prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Arsj in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Arsj
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arsj (arylsulfatase J)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: actin cytoskeleton, extracellular region
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases, chondroitin sulfate degradation (metazoa)
UniProt: Q8BM89
Entrez ID: 271970
|
Does Knockout of Zscan26 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Zscan26
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zscan26 (zinc finger and SCAN domain containing 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q5RJ54
Entrez ID: 432731
|
Does Knockout of Banf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Banf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Banf1 (BAF nuclear assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA integration, DNA repair, cGAS/STING signaling pathway, chromatin organization, chromosome organization, establishment of integrated proviral latency, mitotic nuclear membrane reassembly, negative regulation of cGAS/STING signaling pathway, negative regulation of innate immune response, negative regulation of protein ADP-ribosylation, negative regulation of type I interferon production, negative regulation of viral genome replication, positive regulation of type I interferon production, response to oxidative stress; MF: DNA binding, double-stranded DNA binding, identical protein binding, protein homodimerization activity; CC: chromatin, chromosome, condensed chromosome, cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown
UniProt: O54962
Entrez ID: 23825
|
Does Knockout of Trim62 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Trim62
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim62 (tripartite motif-containing 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of epithelial to mesenchymal transition, negative regulation of viral transcription, positive regulation of DNA-templated transcription, positive regulation of antifungal innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein K27-linked ubiquitination, protein ubiquitination, regulation of viral entry into host cell, viral release from host cell; MF: identical protein binding, metal ion binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q80V85
Entrez ID: 67525
|
Does Knockout of Pfkfb2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Pfkfb2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pfkfb2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate phosphorylation, fructose 2,6-bisphosphate metabolic process, fructose metabolic process, gluconeogenesis, glucose catabolic process, glycolytic process, glycolytic process through fructose-6-phosphate, lactate biosynthetic process, positive regulation of insulin secretion, pyruvate biosynthetic process, response to glucose; MF: 6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity, kinase activity, kinase binding, nucleotide binding, protein kinase binding, transferase activity; CC: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex, cytosol, nucleoplasm
Pathways: AMPK signaling pathway - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Glucose metabolism, Glycolysis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: P70265
Entrez ID: 18640
|
Does Knockout of Ablim3 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Ablim3
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Ablim3 (actin binding LIM protein family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, cytoskeleton organization, lamellipodium assembly, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: actin binding, actin filament binding, metal ion binding; CC: actin cytoskeleton, cytoplasm, glutamatergic synapse, lamellipodium, stress fiber, synapse
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q69ZX8
Entrez ID: 319713
|
Does Knockout of Rbm34 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Rbm34
|
phagocytosis
|
macrophage
|
Gene: Rbm34 (RNA binding motif protein 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, molecular_function, nucleic acid binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8C5L7
Entrez ID: 52202
|
Does Knockout of Tbc1d10c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tbc1d10c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tbc1d10c (TBC1 domain family, member 10c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of B cell activation, negative regulation of ERK1 and ERK2 cascade, negative regulation of calcineurin-NFAT signaling cascade, retrograde transport, endosome to Golgi; MF: GTPase activator activity; CC: cytosol, filopodium membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Membrane Trafficking, Neutrophil degranulation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q8C9V1
Entrez ID: 108995
|
Does Knockout of Wnt4 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Wnt4
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Wnt4 (wingless-type MMTV integration site family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell differentiation, T cell differentiation in thymus, Wnt signaling pathway, adrenal gland development, animal organ morphogenesis, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, canonical Wnt signaling pathway, cell fate commitment, cell-cell signaling, cellular response to starvation, cellular response to transforming growth factor beta stimulus, embryonic epithelial tube formation, epithelial to mesenchymal transition, female gonad development, female sex determination, gamete generation, hormone metabolic process, immature T cell proliferation in thymus, kidney development, kidney morphogenesis, liver development, male gonad development, mammary gland epithelium development, mesenchymal to epithelial transition, mesonephric tubule development, mesonephros development, metanephric mesenchymal cell differentiation, metanephric nephron development, metanephric nephron morphogenesis, metanephric tubule formation, metanephros development, negative regulation of DNA-templated transcription, negative regulation of Ras protein signal transduction, negative regulation of androgen biosynthetic process, negative regulation of apoptotic signaling pathway, negative regulation of cell differentiation, negative regulation of cell migration, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of male gonad development, negative regulation of steroid biosynthetic process, negative regulation of testicular blood vessel morphogenesis, negative regulation of testosterone biosynthetic process, negative regulation of wound healing, nephron development, neuron differentiation, non-canonical Wnt signaling pathway, oocyte development, paramesonephric duct development, pericyte cell differentiation, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of aldosterone biosynthetic process, positive regulation of bone mineralization, positive regulation of collagen biosynthetic process, positive regulation of cortisol biosynthetic process, positive regulation of dermatome development, positive regulation of focal adhesion assembly, positive regulation of meiotic nuclear division, positive regulation of osteoblast differentiation, positive regulation of stress fiber assembly, regulation of cell-cell adhesion, renal vesicle formation, renal vesicle induction, sex differentiation, signal transduction, smooth muscle cell differentiation, somatotropin secreting cell differentiation, tertiary branching involved in mammary gland duct morphogenesis, thyroid-stimulating hormone-secreting cell differentiation, tube morphogenesis; MF: cytokine activity, frizzled binding, protein binding, receptor ligand activity, signaling receptor binding, transcription corepressor activity; CC: cell surface, cytoplasm, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular space
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), WNT ligand biogenesis and trafficking, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P22724
Entrez ID: 22417
|
Does Knockout of Coq8b in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Coq8b
|
cell cycle progression
|
breast epithelium
|
Gene: Coq8b (coenzyme Q8B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar Purkinje cell layer morphogenesis, protein phosphorylation, ubiquinone biosynthetic process; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, transferase activity; CC: cytoplasm, cytosol, membrane, mitochondrial membrane, mitochondrion, plasma membrane
Pathways:
UniProt: A0A0R4J1X1, E9QLB8
Entrez ID: 76889
|
Does Knockout of Fuom in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Fuom
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fuom (fucose mutarotase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-L-fucose salvage, female mating behavior, fucose metabolic process, fucosylation, monosaccharide metabolic process, negative regulation of neuron differentiation; MF: L-fucose mutarotase activity, fucose binding, isomerase activity, monosaccharide binding, racemase and epimerase activity, acting on carbohydrates and derivatives; CC: cytosol
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, GDP-fucose biosynthesis, Metabolism of proteins, Post-translational protein modification, Synthesis of substrates in N-glycan biosythesis
UniProt: Q8R2K1
Entrez ID: 69064
|
Does Knockout of Slamf6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Slamf6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slamf6 (SLAM family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T-helper 17 cell lineage commitment, adaptive immune response, immune response, immune system process, innate immune response, natural killer cell differentiation, natural killer cell proliferation, positive regulation of interleukin-17 production, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of type II interferon production; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q9ET39
Entrez ID: 30925
|
Does Knockout of Sim1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Sim1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sim1 (single-minded family bHLH transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, nervous system development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, system development, ureteric bud development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, protein heterodimerization activity; CC: nucleus
Pathways:
UniProt: Q61045
Entrez ID: 20464
|
Does Knockout of Cep72 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Cep72
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cep72 (centrosomal protein 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, gamma-tubulin complex localization, regulation of protein localization to centrosome, spindle organization; CC: centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9D3R3
Entrez ID: 74470
|
