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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of AFDN in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
AFDN
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: AFDN (afadin, adherens junction formation factor)
Type: protein-coding
Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].
Gene Ontology: BP: bicellular tight junction assembly, cell adhesion, cell differentiation, cell junction organization, cell-cell adhesion mediated by cadherin, cell-cell signaling, establishment of endothelial intestinal barrier, establishment of protein localization to plasma membrane, negative regulation of cell migration, pore complex assembly, positive regulation of cell-cell adhesion, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of gene expression, regulation of protein localization, signal transduction; MF: actin filament binding, cadherin binding, cell adhesion molecule binding, protein binding, small GTPase binding; CC: adherens junction, anchoring junction, cell junction, cell-cell contact zone, cell-cell junction, cytoplasm, cytosol, nuclear speck, nucleoplasm, plasma membrane, pore complex, tight junction
Pathways: 1q21.1 copy number variation syndrome, Adherens junction - Homo sapiens (human), Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, E-cadherin signaling in the nascent adherens junction, Leukocyte transendothelial migration - Homo sapiens (human), Nectin adhesion pathway, PDGFR-beta signaling pathway, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), SHP2 signaling, Stabilization and expansion of the E-cadherin adherens junction, Tight junction - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, cAMP signaling pathway - Homo sapiens (human)
UniProt: P55196
Entrez ID: 4301
|
Does Knockout of LCE6A in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
LCE6A
|
cell proliferation
|
Cancer Cell Line
|
Gene: LCE6A (late cornified envelope 6A)
Type: protein-coding
Summary: Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: A0A183
Entrez ID: 448835
|
Does Knockout of SH3BP5L in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
SH3BP5L
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SH3BP5L (SH3 binding domain protein 5 like)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction and negative regulation of protein tyrosine kinase activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding, protein kinase inhibitor activity
Pathways:
UniProt: Q7L8J4
Entrez ID: 80851
|
Does Knockout of DMTN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
DMTN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DMTN (dematin actin binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, actin filament capping, cellular response to cAMP, cytoskeleton organization, endoplasmic reticulum tubular network organization, erythrocyte development, lamellipodium assembly, negative regulation of cell-substrate adhesion, negative regulation of focal adhesion assembly, negative regulation of peptidyl-serine phosphorylation, negative regulation of peptidyl-threonine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein targeting to membrane, negative regulation of substrate adhesion-dependent cell spreading, positive regulation of fibroblast migration, positive regulation of wound healing, protein-containing complex assembly, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of filopodium assembly, regulation of lamellipodium assembly, smooth endoplasmic reticulum calcium ion homeostasis; MF: actin binding, actin filament binding, protein binding, signaling receptor binding, spectrin binding; CC: actin cytoskeleton, actin filament, cell projection, cell projection membrane, cortical cytoskeleton, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endomembrane system, membrane, perinuclear region of cytoplasm, plasma membrane, platelet dense tubular network membrane, postsynaptic density, smooth endoplasmic reticulum, spectrin-associated cytoskeleton, synapse
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q08495
Entrez ID: 2039
|
Does Activation of SH2B3 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
SH2B3
|
protein/peptide accumulation
|
T cell
|
Gene: SH2B3 (SH2B adaptor protein 3)
Type: protein-coding
Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, cellular response to chemokine, cellular response to interleukin-3, embryonic hemopoiesis, erythrocyte development, hematopoietic stem cell differentiation, hemopoiesis, intracellular signal transduction, megakaryocyte development, monocyte homeostasis, myeloid cell development, myeloid cell homeostasis, negative regulation of Kit signaling pathway, negative regulation of MAPK cascade, negative regulation of cell population proliferation, negative regulation of chemokine-mediated signaling pathway, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of platelet aggregation, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of receptor signaling pathway via STAT, negative regulation of response to cytokine stimulus, neutrophil homeostasis, signal transduction, thrombopoietin-mediated signaling pathway; MF: protein binding, protein tyrosine kinase binding, signaling adaptor activity, signaling receptor complex adaptor activity, stem cell factor receptor binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytosol, plasma membrane
Pathways: Cytokine Signaling in Immune system, EPO signaling pathway, FLT3 Signaling, Factors involved in megakaryocyte development and platelet production, Hemostasis, Immune System, Modulators of TCR signaling and T cell activation, Negative regulation of FLT3, Neurotrophin signaling pathway - Homo sapiens (human), Regulation of KIT signaling, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling events mediated by Stem cell factor receptor (c-Kit), T-cell receptor (TCR) signaling pathway, TCR, TYROBP causal network in microglia
UniProt: Q9UQQ2
Entrez ID: 10019
|
Does Knockout of POLE3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
POLE3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: POLE3 (DNA polymerase epsilon 3, accessory subunit)
Type: protein-coding
Summary: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA replication, DNA-templated DNA replication, chromatin remodeling, heterochromatin formation, leading strand elongation, negative regulation of transcription by RNA polymerase II, nucleosome assembly, regulation of DNA replication; MF: DNA binding, DNA-directed DNA polymerase activity, chromatin DNA binding, protein binding, protein heterodimerization activity; CC: ATAC complex, CHRAC, chromatin, epsilon DNA polymerase complex, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9NRF9
Entrez ID: 54107
|
Does Knockout of INS in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
INS
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: INS (insulin)
Type: protein-coding
Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, TORC1 signaling, acute-phase response, alpha-beta T cell activation, cell-cell signaling, cellular response to oxygen-containing compound, cognition, fatty acid homeostasis, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, negative regulation of acute inflammatory response, negative regulation of fatty acid metabolic process, negative regulation of feeding behavior, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of glycogen catabolic process, negative regulation of lipid catabolic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein catabolic process, negative regulation of protein secretion, negative regulation of reactive oxygen species biosynthetic process, negative regulation of respiratory burst involved in inflammatory response, negative regulation of ubiquitin-dependent protein catabolic process, neuron projection maintenance, nitric oxide-cGMP-mediated signaling, positive regulation of D-glucose import, positive regulation of MAPK cascade, positive regulation of brown fat cell differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell differentiation, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of dendritic spine maintenance, positive regulation of gene expression, positive regulation of glycogen biosynthetic process, positive regulation of glycolytic process, positive regulation of insulin receptor signaling pathway, positive regulation of lipid biosynthetic process, positive regulation of long-term synaptic potentiation, positive regulation of mitotic nuclear division, positive regulation of neuron projection development, positive regulation of nitric oxide mediated signal transduction, positive regulation of nitric-oxide synthase activity, positive regulation of peptide hormone secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein secretion, positive regulation of respiratory burst, positive regulation of translation, regulation of DNA-templated transcription, regulation of protein localization, regulation of protein localization to plasma membrane, regulation of protein secretion, regulation of synaptic plasticity, vasodilation, wound healing; MF: hormone activity, identical protein binding, insulin receptor binding, insulin-like growth factor receptor binding, protease binding, protein binding, receptor ligand activity; CC: Golgi lumen, Golgi membrane, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome lumen, extracellular region, extracellular space, secretory granule lumen, transport vesicle
Pathways: AGE-RAGE pathway, AMPK signaling pathway - Homo sapiens (human), ATF-2 transcription factor network, Adipogenesis, Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Arf6 trafficking events, Autophagy - animal - Homo sapiens (human), Cardiac Progenitor Differentiation, Cori Cycle, Diabetic cardiomyopathy - Homo sapiens (human), Differentiation Pathway, FOXA1 transcription factor network, FOXA2 and FOXA3 transcription factor networks, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Folate Metabolism, FoxO signaling pathway - Homo sapiens (human), Galanin receptor pathway, Glibenclamide Action Pathway, Gliclazide Action Pathway, Glucose Homeostasis, HIF-1 signaling pathway - Homo sapiens (human), Insulin Pathway, Insulin Signalling, Insulin resistance - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Insulin-mediated glucose transport, Leptin Insulin Overlap, Leucine Stimulation on Insulin Signaling, Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MAPK signaling pathway - Homo sapiens (human), Maturity onset diabetes of the young - Homo sapiens (human), Nateglinide Action Pathway, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oocyte meiosis - Homo sapiens (human), Ovarian steroidogenesis - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pancreas Function, Phospholipase D signaling pathway - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of lipolysis in adipocytes - Homo sapiens (human), Repaglinide Action Pathway, Selenium Micronutrient Network, Senescence and Autophagy in Cancer, Signaling events mediated by PTP1B, Signaling events mediated by TCPTP, Type I diabetes mellitus - Homo sapiens (human), Type II diabetes mellitus - Homo sapiens (human), Vitamin B12 metabolism, White fat cell differentiation, cGMP-PKG signaling pathway - Homo sapiens (human), growth hormone signaling pathway, insulin signaling pathway, mTOR signaling pathway - Homo sapiens (human)
UniProt: P01308
Entrez ID: 3630
|
Does Knockout of ABCF1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ABCF1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ABCF1 (ATP binding cassette subfamily F member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: inflammatory response, positive regulation of translation, ribosome biogenesis, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, nucleotide binding, protein binding, ribosome binding, translation activator activity, translation factor activity, RNA binding; CC: cytoplasm, cytosol, membrane, nuclear envelope, nucleoplasm, nucleus
Pathways: ABC-family proteins mediated transport, IL-18 signaling pathway, Transport of small molecules
UniProt: Q8NE71
Entrez ID: 23
|
Does Knockout of MAPK11 in Lymphoma Cell Line causally result in cell proliferation?
