prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ifna5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ifna5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ifna5 (interferon alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q810G2
Entrez ID: 15968
|
Does Knockout of Tab2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,142
|
Knockout
|
Tab2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tab2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2)
Type: protein-coding
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: canonical NF-kappaB signal transduction, defense response to bacterium, heart development, inflammatory response, negative regulation of canonical NF-kappaB signal transduction, non-canonical NF-kappaB signal transduction, p38MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein kinase activity, protein K63-linked ubiquitination, response to lipopolysaccharide; MF: K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, molecular adaptor activity, protein binding, ubiquitin binding, zinc ion binding; CC: cytoplasm, cytosol, endosome, endosome membrane, lysosomal membrane, lysosome, membrane, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Alpha-protein kinase 1 signaling pathway, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Osteoclast differentiation - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TCR signaling, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation
UniProt: Q99K90
Entrez ID: 68652
|
Does Knockout of Cfap58 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Cfap58
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cfap58 (cilia and flagella associated protein 58)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, cell projection organization, cilium assembly, flagellated sperm motility, protein localization to motile cilium, sperm axoneme assembly, sperm flagellum assembly, sperm mitochondrial sheath assembly; CC: cell projection, centrosome, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum, sperm midpiece
Pathways:
UniProt: B2RW38
Entrez ID: 381229
|
Does Knockout of Atp6v1c1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Atp6v1c1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Atp6v1c1 (ATPase, H+ transporting, lysosomal V1 subunit C1)
Type: protein-coding
Summary: Enables proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in plasma membrane. Part of proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical part of cell, clathrin-coated vesicle membrane, cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9Z1G3
Entrez ID: 66335
|
Does Knockout of Zfp286 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Zfp286
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp286 (zinc finger protein 286)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8R0E0, Q8C0E6, A0A140LIZ8, Q5SVS7
Entrez ID: 192651
|
Does Knockout of Vps33b in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Vps33b
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Vps33b (vacuolar protein sorting 33B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen fibril organization, collagen metabolic process, endosome organization, intracellular protein transport, lysosome localization, megakaryocyte development, melanosome localization, membrane fusion, platelet alpha granule organization, protein transport, regulation of platelet aggregation, skin morphogenesis, vesicle-mediated transport; MF: protein binding, protein-containing complex binding; CC: CORVET complex, Golgi apparatus, HOPS complex, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, early endosome, early endosome membrane, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, platelet alpha granule, recycling endosome, synaptic vesicle, vesicle tethering complex
Pathways:
UniProt: P59016
Entrez ID: 233405
|
Does Knockout of Sec11c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Sec11c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sec11c (SEC11 homolog C, signal peptidase complex subunit)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; respiratory system; sensory organ; and telencephalon. Orthologous to human SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis, signal peptide processing; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Metabolism of proteins, Peptide hormone metabolism, Protein export - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Synthesis, secretion, and deacylation of Ghrelin
UniProt: Q9D8V7
Entrez ID: 66286
|
Does Knockout of Zfp335 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Zfp335
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Zfp335 (zinc finger protein 335)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, brain morphogenesis, cerebral cortex neuron differentiation, epigenetic regulation of gene expression, in utero embryonic development, neuron projection morphogenesis, positive regulation of cell population proliferation, positive regulation of lymphocyte proliferation, positive regulation of neuroblast proliferation, positive regulation of neurogenesis, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of neurogenesis; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone methyltransferase binding, metal ion binding, protein binding, transcription cis-regulatory region binding, zinc ion binding; CC: histone methyltransferase complex, nucleoplasm, nucleus
Pathways:
UniProt: A2A5K6
Entrez ID: 329559
|
Does Knockout of Asxl2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Asxl2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Asxl2 (ASXL transcriptional regulator 2)
Type: protein-coding
Summary: This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: adult heart development, animal organ morphogenesis, embryonic skeletal system morphogenesis, heart development, heart morphogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of bone mineralization involved in bone maturation, positive regulation of fat cell differentiation, positive regulation of lipid storage, positive regulation of macrophage differentiation, positive regulation of osteoclast differentiation, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, chromatin binding, metal ion binding, peroxisome proliferator activated receptor binding, protein binding, zinc ion binding; CC: PR-DUB complex, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q8BZ32
Entrez ID: 75302
|
Does Knockout of Taf10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Taf10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Taf10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois development, apoptotic process, chromatin remodeling, embryonic placenta development, gene expression, hepatocyte differentiation, in utero embryonic development, lateral mesodermal cell differentiation, limb development, liver development, mRNA transcription by RNA polymerase II, multicellular organism growth, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, protein-containing complex assembly, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of gene expression, regulation of transcription by RNA polymerase II, somitogenesis, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase binding, enzyme binding, histone acetyltransferase activity, identical protein binding, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding; CC: SAGA complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription factor TFIID complex, transcription factor TFTC complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), Deubiquitination, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, Ub-specific processing proteases
UniProt: Q8K0H5
Entrez ID: 24075
|
Does Knockout of Nuggc in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Nuggc
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nuggc (nuclear GTPase, germinal center associated)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Acts upstream of or within DNA damage response and somatic hypermutation of immunoglobulin genes. Located in nucleus. Orthologous to human NUGGC (nuclear GTPase, germinal center associated). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, cellular response to lipopolysaccharide, negative regulation of apoptotic process, regulation of nuclear cell cycle DNA replication, somatic hypermutation of immunoglobulin genes; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: cytosol, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: D3YWJ0
Entrez ID: 100503545
|
