prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of GLT8D2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | GLT8D2 | cell proliferation | Colonic Cancer Cell Line | Gene: GLT8D2 (glycosyltransferase 8 domain containing 2)
Type: protein-coding
Summary: Predicted to enable glycosyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of SRSF6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | SRSF6 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SRSF6 (serine and arginine rich splicing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown t... |
Does Knockout of BCCIP in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | BCCIP | cell proliferation | Multiple Myeloma Cell Line | Gene: BCCIP (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology w... |
Does Knockout of TUBGCP2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | TUBGCP2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TUBGCP2 (tubulin gamma complex component 2)
Type: protein-coding
Summary: Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome and nucleoplasm. [provided by A... |
Does Knockout of KCP in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | KCP | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: KCP (kielin cysteine rich BMP regulator)
Type: protein-coding
Summary: Predicted to act upstream of or within hematopoietic progenitor cell differentiation and positive regulation of BMP signaling pathway. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, A... |
Does Knockout of TOP3A in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | TOP3A | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: TOP3A (DNA topoisomerase III alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strand... |
Does Knockout of SMC4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | SMC4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome cond... |
Does Knockout of TBC1D3F in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | TBC1D3F | cell proliferation | Cancer Cell Line | Gene: TBC1D3F (TBC1 domain family member 3F)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, ... |
Does Knockout of TWIST2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | TWIST2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TWIST2 (twist family bHLH transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype du... |
Does Knockout of CD58 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | CD58 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: CD58 (CD58 molecule)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternativel... |
Does Knockout of FBXO2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | FBXO2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: FBXO2 (F-box protein 2)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-c... |
Does Knockout of PPARGC1B in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | PPARGC1B | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PPARGC1B (PPARG coactivator 1 beta)
Type: protein-coding
Summary: The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may b... |
Does Activation of PDE10A in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | PDE10A | protein/peptide accumulation | T cell | Gene: PDE10A (phosphodiesterase 10A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP ... |
Does Knockout of FOXRED1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | FOXRED1 | cell proliferation | Gastric Cancer Cell Line | Gene: FOXRED1 (FAD dependent oxidoreductase domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitoch... |
Does Knockout of RFC5 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RFC5 | cell proliferation | Medulloblastoma Cell Line | Gene: RFC5 (replication factor C subunit 5)
Type: protein-coding
Summary: This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal reg... |
Does Knockout of KYAT3 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | KYAT3 | cell proliferation | Gastric Cancer Cell Line | Gene: KYAT3 (kynurenine aminotransferase 3)
Type: protein-coding
Summary: This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described... |
Does Knockout of TUSC3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | TUSC3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: TUSC3 (tumor suppressor candidate 3)
Type: protein-coding
Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and ac... |
Does Knockout of LRR1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | LRR1 | cell proliferation | Multiple Myeloma Cell Line | Gene: LRR1 (leucine rich repeat protein 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the acti... |
Does Knockout of SMIM2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | SMIM2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SMIM2 (small integral membrane protein 2)
Type: ncRNA
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 79024 |
Does Knockout of SLC32A1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | SLC32A1 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: SLC32A1 (solute carrier family 32 member 1)
Type: protein-coding
Summary: The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter famil... |
Does Knockout of RP9 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | RP9 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: RP9 (RP9 pre-mRNA splicing factor)
Type: protein-coding
Summary: The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre... |
Does Knockout of TMEM198 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | TMEM198 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TMEM198 (transmembrane protein 198)
Type: protein-coding
Summary: Involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Wnt signaling pathway, positive... |
Does Knockout of RPL7A in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | RPL7A | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: RPL7A (ribosomal protein L7a)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gen... |
Does Knockout of OR6C65 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | OR6C65 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: OR6C65 (olfactory receptor family 6 subfamily C member 65)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of MYBL2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | MYBL2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: MYBL2 (MYB proto-oncogene like 2)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during th... |