| 0
| 646
|
Knockout
|
MAPK11
|
cell proliferation
|
Lymphoma Cell Line
|
Gene: MAPK11 (mitogen-activated protein kinase 11)
Type: protein-coding
Summary: This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: MAPK cascade, NLRP1 inflammasome complex assembly, bone development, cardiac muscle cell proliferation, cellular response to UV-B, cellular response to interleukin-1, cellular response to virus, cellular senescence, intracellular signal transduction, negative regulation of cardiac muscle cell proliferation, osteoblast differentiation, p38MAPK cascade, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of interleukin-12 production, positive regulation of muscle cell differentiation, protein maturation, pyroptotic inflammatory response, regulation of cardiac muscle cell proliferation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade; MF: ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ATF-2 transcription factor network, Activation of PPARGC1A (PGC-1alpha) by phosphorylation, Activation of the AP-1 family of transcription factors, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), CD40/CD40L signaling, CXCR3-mediated signaling events, Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Chagas disease - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Developmental Biology, Diabetic cardiomyopathy - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), ERK/MAPK targets, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), FAS (CD95) signaling pathway, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Fc epsilon RI signaling pathway - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), G1/S DNA Damage Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, Glucocorticoid receptor regulatory network, GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Host-pathogen interaction of human coronaviruses - MAPK signaling, Host-pathogen interaction of human coronaviruses - apoptosis, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL-17 signaling pathway - Homo sapiens (human), IL-4 signaling pathway, IL2-mediated signaling events, IL4, IL6-mediated signaling events, Immune System, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Innate Immune System, Insulin Signaling, Interleukin-17 signaling, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, KSRP (KHSRP) binds and destabilizes mRNA, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAP kinase activation, MAP3K1 role in promoting and blocking gonadal determination, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MAPK targets/ Nuclear events mediated by MAP kinases, Mammalian disorder of sexual development, Metabolism of RNA, Mitochondrial biogenesis, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myogenesis, NOD-like receptor signaling pathway - Homo sapiens (human), NOD1/2 Signaling Pathway, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Novel intracellular components of RIG-I-like receptor (RLR) pathway, Nuclear Events (kinase and transcription factor activation), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, Osteoblast differentiation, Osteoclast differentiation - Homo sapiens (human), Oxidative Stress Induced Senescence, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Parkinson,s disease pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, Physiological and pathological hypertrophy of the heart, Plasma membrane estrogen receptor signaling, Platelet activation - Homo sapiens (human), Prion disease - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Prolactin signaling pathway - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RIG-I-like receptor signaling pathway - Homo sapiens (human), RNA Polymerase II Transcription, Rap1 signaling pathway - Homo sapiens (human), Rapid glucocorticoid signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of p38-alpha and p38-beta, Regulation of retinoblastoma protein, Regulation of toll-like receptor signaling pathway, Regulatory circuits of the STAT3 signaling pathway, Relaxin signaling pathway - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling events mediated by VEGFR1 and VEGFR2, Signaling mediated by p38-alpha and p38-beta, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Signalling to ERKs, Signalling to RAS, Sphingolipid signaling pathway - Homo sapiens (human), Structural Pathway of Interleukin 1 (IL-1), T cell receptor signaling pathway - Homo sapiens (human), TCR, TNF signaling pathway - Homo sapiens (human), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Thermogenesis, Thermogenesis - Homo sapiens (human), Thromboxane A2 receptor signaling, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Transcriptional Regulation by TP53, Tuberculosis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Pathway, VEGFR3 signaling in lymphatic endothelium, Yersinia infection - Homo sapiens (human), activated TAK1 mediates p38 MAPK activation, mapkinase signaling pathway, nfkb activation by nontypeable hemophilus influenzae, p38 MAPK signaling pathway, p38 signaling mediated by MAPKAP kinases, p38MAPK events, p53-Independent G1/S DNA Damage Checkpoint, p73 transcription factor network
UniProt: Q15759
Entrez ID: 5600
|
Does Knockout of OR2A12 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
OR2A12
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: OR2A12 (olfactory receptor family 2 subfamily A member 12)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGT7
Entrez ID: 346525
|
Does Knockout of RNF4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RNF4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RNF4 (ring finger protein 4)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, negative regulation of protein localization to chromatin, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein ubiquitination, regulation of kinetochore assembly, regulation of spindle assembly, response to arsenic-containing substance; MF: DNA binding, SUMO polymer binding, identical protein binding, metal ion binding, nucleosome binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, microtubule end, nuclear body, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Androgen receptor signaling pathway, AndrogenReceptor, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Processing of DNA double-strand break ends
UniProt: P78317
Entrez ID: 6047
|
Does Knockout of PRSS38 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PRSS38
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PRSS38 (serine protease 38)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways:
UniProt: A1L453
Entrez ID: 339501
|
Does Knockout of TRPM7 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TRPM7
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TRPM7 (transient receptor potential cation channel subfamily M member 7)
Type: protein-coding
Summary: This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: actomyosin structure organization, calcium ion transmembrane transport, calcium ion transport, calcium-dependent cell-matrix adhesion, intracellular magnesium ion homeostasis, magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, necroptotic process, programmed cell death, protein autophosphorylation, protein homotetramerization, protein phosphorylation, protein tetramerization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: ATP binding, actin binding, calcium channel activity, kinase activity, magnesium ion transmembrane transporter activity, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, myosin binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, zinc ion transmembrane transporter activity; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, nucleus, plasma membrane, ruffle
Pathways: Cellular senescence - Homo sapiens (human), IL-18 signaling pathway, Ion channel transport, Mineral absorption - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Necroptosis - Homo sapiens (human), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q96QT4
Entrez ID: 54822
|
Does Knockout of DPP6 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
DPP6
|
response to virus
|
Lung Cancer Cell Line
|
Gene: DPP6 (dipeptidyl peptidase like 6)
Type: protein-coding
Summary: This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: protein localization to plasma membrane, proteolysis, regulation of potassium ion transmembrane transport; MF: dipeptidyl-peptidase activity, potassium channel regulator activity, protein binding, serine-type peptidase activity; CC: membrane, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: P42658
Entrez ID: 1804
|
Does Knockout of TOMM40 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
TOMM40
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TOMM40 (translocase of outer mitochondrial membrane 40)
Type: protein-coding
Summary: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: monoatomic ion transport, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane, protein targeting to mitochondrion, protein transport, transmembrane transport; MF: porin activity, protein binding, protein transmembrane transporter activity; CC: TOM complex, cytosol, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, pore complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Autophagy, IL-18 signaling pathway, Macroautophagy, Mitochondrial protein import, Mitophagy, PINK1-PRKN Mediated Mitophagy, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Protein localization, Selective autophagy
UniProt: O96008
Entrez ID: 10452
|
Does Knockout of ZNF821 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ZNF821
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ZNF821 (zinc finger protein 821)
Type: protein-coding
Summary: This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: O75541
Entrez ID: 55565
|
Does Knockout of ZNF665 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
ZNF665
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZNF665 (zinc finger protein 665)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: microtubule cytoskeleton, nucleolus, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9H7R5
Entrez ID: 79788
|
Does Knockout of KIN in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
KIN
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: KIN (Kin17 DNA and RNA binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, mRNA processing; MF: DNA binding, RNA binding, double-stranded DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: O60870
Entrez ID: 22944
|
Does Knockout of TOP2A in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
TOP2A
