plasma membrane, memory, neurotransmitter reuptake, neurotransmitter transport, sodium ion import across plasma membrane, sodium ion transmembrane transport, synapse organization, transport across blood-brain barrier; MF: amino acid:sodium symporter activity, gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, metal ion binding, protein binding, sodium:chloride symporter activity, symporter activity, transmembrane transporter activity; CC: GABA-ergic synapse, axon, cell projection, cell surface, membrane, neuronal cell body, plasma membrane, presynapse, synapse
Pathways: Fragile X Syndrome, GABA synthesis, release, reuptake and degradation, GABAergic synapse - Homo sapiens (human), Monoamine Transport, NRF2 pathway, Neuronal System, Neurotransmitter release cycle, Nuclear Receptors Meta-Pathway, Reuptake of GABA, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Homo sapiens (human), Transmission across Chemical Synapses, Transport of small molecules
UniProt: P30531
Entrez ID: 6529
|
Does Knockout of SCYL3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SCYL3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SCYL3 (SCY1 like pseudokinase 3)
Type: protein-coding
Summary: This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: cell migration, inflammatory response, intracellular protein localization, neuron development, spinal cord motor neuron differentiation; MF: ATP binding, identical protein binding, kinase activity, protein binding; CC: Golgi apparatus, Golgi membrane, cell projection, cytoplasm, cytosol, endoplasmic reticulum, lamellipodium
Pathways:
UniProt: Q8IZE3
Entrez ID: 57147
|
Does Knockout of DUSP4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
DUSP4
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DUSP4 (dual specificity phosphatase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dephosphorylation, endoderm formation, negative regulation of ERK1 and ERK2 cascade, negative regulation of MAPK cascade, signal transduction; MF: MAP kinase phosphatase activity, MAP kinase serine/threonine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, ERK/MAPK targets, ERKs are inactivated, Endoderm differentiation, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of MAPK pathway, Nuclear Events (kinase and transcription factor activation), RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, regulation of map kinase pathways through dual specificity phosphatases
UniProt: Q13115
Entrez ID: 1846
|
Does Activation of TMEM60 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
TMEM60
|
protein/peptide accumulation
|
T cell
|
Gene: TMEM60 (transmembrane protein 60)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9H2L4
Entrez ID: 85025
|
Does Knockout of DHX37 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DHX37
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DHX37 (DEAH-box helicase 37)
Type: protein-coding
Summary: This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: brain development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of male gonad development, ribosomal small subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, U3 snoRNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: cytoplasm, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8IY37
Entrez ID: 57647
|
Does Knockout of LRRC8E in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
LRRC8E
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: LRRC8E (leucine rich repeat containing 8 VRAC subunit E)
Type: protein-coding
Summary: This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: aspartate transmembrane transport, cell volume homeostasis, cellular response to osmotic stress, cyclic-GMP-AMP transmembrane import across plasma membrane, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: protein binding, volume-sensitive anion channel activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q6NSJ5
Entrez ID: 80131
|
Does Knockout of EEFSEC in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
EEFSEC
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific)
Type: protein-coding
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: selenocysteine incorporation, translation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding, tRNA binding, translation elongation factor activity; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways: Metabolism, Metabolism of amino acids and derivatives, Selenoamino acid metabolism, Selenocysteine synthesis
UniProt: P57772
Entrez ID: 60678
|
Does Knockout of CTRB2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
CTRB2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: CTRB2 (chymotrypsinogen B2)
Type: protein-coding
Summary: This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB2 gene is located head-to-head with the related CTRB1 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 is diagnostic for this inversion. [provided by RefSeq, Jan 2021].
