prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Zdhhc14 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Zdhhc14
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zdhhc14 (zinc finger, DHHC domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptidyl-L-cysteine S-palmitoylation, protein targeting to membrane; MF: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8BQQ1
Entrez ID: 224454
|
Does Knockout of Rhog in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rhog
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rhog (ras homolog family member G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, Rho protein signal transduction, actin cytoskeleton organization, actin filament organization, activation of GTPase activity, cell chemotaxis, cortical cytoskeleton organization, establishment or maintenance of cell polarity, positive regulation of DNA-templated transcription, positive regulation of protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of postsynapse assembly, regulation of ruffle assembly, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytoplasmic vesicle, cytoskeleton, glutamatergic synapse, membrane, plasma membrane, postsynapse
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, Neutrophil degranulation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet activation, signaling and aggregation, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate KTN1, RHOG GTPase cycle, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: P84096
Entrez ID: 56212
|
Does Knockout of Upp2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Upp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Upp2 (uridine phosphorylase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP catabolic process, UMP catabolic process, UMP salvage, dCMP catabolic process, nucleoside metabolic process, nucleotide catabolic process, uridine catabolic process; MF: catalytic activity, deoxyuridine phosphorylase activity, glycosyltransferase activity, identical protein binding, pentosyltransferase activity, transferase activity, uridine phosphorylase activity; CC: cytoplasm, cytosol, type III intermediate filament
Pathways: (deoxy)ribose phosphate degradation, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Nucleotide salvage, Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage, salvage pathways of pyrimidine ribonucleotides
UniProt: Q8CGR7
Entrez ID: 76654
|
Does Knockout of Letm2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Letm2
|
phagocytosis
|
macrophage
|
Gene: Letm2 (leucine zipper-EF-hand containing transmembrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial calcium ion transmembrane transport, mitochondrion organization; MF: molecular_function, ribosome binding, transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q7TNU7
Entrez ID: 270035
|
Does Knockout of Kif1a in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Kif1a
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Kif1a (kinesin family member 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, anterograde dendritic transport, anterograde neuronal dense core vesicle transport, anterograde synaptic vesicle transport, dense core granule cytoskeletal transport, interkinetic nuclear migration, microtubule-based movement, protein transport along microtubule, regulation of dendritic spine development, regulation of dendritic spine morphogenesis, retrograde neuronal dense core vesicle transport, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, identical protein binding, isomerase activity, metal ion binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding; CC: axon, axon cytoplasm, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, dendrite, glutamatergic synapse, kinesin complex, membrane, microtubule, neuron projection, neuronal cell body, neuronal dense core vesicle, neuronal dense core vesicle membrane, perinuclear region of cytoplasm, postsynapse, presynapse, protein-containing complex, synapse, synaptic vesicle
Pathways:
UniProt: A0A087WQE8, Q6TA13, G3UW47, Q3UH16, Q6P5H4, E9Q9G6, E9QAN4, A0A087WRJ3, A0A087WSU7, A0A087WNM0
Entrez ID: 16560
|
Does Knockout of Hsf2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hsf2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hsf2 (heat shock factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: P38533
Entrez ID: 15500
|
Does Knockout of Dimt1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Dimt1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dimt1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of rRNA processing, rRNA methylation, rRNA modification, rRNA processing, ribosomal small subunit biogenesis; MF: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity, RNA binding, methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q9D0D4
Entrez ID: 66254
|
Does Knockout of Rpp25 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rpp25
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rpp25 (ribonuclease P/MRP 25 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: RNA binding, nucleic acid binding, ribonuclease P RNA binding, ribonuclease P activity; CC: centriolar satellite, multimeric ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonuclease MRP complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q91WE3
Entrez ID: 102614
|
Does Knockout of Foxc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Foxc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Foxc1 (forkhead box C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, anatomical structure morphogenesis, angiogenesis, artery morphogenesis, blood vessel development, blood vessel diameter maintenance, blood vessel remodeling, brain development, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell migration, cell population proliferation, cellular response to chemokine, cellular response to epidermal growth factor stimulus, cerebellum development, chemokine-mediated signaling pathway, collagen fibril organization, embryonic heart tube development, endochondral ossification, eye development, germ cell migration, glomerular epithelium development, glycosaminoglycan metabolic process, heart development, heart morphogenesis, in utero embryonic development, kidney development, lacrimal gland development, lymph vessel development, maintenance of lens transparency, mesenchymal cell development, mesenchymal cell differentiation, negative regulation of angiogenesis, negative regulation of apoptotic process involved in outflow tract morphogenesis, negative regulation of lymphangiogenesis, negative regulation of mitotic cell cycle, negative regulation of transcription by RNA polymerase II, neural crest cell development, odontogenesis of dentin-containing tooth, ossification, ovarian follicle development, paraxial mesoderm formation, positive regulation of DNA binding, positive regulation of DNA-templated transcription, positive regulation of core promoter binding, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of hematopoietic stem cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of organ growth, regulation of transcription by RNA polymerase II, skeletal system development, somitogenesis, ureteric bud development, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway, ventricular cardiac muscle tissue morphogenesis; MF: DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: cytosol, heterochromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q61572
Entrez ID: 17300
|
Does Knockout of Ostm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ostm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ostm1 (osteopetrosis associated transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: osteoclast differentiation, transepithelial chloride transport; CC: chloride channel complex, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BGT0
Entrez ID: 14628
|
Does Knockout of Ccdc93 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ccdc93
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc93 (coiled-coil domain containing 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, endocytic recycling, protein transport; CC: early endosome, endosome
Pathways:
UniProt: Q7TQK5
Entrez ID: 70829
|
Does Knockout of Gemin2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Gemin2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gemin2 (gem nuclear organelle associated protein 2)
Type: protein-coding
Summary: This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: RNA splicing, mRNA processing, protein-containing complex assembly, spliceosomal complex assembly, spliceosomal snRNP assembly; CC: Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, snRNP Assembly
UniProt: Q9CQQ4
Entrez ID: 66603
|
Does Knockout of Cyb5r2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Cyb5r2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyb5r2 (cytochrome b5 reductase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, oxidoreductase activity; CC: endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Erythrocytes take up carbon dioxide and release oxygen, O2/CO2 exchange in erythrocytes, Transport of small molecules
UniProt: Q3KNK3
Entrez ID: 320635
|
Does Knockout of Ctcf in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Ctcf
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ctcf (CCCTC-binding factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, centromeric region, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, dense fibrillar component, granular component, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q61164
Entrez ID: 13018
|
Does Knockout of Lpcat2b in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Lpcat2b
|
phagocytosis
|
macrophage
|
Gene: Lpcat2b (lysophosphatidylcholine acyltransferase 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, glycerolipid metabolic process, lipid metabolic process, phospholipid biosynthetic process, phospholipid metabolic process; MF: 1-acylglycerophosphocholine O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, calcium ion binding, lysophosphatidic acid acyltransferase activity, metal ion binding, molecular_function, transferase activity; CC: cellular_component, endoplasmic reticulum, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse)
UniProt: Q9D5U0
Entrez ID: 70902
|
Does Knockout of Vmn1r80 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Vmn1r80
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r80 (vomeronasal 1 receptor 80)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BR91, L7N1Z3
Entrez ID: 171238
|
Does Knockout of Cnfn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cnfn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnfn (cornifelin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, keratinization; CC: cornified envelope, cytoplasm
Pathways:
UniProt: Q6PCW6
Entrez ID: 72383
|
Does Knockout of Ppp1r1a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ppp1r1a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppp1r1a (protein phosphatase 1, regulatory inhibitor subunit 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen metabolic process, intracellular signal transduction, signal transduction; MF: protein binding, protein phosphatase inhibitor activity; CC: cytoplasm, extracellular space
