prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Spryd4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Spryd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Spryd4 (SPRY domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion, nucleus
Pathways:
UniProt: Q91WK1
Entrez ID: 66701
|
Does Knockout of Depdc7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Depdc7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Depdc7 (DEP domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q91WS7
Entrez ID: 211896
|
Does Knockout of Ears2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ears2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015].
Gene Ontology: BP: glutamyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for mitochondrial protein translation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, glutamate-tRNA ligase activity, glutamate-tRNA(Gln) ligase activity, ligase activity, nucleotide binding, tRNA binding, zinc ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CXJ1
Entrez ID: 67417
|
Does Knockout of Hnrnpm in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Hnrnpm
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hnrnpm (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, positive regulation of protein import, positive regulation of protein localization to nucleus, regulation of postsynapse organization; MF: RNA binding, calcium-dependent protein binding, mRNA binding, nucleic acid binding, protein antigen binding, protein domain specific binding; CC: catalytic step 2 spliceosome, cell surface, cytoplasm, glutamatergic synapse, nuclear matrix, nucleoplasm, nucleus, paraspeckles, postsynaptic density, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: Q9D0E1
Entrez ID: 76936
|
Does Knockout of Gm17019 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Gm17019
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gm17019 (predicted gene 17019)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N6W5
Entrez ID: 66773
|
Does Knockout of Tll1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tll1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tll1 (tolloid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral pattern formation, protein processing, proteolysis; MF: calcium ion binding, collagen binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A0A1B0GRW8, G3X9F5
Entrez ID: 21892
|
Does Knockout of Chtf8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Chtf8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chtf8 (CTF8, chromosome transmission fidelity factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, mitotic sister chromatid cohesion, positive regulation of DNA-directed DNA polymerase activity; MF: DNA binding, DNA clamp loader activity, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance
UniProt: P0CG14, P0CG15
Entrez ID: 214987
|
Does Knockout of Atp8b2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Atp8b2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atp8b2 (ATPase, class I, type 8B, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylcholine flippase activity, phosphatidylcholine floppase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, phospholipid-translocating ATPase complex, plasma membrane, trans-Golgi network
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: P98199
Entrez ID: 54667
|
Does Knockout of Hmgn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Hmgn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hmgn1 (high mobility group nucleosomal binding domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, post-embryonic camera-type eye morphogenesis, pyrimidine dimer repair by nucleotide-excision repair, regulation of development, heterochronic, regulation of epithelial cell proliferation, regulation of transcription by RNA polymerase II, response to UV-B, response to UV-C, transcription-coupled nucleotide-excision repair; MF: DNA binding, chromatin binding, nucleosomal DNA binding, protein binding; CC: chromatin, cytoplasm, female germ cell nucleus, nucleoplasm, nucleus
Pathways:
UniProt: P18608
Entrez ID: 15312
|
Does Knockout of Elob in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Elob
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Elob (elongin B)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity; transcription corepressor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in target-directed miRNA degradation and transcription initiation at RNA polymerase II promoter. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in brain; brown fat; dorsal root ganglion; genitourinary system; and limb. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein ubiquitination, target-directed miRNA degradation, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: protein binding, protein-containing complex binding, transcription coactivator activity, transcription corepressor binding, ubiquitin protein ligase binding; CC: Cul2-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, VCB complex, cytoplasm, cytosol, elongin complex, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIF-1 signaling pathway - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Renal cell carcinoma - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Signaling by CSF3 (G-CSF), TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, Translation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P62869
Entrez ID: 67673
|
Does Knockout of Tmem185a in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tmem185a
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tmem185a (transmembrane protein 185A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell projection, dendrite, membrane
Pathways:
UniProt: A2AF53
Entrez ID: 236848
|
Does Knockout of Zfp839 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zfp839
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zfp839 (zinc finger protein 839)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9CSB3, E9PUU5, B2RWW3, A0A1Y7VNF0, A0A1Y7VL21
Entrez ID: 72805
|
Does Knockout of Atp6v1g1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Atp6v1g1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Atp6v1g1 (ATPase, H+ transporting, lysosomal V1 subunit G1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, presynapse, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9CR51
Entrez ID: 66290
|
Does Knockout of Eef1a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Eef1a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eef1a1 (eukaryotic translation elongation factor 1 alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to epidermal growth factor stimulus, translation, translational elongation; MF: GTP binding, GTPase activity, calmodulin binding, heterocyclic compound binding, hydrolase activity, identical protein binding, kinase activator activity, kinase binding, mRNA binding, molecular adaptor activity, nucleotide binding, protein binding, protein kinase binding, tRNA binding, translation elongation factor activity; CC: GABA-ergic synapse, cortical actin cytoskeleton, cytoplasm, cytosol, cytosolic ribosome, membrane, myelin sheath, nucleolus, nucleus, plasma membrane, postsynapse, ribosome, ruffle membrane
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Elongation, HSF1 activation, Immune System, Innate Immune System, Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Metabolism of proteins, Neutrophil degranulation, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Protein methylation, Translation
UniProt: P10126
Entrez ID: 13627
|
Does Knockout of Rfc3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rfc3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rfc3 (replication factor C (activator 1) 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP-dependent activity, acting on DNA, DNA binding, DNA clamp loader activity, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleus, protein-containing complex
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8R323
Entrez ID: 69263
|
Does Knockout of Vps72 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Vps72
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vps72 (vacuolar protein sorting 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, somatic stem cell population maintenance, transcription initiation-coupled chromatin remodeling; MF: DNA binding, histone binding, histone chaperone activity; CC: NuA4 histone acetyltransferase complex, nuclear speck, nucleosome, nucleus, protein-containing complex
Pathways:
UniProt: Q62481
Entrez ID: 21427
|
Does Knockout of Esco2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Esco2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Located in chromocenter and chromosome. Is expressed in several structures, including alimentary system; brain; gonad; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, hematopoietic progenitor cell differentiation, mitotic sister chromatid cohesion, protein localization to chromatin, regulation of DNA replication; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, XY body, cell junction, chromatin, chromocenter, chromosome, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q8CIB9
