uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q1.187 | Q1 | Is CCKAR a druggable gene? | There are currently 4 approved drugs which target CCKAR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CCKAR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5575', 'drugName': 'Proglumide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CCKBR (ENSG00000110148), CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2693', 'drugName': 'Sincalide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3461', 'drugName': 'Ceruletide Diethylamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3801', 'drugName': 'Ceruletide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5374', 'drugName': 'Dexloxiglumide', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2827', 'drugName': 'Ce-326597', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCKAR (ENSG00000163394)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.42 | Q1 | Is AFP a druggable gene? | There are currently no approved drugs targeting AFP, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AFP %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_262', 'drugName': 'Yttrium Y 90 Tacatuzumab Tetraxetan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AFP (ENSG00000081051)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.697 | Q1 | Is IL33 a druggable gene? | There are currently no approved drugs targeting IL33, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL33 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2908', 'drugName': 'Itepekimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL33 (ENSG00000137033)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2323', 'drugName': 'Etokimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL33 (ENSG00000137033)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1319', 'drugName': 'Torudokimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL33 (ENSG00000137033)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.110 | Q1 | Is BDKRB2 a druggable gene? | There are currently 2 approved drugs which target BDKRB2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%BDKRB2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3024', 'drugName': 'Icatibant', 'drugIsApproved': True, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_226', 'drugName': 'Icatibant Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_548', 'drugName': 'Labradimil', 'drugIsApproved': False, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6157', 'drugName': 'Fasitibant', 'drugIsApproved': False, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_297', 'drugName': 'Anatibant', 'drugIsApproved': False, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1160', 'drugName': 'Fasitibant Chloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'BDKRB2 (ENSG00000168398)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.39 | Q1 | Is ADRB2 a druggable gene? | There are currently 90 approved drugs which target ADRB2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADRB2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3721', 'drugName': 'Levosalbutamol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1445', 'drugName': 'Terbutaline Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2925', 'drugName': 'Isoetharine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6175', 'drugName': 'Pirbuterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3747', 'drugName': 'Formoterol Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2058', 'drugName': 'Levalbuterol Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1386', 'drugName': 'Clenbuterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5266', 'drugName': 'Metaproterenol Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4859', 'drugName': 'Olodaterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3727', 'drugName': 'Terbutaline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3597', 'drugName': 'Oxprenolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1915', 'drugName': 'Isoetharine Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4540', 'drugName': 'Salmeterol Xinafoate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3365', 'drugName': 'Dilevalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5769', 'drugName': 'Isoproterenol Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6355', 'drugName': 'Dilevalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4428', 'drugName': 'Formoterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2937', 'drugName': 'Propranolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_440', 'drugName': 'Arformoterol Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6308', 'drugName': 'Arformoterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3427', 'drugName': 'Indacaterol Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4124', 'drugName': 'Vilanterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_837', 'drugName': 'Vilanterol Trifenatate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5322', 'drugName': 'Olodaterol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5671', 'drugName': 'Esmolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_457', 'drugName': 'Rimiterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3508', 'drugName': 'Isoetharine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1135', 'drugName': 'Sotalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5847', 'drugName': 'Protokylol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6022', 'drugName': 'Protokylol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5529', 'drugName': 'Bitolterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1057', 'drugName': 'Penbutolol Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3535', 'drugName': 'Bitolterol Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3043', 'drugName': 'Pirbuterol Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1499', 'drugName': 'Ritodrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5346', 'drugName': 'Isoxsuprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRA1A (ENSG00000120907), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1198', 'drugName': 'Levalbuterol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6354', 'drugName': 'Dilevalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1755', 'drugName': 'Carteolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3364', 'drugName': 'Dilevalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_487', 'drugName': 'Reproterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4718', 'drugName': 'Propranolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4719', 'drugName': 'Propranolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5345', 'drugName': 'Isoxsuprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRA1A (ENSG00000120907), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2938', 'drugName': 'Propranolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_760', 'drugName': 'Timolol Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_761', 'drugName': 'Timolol Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4698', 'drugName': 'Timolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4699', 'drugName': 'Timolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1388', 'drugName': 'Dobutamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1389', 'drugName': 'Dobutamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2853', 'drugName': 'Dobutamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_424', 'drugName': 'Nadolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_425', 'drugName': 'Nadolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4457', 'drugName': 'Pindolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4458', 'drugName': 'Pindolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1443', 'drugName': 'Levobunolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3354', 'drugName': 'Carteolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5672', 'drugName': 'Esmolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4941', 'drugName': 'Esmolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4942', 'drugName': 'Esmolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_307', 'drugName': 'Nebivolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_308', 'drugName': 'Nebivolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6025', 'drugName': 'Nebivolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6026', 'drugName': 'Nebivolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4569', 'drugName': 'Sotalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3598', 'drugName': 'Oxprenolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_152', 'drugName': 'Oxprenolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_153', 'drugName': 'Oxprenolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1551', 'drugName': 'Levobunolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1552', 'drugName': 'Levobunolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3765', 'drugName': 'Penbutolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3766', 'drugName': 'Penbutolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1136', 'drugName': 'Sotalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1058', 'drugName': 'Penbutolol Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2262', 'drugName': 'Metipranolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2263', 'drugName': 'Metipranolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4267', 'drugName': 'Metipranolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4268', 'drugName': 'Metipranolol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5909', 'drugName': 'Pronetalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5910', 'drugName': 'Pronetalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2489', 'drugName': 'Isoxsuprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRA1A (ENSG00000120907), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4770', 'drugName': 'Salmeterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4571', 'drugName': 'Sotalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4570', 'drugName': 'Sotalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6118', 'drugName': 'Celiprolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6117', 'drugName': 'Celiprolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2488', 'drugName': 'Isoxsuprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRA1A (ENSG00000120907), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1134', 'drugName': 'Sotalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), KCNH2 (ENSG00000055118), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2740', 'drugName': 'Isoproterenol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2852', 'drugName': 'Dobutamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2882', 'drugName': 'Indacaterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1717', 'drugName': 'Metaproterenol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1444', 'drugName': 'Levobunolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252), ADRB1 (ENSG00000043591)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6208', 'drugName': 'Tulobuterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6278', 'drugName': 'Albuterol Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1200', 'drugName': 'Isoproterenol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2226', 'drugName': 'Fenoterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1434', 'drugName': 'Albuterol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5085', 'drugName': 'Ritodrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.571 | Q1 | Is HBA1 a druggable gene? | There is 1 drug, Voxelotor, that targets HBA1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HBA1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2318', 'drugName': 'Voxelotor', 'drugIsApproved': True, 'newLinkedTargets_string': 'HBA1 (ENSG00000206172), HBA2 (ENSG00000188536), HBB (ENSG00000244734)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5816', 'drugName': 'Efaproxiral', 'drugIsApproved': False, 'newLinkedTargets_string': 'HBA1 (ENSG00000206172), HBA2 (ENSG00000188536), HBB (ENSG00000244734)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1024 | Q1 | Is P2RX3 a druggable gene? | There are currently no approved drugs targeting P2RX3, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%P2RX3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_913', 'drugName': 'Gefapixant', 'drugIsApproved': False, 'newLinkedTargets_string': 'P2RX3 (ENSG00000109991)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_601', 'drugName': 'Camlipixant', 'drugIsApproved': False, 'newLinkedTargets_string': 'P2RX3 (ENSG00000109991)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1299 | Q1 | Is RPS4Y1 a druggable gene? | There is 1 drug, Ataluren, that targets RPS4Y1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPS4Y1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1478 | Q1 | Is TRAV29DV5 a druggable gene? | There are currently no approved drugs targeting TRAV29DV5, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TRAV29DV5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1483', 'drugName': 'Medi-500', 'drugIsApproved': False, 'newLinkedTargets_string': 'TRAV29DV5 (ENSG00000211810), TRAC (ENSG00000277734), TRBV7-9 (ENSG00000278030), TRGV3 (ENSG00000211699)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5971', 'drugName': 'Tol-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'TRAV29DV5 (ENSG00000211810), TRAC (ENSG00000277734), TRBV7-9 (ENSG00000278030), TRGV3 (ENSG00000211699)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6249', 'drugName': 'Maslimomab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TRAV29DV5 (ENSG00000211810), TRAC (ENSG00000277734), TRBV7-9 (ENSG00000278030), TRGV3 (ENSG00000211699)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.486 | Q1 | Is FZD2 a druggable gene? | There are currently no approved drugs targeting FZD2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FZD2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5828', 'drugName': 'Vantictumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FZD2 (ENSG00000180340), FZD7 (ENSG00000155760), FZD1 (ENSG00000157240), FZD5 (ENSG00000163251), FZD8 (ENSG00000177283)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5825', 'drugName': 'Vantictumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FZD2 (ENSG00000180340), FZD7 (ENSG00000155760), FZD1 (ENSG00000157240), FZD5 (ENSG00000163251), FZD8 (ENSG00000177283)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5826', 'drugName': 'Vantictumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FZD2 (ENSG00000180340), FZD7 (ENSG00000155760), FZD1 (ENSG00000157240), FZD5 (ENSG00000163251), FZD8 (ENSG00000177283)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5829', 'drugName': 'Vantictumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FZD2 (ENSG00000180340), FZD7 (ENSG00000155760), FZD1 (ENSG00000157240), FZD5 (ENSG00000163251), FZD8 (ENSG00000177283)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5827', 'drugName': 'Vantictumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FZD2 (ENSG00000180340), FZD7 (ENSG00000155760), FZD1 (ENSG00000157240), FZD5 (ENSG00000163251), FZD8 (ENSG00000177283)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.470 | Q1 | Is FKBP1A a druggable gene? | There are currently 5 approved drugs which target FKBP1A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FKBP1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5128', 'drugName': 'Tacrolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1925', 'drugName': 'Everolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1130', 'drugName': 'Tacrolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2727', 'drugName': 'Pimecrolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5750', 'drugName': 'Temsirolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2510', 'drugName': 'Sirolimus', 'drugIsApproved': True, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5000', 'drugName': 'Zotarolimus', 'drugIsApproved': False, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3662', 'drugName': 'Olocrolimus', 'drugIsApproved': False, 'newLinkedTargets_string': 'FKBP1A (ENSG00000088832)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.895 | Q1 | Is MMP13 a druggable gene? | There are currently 4 approved drugs which target MMP13, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MMP13 