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse)
UniProt: Q9ERT9
Entrez ID: 58200
|
Does Knockout of Itga5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Itga5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Itga5 (integrin alpha 5 (fibronectin receptor alpha))
Type: protein-coding
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: CD40 signaling pathway, angiogenesis, cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cell-substrate adhesion, cell-substrate junction assembly, endodermal cell differentiation, female pregnancy, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, integrin-mediated signaling pathway, leukocyte cell-cell adhesion, memory, negative regulation of anoikis, negative regulation of autophagy, positive regulation of cell migration, positive regulation of cell-substrate adhesion, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial growth factor signaling pathway, regulation of angiogenesis, response to muscle activity, wound healing, spreading of epidermal cells; MF: calcium ion binding, cell adhesion molecule binding, epidermal growth factor receptor binding, integrin binding, metal ion binding, protein binding, signaling receptor activity, signaling receptor binding; CC: Golgi apparatus, anchoring junction, cell junction, cell surface, cell-cell junction, cytoplasmic vesicle, endoplasmic reticulum, external side of plasma membrane, focal adhesion, glutamatergic synapse, integrin alpha5-beta1 complex, integrin complex, membrane, plasma membrane, postsynaptic membrane, ruffle membrane, synapse
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPER1 signaling, Hematopoietic cell lineage - Mus musculus (mouse), Hemostasis, Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, L1CAM interactions, MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Response of endothelial cells to shear stress, Signal Transduction, Signal transduction by L1, Signaling by GPCR, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Yersinia infection - Mus musculus (mouse)
UniProt: P11688
Entrez ID: 16402
|
Does Knockout of D630023F18Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
D630023F18Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: D630023F18Rik (RIKEN cDNA D630023F18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C3M9
Entrez ID: 98303
|
Does Knockout of Zdhhc11 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Zdhhc11
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zdhhc11 (zinc finger, DHHC domain containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, peptidyl-L-cysteine S-palmitoylation, positive regulation of defense response to virus by host, protein targeting to membrane; MF: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, signaling adaptor activity, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endosome, endosome membrane, membrane
Pathways:
UniProt: Q14AK4
Entrez ID: 71164
|
Does Knockout of Inpp5j in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Inpp5j
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Inpp5j (inositol polyphosphate 5-phosphatase J)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of microtubule polymerization, negative regulation of neuron projection development, phosphatidylinositol dephosphorylation; MF: SH3 domain binding, hydrolase activity, inositol trisphosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, inositol-polyphosphate 5-phosphatase activity, phosphatase activity, phosphatidylinositol phosphate 5-phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; CC: cytoplasm, dendritic shaft, growth cone, neuron projection, plasma membrane, ruffle, ruffle membrane
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of IP3 and IP4 in the cytosol, Synthesis of PIPs at the plasma membrane, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: P59644
Entrez ID: 170835
|
Does Knockout of Enpp1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Enpp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1)
Type: protein-coding
Summary: This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, ATP metabolic process, B-1 B cell homeostasis, D-glucose import, T cell differentiation, Wnt signaling pathway, adipose tissue development, adult locomotory behavior, adult walking behavior, animal organ development, aorta development, apoptotic process involved in development, artery development, articular cartilage development, axon regeneration, biomineral tissue development, bone development, bone growth, bone mineralization, bone mineralization involved in bone maturation, bone remodeling, bone resorption, bone trabecula formation, calcium ion homeostasis, cartilage development, cell morphogenesis, cell population proliferation, cellular homeostasis, cellular response to insulin stimulus, cellular response to sodium phosphate, cementum mineralization, central nervous system myelination, coenzyme A catabolic process, collagen-activated signaling pathway, defense response to protozoan, determination of adult lifespan, diphosphate metabolic process, endochondral bone morphogenesis, endochondral ossification, establishment of localization in cell, fat cell differentiation, fat pad development, fatty acid metabolic process, fibroblast growth factor receptor signaling pathway, gene expression, generation of precursor metabolites and energy, glucose homeostasis, glycolytic process, heart development, hematopoietic stem cell migration to bone marrow, hormone metabolic process, immune response, inflammatory response to antigenic stimulus, inhibition of non-skeletal tissue mineralization, inorganic diphosphate transport, intracellular phosphate ion homeostasis, kidney development, leukocyte activation involved in inflammatory response, ligamentous ossification, long-term synaptic potentiation, mRNA transcription by RNA polymerase II, macrophage differentiation, magnesium ion homeostasis, melanocyte differentiation, microglia differentiation, microglial cell migration, middle ear morphogenesis, mitochondrion organization, morphogenesis of an epithelium, mucus secretion, multicellular organism growth, muscle cell cellular homeostasis, negative regulation of D-glucose import, negative regulation of bone mineralization, negative regulation of cell growth, negative regulation of fat cell differentiation, negative regulation of glycogen biosynthetic process, negative regulation of hh target transcription factor activity, negative regulation of insulin receptor signaling pathway, negative regulation of ossification, neuron apoptotic process, nucleoside triphosphate catabolic process, odontogenesis, oligodendrocyte apoptotic process, organic phosphonate metabolic process, ossification, osteoblast differentiation, osteoclast differentiation, phosphate ion homeostasis, phosphate-containing compound metabolic process, plasma cell differentiation, post-embryonic forelimb morphogenesis, protein poly-ADP-ribosylation, regulation of bone mineralization, response to ATP, response to Gram-positive bacterium, response to dietary excess, response to insulin, response to magnesium ion, response to platelet-derived growth factor, response to sodium phosphate, response to vitamin B6, response to wounding, sensory perception of mechanical stimulus, sensory perception of sound, sensory perception of temperature stimulus, skin development, smoothened signaling pathway, spinal cord development, tooth mineralization, vascular associated smooth muscle cell migration, vascular associated smooth muscle cell proliferation, vasculogenesis, vesicle-mediated transport, vitamin D3 metabolic process; MF: 3',5'-cyclic-AMP phosphodiesterase activity, ATP binding, ATP diphosphatase activity, GTP diphosphatase activity, UTP diphosphatase activity, calcium ion binding, coenzyme A diphosphatase activity, cyclic-GMP-AMP hydrolase activity, dinucleotide phosphatase activity, exonuclease activity, hydrolase activity, identical protein binding, insulin receptor binding, metal ion binding, nucleic acid binding, nucleoside triphosphate diphosphatase activity, phosphatase activity, phosphodiesterase I activity, phosphoric diester hydrolase activity, polysaccharide binding, protein homodimerization activity, pyrophosphatase activity, scavenger receptor activity, zinc ion binding; CC: apical dendrite, basal dendrite, basolateral plasma membrane, cell body, cell projection, cell surface, extracellular region, extracellular space, membrane, neuronal cell body, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Pantothenate and CoA biosynthesis - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), Riboflavin metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, riboflavin, FMN and FAD transformations
UniProt: P06802
Entrez ID: 18605
|
Does Knockout of Alox12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,280
|
Knockout
|
Alox12
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Alox12 (arachidonate 12-lipoxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, cellular response to lipid, establishment of skin barrier, fatty acid metabolic process, fatty acid oxidation, hepoxilin biosynthetic process, leukotriene A4 metabolic process, linoleic acid metabolic process, lipid metabolic process, lipid oxidation, lipoxin A4 biosynthetic process, lipoxin B4 biosynthetic process, lipoxygenase pathway, negative regulation of apoptotic process, negative regulation of muscle cell apoptotic process, negative regulation of platelet aggregation, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of endothelial tube morphogenesis, positive regulation of mitochondrial depolarization, positive regulation of reactive oxygen species biosynthetic process, positive regulation of smooth muscle cell proliferation, unsaturated fatty acid metabolic process; MF: arachidonate 12(S)-lipoxygenase activity, arachidonate 15-lipoxygenase activity, dioxygenase activity, hepoxilin-epoxide hydrolase activity, hydrolase activity, iron ion binding, linoleate 13S-lipoxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; CC: cytoplasm, cytosol, membrane, sarcolemma
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biosynthesis of DHA-derived SPMs, Biosynthesis of DPA-derived SPMs, Biosynthesis of DPAn-3 SPMs, Biosynthesis of DPAn-3-derived maresins, Biosynthesis of DPAn-6 SPMs, Biosynthesis of Lipoxins (LX), Biosynthesis of specialized proresolving mediators (SPMs), Fatty acid metabolism, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Serotonergic synapse - Mus musculus (mouse), Synthesis of 12-eicosatetraenoic acid derivatives, Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
UniProt: P39655
Entrez ID: 11684
|
Does Knockout of Defb34 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Defb34
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Defb34 (defensin beta 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response; MF: CCR2 chemokine receptor binding, heparin binding, lipopolysaccharide binding; CC: extracellular region, membrane, microvesicle, nucleus