Does Knockout of Foxd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Foxd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Foxd1 (forkhead box D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, axon guidance, branching involved in ureteric bud morphogenesis, canonical Wnt signaling pathway, cell differentiation, dichotomous subdivision of terminal units involved in ureteric bud branching, kidney development, luteinizing hormone secretion, metanephric capsule development, metanephric capsule specification, metanephric nephron development, negative regulation of DNA-templated transcription, nephrogenic mesenchyme development, pattern specification involved in metanephros development, positive regulation of BMP signaling pathway, positive regulation of gene expression, positive regulation of kidney development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding
Pathways:
UniProt: Q61345
Entrez ID: 15229
|
Does Knockout of Kel in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Kel
|
cell cycle progression
|
breast epithelium
|
Gene: Kel (Kell blood group)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, intracellular calcium ion homeostasis, intracellular magnesium ion homeostasis, myelination, negative regulation of potassium ion transmembrane transport, protein processing, proteolysis, regulation of axon diameter, regulation of cell size, skeletal muscle fiber development; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: Golgi apparatus, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9EQF2
Entrez ID: 23925
|
Does Knockout of Gba2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gba2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gba2 (glucosidase beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid metabolic process, carbohydrate metabolic process, central nervous system development, central nervous system neuron development, cholesterol metabolic process, glucosylceramide catabolic process, glycolipid biosynthetic process, glycoside catabolic process, lipid metabolic process, regulation of actin filament polymerization, regulation of membrane lipid distribution, regulation of microtubule polymerization, small molecule metabolic process, sphingolipid metabolic process, steroid metabolic process; MF: beta-glucosidase activity, galactosylceramidase activity, glucosylceramidase activity, glucosyltransferase activity, glycosyltransferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, steryl-beta-glucosidase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Other glycan degradation - Mus musculus (mouse), Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse)
UniProt: Q69ZF3
Entrez ID: 230101
|
Does Knockout of Adgrg7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Adgrg7
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Adgrg7 (adhesion G protein-coupled receptor G7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8BM96
Entrez ID: 239853
|
Does Knockout of Haus1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Haus1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Haus1 (HAUS augmin-like complex, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8BHX1
Entrez ID: 225745
|
Does Knockout of Cops6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Cops6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cops6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deneddylation; MF: metallopeptidase activity, peptidase activity, protein binding; CC: COP9 signalosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: O88545
Entrez ID: 26893
|
Does Knockout of Mms22l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Mms22l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mms22l (MMS22-like, DNA repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, double-strand break repair via homologous recombination, protein localization to chromatin, replication fork processing; MF: DNA binding, molecular_function, single-stranded DNA binding; CC: FACT complex, MCM complex, chromosome, cytosol, nuclear replication fork, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways:
UniProt: B1AUR6
Entrez ID: 212377
|
Does Knockout of Qrich1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Qrich1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Qrich1 (glutamine-rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: PERK-mediated unfolded protein response, endoplasmic reticulum unfolded protein response, integrated stress response signaling, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, kidney development, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, response to endoplasmic reticulum stress, response to unfolded protein; MF: DNA binding; CC: cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q3UA37
Entrez ID: 69232
|
Does Knockout of Cycs in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Cycs
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cycs (cytochrome c, somatic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, hydrogen peroxide metabolic process, intrinsic apoptotic signaling pathway, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c; MF: electron transfer activity, enzyme binding, heme binding, metal ion binding; CC: apoptosome, cytosol, mitochondrial intermembrane space, mitochondrion, myelin sheath, nucleus
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P62897
Entrez ID: 13063
|
Does Knockout of Rraga in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Rraga
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rraga (Ras-related GTP binding A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, apoptotic process, autophagosome assembly, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to methionine, cellular response to nutrient levels, cellular response to starvation, cytoplasmic translation, glucose homeostasis, intracellular protein localization, intracellular signal transduction, negative regulation of autophagy, negative regulation of translational initiation, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of translational initiation, protein localization to lysosome, protein localization to membrane, regulation of TORC1 signaling, regulation of cytolysis, response to amino acid, tumor necrosis factor-mediated signaling pathway; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, phosphoprotein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-membrane adaptor activity, ubiquitin protein ligase binding; CC: FNIP-folliculin RagC/D GAP, GATOR1 complex, Gtr1-Gtr2 GTPase complex, cytoplasm, lysosomal membrane, lysosome, membrane, nucleoplasm, nucleus
Pathways: Amino acids regulate mTORC1, Autophagy, Autophagy - animal - Mus musculus (mouse), Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, E3 ubiquitin ligases ubiquitinate target proteins, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, Metabolism of proteins, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q80X95
Entrez ID: 68441
|
Does Knockout of Slamf8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Slamf8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Slamf8 (SLAM family member 8)
Type: protein-coding
Summary: Enables identical protein binding activity and signaling receptor activity. Involved in B-1 B cell lineage commitment and regulation of B cell differentiation. Acts upstream of or within several processes, including leukocyte chemotaxis involved in inflammatory response; negative regulation of leukocyte migration; and negative regulation of respiratory burst involved in inflammatory response. Predicted to be located in membrane. Orthologous to human SLAMF8 (SLAM family member 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B-1 B cell lineage commitment, cellular response to xenobiotic stimulus, defense response to bacterium, immune response, leukocyte chemotaxis involved in inflammatory response, negative regulation of dendritic cell chemotaxis, negative regulation of macrophage chemotaxis, negative regulation of monocyte chemotaxis, negative regulation of neutrophil migration, negative regulation of respiratory burst involved in inflammatory response, phagosome acidification, regulation of B cell differentiation; MF: identical protein binding, signaling receptor activity
Pathways:
UniProt: Q9D3G2
Entrez ID: 74748
|
Does Knockout of Psg26 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Psg26
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Psg26 (pregnancy-specific beta-1-glycoprotein 26)
Type: protein-coding
Summary: Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Orthologous to human CEACAM21 (CEA cell adhesion molecule 21). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T cell activation, female pregnancy, immune response; CC: cellular_component, external side of plasma membrane
Pathways:
UniProt: Q4KL65
Entrez ID: 574429
|
Does Knockout of Ube2c in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ube2c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ube2c (ubiquitin-conjugating enzyme E2C)
Type: protein-coding