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TOP2A (DNA topoisomerase II alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA topological change, apoptotic chromosome condensation, chromatin organization, chromosome condensation, chromosome segregation, embryonic cleavage, female meiotic nuclear division, hematopoietic progenitor cell differentiation, positive regulation of apoptotic process, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of transcription by RNA polymerase II, regulation of circadian rhythm, resolution of meiotic recombination intermediates, rhythmic process, sister chromatid segregation; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, RNA binding, chromatin binding, isomerase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase C binding, ubiquitin binding; CC: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, centriole, chromosome, centromeric region, condensed chromosome, cytoplasm, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Etoposide Action Pathway, Etoposide Metabolism Pathway, G0 and Early G1, Gastric Cancer Network 1, Gastric Cancer Network 2, Metabolism of proteins, Mitotic G1 phase and G1/S transition, Post-translational protein modification, Retinoblastoma gene in cancer, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Teniposide Action Pathway, Teniposide Metabolism Pathway, Transcription of E2F targets under negative control by DREAM complex, Validated transcriptional targets of deltaNp63 isoforms
UniProt: P11388
Entrez ID: 7153
|
Does Knockout of ERCC2 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
ERCC2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit)
Type: protein-coding
Summary: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, UV protection, apoptotic process, bone mineralization, central nervous system myelin formation, chromosome segregation, determination of adult lifespan, embryonic cleavage, embryonic organ development, erythrocyte maturation, extracellular matrix organization, hair cell differentiation, hair cycle process, hair follicle maturation, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, in utero embryonic development, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), multicellular organism growth, nucleobase-containing compound metabolic process, nucleotide-excision repair, positive regulation of mitotic recombination, post-embryonic development, regulation of mitotic cell cycle phase transition, regulation of transcription by RNA polymerase II, response to UV, response to hypoxia, response to oxidative stress, ribosomal small subunit biogenesis, skin development, spinal cord development, transcription by RNA polymerase II, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase II promoter, transcription-coupled nucleotide-excision repair; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, damaged DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, protein-macromolecule adaptor activity; CC: CAK-ERCC2 complex, MMXD complex, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, spindle, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), Cytosolic iron-sulfur cluster assembly, DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Fluoropyrimidine Activity, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Male infertility, Metabolism, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide Excision Repair , Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, mRNA Capping
UniProt: P18074
Entrez ID: 2068
|
Does Knockout of RAB4B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
RAB4B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: RAB4B (RAB4B, member RAS oncogene family)
Type: protein-coding
Summary: RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]
Gene Ontology: BP: D-glucose import, Rab protein signal transduction, early endosome to Golgi transport, endosomal vesicle fusion, protein transport, regulation of endocytosis, vesicle-mediated transport; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: cytoplasmic vesicle membrane, cytosol, early endosome membrane, endosome, insulin-responsive compartment, membrane, perinuclear region of cytoplasm, plasma membrane, recycling endosome, secretory granule membrane
Pathways: Immune System, Innate Immune System, Intracellular trafficking proteins involved in CMT neuropathy, MET receptor recycling, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB geranylgeranylation, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: P61018
Entrez ID: 53916
|
Does Knockout of PCBD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
PCBD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1)
Type: protein-coding
Summary: This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: positive regulation of DNA-templated transcription, tetrahydrobiopterin biosynthetic process, tyrosine biosynthetic process, by oxidation of phenylalanine; MF: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity, identical protein binding, lyase activity, phenylalanine 4-monooxygenase activity, protein binding, transcription coactivator activity; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus
Pathways: Folate biosynthesis - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Phenylalanine and tyrosine metabolism, Phenylalanine metabolism, phenylalanine degradation/tyrosine biosynthesis
UniProt: P61457
Entrez ID: 5092
|
Does Knockout of TOP3A in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
TOP3A
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: TOP3A (DNA topoisomerase III alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA recombination, DNA repair, DNA topological change, chromosome separation, double-strand break repair via homologous recombination, meiotic cell cycle, mitochondrial DNA metabolic process, resolution of DNA recombination intermediates; MF: DNA binding, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, isomerase activity, metal ion binding, protein binding, single-stranded DNA binding, zinc ion binding; CC: PML body, RecQ family helicase-topoisomerase III complex, chromosome, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: ATM pathway, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Meiosis, Meiotic recombination, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Strand-asynchronous mitochondrial DNA replication, Transcriptional Regulation by TP53
UniProt: Q13472
Entrez ID: 7156
|
Does Knockout of DDA1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
DDA1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: DDA1 (DET1 and DDB1 associated 1)
Type: protein-coding
Summary: Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteasomal ubiquitin-dependent protein catabolic process; CC: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9BW61
Entrez ID: 79016
|
Does Knockout of VCP in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
VCP
|
cell proliferation
|
Bladder Carcinoma
|
Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: ATP metabolic process, DNA damage response, DNA repair, ERAD pathway, NAD+ metabolic process, aggresome assembly, autophagosome maturation, autophagy, canonical NF-kappaB signal transduction, cellular response to arsenite ion, cellular response to heat, cellular response to misfolded protein, cytoplasm protein quality control, double-strand break repair, endoplasmic reticulum stress-induced pre-emptive quality control, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum unfolded protein response, endosome to lysosome transport via multivesicular body sorting pathway, establishment of protein localization, flavin adenine dinucleotide catabolic process, interstrand cross-link repair, macroautophagy, mitotic spindle disassembly, negative regulation of hippo signaling, negative regulation of protein localization to chromatin, negative regulation of smoothened signaling pathway, positive regulation of ATP biosynthetic process, positive regulation of canonical Wnt signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of oxidative phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, positive regulation of protein catabolic process, positive regulation of protein-containing complex assembly, positive regulation of ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-DNA covalent cross-linking repair, regulation of aerobic respiration, regulation of apoptotic process, regulation of protein localization to chromatin, regulation of synapse organization, retrograde protein transport, ER to cytosol, stress granule disassembly, translesion synthesis, ubiquitin-dependent protein catabolic process, viral genome replication; MF: ADP binding, ATP binding, ATP hydrolysis activity, BAT3 complex binding, K48-linked polyubiquitin modification-dependent protein binding, MHC class I protein binding, RNA binding, deubiquitinase activator activity, hydrolase activity, identical protein binding, lipid binding, nucleotide binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein phosphatase binding, protein-containing complex binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding, ubiquitin-modified protein reader activity, ubiquitin-specific protease binding; CC: ATPase complex, Derlin-1 retrotranslocation complex, VCP-NPL4-UFD1 AAA ATPase complex, VCP-NSFL1C complex, azurophil granule lumen, ciliary basal body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, glutamatergic synapse, intracellular membrane-bounded organelle, lipid droplet, nucleoplasm, nucleus, perinuclear region of cytoplasm, proteasome complex, protein-containing complex, secretory granule lumen, site of double-strand break, synapse
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Aggrephagy, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Attachment and Entry, Autophagy, Cellular response to chemical stress, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Co-inhibition by PD-1, DNA Damage Bypass, DNA Repair, Defective CFTR causes cystic fibrosis, Deubiquitination, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, E3 ubiquitin ligases ubiquitinate target proteins, Early SARS-CoV-2 Infection Events, HSF1 activation, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Infectious disease, Innate Immune System, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Legionellosis - Homo sapiens (human), Macroautophagy, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Neddylation, Neutrophil degranulation, Ovarian tumor domain proteases, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein methylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, RHO GTPase cycle, RHOH GTPase cycle, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Selective autophagy, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, Viral Infection Pathways
UniProt: P55072
Entrez ID: 7415
|
Does Knockout of NPR3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
NPR3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NPR3 (natriuretic peptide receptor 3)
Type: protein-coding
Summary: This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, angiogenesis, blood vessel remodeling, cGMP biosynthetic process, negative regulation of cold-induced thermogenesis, osteoclast proliferation, positive regulation of relaxation of smooth muscle, positive regulation of urine volume, regulation of blood pressure, regulation of osteoblast proliferation, response to ischemia, signal transduction, skeletal system development; MF: G protein-coupled peptide receptor activity, chloride ion binding, hormone binding, natriuretic peptide receptor activity, peptide binding, peptide hormone binding, protein binding, protein homodimerization activity, receptor decoy activity; CC: extracellular exosome, membrane, plasma membrane, protein-containing complex