Pathways:
UniProt: Q7TNV8
Entrez ID: 360211
|
Does Knockout of Spc24 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Spc24
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spc24 (SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling; CC: Ndc80 complex, chromosome, chromosome, centromeric region, kinetochore, nucleolus, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9D083
Entrez ID: 67629
|
Does Knockout of Cenpm in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cenpm
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cenpm (centromere protein M)
Type: protein-coding
Summary: This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: biological_process, chromosome segregation; CC: chromosome, chromosome, centromeric region, cytoplasm, inner kinetochore, kinetochore, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CQA0
Entrez ID: 66570
|
Does Knockout of Safb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Safb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Safb (scaffold attachment factor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen receptor signaling pathway, hormone metabolic process, positive regulation of transcription by RNA polymerase II, regulation of androgen receptor signaling pathway, regulation of growth, regulation of mRNA processing, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, nucleic acid binding, protein binding, sequence-specific DNA binding; CC: midbody, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors
UniProt: D3YXK2
Entrez ID: 224903
|
Does Knockout of Dcp2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Dcp2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dcp2 (decapping mRNA 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA catabolic process, negative regulation of telomere maintenance via telomerase, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA stability, regulation of telomerase RNA localization to Cajal body; MF: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, 5'-3' RNA exonuclease activity, RNA binding, hydrolase activity, manganese ion binding, metal ion binding, telomerase RNA binding; CC: P-body, RISC complex, cell junction, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9CYC6
Entrez ID: 70640
|
Does Knockout of Ranbp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ranbp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ranbp1 (RAN binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleocytoplasmic transport, positive regulation of mitotic centrosome separation, spindle organization; MF: GTPase activator activity; CC: axon cytoplasm, centrosome, cytoplasm, cytosol, nuclear pore, plasma membrane bounded cell projection cytoplasm
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P34022
Entrez ID: 19385
|
Does Knockout of Mir6960 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir6960
|
cell cycle progression
|
breast epithelium
|
Gene: Mir6960 (microRNA 6960)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465579
|
Does Knockout of Jsrp1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Jsrp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Jsrp1 (junctional sarcoplasmic reticulum protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to membrane, skeletal muscle contraction; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: Q3MI48
Entrez ID: 71912
|
Does Knockout of Eftud2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Eftud2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Eftud2 (elongation factor Tu GTP binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: GTP binding, GTPase activity, U5 snRNA binding, nucleotide binding, protein binding; CC: Cajal body, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: O08810
Entrez ID: 20624
|
Does Knockout of Hhla1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Hhla1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hhla1 (HERV-H LTR-associating 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q3TYV2
Entrez ID: 654498
|
Does Knockout of Vmn1r237 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Vmn1r237
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r237 (vomeronasal 1 receptor 237)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R296
Entrez ID: 171234
|
Does Knockout of Shc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Shc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Shc1 (src homology 2 domain-containing transforming protein C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, actin cytoskeleton organization, angiogenesis, cell-cell adhesion, cellular response to growth factor stimulus, defense response to bacterium, epidermal growth factor receptor signaling pathway, heart development, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, intracellular signal transduction, negative regulation of DNA-templated transcription, negative regulation of angiogenesis, negative regulation of apoptotic process, neuron differentiation, neuron projection development, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of cell proliferation in bone marrow, positive regulation of smooth muscle cell proliferation, positive regulation of vasoconstriction, regulation of cell population proliferation, regulation of smooth muscle contraction, regulation of superoxide metabolic process, response to endothelin; MF: ephrin receptor binding, epidermal growth factor binding, epidermal growth factor receptor binding, identical protein binding, insulin receptor binding, insulin-like growth factor receptor binding, neurotrophin TRKA receptor binding, phosphoprotein binding, phosphotyrosine residue binding, protein binding, protein phosphatase 2A binding, protein-containing complex binding, protein-macromolecule adaptor activity, receptor tyrosine kinase binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: Shc-EGFR complex, anchoring junction, cytoplasm, cytosol, endosome membrane, focal adhesion, mitochondrial matrix, mitochondrion, plasma membrane
Pathways: Alcoholism - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse)
UniProt: P98083
Entrez ID: 20416
|
Does Knockout of Tmprss11c in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tmprss11c
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmprss11c (transmembrane protease, serine 11c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis, self proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell projection, dendrite, extracellular region, membrane, perikaryon, plasma membrane
Pathways:
UniProt: Q1JRP2
Entrez ID: 435845
|
Does Knockout of Foxi1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Foxi1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Foxi1 (forkhead box I1)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within inner ear morphogenesis. Predicted to be located in nucleolus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study Pendred Syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to human FOXI1 (forkhead box I1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, inner ear morphogenesis, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q922I5
Entrez ID: 14233
|
Does Knockout of Dhrs9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Dhrs9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dhrs9 (dehydrogenase/reductase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, androgen metabolic process, lipid metabolic process, progesterone metabolic process, retinoic acid biosynthetic process, steroid metabolic process; MF: alcohol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, oxidoreductase activity, testosterone dehydrogenase (NAD+) activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q58NB6
Entrez ID: 241452
|
Does Knockout of Egr2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Egr2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Egr2 (early growth response 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell differentiation, aorta development, brain segmentation, facial nerve structural organization, fat cell differentiation, gene expression, motor neuron axon guidance, myelination, positive regulation of DNA-templated transcription, positive regulation of Schwann cell differentiation, positive regulation of myelination, positive regulation of transcription by RNA polymerase II, protein export from nucleus, protein sumoylation, regulation of DNA-templated transcription, regulation of ossification, regulation of transcription by RNA polymerase II, response to insulin, rhombomere 3 development, rhombomere 3 formation, rhombomere 3 structural organization, rhombomere 5 formation, rhombomere 5 structural organization, rhythmic behavior, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SUMO ligase activity, chromatin binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P08152
Entrez ID: 13654
|
Does Knockout of Phf20l1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Phf20l1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Phf20l1 (PHD finger protein 20-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein catabolic process, regulation of transcription by RNA polymerase II; MF: metal ion binding, methylation-dependent protein binding, molecular_function, zinc ion binding; CC: NSL complex, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q8CCJ9
Entrez ID: 239510
|
Does Knockout of Ifi209 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ifi209
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ifi209 (interferon activated gene 209)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, cellular response to interferon-beta; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BV49
Entrez ID: 236312
|
Does Knockout of Lrrc30 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Lrrc30
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lrrc30 (leucine rich repeat containing 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UV48
Entrez ID: 240131
|
Does Knockout of Gm10413 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Gm10413
|
phagocytosis
|
macrophage
|
Gene: Gm10413 (predicted gene 10413)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9PZN8, Q497R9, L7N2C6
Entrez ID: 100041774
|
Does Knockout of Vapb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Vapb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vapb (vesicle-associated membrane protein, associated protein B and C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle budding, IRE1-mediated unfolded protein response, cholesterol transport, endoplasmic reticulum membrane organization, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum unfolded protein response, endoplasmic reticulum-plasma membrane tethering, host-mediated activation of viral genome replication, host-mediated perturbation of viral RNA genome replication, host-mediated suppression of viral genome replication, intracellular calcium ion homeostasis, negative regulation by virus of viral protein levels in host cell, positive regulation of viral genome replication, response to unfolded protein, suppression of viral release by host, viral release from host cell; MF: FFAT motif binding, beta-tubulin binding, enzyme binding, microtubule binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-membrane adaptor activity; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, plasma membrane, postsynapse, presynapse