Entrez ID: 71988
|
Does Knockout of Tmc4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Tmc4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tmc4 (transmembrane channel-like gene family 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, sensory perception of salty taste; MF: mechanosensitive monoatomic ion channel activity, voltage-gated chloride channel activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q7TQ65
Entrez ID: 353499
|
Does Knockout of Ap3b1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ap3b1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ap3b1 (adaptor-related protein complex 3, beta 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, anterograde synaptic vesicle transport, antigen processing and presentation, antigen processing and presentation, exogenous lipid antigen via MHC class Ib, blood coagulation, cell morphogenesis, clathrin-coated vesicle cargo loading, AP-3-mediated, establishment of protein localization to mitochondrial membrane involved in mitochondrial fission, gene expression, granulocyte differentiation, hematopoietic progenitor cell differentiation, homeostasis of number of cells, inflammatory response, intracellular protein transport, intracellular zinc ion homeostasis, lung development, lung morphogenesis, lysosome organization, mRNA transcription by RNA polymerase II, melanosome assembly, melanosome organization, membrane organization, pigmentation, platelet dense granule organization, positive regulation of NK T cell differentiation, positive regulation of transcription by RNA polymerase II, protein localization to cell surface, protein targeting, protein targeting to lysosome, protein transport, respiratory system process, single fertilization, skin epidermis development, spermatogenesis, toll-like receptor signaling pathway, vesicle-mediated transport; MF: GTP-dependent protein binding, protein phosphatase binding; CC: AP-3 adaptor complex, Golgi apparatus, axon cytoplasm, clathrin adaptor complex, clathrin-coated vesicle membrane, cytoplasmic vesicle, early endosome, membrane, membrane coat, microvesicle, mitochondrion, trans-Golgi network
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Mus musculus (mouse), Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9Z1T1
Entrez ID: 11774
|
Does Knockout of Gm1587 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gm1587
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gm1587 (predicted gene 1587)
Type: ncRNA
Summary: predicted gene 1587
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 380920
|
Does Knockout of Ccr7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Ccr7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccr7 (C-C motif chemokine receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CCL19-activated CCR7 signaling pathway, CCL21-activated CCR7 signaling pathway, G protein-coupled receptor signaling pathway, actin cytoskeleton organization, calcium-mediated signaling, cell chemotaxis, cellular response to cytokine stimulus, cellular response to prostaglandin E stimulus, chemotaxis, establishment of T cell polarity, homeostasis of number of cells, immune response, inflammatory response, lymph node development, lymphocyte chemotaxis across high endothelial venule, lymphocyte migration into lymph node, mature conventional dendritic cell differentiation, myeloid dendritic cell chemotaxis, negative regulation of interleukin-12 production, negative regulation of leukocyte apoptotic process, negative thymic T cell selection, positive regulation of JNK cascade, positive regulation of Rac protein signal transduction, positive regulation of T cell chemotaxis, positive regulation of T cell costimulation, positive regulation of T cell proliferation, positive regulation of T cell receptor signaling pathway, positive regulation of T-helper 1 cell differentiation, positive regulation of cell motility, positive regulation of cytosolic calcium ion concentration, positive regulation of dendritic cell antigen processing and presentation, positive regulation of dendritic cell chemotaxis, positive regulation of filopodium assembly, positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation, positive regulation of humoral immune response, positive regulation of hypersensitivity, positive regulation of immunological synapse formation, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of macrophage chemotaxis, positive regulation of neutrophil chemotaxis, positive regulation of phagocytosis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of receptor-mediated endocytosis, positive regulation of thymocyte migration, positive regulation of tumor necrosis factor production, regulation of Cdc42 protein signal transduction, regulation of dendritic cell dendrite assembly, regulation of interleukin-1 beta production, regulation of tolerance induction to self antigen, regulation of type II interferon production, release of sequestered calcium ion into cytosol, response to lipopolysaccharide, response to nitric oxide, response to prostaglandin E, signal transduction; MF: C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity, G protein-coupled receptor activity, chemokine (C-C motif) ligand 19 binding, chemokine (C-C motif) ligand 21 binding, chemokine receptor activity, protein binding; CC: cell surface, external side of plasma membrane, membrane, mitochondrion, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P47774
Entrez ID: 12775
|
Does Knockout of Nedd1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Nedd1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Nedd1 (neural precursor cell expressed, developmentally down-regulated gene 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule depolymerization, microtubule nucleation, microtubule polymerization or depolymerization, mitotic cell cycle, regulation of establishment of protein localization; CC: apical part of cell, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, fibrillar center, gamma-tubulin ring complex, nucleoplasm, pericentriolar material, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P33215
Entrez ID: 17997
|
Does Knockout of C1rb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
C1rb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: C1rb (complement component 1, r subcomponent B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, classical pathway, immune system process, innate immune response, killing of cells of another organism, opsonization, protein maturation, proteolysis, zymogen activation; MF: calcium ion binding, hydrolase activity, identical protein binding, metal ion binding, molecular sequestering activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: blood microparticle, cell surface, complement component C1 complex, extracellular region, extracellular space, symbiont cell surface
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: Q8CFG9
Entrez ID: 667277
|
Does Knockout of Mycbpap in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Mycbpap
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mycbpap (MYCBP associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, chemical synaptic transmission, spermatogenesis; CC: cytoplasm, membrane, synapse
Pathways:
UniProt: Q5SUV2
Entrez ID: 104601
|
Does Knockout of Rnpc3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rnpc3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rnpc3 (RNA-binding region (RNP1, RRM) containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA splicing, via spliceosome; MF: RNA binding, U12 snRNA binding, nucleic acid binding, pre-mRNA intronic binding; CC: U12-type spliceosomal complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q3UZ01
Entrez ID: 67225
|
Does Knockout of Kcnn4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Kcnn4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnn4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transport, cardiac muscle hypertrophy, cell volume homeostasis, establishment of localization in cell, hepatocyte apoptotic process, immune system process, macropinocytosis, monoatomic anion transport, monoatomic ion transmembrane transport, monoatomic ion transport, mononuclear cell migration, negative regulation of cardiac muscle hypertrophy, negative regulation of cell volume, negative regulation of hepatic stellate cell proliferation, phospholipid translocation, positive regulation of G0 to G1 transition, positive regulation of T cell receptor signaling pathway, positive regulation of microglial cell activation, positive regulation of p38MAPK cascade, positive regulation of protein secretion, positive regulation of smooth muscle cell proliferation, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein homotetramerization, regulation of angiotensin levels in blood, regulation of calcium ion import across plasma membrane, regulation of monocyte chemotactic protein-1 production, regulation of protein secretion, regulation of renin secretion into blood stream, regulation of smooth muscle cell proliferation, regulation of tumor necrosis factor production, saliva secretion, stabilization of membrane potential, vascular associated smooth muscle cell migration; MF: calcium-activated potassium channel activity, calmodulin binding, intermediate conductance calcium-activated potassium channel activity, inward rectifier potassium channel activity, potassium channel activity, protein homodimerization activity, protein phosphatase binding, small conductance calcium-activated potassium channel activity; CC: apical plasma membrane, basolateral plasma membrane, cell projection, cytosol, membrane, neuron projection, neuronal cell body, plasma membrane, ruffle membrane, vesicle