Gene Ontology: BP: digestion, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region
Pathways: Activation of Matrix Metalloproteinases, Cobalamin (Cbl, vitamin B12) transport and metabolism, Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pancreatic secretion - Homo sapiens (human), Protein digestion and absorption - Homo sapiens (human), Uptake of dietary cobalamins into enterocytes
UniProt: Q6GPI1
Entrez ID: 440387
|
Does Knockout of NKAIN2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
NKAIN2
|
response to virus
|
Huh-7 Cell
|
Gene: NKAIN2 (sodium/potassium transporting ATPase interacting 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q5VXU1
Entrez ID: 154215
|
Does Knockout of ATXN10 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
ATXN10
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: ATXN10 (ataxin 10)
Type: protein-coding
Summary: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell division, cilium assembly, nervous system development, neuron projection development, plasma membrane bounded cell projection organization, regulation of cytokinesis; CC: cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, extracellular space, membrane, midbody, neuronal cell body, perinuclear region of cytoplasm, plasma membrane
Pathways: Ciliopathies, Spinocerebellar ataxia - Homo sapiens (human)
UniProt: Q9UBB4
Entrez ID: 25814
|
Does Knockout of C17orf78 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
C17orf78
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: C17orf78 (chromosome 17 open reading frame 78)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N4C9
Entrez ID: 284099
|
Does Knockout of ALDOA in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
ALDOA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ALDOA (aldolase, fructose-bisphosphate A)
Type: protein-coding
Summary: This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: ATP biosynthetic process, actin filament organization, binding of sperm to zona pellucida, fructose 1,6-bisphosphate metabolic process, fructose metabolic process, glycolytic process, muscle cell cellular homeostasis, protein homotetramerization, regulation of cell shape, striated muscle contraction; MF: RNA binding, actin binding, cadherin binding, cytoskeletal protein binding, fructose binding, fructose-bisphosphate aldolase activity, identical protein binding, lyase activity, protein binding, tubulin binding; CC: I band, M band, actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, membrane, nucleus, platelet alpha granule lumen, secretory granule lumen, sperm head, tertiary granule lumen
Pathways: 16p11.2 proximal deletion syndrome, Computational Model of Aerobic Glycolysis, EGFR1, Fanconi-bickel syndrome, Fructose and Mannose Degradation, Fructose and mannose metabolism - Homo sapiens (human), Fructose intolerance, hereditary, Fructose-1,6-diphosphatase deficiency, Fructosuria, Gluconeogenesis, Glucose-6-phosphate dehydrogenase deficiency, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, Pathways in clear cell renal cell carcinoma, Pentose Phosphate Pathway, Pentose phosphate pathway - Homo sapiens (human), Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Ribose-5-phosphate isomerase deficiency, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Transaldolase deficiency, Triosephosphate isomerase, VEGFA-VEGFR2 Signaling Pathway, downregulated of mta-3 in er-negative breast tumors, gluconeogenesis, glycolysis, sucrose degradation, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P04075
Entrez ID: 226
|
Does Knockout of WDR46 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
WDR46
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: WDR46 (WD repeat domain 46)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O15213
Entrez ID: 9277
|
Does Knockout of MNAT1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
MNAT1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: MNAT1 (MNAT1 component of CDK activating kinase)
Type: protein-coding
Summary: The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: DNA repair, G1/S transition of mitotic cell cycle, adult heart development, negative regulation of apoptotic process, nucleotide-excision repair, positive regulation of smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of G1/S transition of mitotic cell cycle, regulation of transcription by RNA polymerase II, response to calcium ion, transcription initiation at RNA polymerase II promoter, ventricular system development; MF: cyclin-dependent protein serine/threonine kinase activator activity, metal ion binding, protein binding, zinc ion binding; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, DNA Repair Pathways Full Network, Disease, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, G1 Phase, G1 to S cell cycle control, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Retinoic acid receptors-mediated signaling, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, Viral Infection Pathways, mRNA Capping, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: P51948
Entrez ID: 4331
|
Does Knockout of EPHB3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
EPHB3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: EPHB3 (EPH receptor B3)
Type: protein-coding
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: angiogenesis, axon guidance, axonal fasciculation, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cell-substrate adhesion, central nervous system projection neuron axonogenesis, corpus callosum development, dendritic spine development, dendritic spine morphogenesis, digestive tract morphogenesis, ephrin receptor signaling pathway, nervous system development, positive regulation of synapse assembly, protein autophosphorylation, regulation of GTPase activity, regulation of axonogenesis, regulation of cell-cell adhesion, retinal ganglion cell axon guidance, roof of mouth development, substrate adhesion-dependent cell spreading, thymus development, urogenital system development; MF: ATP binding, axon guidance receptor activity, ephrin receptor activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: cell projection, cytosol, dendrite, extracellular region, membrane, plasma membrane
