prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Strn in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Strn
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Strn (striatin, calmodulin binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, dendrite development, locomotory behavior, negative regulation of cell population proliferation, regulation of modification of postsynaptic structure, regulation of signal transduction; MF: armadillo repeat domain binding, calmodulin binding, nuclear estrogen receptor binding, protein binding, protein domain specific binding, protein phosphatase 2A binding, protein-containing complex binding, protein-macromolecule adaptor activity; CC: FAR/SIN/STRIPAK complex, bicellular tight junction, cell junction, cell projection, cytoplasm, dendrite, dendritic spine, glutamatergic synapse, membrane, neuronal cell body, postsynapse, postsynaptic density, postsynaptic membrane, protein-containing complex, synapse
Pathways: ESR-mediated signaling, Extra-nuclear estrogen signaling, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Signal Transduction, Signaling by Nuclear Receptors
UniProt: O55106
Entrez ID: 268980
|
Does Knockout of Ndrg4 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ndrg4
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ndrg4 (N-myc downstream regulated gene 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration involved in heart development, negative regulation of platelet-derived growth factor receptor signaling pathway, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of neuron projection development, regulation of endocytic recycling, signal transduction, vesicle docking, visual learning; CC: basolateral plasma membrane, cell projection membrane, cytoplasm, cytosol, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8BTG7
Entrez ID: 234593
|
Does Knockout of Polr3b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Polr3b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Polr3b (polymerase (RNA) III (DNA directed) polypeptide B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, rRNA transcription, snRNA transcription by RNA polymerase III, transcription by RNA polymerase III; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, cytosol, nuclear DNA-directed RNA polymerase complex, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: P59470
Entrez ID: 70428
|
Does Knockout of Gm5148 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Gm5148
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm5148 (predicted gene 5148)
Type: protein-coding
Summary: predicted gene 5148
Gene Ontology:
Pathways:
UniProt: Q8BGG2
Entrez ID: 381438
|
Does Knockout of Nsmce2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Nsmce2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nsmce2 (NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, cellular senescence, double-strand break repair via homologous recombination, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of mitotic metaphase/anaphase transition, protein sumoylation, protein ubiquitination, telomere maintenance via recombination; MF: SUMO ligase activity, SUMO transferase activity, metal ion binding, transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, Smc5-Smc6 complex, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q91VT1
Entrez ID: 68501
|
Does Knockout of 2510039O18Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
2510039O18Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 2510039O18Rik (RIKEN cDNA 2510039O18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q91X21
Entrez ID: 77034
|
Does Knockout of Notch1 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,197
|
Knockout
|
Notch1
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Notch1 (notch 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, T-helper 17 type immune response, angiogenesis, animal organ regeneration, aortic valve morphogenesis, apoptotic process involved in embryonic digit morphogenesis, arterial endothelial cell differentiation, artery morphogenesis, astrocyte differentiation, atrioventricular node development, atrioventricular valve morphogenesis, auditory receptor cell fate commitment, axon guidance, axonogenesis, branching morphogenesis of an epithelial tube, camera-type eye morphogenesis, cardiac atrium morphogenesis, cardiac chamber formation, cardiac epithelial to mesenchymal transition, cardiac left ventricle morphogenesis, cardiac muscle cell myoblast differentiation, cardiac muscle cell proliferation, cardiac muscle tissue morphogenesis, cardiac right atrium morphogenesis, cardiac right ventricle formation, cardiac septum morphogenesis, cardiac vascular smooth muscle cell development, cardiac ventricle morphogenesis, cell differentiation, cell differentiation in spinal cord, cell fate commitment, cell migration involved in endocardial cushion formation, cellular response to follicle-stimulating hormone stimulus, cellular response to hypoxia, cellular response to tumor cell, cellular response to vascular endothelial growth factor stimulus, central nervous system neuron differentiation, chemical synaptic transmission, postsynaptic, cilium assembly, collecting duct development, compartment pattern specification, coronary artery morphogenesis, coronary sinus valve morphogenesis, coronary vein morphogenesis, determination of left/right symmetry, developmental growth, distal tubule development, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, endocardial cell differentiation, endocardial cushion development, endocardial cushion morphogenesis, endocardium development, endocardium morphogenesis, endoderm development, epidermal cell fate specification, epidermis development, epithelial cell development, epithelial cell differentiation involved in kidney development, epithelial cell fate commitment, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, forebrain development, foregut morphogenesis, gene expression, glial cell differentiation, glomerular mesangial cell development, glomerulus vasculature development, growth involved in heart morphogenesis, hair follicle morphogenesis, heart development, heart looping, heart trabecula morphogenesis, homeostasis of number of cells within a tissue, humoral immune response, in utero embryonic development, inflammatory response to antigenic stimulus, inhibition of neuroepithelial cell differentiation, interleukin-17-mediated signaling pathway, keratinocyte differentiation, left/right axis specification, liver development, lung development, luteolysis, mesenchymal cell development, mitral valve formation, morphogenesis of an epithelial sheet, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of anoikis, negative regulation of biomineral tissue development, negative regulation of calcium ion-dependent exocytosis, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cardiac muscle hypertrophy, negative regulation of catalytic activity, negative regulation of cell adhesion molecule production, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of cell-cell adhesion mediated by cadherin, negative regulation of cell-substrate adhesion, negative regulation of cold-induced thermogenesis, negative regulation of collagen biosynthetic process, negative regulation of endothelial cell chemotaxis, negative regulation of epithelial cell proliferation, negative regulation of extracellular matrix constituent secretion, negative regulation of gene expression, negative regulation of glial cell proliferation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of myoblast differentiation, negative regulation of myotube differentiation, negative regulation of neurogenesis, negative regulation of neuron differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of ossification, negative regulation of osteoblast differentiation, negative regulation of photoreceptor cell differentiation, negative regulation of pro-B cell differentiation, negative regulation of programmed cell death, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, nephron tubule development, neural tube development, neuroendocrine cell differentiation, neuron differentiation, neuron fate commitment, neuronal stem cell population maintenance, oligodendrocyte differentiation, osteoblast fate commitment, outflow tract morphogenesis, pericardium morphogenesis, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of Notch signaling pathway, positive regulation of Ras protein signal transduction, positive regulation of aorta morphogenesis, positive regulation of apoptotic process, positive regulation of apoptotic process involved in morphogenesis, positive regulation of astrocyte differentiation, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cardiac muscle cell proliferation, positive regulation of cell development, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of endothelial cell differentiation, positive regulation of ephrin receptor signaling pathway, positive regulation of epithelial cell differentiation, positive regulation of epithelial cell proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of glial cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of neuroblast proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of Notch receptor target, positive regulation of viral genome replication, positive regulation of viral transcription, prostate gland epithelium morphogenesis, protein catabolic process, protein import into nucleus, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of Notch signaling pathway, regulation of apoptotic process, regulation of cardioblast proliferation, regulation of cell adhesion involved in heart morphogenesis, regulation of cell migration, regulation of cell population proliferation, regulation of developmental process, regulation of epithelial cell proliferation, regulation of epithelial cell proliferation involved in prostate gland development, regulation of extracellular matrix assembly, regulation of gene expression, regulation of inner ear auditory receptor cell differentiation, regulation of neurogenesis, regulation of secondary heart field cardioblast proliferation, regulation of somitogenesis, regulation of stem cell proliferation, regulation of transcription by RNA polymerase II, reproductive structure development, response to lipopolysaccharide, response to muramyl dipeptide, retinal cone cell differentiation, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, skeletal muscle cell differentiation, somatic stem cell division, spermatogenesis, sprouting angiogenesis, tissue regeneration, tube formation, vasculogenesis involved in coronary vascular morphogenesis, venous blood vessel morphogenesis, venous endothelial cell differentiation, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: Notch binding, calcium ion binding, chromatin DNA binding, chromatin binding, enzyme binding, enzyme inhibitor activity, identical protein binding, metal ion binding, protein binding, signaling receptor activity, transcription coactivator activity, transcription regulator activator activity, transmembrane signaling receptor activity; CC: Golgi membrane, MAML1-RBP-Jkappa- ICN1 complex, Schaffer collateral - CA1 synapse, acrosomal vesicle, adherens junction, apical plasma membrane, cell periphery, cell surface, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular region, glutamatergic synapse, lamellipodium, late endosome membrane, membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic density membrane, receptor complex, ruffle