Pathways: Ca2+ activated K+ channels, GnRH secretion - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Neuronal System, Potassium Channels, Protein digestion and absorption - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse)
UniProt: O89109
Entrez ID: 16534
|
Does Knockout of Rad54l in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,536
|
Knockout
|
Rad54l
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad54l (RAD54 like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromosome organization, determination of adult lifespan, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via synthesis-dependent strand annealing, reciprocal meiotic recombination, response to ionizing radiation, response to xenobiotic stimulus; MF: ATP binding, ATP hydrolysis activity, ATP-dependent DNA/DNA annealing activity, DNA binding, DNA translocase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding; CC: nucleoplasm, nucleus, protein-containing complex
Pathways: Homologous recombination - Mus musculus (mouse)
UniProt: P70270
Entrez ID: 19366
|
Does Knockout of Rangap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rangap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rangap1 (RAN GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to peptide hormone stimulus, cellular response to vasopressin, negative regulation of protein export from nucleus, nuclear export, protein sumoylation, response to axon injury, signal transduction; MF: GTPase activator activity, RNA binding, small GTPase binding, ubiquitin protein ligase binding; CC: SUMO ligase complex, aggresome, axon cytoplasm, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytoskeleton, cytosol, dendrite, kinetochore, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nucleoplasm, nucleus, perinuclear region of cytoplasm, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, SUMOylation of nuclear envelope proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P46061
Entrez ID: 19387
|
Does Knockout of Hadhb in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Hadhb
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, fatty acid beta-oxidation, fatty acid metabolic process, gene expression, lipid metabolic process; MF: acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, acetyl-CoA C-myristoyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, lncRNA binding, protein binding, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, membrane, mitochondrial fatty acid beta-oxidation multienzyme complex, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial outer membrane, mitochondrion, nucleoplasm
Pathways: 3-oxoadipate degradation, Acyl chain remodeling of CL, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Beta oxidation of hexanoyl-CoA to butanoyl-CoA, Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, Beta oxidation of myristoyl-CoA to lauroyl-CoA, Beta oxidation of octanoyl-CoA to hexanoyl-CoA, Beta oxidation of palmitoyl-CoA to myristoyl-CoA, Fatty acid degradation - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, Phospholipid metabolism, Valine, leucine and isoleucine degradation - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid β-oxidation IV (unsaturated, even number), mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: Q99JY0
Entrez ID: 231086
|
Does Knockout of Midn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Midn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Midn (midnolin)
Type: protein-coding
Summary: This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: negative regulation of insulin secretion, proteasomal ubiquitin-independent protein catabolic process; MF: kinase binding, molecular adaptor activity; CC: cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q3TPJ7
Entrez ID: 59090
|
Does Knockout of Gins4 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Gins4
|
response to virus
|
Microglial Cell Line
|
Gene: Gins4 (GINS complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, double-strand break repair via break-induced replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q99LZ3
Entrez ID: 109145
|
Does Knockout of Depdc5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Depdc5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Depdc5 (DEP domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid starvation, cellular response to nutrient levels, cytoplasmic translation, intracellular signal transduction, negative regulation of TORC1 signaling, negative regulation of translational initiation, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of translational initiation, protein localization to lysosome; MF: GTPase activator activity, protein-containing complex binding, small GTPase binding; CC: Cul3-RING ubiquitin ligase complex, GATOR1 complex, cytoplasm, cytosol, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P61460
Entrez ID: 277854
|
Does Knockout of Sub1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Sub1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sub1 (SUB1 homolog, transcriptional regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of DNA metabolic process, positive regulation of transcription initiation by RNA polymerase II, protein homooligomerization, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA helicase activity, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, single-stranded DNA binding, transcription coactivator activity; CC: nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: P11031
Entrez ID: 20024
|
Does Knockout of Ccdc138 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ccdc138
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccdc138 (coiled-coil domain containing 138)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q0VF22
Entrez ID: 76138
|
Does Knockout of Klrc3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Klrc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klrc3 (killer cell lectin-like receptor subfamily C, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune response-regulating cell surface receptor signaling pathway, immune system process, innate immune response, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell activation, regulation of natural killer cell mediated cytotoxicity, stimulatory C-type lectin receptor signaling pathway; MF: MHC class I protein complex binding, MHC class Ib receptor activity, carbohydrate binding, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: DAP12 interactions, DAP12 signaling, Immune System, Innate Immune System
UniProt: A0A0N4SV83, Q9QXN7, L7N477
Entrez ID: 58179
|
Does Knockout of Tmed2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Tmed2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmed2 (transmembrane p24 trafficking protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, PERK-mediated unfolded protein response, allantois development, branching involved in labyrinthine layer morphogenesis, chorion development, dorsal/ventral neural tube patterning, embryonic morphogenesis, embryonic placenta development, endoplasmic reticulum membrane organization, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, heart looping, in utero embryonic development, inflammatory response, intracellular protein localization, intracellular protein transport, labyrinthine layer blood vessel development, maintenance of protein localization in organelle, maternal placenta development, multicellular organism growth, negative regulation of GTPase activity, negative regulation of protein localization to plasma membrane, negative regulation of smoothened signaling pathway, neural tube closure, positive regulation of gene expression, post-anal tail morphogenesis, protein localization to plasma membrane, protein secretion, protein transport, regulation of SREBP signaling pathway, somite rostral/caudal axis specification, somitogenesis, vesicle-mediated transport; MF: frizzled binding, protein binding, smoothened binding; CC: COPI-coated vesicle, COPI-coated vesicle membrane, COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi cisterna membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, zymogen granule membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, Signal Transduction, Signaling by NOTCH, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9R0Q3
Entrez ID: 56334
|
Does Knockout of Vmn1r33 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Vmn1r33
|
phagocytosis
|
macrophage
|
Gene: Vmn1r33 (vomeronasal 1 receptor 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2E0