Pathways:
UniProt: P17342
Entrez ID: 4883
|
Does Knockout of CYP2R1 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
CYP2R1
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: CYP2R1 (cytochrome P450 family 2 subfamily R member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcitriol biosynthetic process from calciol, lipid metabolic process, organic acid metabolic process, response to cesium ion, response to ionizing radiation, response to metal ion, vitamin D biosynthetic process, vitamin D metabolic process, vitamin metabolic process, xenobiotic metabolic process; MF: D3 vitamins binding, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, protein homodimerization activity, vitamin D3 25-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP27B1 causes VDDR1B, Disease, Diseases of metabolism, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of lipids, Metabolism of steroids, Metapathway biotransformation Phase I and II, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Steroid biosynthesis - Homo sapiens (human), Vitamin D (calciferol) metabolism, Vitamin D Metabolism, Vitamins, bile acid biosynthesis, neutral pathway
UniProt: Q6VVX0
Entrez ID: 120227
|
Does Knockout of TOMM40 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
TOMM40
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: TOMM40 (translocase of outer mitochondrial membrane 40)
Type: protein-coding
Summary: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: monoatomic ion transport, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane, protein targeting to mitochondrion, protein transport, transmembrane transport; MF: porin activity, protein binding, protein transmembrane transporter activity; CC: TOM complex, cytosol, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, pore complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Autophagy, IL-18 signaling pathway, Macroautophagy, Mitochondrial protein import, Mitophagy, PINK1-PRKN Mediated Mitophagy, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Protein localization, Selective autophagy
UniProt: O96008
Entrez ID: 10452
|
Does Knockout of MICOS10 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
MICOS10
|
response to virus
|
Hepatoma Cell Line
|
Gene: MICOS10 (mitochondrial contact site and cristae organizing system subunit 10)
Type: protein-coding
Summary: Predicted to be involved in inner mitochondrial membrane organization. Located in mitochondrion. Part of MIB complex; MICOS complex; and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization; CC: MIB complex, MICOS complex, SAM complex, membrane, mitochondrial crista junction, mitochondrial inner membrane, mitochondrion
Pathways: Cristae formation, Mitochondrial biogenesis, Organelle biogenesis and maintenance
UniProt: Q5TGZ0
Entrez ID: 440574
|
Does Knockout of KRT38 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
KRT38
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: KRT38 (keratin 38)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, cytosol, extracellular exosome, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Homo sapiens (human), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Homo sapiens (human), Vitamin D Receptor Pathway
UniProt: O76015
Entrez ID: 8687
|
Does Knockout of RAB35 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
RAB35
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: RAB35 (RAB35, member RAS oncogene family)
Type: protein-coding
Summary: Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, cellular response to nerve growth factor stimulus, endocytic recycling, endosomal transport, intracellular protein localization, mitotic cytokinesis, neuron projection development, plasma membrane to endosome transport, protein localization to endosome, protein transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: cell projection membrane, clathrin-coated endocytic vesicle, clathrin-coated endocytic vesicle membrane, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, cytosol, endosome, endosome membrane, extracellular exosome, intercellular bridge, melanosome, membrane, plasma membrane, recycling endosome membrane
Pathways: Endocytosis - Homo sapiens (human), Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q15286
Entrez ID: 11021
|
Does Knockout of IRF2BPL in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
IRF2BPL
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: IRF2BPL (interferon regulatory factor 2 binding protein like)
Type: protein-coding
Summary: This gene encodes a transcription factor that may play a role in regulating female reproductive function. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: development of secondary female sexual characteristics, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of transcription by RNA polymerase II, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: extracellular space, nucleoplasm, nucleus
Pathways:
UniProt: Q9H1B7
Entrez ID: 64207
|
Does Knockout of CRIM1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CRIM1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CRIM1 (cysteine rich transmembrane BMP regulator 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: insulin-like growth factor receptor signaling pathway, negative regulation of BMP signaling pathway, negative regulation of osteoblast differentiation, nervous system development; MF: PDZ domain binding, enzyme inhibitor activity, insulin-like growth factor receptor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, membrane, plasma membrane
Pathways: EGFR1
UniProt: Q9NZV1
Entrez ID: 51232
|
Does Knockout of ENDOV in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
ENDOV
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ENDOV (endonuclease V)
Type: protein-coding
Summary: Enables DNA binding activity; endoribonuclease activity, producing 5'-phosphomonoesters; and single-stranded RNA binding activity. Predicted to be involved in DNA repair. Located in cytoplasmic stress granule and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA endonuclease activity, producing 5'-phosphomonoesters, RNA binding, RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism, endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, magnesium ion binding, metal ion binding, nuclease activity, protein binding, single-stranded RNA binding; CC: cytoplasm, cytoplasmic stress granule, nucleolus, nucleus
Pathways:
UniProt: Q8N8Q3
Entrez ID: 284131
|
Does Knockout of DDX21 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
DDX21
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: DDX21 (DExD-box helicase 21)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, chromatin remodeling, defense response to virus, immune system process, innate immune response, negative regulation of transcription by RNA polymerase I, osteoblast differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid dendritic cell cytokine production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, rRNA processing, regulation of gene expression, response to exogenous dsRNA, response to virus, transcription by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA polymerase inhibitor activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, miRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding, snoRNA binding; CC: B-WICH complex, chromosome, cytoplasm, cytosol, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Positive epigenetic regulation of rRNA expression, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NR30
Entrez ID: 9188
|
Does Knockout of LTV1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
LTV1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: LTV1 (LTV1 ribosome biogenesis factor)
Type: protein-coding
Summary: Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, ribosome biogenesis; CC: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96GA3
Entrez ID: 84946
|
Does Knockout of COA3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
COA3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: COA3 (cytochrome c oxidase assembly factor 3)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, positive regulation of mitochondrial translation; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Mitochondrial CIV Assembly, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q9Y2R0
Entrez ID: 28958
|
Does Knockout of ERI2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
ERI2
|
cell proliferation
|
Cancer Cell Line
|
Gene: ERI2 (ERI1 exoribonuclease family member 2)
Type: protein-coding
Summary: Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: 3'-5'-RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, zinc ion binding
Pathways:
UniProt: A8K979
Entrez ID: 112479
|
Does Knockout of SRP54 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
SRP54
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SRP54 (signal recognition particle 54)
Type: protein-coding
Summary: Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, SRP-dependent cotranslational protein targeting to membrane, translocation, exocrine pancreas development, granulocyte differentiation, neutrophil chemotaxis, protein targeting to ER; MF: 7S RNA binding, GDP binding, GTP binding, GTPase activity, RNA binding, endoplasmic reticulum signal peptide binding, hydrolase activity, nucleotide binding, protein binding, ribonucleoprotein complex binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nuclear speck, nucleolus, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation, VEGFA-VEGFR2 Signaling Pathway, mRNA Processing
UniProt: P61011
Entrez ID: 6729
|
Does Knockout of EXOSC4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
EXOSC4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: EXOSC4 (exosome component 4)
Type: protein-coding
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nucleic acid metabolic process and positive regulation of cell growth. Acts upstream of or within defense response to virus. Located in cytosol; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA deamination, RNA catabolic process, RNA processing, U4 snRNA 3'-end processing, defense response to virus, histone mRNA catabolic process, maturation of 5.8S rRNA, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of cell growth, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, mRNA 3'-UTR AU-rich region binding, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exoribonuclease complex, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NPD3
Entrez ID: 54512
|
Does Activation of RP2 in T cell causally result in protein/peptide accumulation?