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Breast cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, Pathways in cancer - Mus musculus (mouse), Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Th1 and Th2 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation by RUNX3
UniProt: Q01705
Entrez ID: 18128
|
Does Knockout of Cilp in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Cilp
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of SMAD protein signal transduction, negative regulation of gene expression, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q66K08
Entrez ID: 214425
|
Does Knockout of Tor1aip1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tor1aip1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tor1aip1 (torsin A interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear membrane organization, positive regulation of ATP-dependent activity, protein localization to nuclear envelope; MF: ATPase activator activity, ATPase binding, cytoskeletal protein binding, lamin binding, protein binding; CC: membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q921T2
Entrez ID: 208263
|
Does Knockout of Thbs4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Thbs4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Thbs4 (thrombospondin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to pain, cell adhesion, endothelial cell-cell adhesion, myoblast migration, negative regulation of angiogenesis, nervous system development, neuron projection morphogenesis, positive regulation of cell division, positive regulation of endothelial cell proliferation, positive regulation of neutrophil chemotaxis, regulation of tissue remodeling, response to endoplasmic reticulum stress, response to unfolded protein, signal transduction, tissue remodeling; MF: calcium ion binding, collagen binding, extracellular matrix structural constituent, fibronectin binding, growth factor activity, heparin binding, identical protein binding, integrin binding, laminin-1 binding, protein binding; CC: basement membrane, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, neuromuscular junction, sarcoplasmic reticulum
Pathways: ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Malaria - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: Q9Z1T2
Entrez ID: 21828
|
Does Knockout of Psmg4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Psmg4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Psmg4 (proteasome (prosome, macropain) assembly chaperone 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome assembly; MF: molecular_function, protein binding, protein-containing complex binding; CC: cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: P0C7N9
Entrez ID: 69666
|
Does Knockout of Cdk13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Cdk13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdk13 (cyclin dependent kinase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, hemopoiesis, mRNA processing, negative regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, cytosol, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Neutrophil degranulation, RNA Polymerase II Transcription, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q69ZA1
Entrez ID: 69562
|
Does Knockout of Mtfp1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mtfp1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mtfp1 (mitochondrial fission process 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitochondrial fission, mitochondrial membrane organization, mitochondrion organization; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CRB8
Entrez ID: 67900
|
Does Knockout of Cetn1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Cetn1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cetn1 (centrin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cellular response to heat, centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding, microtubule binding; CC: cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus, photoreceptor connecting cilium, spindle pole
Pathways: Aggrephagy, Autophagy, Macroautophagy, Selective autophagy
UniProt: P41209
Entrez ID: 26369
|
Does Knockout of Cdca5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Cdca5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdca5 (cell division cycle associated 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, double-strand break repair, mitotic sister chromatid cohesion; MF: protein binding, protein-containing complex binding; CC: chromatin, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, M Phase, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Resolution of Sister Chromatid Cohesion, S Phase, Separation of Sister Chromatids
UniProt: Q9CPY3
Entrez ID: 67849
|
Does Knockout of Tstd2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tstd2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tstd2 (thiosulfate sulfurtransferase (rhodanese)-like domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3U269
Entrez ID: 272027
|
Does Knockout of Ms4a18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ms4a18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ms4a18 (membrane-spanning 4-domains, subfamily A, member 18)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MS4A18 (membrane spanning 4-domains A18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: J3QN01
Entrez ID: 76002
|
Does Knockout of Mex3b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Mex3b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mex3b (mex3 RNA binding family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, positive regulation of cell-cell adhesion, positive regulation of phagocytosis, protein localization to cell cortex; MF: GTPase activating protein binding, RNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: F8WJD6
Entrez ID: 108797
|
Does Knockout of Lmo7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Lmo7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lmo7 (LIM domain only 7)
Type: protein-coding
Summary: Predicted to enable actinin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and nuclear envelope. Is expressed in several structures, including brain; branchial arch; heart; sensory organ; and urinary system. Orthologous to human LMO7 (LIM domain 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways: Adaptive Immune System, Adherens junction - Mus musculus (mouse), Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: E9PYF4, E9PYI7, A0AAQ4VMW3, A0T1J8, Q6ZQ32, Q3UPW3, F6VG99, A0A5F8MPW2, F6TFN2, A0AAQ4VMV9, A0AAQ4VMW6, E0CZD8
Entrez ID: 380928
|
Does Knockout of Arhgef7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Arhgef7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Arhgef7 (Rho guanine nucleotide exchange factor)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including genitourinary system; liver; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi organization, Rho protein signal transduction, astrocyte cell migration, hematopoietic progenitor cell differentiation, intracellular signal transduction, lamellipodium assembly, negative regulation of microtubule nucleation, nervous system development, positive regulation of apoptotic process, positive regulation of growth hormone secretion, postsynaptic actin cytoskeleton organization, presynaptic actin cytoskeleton organization, small GTPase-mediated signal transduction; MF: gamma-tubulin binding, guanyl-nucleotide exchange factor activity, protein binding, protein kinase binding, small GTPase binding; CC: GABA-ergic synapse, anchoring junction, cell cortex, cell projection, centrosome, cytoplasm, cytosol, focal adhesion, growth cone, lamellipodium, mitotic spindle pole, neuron projection, neuronal cell body, plasma membrane, postsynapse, protein-containing complex, ruffle, storage vacuole
Pathways: Regulation of actin cytoskeleton - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q9ES28
Entrez ID: 54126
|
Does Knockout of Thoc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Thoc1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Thoc1 (THO complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA export from nucleus, mRNA processing, mRNA transport, regulation of apoptotic process, signal transduction; MF: DNA binding, RNA binding, identical protein binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, cytosol, nuclear matrix, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q8R3N6
Entrez ID: 225160
|
Does Knockout of Foxl1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Foxl1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Foxl1 (forkhead box L1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Peyer's patch morphogenesis, anatomical structure morphogenesis, cell differentiation, heart development, proteoglycan biosynthetic process, regulation of DNA-templated transcription, regulation of Wnt signaling pathway, regulation of transcription by RNA polymerase II, visceral mesoderm-endoderm interaction involved in midgut development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q64731