Does Knockout of OR52B4 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | OR52B4 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: OR52B4 (olfactory receptor family 52 subfamily B member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of ALG11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | ALG11 | cell proliferation | Medulloblastoma Cell Line | Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue f... |
Does Knockout of CCT2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | CCT2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CCT2 (chaperonin containing TCP1 subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea... |
Does Knockout of CEND1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | CEND1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CEND1 (cell cycle exit and neuronal differentiation 1)
Type: protein-coding
Summary: The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseu... |
Does Knockout of HTR5A in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | HTR5A | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: HTR5A (5-hydroxytryptamine receptor 5A)
Type: protein-coding
Summary: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-... |
Does Knockout of COL21A1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | COL21A1 | cell proliferation | Melanoma Cell Line | Gene: COL21A1 (collagen type XXI alpha 1 chain)
Type: protein-coding
Summary: This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and mai... |
Does Knockout of RAB9B in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | RAB9B | response to virus | Hepatoma Cell Line | Gene: RAB9B (RAB9B, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, ... |
Does Knockout of PSMB9 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | PSMB9 | cell proliferation | Monocytic Leukemia Cell Line | Gene: PSMB9 (proteasome 20S subunit beta 9)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of MAST2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | MAST2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MAST2 (microtubule associated serine/threonine kinase 2)
Type: protein-coding
Summary: Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted t... |
Does Knockout of RIBC1 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | RIBC1 | response to chemicals | Prostate Cancer Cell Line | Gene: RIBC1 (RIB43A domain with coiled-coils 1)
Type: protein-coding
Summary: Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance... |
Does Knockout of ATP2A3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | ATP2A3 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)
Type: protein-coding
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP cou... |
Does Knockout of GTF2B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | GTF2B | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) w... |
Does Activation of PPP4R3A in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | PPP4R3A | response to virus | Hepatoma Cell Line | Gene: PPP4R3A (protein phosphatase 4 regulatory subunit 3A)
Type: protein-coding
Summary: Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene ... |
Does Knockout of PYURF in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | PYURF | cell proliferation | Melanoma Cell Line | Gene: PYURF (PIGY upstream open reading frame)
Type: protein-coding
Summary: The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents th... |
Does Knockout of SERP1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | SERP1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: SERP1 (stress associated endoplasmic reticulum protein 1)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum unfolded protein response and protein glycosylation. Predicted to act upstream of or within several processes, including multicellular organism aging; positive ... |
Does Knockout of NAA15 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | NAA15 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino grou... |
Does Knockout of ANAPC2 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | ANAPC2 | cell proliferation | Glioblastoma Cell Line | Gene: ANAPC2 (anaphase promoting complex subunit 2)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which... |
Does Knockout of MANSC4 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | MANSC4 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MANSC4 (MANSC domain containing 4)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, epithelium development, extracellular matrix organization; CC: membrane, plasma m... |
Does Knockout of LIMK1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | LIMK1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: LIMK1 (LIM domain kinase 1)
Type: protein-coding
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to D... |
Does Knockout of MIR4493 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MIR4493 | response to chemicals | Glioblastoma Cell Line | Gene: MIR4493 (microRNA 4493)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of MED22 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | MED22 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MED22 (mediator complex subunit 22)
Type: protein-coding
Summary: This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factor... |
Does Knockout of CPNE7 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | CPNE7 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CPNE7 (copine 7)
Type: protein-coding
Summary: This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membr... |
Does Knockout of ERLIN1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ERLIN1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ERLIN1 (ER lipid raft associated 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signa... |
Does Knockout of CNOT10 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | CNOT10 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CNOT10 (CCR4-NOT transcription complex subunit 10)
Type: protein-coding
Summary: Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP... |
Does Knockout of DCTN2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | DCTN2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: DCTN2 (dynactin subunit 2)
Type: protein-coding
Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular... |
Does Knockout of SCN5A in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | SCN5A | response to chemicals | Monocytic Leukemia Cell Line | Gene: SCN5A (sodium voltage-gated channel alpha subunit 5)