Entrez ID: 171187
|
Does Knockout of Snrpa1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Snrpa1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Snrpa1 (small nuclear ribonucleoprotein polypeptide A')
Type: protein-coding
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spermatogenesis; MF: RNA binding, U2 snRNA binding; CC: U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nuclear body, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P57784
Entrez ID: 68981
|
Does Knockout of Tex47 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tex47
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tex47 (testis expressed 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D5W8
Entrez ID: 70920
|
Does Knockout of Pax4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Pax4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pax4 (paired box 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, brain development, cell differentiation, circadian rhythm, forebrain development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial cell differentiation, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of transcription by RNA polymerase II, response to cAMP, response to xenobiotic stimulus, retina development in camera-type eye, sensory organ development, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleus, transcription regulator complex
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P32115
Entrez ID: 18506
|
Does Knockout of Wipi1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Wipi1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Wipi1 (WD repeat domain, phosphoinositide interacting 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, cellular response to starvation, glycophagy, nucleophagy, pexophagy, positive regulation of autophagosome assembly, protein localization to phagophore assembly site, vesicle targeting, trans-Golgi to endosome; MF: lipid binding, nuclear androgen receptor binding, nuclear estrogen receptor binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: Golgi apparatus, autophagosome membrane, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, endosome membrane, membrane, phagophore assembly site, phagophore assembly site membrane, trans-Golgi network
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Macroautophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q8R3E3
Entrez ID: 52639
|
Does Knockout of Ryr3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Ryr3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ryr3 (ryanodine receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to ATP, cellular response to caffeine, cellular response to calcium ion, cellular response to magnesium ion, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, protein homotetramerization, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, striated muscle contraction, transmembrane transport; MF: calcium channel activity, calcium ion binding, calmodulin binding, intracellularly gated calcium channel activity, monoatomic ion channel activity, ryanodine-sensitive calcium-release channel activity; CC: Z disc, calcium channel complex, junctional membrane complex, membrane, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum
Pathways: Alzheimer disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Circadian entrainment - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: A2AGL3
Entrez ID: 20192
|
Does Knockout of Kcnk12 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Kcnk12
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcnk12 (potassium channel, subfamily K, member 12)
Type: protein-coding
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport; MF: identical protein binding, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein heterodimerization activity; CC: endoplasmic reticulum membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Phase 4 - resting membrane potential
UniProt: Q76M80
Entrez ID: 210741
|
Does Knockout of Irf2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Irf2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Irf2 (interferon regulatory factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, toll-like receptor 3 signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: cytosol, focal adhesion, nucleoplasm, nucleus
Pathways:
UniProt: P23906
Entrez ID: 16363
|
Does Knockout of Csf3r in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Csf3r
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Csf3r (colony stimulating factor 3 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amelogenesis, cell adhesion, cytokine-mediated signaling pathway, neutrophil chemotaxis, regulation of myeloid cell differentiation; MF: cytokine binding, cytokine receptor activity, granulocyte colony-stimulating factor binding, protein binding; CC: endocytic vesicle membrane, external side of plasma membrane, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P40223
Entrez ID: 12986
|
Does Knockout of Pcdhb1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Pcdhb1
|
phagocytosis
|
macrophage
|
Gene: Pcdhb1 (protocadherin beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91Y08
Entrez ID: 93872
|
Does Knockout of Srpx2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Srpx2
|
cell cycle progression
|
breast epithelium
|
Gene: Srpx2 (sushi-repeat-containing protein, X-linked 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell motility, cell-cell adhesion, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of synapse assembly, regulation of phosphorylation, regulation of synapse assembly, vocalization behavior; MF: extracellular matrix structural constituent, hepatocyte growth factor binding, identical protein binding, signaling receptor binding; CC: cell surface, cytoplasm, excitatory synapse, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, synapse, synaptic membrane
Pathways:
UniProt: Q8R054
Entrez ID: 68792
|
Does Knockout of Prr23a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Prr23a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Prr23a2 (proline rich 23A, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3YWX5
Entrez ID: 623186
|
Does Knockout of Mfsd4b2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Mfsd4b2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mfsd4b2 (major facilitator superfamily domain containing 4B2)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 72045
|
Does Knockout of Slc2a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Slc2a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc2a1 (solute carrier family 2 (facilitated glucose transporter), member 1)
Type: protein-coding
Summary: Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and fucose transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Acts upstream of or within GDP-L-fucose salvage and cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; nucleus; and photoreceptor inner segment. Is active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study glucose transporter type 1 deficiency syndrome 1. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucose import, D-glucose import across plasma membrane, D-glucose transmembrane transport, GDP-L-fucose salvage, cellular hyperosmotic response, cellular response to glucose starvation, cellular response to mechanical stimulus, central nervous system development, cerebral cortex development, dehydroascorbic acid transport, female pregnancy, fucose transmembrane transport, long-chain fatty acid import across plasma membrane, photoreceptor cell maintenance, protein-containing complex assembly, response to Thyroglobulin triiodothyronine, response to hypoxia, response to insulin, transmembrane transport, transport across blood-brain barrier, xenobiotic transport; MF: D-glucose transmembrane transporter activity, dehydroascorbic acid transmembrane transporter activity, fucose transmembrane transporter activity, identical protein binding, kinase binding, long-chain fatty acid transmembrane transporter activity, protein binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: Golgi membrane, Z disc, apical plasma membrane, basolateral plasma membrane, caveola, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytosol, female germ cell nucleus, female pronucleus, glucose transporter complex, intercalated disc, membrane, membrane raft, midbody, photoreceptor inner segment, plasma membrane, presynapse, sarcolemma, synapse, vesicle
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Cellular hexose transport, Central carbon metabolism in cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Lactose synthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pathways in cancer - Mus musculus (mouse), Regulation of insulin secretion, Renal cell carcinoma - Mus musculus (mouse), SLC-mediated transmembrane transport, Thyroid hormone signaling pathway - Mus musculus (mouse), Transport of small molecules, Vitamin C (ascorbate) metabolism
UniProt: P17809
Entrez ID: 20525
|