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cholesterol metabolism - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q8BH80
Entrez ID: 56491
|
Does Knockout of Sell in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Sell
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sell (selectin, lymphocyte)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, leukocyte migration, leukocyte tethering or rolling, negative regulation of leukocyte tethering or rolling, positive regulation of leukocyte adhesion to arterial endothelial cell, positive regulation of neutrophil chemotaxis, positive regulation of neutrophil mediated cytotoxicity, positive regulation of vascular permeability, regulation of apoptotic process, response to ATP, response to cytokine; MF: calcium ion binding, carbohydrate binding, cell adhesion molecule binding, glycolipid binding, metal ion binding, oligosaccharide binding, protease binding, protein binding, sialic acid binding; CC: cell surface, external side of plasma membrane, extracellular space, membrane, plasma membrane
Pathways: Adaptive Immune System, Cell adhesion molecules - Mus musculus (mouse), Cell surface interactions at the vascular wall, Hemostasis, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Neutrophil degranulation
UniProt: P18337
Entrez ID: 20343
|
Does Knockout of Pmaip1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Pmaip1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, T cell homeostasis, apoptotic process, cellular response to glucose starvation, defense response to virus, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of fibroblast proliferation, negative regulation of mitochondrial membrane potential, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of apoptotic process, positive regulation of establishment of protein localization to mitochondrion, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of fibroblast apoptotic process, positive regulation of glucose metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron apoptotic process, positive regulation of release of cytochrome c from mitochondria, proteasomal protein catabolic process, reactive oxygen species metabolic process, regulation of apoptotic process, regulation of mitochondrial membrane permeability, release of cytochrome c from mitochondria, response to UV, response to X-ray, response to dsRNA; CC: Bcl-2 family protein complex, cytosol, mitochondrion, nucleus
Pathways: Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Apoptosis, Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Colorectal cancer - Mus musculus (mouse), Intrinsic Pathway for Apoptosis, Pathways in cancer - Mus musculus (mouse), Programmed Cell Death, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9JM54
Entrez ID: 58801
|
Does Knockout of 4930550C14Rik in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
4930550C14Rik
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: 4930550C14Rik (RIKEN cDNA 4930550C14 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of mitochondrial fission, negative regulation of protein targeting to mitochondrion; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q9D4W2
Entrez ID: 75311
|
Does Knockout of Fnbp4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Fnbp4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fnbp4 (formin binding protein 4)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FNBP4 (formin binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q6ZQ03
Entrez ID: 55935
|
Does Knockout of Lsr in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Lsr
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lsr (lipolysis stimulated lipoprotein receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial structure maintenance, establishment of blood-brain barrier, establishment of skin barrier, lipoprotein transport, liver development, protein localization to tricellular tight junction, regulation of lipid metabolic process, tricellular tight junction assembly, vesicle-mediated transport; MF: lipoprotein particle receptor activity, low-density lipoprotein particle binding, protein binding; CC: anchoring junction, bicellular tight junction, cell junction, chylomicron, low-density lipoprotein particle, membrane, plasma membrane, tight junction, tricellular tight junction, very-low-density lipoprotein particle
Pathways:
UniProt: Q99KG5
Entrez ID: 54135
|
Does Knockout of Il12rb1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Il12rb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il12rb1 (interleukin 12 receptor, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, cellular response to type II interferon, cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, positive regulation of T-helper 1 type immune response, positive regulation of activated T cell proliferation, positive regulation of cell population proliferation, positive regulation of defense response to virus by host, positive regulation of type II interferon production; MF: coreceptor activity, cytokine binding, cytokine receptor activity, interleukin-12 receptor activity, interleukin-12 receptor binding, interleukin-23 binding, interleukin-23 receptor activity; CC: external side of plasma membrane, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q60837
Entrez ID: 16161
|
Does Knockout of Cdk5 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Cdk5
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cdk5 (cyclin dependent kinase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, Schwann cell development, apoptotic process, associative learning, axonogenesis, behavioral response to cocaine, calcium ion import, cell division, cell migration, cell-matrix adhesion, cellular response to amyloid-beta, central nervous system neuron development, cerebellar cortex development, cerebellar cortex formation, cerebellum development, cerebral cortex development, corpus callosum development, cortical actin cytoskeleton organization, dendrite morphogenesis, establishment of localization in cell, excitatory postsynaptic potential, exocytosis, forebrain development, hippocampus development, intracellular protein transport, layer formation in cerebral cortex, mitochondrion organization, motor neuron axon guidance, negative regulation of DNA-templated transcription, negative regulation of axon extension, negative regulation of calcium ion-dependent exocytosis of neurotransmitter, negative regulation of cell cycle, negative regulation of protein export from nucleus, negative regulation of protein ubiquitination, negative regulation of proteolysis, negative regulation of synaptic plasticity, nervous system development, neuron apoptotic process, neuron differentiation, neuron migration, neuron projection development, neuron projection morphogenesis, nucleocytoplasmic transport, oligodendrocyte differentiation, positive regulation of calcium ion-dependent exocytosis, positive regulation of glial cell apoptotic process, positive regulation of neuron apoptotic process, positive regulation of presynaptic cytosolic calcium concentration, positive regulation of protein targeting to membrane, positive regulation of transport, protein localization to synapse, receptor catabolic process, receptor clustering, regulated exocytosis, regulation of cell cycle, regulation of cell cycle phase transition, regulation of cell migration, regulation of dendritic spine morphogenesis, regulation of postsynaptic membrane potential, regulation of presynaptic cytosolic calcium ion concentration, regulation of protein localization to plasma membrane, regulation of synapse pruning, regulation of synaptic plasticity, regulation of synaptic transmission, glutamatergic, response to cocaine, rhythmic process, sensory perception of pain, skeletal muscle tissue development, synapse assembly, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, synaptic vesicle endocytosis, synaptic vesicle transport, telencephalon development, visual learning; MF: ATP binding, ErbB-2 class receptor binding, ErbB-3 class receptor binding, Hsp90 protein binding, acetylcholine receptor activator activity, cyclin-dependent protein serine/threonine kinase activity, cytoskeletal protein binding, ephrin receptor binding, histone kinase activity, ionotropic glutamate receptor binding, kinase activity, nucleotide binding, p53 binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, signaling receptor inhibitor activity, tau-protein kinase activity, transferase activity; CC: Schaffer collateral - CA1 synapse, axon, cell junction, cell projection, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, dendrite, filopodium, glutamatergic synapse, growth cone, lamellipodium, membrane, microtubule, neuromuscular junction, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic density, presynapse, protein kinase 5 complex, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), CRMPs in Sema3A signaling, Cocaine addiction - Mus musculus (mouse), DARPP-32 events, Developmental Biology, G alpha (i) signalling events, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Nervous system development, Opioid Signalling, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Transcriptional Regulation by TP53
UniProt: P49615
Entrez ID: 12568
|
Does Knockout of Ajap1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ajap1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ajap1 (adherens junction associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of wound healing, regulation of polarized epithelial cell differentiation; MF: beta-catenin binding, protein domain specific binding, protein-containing complex binding; CC: adherens junction, anchoring junction, apical plasma membrane, basolateral plasma membrane, cell surface, cell-cell contact zone, cytoplasmic side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: A2ALI5
Entrez ID: 230959
|
Does Knockout of Zfp459 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Zfp459
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp459 (zinc finger protein 459)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cranial ganglion; dorsal root ganglion; early conceptus; and genitourinary system. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A0A286YDM7, Q8BZ17, A0A286YDX0
Entrez ID: 328274
|
Does Knockout of Ptar1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Ptar1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ptar1 (protein prenyltransferase alpha subunit repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Rab geranylgeranyltransferase activity, prenyltransferase activity, protein prenyltransferase activity
Pathways:
UniProt: Q8C3P5, A0A494B9V8, E9QAB6, A0A494BBC8
Entrez ID: 72351
|
Does Knockout of Akt1 in Microglial Cell Line causally result in response to virus?