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_289', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_287', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2401', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5151', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2397', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2399', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3047', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_286', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5149', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3049', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3045', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_285', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2400', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3046', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_288', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5150', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5152', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2398', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3048', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1950', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_104', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_105', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1947', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_106', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_107', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_108', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1949', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_109', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1944', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4215', 'drugName': 'Apratastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), ADAM17 (ENSG00000151694)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4216', 'drugName': 'Apratastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), ADAM17 (ENSG00000151694)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1948', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1945', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1946', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.952 | Q1 | Is NDUFAF3 a druggable gene? | There are currently 2 approved drugs which target NDUFAF3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFAF3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.25 | Q1 | Is ADH6 a druggable gene? | There is 1 drug, Nitrefazole, that targets ADH6, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADH6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6344', 'drugName': 'Nitrefazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADH1A (ENSG00000187758), ADH4 (ENSG00000198099), ADH1B (ENSG00000196616), ADH1C (ENSG00000248144), ADH7 (ENSG00000196344), ADH5 (ENSG00000197894), ADH6 (ENSG00000172955)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1036 | Q1 | Is PARP2 a druggable gene? | There are currently 7 approved drugs which target PARP2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PARP2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_100', 'drugName': 'Talazoparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2224', 'drugName': 'Talazoparib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2225', 'drugName': 'Talazoparib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_99', 'drugName': 'Talazoparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_279', 'drugName': 'Olaparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP3 (ENSG00000041880), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4162', 'drugName': 'Niraparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4163', 'drugName': 'Niraparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6042', 'drugName': 'Rucaparib Camsylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP3 (ENSG00000041880), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3166', 'drugName': 'Rucaparib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP3 (ENSG00000041880), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4883', 'drugName': 'Niraparib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4882', 'drugName': 'Niraparib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3202', 'drugName': 'Pamiparib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3201', 'drugName': 'Pamiparib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2514', 'drugName': 'Veliparib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP3 (ENSG00000041880), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5032', 'drugName': 'Senaparib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5033', 'drugName': 'Senaparib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP2 (ENSG00000129484), PARP1 (ENSG00000143799)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1419', 'drugName': '2X-121', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNKS2 (ENSG00000107854), TNKS (ENSG00000173273), PARP1 (ENSG00000143799), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1420', 'drugName': '2X-121', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNKS2 (ENSG00000107854), TNKS (ENSG00000173273), PARP1 (ENSG00000143799), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1421', 'drugName': '2X-121', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNKS2 (ENSG00000107854), TNKS (ENSG00000173273), PARP1 (ENSG00000143799), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3523', 'drugName': 'E-7016', 'drugIsApproved': False, 'newLinkedTargets_string': 'PARP1 (ENSG00000143799), PARP3 (ENSG00000041880), PARP2 (ENSG00000129484)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1222 | Q1 | Is RNPEPL1 a druggable gene? | There are currently no approved drugs targeting RNPEPL1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RNPEPL1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), LAP3 (ENSG00000002549), METAP2 (ENSG00000111142), XPNPEP2 (ENSG00000122121), ERAP2 (ENSG00000164308), ERAP1 (ENSG00000164307), LVRN (ENSG00000172901), AOPEP (ENSG00000148120), METAP1D (ENSG00000172878), NPEPL1 (ENSG00000215440), RNPEPL1 (ENSG00000142327), XPNPEP3 (ENSG00000196236)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.69 | Q1 | Is APCS a druggable gene? | There are currently no approved drugs targeting APCS, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%APCS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5164', 'drugName': 'Dezamizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APCS (ENSG00000132703)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1308', 'drugName': 'Miridesap', 'drugIsApproved': False, 'newLinkedTargets_string': 'APCS (ENSG00000132703)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.889 | Q1 | Is MKNK2 a druggable gene? | There are currently no approved drugs targeting MKNK2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MKNK2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1066', 'drugName': 'Tomivosertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'MKNK2 (ENSG00000099875), MKNK1 (ENSG00000079277)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1297 | Q1 | Is RPS3A a druggable gene? | There is 1 drug, Ataluren, that targets RPS3A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPS3A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.368 | Q1 | Is DNMT3A a druggable gene? | There are currently 2 approved drugs which target DNMT3A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DNMT3A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4132', 'drugName': 'Azacitidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DNMT1 (ENSG00000130816), DNMT3A (ENSG00000119772)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4131', 'drugName': 'Azacitidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DNMT1 (ENSG00000130816), DNMT3A (ENSG00000119772)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2159', 'drugName': 'Decitabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DNMT1 (ENSG00000130816), DNMT3A (ENSG00000119772)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2158', 'drugName': 'Decitabine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DNMT1 (ENSG00000130816), DNMT3A (ENSG00000119772)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.508 | Q1 | Is GABRQ a druggable gene? | There are currently 66 approved drugs which target GABRQ, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GABRQ %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1494', 'drugName': 'Thiopental', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2287', 'drugName': 'Clomethiazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5701', 'drugName': 'Triazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4453', 'drugName': 'Chlordiazepoxide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2275', 'drugName': 'Oxazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6282', 'drugName': 'Estazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4750', 'drugName': 'Clorazepic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2327', 'drugName': 'Pentobarbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1496', 'drugName': 'Clonazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3142', 'drugName': 'Lorazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_314', 'drugName': 'Methohexital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 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(ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5041', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4008', 'drugName': 'Midazolam Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2188', 'drugName': 'Midazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 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GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4253', 'drugName': 'Flumazenil', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5294', 'drugName': 'Eszopiclone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5981', 'drugName': 'Clobazam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2197', 'drugName': 'Methoxyflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1369', 'drugName': 'Ganaxolone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), 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(ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3265', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2854', 'drugName': 'Chlordiazepoxide Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4143', 'drugName': 'Methohexital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3295', 'drugName': 'Ethchlorvynol', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_653', 'drugName': 'Flurazepam Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_757', 'drugName': 'Pentobarbital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3020', 'drugName': 'Glutethimide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4122', 'drugName': 'Halazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_215', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4830', 'drugName': 'Prazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_341', 'drugName': 'Metharbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1441', 'drugName': 'Methyprylon', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2585', 'drugName': 'Triclofos Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2623', 'drugName': 'Talbutal', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3021', 'drugName': 'Triclofos', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3421', 'drugName': 'Thiamylal Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1073', 'drugName': 'Primidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3415', 'drugName': 'Butalbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3979', 'drugName': 'Quazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1800', 'drugName': 'Remimazolam Besylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1332', 'drugName': 'Flunitrazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2025', 'drugName': 'Methaqualone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3278', 'drugName': 'Tetrazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4173', 'drugName': 'Methaqualone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2196', 'drugName': 'Methoxyflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_211', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3380', 'drugName': 'Remimazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_214', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5594', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5595', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5597', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5598', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5599', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5600', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3261', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3262', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 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'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_210', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2509', 'drugName': 'Cenobamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2508', 'drugName': 'Cenobamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_164', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_163', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_216', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_212', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2024', 'drugName': 'Brexanolone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5271', 'drugName': 'Clorazepate Dipotassium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5596', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5547', 'drugName': 'Secobarbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4460', 'drugName': 'Alprazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4971', 'drugName': 'Thiopental Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6336', 'drugName': 'Flurazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_143', 'drugName': 'Meprobamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1439', 'drugName': 'Diazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.855 | Q1 | Is MAP3K8 a druggable gene? | There are currently no approved drugs targeting MAP3K8, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MAP3K8 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6134', 'drugName': 'Tilpisertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K8 (ENSG00000107968)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1348 | Q1 | Is SELPLG a druggable gene? | There are currently no approved drugs targeting SELPLG, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SELPLG %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3018', 'drugName': 'Neihulizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELPLG (ENSG00000110876)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.385 | Q1 | Is E2F8 a druggable gene? | There are currently no approved drugs targeting E2F8, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%E2F8 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4614', 'drugName': 'Edifoligide Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'E2F1 (ENSG00000101412), E2F2 (ENSG00000007968), E2F3 (ENSG00000112242), E2F4 (ENSG00000205250), E2F5 (ENSG00000133740), E2F6 (ENSG00000169016), E2F7 (ENSG00000165891), E2F8 (ENSG00000129173)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1850', 'drugName': 'Edifoligide', 'drugIsApproved': False, 'newLinkedTargets_string': 'E2F1 (ENSG00000101412), E2F2 (ENSG00000007968), E2F3 (ENSG00000112242), E2F4 (ENSG00000205250), E2F5 (ENSG00000133740), E2F6 (ENSG00000169016), E2F7 (ENSG00000165891), E2F8 (ENSG00000129173)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.739 | Q1 | Is KCNA6 a druggable gene? | There are currently 5 approved drugs which target KCNA6, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNA6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.722 | Q1 | Is ITGB1 a druggable gene? | There is 1 drug, Natalizumab, that targets ITGB1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ITGB1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5016', 'drugName': 'Natalizumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'ITGA4 (ENSG00000115232), ITGB7 (ENSG00000139626), ITGB1 (ENSG00000150093)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5015', 'drugName': 'Natalizumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'ITGA4 (ENSG00000115232), ITGB7 (ENSG00000139626), ITGB1 (ENSG00000150093)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1021', 'drugName': 'Volociximab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB1 (ENSG00000150093), ITGA5 (ENSG00000161638)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1967', 'drugName': 'Abituzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGAV (ENSG00000138448), ITGB6 (ENSG00000115221), ITGB5 (ENSG00000082781), ITGB3 (ENSG00000259207), ITGB1 (ENSG00000150093), ITGB8 (ENSG00000105855)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2077', 'drugName': 'Firategrast', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB1 (ENSG00000150093), ITGA4 (ENSG00000115232), ITGB7 (ENSG00000139626)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_173', 'drugName': 'Atn-161', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB1 (ENSG00000150093), ITGA5 (ENSG00000161638), ITGB3 (ENSG00000259207), ITGAV (ENSG00000138448)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1965', 'drugName': 'Abituzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGAV (ENSG00000138448), ITGB6 (ENSG00000115221), ITGB5 (ENSG00000082781), ITGB3 (ENSG00000259207), ITGB1 (ENSG00000150093), ITGB8 (ENSG00000105855)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2078', 'drugName': 'Firategrast', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB1 (ENSG00000150093), ITGA4 (ENSG00000115232), ITGB7 (ENSG00000139626)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1966', 'drugName': 'Abituzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGAV (ENSG00000138448), ITGB6 (ENSG00000115221), ITGB5 (ENSG00000082781), ITGB3 (ENSG00000259207), ITGB1 (ENSG00000150093), ITGB8 (ENSG00000105855)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1968', 'drugName': 'Abituzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGAV (ENSG00000138448), ITGB6 (ENSG00000115221), ITGB5 (ENSG00000082781), ITGB3 (ENSG00000259207), ITGB1 (ENSG00000150093), ITGB8 (ENSG00000105855)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1969', 'drugName': 'Abituzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGAV (ENSG00000138448), ITGB6 (ENSG00000115221), ITGB5 (ENSG00000082781), ITGB3 (ENSG00000259207), ITGB1 (ENSG00000150093), ITGB8 (ENSG00000105855)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_174', 'drugName': 'Atn-161', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB1 (ENSG00000150093), ITGA5 (ENSG00000161638), ITGB3 (ENSG00000259207), ITGAV (ENSG00000138448)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.456 | Q1 | Is FDPS a druggable gene? | There are currently 9 approved drugs which target FDPS, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FDPS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4717', 'drugName': 'Risedronate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5882', 'drugName': 'Alendronic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2230', 'drugName': 'Ibandronate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4706', 'drugName': 'Zoledronic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4184', 'drugName': 'Pamidronate Disodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1390', 'drugName': 'Ibandronic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4741', 'drugName': 'Alendronate Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1294', 'drugName': 'Risedronic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4461', 'drugName': 'Pamidronic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2268', 'drugName': 'Minodronic Acid', 'drugIsApproved': False, 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.266 | Q1 | Is CHRNA3 a druggable gene? | There are currently 6 approved drugs which target CHRNA3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CHRNA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5467', 'drugName': 'Trimethaphan Camsylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4467', 'drugName': 'Trimethaphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_120', 'drugName': 'Mecamylamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1272', 'drugName': 'Mecamylamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4468', 'drugName': 'Pentolinium Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4982', 'drugName': 'Pentolinium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6218', 'drugName': 'Larazotide', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1963', 'drugName': 'Larazotide Acetate', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2742', 'drugName': 'Simpinicline', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRNB2 (ENSG00000160716), CHRNA4 (ENSG00000101204)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_23', 'drugName': 'Asm-024', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRNA7 (ENSG00000175344)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_27', 'drugName': 'Asm-024', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRNA7 (ENSG00000175344)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2741', 'drugName': 'Simpinicline', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRNB2 (ENSG00000160716), CHRNA4 (ENSG00000101204)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_24', 'drugName': 'Asm-024', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRNA7 (ENSG00000175344)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_25', 'drugName': 'Asm-024', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRNA7 (ENSG00000175344)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_26', 'drugName': 'Asm-024', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNB4 (ENSG00000117971), CHRNA3 (ENSG00000080644), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRNA7 (ENSG00000175344)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.76 | Q1 | Is APP a druggable gene? | There is 1 drug, Aducanumab, that targets APP, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%APP %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4177', 'drugName': 'Aducanumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3123', 'drugName': 'Tramiprosate', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3737', 'drugName': 'Bapineuzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4034', 'drugName': 'Valiltramiprosate', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3274', 'drugName': 'Solanezumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_439', 'drugName': 'Gantenerumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2736', 'drugName': 'Lecanemab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_158', 'drugName': 'Crenezumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3823', 'drugName': 'Donanemab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3769', 'drugName': 'Ponezumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5607', 'drugName': 'Gsk933776', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3156', 'drugName': 'Vanutide Cridificar', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5272', 'drugName': 'Amilomotide', 'drugIsApproved': False, 'newLinkedTargets_string': 'APP (ENSG00000142192)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.446 | Q1 | Is FAAH a druggable gene? | There is 1 drug, Acetaminophen, that targets FAAH, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FAAH %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_147', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_146', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_148', 'drugName': 'Acetaminophen', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), TRPV1 (ENSG00000196689), FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5455', 'drugName': 'Jnj-42165279', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4984', 'drugName': 'Pf-04457845', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAAH (ENSG00000117480)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.397 | Q1 | Is EGR1 a druggable gene? | There are currently no approved drugs targeting EGR1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EGR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_862', 'drugName': 'Brivoligide', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGR1 (ENSG00000120738)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.178 | Q1 | Is CASP3 a druggable gene? | There are currently no approved drugs targeting CASP3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CASP3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_45', 'drugName': 'Emricasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP4 (ENSG00000196954), CASP9 (ENSG00000132906), CASP3 (ENSG00000164305), CASP5 (ENSG00000137757), CASP6 (ENSG00000138794), CASP7 (ENSG00000165806), CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP2 (ENSG00000106144), CASP10 (ENSG00000003400), CASP14 (ENSG00000105141), CASP12 (ENSG00000204403)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1343 | Q1 | Is SCTR a druggable gene? | There are currently 3 approved drugs which target SCTR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SCTR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4400', 'drugName': 'Secretin', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCTR (ENSG00000080293)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4712', 'drugName': 'Secretin Synthetic Human', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCTR (ENSG00000080293)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_462', 'drugName': 'Secretin Synthetic Porcine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCTR (ENSG00000080293)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1113 | Q1 | Is PPARA a druggable gene? | There are currently 7 approved drugs which target PPARA, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PPARA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_347', 'drugName': 'Fenofibric Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4561', 'drugName': 'Ciprofibrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6015', 'drugName': 'Gemfibrozil', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1497', 'drugName': 'Fenofibrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4196', 'drugName': 'Choline Fenofibrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2331', 'drugName': 'Clofibrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1564', 'drugName': 'Bezafibrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5284', 'drugName': 'Elafibranor', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_176', 'drugName': 'Saroglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2204', 'drugName': 'Pemafibrate', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5138', 'drugName': 'Chiglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5002', 'drugName': 'Tesaglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5283', 'drugName': 'Elafibranor', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1265', 'drugName': 'Imiglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5001', 'drugName': 'Tesaglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5491', 'drugName': 'Aleglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6202', 'drugName': 'Mk-0767', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2055', 'drugName': 'K-877', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1645', 'drugName': 'Lanifibranor', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5490', 'drugName': 'Aleglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_175', 'drugName': 'Saroglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6203', 'drugName': 'Mk-0767', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1266', 'drugName': 'Imiglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6342', 'drugName': 'Muraglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6343', 'drugName': 'Muraglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_627', 'drugName': 'Drf-10945', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1113', 'drugName': 'Indeglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_118', 'drugName': 'Gw590735', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2837', 'drugName': 'Ave8134', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1633', 'drugName': 'Naveglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2834', 'drugName': 'Zyh7', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3379', 'drugName': 'Ly-518674', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6325', 'drugName': 'Cp-778875', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1634', 'drugName': 'Naveglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5445', 'drugName': 'Sodelglitazar', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PPARA (ENSG00000186951), PPARD (ENSG00000112033)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1059 | Q1 | Is PDE7A a druggable gene? | There are currently 4 approved drugs which target PDE7A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PDE7A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_766', 'drugName': 'Flavoxate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4263', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4264', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6107', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1988', 'drugName': 'Flavoxate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1987', 'drugName': 'Flavoxate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_764', 'drugName': 'Flavoxate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6106', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_765', 'drugName': 'Flavoxate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1989', 'drugName': 'Flavoxate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.599 | Q1 | Is HPD a druggable gene? | There is 1 drug, Nitisinone, that targets HPD, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HPD %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4714', 'drugName': 'Nitisinone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HPD (ENSG00000158104)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.62 | Q1 | Is ANGPT2 a druggable gene? | There is 1 drug, Faricimab, that targets ANGPT2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ANGPT2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_864', 'drugName': 'Faricimab', 'drugIsApproved': True, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), VEGFA (ENSG00000112715)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_865', 'drugName': 'Faricimab', 'drugIsApproved': True, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), VEGFA (ENSG00000112715)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1928', 'drugName': 'Trebananib', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), ANGPT1 (ENSG00000154188)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1927', 'drugName': 'Trebananib', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), ANGPT1 (ENSG00000154188)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1274', 'drugName': 'Nesvacumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2715', 'drugName': 'Vanucizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), VEGFA (ENSG00000112715)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1159', 'drugName': 'Zansecimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2714', 'drugName': 'Vanucizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), VEGFA (ENSG00000112715)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3314', 'drugName': 'Cvx-060', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2596', 'drugName': 'Medi-3617', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1732', 'drugName': 'Amg-780', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), ANGPT1 (ENSG00000154188)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1733', 'drugName': 'Amg-780', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), ANGPT1 (ENSG00000154188)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.877 | Q1 | Is MEN1 a druggable gene? | There are currently no approved drugs targeting MEN1, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MEN1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1716', 'drugName': 'Revumenib', 'drugIsApproved': False, 'newLinkedTargets_string': 'MEN1 (ENSG00000133895), KMT2A (ENSG00000118058)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3382', 'drugName': 'Sndx-5613', 'drugIsApproved': False, 'newLinkedTargets_string': 'MEN1 (ENSG00000133895), KMT2A (ENSG00000118058)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1146 | Q1 | Is PRMT5 a druggable gene? | There are currently no approved drugs targeting PRMT5, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRMT5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1649', 'drugName': 'Pemrametostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRMT5 (ENSG00000100462)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1442 | Q1 | Is TNF a druggable gene? | There are currently 5 approved drugs which target TNF, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6275', 'drugName': 'Infliximab', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_393', 'drugName': 'Golimumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5407', 'drugName': 'Certolizumab Pegol', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2071', 'drugName': 'Etanercept', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3802', 'drugName': 'Adalimumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3844', 'drugName': 'Lenercept', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3686', 'drugName': 'Onercept', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1151', 'drugName': 'Nerelimomab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2321', 'drugName': 'Abbv-3373', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810), NR3C1 (ENSG00000113580)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2322', 'drugName': 'Abbv-3373', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810), NR3C1 (ENSG00000113580)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3313', 'drugName': 'Remtolumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810), IL17A (ENSG00000112115)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3954', 'drugName': 'Az9773', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2592', 'drugName': 'Pegsunercept', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1519', 'drugName': 'Placulumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5268', 'drugName': 'Ozoralizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3312', 'drugName': 'Remtolumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810), IL17A (ENSG00000112115)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_51', 'drugName': 'Afelimomab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNF (ENSG00000232810)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.280 | Q1 | Is CLEC4C a druggable gene? | There are currently no approved drugs targeting CLEC4C, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CLEC4C %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4112', 'drugName': 'Litifilimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CLEC4C (ENSG00000198178)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.37 | Q1 | Is ADRA2C a druggable gene? | There are currently 58 approved drugs which target ADRA2C, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADRA2C %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4923', 'drugName': 'Brimonidine Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5012', 'drugName': 'Tizanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4563', 'drugName': 'Levonordefrin', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5436', 'drugName': 'Apraclonidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5908', 'drugName': 'Brimonidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4856', 'drugName': 'Rauwolfia Serpentina', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3385', 'drugName': 'Tizanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6083', 'drugName': 'Dexmedetomidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3892', 'drugName': 'Ephedrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3056', 'drugName': 'Lofexidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3520', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6307', 'drugName': 'Methyldopate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4494', 'drugName': 'Xylometazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_615', 'drugName': 'Clonidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5463', 'drugName': 'Phenoxybenzamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2038', 'drugName': 'Apraclonidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6118', 'drugName': 'Celiprolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6119', 'drugName': 'Celiprolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4968', 'drugName': 'Mirtazapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HTR2C (ENSG00000147246), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4969', 'drugName': 'Mirtazapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HTR2C (ENSG00000147246), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4970', 'drugName': 'Mirtazapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HTR2C (ENSG00000147246), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4092', 'drugName': 'Clonidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1742', 'drugName': 'Labetalol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4318', 'drugName': 'Droxidopa', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3521', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5983', 'drugName': 'Guanfacine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_842', 'drugName': 'Dipivefrin', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2950', 'drugName': 'Hydroxyamphetamine Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_770', 'drugName': 'Moxisylyte', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5214', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2810', 'drugName': 'Guanabenz', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3568', 'drugName': 'Phentolamine Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6296', 'drugName': 'Methyldopa', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4828', 'drugName': 'Naphazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_327', 'drugName': 'Naphazoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4912', 'drugName': 'Guanfacine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3839', 'drugName': 'Lofexidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_545', 'drugName': 'Tetrahydrozoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_543', 'drugName': 'Oxymetazoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_103', 'drugName': 'Oxymetazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1879', 'drugName': 'Phenoxybenzamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1330', 'drugName': 'Alseroxylon', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3551', 'drugName': 'Ergotamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1D (ENSG00000179546), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3552', 'drugName': 'Ergotamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1D (ENSG00000179546), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3131', 'drugName': 'Ergotamine Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), HTR1D (ENSG00000179546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3132', 'drugName': 'Ergotamine Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), HTR1D (ENSG00000179546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2843', 'drugName': 'Tolazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2844', 'drugName': 'Tolazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2845', 'drugName': 'Tolazoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2553', 'drugName': 'Tolazoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2554', 'drugName': 'Tolazoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1992', 'drugName': 'Norepinephrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1843', 'drugName': 'Norepinephrine Bitartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_901', 'drugName': 'Epinephrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5211', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5404', 'drugName': 'Labetalol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5213', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5325', 'drugName': 'Ephedrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4567', 'drugName': 'Mephentermine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4285', 'drugName': 'Mephentermine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1884', 'drugName': 'Epinephrine Bitartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3519', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1692', 'drugName': 'Dipivefrin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3522', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6117', 'drugName': 'Celiprolol', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRB1 (ENSG00000043591), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), ADRB2 (ENSG00000169252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2555', 'drugName': 'Tolazoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639), HRH2 (ENSG00000113749), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1779', 'drugName': 'Dexmedetomidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2547', 'drugName': 'Phentolamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1295', 'drugName': 'Tetrahydrozoline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5212', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4865', 'drugName': 'Ephedrine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1918', 'drugName': 'Hydroxyamphetamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), ADRB3 (ENSG00000188778)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5960', 'drugName': 'Methyldopate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1472', 'drugName': 'Guanabenz Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1787', 'drugName': 'Esmirtazapine Maleate', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3944', 'drugName': 'Aviptadil', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4192', 'drugName': 'Idazoxan', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1786', 'drugName': 'Esmirtazapine Maleate', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1784', 'drugName': 'Esmirtazapine Maleate', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1785', 'drugName': 'Esmirtazapine Maleate', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3807', 'drugName': 'Esmirtazapine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3804', 'drugName': 'Esmirtazapine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3805', 'drugName': 'Esmirtazapine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3806', 'drugName': 'Esmirtazapine', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286), HRH1 (ENSG00000196639), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3752', 'drugName': 'Orm-12741', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA2C (ENSG00000184160)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_209', 'drugName': 'Fipamezole', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6056', 'drugName': 'Fadolmidine Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5966', 'drugName': 'Fadolmidine', 'drugIsApproved': False, 'newLinkedTargets_string': 'ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA2B (ENSG00000274286)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.666 | Q1 | Is IL10RA a druggable gene? | There are currently no approved drugs targeting IL10RA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL10RA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4152', 'drugName': 'Pegilodecakin', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL10RB (ENSG00000243646), IL10RA (ENSG00000110324)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1385 | Q1 | Is SNCA a druggable gene? | There are currently no approved drugs targeting SNCA, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SNCA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1283', 'drugName': 'Prasinezumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'SNCA (ENSG00000145335)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5903', 'drugName': 'Cinpanemab', 'drugIsApproved': False, 'newLinkedTargets_string': 'SNCA (ENSG00000145335)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1344 | Q1 | Is SDC1 a druggable gene? | There are currently no approved drugs targeting SDC1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SDC1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_294', 'drugName': 'Indatuximab Ravtansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SDC1 (ENSG00000115884)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.983 | Q1 | Is NISCH a druggable gene? | There is 1 drug, Moxonidine, that targets NISCH, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NISCH %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2347', 'drugName': 'Moxonidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'NISCH (ENSG00000010322)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3253', 'drugName': 'Rilmenidine', 'drugIsApproved': False, 'newLinkedTargets_string': 'NISCH (ENSG00000010322)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.743 | Q1 | Is KCNC1 a druggable gene? | There are currently 5 approved drugs which target KCNC1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNC1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.193 | Q1 | Is CCR1 a druggable gene? | There are currently no approved drugs targeting CCR1, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CCR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_194', 'drugName': 'Bms-817399', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCR1 (ENSG00000163823)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_200', 'drugName': 'Ccx354', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCR1 (ENSG00000163823)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2706', 'drugName': 'Azd4818', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCR1 (ENSG00000163823)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.924 | Q1 | Is MYH7B a druggable gene? | There is 1 drug, Mavacamten, that targets MYH7B, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MYH7B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1036', 'drugName': 'Mavacamten', 'drugIsApproved': True, 'newLinkedTargets_string': 'MYH7 (ENSG00000092054), MYH6 (ENSG00000197616), MYH7B (ENSG00000078814), MYL3 (ENSG00000160808), MYL2 (ENSG00000111245), MYL7 (ENSG00000106631), MYL4 (ENSG00000198336)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1448', 'drugName': 'Omecamtiv Mecarbil', 'drugIsApproved': False, 'newLinkedTargets_string': 'MYH7 (ENSG00000092054), MYH6 (ENSG00000197616), MYH7B (ENSG00000078814), MYL3 (ENSG00000160808), MYL2 (ENSG00000111245), MYL7 (ENSG00000106631), MYL4 (ENSG00000198336)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2405', 'drugName': 'Danicamtiv', 'drugIsApproved': False, 'newLinkedTargets_string': 'MYH7 (ENSG00000092054), MYH6 (ENSG00000197616), MYH7B (ENSG00000078814), MYL3 (ENSG00000160808), MYL2 (ENSG00000111245), MYL7 (ENSG00000106631), MYL4 (ENSG00000198336)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.458 | Q1 | Is FFAR2 a druggable gene? | There are currently no approved drugs targeting FFAR2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FFAR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5482', 'drugName': 'Glpg-0974', 'drugIsApproved': False, 'newLinkedTargets_string': 'FFAR2 (ENSG00000126262)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.680 | Q1 | Is IL18R1 a druggable gene? | There are currently no approved drugs targeting IL18R1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL18R1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2219', 'drugName': 'Iboctadekin', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL18RAP (ENSG00000115607), IL18R1 (ENSG00000115604)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.765 | Q1 | Is KCNJ3 a druggable gene? | There is 1 drug, Vernakalant, that targets KCNJ3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNJ3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_716', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_718', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_715', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_717', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_719', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1590', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1586', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1587', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1589', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1588', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1386 | Q1 | Is SOAT1 a druggable gene? | There is 1 drug, Benfluorex, that targets SOAT1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SOAT1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5285', 'drugName': 'Benfluorex', 'drugIsApproved': True, 'newLinkedTargets_string': 'SOAT1 (ENSG00000057252)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6272', 'drugName': 'Pactimibe', 'drugIsApproved': False, 'newLinkedTargets_string': 'SOAT2 (ENSG00000167780), SOAT1 (ENSG00000057252)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3381', 'drugName': 'Nevanimibe', 'drugIsApproved': False, 'newLinkedTargets_string': 'SOAT1 (ENSG00000057252)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6271', 'drugName': 'Pactimibe', 'drugIsApproved': False, 'newLinkedTargets_string': 'SOAT2 (ENSG00000167780), SOAT1 (ENSG00000057252)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.733 | Q1 | Is KCNA1 a druggable gene? | There are currently 5 approved drugs which target KCNA1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNA1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.414 | Q1 | Is EPHA7 a druggable gene? | There is 1 drug, Vandetanib, that targets EPHA7, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHA7 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1936', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1934', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1932', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1931', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1937', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1935', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1933', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.830 | Q1 | Is LTA a druggable gene? | There are currently no approved drugs targeting LTA, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LTA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_937', 'drugName': 'Pateclizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'LTA (ENSG00000226979)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5474', 'drugName': 'Baminercept', 'drugIsApproved': False, 'newLinkedTargets_string': 'LTA (ENSG00000226979), LTB (ENSG00000227507), TNFSF14 (ENSG00000125735)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5475', 'drugName': 'Baminercept', 'drugIsApproved': False, 'newLinkedTargets_string': 'LTA (ENSG00000226979), LTB (ENSG00000227507), TNFSF14 (ENSG00000125735)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.620 | Q1 | Is HTR2A a druggable gene? | There are currently 65 approved drugs which target HTR2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4892', 'drugName': 'Carphenazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5097', 'drugName': 'Pimavanserin Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5143', 'drugName': 'Cyclobenzaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1324', 'drugName': 'Cyclobenzaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3644', 'drugName': 'Paliperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4975', 