Does Knockout of Pms2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Pms2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pms2 (PMS1 homolog2, mismatch repair system component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, meiotic cell cycle, mismatch repair, positive regulation of isotype switching to IgA isotypes, positive regulation of isotype switching to IgG isotypes, response to xenobiotic stimulus, somatic hypermutation of immunoglobulin genes, somatic recombination of immunoglobulin gene segments; MF: ATP binding, ATP hydrolysis activity, ATP-dependent DNA damage sensor activity, DNA binding, MutSalpha complex binding, endonuclease activity, hydrolase activity, mismatched DNA binding, nuclease activity, nucleotide binding, single base insertion or deletion binding, single-stranded DNA binding; CC: MutLalpha complex, cytosol, mismatch repair complex, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse)
UniProt: P54279
Entrez ID: 18861
|
Does Knockout of Olfm4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Olfm4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Olfm4 (olfactomedin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, negative regulation of canonical NF-kappaB signal transduction, negative regulation of immune response, positive regulation of substrate adhesion-dependent cell spreading, signal transduction; MF: cadherin binding, protein binding, structural molecule activity; CC: cytosol, extracellular region, extracellular space, intercellular bridge, mitochondrion, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, specific granule
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q3UZZ4
Entrez ID: 380924
|
Does Knockout of Cenpc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cenpc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cenpc1 (centromere protein C1)
Type: protein-coding
Summary: This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, mitotic cell cycle, spindle attachment to meiosis I kinetochore; MF: DNA binding, centromeric DNA binding, identical protein binding, protein binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, inner kinetochore, kinetochore, midbody, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P49452
Entrez ID: 12617
|
Does Knockout of Sfswap in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sfswap
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sfswap (splicing factor SWAP)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, alternative mRNA splicing, via spliceosome, mRNA 5'-splice site recognition, mRNA processing, negative regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding
Pathways:
UniProt: Q3USH5
Entrez ID: 231769
|
Does Knockout of Fzd7 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Fzd7
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fzd7 (frizzled class receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell differentiation in thymus, Wnt signaling pathway, canonical Wnt signaling pathway, cell surface receptor signaling pathway, mesenchymal to epithelial transition, negative regulation of cardiac muscle cell differentiation, negative regulation of cell-substrate adhesion, negative regulation of ectodermal cell fate specification, non-canonical Wnt signaling pathway, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of phosphorylation, regulation of DNA-templated transcription, regulation of canonical Wnt signaling pathway, signal transduction, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, somatic stem cell division, stem cell population maintenance, substrate adhesion-dependent cell spreading; MF: G protein-coupled receptor activity, PDZ domain binding, Wnt receptor activity, Wnt-protein binding, frizzled binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, transmembrane signaling receptor activity; CC: endosome, endosome membrane, membrane, plasma membrane, recycling endosome membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Asymmetric localization of PCP proteins, Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q61090
Entrez ID: 14369
|
Does Knockout of Xkrx in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Xkrx
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Xkrx (X-linked Kx blood group related, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q5GH68
Entrez ID: 331524
|
Does Knockout of Atg9b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Atg9b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atg9b (autophagy related 9B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, bone morphogenesis, lipid transport, mitophagy, piecemeal microautophagy of the nucleus, plasma membrane phospholipid scrambling, programmed necrotic cell death, protein localization to phagophore assembly site, reticulophagy; MF: molecular_function, phospholipid scramblase activity; CC: Golgi membrane, autophagosome, cytoplasm, endoplasmic reticulum membrane, membrane, phagophore assembly site, phagophore assembly site membrane, recycling endosome membrane, trans-Golgi network
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Macroautophagy, Mitophagy - animal - Mus musculus (mouse)
UniProt: Q6EBV9
Entrez ID: 213948
|
Does Knockout of Adgrl4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Adgrl4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adgrl4 (adhesion G protein-coupled receptor L4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, positive regulation of synapse assembly, protein-containing complex assembly, signal transduction; MF: G protein-coupled receptor activity, calcium ion binding, transmembrane signaling receptor activity; CC: cytoplasmic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q923X1
Entrez ID: 170757
|
Does Knockout of Wfdc5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Wfdc5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wfdc5 (WAP four-disulfide core domain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: F6TTH9, Q4KXB6
Entrez ID: 209232
|
Does Knockout of Sp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Sp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sp1 (trans-acting transcription factor 1)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to hydroperoxide. Acts upstream of or within several processes, including embryo development; hemopoiesis; and mRNA transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; epithelium; eye; and genitourinary system. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to insulin stimulus, definitive hemopoiesis, embryonic camera-type eye morphogenesis, embryonic placenta development, embryonic process involved in female pregnancy, embryonic skeletal system development, enucleate erythrocyte differentiation, gene expression, host-mediated activation of viral transcription, in utero embryonic development, liver development, lung development, mRNA transcription by RNA polymerase II, megakaryocyte differentiation, myeloid progenitor cell differentiation, neuron differentiation, ossification, positive regulation of DNA-templated transcription, positive regulation of amyloid-beta formation, positive regulation of angiogenesis, positive regulation of apoptotic signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of gene expression, positive regulation of hydrogen sulfide biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to hydroperoxide, retinoic acid catabolic process, retinoic acid receptor signaling pathway, rhythmic process, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, bHLH transcription factor binding, cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, histone acetyltransferase binding, histone deacetylase binding, identical protein binding, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromatin, cytoplasm, euchromatin, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription repressor complex
Pathways: Adherens junctions interactions, Breast cancer - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Choline metabolism in cancer - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Human cytomegalovirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes, Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Spinocerebellar ataxia - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: O89090
Entrez ID: 20683
|
Does Knockout of Mir3061 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mir3061
|
cell cycle progression
|
breast epithelium
|
Gene: Mir3061 (microRNA 3061)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100526467
|
Does Knockout of Zbtb17 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zbtb17
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zbtb17 (zinc finger and BTB domain containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, ectoderm development, gastrulation with mouth forming second, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, metal ion binding, protein binding, transcription coactivator binding, zinc ion binding; CC: nucleus, protein-DNA complex, protein-containing complex
Pathways: Cell cycle - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q60821
Entrez ID: 22642
|
Does Knockout of Pars2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Pars2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pars2 (prolyl-tRNA synthetase (mitochondrial)(putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8CFI5