Entrez ID: 14241
|
Does Knockout of Gm3336 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Gm3336
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm3336 (predicted gene 3336)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: A0A1D5RMG6, J3QMQ6
Entrez ID: 100502950
|
Does Knockout of Mcm5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mcm5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mcm5 (minichromosome maintenance complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, premeiotic DNA replication; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA replication origin binding, helicase activity, hydrolase activity, nucleotide binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: P49718
Entrez ID: 17218
|
Does Knockout of Csnk2b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Csnk2b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Csnk2b (casein kinase 2, beta polypeptide)
Type: protein-coding
Summary: This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: Wnt signaling pathway, adiponectin-activated signaling pathway, endothelial tube morphogenesis, negative regulation of blood vessel endothelial cell migration, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of viral life cycle, positive regulation of SMAD protein signal transduction, positive regulation of activin receptor signaling pathway, release from viral latency, symbiont-mediated disruption of host cell PML body; MF: RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, identical protein binding, metal ion binding, protein binding, protein domain specific binding, protein kinase regulator activity, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, ribonucleoprotein complex binding, signaling receptor binding; CC: PML body, PcG protein complex, cell projection, chromatin, cytoplasm, cytosol, fibrillar center, nuclear matrix, nucleoplasm, nucleus, plasma membrane, protein kinase CK2 complex
Pathways: Adaptive Immune System, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Autophagy, Axon guidance, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chaperonin-mediated protein folding, Co-inhibition by PD-1, Condensation of Prometaphase Chromosomes, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, Glycerophospholipid biosynthesis, Immune System, Innate Immune System, Intracellular signaling by second messengers, L1CAM interactions, M Phase, Macroautophagy, Measles - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Prometaphase, NF-kappa B signaling pathway - Mus musculus (mouse), Nervous system development, Neutrophil degranulation, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipid metabolism, Prion disease - Mus musculus (mouse), Protein folding, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Receptor Mediated Mitophagy, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), SPOP-mediated proteasomal degradation of PD-L1(CD274), Selective autophagy, Signal Transduction, Signal transduction by L1, Signaling by WNT, Synthesis of PC, TCF dependent signaling in response to WNT, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, WNT mediated activation of DVL, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P67871
Entrez ID: 13001
|
Does Knockout of Zbtb8a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Zbtb8a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zbtb8a (zinc finger and BTB domain containing 8a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, molecular_function, transcription cis-regulatory region binding, transcription coactivator binding, zinc ion binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q9CWH1
Entrez ID: 73680
|
Does Knockout of Nfx1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Nfx1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nfx1 (nuclear transcription factor, X-box binding 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of MHC class II biosynthetic process, negative regulation of transcription by RNA polymerase II, protein autoubiquitination; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: B1AY10
Entrez ID: 74164
|
Does Knockout of Plcb1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Plcb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Plcb1 (phospholipase C, beta 1)
Type: protein-coding
Summary: Enables lamin binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in chromatin; cytoplasm; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, G2/M transition of mitotic cell cycle, activation of meiosis involved in egg activation, brain development, cell adhesion, cellular response to fluoride, cellular response to glyceraldehyde, cellular response to ionomycin, cellular response to peptide hormone stimulus, cellular response to vasopressin, cerebral cortex development, erythrocyte differentiation, fat cell differentiation, glutamate receptor signaling pathway, inositol trisphosphate metabolic process, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, interleukin-1-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, intracellular signal transduction, learning, ligand-gated ion channel signaling pathway, lipid catabolic process, lipid metabolic process, mRNA processing, macrophage differentiation, memory, negative regulation of DNA-templated transcription, negative regulation of monocyte extravasation, oocyte maturation, phosphatidylinositol catabolic process, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating adrenergic receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of JNK cascade, positive regulation of acrosome reaction, positive regulation of developmental growth, positive regulation of embryonic development, positive regulation of glycoprotein biosynthetic process, positive regulation of insulin secretion, positive regulation of interleukin-12 production, positive regulation of myoblast differentiation, postsynaptic modulation of chemical synaptic transmission, regulation of G protein-coupled receptor signaling pathway, regulation of establishment of endothelial barrier, regulation of fertilization, regulation of retrograde trans-synaptic signaling by endocanabinoid, release of sequestered calcium ion into cytosol, response to monosaccharide, response to peptide hormone, signal transduction; MF: GTPase activator activity, calcium ion binding, calmodulin binding, enzyme binding, hydrolase activity, identical protein binding, lamin binding, phosphatidylinositol phospholipase C activity, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phosphoric diester hydrolase activity, protein binding; CC: GABA-ergic synapse, chromatin, cytoplasm, glutamatergic synapse, membrane, myelin sheath, nuclear membrane, nuclear speck, nucleus, plasma membrane, postsynaptic cytosol, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acetylcholine regulates insulin secretion, Activation of kainate receptors upon glutamate binding, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), African trypanosomiasis - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium signaling pathway - Mus musculus (mouse), Carbohydrate digestion and absorption - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acids regulate insulin secretion, G alpha (i) signalling events, G alpha (q) signalling events, G beta:gamma signalling through PLC beta, G-protein beta:gamma signalling, G-protein mediated events, GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Lipid and atherosclerosis - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Metabolism, NOD-like receptor signaling pathway - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neutrophil extracellular trap formation - Mus musculus (mouse), Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), PIP metabolism, PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Presynaptic function of Kainate receptors, Rap1 signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, Taste transduction - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transmission across Chemical Synapses, Vascular smooth muscle contraction - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), phospholipases
UniProt: Q9Z1B3
Entrez ID: 18795
|
Does Knockout of Usp34 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Usp34
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Usp34 (ubiquitin specific peptidase 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of protein stability, regulation of signal transduction; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytosol, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Ub-specific processing proteases
UniProt: Q6ZQ93
Entrez ID: 17847
|
Does Knockout of Nmbr in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Nmbr
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Nmbr (neuromedin B receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antiviral innate immune response, bombesin receptor signaling pathway, negative regulation of interleukin-6 production, neuropeptide signaling pathway, positive regulation of interferon-alpha production, positive regulation of osteoclast proliferation, positive regulation of respiratory gaseous exchange, signal transduction, sneeze reflex; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, bombesin receptor activity, neuropeptide receptor activity; CC: cytosol, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O54799
Entrez ID: 18101
|
Does Knockout of Plagl2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Plagl2
|
cell cycle progression
|
breast epithelium
|
Gene: Plagl2 (pleiomorphic adenoma gene-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chylomicron assembly, lipid metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q925T4
Entrez ID: 54711
|
Does Knockout of Ivl in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ivl
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ivl (involucrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: keratinization, keratinocyte differentiation, regulation of antibacterial peptide production, response to UV-B; CC: centrosome, cornified envelope, cytoplasm, cytosol, nuclear body