Type: protein-coding
Summary: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial ... |
Does Knockout of TADA3 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | TADA3 | cell proliferation | Cancer Cell Line | Gene: TADA3 (transcriptional adaptor 3)
Type: protein-coding
Summary: DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabil... |
Does Knockout of PAXBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | PAXBP1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: PAXBP1 (PAX3 and PAX7 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefS... |
Does Knockout of CENPH in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | CENPH | cell proliferation | Monocytic Leukemia Cell Line | Gene: CENPH (centromere protein H)
Type: protein-coding
Summary: Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C ... |
Does Knockout of PDCL in Glioma Cell Line causally result in protein/peptide accumulation? | 1 | 589 | Knockout | PDCL | protein/peptide accumulation | Glioma Cell Line | Gene: PDCL (phosducin like)
Type: protein-coding
Summary: Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphod... |
Does Knockout of PPP1R2 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | PPP1R2 | cell proliferation | Renal Cancer Cell Line | Gene: PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)
Type: protein-coding
Summary: Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related... |
Does Knockout of SAMD4B in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SAMD4B | cell proliferation | Monocytic Leukemia Cell Line | Gene: SAMD4B (sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Allianc... |
Does Knockout of SLC6A1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | SLC6A1 | cell proliferation | Gastric Cancer Cell Line | Gene: SLC6A1 (solute carrier family 6 member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided... |
Does Knockout of SCYL3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SCYL3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SCYL3 (SCY1 like pseudokinase 3)
Type: protein-coding
Summary: This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results... |
Does Knockout of DUSP4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | DUSP4 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: DUSP4 (dual specificity phosphatase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine resi... |
Does Activation of TMEM60 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | TMEM60 | protein/peptide accumulation | T cell | Gene: TMEM60 (transmembrane protein 60)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9H2L4
Entrez ID: 85025 |
Does Knockout of DHX37 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | DHX37 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DHX37 (DEAH-box helicase 37)
Type: protein-coding
Summary: This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary s... |
Does Knockout of LRRC8E in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | LRRC8E | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: LRRC8E (leucine rich repeat containing 8 VRAC subunit E)
Type: protein-coding
Summary: This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell developm... |
Does Knockout of EEFSEC in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | EEFSEC | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific)
Type: protein-coding
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucl... |
Does Knockout of CTRB2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | CTRB2 | cell proliferation | Hepatoma Cell Line | Gene: CTRB2 (chymotrypsinogen B2)
Type: protein-coding
Summary: This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the sm... |
Does Knockout of NKAIN2 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | NKAIN2 | response to virus | Huh-7 Cell | Gene: NKAIN2 (sodium/potassium transporting ATPase interacting 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative sp... |
Does Knockout of ATXN10 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | ATXN10 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: ATXN10 (ataxin 10)
Type: protein-coding
Summary: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copie... |
Does Knockout of C17orf78 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | C17orf78 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: C17orf78 (chromosome 17 open reading frame 78)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N4C9
Entrez ID: 284099 |
Does Knockout of ALDOA in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | ALDOA | cell proliferation | Medulloblastoma Cell Line | Gene: ALDOA (aldolase, fructose-bisphosphate A)
Type: protein-coding
Summary: This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phos... |
Does Knockout of WDR46 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | WDR46 | cell proliferation | Monocytic Leukemia Cell Line | Gene: WDR46 (WD repeat domain 46)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Pr... |
Does Knockout of MNAT1 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | MNAT1 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: MNAT1 (MNAT1 component of CDK activating kinase)
Type: protein-coding
Summary: The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to acti... |
Does Knockout of EPHB3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | EPHB3 | cell proliferation | Endometrial Cancer Cell Line | Gene: EPHB3 (EPH receptor B3)
Type: protein-coding
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are a... |
Does Knockout of LAMTOR1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | LAMTOR1 | cell proliferation | Colorectal Cancer Cell Line | Gene: LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Type: protein-coding
Summary: Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive ... |
Does Knockout of MRRF in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | MRRF | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MRRF (mitochondrial ribosome recycling factor)
Type: protein-coding
Summary: This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the ... |
Does Knockout of POLD1 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | POLD1 | cell proliferation | Prostate Cancer Cell Line | Gene: POLD1 (DNA polymerase delta 1, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alterna... |