Entrez ID: 230577
|
Does Knockout of Gcsam in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gcsam
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gcsam (germinal center associated, signaling and motility)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of lymphocyte migration, regulation of B cell receptor signaling pathway, regulation of lymphocyte migration; MF: actin binding, myosin II binding, protein kinase binding; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q6RFH4
Entrez ID: 14525
|
Does Knockout of Gas8 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gas8
|
response to virus
|
Microglial Cell Line
|
Gene: Gas8 (growth arrest specific 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, brain development, cell motility, cilium movement involved in cell motility, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, flagellated sperm motility, intracellular protein localization, microtubule cytoskeleton organization, positive regulation of protein localization to cilium, positive regulation of smoothened signaling pathway; MF: microtubule binding, protein binding, small GTPase binding; CC: 9+2 motile cilium, Golgi apparatus, axoneme, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, extracellular region, glial cell projection, microtubule, microtubule cytoskeleton, motile cilium, plasma membrane, sperm flagellum
Pathways: Activation of SMO, Hedgehog 'on' state, Signal Transduction, Signaling by Hedgehog
UniProt: Q60779
Entrez ID: 104346
|
Does Knockout of Pfas in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Pfas
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, anterior head development, glutamine metabolic process, purine nucleotide biosynthetic process, response to xenobiotic stimulus; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, phosphoribosylformylglycinamidine synthase activity; CC: cytoplasm
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis
UniProt: Q5SUR0
Entrez ID: 237823
|
Does Knockout of Ppcs in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ppcs
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppcs (phosphopantothenoylcysteine synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA biosynthetic process, coenzyme A biosynthetic process, heart process; MF: ATP binding, identical protein binding, ligase activity, nucleotide binding, phosphopantothenate--cysteine ligase activity, protein homodimerization activity; CC: cytoplasm, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q8VDG5
Entrez ID: 106564
|
Does Knockout of C1qtnf6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
C1qtnf6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: C1qtnf6 (C1q and tumor necrosis factor related protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, cytoplasm, extracellular region, extracellular space, protein-containing complex
Pathways:
UniProt: Q6IR41
Entrez ID: 72709
|
Does Knockout of Zfp661 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Zfp661
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp661 (zinc finger protein 661)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BIQ3
Entrez ID: 72180
|
Does Knockout of Ubac1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ubac1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ubac1 (ubiquitin associated domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein maturation, protein ubiquitination; MF: molecular_function, polyubiquitin modification-dependent protein binding, proteasome binding; CC: Golgi apparatus, cytoplasm, cytosol, plasma membrane, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8VDI7
Entrez ID: 98766
|
Does Knockout of Ace in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ace
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ace (angiotensin I converting enzyme)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta metabolic process, angiogenesis involved in coronary vascular morphogenesis, angiotensin maturation, angiotensin-activated signaling pathway, animal organ regeneration, arachidonate secretion, bradykinin catabolic process, cell proliferation in bone marrow, eating behavior, embryo development ending in birth or egg hatching, heart contraction, hormone catabolic process, hormone metabolic process, kidney development, lung alveolus development, maintenance of blood vessel diameter homeostasis by renin-angiotensin, male gonad development, negative regulation of D-glucose import, negative regulation of calcium ion import, negative regulation of gap junction assembly, negative regulation of gene expression, neutrophil mediated immunity, peptide catabolic process, peptide metabolic process, positive regulation of apoptotic process, positive regulation of blood pressure, positive regulation of neurogenesis, positive regulation of systemic arterial blood pressure, positive regulation of vasoconstriction, post-transcriptional regulation of gene expression, proteolysis, regulation of angiotensin metabolic process, regulation of blood circulation, regulation of blood pressure, regulation of heart rate by cardiac conduction, regulation of hematopoietic stem cell proliferation, regulation of smooth muscle cell migration, regulation of synaptic plasticity, regulation of systemic arterial blood pressure by renin-angiotensin, response to lipopolysaccharide, spermatogenesis, substance P catabolic process, vasoconstriction, vasodilation; MF: actin binding, bradykinin receptor binding, calmodulin binding, carboxypeptidase activity, chloride ion binding, endopeptidase activity, exopeptidase activity, heterocyclic compound binding, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallodipeptidase activity, metalloendopeptidase activity, metallopeptidase activity, mitogen-activated protein kinase binding, mitogen-activated protein kinase kinase binding, peptidase activity, peptidyl-dipeptidase activity, protein binding, tripeptidyl-peptidase activity, zinc ion binding; CC: basal plasma membrane, brush border membrane, cytoplasm, endosome, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, lysosome, membrane, plasma membrane, sperm midpiece, vesicle
Pathways: Chagas disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, Renin secretion - Mus musculus (mouse), Renin-angiotensin system - Mus musculus (mouse)
UniProt: P09470
Entrez ID: 11421
|
Does Knockout of Ccl3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ccl3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ccl3 (C-C motif chemokine ligand 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell chemotaxis, antimicrobial humoral immune response mediated by antimicrobial peptide, astrocyte cell migration, calcium ion transport, calcium-mediated signaling, cell activation, cell chemotaxis, cell-cell signaling, chemokine-mediated signaling pathway, chemotaxis, cytoskeleton organization, eosinophil chemotaxis, eosinophil degranulation, exocytosis, granulocyte chemotaxis, host-mediated suppression of viral transcription, immune response, inflammatory response, intracellular calcium ion homeostasis, leukocyte chemotaxis, lymphocyte chemotaxis, macrophage chemotaxis, monocyte chemotaxis, negative regulation of gene expression, negative regulation of osteoclast differentiation, neutrophil chemotaxis, osteoblast differentiation, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of calcium ion transport, positive regulation of calcium-mediated signaling, positive regulation of cell migration, positive regulation of cytosolic calcium ion concentration, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of natural killer cell chemotaxis, positive regulation of neuron apoptotic process, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, regulation of cell shape, regulation of programmed cell death, regulation of sensory perception of pain, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to cholesterol, response to toxic substance, response to xenobiotic stimulus, signaling; MF: CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, chemoattractant activity, chemokine activity, cytokine activity, identical protein binding, kinase activity, phospholipase activator activity, protein binding, protein kinase activity; CC: cytoplasm, cytosol, extracellular region, extracellular space
Pathways: Chagas disease - Mus musculus (mouse), Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), GPCR ligand binding, Human cytomegalovirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Peptide ligand-binding receptors, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Toll-like receptor signaling pathway - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P10855
Entrez ID: 20302
|
Does Knockout of Idi1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Idi1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Idi1 (isopentenyl-diphosphate delta isomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, dimethylallyl diphosphate biosynthetic process, isopentenyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid metabolic process, response to stilbenoid, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: isomerase activity, isopentenyl-diphosphate delta-isomerase activity, magnesium ion binding, manganese ion binding, metal ion binding; CC: cytoplasm, cytosol, mitochondrion, peroxisome