Pathways:
UniProt: G3X9D9
Entrez ID: 16447
|
Does Knockout of Adra2c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Adra2c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Adra2c (adrenergic receptor, alpha 2c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, epidermal growth factor receptor signaling pathway, female pregnancy, negative regulation of norepinephrine secretion, negative regulation of uterine smooth muscle contraction, platelet activation, positive regulation of MAPK cascade, positive regulation of neuron differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of vasoconstriction, regulation of smooth muscle contraction, regulation of vasoconstriction, signal transduction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha-2A adrenergic receptor binding, alpha2-adrenergic receptor activity, epinephrine binding, protein heterodimerization activity, protein homodimerization activity; CC: axon, axon terminus, cytoplasm, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic density membrane, postsynaptic membrane
Pathways: Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (z) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Integration of energy metabolism, Metabolism, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Regulation of insulin secretion, Signal Transduction, Signaling by GPCR, Surfactant metabolism, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q01337
Entrez ID: 11553
|
Does Knockout of Col9a3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Col9a3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Col9a3 (collagen, type IX, alpha 3)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be part of collagen type IX trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including brain; cranium; hindlimb digit mesenchyme; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in Stickler syndrome; multiple epiphyseal dysplasia 3; and osteochondrodysplasia. Orthologous to human COL9A3 (collagen type IX alpha 3 chain). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: female gonad development, male gonad development; MF: extracellular matrix structural constituent conferring tensile strength, protein homodimerization activity; CC: basement membrane, collagen trimer, collagen type IX trimer, extracellular matrix
Pathways: Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Developmental Biology, ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: Q8BSX1, A2ACT7
Entrez ID: 12841
|
Does Knockout of Vps35 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Vps35
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Vps35 (VPS35 retromer complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, intracellular protein transport, lysosome organization, mitochondrial fragmentation involved in apoptotic process, mitochondrion to lysosome vesicle-mediated transport, modulation of chemical synaptic transmission, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of late endosome to lysosome transport, negative regulation of lysosomal protein catabolic process, negative regulation of protein homooligomerization, negative regulation of protein localization, neurotransmitter receptor transport, endosome to plasma membrane, neurotransmitter receptor transport, endosome to postsynaptic membrane, positive regulation of Wnt protein secretion, positive regulation of canonical Wnt signaling pathway, positive regulation of dopamine biosynthetic process, positive regulation of dopamine receptor signaling pathway, positive regulation of gene expression, positive regulation of locomotion involved in locomotory behavior, positive regulation of mitochondrial fission, positive regulation of protein catabolic process, positive regulation of protein localization, positive regulation of protein localization to cell periphery, positive regulation of signal transduction, protein destabilization, protein localization to endosome, protein transport, regulation of dendritic spine maintenance, regulation of developmental process, regulation of mitochondrion organization, regulation of postsynapse assembly, regulation of postsynapse organization, regulation of protein catabolic process, regulation of protein metabolic process, regulation of protein stability, regulation of synapse maturation, regulation of terminal button organization, regulation of transport, retrograde transport, endosome to Golgi, transcytosis, vacuolar protein processing, vesicle-mediated transport in synapse, voluntary musculoskeletal movement; MF: D1 dopamine receptor binding, protein binding; CC: cytoplasm, cytosol, dopaminergic synapse, early endosome, endosome, endosome membrane, glutamatergic synapse, late endosome, lysosome, membrane, mitochondrion, mitochondrion-derived vesicle, neuron projection, neuronal cell body, perinuclear region of cytoplasm, postsynapse, postsynaptic density, presynapse, retromer complex, retromer, cargo-selective complex, synapse, tubular endosome
Pathways: Endocytosis - Mus musculus (mouse), Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking
UniProt: Q9EQH3
Entrez ID: 65114
|
Does Knockout of Piezo2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Piezo2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Piezo2 (piezo-type mechanosensitive ion channel component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to mechanical stimulus, detection of mechanical stimulus, detection of mechanical stimulus involved in sensory perception, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of membrane potential, response to mechanical stimulus; MF: mechanosensitive monoatomic cation channel activity, mechanosensitive monoatomic ion channel activity, monoatomic cation channel activity, protein binding; CC: cuticular plate, membrane, neuronal cell body membrane, plasma membrane, stereocilium
Pathways:
UniProt: Q8CD54
Entrez ID: 667742
|
Does Knockout of Akr1a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Akr1a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Akr1a1 (aldo-keto reductase family 1, member A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucuronate catabolic process, D-glucuronate catabolic process to D-xylulose 5-phosphate, L-ascorbic acid biosynthetic process, aldehyde catabolic process, cellular detoxification of aldehyde, daunorubicin metabolic process, doxorubicin metabolic process, lipid metabolic process, negative regulation of apoptotic process; MF: L-glucuronate reductase activity, S-nitrosoglutathione reductase (NADH) activity, S-nitrosoglutathione reductase (NADPH) activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, allyl-alcohol dehydrogenase activity, glucuronolactone reductase activity, glycerol dehydrogenase (NADP+) activity, methylglyoxal reductase (NADPH) (acetol producing) activity, oxidoreductase activity; CC: apical plasma membrane, cytoplasm, cytosol, membrane, plasma membrane, synapse
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Biological oxidations, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), D-glucuronate degradation I, Formation of xylulose-5-phosphate, Glutathione conjugation, Glycerolipid metabolism - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), L-ascorbate biosynthesis VI, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, Pyruvate metabolism - Mus musculus (mouse)
UniProt: Q9JII6
Entrez ID: 58810
|
Does Knockout of Ttll4 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Ttll4
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ttll4 (tubulin tyrosine ligase-like family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, peptidyl-glutamic acid modification, protein polyglutamylation, regulation of blastocyst development; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein binding, protein-glutamic acid ligase activity, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q80UG8
Entrez ID: 67534
|
Does Knockout of Mrps12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrps12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrps12 (mitochondrial ribosomal protein S12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: O35680
Entrez ID: 24030
|
Does Knockout of Ubxn1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ubxn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ubxn1 (UBX domain protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of ERAD pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein K48-linked deubiquitination, negative regulation of protein ubiquitination; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K6-linked polyubiquitin modification-dependent protein binding, polyubiquitin modification-dependent protein binding, proteasome regulatory particle binding, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, dendrite, endoplasmic reticulum, neuronal cell body, nucleoplasm, nucleus
Pathways: Asparagine N-linked glycosylation, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q922Y1
Entrez ID: 225896
|
Does Knockout of Letm1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Letm1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Letm1 (leucine zipper-EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium:proton antiporter activity, metal ion binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Z2I0
Entrez ID: 56384
|
Does Knockout of Fam20a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Fam20a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam20a (FAM20A, golgi associated secretory pathway pseudokinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biomineral tissue development, calcium ion homeostasis, enamel mineralization, positive regulation of protein phosphorylation, response to bacterium, tooth eruption; MF: phosphotransferase activity, alcohol group as acceptor, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, extracellular region, extracellular space
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q8CID3
Entrez ID: 208659
|
Does Knockout of Gpbp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gpbp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gpbp1 (GC-rich promoter binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, RNA binding, protein binding; CC: cytosol, nucleus, plasma membrane