| 1
| 2,426
|
Activation
|
RP2
|
protein/peptide accumulation
|
T cell
|
Gene: RP2 (RP2 activator of ARL3 GTPase)
Type: protein-coding
Summary: The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cilium assembly, post-Golgi vesicle-mediated transport, post-chaperonin tubulin folding pathway, protein folding, protein transport, visual perception; MF: GTP binding, GTPase activator activity, magnesium ion binding, nucleotide binding, protein binding, unfolded protein binding; CC: Golgi apparatus, cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, membrane, nuclear body, nucleoplasm, periciliary membrane compartment, plasma membrane
Pathways: Cargo trafficking to the periciliary membrane, Ciliopathies, Cilium Assembly, Joubert Syndrome, Organelle biogenesis and maintenance, Trafficking of myristoylated proteins to the cilium
UniProt: O75695
Entrez ID: 6102
|
Does Knockout of SH2D3C in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
SH2D3C
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: SH2D3C (SH2 domain containing 3C)
Type: protein-coding
Summary: This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: JNK cascade, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, phosphotyrosine residue binding, protein binding; CC: axon, cell projection, cytoplasm, cytosol, membrane, plasma membrane, ruffle membrane
Pathways: TCR
UniProt: Q8N5H7
Entrez ID: 10044
|
Does Knockout of POLRMT in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
POLRMT
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: POLRMT (RNA polymerase mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, mitochondrial DNA replication, mitochondrial transcription, transcription initiation at mitochondrial promoter; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, RNA binding, mitochondrial promoter sequence-specific DNA binding, nucleotidyltransferase activity, protein binding, sequence-specific DNA binding, transferase activity; CC: DNA-directed RNA polymerase complex, mitochondrial DNA-directed RNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex
Pathways: DNA Replication, Gene expression (Transcription), Mitochondrial Gene Expression, Mitochondrial biogenesis, Mitochondrial transcription initiation, Organelle biogenesis and maintenance, Strand-asynchronous mitochondrial DNA replication, Transcription from mitochondrial promoters, Transcriptional activation of mitochondrial biogenesis
UniProt: O00411
Entrez ID: 5442
|
Does Knockout of KANK2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
KANK2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KANK2 (KN motif and ankyrin repeat domains 2)
Type: protein-coding
Summary: This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: apoptotic process, kidney epithelium development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of actin filament polymerization, negative regulation of cell population proliferation, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of programmed cell death, negative regulation of transcription by RNA polymerase II, negative regulation of vitamin D receptor signaling pathway, podocyte cell migration, regulation of Rho protein signal transduction; CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q63ZY3
Entrez ID: 25959
|
Does Knockout of EMC3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
EMC3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: EMC3 (ER membrane protein complex subunit 3)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity, protein binding; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9P0I2
Entrez ID: 55831
|
Does Knockout of USP17L4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
USP17L4
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: USP17L4 (ubiquitin specific peptidase 17 like family member 4)
Type: protein-coding
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of apoptotic process, regulation of protein stability; MF: cysteine-type deubiquitinase activity; CC: cytosol, endoplasmic reticulum, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: A6NCW7
Entrez ID: 645402
|
Does Activation of RABEP1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
RABEP1
|
protein/peptide accumulation
|
T cell
|
Gene: RABEP1 (rabaptin, RAB GTPase binding effector protein 1)
Type: protein-coding
Summary: Enables protein domain specific binding activity and protein homodimerization activity. Involved in vesicle-mediated transport. Located in endocytic vesicle and endosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi to plasma membrane transport, apoptotic process, endocytosis, membrane fusion, protein localization to ciliary membrane, protein transport, regulation of postsynaptic neurotransmitter receptor internalization, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, growth factor activity, protein binding, protein domain specific binding, protein homodimerization activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endocytic vesicle, endosome, glutamatergic synapse, protein-containing complex, recycling endosome
Pathways: Endocytosis - Homo sapiens (human), Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q15276
Entrez ID: 9135
|
Does Knockout of STIM2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
STIM2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: STIM2 (stromal interaction molecule 2)
Type: protein-coding
Summary: This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009].
Gene Ontology: BP: activation of store-operated calcium channel activity, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, monoatomic ion transport, positive regulation of calcium ion transport, store-operated calcium entry; MF: calcium channel regulator activity, calcium ion binding, metal ion binding, protein binding, store-operated calcium channel activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human)
UniProt: Q9P246
Entrez ID: 57620
|
Does Knockout of MOG in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
MOG
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MOG (myelin oligodendrocyte glycoprotein)
Type: protein-coding
Summary: The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell receptor signaling pathway, cell adhesion, central nervous system development, regulation of cytokine production, symbiont entry into host cell; MF: protein binding, signaling receptor binding, virus receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q16653
Entrez ID: 4340
|
Does Knockout of RPL38 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
RPL38
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: RPL38 (ribosomal protein L38)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis, ossification, protein-RNA complex assembly, regulation of translation, sensory perception of sound, skeletal system development, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, eukaryotic 80S initiation complex, focal adhesion, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Mesodermal commitment pathway, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63173
Entrez ID: 6169
|
Does Activation of FKBP14 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
FKBP14
|
protein/peptide accumulation
|
T cell
|
Gene: FKBP14 (FKBP prolyl isomerase 14)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: MF: calcium ion binding, isomerase activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways: Cellular responses to stimuli, Cellular responses to stress, IRE1alpha activates chaperones, Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: Q9NWM8
Entrez ID: 55033
|
Does Knockout of ZNF354C in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
ZNF354C
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ZNF354C (zinc finger protein 354C)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: angiogenesis, negative regulation of macromolecule biosynthetic process, negative regulation of sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of anatomical structure morphogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, membrane, nuclear lumen, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q86Y25
Entrez ID: 30832
|
Does Knockout of C6orf52 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
C6orf52
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: C6orf52 (chromosome 6 open reading frame 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5T4I8
Entrez ID: 347744
|
Does Knockout of GGTLC2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
GGTLC2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: GGTLC2 (gamma-glutamyltransferase light chain 2)
Type: protein-coding
Summary: This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: glutathione catabolic process, leukotriene D4 biosynthetic process; MF: glutathione hydrolase activity, protein binding
Pathways:
UniProt: Q14390
Entrez ID: 91227
|
Does Knockout of CFDP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
CFDP1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: CFDP1 (craniofacial development protein 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including cell adhesion; negative regulation of fibroblast apoptotic process; and regulation of cell shape. Predicted to be located in kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell adhesion, chromatin remodeling, fibroblast apoptotic process, negative regulation of fibroblast apoptotic process, regulation of cell population proliferation, regulation of cell shape; CC: Swr1 complex, chromosome, chromosome, centromeric region, kinetochore
Pathways:
UniProt: Q9UEE9
Entrez ID: 10428
|
Does Knockout of ZNF442 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ZNF442
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ZNF442 (zinc finger protein 442)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9H7R0
Entrez ID: 79973
|
Does Knockout of NEURL1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
NEURL1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NEURL1 (neuralized E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, cellular response to amino acid stimulus, flagellated sperm motility, lactation, negative regulation of Notch signaling pathway, negative regulation of cell population proliferation, nervous system development, positive regulation of apoptotic process, positive regulation of dendritic spine development, positive regulation of filopodium assembly, positive regulation of long-term neuronal synaptic plasticity, positive regulation of synapse maturation, protein monoubiquitination, protein ubiquitination, regulation of cell communication, regulation of postsynapse assembly, regulation of signaling, regulation of translation, skeletal muscle tissue development, sperm axoneme assembly; MF: metal ion binding, protein binding, transferase activity, translation regulator activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: apical dendrite, cell projection, cytoplasm, dendrite, dendritic spine, glutamatergic synapse, membrane, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, synapse
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, Diseases of signal transduction by growth factor receptors and second messengers, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Notch signaling pathway, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3
UniProt: O76050
Entrez ID: 9148
|
Does Knockout of POU2F1 in Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 674
|
Knockout
|
POU2F1
|
cell proliferation
|
Lung Cancer Cell Line
|
Gene: POU2F1 (POU class 2 homeobox 1)
Type: protein-coding
Summary: The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010].