Does Knockout of Cd200r3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cd200r3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cd200r3 (CD200 receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q5UKY4
Entrez ID: 74603
|
Does Knockout of Zfp786 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Zfp786
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp786 (zinc finger protein 786)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BV42
Entrez ID: 330301
|
Does Knockout of Unc45b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Unc45b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Unc45b (unc-45 myosin chaperone B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, lens development in camera-type eye, muscle organ development, protein folding; MF: Hsp90 protein binding; CC: A band, Z disc, cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways:
UniProt: Q8CGY6
Entrez ID: 217012
|
Does Knockout of Plec in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Plec
|
cell cycle progression
|
breast epithelium
|
Gene: Plec (plectin)
Type: protein-coding
Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: T cell chemotaxis, actin cytoskeleton organization, actin filament organization, actomyosin contractile ring assembly actin filament organization, adherens junction organization, cardiac muscle cell development, cell morphogenesis, cell motility, cellular response to fluid shear stress, cellular response to hydrostatic pressure, cellular response to mechanical stimulus, epithelial cell differentiation, establishment of skin barrier, fibroblast migration, gene expression, hemidesmosome assembly, intermediate filament cytoskeleton organization, intermediate filament organization, intracellular protein localization, keratinocyte development, keratinocyte differentiation, leukocyte migration involved in immune response, mitochondrion organization, multicellular organism growth, myelination in peripheral nervous system, myoblast differentiation, nucleus organization, peripheral nervous system myelin maintenance, protein-containing complex organization, regulation of vascular permeability, respiratory electron transport chain, response to food, response to nutrient, response to nutrient levels, sarcomere organization, skeletal muscle fiber development, skeletal muscle tissue development, skeletal myofibril assembly, skin development, tight junction organization, transmission of nerve impulse, wound healing; MF: actin binding, actin filament binding, ankyrin binding, cytoskeletal protein binding, dystroglycan binding, identical protein binding, protein binding, structural constituent of cytoskeleton, structural constituent of muscle; CC: Z disc, anchoring junction, apical plasma membrane, axon, basal plasma membrane, brush border, cell periphery, cell projection, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, dendrite, focal adhesion, hemidesmosome, intermediate filament, intermediate filament cytoskeleton, mitochondrial outer membrane, myelin sheath, myofibril, perinuclear region of cytoplasm, podosome, sarcolemma, sarcoplasm
Pathways:
UniProt: Q9QXS1
Entrez ID: 18810
|
Does Knockout of Vdac3-ps1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Vdac3-ps1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Vdac3-ps1 (voltage-dependent anion channel 3, pseudogene 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nub1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Nub1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nub1 (negative regulator of ubiquitin-like proteins 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, protein ubiquitination, proteolysis involved in protein catabolic process, regulation of ubiquitin-dependent protein catabolic process, response to tumor necrosis factor, response to type II interferon, ubiquitin-dependent protein catabolic process; CC: Lewy body, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P54729
Entrez ID: 53312
|
Does Knockout of Mir680-2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mir680-2
|
cell cycle progression
|
breast epithelium
|
Gene: Mir680-2 (microRNA 680-2)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, response to muscle activity
Pathways:
UniProt:
Entrez ID: 751551
|
Does Knockout of Krt8 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Krt8
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Krt8 (keratin 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation involved in embryonic placenta development, extrinsic apoptotic signaling pathway, hepatocyte apoptotic process, response to hydrostatic pressure, response to other organism, sarcomere organization, tumor necrosis factor-mediated signaling pathway; MF: protein binding, protein-containing complex binding, scaffold protein binding; CC: Z disc, apicolateral plasma membrane, cell periphery, cell-cell junction, costamere, cytoplasm, dystrophin-associated glycoprotein complex, intermediate filament, intermediate filament cytoskeleton, keratin filament, nuclear matrix, nucleoplasm, nucleus, sarcolemma
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P11679
Entrez ID: 16691
|
Does Knockout of Actr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Actr2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Actr2 (actin related protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of dendritic spine morphogenesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, cytoskeletal protein binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium, nucleus, podosome core, postsynapse, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P61161
Entrez ID: 66713
|
Does Knockout of Pcyt1a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Pcyt1a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcyt1a (phosphate cytidylyltransferase 1, choline, alpha isoform)
Type: protein-coding
Summary: Enables choline-phosphate cytidylyltransferase activity. Involved in B cell proliferation; CDP-choline pathway; and isotype switching. Located in endoplasmic reticulum membrane and glycogen granule. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell proliferation, CDP-choline pathway, isotype switching, lipid metabolic process, phosphatidylcholine biosynthetic process, phospholipid biosynthetic process; MF: calmodulin binding, catalytic activity, choline-phosphate cytidylyltransferase activity, identical protein binding, lipid binding, molecular function inhibitor activity, nucleotidyltransferase activity, phosphatidylcholine binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, glycogen granule, membrane, nuclear envelope, nucleus
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Mus musculus (mouse), Synthesis of PC, choline biosynthesis III, phosphatidylcholine biosynthesis I
UniProt: P49586
Entrez ID: 13026
|
Does Knockout of Zfp981 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zfp981
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp981 (zinc finger protein 981)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: A2A8V6, A2A8V7
Entrez ID: 100041433
|
Does Knockout of Acd in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Acd
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Acd (adrenocortical dysplasia)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic limb morphogenesis, establishment of protein localization to telomere, intracellular protein transport, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protection from non-homologous end joining at telomere, protein localization to chromosome, telomeric region, regulation of establishment of protein localization to telomere, segmentation, skeletal system development, telomere assembly, telomere capping, telomere maintenance, telomere maintenance via telomerase, urogenital system development; MF: DNA binding, DNA polymerase binding, protein binding, protein-containing complex binding, telomerase inhibitor activity, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, shelterin complex, telomerase holoenzyme complex
Pathways: Base Excision Repair, Base-Excision Repair, AP Site Formation, Cell Cycle, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, Cleavage of the damaged purine, DNA Damage/Telomere Stress Induced Senescence, DNA Repair, Depurination, Extension of Telomeres, Inhibition of DNA recombination at telomere, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Removal of the Flap Intermediate from the C-strand, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q5EE38
Entrez ID: 497652
|
Does Knockout of Pfas in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Pfas
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, anterior head development, glutamine metabolic process, purine nucleotide biosynthetic process, response to xenobiotic stimulus; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, phosphoribosylformylglycinamidine synthase activity; CC: cytoplasm
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis
UniProt: Q5SUR0
Entrez ID: 237823
|
Does Knockout of Rpe65 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rpe65
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rpe65 (retinal pigment epithelium 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, circadian rhythm, detection of light stimulus involved in visual perception, lipid metabolic process, neural retina development, response to light stimulus, retina homeostasis, retinal metabolic process, retinoid metabolic process, retinol metabolic process, visual perception, zeaxanthin biosynthetic process; MF: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, beta-carotene 15,15'-dioxygenase activity, cardiolipin binding, hydrolase activity, isomerase activity, metal ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, phosphatidylcholine binding, phosphatidylserine binding, protein binding, retinol isomerase activity; CC: cell body, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, plasma membrane
Pathways: Retinol metabolism - Mus musculus (mouse), Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q91ZQ5
Entrez ID: 19892
|
Does Knockout of Sap18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sap18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sap18 (Sin3-associated polypeptide 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: protein binding, transcription corepressor activity; CC: ASAP complex, cytoplasm, cytosol, exon-exon junction complex, histone deacetylase complex, nuclear body, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O55128
Entrez ID: 20220
|
Does Knockout of Tbx4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Tbx4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tbx4 (T-box 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell fate specification, developmental process, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, embryonic lung development, limb morphogenesis, lung development, morphogenesis of an epithelium, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: chromatin, nucleus