Pathways:
UniProt: Q6NXH3
Entrez ID: 73274
|
Does Knockout of Sfswap in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Sfswap
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sfswap (splicing factor SWAP)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, alternative mRNA splicing, via spliceosome, mRNA 5'-splice site recognition, mRNA processing, negative regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding
Pathways:
UniProt: Q3USH5
Entrez ID: 231769
|
Does Knockout of Ap2s1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Ap2s1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in postsynaptic neurotransmitter receptor internalization and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synapse. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-2 adaptor complex, clathrin-coated pit, cytoplasmic side of plasma membrane, extrinsic component of presynaptic endocytic zone membrane, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, membrane coat, plasma membrane, postsynapse, presynapse, synapse, synaptic vesicle
Pathways: Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4
UniProt: P62743
Entrez ID: 232910
|
Does Knockout of Ccdc185 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ccdc185
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ccdc185 (coiled-coil domain containing 185)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3V118
Entrez ID: 433386
|
Does Knockout of Park7 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,543
|
Knockout
|
Park7
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Park7 (Parkinson disease (autosomal recessive, early onset) 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, adult locomotory behavior, androgen receptor signaling pathway, autophagy, cellular detoxification of aldehyde, cellular detoxification of methylglyoxal, cellular response to glyoxal, cellular response to hydrogen peroxide, cellular response to oxidative stress, cellular response to oxygen-containing compound, cellular response to reactive oxygen species, cellular response to stress, detection of oxidative stress, detoxification of copper ion, detoxification of hydrogen peroxide, detoxification of mercury ion, dopamine uptake involved in synaptic transmission, glucose homeostasis, glycolate biosynthetic process, glyoxal catabolic process, glyoxal metabolic process, guanine deglycation, guanine deglycation, glyoxal removal, guanine deglycation, methylglyoxal removal, hydrogen peroxide metabolic process, inflammatory response, insulin secretion, lactate biosynthetic process, membrane depolarization, membrane hyperpolarization, methylglyoxal catabolic process to lactate, methylglyoxal metabolic process, mitochondrion organization, negative regulation of TRAIL-activated apoptotic signaling pathway, negative regulation of death-inducing signaling complex assembly, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of gene expression, negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of neuron apoptotic process, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein K48-linked deubiquitination, negative regulation of protein catabolic process, negative regulation of protein export from nucleus, negative regulation of protein sumoylation, negative regulation of protein ubiquitination, negative regulation of reactive oxygen species biosynthetic process, negative regulation of smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of L-dopa biosynthetic process, positive regulation of NAD(P)H oxidase activity, positive regulation of acute inflammatory response to antigenic stimulus, positive regulation of dopamine biosynthetic process, positive regulation of fertilization, positive regulation of gene expression, positive regulation of interleukin-8 production, positive regulation of mitochondrial electron transport, NADH to ubiquinone, positive regulation of oxidative phosphorylation uncoupler activity, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein-containing complex assembly, positive regulation of reactive oxygen species biosynthetic process, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, protein repair, protein stabilization, proteolysis, regulation of androgen receptor signaling pathway, regulation of inflammatory response, regulation of mitochondrial membrane potential, regulation of neuron apoptotic process, regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of synaptic vesicle endocytosis, removal of superoxide radicals, response to hydrogen peroxide, response to oxidative stress, single fertilization, synaptic transmission, dopaminergic; MF: DNA-binding transcription factor binding, L-dopa decarboxylase activator activity, RNA binding, copper ion binding, cupric ion binding, cuprous ion binding, cytokine binding, enzyme activator activity, enzyme binding, glyoxalase (glycolic acid-forming) activity, hydrolase activity, identical protein binding, kinase binding, mRNA binding, mercury ion binding, nuclear androgen receptor binding, oxidoreductase activity, acting on peroxide as acceptor, oxygen sensor activity, peptidase activity, peptidase inhibitor activity, peroxiredoxin activity, protein binding, protein deglycase activity, protein homodimerization activity, scaffold protein binding, signaling receptor activator activity, signaling receptor binding, small protein activating enzyme binding, superoxide dismutase copper chaperone activity, transcription coactivator activity, tyrosine 3-monooxygenase activator activity, ubiquitin-like protein conjugating enzyme binding, ubiquitin-protein transferase inhibitor activity, ubiquitin-specific protease binding; CC: PML body, axon, cell body, chromatin, cytoplasm, cytosol, endoplasmic reticulum, membrane, membrane raft, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, neuron projection, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, sperm head, synaptic vesicle
Pathways: Aggrephagy, Autophagy, Macroautophagy, Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Selective autophagy
UniProt: Q99LX0
Entrez ID: 57320
|
Does Knockout of Ak1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Ak1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ak1 (adenylate kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP biosynthetic process, AMP metabolic process, ATP metabolic process, inosine biosynthetic process, nucleobase-containing compound metabolic process, nucleoside monophosphate phosphorylation, nucleoside triphosphate biosynthetic process, positive regulation of D-glucose transmembrane transport, regulation of G1/S transition of mitotic cell cycle; MF: AMP kinase activity, ATP binding, dAMP kinase activity, kinase activity, nucleobase-containing compound kinase activity, nucleoside diphosphate kinase activity, nucleoside monophosphate kinase activity, nucleotide binding, phosphotransferase activity, phosphate group as acceptor, transferase activity; CC: cytoplasm, cytosol, outer dense fiber, perinuclear region of cytoplasm, plasma membrane, sarcomere, sperm flagellum
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Thiamine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, purine and pyrimidine metabolism
UniProt: Q9R0Y5
Entrez ID: 11636
|
Does Knockout of Tmem269 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tmem269
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tmem269 (transmembrane protein 269)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D4Y8
Entrez ID: 75180
|
Does Knockout of Ubl5 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ubl5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ubl5 (ubiquitin-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA splicing, via spliceosome, protein modification process; CC: cytoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9EPV8
Entrez ID: 66177
|
Does Knockout of Dexi in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Dexi
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dexi (dexamethasone-induced transcript)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9WUQ7
Entrez ID: 58239
|
Does Knockout of Actr10 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Actr10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Actr10 (ARP10 actin-related protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, retrograde axonal transport of mitochondrion; CC: axon cytoplasm, cytoplasm, cytoskeleton, dynactin complex
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9QZB7
Entrez ID: 56444
|
Does Knockout of Pgm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pgm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pgm1 (phosphoglucomutase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, galactose catabolic process via UDP-galactose, Leloir pathway, glucose metabolic process, glycogen biosynthetic process, glycogen catabolic process; MF: intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity; CC: Z disc, cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), GDP-glucose biosynthesis, Galactose catabolism, Galactose metabolism - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen synthesis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose phosphate pathway - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), UDP-glucose conversion, glucose and glucose-1-phosphate degradation, glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q9D0F9
Entrez ID: 72157
|
Does Knockout of Mapk15 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Mapk15
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mapk15 (mitogen-activated protein kinase 15)
Type: protein-coding