Summary: Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin-like protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic cell cycle phase transition; and protein polyubiquitination. Predicted to be located in cytosol and plasma membrane. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; neural retina; and spleen. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell division, exit from mitosis, free ubiquitin chain polymerization, positive regulation of exit from mitosis, positive regulation of mitotic metaphase/anaphase transition, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiquitination, regulation of mitotic metaphase/anaphase transition, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-like protein ligase binding, ubiquitin-protein transferase activity; CC: anaphase-promoting complex, cytosol, nucleus, plasma membrane, ubiquitin ligase complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Phosphorylation of the APC/C, Post-translational protein modification, Protein ubiquitination, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9D1C1
Entrez ID: 68612
|
Does Knockout of Gm815 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gm815
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm815 (predicted gene 815)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A494BAC9, Q3UWS2
Entrez ID: 329047
|
Does Knockout of U2af1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
U2af1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: U2af1 (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, RS domain binding, metal ion binding, nucleic acid binding, pre-mRNA 3'-splice site binding, protein binding, zinc ion binding; CC: U2AF complex, catalytic step 2 spliceosome, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D883
Entrez ID: 108121
|
Does Knockout of Jak2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Jak2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Jak2 (Janus kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, activation of Janus kinase activity, adaptive immune response, apoptotic signaling pathway, axon regeneration, cell adhesion, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to dexamethasone stimulus, cellular response to interleukin-3, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, chromatin organization, chromatin remodeling, collagen-activated signaling pathway, cytokine-mediated signaling pathway, defense response to symbiont, enzyme-linked receptor protein signaling pathway, erythrocyte differentiation, erythropoietin-mediated signaling pathway, extrinsic apoptotic signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, hormone-mediated signaling pathway, immune response, immune system process, innate immune response, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-3-mediated signaling pathway, interleukin-5-mediated signaling pathway, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, lipopolysaccharide-mediated signaling pathway, mammary gland epithelium development, microglial cell activation, modulation of chemical synaptic transmission, myeloid cell differentiation, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of cytokine production involved in inflammatory response, negative regulation of growth hormone receptor signaling pathway, negative regulation of neuron apoptotic process, nuclear receptor-mediated mineralocorticoid signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of MHC class II biosynthetic process, positive regulation of NK T cell proliferation, positive regulation of SMAD protein signal transduction, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell activation, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of growth hormone receptor signaling pathway, positive regulation of insulin secretion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-17 production, positive regulation of intracellular signal transduction, positive regulation of leukocyte proliferation, positive regulation of natural killer cell proliferation, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, positive regulation of platelet aggregation, positive regulation of protein import into nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of vascular associated smooth muscle cell proliferation, post-embryonic hemopoiesis, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autophosphorylation, regulation of T cell activation, regulation of apoptotic process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of nitric oxide biosynthetic process, regulation of postsynapse to nucleus signaling pathway, response to antibiotic, response to granulocyte macrophage colony-stimulating factor, response to hydroperoxide, response to interleukin-12, response to oxidative stress, response to tumor necrosis factor, signal transduction, symbiont-induced defense-related programmed cell death, thrombopoietin-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, SH2 domain binding, acetylcholine receptor binding, cytokine receptor binding, growth hormone receptor binding, heme binding, histone H3Y41 kinase activity, histone binding, identical protein binding, insulin receptor substrate binding, interleukin-12 receptor binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor activator activity, signaling receptor binding, transferase activity, type 1 angiotensin receptor binding; CC: caveola, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endomembrane system, euchromatin, extrinsic component of cytoplasmic side of plasma membrane, extrinsic component of plasma membrane, focal adhesion, glutamatergic synapse, granulocyte macrophage colony-stimulating factor receptor complex, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, membrane raft, nucleoplasm, nucleus, plasma membrane, postsynapse
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cyclin D associated events in G1, Cytokine Signaling in Immune system, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Factors involved in megakaryocyte development and platelet production, G1 Phase, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Interleukin receptor SHC signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-2 family signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Mitotic G1 phase and G1/S transition, Necroptosis - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin receptor signaling, Prolactin signaling pathway - Mus musculus (mouse), RAF activation, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Regulation of IFNG signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Erythropoietin, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q62120
Entrez ID: 16452
|
Does Knockout of 1700020L24Rik in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
1700020L24Rik
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: 1700020L24Rik (RIKEN cDNA 1700020L24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C1R3
Entrez ID: 66330
|
Does Knockout of Nub1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Nub1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nub1 (negative regulator of ubiquitin-like proteins 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of ubiquitin-dependent protein catabolic process, response to tumor necrosis factor, response to type II interferon, ubiquitin-dependent protein catabolic process; CC: Lewy body, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P54729
Entrez ID: 53312
|
Does Knockout of Crocc in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Crocc
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Crocc (ciliary rootlet coiled-coil, rootletin)
Type: protein-coding
Summary: Enables actin binding activity; kinesin binding activity; and structural molecule activity. A structural constituent of cytoskeleton. Acts upstream of or within several processes, including ciliary basal body organization; epithelial structure maintenance; and photoreceptor cell maintenance. Located in several cellular components, including cytoskeleton; photoreceptor inner segment; and subapical part of cell. Is expressed in brain; ciliated columnar oviduct epithelium; metanephros; retina; and trachea. Orthologous to human CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell projection organization, cellular homeostasis, centriole-centriole cohesion, centrosome cycle, ciliary basal body organization, epithelial structure maintenance, establishment of localization in cell, establishment of organelle localization, intracellular protein localization, photoreceptor cell maintenance, positive regulation of cilium assembly, positive regulation of protein localization to cilium; MF: actin binding, kinesin binding, protein binding, structural constituent of cytoskeleton, structural molecule activity; CC: 9+2 motile cilium, actin cytoskeleton, cell projection, centriole, centrosome, ciliary basal body, ciliary rootlet, cilium, cytoplasm, cytoskeleton, cytosol, glial cell projection, photoreceptor inner segment, plasma membrane, subapical part of cell