Gene Ontology: BP: negative regulation of DNA-templated transcription, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, endoplasmic reticulum, nucleoplasm, nucleus
Pathways: ATF-2 transcription factor network, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Calcium signaling in the CD4+ TCR pathway, FOXA1 transcription factor network, Glucocorticoid receptor regulatory network, Herpes simplex virus 1 infection - Homo sapiens (human), Integrated Cancer Pathway, Lipid and atherosclerosis - Homo sapiens (human), Regulation of Androgen receptor activity
UniProt: P14859
Entrez ID: 5451
|
Does Knockout of PRELID1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
PRELID1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: PRELID1 (PRELI domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: apoptotic process, intermembrane lipid transfer, lipid transport, negative regulation of apoptotic process, negative regulation of mitochondrial membrane potential, negative regulation of release of cytochrome c from mitochondria, phospholipid transport, positive regulation of T cell apoptotic process, positive regulation of cellular respiration, positive regulation of endopeptidase activity, positive regulation of phospholipid transport, regulation of T cell differentiation, regulation of membrane lipid distribution, regulation of mitochondrial membrane potential; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Mitochondrial protein degradation, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: Q9Y255
Entrez ID: 27166
|
Does Knockout of POU4F1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
POU4F1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: POU4F1 (POU class 4 homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: axonogenesis, cell migration in hindbrain, cellular response to cytokine stimulus, cellular response to estradiol stimulus, central nervous system neuron differentiation, habenula development, heart development, innervation, intrinsic apoptotic signaling pathway by p53 class mediator, mesoderm development, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of neuron apoptotic process, negative regulation of programmed cell death, negative regulation of transcription by RNA polymerase II, nervous system development, neuron apoptotic process, neuron differentiation, neuron fate specification, neuron migration, neuron projection development, peripheral nervous system neuron development, peripheral nervous system neuron differentiation, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription regulatory region DNA binding, proprioception involved in equilibrioception, regulation of DNA-binding transcription factor activity, regulation of DNA-templated transcription, regulation of cell cycle, regulation of neurogenesis, regulation of transcription by RNA polymerase II, sensory system development, suckling behavior, synapse assembly, trigeminal nerve development, ventricular compact myocardium morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, single-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, neuron projection, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, MECP2 and Associated Rett Syndrome, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Association with Co-factors, Transcriptional Regulation by TP53, Validated nuclear estrogen receptor alpha network
UniProt: Q01851
Entrez ID: 5457
|
Does Knockout of ADSL in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
ADSL
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ADSL (adenylosuccinate lyase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, AMP biosynthetic process, AMP salvage, GMP biosynthetic process, aerobic respiration, purine nucleotide biosynthetic process, purine ribonucleotide biosynthetic process, response to hypoxia, response to muscle activity, response to nutrient, response to starvation; MF: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, catalytic activity, identical protein binding, lyase activity; CC: cytosol, protein-containing complex
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Aspartate Metabolism, Azathioprine Action Pathway, Canavan Disease, Gout or Kelley-Seegmiller Syndrome, Hypoacetylaspartia, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, Nucleotide metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine ribonucleotides <i>de novo</i> biosynthesis, inosine-5,-phosphate biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P30566
Entrez ID: 158
|
Does Knockout of CDK1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
CDK1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CDK1 (cyclin dependent kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, DNA synthesis involved in mitotic DNA replication, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Golgi disassembly, apoptotic process, cell division, cell migration, cellular response to hydrogen peroxide, centrosome cycle, chromatin remodeling, chromosome condensation, cilium disassembly, epithelial cell differentiation, fibroblast proliferation, microtubule cytoskeleton organization, microtubule cytoskeleton organization involved in mitosis, microtubule polymerization, mitotic DNA-templated DNA replication, mitotic G2 DNA damage checkpoint signaling, mitotic cell cycle phase transition, mitotic nuclear membrane disassembly, negative regulation of apoptotic process, negative regulation of gene expression, nuclear envelope organization, peptidyl-threonine phosphorylation, positive regulation of DNA replication, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cardiac muscle cell proliferation, positive regulation of gene expression, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of mitotic sister chromatid segregation, positive regulation of protein import into nucleus, positive regulation of protein localization to nucleus, pronuclear fusion, protein deubiquitination, protein localization to kinetochore, protein localization to site of double-strand break, protein-containing complex assembly, regulation of Schwann cell differentiation, regulation of attachment of mitotic spindle microtubules to kinetochore, regulation of circadian rhythm, regulation of embryonic development, regulation of transcription by RNA polymerase II, response to activity, response to amine, response to axon injury, response to cadmium ion, response to copper ion, response to ethanol, response to hydrogen peroxide, response to toxic substance, rhythmic process, symbiont entry into host cell, thymidine biosynthetic process, ventricular cardiac muscle cell development; MF: ATP binding, Hsp70 protein binding, RNA polymerase II CTD heptapeptide repeat kinase activity, chromatin binding, cyclin binding, cyclin-dependent protein kinase activity, cyclin-dependent protein serine/threonine kinase activity, histone kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, virus receptor activity; CC: centrosome, chromosome, telomeric region, cyclin A1-CDK1 complex, cyclin A2-CDK1 complex, cyclin B1-CDK1 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, membrane, midbody, mitochondrial matrix, mitochondrion, mitotic spindle, nucleoplasm, nucleus, spindle, spindle microtubule
Pathways: AP-1 transcription factor network, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, ATM Signaling Network in Development and Disease, ATM Signaling Pathway, AURKA Activation by TPX2, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Centrosome maturation, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Cilium Assembly, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Cytokine Signaling in Immune system, DNA damage response, Depolymerization of the Nuclear Lamina, Deubiquitination, E2F mediated regulation of DNA replication, E2F transcription factor network, E2F-enabled inhibition of pre-replication complex formation, EGFR1, FOXM1 transcription factor network, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gap junction - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Golgi Cisternae Pericentriolar Stack Reorganization, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Initiation of Nuclear Envelope (NE) Reformation, Interferon Signaling, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, MAPK6/MAPK4 signaling, MASTL Facilitates Mitotic Progression, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear Receptors Meta-Pathway, Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, Ovarian tumor domain proteases, PKR-mediated signaling, PLK1 signaling events, PPAR-alpha pathway, Phosphorylation of Emi1, Phosphorylation of the APC/C, Post-translational protein modification, Progesterone-mediated oocyte maturation - Homo sapiens (human), RAF-independent MAPK1/3 activation, RNA Polymerase II Transcription, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Microtubule Cytoskeleton, Regulation of PLK1 Activity at G2/M Transition, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, Retinoblastoma gene in cancer, Retinoic acid receptors-mediated signaling, Signal Transduction, Spinal Cord Injury, TCR, TGF-beta Signaling Pathway, TGF_beta_Receptor, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX2, Viral carcinogenesis - Homo sapiens (human), akap95 role in mitosis and chromosome dynamics, cdc25 and chk1 regulatory pathway in response to dna damage, cell cycle: g1/s check point, cell cycle: g2/m checkpoint, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, how progesterone initiates the oocyte maturation, miRNA regulation of DNA damage response, p53 signaling pathway - Homo sapiens (human), p73 transcription factor network, protein kinase a at the centrosome, rb tumor suppressor/checkpoint signaling in response to dna damage, regulation of cell cycle progression by plk3, regulation of splicing through sam68, sonic hedgehog receptor ptc1 regulates cell cycle, stathmin and breast cancer resistance to antimicrotubule agents
UniProt: P06493
Entrez ID: 983
|
Does Knockout of OSGEP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
OSGEP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: OSGEP (O-sialoglycoprotein endopeptidase)
Type: protein-coding
Summary: Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA threonylcarbamoyladenosine modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, metal ion binding, protein binding, tRNA N(6)-L-threonylcarbamoyladenine synthase activity, transferase activity; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9NPF4
Entrez ID: 55644
|
Does Knockout of IPO11 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
IPO11
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: IPO11 (importin 11)
Type: protein-coding
Summary: Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008].
Gene Ontology: BP: intracellular protein transport, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: nuclear import signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways:
UniProt: Q9UI26
Entrez ID: 51194
|
Does Knockout of SPINT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
SPINT1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SPINT1 (serine peptidase inhibitor, Kunitz type 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: branching involved in labyrinthine layer morphogenesis, cellular response to BMP stimulus, embryonic placenta development, epidermis development, epithelium development, extracellular matrix organization, negative regulation of neural precursor cell proliferation, neural tube closure, placenta blood vessel development, positive regulation of glial cell differentiation; MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: cytoplasm, extracellular exosome, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Prostate cancer - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: O43278
Entrez ID: 6692
|
Does Knockout of S100A2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
S100A2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: S100A2 (S100 calcium binding protein A2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endothelial cell migration; MF: calcium ion binding, calcium-dependent protein binding, identical protein binding, metal ion binding, protein binding, transition metal ion binding
Pathways: Direct p53 effectors, Validated transcriptional targets of TAp63 isoforms, Vitamin D Receptor Pathway, p73 transcription factor network
UniProt: P29034
Entrez ID: 6273
|
Does Knockout of CCDC38 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
CCDC38
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CCDC38 (coiled-coil domain containing 38)
Type: protein-coding
Summary: Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acrosome assembly, cell differentiation, chromatin organization, intraciliary anterograde transport, sperm flagellum assembly, spermatogenesis; MF: ubiquitin-modified histone reader activity; CC: cell projection, centrosome, cilium, cytoplasm, cytoskeleton, manchette, motile cilium, perinuclear region of cytoplasm, sperm flagellum, sperm head
Pathways:
UniProt: Q502W7
Entrez ID: 120935
|
Does Knockout of CCNDBP1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
CCNDBP1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CCNDBP1 (cyclin D1 binding protein 1)
Type: protein-coding
Summary: This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009].