Summary: Predicted to enable MAP kinase activity and chromatin binding activity. Involved in positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; and regulation of cilium assembly. Located in meiotic spindle. Is expressed in several structures, including brain; genitourinary system; limb; nose; and viscerocranium. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, MAPK cascade, dopamine uptake, endoplasmic reticulum organization, intracellular signal transduction, negative regulation of DNA replication, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation, positive regulation of metaphase/anaphase transition of meiosis I, positive regulation of protein catabolic process, positive regulation of protein ubiquitination, positive regulation of spindle assembly, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, protein autophosphorylation, protein localization to ciliary transition zone, regulation of COPII vesicle coating, regulation of autophagy, regulation of cilium assembly, response to estradiol; MF: ATP binding, MAP kinase activity, chromatin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, anchoring junction, autophagosome, bicellular tight junction, cell projection, cell-cell junction, centriole, ciliary basal body, cytoplasm, cytoplasmic vesicle, cytoskeleton, meiotic spindle, nucleus, spindle
Pathways: IL-17 signaling pathway - Mus musculus (mouse)
UniProt: Q80Y86
Entrez ID: 332110
|
Does Knockout of Cdk13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Cdk13
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cdk13 (cyclin dependent kinase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, hemopoiesis, mRNA processing, negative regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, cytosol, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Neutrophil degranulation, RNA Polymerase II Transcription, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q69ZA1
Entrez ID: 69562
|
Does Knockout of Mecr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Mecr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mecr (mitochondrial trans-2-enoyl-CoA reductase)
Type: protein-coding
Summary: Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ceramide biosynthetic process, fatty acid biosynthetic process, fatty acid metabolic process, intracellular iron ion homeostasis, lipid metabolic process; MF: enoyl-[acyl-carrier-protein] reductase (NADPH) activity, nuclear receptor binding, oxidoreductase activity, signaling receptor binding; CC: cytosol, membrane, mitochondrion, nucleus
Pathways: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, mitochondrial fatty acid beta-oxidation of saturated fatty acids, very long chain fatty acid biosynthesis
UniProt: Q9DCS3
Entrez ID: 26922
|
Does Knockout of Tlr8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Tlr8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tlr8 (toll-like receptor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cellular response to mechanical stimulus, defense response to virus, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-12 production, pattern recognition receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of innate immune response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of intracellular signal transduction, positive regulation of type I interferon production, positive regulation of type II interferon production, regulation of cytokine production involved in immune response, response to virus, signal transduction, toll-like receptor 8 signaling pathway, toll-like receptor signaling pathway; MF: DNA binding, double-stranded RNA binding, identical protein binding, pattern recognition receptor activity, protein binding, single-stranded RNA binding; CC: early phagosome, endoplasmic reticulum, endosome, endosome membrane, external side of plasma membrane, lysosome, membrane, plasma membrane
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil extracellular trap formation - Mus musculus (mouse), Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Trafficking and processing of endosomal TLR
UniProt: P58682
Entrez ID: 170744
|
Does Knockout of Sdhc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sdhc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CZB0
Entrez ID: 66052
|
Does Knockout of Defb50 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Defb50
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Defb50 (defensin beta 50)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, defense response, defense response to bacterium; CC: cellular_component, extracellular region
Pathways:
UniProt: Q6TU36
Entrez ID: 387334
|
Does Knockout of Iffo2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Iffo2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Iffo2 (intermediate filament family orphan 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, intermediate filament
Pathways:
UniProt: Q8R2V2
Entrez ID: 212632
|
Does Knockout of Cldn20 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cldn20
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cldn20 (claudin 20)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is identified in retinal pigment epithelium (RPE) and analysis of the RPE transcriptome reveals that this gene expression appears late during development of chick embryo. [provided by RefSeq, Aug 2010].
Gene Ontology:
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt:
Entrez ID: 621628
|
Does Knockout of Agmo in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Agmo
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Agmo (alkylglycerol monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ether lipid metabolic process, lipid biosynthetic process, lipid metabolic process, membrane lipid metabolic process, triglyceride biosynthetic process; MF: glyceryl-ether monooxygenase activity, iron ion binding, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Triglyceride biosynthesis, Triglyceride metabolism
UniProt: Q8BS35
Entrez ID: 319660
|
Does Knockout of Psma7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Psma7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psma7 (proteasome subunit alpha 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z2U0
Entrez ID: 26444
|
Does Knockout of Scrn1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Scrn1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scrn1 (secernin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, proteolysis, regulation of synaptic vesicle cycle; MF: cysteine-type exopeptidase activity, dipeptidase activity, molecular_function; CC: cytoplasm, nuclear membrane, nucleus, presynapse
Pathways:
UniProt: Q9CZC8
Entrez ID: 69938
|
Does Knockout of Trappc6b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,287
|
Knockout
|
Trappc6b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trappc6b (trafficking protein particle complex 6B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi vesicle transport, endoplasmic reticulum to Golgi vesicle-mediated transport, nervous system development, vesicle coating, vesicle tethering; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, cis-Golgi network, cytoplasm, endoplasmic reticulum, trans-Golgi network
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9D289
Entrez ID: 78232
|
Does Knockout of Fam210b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Fam210b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam210b (family with sequence similarity 210, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to estradiol stimulus, erythrocyte differentiation, erythrocyte maturation, inflammatory response, positive regulation of erythrocyte differentiation, reactive oxygen species metabolic process, skin development, spleen development; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q9D8B6
Entrez ID: 67017
|
Does Knockout of Elp5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Elp5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Elp5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell migration, tRNA modification, tRNA processing, tRNA wobble uridine modification; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus
Pathways:
UniProt: Q99L85
Entrez ID: 54351
|
Does Knockout of Cdc16 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Cdc16
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cdc16 (CDC16 cell division cycle 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination; CC: anaphase-promoting complex, centrosome, cytoplasm, mitotic spindle, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8R349
Entrez ID: 69957
|
Does Knockout of Znfx1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Znfx1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Znfx1 (zinc finger, NFX1-type containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, defense response to bacterium, defense response to virus, immune system process, innate immune response, negative regulation of viral genome replication, regulatory ncRNA-mediated heterochromatin formation; MF: RNA binding, helicase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, membrane, mitochondrial outer membrane, mitochondrion, nuclear RNA-directed RNA polymerase complex, nucleus
Pathways:
UniProt: Q8R151
Entrez ID: 98999
|
Does Knockout of Hoxb2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Hoxb2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hoxb2 (homeobox B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, dorsal/ventral pattern formation, embryonic skeletal system morphogenesis, facial nerve structural organization, morphogenesis of an epithelial sheet, neural nucleus development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhombomere 3 development, rhombomere 4 development, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P0C1T1
Entrez ID: 103889
|
Does Knockout of Ctcf in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Ctcf
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ctcf (CCCTC-binding factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, centromeric region, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, dense fibrillar component, granular component, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q61164
Entrez ID: 13018
|
Does Knockout of Ythdf1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ythdf1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ythdf1 (YTH N6-methyladenosine RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, learning, mRNA destabilization, memory, organelle assembly, positive regulation of translation, positive regulation of translational initiation, regulation of antigen processing and presentation, regulation of axon guidance, regulation of long-term synaptic potentiation, regulation of mRNA stability, stress granule assembly; MF: N6-methyladenosine-containing RNA reader activity, RNA binding, mRNA binding, ribosome binding; CC: P-body, cytoplasm, cytoplasmic stress granule