Does Knockout of TMED7 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | TMED7 | cell proliferation | Endometrial Cancer Cell Line | Gene: TMED7 (transmembrane p24 trafficking protein 7)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum... |
Does Knockout of CENPI in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | CENPI | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: CENPI (centromere protein I)
Type: protein-coding
Summary: This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein... |
Does Knockout of CDH3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | CDH3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CDH3 (cadherin 3)
Type: protein-coding
Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. Thi... |
Does Knockout of TMEM258 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | TMEM258 | cell proliferation | Gastric Cancer Cell Line | Gene: TMEM258 (transmembrane protein 258)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epithelial cell apoptotic pr... |
Does Knockout of COX7B in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | COX7B | cell proliferation | Cancer Cell Line | Gene: COX7B (cytochrome c oxidase subunit 7B)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic su... |
Does Knockout of DERL2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | DERL2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: DERL2 (derlin 2)
Type: protein-coding
Summary: Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]... |
Does Knockout of CHIC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | CHIC1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CHIC1 (cysteine rich hydrophobic domain 1)
Type: protein-coding
Summary: This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene i... |
Does Knockout of PHF3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | PHF3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: PHF3 (PHD finger protein 3)
Type: protein-coding
Summary: This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by... |
Does Knockout of NCS1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | NCS1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NCS1 (neuronal calcium sensor 1)
Type: protein-coding
Summary: This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calc... |
Does Knockout of RPP38 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | RPP38 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RPP38 (ribonuclease P/MRP subunit p38)
Type: protein-coding
Summary: Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in fibrillar center. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Reso... |
Does Knockout of ARIH1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | ARIH1 | cell proliferation | Multiple Myeloma Cell Line | Gene: ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RIN... |
Does Knockout of SLC25A12 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SLC25A12 | cell proliferation | Glioblastoma Cell Line | Gene: SLC25A12 (solute carrier family 25 member 12)
Type: protein-coding
Summary: This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polym... |
Does Knockout of PRPF8 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | PRPF8 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PRPF8 (pre-mRNA processing factor 8)
Type: protein-coding
Summary: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicin... |
Does Knockout of FYN in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | FYN | RNA accumulation | Monocytic Leukemia Cell Line | Gene: FYN (FYN proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subu... |
Does Knockout of CACNA1G in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | CACNA1G | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: CACNA1G (calcium voltage-gated channel subunit alpha1 G)
Type: protein-coding
Summary: Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmi... |
Does Knockout of TCF4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | TCF4 | cell proliferation | Colonic Cancer Cell Line | Gene: TCF4 (transcription factor 4)
Type: protein-coding
Summary: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is... |
Does Knockout of GINS4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | GINS4 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: GINS4 (GINS complex subunit 4)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast a... |
Does Knockout of EIF5 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | EIF5 | cell proliferation | Renal Cancer Cell Line | Gene: EIF5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The re... |
Does Knockout of MRPL21 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | MRPL21 | cell proliferation | Breast Cancer Cell Line | Gene: MRPL21 (mitochondrial ribosomal protein L21)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Activation of GLCCI1 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | GLCCI1 | protein/peptide accumulation | T cell | Gene: GLCCI1 (glucocorticoid induced 1)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a... |
Does Knockout of ANKMY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | ANKMY2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: ANKMY2 (ankyrin repeat and MYND domain containing 2)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity and metal ion binding activity. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: enzyme binding, metal i... |
Does Knockout of HAUS4 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | HAUS4 | cell proliferation | Astrocytoma Cell Line | Gene: HAUS4 (HAUS augmin like complex subunit 4)
Type: protein-coding
Summary: This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome in... |
Does Knockout of MTRF1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | MTRF1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MTRF1 (mitochondrial translation release factor 1)
Type: protein-coding
Summary: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release... |
Does Knockout of ZNF112 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | ZNF112 | cell proliferation | Multiple Myeloma Cell Line | Gene: ZNF112 (zinc finger protein 112)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of MDN1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | MDN1 | cell proliferation | Astrocytoma Cell Line | Gene: MDN1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
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