Pathways:
UniProt: P70325
Entrez ID: 21387
|
Does Knockout of Cspp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Cspp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cspp1 (centrosome and spindle pole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell division, positive regulation of cytokinesis; CC: cell projection, centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule, nucleoplasm, spindle, spindle pole
Pathways:
UniProt: B2RX88
Entrez ID: 211660
|
Does Knockout of Rdh16 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rdh16
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rdh16 (retinol dehydrogenase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, androgen biosynthetic process, lipid metabolic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process; MF: 11-cis-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, identical protein binding, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, organelle membrane
Pathways: Retinol metabolism - Mus musculus (mouse)
UniProt: O54909
Entrez ID: 19683
|
Does Knockout of Myo1c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Myo1c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Myo1c (myosin IC)
Type: protein-coding
Summary: This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament organization, actin filament-based movement, cellular response to type II interferon, chromatin remodeling, endocytosis, positive regulation of actin filament polymerization, positive regulation of cell migration, positive regulation of cellular response to insulin stimulus, positive regulation of protein targeting to membrane, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, protein targeting to membrane, regulation of bicellular tight junction assembly, vascular endothelial growth factor signaling pathway, vesicle transport along actin filament; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding, phospholipid binding, protein binding, signaling receptor binding, small GTPase binding; CC: B-WICH complex, actin cytoskeleton, basal plasma membrane, brush border, cell cortex, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, filamentous actin, lateral plasma membrane, membrane, membrane raft, microvillus, myosin complex, nuclear body, nucleolus, nucleoplasm, nucleus, phagocytic vesicle, plasma membrane, plasma membrane bounded cell projection, ruffle membrane, stereocilium, stereocilium bundle, stereocilium membrane
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Fcgamma receptor (FCGR) dependent phagocytosis, Gene expression (Transcription), Immune System, Innate Immune System, Positive epigenetic regulation of rRNA expression, Regulation of actin dynamics for phagocytic cup formation
UniProt: Q9WTI7
Entrez ID: 17913
|
Does Knockout of Mbl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mbl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mbl1 (mannose-binding lectin (protein A) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: complement activation, classical pathway, complement activation, lectin pathway, defense response to Gram-positive bacterium, immune system process, innate immune response, killing by host of symbiont cells, positive regulation of phagocytosis, protein homotrimerization, surfactant homeostasis; MF: D-mannose binding, calcium ion binding, calcium-dependent carbohydrate binding, calcium-dependent protein binding, carbohydrate binding, identical protein binding, metal ion binding, oligosaccharide binding, phosphatidylinositol-4-phosphate binding, polysaccharide binding, protease binding, protein homodimerization activity; CC: collagen trimer, extracellular region, extracellular space, multivesicular body
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P39039
Entrez ID: 17194
|
Does Knockout of Vmn2r52 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Vmn2r52
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Vmn2r52 (vomeronasal 2, receptor 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WCG3, L7N2B2
Entrez ID: 384534
|
Does Knockout of Lcn12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Lcn12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lcn12 (lipocalin 12)
Type: protein-coding
Summary: Predicted to enable retinoic acid binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human LCN12 (lipocalin 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: molecular_function, retinoic acid binding, small molecule binding; CC: extracellular region, extracellular space
Pathways: SLC-mediated transmembrane transport, Transport of fatty acids, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q6JVL5
Entrez ID: 77701
|
Does Knockout of B3galt1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
B3galt1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: B3galt1 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: galactosylceramide biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O54904
Entrez ID: 26877
|
Does Knockout of Foxe1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Foxe1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Foxe1 (forkhead box E1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cranial skeletal system development and roof of mouth development. Acts upstream of or within several processes, including hair follicle morphogenesis; thyroid gland development; and thyroid hormone generation. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial pouch endoderm; head surface ectoderm; and outflow tract. Used to study Bamforth-Lazarus syndrome and congenital hypothyroidism. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and papillary thyroid carcinoma. Orthologous to human FOXE1 (forkhead box E1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anatomical structure morphogenesis, animal organ development, cell differentiation, cell migration, cellular response to insulin stimulus, chordate pharynx development, cranial skeletal system development, embryonic organ morphogenesis, hair follicle morphogenesis, hard palate development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, roof of mouth development, soft palate development, system development, thymus development, thyroid gland development, thyroid hormone generation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q8R2I0
Entrez ID: 110805
|
Does Knockout of Med14 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Med14
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Med14 (mediator complex subunit 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: A2ABV5
Entrez ID: 26896
|
Does Knockout of Tagln in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tagln
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tagln (transgelin)
Type: protein-coding
Summary: This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: epithelial cell differentiation
Pathways:
UniProt: P37804
Entrez ID: 21345
|
Does Knockout of Enpp5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Enpp5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Enpp5 (ectonucleotide pyrophosphatase/phosphodiesterase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, nucleotide catabolic process; MF: NAD+ diphosphatase activity, dinucleotide phosphatase activity, hydrolase activity, metal ion binding, zinc ion binding; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q9EQG7
Entrez ID: 83965
|
Does Knockout of Rnf185 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Rnf185
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rnf185 (ring finger protein 185)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, autophagy, cGAS/STING signaling pathway, defense response to virus, immune system process, innate immune response, positive regulation of ERAD pathway, positive regulation of innate immune response, positive regulation of type I interferon-mediated signaling pathway, protein K27-linked ubiquitination, protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein-containing complex binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-like protein conjugating enzyme binding, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Immune System, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q91YT2
Entrez ID: 193670
|
Does Knockout of Wnk4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Wnk4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Wnk4 (WNK lysine deficient protein kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, aldosterone secretion, calcium ion homeostasis, cellular response to xenobiotic stimulus, chloride transport, distal tubule morphogenesis, gene expression, inflammatory response, intracellular chloride ion homeostasis, intracellular protein localization, intracellular signal transduction, macrophage activation, monoatomic ion homeostasis, negative regulation of pancreatic juice secretion, negative regulation of protein localization to plasma membrane, negative regulation of sodium ion transport, positive regulation of potassium ion import across plasma membrane, potassium ion transmembrane transport, protein phosphorylation, regulation of blood pressure, regulation of metal ion transport, regulation of potassium ion export across plasma membrane, renal sodium ion absorption, renal sodium ion transport, response to dietary excess, response to xenobiotic stimulus, signal transduction, sodium ion transmembrane transport; MF: ATP binding, chloride ion binding, ion channel inhibitor activity, kinase activity, nucleotide binding, potassium channel inhibitor activity, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: anchoring junction, bicellular tight junction, cell body, cytoplasm, cytosol, membrane, protein-containing complex
Pathways:
UniProt: Q80UE6
Entrez ID: 69847
|
Does Knockout of Lpar1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Lpar1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lpar1 (lysophosphatidic acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi to plasma membrane protein transport, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bleb assembly, cell chemotaxis, cellular response to 1-oleoyl-sn-glycerol 3-phosphate, cellular response to oxygen levels, cerebellum development, corpus callosum development, myelination, negative regulation of cAMP/PKA signal transduction, negative regulation of cilium assembly, negative regulation of neuron projection development, neurogenesis, oligodendrocyte development, optic nerve development, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of Rho protein signal transduction, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cilium assembly, positive regulation of dendritic spine development, positive regulation of smooth muscle cell chemotaxis, positive regulation of stress fiber assembly, protein localization to cilium, regulation of cell shape, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synaptic vesicle cycle, regulation of vesicle-mediated transport, signal transduction; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, PDZ domain binding, lysophosphatidic acid binding, lysophosphatidic acid receptor activity, phospholipid binding, protein binding; CC: GABA-ergic synapse, cell surface, cytoplasm, dendritic shaft, dendritic spine, endocytic vesicle, endosome, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Lysosphingolipid and LPA receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P61793