'drugName': 'Trazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2624', 'drugName': 'Thiothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_788', 'drugName': 'Molindone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_789', 'drugName': 'Molindone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5142', 'drugName': 'Cyclobenzaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4488', 'drugName': 'Mesoridazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3634', 'drugName': 'Mesoridazine Besylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3042', 'drugName': 'Molindone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_460', 'drugName': 'Haloperidol Decanoate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3643', 'drugName': 'Paliperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1229', 'drugName': 'Droperidol', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4103', 'drugName': 'Asenapine Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_461', 'drugName': 'Haloperidol Decanoate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1060', 'drugName': 'Asenapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1061', 'drugName': 'Asenapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4312', 'drugName': 'Iloperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5388', 'drugName': 'Paliperidone Palmitate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5389', 'drugName': 'Paliperidone Palmitate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3924', 'drugName': 'Lurasidone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3925', 'drugName': 'Lurasidone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5708', 'drugName': 'Lurasidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4487', 'drugName': 'Mesoridazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4286', 'drugName': 'Ziprasidone Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2207', 'drugName': 'Thiothixene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2208', 'drugName': 'Thiothixene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3633', 'drugName': 'Mesoridazine Besylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6350', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3041', 'drugName': 'Molindone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3158', 'drugName': 'Carphenazine Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3784', 'drugName': 'Clozapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4082', 'drugName': 'Nefazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2989', 'drugName': 'Chlorpromazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5161', 'drugName': 'Haloperidol Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4589', 'drugName': 'Chlorprothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4081', 'drugName': 'Nefazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1228', 'drugName': 'Droperidol', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5048', 'drugName': 'Nefazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5045', 'drugName': 'Nefazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4083', 'drugName': 'Nefazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4976', 'drugName': 'Trazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4977', 'drugName': 'Trazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1291', 'drugName': 'Trazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1292', 'drugName': 'Trazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1293', 'drugName': 'Trazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3865', 'drugName': 'Risperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3866', 'drugName': 'Risperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4441', 'drugName': 'Quetiapine Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4442', 'drugName': 'Quetiapine Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4443', 'drugName': 'Quetiapine Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6234', 'drugName': 'Quetiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6235', 'drugName': 'Quetiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6236', 'drugName': 'Quetiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3393', 'drugName': 'Ziprasidone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3394', 'drugName': 'Ziprasidone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1683', 'drugName': 'Ziprasidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1684', 'drugName': 'Ziprasidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1685', 'drugName': 'Ziprasidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2619', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2620', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2621', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5046', 'drugName': 'Nefazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4287', 'drugName': 'Ziprasidone Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4288', 'drugName': 'Ziprasidone Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4679', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4680', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4681', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6348', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6349', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4586', 'drugName': 'Chlorprothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3134', 'drugName': 'Lumateperone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), SLC6A4 (ENSG00000108576), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3135', 'drugName': 'Lumateperone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), SLC6A4 (ENSG00000108576), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3136', 'drugName': 'Lumateperone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), SLC6A4 (ENSG00000108576), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5257', 'drugName': 'Haloperidol', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3159', 'drugName': 'Carphenazine Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3160', 'drugName': 'Carphenazine Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4891', 'drugName': 'Carphenazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4084', 'drugName': 'Nefazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4893', 'drugName': 'Carphenazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4588', 'drugName': 'Chlorprothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2990', 'drugName': 'Chlorpromazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4040', 'drugName': 'Promazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4039', 'drugName': 'Promazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5047', 'drugName': 'Nefazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4587', 'drugName': 'Chlorprothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5256', 'drugName': 'Haloperidol', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3867', 'drugName': 'Risperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4313', 'drugName': 'Iloperidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2625', 'drugName': 'Thiothixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3392', 'drugName': 'Ziprasidone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5709', 'drugName': 'Lurasidone', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1323', 'drugName': 'Cyclobenzaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5162', 'drugName': 'Haloperidol Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD4 (ENSG00000069696)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4104', 'drugName': 'Asenapine Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_501', 'drugName': 'Pimavanserin', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3785', 'drugName': 'Clozapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.116 | Q1 | Is BLK a druggable gene? | There is 1 drug, Dasatinib, that targets BLK, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%BLK %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4602', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4601', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4599', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4598', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4600', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4603', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), KIT (ENSG00000157404), ABL1 (ENSG00000097007), BCR (ENSG00000186716), EPHA2 (ENSG00000142627)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1177', 'drugName': 'Ilorasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AURKB (ENSG00000178999), AURKC (ENSG00000105146), AURKA (ENSG00000087586), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6126', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6130', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6129', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6125', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6128', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1175', 'drugName': 'Ilorasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AURKB (ENSG00000178999), AURKC (ENSG00000105146), AURKA (ENSG00000087586), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2125', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1176', 'drugName': 'Ilorasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AURKB (ENSG00000178999), AURKC (ENSG00000105146), AURKA (ENSG00000087586), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2123', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2126', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1174', 'drugName': 'Ilorasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AURKB (ENSG00000178999), AURKC (ENSG00000105146), AURKA (ENSG00000087586), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6131', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2122', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2121', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6127', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2124', 'drugName': 'Enmd-981693', 'drugIsApproved': False, 'newLinkedTargets_string': 'KDR (ENSG00000128052), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), AURKA (ENSG00000087586), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4107', 'drugName': 'Xl-228', 'drugIsApproved': False, 'newLinkedTargets_string': 'ABL1 (ENSG00000097007), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), IGF1R (ENSG00000140443)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4108', 'drugName': 'Xl-228', 'drugIsApproved': False, 'newLinkedTargets_string': 'ABL1 (ENSG00000097007), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), IGF1R (ENSG00000140443)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4109', 'drugName': 'Xl-228', 'drugIsApproved': False, 'newLinkedTargets_string': 'ABL1 (ENSG00000097007), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), IGF1R (ENSG00000140443)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.419 | Q1 | Is EPHB4 a druggable gene? | There is 1 drug, Vandetanib, that targets EPHB4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHB4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1936', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1931', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1933', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1935', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1934', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1937', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1932', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4649', 'drugName': 'Tesevatinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), EPHB4 (ENSG00000196411)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4650', 'drugName': 'Tesevatinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), EPHB4 (ENSG00000196411)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4651', 'drugName': 'Tesevatinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), EPHB4 (ENSG00000196411)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4149', 'drugName': 'Ji-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'EPHB4 (ENSG00000196411), PDGFRB (ENSG00000113721), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6129', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6130', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6131', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4147', 'drugName': 'Ji-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'EPHB4 (ENSG00000196411), PDGFRB (ENSG00000113721), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4148', 'drugName': 'Ji-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'EPHB4 (ENSG00000196411), PDGFRB (ENSG00000113721), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6126', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6127', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6128', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6125', 'drugName': 'Tg100-801', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FGFR1 (ENSG00000077782), KDR (ENSG00000128052), FGFR2 (ENSG00000066468), EPHB4 (ENSG00000196411), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG00000111816), FGR (ENSG00000000938), SRMS (ENSG00000125508), FLT1 (ENSG00000102755)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1464 | Q1 | Is TNNI3 a druggable gene? | There are currently no approved drugs targeting TNNI3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNNI3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2198', 'drugName': 'Levosimendan', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), TNNC1 (ENSG00000114854), TNNI3 (ENSG00000129991), TNNT2 (ENSG00000118194)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2199', 'drugName': 'Levosimendan', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), TNNC1 (ENSG00000114854), TNNI3 (ENSG00000129991), TNNT2 (ENSG00000118194)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.975 | Q1 | Is NDUFV1 a druggable gene? | There are currently 2 approved drugs which target NDUFV1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFV1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.608 | Q1 | Is HSD3B2 a druggable gene? | There is 1 drug, Trilostane, that targets HSD3B2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HSD3B2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2278', 'drugName': 'Trilostane', 'drugIsApproved': True, 'newLinkedTargets_string': 'HSD3B2 (ENSG00000203859)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1537 | Q1 | Is XPO1 a druggable gene? | There is 1 drug, Selinexor, that targets XPO1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%XPO1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_58', 'drugName': 'Selinexor', 'drugIsApproved': True, 'newLinkedTargets_string': 'XPO1 (ENSG00000082898)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.91 | Q1 | Is ATP4B a druggable gene? | There are currently 14 approved drugs which target ATP4B, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ATP4B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5144', 'drugName': 'Rabeprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4835', 'drugName': 'Pantoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2162', 'drugName': 'Esomeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3760', 'drugName': 'Esomeprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_908', 'drugName': 'Dexlansoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2645', 'drugName': 'Esomeprazole Strontium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5640', 'drugName': 'Vonoprazan Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5499', 'drugName': 'Vonoprazan', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1903', 'drugName': 'Pantoprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4604', 'drugName': 'Omeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4440', 'drugName': 'Esomeprazole Magnesium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3572', 'drugName': 'Rabeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3369', 'drugName': 'Omeprazole Magnesium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2720', 'drugName': 'Lansoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3592', 'drugName': 'Abeprazan', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2643', 'drugName': 'Ilaprazole', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1354', 'drugName': 'Tegoprazan', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.853 | Q1 | Is MAP3K13 a druggable gene? | There are currently no approved drugs targeting MAP3K13, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MAP3K13 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6091', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6088', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6089', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6092', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6090', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1172 | Q1 | Is PSMC3 a druggable gene? | There are currently 4 approved drugs which target PSMC3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PSMC3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_559', 