| 1
| 2,429
|
Knockout
|
Akt1
|
response to virus
|
Microglial Cell Line
|
Gene: Akt1 (thymoma viral proto-oncogene 1)
Type: protein-coding
Summary: This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: DNA damage response, Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, NLS-bearing protein import into nucleus, PERK-mediated unfolded protein response, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, SREBP-SCAP complex retention in endoplasmic reticulum, TORC1 signaling, activation-induced cell death of T cells, anaphase-promoting complex-dependent catabolic process, apoptotic mitochondrial changes, apoptotic process, behavioral response to pain, cGAS/STING signaling pathway, calcium import into the mitochondrion, cell migration, cell migration involved in sprouting angiogenesis, cell projection organization, cellular hyperosmotic salinity response, cellular response to amino acid starvation, cellular response to calcium ion, cellular response to decreased oxygen levels, cellular response to epidermal growth factor stimulus, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to growth factor stimulus, cellular response to heat, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to mechanical stimulus, cellular response to nerve growth factor stimulus, cellular response to nutrient levels, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to peptide, cellular response to platelet-derived growth factor stimulus, cellular response to prostaglandin E stimulus, cellular response to sorbitol, cellular response to starvation, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, complement receptor mediated signaling pathway, cytoplasmic translation, cytoskeleton organization, endoplasmic reticulum to Golgi vesicle-mediated transport, epidermal growth factor receptor signaling pathway, establishment of protein localization to mitochondrion, execution phase of apoptosis, gene expression, germ cell development, gluconeogenesis, glucose homeostasis, glucose metabolic process, glycogen biosynthetic process, glycogen cell differentiation involved in embryonic placenta development, glycogen metabolic process, inflammatory response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, interleukin-18-mediated signaling pathway, intracellular signal transduction, labyrinthine layer blood vessel development, lipopolysaccharide-mediated signaling pathway, maintenance of protein location in mitochondrion, mammalian oogenesis stage, maternal placenta development, negative regulation of JNK cascade, negative regulation of PERK-mediated unfolded protein response, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cGAS/STING signaling pathway, negative regulation of calcium import into the mitochondrion, negative regulation of cell migration, negative regulation of cell size, negative regulation of cilium assembly, negative regulation of fatty acid beta-oxidation, negative regulation of gene expression, negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of leukocyte cell-cell adhesion, negative regulation of long-chain fatty acid import across plasma membrane, negative regulation of lymphocyte migration, negative regulation of protein localization to lysosome, negative regulation of protein ubiquitination, negative regulation of proteolysis, negative regulation of release of cytochrome c from mitochondria, negative regulation of superoxide anion generation, negative regulation of toll-like receptor signaling pathway, negative regulation of translational initiation, nervous system development, osteoblast differentiation, peripheral nervous system myelin maintenance, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of D-glucose import, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of apoptotic process, positive regulation of blood vessel endothelial cell migration, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cholesterol biosynthetic process, positive regulation of cilium assembly, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of fat cell differentiation, positive regulation of fibroblast migration, positive regulation of gene expression, positive regulation of glucose metabolic process, positive regulation of glycogen biosynthetic process, positive regulation of lipid biosynthetic process, positive regulation of mitochondrial membrane potential, positive regulation of nitric oxide biosynthetic process, positive regulation of organ growth, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein localization to cell surface, positive regulation of protein localization to endoplasmic reticulum, positive regulation of protein localization to nucleus, positive regulation of protein localization to plasma membrane, positive regulation of protein metabolic process, positive regulation of smooth muscle cell proliferation, positive regulation of sodium ion transport, positive regulation of toll-like receptor signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation, positive regulation of vasoconstriction, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K29-linked ubiquitination, protein K6-linked ubiquitination, protein catabolic process, protein import into nucleus, protein localization to cilium, protein localization to endoplasmic reticulum, protein maturation, protein phosphorylation, protein ubiquitination, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell migration, regulation of glycogen biosynthetic process, regulation of myelination, regulation of neuron projection development, regulation of postsynapse organization, regulation of protein localization, regulation of tRNA methylation, regulation of translation, regulation of vesicle-mediated transport, response to UV-A, response to fluid shear stress, response to food, response to growth factor, response to growth hormone, response to heat, response to hormone, response to insulin-like growth factor stimulus, response to muscle activity, response to nutrient levels, response to oxidative stress, sphingosine-1-phosphate receptor signaling pathway, spinal cord development, striated muscle cell differentiation, tRNA (guanine-N7)-methylation, tRNA stabilization, toll-like receptor 4 signaling pathway, translation, translational initiation, tricarboxylic acid metabolic process, ubiquitin-dependent protein catabolic process; MF: 14-3-3 protein binding, ATP binding, GTPase activating protein binding, TORC2 complex binding, calmodulin binding, enzyme binding, identical protein binding, kinase activity, kinase binding, nitric-oxide synthase regulator activity, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, potassium channel activator activity, protein binding, protein homodimerization activity, protein kinase C binding, protein kinase activity, protein kinase binding, protein phosphatase 2A binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase binding, protein serine/threonine kinase inhibitor activity, protein serine/threonine/tyrosine kinase activity, transferase activity; CC: cell-cell junction, ciliary basal body, cilium, cytoplasm, cytosol, dendrite, endoplasmic reticulum, glutamatergic synapse, membrane, microtubule cytoskeleton, mitochondrial intermembrane space, mitochondrion, nucleoplasm, nucleus, plasma membrane, protein-containing complex, spindle, vesicle
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to chemical stress, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Colorectal cancer - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Deactivation of the beta-catenin transactivating complex, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, FLT3 Signaling, FOXO-mediated transcription, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G beta:gamma signalling through PI3Kgamma, G-protein beta:gamma signalling, G1/S Transition, GPCR downstream signalling, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Integrin signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), KEAP1-NFE2L2 pathway, KSRP (KHSRP) binds and destabilizes mRNA, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), MTOR signalling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Membrane Trafficking, Metabolism, Metabolism of RNA, Metabolism of cofactors, Metabolism of nitric oxide: NOS3 activation and regulation, Metabolism of vitamins and cofactors, Mitochondrial unfolded protein response (UPRmt), Mitotic G1 phase and G1/S transition, Negative regulation of NOTCH4 signaling, Negative regulation of the PI3K/AKT network, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAB GEFs exchange GTP for GDP on RABs, RNA Polymerase II Transcription, Rab regulation of trafficking, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of PTEN stability and activity, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of beta-cell development, Regulation of gene expression in beta cells, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of localization of FOXO transcription factors, Regulation of mRNA stability by proteins that bind AU-rich elements, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Response of endothelial cells to shear stress, S Phase, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ERBB2, Signaling by GPCR, Signaling by NOTCH, Signaling by NOTCH4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TCF dependent signaling in response to WNT, TNF signaling pathway - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, Thyroid hormone signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Transcriptional Regulation by TP53, Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), eNOS activation, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P31750
Entrez ID: 11651
|
Does Knockout of Prl8a8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Prl8a8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prl8a8 (prolactin family 8, subfamily a, member 81)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9DAS4
Entrez ID: 74188
|
Does Knockout of Nup54 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Nup54
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nup54 (nucleoporin 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, mRNA transport, nuclear pore organization, nucleocytoplasmic transport, protein localization to nuclear inner membrane, protein targeting, protein transport, regulation of protein import into nucleus; MF: identical protein binding, protein-containing complex binding, structural constituent of nuclear pore; CC: membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleus, protein-containing complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8BTS4
Entrez ID: 269113
|
Does Knockout of Pprc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Pprc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pprc1 (peroxisome proliferative activated receptor, gamma, coactivator-related 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: energy homeostasis, positive regulation of transcription by RNA polymerase II; MF: RNA binding, nucleic acid binding, transcription coactivator activity, transcription coregulator activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q6NZN1