Pathways:
UniProt: P59326
Entrez ID: 228994
|
Does Knockout of Hoxc12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Hoxc12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hoxc12 (homeobox C12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, molecular_function, sequence-specific double-stranded DNA binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q8K5B8
Entrez ID: 15421
|
Does Knockout of Tmem41b in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Tmem41b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem41b (transmembrane protein 41B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, host-mediated perturbation of viral RNA genome replication, intracellular lipid transport, lipid transport, nervous system development, plasma membrane phospholipid scrambling; MF: phospholipid scramblase activity; CC: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site
Pathways:
UniProt: Q8K1A5
Entrez ID: 233724
|
Does Knockout of Nbn in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Nbn
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nbn (nibrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA double-strand break processing, DNA repair, DNA strand resection involved in replication fork processing, R-loop processing, blastocyst growth, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via homologous recombination, homologous recombination, host-mediated suppression of symbiont invasion, immune response, in utero embryonic development, intrinsic apoptotic signaling pathway, isotype switching, meiotic cell cycle, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of neuron differentiation, negative regulation of telomere capping, neuroblast proliferation, neuromuscular process controlling balance, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of telomere maintenance, protection from non-homologous end joining at telomere, protein localization to site of double-strand break, regulation of fibroblast proliferation, t-circle formation, telomere maintenance, telomere maintenance in response to DNA damage, telomere maintenance via telomere trimming, telomeric 3' overhang formation; MF: DNA-binding transcription factor binding, chromatin-protein adaptor activity, damaged DNA binding, histone binding, phosphorylation-dependent protein binding, protein binding, protein serine/threonine kinase activator activity; CC: BRCA1-C complex, Golgi apparatus, Mre11 complex, PML body, chromosomal region, chromosome, chromosome, telomeric region, nuclear inclusion body, nucleolus, nucleoplasm, nucleus, replication fork, site of double-strand break
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Nonhomologous End-Joining (NHEJ), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Sensing of DNA Double Strand Breaks, Transcriptional Regulation by TP53
UniProt: Q9R207
Entrez ID: 27354
|
Does Knockout of Sh3bp5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Sh3bp5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Sh3bp5 (SH3-domain binding protein 5 (BTK-associated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of protein kinase activity; MF: SH3 domain binding, guanyl-nucleotide exchange factor activity, protein kinase inhibitor activity; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, mitochondrion, nuclear body, nucleoplasm
Pathways:
UniProt: Q9Z131
Entrez ID: 24056
|
Does Knockout of Slc25a34 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Slc25a34
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc25a34 (solute carrier family 25, member 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: A2ADF7
Entrez ID: 384071
|
Does Knockout of Satl1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Satl1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Satl1 (spermidine/spermine N1-acetyl transferase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: polyamine metabolic process, spermidine acetylation; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, diamine N-acetyltransferase activity, spermidine binding, transferase activity
Pathways:
UniProt: Q9D5N8
Entrez ID: 73809
|
Does Knockout of Cpsf3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cpsf3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cpsf3 (cleavage and polyadenylation specificity factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: 5'-3' RNA exonuclease activity, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9QXK7
Entrez ID: 54451
|
Does Knockout of Nsun6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Nsun6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nsun6 (NOL1/NOP2/Sun domain family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, methylation, tRNA C5-cytosine methylation, tRNA methylation, tRNA modification; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, tRNA (cytidine-5-)-methyltransferase activity, tRNA binding, transferase activity
Pathways:
UniProt: Q7TS68
Entrez ID: 74455
|
Does Knockout of Phlda3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Phlda3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Phlda3 (pleckstrin homology like domain, family A, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of apoptotic process; MF: phosphatidylinositol phosphate binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-5-phosphate binding; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q9WV95
Entrez ID: 27280
|
Does Knockout of Hs6st2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hs6st2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hs6st2 (heparan sulfate 6-O-sulfotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process; MF: heparan sulfate 6-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q80UW0
Entrez ID: 50786
|
Does Knockout of Ccnk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Ccnk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccnk (cyclin K)
Type: protein-coding
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, in utero embryonic development, negative regulation of stem cell differentiation, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways:
UniProt: Q3U3M5
Entrez ID: 12454
|
Does Knockout of Tm9sf1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Tm9sf1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Tm9sf1 (transmembrane 9 superfamily member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, protein localization to membrane; CC: autophagosome membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q9DBU0
Entrez ID: 74140
|
Does Knockout of Muc13 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Muc13
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Muc13 (mucin 13, epithelial transmembrane)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: apical plasma membrane, cell periphery, cytosol, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, RHO GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Termination of O-glycan biosynthesis
UniProt: P19467
Entrez ID: 17063
|
Does Knockout of Aadat in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Aadat
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Aadat (aminoadipate aminotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, alpha-amino acid metabolic process, glutamate metabolic process, kynurenine metabolic process; MF: 2-aminoadipate transaminase activity, glycine:2-oxoglutarate aminotransferase activity, kynurenine-glyoxylate transaminase activity, kynurenine-oxoglutarate transaminase activity, methionine-glyoxylate transaminase activity, protein homodimerization activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tryptophan catabolism, Tryptophan metabolism - Mus musculus (mouse), lysine degradation II
UniProt: Q9WVM8
Entrez ID: 23923
|
Does Knockout of Bcl2l12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Bcl2l12
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bcl2l12 (BCL2 like 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process; CC: nucleus
Pathways:
UniProt: A0A140LHT8, Q9D3J3, A0A140LHC2, A0A140LIT0
Entrez ID: 75736
|
Does Knockout of Chrd in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Chrd
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Chrd (chordin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, artery morphogenesis, cell population proliferation, central nervous system development, chordate pharynx development, cranial skeletal system development, descending aorta development, dorsal/ventral pattern formation, embryonic axis specification, embryonic heart tube development, epithelial cell fate commitment, exploration behavior, fibroblast growth factor receptor signaling pathway, forebrain development, gastrulation with mouth forming second, gene expression, in utero embryonic development, long-term synaptic potentiation, maintenance of protein location, mesenchymal cell fate commitment, mesoderm formation, negative regulation of BMP signaling pathway, negative regulation of cell migration, negative regulation of osteoblast differentiation, neural crest formation, neuron fate commitment, osteoblast differentiation, pattern specification process, positive regulation of cell adhesion, positive regulation of mesenchymal cell proliferation, presynaptic modulation of chemical synaptic transmission, protein import, regulation of neuronal synaptic plasticity, short-term synaptic potentiation, skeletal system development, smoothened signaling pathway, specification of segmental identity, mandibular segment, spinal cord dorsal/ventral patterning, synapse organization, system development, venous blood vessel morphogenesis, visual learning; MF: BMP binding, heparan sulfate proteoglycan binding, heparin binding, protein binding, syndecan binding; CC: cell surface, extracellular region, extracellular space, presynapse
Pathways: TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q9Z0E2
Entrez ID: 12667
|