Pathways:
UniProt: Q8CJ40
Entrez ID: 230872
|
Does Knockout of Steap1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Steap1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Steap1 (six transmembrane epithelial antigen of the prostate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heme binding, metal ion binding; CC: endosome, endosome membrane, membrane, plasma membrane
Pathways: Mineral absorption - Mus musculus (mouse)
UniProt: Q9CWR7
Entrez ID: 70358
|
Does Knockout of Ankrd52 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Ankrd52
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ankrd52 (ankyrin repeat domain 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BTI7
Entrez ID: 237615
|
Does Knockout of Hikeshi in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Hikeshi
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hikeshi (heat shock protein nuclear import factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cellular response to heat, lung development, protein import into nucleus, protein transport; MF: Hsp70 protein binding, nuclear import signal receptor activity; CC: cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q9DD02
Entrez ID: 67669
|
Does Knockout of Cldn34b2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cldn34b2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cldn34b2 (claudin 34B2)
Type: protein-coding
Summary: Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN34 (claudin 34). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: bicellular tight junction assembly, cell adhesion; MF: molecular_function, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane
Pathways:
UniProt: Q9D9N2
Entrez ID: 73347
|
Does Knockout of Tmem88 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tmem88
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem88 (transmembrane protein 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, protein localization to plasma membrane, protein stabilization; MF: PDZ domain binding, protein binding; CC: cytosol, membrane, plasma membrane
Pathways:
UniProt: Q9D0N8
Entrez ID: 67020
|
Does Knockout of Vstm2l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Vstm2l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Vstm2l (V-set and transmembrane domain containing 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of neuron apoptotic process; CC: cytoplasm, extracellular region, membrane
Pathways:
UniProt: Q6PDS0
Entrez ID: 277432
|
Does Knockout of Zfp697 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Zfp697
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zfp697 (zinc finger protein 697)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZNF697 (zinc finger protein 697). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: regulation of transcription by RNA polymerase II, response to type II interferon; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, miRNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q569E7
Entrez ID: 242109
|
Does Knockout of Ttc14 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ttc14
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ttc14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
UniProt: Q9CSP9
Entrez ID: 67120
|
Does Knockout of Arpc1b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Arpc1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arpc1b (actin related protein 2/3 complex, subunit 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation; MF: actin binding, actin filament binding, protein-containing complex binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cytoskeleton, cytoplasm, cytoskeleton, nucleus, tubulobulbar complex
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q9WV32
Entrez ID: 11867
|
Does Knockout of Trim71 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Trim71
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Trim71 (tripartite motif-containing 71)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, G1/S transition of mitotic cell cycle, fibroblast growth factor receptor signaling pathway, miRNA processing, miRNA-mediated gene silencing by inhibition of translation, negative regulation of translation, neural tube closure, neural tube development, positive regulation of miRNA-mediated gene silencing, post-transcriptional regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of miRNA-mediated gene silencing, regulation of neural precursor cell proliferation, regulation of protein metabolic process, regulatory ncRNA-mediated gene silencing, stem cell proliferation; MF: RNA binding, metal ion binding, miRNA binding, protein binding, transferase activity, translation repressor activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, MicroRNAs in cancer - Mus musculus (mouse)
UniProt: Q1PSW8
Entrez ID: 636931
|
Does Knockout of Elavl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Elavl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Elavl1 (ELAV like RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, cell population proliferation, lncRNA-mediated post-transcriptional gene silencing, mRNA destabilization, mRNA stabilization, negative regulation of miRNA-mediated gene silencing, positive regulation of autophagosome size, positive regulation of autophagy, positive regulation of superoxide anion generation, positive regulation of translation, post-transcriptional gene silencing, protein homooligomerization, protein import into nucleus, regulation of mRNA stability, regulation of stem cell population maintenance, response to glucose; MF: RNA binding, double-stranded RNA binding, lncRNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, miRNA binding, nucleic acid binding, protein binding, protein homodimerization activity, protein kinase binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytoplasmic vesicle, cytosol, endoplasmic reticulum, glutamatergic synapse, nucleoplasm, nucleus, postsynapse, ribonucleoprotein complex, sarcoplasm
Pathways: AMPK signaling pathway - Mus musculus (mouse), HuR (ELAVL1) binds and stabilizes mRNA, IL-17 signaling pathway - Mus musculus (mouse), Metabolism of RNA, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: P70372
Entrez ID: 15568
|
Does Knockout of Sergef in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Sergef
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sergef (secretion regulating guanine nucleotide exchange factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of protein secretion; MF: guanyl-nucleotide exchange factor activity, molecular_function; CC: cellular_component, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q80YD6
Entrez ID: 27414
|
Does Knockout of Otulin in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,141
|
Knockout
|
Otulin
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Otulin (OTU deubiquitinase with linear linkage specificity)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, angiogenesis, immune system process, innate immune response, negative regulation of NF-kappaB transcription factor activity, negative regulation of inflammatory response, nucleotide-binding oligomerization domain containing 2 signaling pathway, protein linear deubiquitination, proteolysis, regulation of canonical Wnt signaling pathway, regulation of tumor necrosis factor-mediated signaling pathway, sprouting angiogenesis; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: LUBAC complex, cytoplasm
Pathways: Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UniProt: Q3UCV8
Entrez ID: 432940
|
Does Knockout of Tex48 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tex48
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tex48 (testis expressed 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA81
Entrez ID: 75524
|
Does Knockout of Zfp869 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zfp869
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp869 (zinc finger protein 869)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8C0L3, Q9DC47, A0A571BEQ6, A0A571BDH3, A0A571BFX2
Entrez ID: 66869
|
Does Knockout of Rpl35a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Rpl35a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rpl35a (ribosomal protein L35A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, mitochondrion, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O55142
Entrez ID: 57808
|
Does Knockout of Trav19 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Trav19
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Trav19 (T cell receptor alpha variable 19)
Type: other