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Developmental Biology, EGFR1, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB forward signaling, EPHB-mediated forward signaling, Ephrin signaling, Nervous system development, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer
UniProt: P54753
Entrez ID: 2049
|
Does Knockout of LAMTOR1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
LAMTOR1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Type: protein-coding
Summary: Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TOR signaling; and regulation of cholesterol transport. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TORC1 signaling, autophagosome assembly, cellular response to amino acid stimulus, cellular response to nutrient levels, cholesterol homeostasis, cytoplasmic translation, endosomal transport, endosome organization, intracellular protein localization, lysosome localization, lysosome organization, negative regulation of autophagy, negative regulation of translational initiation, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of protein localization to lysosome, positive regulation of translational initiation, protein localization to lysosome, protein localization to membrane, regulation of cell growth, regulation of cholesterol efflux, regulation of cholesterol import, regulation of receptor recycling; MF: GTPase binding, guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding, protein-membrane adaptor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, azurophil granule membrane, endosome, extracellular exosome, ficolin-1-rich granule membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, membrane raft, plasma membrane, specific granule membrane
Pathways: Amino acids regulate mTORC1, Autophagy, CDC42 GTPase cycle, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Fibroblast growth factor-1, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q6IAA8
Entrez ID: 55004
|
Does Knockout of MRRF in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
MRRF
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRRF (mitochondrial ribosome recycling factor)
Type: protein-coding
Summary: This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: ribosome disassembly, translation; MF: protein binding, ribosomal large subunit binding; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q96E11
Entrez ID: 92399
|
Does Knockout of POLD1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
POLD1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: POLD1 (DNA polymerase delta 1, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling, response to UV; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, membrane, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cytosolic iron-sulfur cluster assembly, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Nucleotide metabolism, PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P28340
Entrez ID: 5424
|
Does Knockout of TMED7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TMED7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TMED7 (transmembrane p24 trafficking protein 7)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Regulation of toll-like receptor signaling pathway, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Y3B3
Entrez ID: 51014
|
Does Knockout of CENPI in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
CENPI
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: CENPI (centromere protein I)
Type: protein-coding
Summary: This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: CENP-A containing chromatin assembly, centromere complex assembly, chromosome segregation, mitotic sister chromatid segregation, sex differentiation; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q92674
Entrez ID: 2491
|
Does Knockout of CDH3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
CDH3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CDH3 (cadherin 3)
Type: protein-coding
Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015].
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, hair cycle process, homophilic cell adhesion via plasma membrane adhesion molecules, keratinization, negative regulation of timing of catagen, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of keratinocyte proliferation, positive regulation of melanin biosynthetic process, positive regulation of melanosome transport, positive regulation of tyrosinase activity, regulation of transport, retina homeostasis, visual perception; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, cell junction, cytoplasm, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, EGFR1, Hippo-Merlin Signaling Dysregulation, Overview of nanoparticle effects, Pathways Regulating Hippo Signaling
UniProt: P22223
Entrez ID: 1001
|
Does Knockout of TMEM258 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
TMEM258
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TMEM258 (transmembrane protein 258)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epithelial cell apoptotic process, inflammatory response, protein N-linked glycosylation, protein glycosylation, response to endoplasmic reticulum stress; MF: oligosaccharyltransferase complex binding, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: P61165
Entrez ID: 746
|
Does Knockout of COX7B in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
COX7B
|
cell proliferation
|
Cancer Cell Line
|
Gene: COX7B (cytochrome c oxidase subunit 7B)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: cellular respiration, central nervous system development, mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation, proton transmembrane transport; MF: cytochrome-c oxidase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial CIV Assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Homo sapiens (human), Transcriptional Regulation by TP53
UniProt: P24311
Entrez ID: 1349
|
Does Knockout of DERL2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
DERL2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DERL2 (derlin 2)
Type: protein-coding