Entrez ID: 14745
|
Does Knockout of Vmn1r199 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Vmn1r199
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r199 (vomeronasal 1 receptor 199)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQB1, Q8R280
Entrez ID: 171247
|
Does Knockout of Rbp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Rbp2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbp2 (retinol binding protein 2, cellular)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid transport, retinoid metabolic process, triglyceride biosynthetic process; MF: binding, enzyme-substrate adaptor activity, fatty acid binding, lipid binding, molecular carrier activity, retinal binding, retinoid binding, retinol binding, transmembrane transporter binding; CC: cytoplasm, cytosol, nucleus, synaptic ribbon
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q08652
Entrez ID: 19660
|
Does Knockout of Zfp763 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zfp763
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zfp763 (zinc finger protein 763)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q8BIC7
Entrez ID: 73451
|
Does Knockout of Cd300e in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cd300e
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cd300e (CD300E molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, immune system process, regulation of innate immune response, signal transduction; MF: molecular_function, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, DAP12 interactions, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System
UniProt: Q8K249
Entrez ID: 217306
|
Does Knockout of Grb7 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Grb7
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Grb7 (growth factor receptor bound protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of cell migration, signal transduction, stress granule assembly; MF: RNA binding, identical protein binding, lipid binding, phosphatidylinositol binding, protein binding, protein kinase binding; CC: anchoring junction, cell projection, cytoplasm, cytoplasmic stress granule, cytosol, focal adhesion, membrane, plasma membrane
Pathways: Axon guidance, Cell surface interactions at the vascular wall, Developmental Biology, Downstream signal transduction, GRB7 events in ERBB2 signaling, Hemostasis, Nervous system development, RET signaling, RHO GTPase cycle, RND1 GTPase cycle, Signal Transduction, Signaling by ERBB2, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Tie2 Signaling
UniProt: Q03160
Entrez ID: 14786
|
Does Knockout of Tppp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Tppp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tppp (tubulin polymerization promoting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astral microtubule organization, cell division, microtubule bundle formation, microtubule nucleation by microtubule organizing center, microtubule polymerization, myelin assembly, negative regulation of tubulin deacetylation, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of myelination, positive regulation of protein polymerization, positive regulation of protein-containing complex assembly, regulation of microtubule cytoskeleton organization; MF: GTPase activity, hydrolase activity, magnesium ion binding, metal ion binding, microtubule binding, protein homodimerization activity, tubulin binding; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, microtubule, microtubule bundle, microtubule organizing center, mitochondrion, mitotic spindle, myelin sheath, nucleus, perinuclear region of cytoplasm, postsynaptic Golgi apparatus, spindle
Pathways:
UniProt: Q7TQD2
Entrez ID: 72948
|
Does Knockout of Nedd1 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,412
|
Knockout
|
Nedd1
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Nedd1 (neural precursor cell expressed, developmentally down-regulated gene 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule depolymerization, microtubule nucleation, microtubule polymerization or depolymerization, mitotic cell cycle, regulation of establishment of protein localization; CC: apical part of cell, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, fibrillar center, gamma-tubulin ring complex, nucleoplasm, pericentriolar material, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P33215
Entrez ID: 17997
|
Does Knockout of Gm773 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gm773
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gm773 (predicted gene 773)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome reaction, meiotic cell cycle, penetration of zona pellucida, sperm DNA condensation, spermatid development; CC: nucleus, synaptonemal complex
Pathways:
UniProt: Q3TML4
Entrez ID: 331416
|
Does Knockout of Nos2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Nos2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nos2 (nitric oxide synthase 2, inducible)
Type: protein-coding
Summary: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, L-arginine catabolic process, blood vessel remodeling, cGMP-mediated signaling, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to type II interferon, cellular response to xenobiotic stimulus, circadian rhythm, defense response to bacterium, inflammatory response, intracellular signal transduction, negative regulation of blood pressure, negative regulation of gene expression, negative regulation of protein catabolic process, nitric oxide biosynthetic process, nitric oxide mediated signal transduction, peptidyl-cysteine S-nitrosylation, positive regulation of apoptotic process, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, prostaglandin secretion, regulation of blood pressure, regulation of cell population proliferation, regulation of cytokine production involved in inflammatory response, regulation of insulin secretion, response to bacterium, response to hormone, response to hypoxia, response to lipopolysaccharide, response to tumor necrosis factor, superoxide metabolic process; MF: FMN binding, Hsp90 protein binding, NADP binding, actin binding, arginine binding, beta-catenin binding, cAMP-dependent protein kinase regulator activity, cadherin binding, calmodulin binding, flavin adenine dinucleotide binding, heme binding, identical protein binding, metal ion binding, nitric-oxide synthase activity, nitric-oxide synthase binding, oxidoreductase activity, protein binding, protein homodimerization activity, protein kinase binding, tetrahydrobiopterin binding; CC: cortical cytoskeleton, cytoplasm, cytosol, extracellular space, nucleus, perinuclear region of cytoplasm, peroxisome, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Immune System, Innate Immune System, Leishmaniasis - Mus musculus (mouse), Nitric oxide stimulates guanylate cyclase, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Platelet homeostasis, Protein localization, ROS and RNS production in phagocytes, Relaxin signaling pathway - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), citrulline-nitric oxide cycle, superpathway of citrulline metabolism
UniProt: P29477
Entrez ID: 18126
|
Does Knockout of Ap4b1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ap4b1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ap4b1 (adaptor-related protein complex AP-4, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, protein localization to somatodendritic compartment, protein targeting, protein transport, vesicle-mediated transport; MF: clathrin binding, protein binding; CC: AP-4 adaptor complex, Golgi apparatus, clathrin adaptor complex, cytoplasmic side of trans-Golgi network transport vesicle membrane, cytosol, membrane, membrane coat, trans-Golgi network
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9WV76
Entrez ID: 67489
|
Does Knockout of Got1l1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Got1l1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Got1l1 (glutamic-oxaloacetic transaminase 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid metabolic process, aspartate biosynthetic process; MF: L-aspartate:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: 4-hydroxyproline degradation I, Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), L-cysteine degradation I, Phenylalanine metabolism - Mus musculus (mouse), Phenylalanine, tyrosine and tryptophan biosynthesis - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), superpathway of methionine degradation
UniProt: Q7TSV6
Entrez ID: 76615
|
Does Knockout of Wipi2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Wipi2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Wipi2 (WD repeat domain, phosphoinositide interacting 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, autophagy of mitochondrion, cellular response to starvation, glycophagy, nucleophagy, pexophagy, protein localization to phagophore assembly site, response to stress, xenophagy; MF: lipid binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-5-phosphate binding, protein binding, protein-macromolecule adaptor activity; CC: autophagosome, cytosol, membrane, nucleoplasm, phagophore assembly site, phagophore assembly site membrane, protein-containing complex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Macroautophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q80W47
Entrez ID: 74781
|