Does Knockout of Taf3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Taf3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Taf3 (TATA-box binding protein associated factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, chromatin organization, mRNA transcription by RNA polymerase II, maintenance of protein location in nucleus, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: histone H3K4me3 reader activity, metal ion binding, p53 binding, protein binding, protein heterodimerization activity, transcription regulator inhibitor activity, zinc ion binding; CC: male germ cell nucleus, nuclear membrane, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q5HZG4
Entrez ID: 209361
|
Does Knockout of Nmral1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Nmral1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nmral1 (NmrA-like family domain containing 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and lung. Orthologous to human NMRAL1 (NmrA like redox sensor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Metabolism, Metabolism of amino acids and derivatives, Urea cycle
UniProt: Q8K2T1
Entrez ID: 67824
|
Does Knockout of Rnf207 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rnf207
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rnf207 (ring finger protein 207)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of gene expression, positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential, regulation of cardiac muscle contraction, regulation of heart looping; MF: Hsp70 protein binding, metal ion binding, protein-folding chaperone binding, transmembrane transporter binding, zinc ion binding; CC: cytoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: Q3V3A7
Entrez ID: 433809
|
Does Knockout of Tlr7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tlr7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tlr7 (toll-like receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, canonical NF-kappaB signal transduction, cellular response to mechanical stimulus, cellular response to virus, defense response to virus, immune system process, inflammatory response, innate immune response, pattern recognition receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine production, positive regulation of inflammatory response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of intracellular signal transduction, positive regulation of macrophage cytokine production, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, positive regulation of type II interferon production, regulation of cytokine production involved in immune response, response to cGMP, signal transduction, toll-like receptor 7 signaling pathway, toll-like receptor 8 signaling pathway, toll-like receptor signaling pathway; MF: double-stranded RNA binding, pattern recognition receptor activity, protein binding, siRNA binding, single-stranded RNA binding; CC: cytoplasm, cytoplasmic vesicle, early phagosome, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, lysosome, membrane, phagocytic vesicle, plasma membrane, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Measles - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Regulation of TLR by endogenous ligand, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Trafficking and processing of endosomal TLR
UniProt: P58681
Entrez ID: 170743
|
Does Knockout of Aldh1a2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Aldh1a2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Aldh1a2 (aldehyde dehydrogenase family 1, subfamily A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, aldehyde metabolic process, anterior/posterior pattern specification, blood vessel development, camera-type eye development, cardiac muscle tissue development, cellular response to retinoic acid, determination of bilateral symmetry, embryonic camera-type eye development, embryonic digestive tract development, embryonic forelimb morphogenesis, embryonic limb morphogenesis, face development, forebrain development, heart development, heart looping, heart morphogenesis, hindbrain development, kidney development, lipid metabolic process, liver development, lung development, midgut development, morphogenesis of embryonic epithelium, negative regulation of cell population proliferation, neural crest cell development, neural tube development, neuron differentiation, pancreas development, pituitary gland development, positive regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of gene expression, protein homotetramerization, proximal/distal pattern formation, regulation of vascular endothelial cell proliferation, response to cytokine, response to estradiol, response to retinoic acid, response to vitamin A, retinal metabolic process, retinoic acid biosynthetic process, retinoic acid metabolic process, retinoic acid receptor signaling pathway, retinoid metabolic process, retinol metabolic process, somitogenesis, ureter maturation; MF: 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD+) activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, retinal binding, retinal dehydrogenase (NAD+) activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways: RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid
UniProt: Q62148
Entrez ID: 19378
|
Does Knockout of Spock2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Spock2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Spock2 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, extracellular matrix organization, positive regulation of cell-substrate adhesion; MF: calcium ion binding, collagen binding, extracellular matrix binding, extracellular matrix structural constituent conferring compression resistance, glycosaminoglycan binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q9ER58
Entrez ID: 94214
|
Does Knockout of Flot2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Flot2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Flot2 (flotillin 2)
Type: protein-coding
Summary: Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in anterograde dendritic transport; regulation of myoblast differentiation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in acrosomal membrane and caveola. Part of flotillin complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterograde dendritic transport, cell adhesion, negative regulation of amyloid precursor protein catabolic process, negative regulation of gene expression, positive regulation of canonical NF-kappaB signal transduction, positive regulation of establishment of T cell polarity, protein localization to plasma membrane, protein localization to plasma membrane raft, protein stabilization, regulation of myoblast differentiation, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: ionotropic glutamate receptor binding, protease binding; CC: acrosomal membrane, adherens junction, basolateral plasma membrane, caveola, cell-cell contact zone, cortical actin cytoskeleton, cytoplasmic vesicle, dendrite cytoplasm, endocytic vesicle, endosome, flotillin complex, glutamatergic synapse, lamellipodium, membrane, membrane raft, perinuclear region of cytoplasm, plasma membrane, presynaptic active zone membrane, synapse, uropod, vesicle
Pathways: Insulin signaling pathway - Mus musculus (mouse)
UniProt: Q60634
Entrez ID: 14252
|
Does Knockout of Mrpl30 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Mrpl30
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mrpl30 (mitochondrial ribosomal protein L30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: molecular_function, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D7N6
Entrez ID: 107734
|
Does Knockout of Irx2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Irx2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Irx2 (Iroquois homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell development, metanephros development, negative regulation of transcription by RNA polymerase II, neuron differentiation, proximal/distal pattern formation involved in metanephric nephron development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, specification of loop of Henle identity; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P81066
Entrez ID: 16372
|
Does Knockout of Sp110 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Sp110
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sp110 (Sp110 nuclear body protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, immune system process, innate immune response, positive regulation of apoptotic process, regulation of transcription by RNA polymerase II, response to bacterium; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8BVK9
Entrez ID: 109032
|
Does Knockout of Gm3604 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gm3604
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gm3604 (predicted gene 3604)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: A0A0J9YU77, A0A087WPN2, D3YUB7
Entrez ID: 100041979
|
Does Knockout of Nkx6-1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Nkx6-1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nkx6-1 (NK6 homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to cytokine stimulus, cellular response to peptide hormone stimulus, central nervous system neuron differentiation, endocrine pancreas development, enteroendocrine cell differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of transcription by RNA polymerase II, neurogenesis, oligodendrocyte differentiation, pancreatic A cell differentiation, positive regulation of insulin secretion, positive regulation of neuron differentiation, positive regulation of oligodendrocyte differentiation, regulation of DNA-templated transcription, regulation of axon extension, regulation of neuron migration, regulation of transcription by RNA polymerase II, response to nicotine, response to xenobiotic stimulus, smoothened signaling pathway, spinal cord motor neuron cell fate specification, transcription by RNA polymerase II, type B pancreatic cell development, type B pancreatic cell differentiation, type B pancreatic cell proliferation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific DNA binding; CC: cytosol, nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: Q99MA9
Entrez ID: 18096
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.