Summary: Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum unfolded protein response, negative regulation of retrograde protein transport, ER to cytosol, positive regulation of cell growth, positive regulation of cell population proliferation, response to unfolded protein, retrograde protein transport, ER to cytosol, suckling behavior; MF: protein binding, protein-containing complex binding, signal recognition particle binding; CC: early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, late endosome, membrane
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, ER Quality Control Compartment (ERQC), Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Hedgehog, Transport of small molecules
UniProt: Q9GZP9
Entrez ID: 51009
|
Does Knockout of CHIC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
CHIC1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CHIC1 (cysteine rich hydrophobic domain 1)
Type: protein-coding
Summary: This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene is subject to X-inactivation in mouse. Experiments with other CHIC domain-containing family members show that the cysteine residues are palmitoylated post-translationally, resulting in membrane association. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: CC: cytoplasmic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q5VXU3
Entrez ID: 53344
|
Does Knockout of PHF3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
PHF3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: PHF3 (PHD finger protein 3)
Type: protein-coding
Summary: This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q92576
Entrez ID: 23469
|
Does Knockout of NCS1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
NCS1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NCS1 (neuronal calcium sensor 1)
Type: protein-coding
Summary: This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, regulation of neuron projection development, regulation of signal transduction; MF: calcium ion binding, calcium sensitive guanylate cyclase activator activity, metal ion binding, protein binding, voltage-gated calcium channel activity; CC: Golgi apparatus, axon, cytoplasm, cytosol, dendrite, membrane, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, synapse
Pathways: regulation of ck1/cdk5 by type 1 glutamate receptors
UniProt: P62166
Entrez ID: 23413
|
Does Knockout of RPP38 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
RPP38
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RPP38 (ribonuclease P/MRP subunit p38)
Type: protein-coding
Summary: Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in fibrillar center. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: RNA binding, protein binding, ribonuclease P RNA binding, ribonuclease P activity; CC: fibrillar center, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonuclease MRP complex
Pathways: Integrated breast cancer pathway, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol, tRNA processing, tRNA processing in the nucleus
UniProt: P78345
Entrez ID: 10557
|
Does Knockout of ARIH1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
ARIH1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: PKR/eIFalpha signaling, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Cajal body, Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Lewy body, SCF ubiquitin ligase complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, ISG15 antiviral mechanism, Immune System, Infectious disease, Interferon Signaling, Modulation of host responses by IFN-stimulated genes, PKR-mediated signaling, RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Viral Infection Pathways
UniProt: Q9Y4X5
Entrez ID: 25820
|
Does Knockout of SLC25A12 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SLC25A12
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SLC25A12 (solute carrier family 25 member 12)
Type: protein-coding
Summary: This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: L-aspartate transmembrane transport, L-glutamate transmembrane transport, aspartate transmembrane transport, malate-aspartate shuttle, neutral amino acid transport, proton transmembrane transport, response to calcium ion, transmembrane transport; MF: 3-sulfino-L-alanine: proton, glutamate antiporter activity, L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, acidic amino acid transmembrane transporter activity, aspartate:glutamate, proton antiporter activity, calcium ion binding, identical protein binding, metal ion binding, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Argininemia, Argininosuccinic Aciduria, Aspartate and asparagine metabolism, Carbamoyl Phosphate Synthetase Deficiency, Citrullinemia Type I, Malate-Aspartate Shuttle, Malate-aspartate shuttle, Metabolism, Metabolism of amino acids and derivatives, Mitochondrial protein import, Ornithine Transcarbamylase Deficiency (OTC Deficiency), Protein localization, Respiratory electron transport, Urea Cycle
UniProt: O75746
Entrez ID: 8604
|
Does Knockout of PRPF8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
PRPF8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PRPF8 (pre-mRNA processing factor 8)
Type: protein-coding
Summary: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, mRNA processing, mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: K63-linked polyubiquitin modification-dependent protein binding, RNA binding, U1 snRNA binding, U2 snRNA binding, U5 snRNA binding, U6 snRNA binding, metal-dependent deubiquitinase activity, peptidase activity, pre-mRNA intronic binding, protein binding; CC: U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, membrane, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q6P2Q9
Entrez ID: 10594
|
Does Knockout of FYN in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
FYN