Does Knockout of Smpd3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Smpd3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Smpd3 (sphingomyelin phosphodiesterase 3, neutral)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA biosynthetic process, G1 to G0 transition, artery smooth muscle contraction, bone development, bone growth, bone mineralization, cartilage development, cellular response to hydrogen peroxide, cellular response to magnesium ion, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to peptide, cellular response to reactive oxygen species, cellular response to redox state, cellular response to tumor necrosis factor, ceramide metabolic process, chondrocyte development, chondrocyte development involved in endochondral bone morphogenesis, collagen metabolic process, dentinogenesis, dopamine uptake, endochondral ossification, extracellular matrix assembly, hematopoietic progenitor cell differentiation, lipid metabolic process, lung alveolus development, lung development, mitotic nuclear division, multicellular organism growth, negative regulation of cytosolic calcium ion concentration, negative regulation of hyaluronan biosynthetic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, ossification, peptide hormone secretion, platelet-derived growth factor receptor signaling pathway, polysaccharide transport, positive regulation of ceramide biosynthetic process, positive regulation of exosomal secretion, positive regulation of mitotic nuclear division, positive regulation of nitric oxide biosynthetic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of smooth muscle cell proliferation, regulation of cartilage development, regulation of hyaluronan biosynthetic process, regulation of leukocyte migration, respiratory system development, signal transduction, skeletal system development, sphingolipid mediated signaling pathway, sphingolipid metabolic process, sphingomyelin catabolic process, sphingomyelin metabolic process; MF: catalytic activity, hydrolase activity, identical protein binding, metal ion binding, neutral sphingomyelin phosphodiesterase activity, phosphatidic acid binding, phosphatidylserine binding, phosphoric diester hydrolase activity, protein binding, sphingomyelin phosphodiesterase activity; CC: Golgi apparatus, Golgi cis cisterna, Golgi membrane, cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Death Receptor Signaling, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Signal Transduction, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), TNF signaling, TNFR1-mediated ceramide production, sphingomyelin metabolism
UniProt: Q9JJY3
Entrez ID: 58994
|
Does Knockout of C130074G19Rik in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
C130074G19Rik
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: C130074G19Rik (RIKEN cDNA C130074G19 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of response to drug; CC: 9+0 non-motile cilium, membrane
Pathways:
UniProt: Q8BGN9
Entrez ID: 226777
|
Does Knockout of Dclre1c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Dclre1c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dclre1c (DNA cross-link repair 1C)
Type: protein-coding
Summary: This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA metabolic process, DNA recombination, DNA repair, V(D)J recombination, adaptive immune response, chromosome organization, double-strand break repair, double-strand break repair via nonhomologous end joining, immune system process, interstrand cross-link repair, response to ionizing radiation, telomere maintenance; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, damaged DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, single-stranded DNA endodeoxyribonuclease activity; CC: Golgi apparatus, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Primary immunodeficiency - Mus musculus (mouse)
UniProt: Q8K4J0
Entrez ID: 227525
|
Does Knockout of Cpt1c in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cpt1c
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cpt1c (carnitine palmitoyltransferase 1c)
Type: protein-coding
Summary: Enables palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in axon; dendrite; and endoplasmic reticulum. Part of AMPA glutamate receptor complex. Is active in endoplasmic reticulum membrane; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 73. Orthologous to human CPT1C (carnitine palmitoyltransferase 1C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carnitine metabolic process, fatty acid metabolic process, lipid metabolic process, macromolecule depalmitoylation, regulation of postsynaptic membrane neurotransmitter receptor levels; MF: acyltransferase activity, carnitine O-palmitoyltransferase activity, catalytic activity, hydrolase activity, palmitoyl-(protein) hydrolase activity, transferase activity; CC: AMPA glutamate receptor complex, axon, cell projection, dendrite, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, mitochondrion, postsynapse, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse)
UniProt: Q8BGD5
Entrez ID: 78070
|
Does Knockout of Bclaf1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Bclaf1
|
cell proliferation
|
Regulatory T cell
|
Gene: Bclaf1 (BCL2-associated transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cellular response to leukemia inhibitory factor, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription initiation, positive regulation of apoptotic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transcription by RNA polymerase II; MF: DNA binding, protein binding, transcription coregulator activity; CC: cytoplasm, mediator complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q8K019
Entrez ID: 72567
|
Does Knockout of Adra2b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Adra2b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Adra2b (adrenergic receptor, alpha 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, angiogenesis, epidermal growth factor receptor signaling pathway, female pregnancy, platelet activation, positive regulation of MAPK cascade, positive regulation of blood pressure, positive regulation of neuron differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of uterine smooth muscle contraction, regulation of smooth muscle contraction, regulation of vascular associated smooth muscle contraction, regulation of vasoconstriction, signal transduction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha2-adrenergic receptor activity, epinephrine binding, protein binding; CC: cell surface, cytosol, membrane, plasma membrane
Pathways: Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenoceptors, Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (z) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Signal Transduction, Signaling by GPCR, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P30545
Entrez ID: 11552
|
Does Knockout of Mrpl28 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Mrpl28
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Mrpl28 (mitochondrial ribosomal protein L28)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1B9
Entrez ID: 68611
|
Does Knockout of Smok3a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Smok3a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Smok3a (sperm motility kinase 3A)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: C0HKC8
Entrez ID: 545814
|
Does Knockout of Syk in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Syk
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Syk (spleen tyrosine kinase)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of lymphocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver and notochord. Human ortholog(s) of this gene implicated in immunodeficiency 82. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell receptor signaling pathway, G protein-coupled receptor signaling pathway, TORC1 signaling, adaptive immune response, amyloid-beta clearance, angiogenesis, antigen receptor-mediated signaling pathway, apoptotic signaling pathway, autophagosome assembly, beta selection, blood vessel morphogenesis, cell activation, cell surface pattern recognition receptor signaling pathway, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to lectin, cellular response to lipid, cellular response to low-density lipoprotein particle stimulus, cellular response to molecule of fungal origin, cellular response to nutrient levels, collagen-activated tyrosine kinase receptor signaling pathway, defense response to bacterium, enzyme-linked receptor protein signaling pathway, establishment of localization in cell, immune system process, innate immune response, integrin-mediated signaling pathway, interleukin-3-mediated signaling pathway, intracellular signal transduction, leukocyte activation involved in immune response, leukocyte cell-cell adhesion, leukotriene biosynthetic process, lymph vessel development, macrophage activation involved in immune response, negative regulation of TORC1 signaling, negative regulation of autophagy, neutrophil activation involved in immune response, neutrophil chemotaxis, peptidyl-tyrosine phosphorylation, positive regulation of B cell differentiation, positive regulation of MAPK cascade, positive regulation of TORC1 signaling, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, positive regulation of autophagy, positive regulation of bone resorption, positive regulation of calcium-mediated signaling, positive regulation of cell adhesion mediated by integrin, positive regulation of cold-induced thermogenesis, positive regulation of cytokine production, positive regulation of gamma-delta T cell differentiation, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-3 production, positive regulation of interleukin-4 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of mast cell cytokine production, positive regulation of mast cell degranulation, positive regulation of monocyte chemotactic protein-1 production, positive regulation of protein-containing complex assembly, positive regulation of receptor internalization, positive regulation of superoxide anion generation, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, protein import into nucleus, receptor internalization, regulation of ERK1 and ERK2 cascade, regulation of arachidonate secretion, regulation of immune response, regulation of neutrophil degranulation, regulation of phagocytosis, regulation of platelet activation, regulation of platelet aggregation, regulation of superoxide anion generation, regulation of tumor necrosis factor-mediated signaling pathway, serotonin secretion, serotonin secretion by platelet, stimulatory C-type lectin receptor signaling pathway; MF: ATP binding, SH2 domain binding, Toll-like receptor binding, integrin binding, interleukin-15 receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatase binding, phospholipase binding, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold protein binding, signaling receptor binding, transferase activity, ubiquitin protein ligase binding; CC: B cell receptor complex, T cell receptor complex, cytoplasm, cytoplasmic vesicle, cytosol, early phagosome, membrane, nucleus, phagocytic vesicle, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Dectin-2 family, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FCGR activation, FLT3 Signaling, FLT3 signaling through SRC family kinases, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, GPVI-mediated activation cascade, Hemostasis, Herpes simplex virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Integrin signaling, Interleukin-2 family signaling, Interleukin-2 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P48025
Entrez ID: 20963
|
Does Knockout of Zfyve28 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Zfyve28