Gene Ontology: CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: O95273
Entrez ID: 23582
|
Does Knockout of NDC80 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
NDC80
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NDC80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: G2/MI transition of meiotic cell cycle, attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, centrosome duplication, chromosome organization, chromosome segregation, establishment of mitotic spindle orientation, kinetochore organization, metaphase chromosome alignment, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle assembly involved in female meiosis I, spindle organization; MF: cyclin binding, identical protein binding, kinetochore adaptor activity, microtubule binding, protein binding; CC: Ndc80 complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, kinetochore, membrane, nuclear speck, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O14777
Entrez ID: 10403
|
Does Activation of TRAIP in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
TRAIP
|
response to virus
|
Hepatoma Cell Line
|
Gene: TRAIP (TRAF interacting protein)
Type: protein-coding
Summary: This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, negative regulation of interferon-beta production, negative regulation of tumor necrosis factor-mediated signaling pathway, protein ubiquitination, protein-DNA covalent cross-linking repair, replication fork processing, signal transduction; MF: identical protein binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, site of DNA damage
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9BWF2
Entrez ID: 10293
|
Does Knockout of C8B in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
C8B
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: C8B (complement C8 beta chain)
Type: protein-coding
Summary: This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: complement activation, complement activation, GZMK pathway, complement activation, alternative pathway, complement activation, classical pathway, immune response, immune system process, innate immune response, killing of cells of another organism, positive regulation of immune response; CC: extracellular exosome, extracellular region, extracellular space, extracellular vesicle, membrane, membrane attack complex, other organism cell membrane, plasma membrane, transmembrane transporter complex
Pathways: Allograft Rejection, Amoebiasis - Homo sapiens (human), Complement Activation, Complement and coagulation cascades - Homo sapiens (human), Complement cascade, Coronavirus disease - COVID-19 - Homo sapiens (human), Immune System, Innate Immune System, Prion disease - Homo sapiens (human), Regulation of Complement cascade, Systemic lupus erythematosus - Homo sapiens (human), Terminal pathway of complement, alternative complement pathway, classical complement pathway, lectin induced complement pathway
UniProt: P07358
Entrez ID: 732
|
Does Knockout of ACTR8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ACTR8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ACTR8 (actin related protein 8)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Predicted to be involved in chromatin remodeling; double-strand break repair; and regulation of transcription, DNA-templated. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, chromatin remodeling, double-strand break repair, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA metabolic process, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, telomere maintenance; MF: ATP binding, nucleotide binding, protein binding; CC: Ino80 complex, centrosome, chromosome, nucleoplasm, nucleus
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q9H981
Entrez ID: 93973
|
Does Knockout of TRPM7 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
TRPM7
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: TRPM7 (transient receptor potential cation channel subfamily M member 7)
Type: protein-coding
Summary: This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: actomyosin structure organization, calcium ion transmembrane transport, calcium ion transport, calcium-dependent cell-matrix adhesion, intracellular magnesium ion homeostasis, magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, necroptotic process, programmed cell death, protein autophosphorylation, protein homotetramerization, protein phosphorylation, protein tetramerization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: ATP binding, actin binding, calcium channel activity, kinase activity, magnesium ion transmembrane transporter activity, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, myosin binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, zinc ion transmembrane transporter activity; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, nucleus, plasma membrane, ruffle
Pathways: Cellular senescence - Homo sapiens (human), IL-18 signaling pathway, Ion channel transport, Mineral absorption - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Necroptosis - Homo sapiens (human), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q96QT4
Entrez ID: 54822
|
Does Knockout of MIIP in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
MIIP
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: MIIP (migration and invasion inhibitory protein)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell migration
Pathways:
UniProt: Q5JXC2
Entrez ID: 60672
|
Does Knockout of DCTN6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
DCTN6
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DCTN6 (dynactin subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitotic spindle organization; MF: dynein complex binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule cytoskeleton
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: O00399
Entrez ID: 10671
|
Does Knockout of DTNB in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
DTNB
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DTNB (dystrobrevin beta)
Type: protein-coding
Summary: This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: neuron differentiation, synaptic signaling; MF: metal ion binding, protein binding, zinc ion binding; CC: basal plasma membrane, cell projection, cytoplasm, dendrite, inhibitory synapse, membrane, nucleus, plasma membrane, postsynapse, postsynaptic density, synapse
Pathways:
UniProt: O60941
Entrez ID: 1838
|
Does Knockout of NOXRED1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
NOXRED1
|
cell proliferation
|
Cancer Cell Line
|
Gene: NOXRED1 (NADP dependent oxidoreductase domain containing 1)
Type: protein-coding
Summary: Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-proline biosynthetic process, biological_process; MF: molecular_function, oxidoreductase activity, pyrroline-5-carboxylate reductase activity
Pathways:
UniProt: Q6NXP6
Entrez ID: 122945
|
Does Knockout of CRYBG3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
CRYBG3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CRYBG3 (crystallin beta-gamma domain containing 3)
Type: protein-coding
Summary: Enables protein kinase A binding activity. Predicted to be involved in lens development in camera-type eye and visual perception. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lens development in camera-type eye, visual perception; MF: carbohydrate binding, protein kinase A binding, structural constituent of eye lens
Pathways:
UniProt: Q68DQ2
Entrez ID: 131544
|
Does Knockout of CALCB in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
CALCB
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: CALCB (calcitonin related polypeptide beta)
Type: protein-coding
Summary: Predicted to enable calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, calcitonin family receptor signaling pathway, calcitonin gene-related peptide receptor signaling pathway, intracellular calcium ion homeostasis, regulation of cytosolic calcium ion concentration, signal transduction; MF: calcitonin receptor binding, hormone activity, neuropeptide hormone activity, protein binding, receptor ligand activity; CC: extracellular region, extracellular space
Pathways: Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Homo sapiens (human)
UniProt: P10092
Entrez ID: 797
|
Does Knockout of ATE1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
ATE1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: ATE1 (arginyltransferase 1)
Type: protein-coding
Summary: This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: proteasomal protein catabolic process, protein K27-linked ubiquitination, protein K63-linked ubiquitination, protein arginylation, protein targeting to vacuole involved in autophagy, response to oxidative stress, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: acyltransferase activity, arginyl-tRNA--protein transferase activity, protein binding, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: O95260
Entrez ID: 11101
|
Does Knockout of OR2T1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
OR2T1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR2T1 (olfactory receptor family 2 subfamily T member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, GPCRs, Class A Rhodopsin-like, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: O43869
Entrez ID: 26696
|
Does Knockout of LTBP1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
LTBP1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: LTBP1 (latent transforming growth factor beta binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell surface receptor protein serine/threonine kinase signaling pathway, establishment of protein localization to extracellular region, sequestering of TGFbeta in extracellular matrix; MF: calcium ion binding, extracellular matrix structural constituent, growth factor binding, microfibril binding, molecular adaptor activity, protein binding, receptor ligand inhibitor activity, transforming growth factor beta binding, transforming growth factor beta receptor activity; CC: endoplasmic reticulum lumen, extracellular matrix, extracellular region, microfibril, protein-containing complex
Pathways: Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human)
UniProt: Q14766
Entrez ID: 4052
|
Does Knockout of ISG20L2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
ISG20L2
|
cell proliferation
|
Cancer Cell Line
|
Gene: ISG20L2 (interferon stimulated exonuclease gene 20 like 2)
Type: protein-coding
Summary: This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA metabolic process, RNA processing, ribosome biogenesis; MF: 3'-5'-RNA exonuclease activity, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H9L3
Entrez ID: 81875
|
Does Knockout of FAM218A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
FAM218A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FAM218A (family with sequence similarity 218 member A)
Type: ncRNA
Summary: family with sequence similarity 218 member A
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 152756
|
Does Knockout of CELF1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
CELF1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: CELF1 (CUGBP Elav-like family member 1)
Type: protein-coding
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, embryo development ending in birth or egg hatching, germ cell development, mRNA destabilization, mRNA processing, mRNA splice site recognition, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of translation, positive regulation of gene expression, post-transcriptional gene silencing, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of inflammatory response, regulatory ncRNA-mediated post-transcriptional gene silencing; MF: BRE binding, RNA binding, mRNA 3'-UTR binding, mRNA binding, mRNA regulatory element binding translation repressor activity, nucleic acid binding, pre-mRNA binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, membrane, nucleoplasm, nucleus, perinucleolar compartment, ribonucleoprotein complex