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, biological_process, immune system process; MF: molecular_function, peptide antigen binding; CC: T cell receptor complex, cellular_component
Pathways:
UniProt:
Entrez ID: 547428
|
Does Knockout of Glra1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Glra1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Glra1 (glycine receptor, alpha 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome reaction, adult walking behavior, cellular response to amino acid stimulus, cellular response to ethanol, cellular response to zinc ion, chemical synaptic transmission, chloride transmembrane transport, chloride transport, excitatory postsynaptic potential, inhibitory postsynaptic potential, monoatomic anion transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, negative regulation of transmission of nerve impulse, neuromuscular process, neuromuscular process controlling posture, neuronal action potential, neuropeptide signaling pathway, positive regulation of acrosome reaction, regulation of membrane potential, regulation of presynaptic membrane potential, regulation of respiratory gaseous exchange, regulation of respiratory gaseous exchange by nervous system process, response to alcohol, righting reflex, startle response, synaptic transmission, glycinergic, visual perception; MF: chloride channel activity, excitatory extracellular ligand-gated monoatomic ion channel activity, extracellular ligand-gated monoatomic ion channel activity, extracellularly glycine-gated chloride channel activity, extracellularly glycine-gated ion channel activity, glycine binding, identical protein binding, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, metal ion binding, monoatomic ion channel activity, protein-containing complex binding, taurine binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, zinc ion binding; CC: calyx of Held, cell projection, chloride channel complex, dendrite, external side of plasma membrane, glycinergic synapse, inhibitory synapse, intracellular membrane-bounded organelle, membrane, neuron projection, neuronal cell body, perikaryon, plasma membrane, postsynaptic membrane, postsynaptic specialization membrane, presynaptic membrane, synapse, synaptic membrane
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses
UniProt: Q64018
Entrez ID: 14654
|
Does Knockout of Serpina1d in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Serpina1d
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Serpina1d (serine (or cysteine) peptidase inhibitor, clade A, member 1D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to chromate, response to cytokine, response to lead ion, response to methanol, response to peptide hormone; MF: endopeptidase inhibitor activity, identical protein binding, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse)
UniProt: Q00897
Entrez ID: 20703
|
Does Knockout of Zfp932 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Zfp932
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp932 (zinc finger protein 932)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-binding transcription factor activity, negative regulation of cell differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, histone deacetylase binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: E9QAG8
Entrez ID: 69504
|
Does Knockout of Emx1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Emx1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Emx1 (empty spiracles homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, brain morphogenesis, central nervous system development, cerebral cortex development, cerebral cortex neuron differentiation, cerebral cortex regionalization, homeostasis of number of cells, in utero embryonic development, neuroepithelial cell differentiation, neuron differentiation, neuron projection extension, post-embryonic development, radial glial cell differentiation, regulation of DNA-templated transcription, regulation of oligodendrocyte progenitor proliferation, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus, telencephalon development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q04742
Entrez ID: 13796
|
Does Knockout of Tatdn2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Tatdn2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tatdn2 (TatD DNase domain containing 2)
Type: protein-coding
Summary: Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human TATDN2 (TatD DNase domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: hydrolase activity, acting on ester bonds, molecular_function
Pathways:
UniProt: F8VQE6, B7ZNL9, F7CWI0, F6W3K2
Entrez ID: 381801
|
Does Knockout of Mgl2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mgl2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mgl2 (macrophage galactose N-acetyl-galactosamine specific lectin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: D-mannose binding, carbohydrate binding, fucose binding, pattern recognition receptor activity; CC: external side of plasma membrane, membrane
Pathways:
UniProt: Q8JZN1, A9XX86, F6QSC4
Entrez ID: 216864
|
Does Knockout of Asb5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Asb5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Asb5 (ankyrin repeat and SOCs box-containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, positive regulation of protein catabolic process, protein ubiquitination
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9D1A4
Entrez ID: 76294
|
Does Knockout of Abca5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Abca5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Abca5 (ATP-binding cassette, sub-family A member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, high-density lipoprotein particle remodeling, lipid transport, negative regulation of macrophage derived foam cell differentiation, positive regulation of reverse cholesterol transport, regulation of cholesterol efflux, reverse cholesterol transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, lipid transporter activity, nucleotide binding; CC: Golgi apparatus, Golgi membrane, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Transport of small molecules
UniProt: Q8K448
Entrez ID: 217265
|
Does Knockout of Ebf3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ebf3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ebf3 (early B cell factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: O08791
Entrez ID: 13593
|
Does Knockout of Nkx1-2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Nkx1-2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nkx1-2 (NK1 homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: nucleolus, nucleus
Pathways:
UniProt: P42580
Entrez ID: 20231
|
Does Knockout of Hdgfl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Hdgfl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hdgfl1 (HDGF like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q2VPR5
Entrez ID: 15192
|
Does Knockout of Gpr26 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Gpr26
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gpr26 (G protein-coupled receptor 26)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in central nervous system. Orthologous to human GPR26 (G protein-coupled receptor 26). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8BZA7
Entrez ID: 233919
|
Does Knockout of Mettl14 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Mettl14
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Mettl14 (methyltransferase 14, N6-adenosine-methyltransferase subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cell differentiation, forebrain radial glial cell differentiation, gliogenesis, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of hematopoietic progenitor cell differentiation, positive regulation of translation, regulation of neuron differentiation, response to nutrient levels, spermatogenesis, stem cell population maintenance; MF: RNA binding, S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, catalytic activity, acting on a nucleic acid, mRNA binding, mRNA m(6)A methyltransferase activity, protein binding; CC: RNA N6-methyladenosine methyltransferase complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA
UniProt: Q3UIK4
Entrez ID: 210529
|
Does Knockout of Eftud2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Eftud2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eftud2 (elongation factor Tu GTP binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: GTP binding, GTPase activity, U5 snRNA binding, nucleotide binding, protein binding; CC: Cajal body, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: O08810
Entrez ID: 20624
|
Does Knockout of Sgf29 in Microglial Cell Line causally result in response to virus?