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfyve28 (zinc finger, FYVE domain containing 28)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor-activated receptor activity; MF: metal ion binding, phosphatidylinositol-3-phosphate binding, zinc ion binding; CC: cytoplasm, cytosol, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q6ZPK7
Entrez ID: 231125
|
Does Knockout of Mobp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Mobp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mobp (myelin-associated oligodendrocytic basic protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: structural constituent of myelin sheath; CC: cytoplasm, cytosol, mitochondrion, myelin sheath, perinuclear region of cytoplasm
Pathways:
UniProt: Q9D2P8
Entrez ID: 17433
|
Does Knockout of Ush2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ush2a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ush2a (usherin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, establishment of localization in cell, establishment of protein localization, hair cell differentiation, inner ear auditory receptor cell differentiation, inner ear receptor cell differentiation, maintenance of animal organ identity, photoreceptor cell maintenance, sensory organ development, sensory perception of light stimulus, sensory perception of sound, system development, tissue development, visual perception; MF: collagen binding, identical protein binding, myosin binding, protein binding; CC: USH2 complex, apical plasma membrane, basement membrane, cell projection, ciliary basal body, cytoplasm, extracellular region, membrane, neuronal cell body, periciliary membrane compartment, photoreceptor connecting cilium, photoreceptor inner segment, plasma membrane, stereocilia ankle link, stereocilia ankle link complex, stereocilium, stereocilium bundle, stereocilium membrane, terminal bouton
Pathways:
UniProt: Q2QI47
Entrez ID: 22283
|
Does Knockout of Usp18 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Usp18
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Usp18 (ubiquitin specific peptidase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response, regulation of protein stability, response to bacterium, response to other organism, response to stilbenoid; MF: ISG15-specific peptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, molecular adaptor activity, peptidase activity, protein binding; CC: cytosol, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deubiquitination, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Post-translational protein modification, Regulation of IFNA/IFNB signaling, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases
UniProt: Q9WTV6
Entrez ID: 24110
|
Does Knockout of Ada in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ada
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ada (adenosine deaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP catabolic process, AMP salvage, GMP salvage, IMP salvage, Peyer's patch development, T cell activation, adenosine catabolic process, adenosine metabolic process, allantoin metabolic process, amide catabolic process, cell adhesion, dAMP catabolic process, dATP catabolic process, deoxyadenosine catabolic process, embryonic digestive tract development, germinal center B cell differentiation, histamine secretion, hypoxanthine biosynthetic process, hypoxanthine salvage, in utero embryonic development, inhibition of non-skeletal tissue mineralization, inosine biosynthetic process, liver development, lung alveolus development, lung development, negative regulation of adenosine receptor signaling pathway, negative regulation of apoptotic process, negative regulation of circadian sleep/wake cycle, non-REM sleep, negative regulation of inflammatory response, negative regulation of leukocyte migration, negative regulation of mature B cell apoptotic process, negative regulation of mucus secretion, negative regulation of penile erection, negative regulation of thymocyte apoptotic process, nucleotide metabolic process, placenta development, positive regulation of B cell proliferation, positive regulation of T cell activation, positive regulation of T cell differentiation, positive regulation of T cell differentiation in thymus, positive regulation of T cell receptor signaling pathway, positive regulation of alpha-beta T cell differentiation, positive regulation of calcium-mediated signaling, positive regulation of germinal center formation, positive regulation of heart rate, positive regulation of smooth muscle contraction, purine nucleotide salvage, purine ribonucleoside monophosphate biosynthetic process, regulation of T cell differentiation, regulation of T cell differentiation in thymus, regulation of cell-cell adhesion mediated by integrin, regulation of circadian sleep/wake cycle, sleep, response to hypoxia, response to purine-containing compound, response to vitamin E, trophectodermal cell differentiation, xanthine biosynthetic process; MF: 2'-deoxyadenosine deaminase activity, adenosine deaminase activity, deaminase activity, hydrolase activity, metal ion binding, purine nucleoside binding, zinc ion binding; CC: anchoring junction, cell surface, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle lumen, cytosol, dendrite cytoplasm, external side of plasma membrane, extracellular space, lysosome, membrane, neuronal cell body, plasma membrane
Pathways: Drug ADME, Metabolism, Metabolism of nucleotides, Nucleotide salvage, Primary immunodeficiency - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Purine salvage, Ribavirin ADME, adenine and adenosine salvage III, adenosine nucleotides degradation II, purine nucleotides degradation II (aerobic), purine ribonucleosides degradation to ribose-1-phosphate
UniProt: P03958
Entrez ID: 11486
|
Does Knockout of Bpgm in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Bpgm
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Bpgm (2,3-bisphosphoglycerate mutase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to stress, defense response to protozoan, erythrocyte development, establishment of blood-brain barrier, glycolytic process, neuroinflammatory response, nucleoside phosphate metabolic process, oxygen transport; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity
Pathways: Glucose metabolism, Glycine, serine and threonine metabolism - Mus musculus (mouse), Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Rapoport-Luebering glycolytic shunt
UniProt: P15327
Entrez ID: 12183
|
Does Knockout of Ubxn10 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Ubxn10
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Ubxn10 (UBX domain protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cell projection organization, cilium assembly; CC: cell projection, cilium, endoplasmic reticulum, intraciliary transport particle B
Pathways:
UniProt: Q8BG34
Entrez ID: 212190
|
Does Knockout of Spag6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Spag6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Spag6 (sperm associated antigen 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, epithelial cilium movement involved in extracellular fluid movement, filopodium assembly, neuron projection extension, sperm axoneme assembly; CC: acrosomal vesicle, axoneme, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, microtubule, microtubule cytoskeleton, motile cilium, sperm principal piece
Pathways:
UniProt: G3UWQ4, Q3V0U9
Entrez ID: 381350
|
Does Knockout of Prkdc in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,540
|
Knockout
|
Prkdc
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell lineage commitment, DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, T cell differentiation in thymus, T cell lineage commitment, T cell receptor V(D)J recombination, V(D)J recombination, activation of innate immune response, brain development, cGAS/STING signaling pathway, cellular response to insulin stimulus, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, ectopic germ cell programmed cell death, heart development, immature B cell differentiation, immune system process, immunoglobulin V(D)J recombination, innate immune response, intrinsic apoptotic signaling pathway in response to DNA damage, lymphocyte differentiation, maturation of 5.8S rRNA, mitotic G1 DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cellular senescence, negative regulation of immunoglobulin production, negative regulation of protein phosphorylation, negative regulation of response to gamma radiation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of apoptotic process, positive regulation of biosynthetic process, positive regulation of developmental growth, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of erythrocyte differentiation, positive regulation of fibroblast proliferation, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of platelet formation, positive regulation of transcription by RNA polymerase II, positive regulation of translation, pro-B cell differentiation, protein destabilization, protein localization to chromatin, regulation of circadian rhythm, regulation of epithelial cell proliferation, regulation of hematopoietic stem cell differentiation, regulation of smooth muscle cell proliferation, replication fork processing, response to activity, response to gamma radiation, response to ionizing radiation, rhythmic process, ribosome biogenesis, small-subunit processome assembly, somitogenesis, spleen development, telomere capping, telomere maintenance, thymus development; MF: ATP binding, DNA-dependent protein kinase activity, RNA polymerase II-specific DNA-binding transcription factor binding, U3 snoRNA binding, double-stranded DNA binding, enzyme binding, histone H2AXS139 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromatin, cytoplasm, cytosol, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, small-subunit processome, transcription regulator complex
Pathways: Cell cycle - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Protein ubiquitination
UniProt: P97313
Entrez ID: 19090
|
Does Knockout of Sulf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Sulf1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sulf1 (sulfatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bone development, cartilage condensation, cartilage development, cell adhesion, chondrocyte development, embryonic skeletal system development, esophagus smooth muscle contraction, glial cell-derived neurotrophic factor receptor signaling pathway, glomerular basement membrane development, glomerular filtration, heparan sulfate proteoglycan metabolic process, innervation, kidney development, limb joint morphogenesis, negative regulation of angiogenesis, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of prostatic bud formation, positive regulation of BMP signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of vascular endothelial growth factor production, regulation of fibroblast growth factor receptor signaling pathway, sulfur compound metabolic process, vascular endothelial growth factor receptor signaling pathway; MF: N-acetylglucosamine-6-sulfatase activity, arylsulfatase activity, calcium ion binding, glycosaminoglycan binding, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: Golgi apparatus, Golgi stack, cell surface, endoplasmic reticulum, extracellular region, extracellular space, membrane raft, plasma membrane