'drugName': 'Bortezomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4407', 'drugName': 'Ixazomib Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2422', 'drugName': 'Carfilzomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3334', 'drugName': 'Ixazomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_969', 'drugName': 'Oprozomib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1469 | Q1 | Is TOP2A a druggable gene? | There are currently 15 approved drugs which target TOP2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TOP2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2612', 'drugName': 'Teniposide', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4763', 'drugName': 'Etoposide', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4016', 'drugName': 'Dexrazoxane', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_881', 'drugName': 'Daunorubicin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2949', 'drugName': 'Etoposide Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1471', 'drugName': 'Daunorubicin Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2577', 'drugName': 'Mitoxantrone', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1919', 'drugName': 'Daunorubicin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3938', 'drugName': 'Amsacrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_459', 'drugName': 'Idarubicin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4715', 'drugName': 'Mitoxantrone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4222', 'drugName': 'Doxorubicin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6176', 'drugName': 'Valrubicin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_484', 'drugName': 'Doxorubicin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5440', 'drugName': 'Idarubicin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6186', 'drugName': 'Becatecarin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP1 (ENSG00000198900), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4788', 'drugName': 'Pazufloxacin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6187', 'drugName': 'Becatecarin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP1 (ENSG00000198900), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3978', 'drugName': 'Amrubicin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3383', 'drugName': 'Amrubicin Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4789', 'drugName': 'Pazufloxacin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3973', 'drugName': 'Vosaroxin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4550', 'drugName': 'Aldoxorubicin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2112', 'drugName': 'Gancotamab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2383', 'drugName': 'Berubicin Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_332', 'drugName': 'Berubicin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2111', 'drugName': 'Gancotamab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TOP2A (ENSG00000131747), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4528', 'drugName': 'C-1311', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4529', 'drugName': 'C-1311', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5331', 'drugName': 'C-1311', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5332', 'drugName': 'C-1311', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), TOP2A (ENSG00000131747), TOP2B (ENSG00000077097)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.758 | Q1 | Is KCNH4 a druggable gene? | There are currently 5 approved drugs which target KCNH4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNH4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.501 | Q1 | Is GABRB3 a druggable gene? | There are currently 67 approved drugs which target GABRB3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GABRB3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2287', 'drugName': 'Clomethiazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4750', 'drugName': 'Clorazepic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3050', 'drugName': 'Butabarbital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3142', 'drugName': 'Lorazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_143', 'drugName': 'Meprobamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4008', 'drugName': 'Midazolam Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1439', 'drugName': 'Diazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5981', 'drugName': 'Clobazam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3380', 'drugName': 'Remimazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5271', 'drugName': 'Clorazepate Dipotassium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3262', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2854', 'drugName': 'Chlordiazepoxide Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5701', 'drugName': 'Triazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_757', 'drugName': 'Pentobarbital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1108', 'drugName': 'Temazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5114', 'drugName': 'Etomidate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1494', 'drugName': 'Thiopental', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2623', 'drugName': 'Talbutal', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2188', 'drugName': 'Midazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3115', 'drugName': 'Propofol', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6282', 'drugName': 'Estazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2275', 'drugName': 'Oxazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2196', 'drugName': 'Methoxyflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2024', 'drugName': 'Brexanolone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5594', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1369', 'drugName': 'Ganaxolone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_422', 'drugName': 'Butabarbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_210', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5547', 'drugName': 'Secobarbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6371', 'drugName': 'Secobarbital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_314', 'drugName': 'Methohexital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2920', 'drugName': 'Sevoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK18 (ENSG00000186795), KCNK3 (ENSG00000171303), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4143', 'drugName': 'Methohexital Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3295', 'drugName': 'Ethchlorvynol', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_653', 'drugName': 'Flurazepam Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5038', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3020', 'drugName': 'Glutethimide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4122', 'drugName': 'Halazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4971', 'drugName': 'Thiopental Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4830', 'drugName': 'Prazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_341', 'drugName': 'Metharbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1441', 'drugName': 'Methyprylon', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2585', 'drugName': 'Triclofos Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_212', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3021', 'drugName': 'Triclofos', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3421', 'drugName': 'Thiamylal Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5165', 'drugName': 'Thiamylal', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3415', 'drugName': 'Butalbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3979', 'drugName': 'Quazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1800', 'drugName': 'Remimazolam Besylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1332', 'drugName': 'Flunitrazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3278', 'drugName': 'Tetrazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4173', 'drugName': 'Methaqualone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5294', 'drugName': 'Eszopiclone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_211', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), 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(ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5595', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5596', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5597', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5598', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5599', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5600', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3261', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_164', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 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(ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5042', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2025', 'drugName': 'Methaqualone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4253', 'drugName': 'Flumazenil', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6336', 'drugName': 'Flurazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6147', 'drugName': 'Clotiazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1496', 'drugName': 'Clonazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4460', 'drugName': 'Alprazolam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4453', 'drugName': 'Chlordiazepoxide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2327', 'drugName': 'Pentobarbital', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6180', 'drugName': 'Zopiclone', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRA3 (ENSG00000011677), GABRB1 (ENSG00000163288), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.12 | Q1 | Is ACHE a druggable gene? | There are currently 31 approved drugs which target ACHE, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ACHE %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1632', 'drugName': 'Galantamine Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_516', 'drugName': 'Pyridostigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_795', 'drugName': 'Donepezil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4037', 'drugName': 'Donepezil', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3143', 'drugName': 'Galantamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4774', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2899', 'drugName': 'Physostigmine Salicylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_150', 'drugName': 'Ambenonium Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_253', 'drugName': 'Ambenonium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1803', 'drugName': 'Isoflurophate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2522', 'drugName': 'Demecarium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2260', 'drugName': 'Echothiophate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2129', 'drugName': 'Echothiophate Iodide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4772', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3564', 'drugName': 'Physostigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5676', 'drugName': 'Edrophonium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1766', 'drugName': 'Neostigmine Methylsulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4773', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5554', 'drugName': 'Pyridostigmine Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2037', 'drugName': 'Tacrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'BCHE (ENSG00000114200), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_486', 'drugName': 'Rivastigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'BCHE (ENSG00000114200), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6243', 'drugName': 'Tacrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'BCHE (ENSG00000114200), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3732', 'drugName': 'Propanidid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085), BCHE (ENSG00000114200)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3733', 'drugName': 'Propanidid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085), BCHE (ENSG00000114200)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5326', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5327', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5329', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5330', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4771', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4775', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1705', 'drugName': 'Rivastigmine Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'BCHE (ENSG00000114200), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5141', 'drugName': 'Edrophonium Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5352', 'drugName': 'Pralidoxime', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4265', 'drugName': 'Pralidoxime Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4592', 'drugName': 'Hexafluorenium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2851', 'drugName': 'Distigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5328', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4088', 'drugName': 'Demecarium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4011', 'drugName': 'Hexafluorenium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6228', 'drugName': 'Neostigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3004', 'drugName': 'Acotiamide Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5855', 'drugName': 'Acotiamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1148', 'drugName': 'Itopride', 'drugIsApproved': False, 'newLinkedTargets_string': 'ACHE (ENSG00000087085), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1149', 'drugName': 'Itopride', 'drugIsApproved': False, 'newLinkedTargets_string': 'ACHE (ENSG00000087085), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2261', 'drugName': 'Huperzine A', 'drugIsApproved': False, 'newLinkedTargets_string': 'ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.398 | Q1 | Is ELANE a druggable gene? | There is 1 drug, .Alpha.1-Proteinase Inhibitor Human, that targets ELANE, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ELANE %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2772', 'drugName': '.Alpha.1-Proteinase Inhibitor Human', 'drugIsApproved': True, 'newLinkedTargets_string': 'ELANE (ENSG00000197561)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3534', 'drugName': 'Sivelestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ELANE (ENSG00000197561)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_584', 'drugName': 'Depelestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ELANE (ENSG00000197561)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2393', 'drugName': 'Alvelestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ELANE (ENSG00000197561)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.286 | Q1 | Is COL11A2 a druggable gene? | There are currently 2 approved drugs which target COL11A2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL11A2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1275', 'drugName': 'Collagenase Clostridium Histolyticum', 'drugIsApproved': True, 'newLinkedTargets_string': 'COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1072 | Q1 | Is PGA5 a druggable gene? | There is 1 drug, Sucralfate, that targets PGA5, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PGA5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4142', 'drugName': 'Sucralfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PGA5 (ENSG00000256713)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5872', 'drugName': 'Sucralfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PGA5 (ENSG00000256713)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.695 | Q1 | Is IL2RG a druggable gene? | There are currently 4 approved drugs which target IL2RG, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL2RG %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2628', 'drugName': 'Basiliximab', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5681', 'drugName': 'Daclizumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5264', 'drugName': 'Aldesleukin', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5634', 'drugName': 'Denileukin Diftitox', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5633', 'drugName': 'Denileukin Diftitox', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4415', 'drugName': 'Simlukafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAP (ENSG00000078098), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3968', 'drugName': 'Pegenzileukin', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4414', 'drugName': 'Simlukafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAP (ENSG00000078098), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1651', 'drugName': 'Recombinant Human