| 1
| 2,429
|
Knockout
|
Sgf29
|
response to virus
|
Microglial Cell Line
|
Gene: Sgf29 (SAGA complex associated factor 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of macromolecule metabolic process, regulation of nucleobase-containing compound metabolic process, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, transcription initiation-coupled chromatin remodeling; MF: histone H3K36me3 reader activity, histone H3K4me3 reader activity, methylation-dependent protein binding; CC: ATAC complex, SAGA complex, SAGA-type complex, mitotic spindle, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q9DA08
Entrez ID: 75565
|
Does Knockout of Dcaf6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dcaf6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dcaf6 (DDB1 and CUL4 associated factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein ubiquitination; MF: transcription coactivator activity; CC: Cul4-RING E3 ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9DC22
Entrez ID: 74106
|
Does Knockout of Ndc80 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ndc80
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ndc80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/MI transition of meiotic cell cycle, attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, centrosome duplication, chromosome organization, chromosome segregation, establishment of mitotic spindle orientation, kinetochore organization, metaphase chromosome alignment, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle assembly involved in female meiosis I, spindle organization; MF: cyclin binding, identical protein binding, kinetochore adaptor activity, microtubule binding, protein binding; CC: Ndc80 complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, kinetochore, nuclear speck, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9D0F1
Entrez ID: 67052
|
Does Knockout of Ctr9 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ctr9
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ctr9 (CTR9 homolog, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: Enables SH2 domain binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and endodermal cell fate commitment. Acts upstream of or within blastocyst development and negative regulation of gene expression, epigenetic. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in cerebral cortex and telencephalon. Orthologous to human CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, blastocyst hatching, cell surface receptor signaling pathway via JAK-STAT, cellular response to lipopolysaccharide, chromatin organization, endodermal cell fate commitment, inner cell mass cell differentiation, interleukin-6-mediated signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II, trophectodermal cell differentiation; MF: RNA polymerase II complex binding, SH2 domain binding, protein binding; CC: Cdc73/Paf1 complex, euchromatin, nuclear speck, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62018
Entrez ID: 22083
|
Does Knockout of Rbm26 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rbm26
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbm26 (RNA binding motif protein 26)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and submandibular gland. Orthologous to human RBM26 (RNA binding motif protein 26). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, metal ion binding, nucleic acid binding, zinc ion binding
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q6NZN0
Entrez ID: 74213
|
Does Knockout of 4930455H04Rik in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
4930455H04Rik
|
phagocytosis
|
macrophage
|
Gene: 4930455H04Rik (RIKEN cDNA 4930455H04 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 74654
|
Does Knockout of Trim43a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Trim43a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Trim43a (tripartite motif-containing 43A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, protein kinase binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q3TL54
Entrez ID: 547109
|
Does Knockout of St6galnac2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
St6galnac2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: St6galnac2 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate derivative biosynthetic process, protein O-linked glycosylation, protein glycosylation, protein sialylation; MF: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Termination of O-glycan biosynthesis
UniProt: P70277
Entrez ID: 20446
|
Does Knockout of Sphk2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sphk2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sphk2 (sphingosine kinase 2)
Type: protein-coding
Summary: This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: blood vessel development, brain development, cellular response to phorbol 13-acetate 12-myristate, female pregnancy, intracellular signal transduction, lipid metabolic process, negative regulation of cell growth, positive regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of ceramide biosynthetic process, positive regulation of cytokine production involved in immune response, positive regulation of interleukin-13 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation involved in immune response, positive regulation of mast cell degranulation, positive regulation of tumor necrosis factor production, regulation of ATP biosynthetic process, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, regulation of ceramide biosynthetic process, regulation of cytochrome-c oxidase activity, regulation of cytokine production, regulation of reactive oxygen species biosynthetic process, regulation of transport, sphinganine-1-phosphate biosynthetic process, sphingosine biosynthetic process, sphingosine metabolic process, sphingosine-1-phosphate receptor signaling pathway, transcription initiation-coupled chromatin remodeling; MF: ATP binding, histone binding, kinase activity, nucleotide binding, protein binding, sphingosine kinase activity, sphingosine-1-phosphate receptor activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, intracellular membrane-bounded organelle, lysosomal membrane, lysosome, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, nucleosome, nucleus, plasma membrane
Pathways: Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q9JIA7
Entrez ID: 56632
|
Does Knockout of Lin9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Lin9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lin9 (lin-9 DREAM MuvB core complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA-templated transcription, regulation of cell cycle, regulation of transcription by RNA polymerase II; CC: nucleoplasm, nucleus, transcription repressor complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), G0 and Early G1, Mitotic G1 phase and G1/S transition
UniProt: Q8C735
Entrez ID: 72568
|
Does Knockout of Foxi1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Foxi1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Foxi1 (forkhead box I1)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within inner ear morphogenesis. Predicted to be located in nucleolus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study Pendred Syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to human FOXI1 (forkhead box I1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, inner ear morphogenesis, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q922I5
Entrez ID: 14233
|
Does Knockout of Klrc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Klrc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Klrc1 (killer cell lectin-like receptor subfamily C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune response-regulating cell surface receptor signaling pathway, immune system process, innate immune response, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell activation, regulation of natural killer cell mediated cytotoxicity, stimulatory C-type lectin receptor signaling pathway; MF: HLA-E specific inhibitory MHC class Ib receptor activity, MHC class I protein complex binding, MHC class Ib receptor activity, carbohydrate binding, inhibitory MHC class Ib receptor activity, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), DAP12 interactions, DAP12 signaling, Graft-versus-host disease - Mus musculus (mouse), Immune System, Innate Immune System, Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q9Z202, Q9WU32, E9QAJ6, Q9WVJ8
Entrez ID: 16641
|
Does Knockout of Vil1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Vil1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vil1 (villin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament capping, actin filament depolymerization, actin filament polymerization, actin filament severing, actin polymerization or depolymerization, apoptotic process, barbed-end actin filament capping, cellular response to epidermal growth factor stimulus, cellular response to hepatocyte growth factor stimulus, cytoplasmic actin-based contraction involved in cell motility, cytoskeleton organization, epidermal growth factor receptor signaling pathway, epithelial cell differentiation, intestinal D-glucose absorption, microvillus assembly, positive regulation of actin filament bundle assembly, positive regulation of actin filament depolymerization, positive regulation of cell migration, positive regulation of epithelial cell migration, positive regulation of lamellipodium morphogenesis, positive regulation of multicellular organism growth, positive regulation of protein localization to plasma membrane, regulation of actin nucleation, regulation of cell shape, regulation of lamellipodium morphogenesis, regulation of microvillus length, regulation of plasma membrane bounded cell projection organization, regulation of wound healing, response to bacterium, terminal web assembly; MF: actin binding, actin filament binding, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, identical protein binding, lysophosphatidic acid binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein homodimerization activity; CC: actin cytoskeleton, actin filament bundle, brush border, cell projection, cytoplasm, cytoskeleton, filopodium, filopodium tip, lamellipodium, microvillus, plasma membrane, ruffle