Pathways:
UniProt: Q8K007
Entrez ID: 240725
|
Does Knockout of Hmgcs1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hmgcs1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA metabolic process, cellular response to low-density lipoprotein particle stimulus, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, response to purine-containing compound, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, isomerase activity, organic acid binding, protein homodimerization activity, small molecule binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Butanoate metabolism - Mus musculus (mouse), Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, PPAR signaling pathway - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), ketogenesis, mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: Q8JZK9
Entrez ID: 208715
|
Does Knockout of Rasgrp4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Rasgrp4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rasgrp4 (RAS guanyl releasing protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, antibacterial innate immune response, cell differentiation, immune response, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of natural killer cell mediated immunity, small GTPase-mediated signal transduction; MF: diacylglycerol binding, guanyl-nucleotide exchange factor activity, lipid binding, metal ion binding, zinc ion binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: Q8BTM9
Entrez ID: 233046
|
Does Knockout of Jam3 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Jam3
|
cell proliferation
|
Regulatory T cell
|
Gene: Jam3 (junction adhesion molecule 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, adherens junction assembly, angiogenesis, apical protein localization, cell adhesion, cell differentiation, cell migration, cell-cell adhesion, cell-matrix adhesion, establishment of cell polarity, granulocyte migration, hematopoietic stem cell migration to bone marrow, heterotypic cell-cell adhesion, leukocyte migration involved in inflammatory response, myelination, myeloid progenitor cell differentiation, negative regulation of cell adhesion mediated by integrin, negative regulation of integrin activation, neutrophil homeostasis, positive regulation of membrane permeability, positive regulation of monocyte extravasation, protein localization to cell junction, protein localization to cell surface, regulation of actin cytoskeleton organization by cell-cell adhesion, regulation of neutrophil chemotaxis, spermatid development, spermatogenesis, system development, transmission of nerve impulse; MF: cell-cell adhesion mediator activity, identical protein binding, integrin binding, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: Golgi apparatus, Schmidt-Lanterman incisure, anchoring junction, bicellular tight junction, cell surface, cell-cell contact zone, cell-cell junction, desmosome, extracellular region, extracellular space, filamentous actin, membrane, microvillus, paranodal junction, plasma membrane, protein complex involved in cell adhesion, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Cell surface interactions at the vascular wall, Extracellular matrix organization, Hemostasis, Integrin cell surface interactions, Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q9D8B7
Entrez ID: 83964
|
Does Knockout of Kif3c in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Kif3c
|
cell cycle progression
|
breast epithelium
|
Gene: Kif3c (kinesin family member 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, positive regulation of neuron projection development; MF: ATP binding, ATP hydrolysis activity, kinesin binding, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: axon, cytoplasm, cytoskeleton, cytosol, dendrite, growth cone, kinesin complex, microtubule, microtubule cytoskeleton, microtubule plus-end, neuronal cell body, neuronal ribonucleoprotein granule, synaptic vesicle
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cilium Assembly, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Organelle biogenesis and maintenance, Vesicle-mediated transport
UniProt: O35066
Entrez ID: 16570
|
Does Knockout of Pja1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Pja1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pja1 (praja ring finger ubiquitin ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein catabolic process, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: O55176
Entrez ID: 18744
|
Does Knockout of Vim in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Vim
|
phagocytosis
|
macrophage
|
Gene: Vim (vimentin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Bergmann glial cell differentiation, astrocyte development, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to type II interferon, cytoskeleton organization, intermediate filament organization, intermediate filament-based process, lens fiber cell development, negative regulation of neuron projection development, positive regulation of collagen biosynthetic process, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of glial cell proliferation, regulation of Schwann cell migration, regulation of axonogenesis, regulation of mRNA stability; MF: RNA binding, double-stranded RNA binding, identical protein binding, keratin filament binding, kinase binding, molecular adaptor activity, protein binding, protein domain specific binding, protein phosphatase 2A binding, protein tyrosine kinase binding, scaffold protein binding, structural constituent of cytoskeleton, structural constituent of eye lens; CC: axon, cell body, cell leading edge, cell projection, cytoplasm, cytoskeleton, cytosol, intermediate filament, intermediate filament cytoskeleton, membrane, neuron projection, nuclear matrix, nucleus, perinuclear region of cytoplasm, peroxisome, phagocytic vesicle, plasma membrane, supramolecular fiber, type III intermediate filament
Pathways: Aggrephagy, Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Autophagy, Caspase-mediated cleavage of cytoskeletal proteins, Epstein-Barr virus infection - Mus musculus (mouse), Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), Muscle contraction, Programmed Cell Death, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Striated Muscle Contraction
UniProt: P20152
Entrez ID: 22352
|
Does Knockout of Ugt2b5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Ugt2b5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ugt2b5 (UDP glucuronosyltransferase 2 family, polypeptide B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen metabolic process, lipid metabolic process, steroid metabolic process; MF: UDP-glycosyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, nuclear outer membrane
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), nicotine degradation II, nicotine degradation III
UniProt: Q3UWB9, Q8K169
Entrez ID: 22238
|
Does Knockout of Gbp10 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Gbp10
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gbp10 (guanylate-binding protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, cellular response to type II interferon, defense response to Gram-positive bacterium, defense response to protozoan, immune system process, innate immune response; MF: GTP binding, GTPase activity, hydrolase activity; CC: cytoplasmic vesicle
Pathways:
UniProt: Q000W5
Entrez ID: 626578
|
Does Knockout of AI182371 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
AI182371
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: AI182371 (expressed sequence AI182371)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, complement activation, complement activation, GZMK pathway, complement activation, alternative pathway, complement activation, classical pathway, complement activation, lectin pathway, inflammatory response, innate immune response, leukocyte chemotaxis, negative regulation of macrophage chemotaxis, positive regulation of chemokine production, positive regulation of vascular endothelial growth factor production; MF: chemokine activity, endopeptidase inhibitor activity, molecular_function, receptor ligand activity; CC: cellular_component, extracellular region, extracellular space, membrane attack complex, other organism cell membrane, transmembrane transporter complex
Pathways:
UniProt: A2AS37, Q8BWN9, Q8BWS8, A0A0J9YUP3, A0A2I3BQE1, A0A2I3BRQ1
Entrez ID: 98870
|
Does Knockout of Eif4ebp1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Eif4ebp1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, IRES-dependent translational initiation of linear mRNA, TOR signaling, cellular response to dexamethasone stimulus, cellular response to hypoxia, insulin receptor signaling pathway, negative regulation of protein-containing complex assembly, negative regulation of translation, negative regulation of translational initiation, positive regulation of mitotic cell cycle, regulation of translation, regulation of translational initiation, response to amino acid starvation; MF: eukaryotic initiation factor 4E binding, protein binding, protein phosphatase 2A binding, translation initiation factor binding, translation repressor activity; CC: cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynaptic cytosol, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Acute myeloid leukemia - Mus musculus (mouse), Cap-dependent Translation Initiation, Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Eukaryotic Translation Initiation, HIF-1 signaling pathway - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, Metabolism of proteins, PI3K-Akt signaling pathway - Mus musculus (mouse), Signal Transduction, Translation, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q60876
Entrez ID: 13685
|
Does Knockout of Cdk13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Cdk13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cdk13 (cyclin dependent kinase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, hemopoiesis, mRNA processing, negative regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, cytosol, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Neutrophil degranulation, RNA Polymerase II Transcription, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q69ZA1
Entrez ID: 69562
|
Does Knockout of 4930523C07Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
4930523C07Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 4930523C07Rik (RIKEN cDNA 4930523C07 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CE67, E9Q2T4