Entrez ID: 226169
|
Does Knockout of Nelfa in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nelfa
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nelfa (negative elongation factor complex member A, Whsc2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription elongation by RNA polymerase II, positive regulation of transcription by RNA polymerase II; MF: chromatin binding, molecular adaptor activity, protein binding; CC: NELF complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8BG30
Entrez ID: 24116
|
Does Knockout of Brca1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Brca1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Brca1 (breast cancer 1, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA strand resection involved in replication fork processing, cellular response to indole-3-methanol, cellular response to ionizing radiation, cellular response to tumor necrosis factor, centrosome cycle, centrosome duplication, chordate embryonic development, chromosome segregation, double-strand break repair, double-strand break repair via homologous recombination, fatty acid biosynthetic process, fatty acid metabolic process, homologous recombination, intrinsic apoptotic signaling pathway in response to DNA damage, lipid metabolic process, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of fatty acid biosynthetic process, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of reactive oxygen species metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of cell cycle, positive regulation of gene expression, positive regulation of protein import into nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, postreplication repair, protein K6-linked ubiquitination, protein autoubiquitination, protein ubiquitination, random inactivation of X chromosome, regulation of DNA damage checkpoint, regulation of DNA repair, regulation of cell cycle, regulation of transcription by RNA polymerase II, response to ionizing radiation, sex-chromosome dosage compensation; MF: DNA binding, RNA binding, RNA polymerase binding, chromatin binding, damaged DNA binding, enzyme binding, identical protein binding, metal ion binding, p53 binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: BRCA1-A complex, BRCA1-B complex, BRCA1-BARD1 complex, BRCA1-C complex, DNA repair complex, XY body, centrosome, chromosome, condensed chromosome, condensed nuclear chromosome, cytoplasm, intracellular organelle lumen, lateral element, male germ cell nucleus, mitochondrial matrix, nuclear body, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ribonucleoprotein complex
Pathways: Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, MicroRNAs in cancer - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), PI3K-Akt signaling pathway - Mus musculus (mouse), Post-translational protein modification, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Transcriptional Regulation by TP53, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P48754
Entrez ID: 12189
|
Does Knockout of Lrr1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Lrr1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lrr1 (leucine rich repeat protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, protein ubiquitination
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: D3YY91
Entrez ID: 69706
|
Does Knockout of Zkscan4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Zkscan4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zkscan4 (zinc finger with KRAB and SCAN domains 4)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human ZKSCAN4 (zinc finger with KRAB and SCAN domains 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: A0A286YD55, Q5SZT6
Entrez ID: 544922
|
Does Knockout of Edf1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Edf1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Edf1 (endothelial differentiation-related factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of DNA-templated transcription; MF: DNA binding, TFIID-class transcription factor complex binding, calmodulin binding, transcription coactivator activity; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9JMG1
Entrez ID: 59022
|
Does Knockout of Isoc2a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Isoc2a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Isoc2a (isochorismatase domain containing 2a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, mitochondrion, nucleus
Pathways:
UniProt: P85094
Entrez ID: 664994
|
Does Knockout of Ddit3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Ddit3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ddit3 (DNA-damage inducible transcript 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, GDF15-GFRAL signaling pathway, HRI-mediated signaling, Wnt signaling pathway, anterior/posterior axis specification, apoptotic process, artery development, blood vessel maturation, calcium ion import, cell redox homeostasis, diaphragm contraction, endoplasmic reticulum unfolded protein response, establishment of protein localization to mitochondrion, gene expression, integrated stress response signaling, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to nitrosative stress, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of cold-induced thermogenesis, negative regulation of determination of dorsal identity, negative regulation of fat cell differentiation, negative regulation of interleukin-17 production, negative regulation of interleukin-4 production, negative regulation of myoblast differentiation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon production, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of autophagy in response to ER overload, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of interleukin-8 production, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell cycle, regulation of transcription by RNA polymerase II, release of sequestered calcium ion into cytosol, response to caloric restriction, response to endoplasmic reticulum stress, response to platelet-derived growth factor, response to starvation, response to unfolded protein, response to wounding, sensory perception of sound, vascular associated smooth muscle cell migration, vascular associated smooth muscle cell proliferation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, identical protein binding, leucine zipper domain binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor activity, transcription regulator activator activity, transcription regulator inhibitor activity; CC: CHOP-ATF3 complex, CHOP-ATF4 complex, CHOP-C/EBP complex, RNA polymerase II transcription regulator complex, cytoplasm, late endosome, nucleoplasm, nucleus, protein-DNA complex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P35639
Entrez ID: 13198
|
Does Knockout of Cdk7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Cdk7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdk7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: Basal transcription factors - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, G1 Phase, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, mRNA Capping
UniProt: Q03147
Entrez ID: 12572
|
Does Knockout of Bicd2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Bicd2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Bicd2 (BICD cargo adaptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centrosome localization, mRNA transport, microtubule anchoring at microtubule organizing center, microtubule-based movement, minus-end-directed organelle transport along microtubule, protein localization to Golgi apparatus, protein transport, regulation of microtubule cytoskeleton organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: cytoskeletal anchor activity, dynactin binding, dynein complex binding, dynein light intermediate chain binding, protein binding, small GTPase binding; CC: Golgi apparatus, annulate lamellae, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, nuclear envelope, nuclear pore, nucleus, plasma membrane
Pathways:
UniProt: Q921C5
Entrez ID: 76895
|
Does Knockout of Tap2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,141
|
Knockout
|
Tap2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP))
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adaptive immune response, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent, antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, cytosol to endoplasmic reticulum transport, immune system process, peptide antigen assembly with MHC class I protein complex, peptide antigen transport, peptide transport, positive regulation of T cell mediated cytotoxicity, positive regulation of antigen processing and presentation of peptide antigen via MHC class I, protection from natural killer cell mediated cytotoxicity, protein transport, protein-containing complex assembly, response to molecule of bacterial origin, transmembrane transport; MF: ABC-type peptide antigen transporter activity, ABC-type peptide transporter activity, ABC-type transporter activity, ADP binding, ATP binding, ATP hydrolysis activity, MHC class I protein binding, MHC class Ib protein binding, MHC protein binding, TAP1 binding, TAP2 binding, identical protein binding, metal ion binding, nucleotide binding, peptide antigen binding, peptide transmembrane transporter activity, protein binding, protein homodimerization activity, protein-containing complex binding, tapasin binding; CC: MHC class I peptide loading complex, TAP complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear speck
Pathways: ABC transporters - Mus musculus (mouse), Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Phagosome - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse)
UniProt: P36371
Entrez ID: 21355
|
Does Knockout of Apoc2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Apoc2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Apoc2 (apolipoprotein C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol efflux, chylomicron remnant clearance, chylomicron remodeling, high-density lipoprotein particle clearance, lipid catabolic process, lipid metabolic process, lipid transport, lipoprotein catabolic process, lipoprotein transport, negative regulation of cholesterol transport, negative regulation of lipid metabolic process, negative regulation of receptor-mediated endocytosis, negative regulation of very-low-density lipoprotein particle clearance, phospholipid efflux, positive regulation of fatty acid biosynthetic process, positive regulation of phospholipid catabolic process, positive regulation of triglyceride catabolic process, positive regulation of very-low-density lipoprotein particle remodeling, triglyceride homeostasis; MF: enzyme activator activity, identical protein binding, lipase inhibitor activity, lipid binding, lipoprotein lipase activator activity, molecular function activator activity, phospholipase activator activity, phospholipase binding; CC: chylomicron, cytosol, extracellular region, extracellular space, high-density lipoprotein particle, intermediate-density lipoprotein particle, low-density lipoprotein particle, spherical high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Cholesterol metabolism - Mus musculus (mouse), Chylomicron assembly, Chylomicron remodeling, HDL remodeling, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Retinoid metabolism and transport, Sensory Perception, Transport of small molecules, Visual phototransduction