Pathways:
UniProt: Q62468
Entrez ID: 22349
|
Does Knockout of Pbrm1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Pbrm1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pbrm1 (polybromo 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, blood vessel remodeling, cardiac vascular smooth muscle cell development, chromatin organization, chromatin remodeling, epicardium-derived cardiac endothelial cell differentiation, heart development, heart morphogenesis, negative regulation of cell population proliferation, placenta development, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of dendritic spine development, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vasculogenesis involved in coronary vascular morphogenesis; MF: DNA binding, chromatin binding, protein binding; CC: RSC-type complex, SWI/SNF complex, chromatin, chromosome, kinetochore, nuclear matrix, nucleoplasm, nucleus
Pathways: Hepatocellular carcinoma - Mus musculus (mouse)
UniProt: Q8BSQ9
Entrez ID: 66923
|
Does Knockout of Mia2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Mia2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mia2 (MIA SH3 domain ER export factor 2)
Type: protein-coding
Summary: This gene encodes a protein that is involved in endoplasmic reticulum-to-Golgi trafficking and regulation of cholesterol metabolism. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding diverse isoforms. A mutation in this gene (couch-potato or cpto) may result in low levels of plasma cholesterol and triglycerides. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: cholesterol homeostasis, endoplasmic reticulum to Golgi vesicle-mediated transport, lipoprotein transport, protein exit from endoplasmic reticulum, protein localization to endoplasmic reticulum exit site, protein secretion, triglyceride homeostasis, vesicle cargo loading; MF: cargo receptor activity; CC: endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q91ZV0
Entrez ID: 338320
|
Does Knockout of Hbq1b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Hbq1b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hbq1b (hemoglobin, theta 1B)
Type: protein-coding
Summary: This gene is one of two mouse theta-globin genes found in the alpha-globin gene cluster on chromosome 11. This gene represents the T1 (or 5') theta-globin gene described in PMIDs 18245844 and 11157800, respectively. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: erythrocyte development, oxygen transport; MF: heme binding, metal ion binding, oxygen binding, oxygen carrier activity; CC: haptoglobin-hemoglobin complex, hemoglobin complex
Pathways:
UniProt: Q3U0A6
Entrez ID: 544763
|
Does Knockout of Dmap1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Dmap1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dmap1 (DNA methyltransferase 1-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways:
UniProt: Q9JI44
Entrez ID: 66233
|
Does Knockout of Lrrc56 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Lrrc56
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Lrrc56 (leucine rich repeat containing 56)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell projection organization; CC: cell projection, cellular_component, cilium
Pathways:
UniProt: Q8K375
Entrez ID: 70552
|
Does Knockout of Gm14151 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Gm14151
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm14151 (predicted gene 14151)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cellular response to glucose starvation; MF: ATP binding, kinase activity, molecular_function, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: A2AQX6
Entrez ID: 433486
|
Does Knockout of Atp6v1g1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Atp6v1g1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Atp6v1g1 (ATPase, H+ transporting, lysosomal V1 subunit G1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, presynapse, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9CR51
Entrez ID: 66290
|
Does Knockout of Qtrt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Qtrt2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Qtrt2 (queuine tRNA-ribosyltransferase accessory subunit 2)
Type: protein-coding
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA binding activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane. Part of protein-containing complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA binding, tRNA-guanosine(34) queuine transglycosylase activity, zinc ion binding; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: B8ZXI1
Entrez ID: 106248
|
Does Knockout of Adprh in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Adprh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adprh (ADP-ribosylarginine hydrolase)
Type: protein-coding
Summary: Enables ADP-ribosylarginine hydrolase activity. Involved in protein modification process. Predicted to be located in extracellular space. Is expressed in cerebral cortex. Orthologous to human ADPRH (ADP-ribosylarginine hydrolase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: protein de-ADP-ribosylation, protein modification process; MF: ADP-ribosylarginine hydrolase activity, hydrolase activity, magnesium ion binding, metal ion binding, potassium ion binding; CC: extracellular space
Pathways:
UniProt: P54923
Entrez ID: 11544
|
Does Knockout of Lcp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Lcp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lcp1 (lymphocyte cytosolic protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation involved in immune response, actin cytoskeleton organization, actin filament bundle assembly, actin filament network formation, animal organ regeneration, cell migration, extracellular matrix disassembly, positive regulation of podosome assembly, protein kinase A signaling, regulation of intracellular protein transport, response to wounding; MF: GTPase binding, actin binding, actin filament binding, calcium ion binding, identical protein binding, integrin binding, metal ion binding, protein binding; CC: actin cytoskeleton, actin filament, actin filament bundle, anchoring junction, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, focal adhesion, glial cell projection, membrane, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, podosome, ruffle, ruffle membrane, stress fiber
Pathways:
UniProt: Q61233
Entrez ID: 18826
|
Does Knockout of Fst in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Fst
|
cell proliferation
|
Regulatory T cell
|
Gene: Fst (follistatin)
Type: protein-coding
Summary: The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: BMP signaling pathway, ameloblast differentiation, cell differentiation, cellular response to growth factor stimulus, female gonad development, gamete generation, hair follicle morphogenesis, hematopoietic progenitor cell differentiation, keratinocyte proliferation, negative regulation of activin receptor signaling pathway, negative regulation of epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, odontogenesis of dentin-containing tooth, pattern specification process, positive regulation of hair follicle development, regulation of BMP signaling pathway, skeletal system development; MF: activin binding, activin receptor antagonist activity, heparan sulfate proteoglycan binding; CC: cytoplasm, extracellular region, extracellular space, nucleolus, nucleus
Pathways: Antagonism of Activin by Follistatin, Signal Transduction, Signaling by Activin, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P47931
Entrez ID: 14313
|
Does Knockout of Oaz1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Oaz1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Oaz1 (ornithine decarboxylase antizyme 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: cellular response to leptomycin B, cellular response to polyamine macromolecule, negative regulation of ornithine catabolic process, negative regulation of polyamine transmembrane transport, polyamine biosynthetic process, polyamine metabolic process, positive regulation of intracellular protein transport, positive regulation of proteasomal protein catabolic process, positive regulation of protein catabolic process, viral translational frameshifting; MF: enzyme binding, ornithine decarboxylase inhibitor activity, protein binding, protein-containing complex binding; CC: cytoplasm, nucleus
Pathways: Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, Regulation of ornithine decarboxylase (ODC), putrescine biosynthesis III, spermine biosynthesis II
UniProt: P54369
Entrez ID: 18245
|
Does Knockout of Trappc4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Trappc4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Trappc4 (trafficking protein particle complex 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, autophagy, dendrite development, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, Golgi stack, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, dendrite, endoplasmic reticulum, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynaptic active zone, synapse, synaptic vesicle, vesicle