Entrez ID: 67647
|
Does Knockout of Usp24 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Usp24
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Usp24 (ubiquitin specific peptidase 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytosol, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: B1AY13
Entrez ID: 329908
|
Does Knockout of Ugt1a6a in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Ugt1a6a
|
cell proliferation
|
Regulatory T cell
|
Gene: Ugt1a6a (UDP glucuronosyltransferase 1 family, polypeptide A6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 4-chlorobiphenyl metabolic process, L-ascorbic acid biosynthetic process, cellular response to glucocorticoid stimulus, glucuronate metabolic process, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, alpha-glucuronidase activity, enzyme binding, glucuronosyltransferase activity, glycosyltransferase activity, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, protein-containing complex
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Aspirin ADME, Bile secretion - Mus musculus (mouse), Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Glucuronidation, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Paracetamol ADME, Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), nicotine degradation II, nicotine degradation III
UniProt: Q64435
Entrez ID: 94284
|
Does Knockout of Sfmbt1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Sfmbt1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Sfmbt1 (Scm-like with four mbt domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromatin organization, negative regulation of DNA-templated transcription, negative regulation of muscle organ development, regulation of DNA-templated transcription, spermatogenesis; MF: chromatin binding, histone binding, protein binding, transcription corepressor activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9JMD1
Entrez ID: 54650
|
Does Knockout of Gpatch1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gpatch1
|
phagocytosis
|
macrophage
|
Gene: Gpatch1 (G patch domain containing 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human GPATCH1 (G-patch domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, mRNA processing; MF: RNA binding, molecular_function, nucleic acid binding; CC: catalytic step 2 spliceosome, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9DBM1
Entrez ID: 67471
|
Does Knockout of Pld1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Pld1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Pld1 (phospholipase D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nutrient, defense response to Gram-positive bacterium, intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process, phospholipid catabolic process, positive regulation of cell migration, positive regulation of translation, regulation of microvillus assembly, regulation of synaptic vesicle cycle, regulation of vesicle-mediated transport, response to peptide hormone; MF: catalytic activity, hydrolase activity, phosphatidylinositol binding, phospholipase D activity, protein binding; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, apical plasma membrane, cholinergic synapse, cytoplasm, cytoplasmic vesicle, endocytic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, lamellipodium, late endosome membrane, membrane, perinuclear region of cytoplasm, plasma membrane, synapse, vesicle
Pathways: Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), choline biosynthesis III, phospholipases
UniProt: Q3UWT7, Q6NVF2, D6RH77, F6QJR6, D3Z2V2, F6WKY8
Entrez ID: 18805
|
Does Knockout of Edem2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Edem2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Edem2 (ER degradation enhancer, mannosidase alpha-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, carbohydrate metabolic process, endoplasmic reticulum mannose trimming, endoplasmic reticulum unfolded protein response, positive regulation of retrograde protein transport, ER to cytosol, response to unfolded protein, ubiquitin-dependent glycoprotein ERAD pathway; MF: calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum quality control compartment, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q8BJT9
Entrez ID: 108687
|
Does Knockout of Eif2ak3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Eif2ak3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3)
Type: protein-coding
Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: ER overload response, ERAD pathway, PERK-mediated unfolded protein response, SREBP signaling pathway, angiogenesis, bone mineralization, calcium-mediated signaling, cellular response to amino acid starvation, cellular response to cold, cellular response to glucose starvation, chondrocyte development, eiF2alpha phosphorylation in response to endoplasmic reticulum stress, endocrine pancreas development, endoplasmic reticulum organization, endoplasmic reticulum unfolded protein response, fat cell differentiation, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lactation, mitochondrial respirasome assembly, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of myelination, negative regulation of translation, negative regulation of translation in response to endoplasmic reticulum stress, negative regulation of translation in response to stress, ossification, pancreas development, positive regulation of ERAD pathway, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of gene expression, positive regulation of glutathione biosynthetic process, positive regulation of protein localization to nucleus, positive regulation of signal transduction, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autophosphorylation, regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, regulation of fatty acid metabolic process, regulation of translation, regulation of translation initiation in response to endoplasmic reticulum stress, regulation of translational initiation, regulation of translational initiation by eIF2 alpha phosphorylation, regulation of translational initiation in response to stress, response to endoplasmic reticulum stress, response to oxidative stress, response to unfolded protein, skeletal system development, translation, translational initiation; MF: ATP binding, Hsp90 protein binding, enzyme binding, eukaryotic initiation factor eIF2 binding, eukaryotic translation initiation factor 2alpha kinase activity, identical protein binding, kinase activity, misfolded protein binding, nucleotide binding, protein binding, protein kinase activity, protein phosphatase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity, translation regulator activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, nucleus, perinuclear region of cytoplasm
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cellular responses to stimuli, Cellular responses to stress, Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), PERK regulates gene expression, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Unfolded Protein Response (UPR)
UniProt: Q9Z2B5
Entrez ID: 13666
|
Does Knockout of Ropn1l in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ropn1l
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ropn1l (ropporin 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium movement, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, mating, sperm capacitation; MF: identical protein binding, protein binding; CC: 9+2 motile cilium, cell projection, cilium, cytoplasm, extracellular region, motile cilium, nucleoplasm, radial spoke, sperm flagellum
Pathways:
UniProt: Q9EQ00
Entrez ID: 252967
|
Does Knockout of Tmprss12 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tmprss12
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmprss12 (transmembrane (C-terminal) protease, serine 12)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Involved in acrosome assembly and positive regulation of sperm capacitation. Acts upstream of or within binding activity of sperm to zona pellucida and protein processing. Located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: acrosome assembly, binding of sperm to zona pellucida, cell differentiation, positive regulation of sperm capacitation, protein processing, proteolysis, single fertilization, spermatogenesis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, cytoplasmic vesicle, membrane, plasma membrane
Pathways:
UniProt: Q3V0Q7
Entrez ID: 75002
|
Does Knockout of 9030624G23Rik in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
9030624G23Rik
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: 9030624G23Rik (RIKEN cDNA 9030624G23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D308
Entrez ID: 66808
|
Does Knockout of D17H6S53E in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
D17H6S53E
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: D17H6S53E (DNA segment, Chr 17, human D6S53E)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9Z1R4
Entrez ID: 114585
|
Does Knockout of Cacna1f in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Cacna1f
|
cell cycle progression
|
breast epithelium
|
Gene: Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit)
Type: protein-coding
Summary: Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; neuron projection morphogenesis; and visual perception. Predicted to be located in membrane; perikaryon; and photoreceptor outer segment. Predicted to be part of voltage-gated calcium channel complex. Is expressed in cerebellum and hippocampus. Used to study congenital stationary night blindness 2A. Human ortholog(s) of this gene implicated in Aland Island eye disease; X-linked cone-rod dystrophy 3; congenital stationary night blindness; and congenital stationary night blindness 2A. Orthologous to human CACNA1F (calcium voltage-gated channel subunit alpha1 F). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axonogenesis, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, dendrite morphogenesis, detection of light stimulus involved in visual perception, gene expression, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, retina development in camera-type eye, transmembrane transport, visual perception; MF: calcium channel activity, high voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, voltage-gated calcium channel activity; CC: membrane, monoatomic ion channel complex, neuronal cell body, perikaryon, photoreceptor outer segment, plasma membrane, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8C8Q4, Q7TNI3, B1AVA5, B1AVA4, B1AVA6, S4R182
Entrez ID: 54652
|
Does Knockout of Nle1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Nle1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nle1 (notchless homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8VEJ4
Entrez ID: 217011
|
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