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Terpenoid backbone biosynthesis - Mus musculus (mouse), mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: P58044
Entrez ID: 319554
|
Does Knockout of Ap5m1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ap5m1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ap5m1 (adaptor-related protein complex 5, mu 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal transport, protein transport, vesicle-mediated transport; CC: AP-5 adaptor complex, AP-type membrane coat adaptor complex, cytoplasm, cytosol, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q8BJ63
Entrez ID: 74385
|
Does Knockout of Fbxo25 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fbxo25
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fbxo25 (F-box protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: actin binding, protein binding; CC: SCF ubiquitin ligase complex, cytoplasm, nucleus
Pathways: FoxO signaling pathway - Mus musculus (mouse)
UniProt: Q9D2Y6
Entrez ID: 66822
|
Does Knockout of Myl10 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Myl10
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Myl10 (myosin, light chain 10, regulatory)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, metal ion binding, protein binding; CC: cytoplasm, mitochondrion
Pathways: Focal adhesion - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Muscle contraction, Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Smooth Muscle Contraction
UniProt: Q62082
Entrez ID: 59310
|
Does Knockout of Babam1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,537
|
Knockout
|
Babam1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Babam1 (BRISC and BRCA1 A complex member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cell division, chromatin organization, double-strand break repair, hematopoietic stem cell proliferation, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: identical protein binding, molecular_function; CC: BRCA1-A complex, BRISC complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q3UI43
Entrez ID: 68251
|
Does Knockout of Acsbg2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Acsbg2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Acsbg2 (acyl-CoA synthetase bubblegum family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, spermatogenesis; MF: ATP binding, arachidonate-CoA ligase activity, fatty acyl-CoA hydrolase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding; CC: cytoplasm, cytosol, membrane, mitochondrion
Pathways: γ-linolenate biosynthesis II (animals), Adipocytokine signaling pathway - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid activation
UniProt: Q2XU92
Entrez ID: 328845
|
Does Knockout of Eef2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Eef2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eef2 (eukaryotic translation elongation factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, glial cell proliferation, hematopoietic progenitor cell differentiation, positive regulation of cytoplasmic translation, positive regulation of translation, response to endoplasmic reticulum stress, response to estradiol, response to ethanol, response to folic acid, response to hydrogen peroxide, response to ischemia, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal muscle contraction, translation, translation at postsynapse, translational elongation; MF: 5S rRNA binding, GTP binding, GTPase activity, RNA binding, actin filament binding, hydrolase activity, lncRNA binding, nucleotide binding, p53 binding, protein binding, protein kinase binding, ribosome binding, translation elongation factor activity; CC: aggresome, cytoplasm, cytosol, glutamatergic synapse, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Eukaryotic Translation Elongation, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Oxytocin signaling pathway - Mus musculus (mouse), Peptide chain elongation, Post-translational protein modification, Protein methylation, Synthesis of diphthamide-EEF2, Translation
UniProt: P58252
Entrez ID: 13629
|
Does Knockout of Tnpo1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Tnpo1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tnpo1 (transportin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, small GTPase binding; CC: cytoplasm, nuclear lumen, nucleolus, nucleoplasm, nucleus
Pathways: Cilium Assembly, Intraflagellar transport, Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Organelle biogenesis and maintenance, Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
UniProt: Q8BFY9
Entrez ID: 238799
|
Does Knockout of Mcmbp in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Mcmbp
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mcmbp (minichromosome maintenance complex binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, cell division, sister chromatid cohesion; MF: chromatin binding; CC: MCM complex, cell junction, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8R3C0
Entrez ID: 210711
|
Does Knockout of Podxl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Podxl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Podxl2 (podocalyxin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, leukocyte tethering or rolling; CC: membrane, plasma membrane
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Metabolism, Phase II - Conjugation of compounds
UniProt: Q8CAE9
Entrez ID: 319655
|
Does Knockout of Thap1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Thap1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Thap1 (THAP domain containing, apoptosis associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, endothelial cell proliferation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein homodimerization activity, sequence-specific DNA binding, zinc ion binding; CC: PML body, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q8CHW1
Entrez ID: 73754
|
Does Knockout of Sgpp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Sgpp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sgpp1 (sphingosine-1-phosphate phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER to Golgi ceramide transport, extrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway, lipid metabolic process, phospholipid dephosphorylation, regulation of epidermis development, regulation of keratinocyte differentiation, sphinganine-1-phosphate metabolic process, sphingolipid metabolic process, sphingosine metabolic process; MF: dihydrosphingosine-1-phosphate phosphatase activity, hydrolase activity, sphingosine-1-phosphate phosphatase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q9JI99
Entrez ID: 81535
|
Does Knockout of Cdk7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Cdk7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cdk7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: Basal transcription factors - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, G1 Phase, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, mRNA Capping
UniProt: Q03147
Entrez ID: 12572
|
Does Knockout of Hnrnph1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Hnrnph1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Hnrnph1 (heterogeneous nuclear ribonucleoprotein H1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within cellular response to interleukin-7. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm and postsynaptic density. Is expressed in several structures, including brain; gut; liver; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in Sjogren's syndrome. Orthologous to human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, cellular response to interleukin-7, mRNA processing, regulation of RNA splicing; MF: RNA binding, enzyme binding, identical protein binding, nucleic acid binding, protein binding; CC: catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O35737
Entrez ID: 59013
|
Does Knockout of Ppil2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ppil2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, protein folding, protein localization to plasma membrane, protein polyubiquitination, protein ubiquitination; MF: peptidyl-prolyl cis-trans isomerase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: catalytic step 2 spliceosome, cytoplasm, nucleoplasm, nucleus, plasma membrane, spliceosomal complex
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ubiquitin mediated proteolysis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D787
Entrez ID: 66053
|
Does Knockout of Coa4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Coa4
|
cell cycle progression
|
breast epithelium
|
Gene: Coa4 (cytochrome c oxidase assembly factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial intermembrane space, mitochondrion
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q8BT51
Entrez ID: 68185
|