Pathways: Adipogenesis, mRNA Processing
UniProt: Q92879
Entrez ID: 10658
|
Does Knockout of GEMIN7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
GEMIN7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GEMIN7 (gem nuclear organelle associated protein 7)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, Sm-like protein family complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, snRNP Assembly
UniProt: Q9H840
Entrez ID: 79760
|
Does Knockout of SLC7A5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SLC7A5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SLC7A5 (solute carrier family 7 member 5)
Type: protein-coding
Summary: Enables L-leucine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Is integral component of membrane. Part of amino acid transport complex; apical plasma membrane; and microvillus membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, L-amino acid transport, L-histidine transport, L-leucine import across plasma membrane, L-leucine transport, L-tryptophan transmembrane transport, alanine transport, amino acid import across plasma membrane, amino acid transmembrane transport, amino acid transport, cellular response to L-arginine, cellular response to amino acid stimulus, cellular response to glucose starvation, cellular response to lipopolysaccharide, isoleucine transport, liver regeneration, methionine transport, negative regulation of autophagy, negative regulation of gene expression, negative regulation of vascular associated smooth muscle cell apoptotic process, neutral amino acid transport, phenylalanine transport, positive regulation of L-leucine import across plasma membrane, positive regulation of cytokine production involved in immune response, positive regulation of glial cell proliferation, positive regulation of interleukin-17 production, positive regulation of interleukin-4 production, positive regulation of type II interferon production, proline transport, response to hyperoxia, response to muscle activity, thyroid hormone transport, transmembrane transport, transport across blood-brain barrier, tryptophan transport, tyrosine transport, valine transport, xenobiotic transport; MF: L-amino acid transmembrane transporter activity, L-leucine transmembrane transporter activity, L-tryptophan transmembrane transporter activity, amino acid transmembrane transporter activity, antiporter activity, aromatic amino acid transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, peptide antigen binding, protein binding, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: amino acid transport complex, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cytosol, external side of apical plasma membrane, extracellular exosome, lysosomal membrane, lysosome, membrane, microvillus membrane, plasma membrane
Pathways: Amiloride Action Pathway, Amino acid transport across the plasma membrane, Aryl Hydrocarbon Receptor Pathway, Basigin interactions, Bendroflumethiazide Action Pathway, Blue diaper syndrome, Bumetanide Action Pathway, Cell surface interactions at the vascular wall, Central carbon metabolism in cancer - Homo sapiens (human), Chlorothiazide Action Pathway, Chlorthalidone Action Pathway, Cyclothiazide Action Pathway, Cystinuria, Eplerenone Action Pathway, Ethacrynic Acid Action Pathway, Furosemide Action Pathway, Glucose Transporter Defect (SGLT2), Hartnup Disorder, Hemostasis, Hydrochlorothiazide Action Pathway, Hydroflumethiazide Action Pathway, Iminoglycinuria, Indapamide Action Pathway, Kidney Function, Leucine Stimulation on Insulin Signaling, Lysinuric Protein Intolerance, Lysinuric protein intolerance (LPI), Metabolism, Metabolism of amino acids and derivatives, Methyclothiazide Action Pathway, Metolazone Action Pathway, Nuclear Receptors Meta-Pathway, Polythiazide Action Pathway, Quinethazone Action Pathway, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Spironolactone Action Pathway, Torsemide Action Pathway, Transport of small molecules, Triamterene Action Pathway, Trichlormethiazide Action Pathway, Tryptophan catabolism, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q01650
Entrez ID: 8140
|
Does Knockout of MIR3646 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
MIR3646
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: MIR3646 (microRNA 3646)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100500813
|
Does Knockout of EMSY in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
EMSY
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: EMSY (EMSY transcriptional repressor, BRCA2 interacting)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in DNA repair; chromatin organization; and regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, regulation of DNA-templated transcription; MF: identical protein binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Mesodermal commitment pathway
UniProt: Q7Z589
Entrez ID: 56946
|
Does Knockout of USP36 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
USP36
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: USP36 (ubiquitin specific peptidase 36)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of macroautophagy, nucleolus organization, positive regulation of protein targeting to mitochondrion, protein deubiquitination, protein stabilization, proteolysis, regulation of apoptotic process, regulation of mitophagy, regulation of protein stability, regulation of rRNA processing; MF: K48-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, hydrolase activity, peptidase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9P275
Entrez ID: 57602
|
Does Knockout of B3GNT7 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
B3GNT7
|
response to virus
|
Hepatoma Cell Line
|
Gene: B3GNT7 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7)
Type: protein-coding
Summary: Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: keratan sulfate proteoglycan biosynthetic process, poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, UDP-glycosyltransferase activity, acetylglucosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: Q8NFL0
Entrez ID: 93010
|
Does Knockout of AASDHPPT in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
AASDHPPT
|
response to virus
|
Hepatoma Cell Line
|
Gene: AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase)
Type: protein-coding
Summary: The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 10-formyltetrahydrofolate catabolic process, pantothenate metabolic process, protein maturation; MF: holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, metal ion binding, protein binding, transferase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, acyl carrier protein metabolism
UniProt: Q9NRN7
Entrez ID: 60496
|
Does Knockout of PEBP1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
PEBP1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: PEBP1 (phosphatidylethanolamine binding protein 1)
Type: protein-coding
Summary: This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015].
Gene Ontology: MF: ATP binding, RNA binding, enzyme binding, lipid binding, nucleotide binding, peptidase inhibitor activity, phosphatidylethanolamine binding, protein binding, protein kinase binding, serine-type endopeptidase inhibitor activity; CC: cytoplasm, cytosol, extracellular exosome, nucleus
Pathways: Aurora B signaling, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGF-EGFR signaling pathway, EGFR1, ErbB1 downstream signaling, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, Oncogenic MAPK signaling, Pancreatic adenocarcinoma pathway, Paradoxical activation of RAF signaling by kinase inactive BRAF, RAF/MAP kinase cascade, Signal Transduction, Signaling by BRAF and RAF1 fusions, Signaling by RAS mutants, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, signal transduction through il1r
UniProt: P30086
Entrez ID: 5037
|
Does Knockout of UTP20 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
UTP20
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UTP20 (UTP20 small subunit processome component)
Type: protein-coding
Summary: UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of cell population proliferation, rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: 90S preribosome, cytoplasm, nucleolus, nucleoplasm, nucleus, plasma membrane, preribosome, small subunit precursor, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O75691
Entrez ID: 27340
|
Does Knockout of DDX47 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
DDX47
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DDX47 (DEAD-box helicase 47)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H0S4
Entrez ID: 51202
|
Does Knockout of WDR82 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
WDR82
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: WDR82 (WD repeat domain 82)
Type: protein-coding
Summary: TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010].
Gene Ontology: BP: DNA-templated transcription termination, RNA polymerase II promoter clearance, gene expression, lncRNA catabolic process, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance, positive regulation of transcription elongation by RNA polymerase II; MF: chromatin binding, lncRNA binding, protein binding; CC: PTW/PP1 phosphatase complex, Set1C/COMPASS complex, chromatin, chromosome, chromosome, telomeric region, cytoplasm, histone methyltransferase complex, nucleolus, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Metabolism of RNA, Nuclear RNA decay, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q6UXN9
Entrez ID: 80335
|
Does Knockout of ORC5 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
ORC5
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ORC5 (origin recognition complex subunit 5)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: DNA replication, DNA replication initiation, regulation of DNA replication; MF: ATP binding, DNA replication origin binding, nucleotide binding, protein binding; CC: chromatin, chromosome, chromosome, telomeric region, cytosol, nuclear origin of replication recognition complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, E2F mediated regulation of DNA replication, E2F-enabled inhibition of pre-replication complex formation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, cdk regulation of dna replication
UniProt: O43913
Entrez ID: 5001
|
Does Knockout of KCTD21 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
KCTD21
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: KCTD21 (potassium channel tetramerization domain containing 21)
Type: protein-coding
Summary: Enables cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of smoothened signaling pathway, protein homooligomerization, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: cullin family protein binding, histone deacetylase binding, identical protein binding, protein binding
Pathways:
UniProt: Q4G0X4
Entrez ID: 283219
|
Does Knockout of PLAGL2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
PLAGL2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PLAGL2 (PLAG1 like zinc finger 2)
Type: protein-coding
Summary: Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chylomicron assembly, lipid metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q9UPG8
Entrez ID: 5326
|
Does Knockout of RPL31 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
RPL31
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL31 (ribosomal protein L31)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, large ribosomal subunit, membrane, nucleoplasm, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62899
Entrez ID: 6160
|
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