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9ES56
Entrez ID: 60409
|
Does Knockout of Txnl4a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Txnl4a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Txnl4a (thioredoxin-like 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell division, mRNA processing, mRNA splicing, via spliceosome; MF: molecular_function, protein-N-terminal amino-acid acetyltransferase activity; CC: Golgi apparatus, NatA complex, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, centrosome, ciliary basal body, cilium, cytoplasm, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P83877
Entrez ID: 27366
|
Does Knockout of Dpys in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Dpys
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dpys (dihydropyrimidinase)
Type: protein-coding
Summary: Enables dihydropyrimidinase activity and phosphoprotein binding activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Is active in cytosol. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, beta-alanine metabolic process, dCMP catabolic process, dTMP catabolic process, dUMP catabolic process, pyrimidine nucleobase catabolic process, thymine catabolic process, uracil catabolic process, uracil metabolic process; MF: amino acid binding, dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, identical protein binding, metal ion binding, phosphoprotein binding, thymine binding, uracil binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), uracil degradation II (reductive)
UniProt: Q9EQF5
Entrez ID: 64705
|
Does Knockout of Abhd1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Abhd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abhd1 (abhydrolase domain containing 1)
Type: protein-coding
Summary: Predicted to enable acetylesterase activity and monoacylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Predicted to be located in membrane. Is expressed in several structures, including clavicle; genitourinary system; liver; meninges; and thymus primordium. Orthologous to human ABHD1 (abhydrolase domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process; MF: acetylesterase activity, carboxylic ester hydrolase activity, hydrolase activity, monoacylglycerol lipase activity
Pathways:
UniProt: Q9QZC8
Entrez ID: 57742
|
Does Knockout of Dhrs13 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dhrs13
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dhrs13 (dehydrogenase/reductase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SS80
Entrez ID: 70451
|
Does Knockout of Atp4b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Atp4b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Atp4b (ATPase, H+/K+ exchanging, beta polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, monoatomic ion transport, pH reduction, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein glycosylation, proton transmembrane transport, regulation of proton transport, response to lipopolysaccharide, sodium ion export across plasma membrane, sodium ion transport; MF: ATPase activator activity, P-type potassium:proton transporter activity, heterocyclic compound binding; CC: apical plasma membrane, endoplasmic reticulum, membrane, plasma membrane, potassium:proton exchanging ATPase complex, sodium:potassium-exchanging ATPase complex
Pathways: Collecting duct acid secretion - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Ion channel transport, Ion transport by P-type ATPases, Oxidative phosphorylation - Mus musculus (mouse), Transport of small molecules
UniProt: P50992
Entrez ID: 11945
|
Does Knockout of Apaf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Apaf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Apaf1 (apoptotic peptidase activating factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, apoptotic signaling pathway, brain development, cardiac muscle cell apoptotic process, cell differentiation, cellular response to transforming growth factor beta stimulus, forebrain development, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, kidney development, neural tube closure, neuron apoptotic process, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, regulation of apoptotic DNA fragmentation, regulation of apoptotic process, response to hypoxia, response to nutrient, system development; MF: ADP binding, ATP binding, cysteine-type endopeptidase activator activity involved in apoptotic process, heat shock protein binding, identical protein binding, nucleotide binding; CC: apoptosome, cytoplasm, cytosol, nucleus, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: O88879
Entrez ID: 11783
|
Does Knockout of Krtap26-1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Krtap26-1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Krtap26-1 (keratin associated protein 26-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, structural molecule activity; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways:
UniProt: Q9D7N2
Entrez ID: 69533
|
Does Knockout of Ncl in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ncl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ncl (nucleolin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, endocytosis, negative regulation of apoptotic process, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of interleukin-6 production, positive regulation of mRNA splicing, via spliceosome, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of tumor necrosis factor production, regulation of RNA metabolic process, regulation of gene expression, regulation of rRNA processing; MF: DNA binding, DNA topoisomerase binding, ErbB-4 class receptor binding, PH domain binding, RNA binding, calcium ion binding, histone binding, identical protein binding, insulin receptor substrate binding, laminin binding, mRNA 5'-UTR binding, nucleic acid binding, protein binding, rRNA primary transcript binding, selenocysteine insertion sequence binding, sequence-specific DNA binding, signaling receptor binding, single-stranded DNA binding, telomeric DNA binding; CC: cell cortex, cell surface, chromosome, cornified envelope, cytoplasm, cytoplasmic ribonucleoprotein granule, dense fibrillar component, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P09405
Entrez ID: 17975
|
Does Knockout of Sgce in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Sgce
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sgce (sarcoglycan, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cell projection, cytoplasm, cytoskeleton, dendrite, dendrite membrane, dystrophin-associated glycoprotein complex, membrane, plasma membrane, sarcoglycan complex, sarcolemma
Pathways: Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Non-integrin membrane-ECM interactions
UniProt: O70258
Entrez ID: 20392
|
Does Knockout of Fthl17a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Fthl17a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fthl17a (ferritin, heavy polypeptide-like 17, member A)
Type: protein-coding
Summary: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be active in cytoplasm. Orthologous to several human genes including FTHL17 (ferritin heavy chain like 17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular iron ion homeostasis, iron ion transport; MF: ferric iron binding, ferrous iron binding, metal ion binding
Pathways:
UniProt: Q9DAX0
Entrez ID: 71996
|
Does Knockout of Prpf8 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Prpf8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Prpf8 (pre-mRNA processing factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, mRNA processing, mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: K63-linked polyubiquitin modification-dependent protein binding, RNA binding, U1 snRNA binding, U2 snRNA binding, U5 snRNA binding, U6 snRNA binding, metallopeptidase activity, peptidase activity, pre-mRNA intronic binding; CC: U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, nuclear speck, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q99PV0
Entrez ID: 192159
|
Does Knockout of Dock8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Dock8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dock8 (dedicator of cytokinesis 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to chemokine, dendritic cell migration, immunological synapse formation, memory T cell proliferation, negative regulation of T cell apoptotic process, positive regulation of T cell migration, positive regulation of establishment of T cell polarity, regulation of Rho protein signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cell leading edge, cell projection, cytoplasm, cytosol, lamellipodium membrane, leading edge membrane, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, Factors involved in megakaryocyte development and platelet production, Hemostasis, RAC1 GTPase cycle, RHO GTPase cycle, RHOJ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, cyclic AMP biosynthesis
UniProt: Q8C147
Entrez ID: 76088
|
Does Knockout of Brap in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Brap
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Brap (BRCA1 associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, negative regulation of signal transduction, protein ubiquitination; MF: identical protein binding, metal ion binding, nuclear localization sequence binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, ubiquitin ligase complex
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF activation, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: Q99MP8
Entrez ID: 72399
|
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