UniProt: Q05020
Entrez ID: 11813
|
Does Knockout of Zc2hc1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Zc2hc1b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zc2hc1b (zinc finger, C2HC-type containing 1B)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Orthologous to human ZC2HC1B (zinc finger C2HC-type containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: B9EHC9
Entrez ID: 75122
|
Does Knockout of Rhoj in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Rhoj
|
phagocytosis
|
macrophage
|
Gene: Rhoj (ras homolog family member J)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, actin filament organization, angiogenesis, endocytosis, establishment of cell polarity, positive regulation of cell migration involved in sprouting angiogenesis, regulation of cell shape, regulation of endothelial cell migration, regulation of sprouting angiogenesis, retina vasculature morphogenesis in camera-type eye, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: membrane, plasma membrane
Pathways: RHO GTPase cycle, RHOJ GTPase cycle, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9ER71
Entrez ID: 80837
|
Does Knockout of Mrpl42 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Mrpl42
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mrpl42 (mitochondrial ribosomal protein L42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial small ribosomal subunit, mitochondrion, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPV3
Entrez ID: 67270
|
Does Knockout of Serpinf2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Serpinf2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Serpinf2 (serine (or cysteine) peptidase inhibitor, clade F, member 2)
Type: protein-coding
Summary: Predicted to enable protease binding activity; protein homodimerization activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including collagen fibril organization; maintenance of blood vessel diameter homeostasis by renin-angiotensin; and positive regulation of biosynthetic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; pancreas epithelium; urinary system; and yolk sac. Used to study alpha-2-plasmin inhibitor deficiency. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: acute-phase response, blood vessel morphogenesis, collagen fibril organization, maintenance of blood vessel diameter homeostasis by renin-angiotensin, negative regulation of fibrinolysis, negative regulation of plasminogen activation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of cell differentiation, positive regulation of coagulation, positive regulation of collagen biosynthetic process, positive regulation of smooth muscle cell proliferation, positive regulation of stress fiber assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta production; MF: endopeptidase inhibitor activity, peptidase inhibitor activity, protease binding, protein homodimerization activity, serine-type endopeptidase inhibitor activity; CC: cell surface, extracellular matrix, extracellular region, extracellular space, fibrinogen complex
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Dissolution of Fibrin Clot, Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q61247
Entrez ID: 18816
|
Does Knockout of Sema4c in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sema4c
|
cell proliferation
|
Regulatory T cell
|
Gene: Sema4c (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C)
Type: protein-coding
Summary: This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: axon guidance, cell differentiation, cell migration in hindbrain, cerebellum development, muscle cell differentiation, negative chemotaxis, nervous system development, neural crest cell migration, neural tube closure, positive regulation of cell migration, positive regulation of stress-activated MAPK cascade, regulation of postsynapse assembly, semaphorin-plexin signaling pathway; MF: chemorepellent activity, neuropilin binding, protein binding, semaphorin receptor binding; CC: cytoplasmic vesicle, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic vesicle membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q64151
Entrez ID: 20353
|
Does Knockout of Psme3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Psme3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psme3 (proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki))
Type: protein-coding
Summary: Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, regulation of G1/S transition of mitotic cell cycle, regulation of proteasomal protein catabolic process; MF: MDM2/MDM4 family protein binding, endopeptidase activator activity, identical protein binding, p53 binding; CC: ciliary basal body, cilium, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome activator complex, proteasome complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Proteasome - Mus musculus (mouse), Proteasome assembly
UniProt: P61290
Entrez ID: 19192
|
Does Knockout of Mplkip in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mplkip
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mplkip (M-phase specific PLK1 intereacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, centrosome, cytoplasm, cytoskeleton, midbody, nucleoplasm, nucleus
Pathways:
UniProt: Q9D011
Entrez ID: 66308
|
Does Knockout of Eva1a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Eva1a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Eva1a (eva-1 homolog A, regulator of programmed cell death)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, apoptotic process, autophagy, biological_process, cardiac left ventricle morphogenesis, connective tissue replacement, energy reserve metabolic process, heart development, lung development, post-embryonic development; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q91WM6
Entrez ID: 232146
|
Does Knockout of Supt7l in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Supt7l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Supt7l (SPT7-like, STAGA complex gamma subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of protein location in nucleus, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleoplasm, nucleus
Pathways:
UniProt: Q9CZV5
Entrez ID: 72195
|
Does Knockout of Stx17 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Stx17
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Stx17 (syntaxin 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, autophagosome maturation, autophagosome membrane docking, autophagosome-lysosome fusion, autophagy, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment organization, exocytosis, intracellular protein transport, protein localization to phagophore assembly site, vesicle docking, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein kinase binding, protein phosphatase binding; CC: COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, HOPS complex, SNARE complex, autolysosome membrane, autophagosome, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, lysosome, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrion, plasma membrane, smooth endoplasmic reticulum membrane
Pathways: Asparagine N-linked glycosylation, Autophagy - animal - Mus musculus (mouse), COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9D0I4
Entrez ID: 67727
|
Does Knockout of Top2b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Top2b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Top2b (topoisomerase (DNA) II beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA metabolic process, DNA topological change, axonogenesis, cellular response to ATP, cellular response to hydrogen peroxide, cellular senescence, forebrain development, neuron migration, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, resolution of meiotic recombination intermediates, sister chromatid segregation; MF: ATP binding, DNA binding, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, chromatin binding, isomerase activity, metal ion binding, nucleotide binding, protein binding, ribonucleoprotein complex binding; CC: cytosol, heterochromatin, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q64511
Entrez ID: 21974
|
Does Knockout of Plpp1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Plpp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Plpp1 (phospholipid phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide metabolic process, diacylglycerol biosynthetic process, lipid metabolic process, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction, sphingosine metabolic process; MF: ceramide-1-phosphate phosphatase activity, diacylglycerol diphosphate phosphatase activity, hydrolase activity, lipid phosphatase activity, lysophosphatidic acid phosphatase activity, phosphatidate phosphatase activity, sphingosine-1-phosphate phosphatase activity; CC: apical plasma membrane, caveola, membrane, membrane raft, plasma membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), triacylglycerol biosynthesis
UniProt: Q61469
Entrez ID: 19012
|
Does Knockout of Usp25 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Usp25
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Usp25 (ubiquitin specific peptidase 25)
Type: protein-coding
Summary: Predicted to enable SUMO binding activity; cysteine-type deubiquitinase activity; and enzyme binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; intracellular signal transduction; and response to oxidative stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Orthologous to human USP25 (ubiquitin specific peptidase 25). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: immune response, interleukin-17-mediated signaling pathway, interleukin-17A-mediated signaling pathway, mRNA metabolic process, negative regulation of ERAD pathway, negative regulation of interleukin-17-mediated signaling pathway, negative regulation of response to oxidative stress, protein K48-linked deubiquitination, protein K48-linked ubiquitination, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of protein stability, response to oxidative stress, stress-activated protein kinase signaling cascade, ubiquitin-dependent protein catabolic process; MF: ATPase binding, SUMO binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleus, proteasome complex
Pathways: Deubiquitination, IL-17 signaling pathway - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: P57080
Entrez ID: 30940
|