Does Knockout of Tet1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Tet1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tet1 (tet methylcytosine dioxygenase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to reactive oxygen species, chromatin organization, chromatin remodeling, dendrite morphogenesis, epigenetic programing of male pronucleus, epigenetic regulation of gene expression, inner cell mass cell differentiation, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of macromolecule biosynthetic process, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, protein O-linked glycosylation, regulation of gene expression, stem cell population maintenance; MF: 2-oxoglutarate-dependent dioxygenase activity, DNA 5-methylcytosine dioxygenase activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, dioxygenase activity, iron ion binding, metal ion binding, methyl-CpG binding, oxidoreductase activity, protein binding, zinc ion binding; CC: Sin3-type complex, chromosome, nucleoplasm, nucleus
Pathways:
UniProt: Q3URK3
Entrez ID: 52463
|
Does Knockout of Gipr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gipr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gipr (gastric inhibitory polypeptide receptor)
Type: protein-coding
Summary: Enables gastric inhibitory peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of insulin secretion. Acts upstream of or within endocrine pancreas development. Is active in plasma membrane. Is expressed in cortical plate; foregut-midgut junction; neck; and thyroid gland. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, desensitization of G protein-coupled receptor signaling pathway, endocrine pancreas development, gastric inhibitory peptide signaling pathway, neuropeptide signaling pathway, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, response to axon injury, response to calcium ion, response to fatty acid, response to glucose, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, gastric inhibitory peptide receptor activity, glucagon family peptide binding, peptide hormone binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-type ligand receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q0P543
Entrez ID: 381853
|
Does Knockout of Syne2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Syne2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Syne2 (spectrin repeat containing, nuclear envelope 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centrosome localization, establishment or maintenance of cell polarity, fibroblast migration, nuclear envelope organization, nuclear migration, nuclear migration along microfilament, nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration, positive regulation of cell migration, protein localization to nucleus, regulation of cilium assembly; MF: actin binding, cytoskeleton-nuclear membrane anchor activity, protein binding; CC: Z disc, cilium, cytoplasm, cytoskeleton, fibrillar center, filopodium membrane, focal adhesion, intermediate filament cytoskeleton, lamellipodium membrane, meiotic nuclear membrane microtubule tethering complex, membrane, mitochondrion, myofibril, nuclear envelope, nuclear lumen, nuclear membrane, nuclear outer membrane, nucleoplasm, nucleus, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: Q6ZWQ0
Entrez ID: 319565
|
Does Knockout of Ino80 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,525
|
Knockout
|
Ino80
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ino80 (INO80 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response to ionizing radiation, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, mitotic sister chromatid segregation, positive regulation of DNA metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, spindle assembly, telomere maintenance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, actin binding, alpha-tubulin binding, histone binding, hydrolase activity, nucleotide binding; CC: Ino80 complex, chromosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear body, nucleoplasm, nucleus, spindle
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q6ZPV2
Entrez ID: 68142
|
Does Knockout of Mafb in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mafb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mafb (MAF bZIP transcription factor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, abducens nerve formation, brain segmentation, cornified envelope assembly, gene expression, in utero embryonic development, inner ear morphogenesis, keratinocyte differentiation, negative regulation of erythrocyte differentiation, negative regulation of osteoclast differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, protein processing, regulation of DNA-templated transcription, regulation of myeloid cell differentiation, regulation of transcription by RNA polymerase II, respiratory gaseous exchange by respiratory system, response to nutrient, rhombomere 5 development, rhombomere 6 development, segment specification, thymus development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: P54841
Entrez ID: 16658
|
Does Knockout of Nxnl2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nxnl2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nxnl2 (nucleoredoxin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: photoreceptor cell maintenance, sensory perception, sensory perception of smell, visual perception
Pathways:
UniProt: Q9D531
Entrez ID: 75124
|
Does Knockout of Raet1a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Raet1a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Raet1a (retinoic acid early transcript 1, alpha)
Type: protein-coding
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within cellular response to exogenous dsRNA; cellular response to lipopolysaccharide; and defense response to bacterium. Located in plasma membrane. Is expressed in several structures, including branchial arch; heart; liver; placenta; and spleen. Orthologous to human RAET1E (retinoic acid early transcript 1E); RAET1G (retinoic acid early transcript 1G); and RAET1L (retinoic acid early transcript 1L). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, cellular response to exogenous dsRNA, cellular response to lipopolysaccharide, defense response to bacterium, immune response, positive regulation of T cell mediated cytotoxicity; MF: natural killer cell lectin-like receptor binding; CC: cell surface, external side of plasma membrane, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: O08602
Entrez ID: 19368
|
Does Knockout of Med8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Med8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Med8 (mediator complex subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways:
UniProt: Q9D7W5
Entrez ID: 80509
|
Does Knockout of Mettl27 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Mettl27
|
cell proliferation
|
Regulatory T cell
|
Gene: Mettl27 (methyltransferase like 27)
Type: protein-coding
Summary: Orthologous to human METTL27 (methyltransferase like 27). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8BGM4, Q8BY07, F6RCZ2, A0A0J9YUG5, D3Z271
Entrez ID: 79565
|
Does Knockout of L3mbtl3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
L3mbtl3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: L3mbtl3 (L3MBTL3 histone methyl-lysine binding protein)
Type: protein-coding
Summary: Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Involved in regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Located in nucleus. Is expressed in retina. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, erythrocyte maturation, granulocyte differentiation, macrophage differentiation, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription initiation-coupled chromatin remodeling, positive regulation of ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of ubiquitin-dependent protein catabolic process; MF: chromatin binding, histone binding, identical protein binding, metal ion binding, methylation-dependent protein binding, protein binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BLB7
Entrez ID: 237339
|
Does Knockout of Mrps31 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mrps31
|
cell cycle progression
|
breast epithelium
|
Gene: Mrps31 (mitochondrial ribosomal protein S31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein domain specific binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q61733
Entrez ID: 57312
|
Does Knockout of Eme2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Eme2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Eme2 (essential meiotic structure-specific endonuclease subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair, mitotic intra-S DNA damage checkpoint signaling, replication fork processing, resolution of meiotic recombination intermediates, telomere maintenance; MF: DNA binding, DNA endonuclease activity, crossover junction DNA endonuclease activity, enzyme-substrate adaptor activity, nuclease activity; CC: Holliday junction resolvase complex, chromosome, telomeric region, endodeoxyribonuclease complex, nuclear replication fork, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q56A04
Entrez ID: 193838
|
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