Interleukin-15', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), IL15RA (ENSG00000134470)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1261 | Q1 | Is RPL37A a druggable gene? | There is 1 drug, Ataluren, that targets RPL37A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPL37A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1439 | Q1 | Is TLR9 a druggable gene? | There are currently 2 approved drugs which target TLR9, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TLR9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3879', 'drugName': 'Hydroxychloroquine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732), TLR7 (ENSG00000196664)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3878', 'drugName': 'Hydroxychloroquine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732), TLR7 (ENSG00000196664)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_962', 'drugName': 'Hydroxychloroquine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TLR7 (ENSG00000196664), TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_963', 'drugName': 'Hydroxychloroquine', 'drugIsApproved': True, 'newLinkedTargets_string': 'TLR7 (ENSG00000196664), TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2906', 'drugName': '1018 Iss', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_116', 'drugName': 'Agatolimod', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2420', 'drugName': 'Cobitolimod', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6361', 'drugName': 'Tilsotolimod Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2557', 'drugName': 'Agatolimod Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2813', 'drugName': 'Emd-1201081', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5583', 'drugName': 'Bazlitoran', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR8 (ENSG00000101916), TLR9 (ENSG00000239732), TLR7 (ENSG00000196664)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5067', 'drugName': 'Lefitolimod', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2685', 'drugName': 'Tilsotolimod', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR9 (ENSG00000239732)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5581', 'drugName': 'Bazlitoran', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR8 (ENSG00000101916), TLR9 (ENSG00000239732), TLR7 (ENSG00000196664)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5582', 'drugName': 'Bazlitoran', 'drugIsApproved': False, 'newLinkedTargets_string': 'TLR8 (ENSG00000101916), TLR9 (ENSG00000239732), TLR7 (ENSG00000196664)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.694 | Q1 | Is IL2RB a druggable gene? | There are currently 4 approved drugs which target IL2RB, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL2RB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5633', 'drugName': 'Denileukin Diftitox', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2628', 'drugName': 'Basiliximab', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5681', 'drugName': 'Daclizumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5264', 'drugName': 'Aldesleukin', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5634', 'drugName': 'Denileukin Diftitox', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL2RA (ENSG00000134460), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4414', 'drugName': 'Simlukafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAP (ENSG00000078098), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4415', 'drugName': 'Simlukafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'FAP (ENSG00000078098), IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3968', 'drugName': 'Pegenzileukin', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RG (ENSG00000147168), IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1651', 'drugName': 'Recombinant Human Interleukin-15', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), IL15RA (ENSG00000134470)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4204', 'drugName': 'Humik-Beta-1', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5210', 'drugName': 'Mik-Beta-1', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RB (ENSG00000100385)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.856 | Q1 | Is MAP3K9 a druggable gene? | There are currently no approved drugs targeting MAP3K9, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MAP3K9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6091', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6088', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6089', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6092', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6090', 'drugName': 'Cep-1347', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAP3K13 (ENSG00000073803), MAP3K12 (ENSG00000139625), MAP3K10 (ENSG00000130758), MAP3K9 (ENSG00000006432), MAP3K11 (ENSG00000173327)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.161 | Q1 | Is CACNG2 a druggable gene? | There are currently 9 approved drugs which target CACNG2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CACNG2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_142', 'drugName': 'Gabapentin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4565', 'drugName': 'Bepridil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6291', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6292', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_311', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4910', 'drugName': 'Bepridil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2991', 'drugName': 'Pregabalin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1320', 'drugName': 'Phloroglucinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_310', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1799', 'drugName': 'Suloctidil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4133', 'drugName': 'Gabapentin Enacarbil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2281', 'drugName': 'Imagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2254', 'drugName': 'Atagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.900 | Q1 | Is MMP8 a druggable gene? | There are currently 4 approved drugs which target MMP8, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MMP8 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2398', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3046', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5150', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_289', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2399', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2401', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3045', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_288', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5151', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_286', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3047', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5149', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_287', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3048', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2397', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5152', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2400', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3049', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_285', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1950', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_106', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_107', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1949', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_108', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_109', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1944', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_105', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1945', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1946', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_104', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1947', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1948', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1219 | Q1 | Is RHD a druggable gene? | There are currently no approved drugs targeting RHD, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RHD %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3177', 'drugName': 'Roledumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'RHD (ENSG00000187010)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6033', 'drugName': 'Rozrolimupab', 'drugIsApproved': False, 'newLinkedTargets_string': 'RHD (ENSG00000187010)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4899', 'drugName': 'Morolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'RHD (ENSG00000187010)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5411', 'drugName': 'Atorolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'RHD (ENSG00000187010)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.259 | Q1 | Is CHRM1 a druggable gene? | There are currently 55 approved drugs which target CHRM1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CHRM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2995', 'drugName': 'Glycopyrronium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6050', 'drugName': 'Trihexyphenidyl Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3773', 'drugName': 'Cevimeline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4919', 'drugName': 'Procyclidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6214', 'drugName': 'Biperiden Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1476', 'drugName': 'Diphenidol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4667', 'drugName': 'Diphenidol', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3507', 'drugName': 'Ethopropazine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3800', 'drugName': 'Cycrimine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4978', 'drugName': 'Cycrimine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5327', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2580', 'drugName': 'Dicyclomine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2581', 'drugName': 'Dicyclomine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5330', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2996', 'drugName': 'Glycopyrronium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1138', 'drugName': 'Glycopyrrolate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1139', 'drugName': 'Glycopyrrolate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3828', 'drugName': 'Pilocarpine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3829', 'drugName': 'Pilocarpine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5678', 'drugName': 'Pilocarpine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5679', 'drugName': 'Pilocarpine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2497', 'drugName': 'Cevimeline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2299', 'drugName': 'Dicyclomine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2300', 'drugName': 'Dicyclomine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2031', 'drugName': 'Methscopolamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2032', 'drugName': 'Methscopolamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2696', 'drugName': 'Methscopolamine Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5328', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5885', 'drugName': 'Tridihexethyl', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5748', 'drugName': 'Tridihexethyl Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5749', 'drugName': 'Tridihexethyl Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3595', 'drugName': 'Mepenzolate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3596', 'drugName': 'Mepenzolate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1922', 'drugName': 'Mepenzolate Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1923', 'drugName': 'Mepenzolate Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4773', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2039', 'drugName': 'Benztropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5329', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4391', 'drugName': 'Isopropamide Iodide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6145', 'drugName': 'Anisotropine Methylbromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6146', 'drugName': 'Anisotropine Methylbromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6238', 'drugName': 'Anisotropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6239', 'drugName': 'Anisotropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_72', 'drugName': 'Clidinium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_73', 'drugName': 'Clidinium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_521', 'drugName': 'Oxyphencyclimine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_522', 'drugName': 'Oxyphencyclimine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1720', 'drugName': 'Oxyphenonium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1721', 'drugName': 'Oxyphenonium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2134', 'drugName': 'Diphemanil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2135', 'drugName': 'Diphemanil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3245', 'drugName': 'Hexocyclium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4583', 'drugName': 'Clidinium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4584', 'drugName': 'Clidinium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1166', 'drugName': 'Methixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1167', 'drugName': 'Methixene', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_348', 'drugName': 'Methixene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1163', 'drugName': 'Oxyphenonium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1164', 'drugName': 'Oxyphenonium Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1327', 'drugName': 'Diphemanil Methylsulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1328', 'drugName': 'Diphemanil Methylsulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2265', 'drugName': 'Hexocyclium Methylsulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2266', 'drugName': 'Hexocyclium Methylsulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2409', 'drugName': 'Oxyphencyclimine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2410', 'drugName': 'Oxyphencyclimine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4771', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3774', 'drugName': 'Cevimeline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5326', 'drugName': 'Minaprine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MAOA (ENSG00000189221), DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5673', 'drugName': 'Procyclidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4390', 'drugName': 'Isopropamide Iodide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2724', 'drugName': 'Propantheline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2725', 'drugName': 'Propantheline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2726', 'drugName': 'Propantheline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4309', 'drugName': 'Propantheline Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4310', 'drugName': 'Propantheline Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4311', 'drugName': 'Propantheline Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2047', 'drugName': 'Atropine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2048', 'drugName': 'Atropine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2049', 'drugName': 'Atropine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019), CHRM2 (ENSG00000181072)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3969', 'drugName': 'Atropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM2 (ENSG00000181072), CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3970', 'drugName': 'Atropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM2 (ENSG00000181072), CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4774', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3462', 'drugName': 'Isopropamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3463', 'drugName': 'Isopropamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1550', 'drugName': 'Biperiden Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6291', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4775', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4772', 'drugName': 'Minaprine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD1 (ENSG00000184845), CHRM1 (ENSG00000168539), ACHE (ENSG00000087085), MAOA (ENSG00000189221), HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3244', 'drugName': 'Hexocyclium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2496', 'drugName': 'Cevimeline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5173', 'drugName': 'Ethopropazine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3039', 'drugName': 'Scopolamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6217', 'drugName': 