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: FYN (FYN proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled glutamate receptor signaling pathway, T cell costimulation, T cell receptor signaling pathway, activated T cell proliferation, adaptive immune response, axon guidance, calcium ion transport, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cellular response to L-glutamate, cellular response to amyloid-beta, cellular response to glycine, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to peptide hormone stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to transforming growth factor beta stimulus, dendrite morphogenesis, dendritic spine maintenance, detection of mechanical stimulus involved in sensory perception of pain, ephrin receptor signaling pathway, feeding behavior, forebrain development, gene expression, heart process, immune system process, intracellular signal transduction, layer formation in cerebral cortex, learning, leukocyte migration, modulation of chemical synaptic transmission, natural killer cell activation, negative regulation of angiogenesis, negative regulation of dendritic spine maintenance, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gene expression, negative regulation of hydrogen peroxide biosynthetic process, negative regulation of inflammatory response to antigenic stimulus, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein catabolic process, negative regulation of protein ubiquitination, neuron migration, neuron projection development, peptidyl-tyrosine phosphorylation, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to membrane, positive regulation of protein localization to nucleus, positive regulation of protein targeting to membrane, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, reelin-mediated signaling pathway, regulation of calcium ion import across plasma membrane, regulation of cell shape, regulation of glutamate receptor signaling pathway, regulation of neuron migration, response to amyloid-beta, response to cocaine, response to ethanol, response to singlet oxygen, response to xenobiotic stimulus, stimulatory C-type lectin receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway; MF: ATP binding, CD4 receptor binding, CD8 receptor binding, G protein-coupled receptor binding, T cell receptor binding, alpha-tubulin binding, disordered domain specific binding, enzyme binding, ephrin receptor binding, growth factor receptor binding, identical protein binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, phospholipase activator activity, phospholipase binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, scaffold protein binding, signaling receptor binding, tau protein binding, tau-protein kinase activity, transferase activity, transmembrane transporter binding, tubulin binding, type 5 metabotropic glutamate receptor binding; CC: Schaffer collateral - CA1 synapse, actin filament, cell body, cell periphery, cytoplasm, cytosol, dendrite, endosome, glial cell projection, glutamatergic synapse, membrane, membrane raft, mitochondrion, nucleus, perikaryon, perinuclear endoplasmic reticulum, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic density, intracellular component
Pathways: 15q13.3 copy number variation syndrome, Acute viral myocarditis, Adherens junction - Homo sapiens (human), Alpha-synuclein signaling, Alpha6Beta4Integrin, Angiopoietin receptor Tie2-mediated signaling, Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, BCR, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR4-mediated signaling events, Cholinergic synapse - Homo sapiens (human), Class I PI3K signaling events, E-cadherin signaling in keratinocytes, EGFR1, EPHA forward signaling, Ectoderm Differentiation, Ephrin A reverse signaling, Ephrin B reverse signaling, ErbB4 signaling events, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Focal Adhesion, Focal adhesion - Homo sapiens (human), Fragile X Syndrome, Gastrin signaling pathway, Ghrelin, Glypican 1 network, IL-2 signaling pathway, IL-3 signaling pathway, IL-7, IL-7 signaling pathway, IL2, IL2-mediated signaling events, IL6, Integrin-mediated Cell Adhesion, Interferon type I signaling pathways, Interleukin-11 Signaling Pathway, Kit receptor signaling pathway, KitReceptor, Leptin, Leptin signaling pathway, NRF2-ARE regulation, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nephrin/Neph1 signaling in the kidney podocyte, Netrin-UNC5B signaling pathway, Netrin-mediated signaling events, Osteoclast differentiation - Homo sapiens (human), PDGFR-beta signaling pathway, Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation - Homo sapiens (human), Posttranslational regulation of adherens junction stability and dissassembly, Primary focal segmental glomerulosclerosis (FSGS), Prion disease - Homo sapiens (human), Prion disease pathway, Prolactin, Prolactin Signaling Pathway, Reelin signaling pathway, Regulation of p38-alpha and p38-beta, Signaling events mediated by PTP1B, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Sphingolipid signaling pathway - Homo sapiens (human), Syndecan-3-mediated signaling events, T cell receptor signaling pathway - Homo sapiens (human), T-Cell Receptor and Co-stimulatory Signaling, T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, Thromboxane A2 receptor signaling, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, VEGFA-VEGFR2 Signaling Pathway, Viral myocarditis - Homo sapiens (human), bioactive peptide induced signaling pathway, il-7 signal transduction, integrin signaling pathway, lck and fyn tyrosine kinases in initiation of tcr activation, role of mef2d in t-cell apoptosis, t cell receptor signaling pathway, tsp-1 induced apoptosis in microvascular endothelial cell
UniProt: P06241
Entrez ID: 2534
|
Does Knockout of CACNA1G in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
CACNA1G
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CACNA1G (calcium voltage-gated channel subunit alpha1 G)
Type: protein-coding
Summary: Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: AV node cell action potential, AV node cell to bundle of His cell signaling, SA node cell action potential, SA node cell to atrial cardiac muscle cell signaling, action potential, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cardiac muscle cell action potential involved in contraction, chemical synaptic transmission, membrane depolarization during AV node cell action potential, membrane depolarization during SA node cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of atrial cardiac muscle cell membrane depolarization, regulation of biological quality, regulation of heart rate, regulation of heart rate by cardiac conduction, regulation of membrane potential, response to nickel cation, sinoatrial node development, transmembrane transport; MF: calcium channel activity, high voltage-gated calcium channel activity, low voltage-gated calcium channel activity, monoatomic ion channel activity, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved SA node cell action potential, voltage-gated calcium channel activity involved in AV node cell action potential; CC: cytoplasm, membrane, monoatomic ion channel complex, plasma membrane, synapse, voltage-gated calcium channel complex