Does Knockout of Ano1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ano1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ano1 (anoctamin 1, calcium activated chloride channel)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to heat, cellular response to peptide, chloride transmembrane transport, chloride transport, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, establishment of localization in cell, glial cell projection elongation, iodide transport, monoatomic ion transmembrane transport, monoatomic ion transport, mucus secretion, phospholipase C-activating G protein-coupled receptor signaling pathway, protein localization to membrane, regulation of membrane potential, trachea development; MF: calcium-activated cation channel activity, chloride channel activity, identical protein binding, intracellularly calcium-gated chloride channel activity, iodide transmembrane transporter activity, metal ion binding, protein binding, protein dimerization activity, protein homodimerization activity, signaling receptor binding, voltage-gated chloride channel activity; CC: apical plasma membrane, cell projection, chloride channel complex, external side of plasma membrane, glutamatergic synapse, membrane, nucleoplasm, plasma membrane, presynapse, presynaptic membrane, synapse
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BHY3
Entrez ID: 101772
|
Does Knockout of Ndufa2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ndufa2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ndufa2 (NADH:ubiquinone oxidoreductase subunit A2)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: aerobic respiration, blastocyst hatching, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ75
Entrez ID: 17991
|
Does Knockout of Crtc2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Crtc2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Crtc2 (CREB regulated transcription coactivator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cAMP, gluconeogenesis, glucose homeostasis, positive regulation of CREB transcription factor activity, positive regulation of transcription by RNA polymerase II, protein homotetramerization; MF: cAMP response element binding protein binding, chromatin binding, protein binding, transcription coactivator activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: Q3U182
Entrez ID: 74343
|
Does Knockout of Lama4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Lama4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lama4 (laminin, alpha 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, brown fat cell differentiation, cell adhesion, negative regulation of cold-induced thermogenesis, regulation of cell adhesion, regulation of cell migration, regulation of embryonic development; MF: extracellular matrix structural constituent, signaling receptor binding; CC: basement membrane, extracellular matrix, extracellular region, neuromuscular junction, synapse, synaptic cleft
Pathways: African trypanosomiasis - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Formation of the dystrophin-glycoprotein complex (DGC), Human papillomavirus infection - Mus musculus (mouse), Laminin interactions, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: P97927
Entrez ID: 16775
|
Does Knockout of Gins1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Gins1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gins1 (GINS complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA strand elongation involved in mitotic DNA replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9CZ15
Entrez ID: 69270
|
Does Knockout of Pbx2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Pbx2
|
cell cycle progression
|
breast epithelium
|
Gene: Pbx2 (pre B cell leukemia homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, brain development, embryonic limb morphogenesis, embryonic organ development, eye development, neuron development, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: O35984
Entrez ID: 18515
|
Does Knockout of Ankrd49 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ankrd49
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ankrd49 (ankyrin repeat domain 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of DNA-templated transcription, spermatogenesis
Pathways:
UniProt: Q8VE42
Entrez ID: 56503
|
Does Knockout of Slc15a4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Slc15a4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Slc15a4 (solute carrier family 15, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-histidine transmembrane export from vacuole, dipeptide import across plasma membrane, histidine transport, immune system process, innate immune response, mast cell homeostasis, oligopeptide transport, peptide transport, peptidoglycan transport, positive regulation of innate immune response, positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of toll-like receptor 7 signaling pathway, positive regulation of toll-like receptor 8 signaling pathway, positive regulation of toll-like receptor 9 signaling pathway, protein transport, proton transmembrane transport, regulation of isotype switching to IgG isotypes, regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, transmembrane transport; MF: L-histidine transmembrane transporter activity, dipeptide transmembrane transporter activity, peptide:proton symporter activity, peptidoglycan transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: early endosome membrane, endolysosome membrane, endosome, endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Proton/oligopeptide cotransporters, SLC-mediated transmembrane transport, SLC-mediated transport of oligopeptides, SLC15A4:TASL-dependent IRF5 activation, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Transport of small molecules
UniProt: Q91W98
Entrez ID: 100561
|
Does Knockout of A630076J17Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
A630076J17Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: A630076J17Rik (RIKEN cDNA A630076J17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319929
|
Does Knockout of Xrn2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Xrn2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Xrn2 (5'-3' exoribonuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA-templated transcription termination, RNA metabolic process, hippocampus development, mRNA processing, microtubule-based process, neuron differentiation, nuclear-transcribed mRNA catabolic process, nucleobase-containing compound metabolic process, retina development in camera-type eye, spermatogenesis, termination of RNA polymerase II transcription; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, RNA binding, exonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, nucleic acid binding, protein binding, transcription termination site sequence-specific DNA binding, zinc ion binding; CC: aggresome, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBR1
Entrez ID: 24128
|
Does Knockout of Rilpl1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Rilpl1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Rilpl1 (Rab interacting lysosomal protein-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, epithelial cell morphogenesis, nitric oxide mediated signal transduction, protein transport, protein transport from ciliary membrane to plasma membrane; MF: dynein light intermediate chain binding, protein dimerization activity, small GTPase binding; CC: cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9JJC6
Entrez ID: 75695
|
Does Knockout of Idi1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Idi1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Idi1 (isopentenyl-diphosphate delta isomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, dimethylallyl diphosphate biosynthetic process, isopentenyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid metabolic process, response to stilbenoid, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: isomerase activity, isopentenyl-diphosphate delta-isomerase activity, magnesium ion binding, manganese ion binding, metal ion binding; CC: cytoplasm, cytosol, mitochondrion, peroxisome
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Terpenoid backbone biosynthesis - Mus musculus (mouse), mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: P58044
Entrez ID: 319554
|
Does Knockout of Alkbh6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Alkbh6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Alkbh6 (alkB homolog 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 2-oxoglutarate-dependent dioxygenase activity, dioxygenase activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, focal adhesion, nucleoplasm, nucleus
Pathways:
UniProt: Q8K2U2
Entrez ID: 233065
|
Does Knockout of Accsl in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Accsl
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Accsl (1-aminocyclopropane-1-carboxylate synthase (inactive)-like)
Type: protein-coding
Summary: Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: pyridoxal phosphate binding, transaminase activity
Pathways:
UniProt: Q3UX83
Entrez ID: 381411
|
Does Knockout of Tspear in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Tspear
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tspear (thrombospondin type laminin G domain and EAR repeats)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, hair cycle process, regulation of Notch signaling pathway, sensory perception of sound, signal transduction, tooth mineralization; CC: cell projection, cell surface, ciliary membrane, extracellular region, stereocilium
Pathways:
UniProt: J3S6Y1
Entrez ID: 252974
|
Does Knockout of Myo16 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Myo16
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Myo16 (myosin XVI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cell population proliferation, neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, nucleotide binding, protein binding, protein phosphatase binding, protein-containing complex binding; CC: cytoplasm, myosin complex, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q5DU14
Entrez ID: 244281
|
Does Knockout of Recql4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Recql4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Recql4 (RecQ protein-like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA replication, chromosome organization, double-strand break repair via homologous recombination, negative regulation of sister chromatid cohesion, pigmentation, positive regulation of cell population proliferation, skeletal system development, skeletal system morphogenesis, telomere maintenance, telomeric D-loop disassembly; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, bubble DNA binding, four-way junction helicase activity, helicase activity, hydrolase activity, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, oxidized purine DNA binding, telomeric D-loop binding, zinc ion binding; CC: chromosome, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q75NR7
Entrez ID: 79456
|
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