Pathways: Acebutolol Action Pathway, Aldosterone synthesis and secretion - Homo sapiens (human), Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Axon guidance, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Calcium signaling pathway - Homo sapiens (human), Carteolol Action Pathway, Carvedilol Action Pathway, Circadian entrainment - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Developmental Biology, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, GnRH secretion - Homo sapiens (human), Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, NCAM signaling for neurite out-growth, NCAM1 interactions, Nadolol Action Pathway, Nebivolol Action Pathway, Nervous system development, Nicotine Activity on Chromaffin Cells, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Regulation of nuclear beta catenin signaling and target gene transcription, Smooth Muscle Contraction, Sotalol Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Type II diabetes mellitus - Homo sapiens (human), Verapamil Action Pathway
UniProt: O43497
Entrez ID: 8913
|
Does Knockout of TCF4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
TCF4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TCF4 (transcription factor 4)
Type: protein-coding
Summary: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: cell differentiation, nervous system development, positive regulation of DNA-templated transcription, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, protein-DNA complex assembly, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, TFIIB-class transcription factor binding, beta-catenin binding, identical protein binding, protein binding, protein dimerization activity, protein heterodimerization activity, sequence-specific double-stranded DNA binding; CC: beta-catenin-TCF complex, beta-catenin-TCF7L2 complex, chromatin, nucleus, transcription regulator complex
Pathways: AndrogenReceptor, Coregulation of Androgen receptor activity, Corticotropin-releasing hormone signaling pathway, Development of pulmonary dendritic cells and macrophage subsets, Gastrin, Gastrin signaling pathway, Mesodermal commitment pathway, Neural Crest Differentiation, Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds, Regulation of nuclear beta catenin signaling and target gene transcription, Rett syndrome causing genes, Wnt, Wnt Signaling Pathway
UniProt: P15884
Entrez ID: 6925
|
Does Knockout of GINS4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
GINS4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: GINS4 (GINS complex subunit 4)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, double-strand break repair via break-induced replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9BRT9
Entrez ID: 84296
|
Does Knockout of EIF5 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
EIF5
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: EIF5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010].
Gene Ontology: BP: formation of cytoplasmic translation initiation complex, regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: GDP-dissociation inhibitor activity, GTP binding, GTPase activator activity, RNA binding, cadherin binding, eukaryotic initiation factor eIF2 binding, nucleotide binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, nucleus, plasma membrane, synapse
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell, regulation of eif2
UniProt: P55010
Entrez ID: 1983
|
Does Knockout of MRPL21 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
MRPL21
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: MRPL21 (mitochondrial ribosomal protein L21)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q7Z2W9
Entrez ID: 219927
|
Does Activation of GLCCI1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
GLCCI1
|
protein/peptide accumulation
|
T cell
|
Gene: GLCCI1 (glucocorticoid induced 1)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012].
Gene Ontology:
Pathways:
UniProt: Q86VQ1
Entrez ID: 113263
|
Does Knockout of ANKMY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
ANKMY2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: ANKMY2 (ankyrin repeat and MYND domain containing 2)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity and metal ion binding activity. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: enzyme binding, metal ion binding, protein binding, zinc ion binding; CC: cell projection, cilium
Pathways:
UniProt: Q8IV38
Entrez ID: 57037
|
Does Knockout of HAUS4 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
HAUS4
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: HAUS4 (HAUS augmin like complex subunit 4)
Type: protein-coding
Summary: This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; MF: microtubule minus-end binding, protein binding; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9H6D7
Entrez ID: 54930
|
Does Knockout of MTRF1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
MTRF1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MTRF1 (mitochondrial translation release factor 1)
Type: protein-coding
Summary: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translational termination, translation, translational termination; MF: translation release factor activity, translation release factor activity, codon specific; CC: cytoplasm, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: O75570
Entrez ID: 9617
|
Does Knockout of ZNF112 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
ZNF112
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ZNF112 (zinc finger protein 112)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UJU3
Entrez ID: 7771
|
Does Knockout of MDN1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
MDN1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MDN1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding; CC: cytoplasm, cytosol, intermediate filament cytoskeleton, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9NU22
Entrez ID: 23195
|
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