'Trihexyphenidyl', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_349', 'drugName': 'Methixene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2695', 'drugName': 'Methscopolamine Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_321', 'drugName': 'Benztropine Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3971', 'drugName': 'Atropine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM2 (ENSG00000181072), CHRM1 (ENSG00000168539), CHRM3 (ENSG00000133019)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1469', 'drugName': 'Biperiden', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5884', 'drugName': 'Tridihexethyl', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5044', 'drugName': 'Pirenzepine', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.337 | Q1 | Is CXCL12 a druggable gene? | There are currently no approved drugs targeting CXCL12, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CXCL12 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3593', 'drugName': 'Olaptesed Pegol', 'drugIsApproved': False, 'newLinkedTargets_string': 'CXCL12 (ENSG00000107562)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1443 | Q1 | Is TNFRSF10A a druggable gene? | There are currently no approved drugs targeting TNFRSF10A, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNFRSF10A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5538', 'drugName': 'Mapatumumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF10A (ENSG00000104689)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_638', 'drugName': 'Dulanermin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF10A (ENSG00000104689), TNFRSF10B (ENSG00000120889)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_639', 'drugName': 'Dulanermin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF10A (ENSG00000104689), TNFRSF10B (ENSG00000120889)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1045 | Q1 | Is PDE2A a druggable gene? | There are currently 2 approved drugs which target PDE2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PDE2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6107', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6106', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4264', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4263', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.518 | Q1 | Is GHRHR a druggable gene? | There are currently 3 approved drugs which target GHRHR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GHRHR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2825', 'drugName': 'Tesamorelin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHRHR (ENSG00000106128)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5465', 'drugName': 'Sermorelin Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHRHR (ENSG00000106128)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4100', 'drugName': 'Tesamorelin Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHRHR (ENSG00000106128)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1021 | Q1 | Is OPRM1 a druggable gene? | There are currently 82 approved drugs which target OPRM1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%OPRM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1750', 'drugName': 'Methadone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3858', 'drugName': 'Diacetylmorphine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4427', 'drugName': 'Hydromorphone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1463', 'drugName': 'Meperidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6241', 'drugName': 'Methadone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4900', 'drugName': 'Oliceridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4049', 'drugName': 'Oxycodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6302', 'drugName': 'Fentanyl', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_733', 'drugName': 'Fentanyl Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3319', 'drugName': 'Loperamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5566', 'drugName': 'Levallorphan Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_614', 'drugName': 'Difenoxin', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3034', 'drugName': 'Hydromorphone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3599', 'drugName': 'Oxymorphone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3533', 'drugName': 'Sufentanil', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2139', 'drugName': 'Levomethadyl Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5530', 'drugName': 'Tramadol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_494', 'drugName': 'Codeine Polistirex', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3916', 'drugName': 'Fentanyl Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_248', 'drugName': 'Diphenoxylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4682', 'drugName': 'Alvimopan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4812', 'drugName': 'Naloxegol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_264', 'drugName': 'Naloxegol Oxalate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6151', 'drugName': 'Naldemedine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1003', 'drugName': 'Naldemedine Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2471', 'drugName': 'Meptazinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3834', 'drugName': 'Propoxyphene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4532', 'drugName': 'Samidorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2341', 'drugName': 'Dihydrocodeine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3051', 'drugName': 'Naltrexone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6052', 'drugName': 'Loperamide Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4533', 'drugName': 'Samidorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3761', 'drugName': 'Difenoxin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4198', 'drugName': 'Dihydrocodeine Bitartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3984', 'drugName': 'Sufentanil Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2891', 'drugName': 'Samidorphan L-Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2019', 'drugName': 'Alfentanil', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4300', 'drugName': 'Levorphanol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5454', 'drugName': 'Levorphanol Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3387', 'drugName': 'Levomethadyl Acetate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_577', 'drugName': 'Remifentanil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3501', 'drugName': 'Buprenorphine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1391', 'drugName': 'Remifentanil', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2413', 'drugName': 'Methylnaltrexone Bromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3268', 'drugName': 'Tramadol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2904', 'drugName': 'Dextromoramide', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_749', 'drugName': 'Butorphanol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_750', 'drugName': 'Butorphanol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2028', 'drugName': 'Buprenorphine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2029', 'drugName': 'Buprenorphine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3500', 'drugName': 'Buprenorphine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6372', 'drugName': 'Tapentadol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A2 (ENSG00000103546), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6373', 'drugName': 'Tapentadol Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A2 (ENSG00000103546), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4012', 'drugName': 'Tapentadol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4013', 'drugName': 'Tapentadol', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1672', 'drugName': 'Butorphanol Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1673', 'drugName': 'Butorphanol Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1554', 'drugName': 'Anileridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2629', 'drugName': 'Levallorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2630', 'drugName': 'Levallorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4594', 'drugName': 'Anileridine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4595', 'drugName': 'Anileridine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4938', 'drugName': 'Anileridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4939', 'drugName': 'Anileridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5565', 'drugName': 'Levallorphan Tartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2889', 'drugName': 'Samidorphan L-Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1510', 'drugName': 'Dezocine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1511', 'drugName': 'Dezocine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4164', 'drugName': 'Diphenoxylate Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3008', 'drugName': 'Benzhydrocodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3650', 'drugName': 'Morphine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_529', 'drugName': 'Benzhydrocodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4044', 'drugName': 'Nalmefene', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4534', 'drugName': 'Samidorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_245', 'drugName': 'Morphine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4513', 'drugName': 'Hydrocodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1326', 'drugName': 'Nalbuphine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2476', 'drugName': 'Hydrocodone Bitartrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1990', 'drugName': 'Codeine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4963', 'drugName': 'Codeine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4591', 'drugName': 'Oxymorphone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3666', 'drugName': 'Codeine Sulfate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3927', 'drugName': 'Naloxone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5202', 'drugName': 'Naloxone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1991', 'drugName': 'Nalbuphine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_705', 'drugName': 'Nalmefene Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2890', 'drugName': 'Samidorphan L-Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRM1 (ENSG00000112038), OPRD1 (ENSG00000116329)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3607', 'drugName': 'Naltrexone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2492', 'drugName': 'Hydrocodone Polistirex', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRK1 (ENSG00000082556), OPRD1 (ENSG00000116329), OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1780', 'drugName': 'Methylnaltrexone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1331', 'drugName': 'Propoxyphene', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6255', 'drugName': 'Eluxadoline', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1553', 'drugName': 'Anileridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038), OPRK1 (ENSG00000082556)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_754', 'drugName': 'Oxycodone Terephthalate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_303', 'drugName': 'Propoxyphene Napsylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_793', 'drugName': 'Alfentanil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6046', 'drugName': 'Oxycodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_497', 'drugName': 'Meperidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5734', 'drugName': 'Oxycodegol', 'drugIsApproved': False, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3338', 'drugName': 'Bevenopran', 'drugIsApproved': False, 'newLinkedTargets_string': 'OPRM1 (ENSG00000112038)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.773 | Q1 | Is KCNMA1 a druggable gene? | There are currently no approved drugs targeting KCNMA1, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNMA1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2864', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2869', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2865', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2867', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2868', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2866', 'drugName': 'Flindokalner', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNQ4 (ENSG00000117013), KCNQ5 (ENSG00000185760)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3483', 'drugName': 'Bms-223131', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5782', 'drugName': 'Andolast', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNMA1 (ENSG00000156113)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1349 | Q1 | Is SEM1 a druggable gene? | There are currently 4 approved drugs which target SEM1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SEM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_559', 'drugName': 'Bortezomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4407', 'drugName': 'Ixazomib Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2422', 'drugName': 'Carfilzomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3334', 'drugName': 'Ixazomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_969', 'drugName': 'Oprozomib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.766 | Q1 | Is KCNJ5 a druggable gene? | There is 1 drug, Vernakalant, that targets KCNJ5, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNJ5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_716', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_718', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_715', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_717', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_719', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1590', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1586', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1587', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1589', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1588', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1127 | Q1 | Is PRKAB2 a druggable gene? | There are currently no approved drugs targeting PRKAB2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRKAB2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5888', 'drugName': 'Acadesine', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKAA2 (ENSG00000162409), PRKAB2 (ENSG00000131791), PRKAG1 (ENSG00000181929), PRKAG2 (ENSG00000106617), PRKAB1 (ENSG00000111725), PRKAA1 (ENSG00000132356), PRKAG3 (ENSG00000115592)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.524 | Q1 | Is GLRA1 a druggable gene? | There are currently 6 approved drugs which target GLRA1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GLRA1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5597', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5600', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3261', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 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(ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5038', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5039', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5040', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5041', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 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(ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_213', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_214', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_215', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_216', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3267', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5599', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5595', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2197', 'drugName': 'Methoxyflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2196', 'drugName': 'Methoxyflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_211', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2922', 'drugName': 'Sevoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK18 (ENSG00000186795), KCNK3 (ENSG00000171303), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3263', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5598', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5596', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5594', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.23 | Q1 | Is ADH4 a druggable gene? | There is 1 drug, Nitrefazole, that targets ADH4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADH4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6344', 'drugName': 'Nitrefazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADH1A (ENSG00000187758), ADH4 (ENSG00000198099), ADH1B (ENSG00000196616), ADH1C (ENSG00000248144), ADH7 (ENSG00000196344), ADH5 (ENSG00000197894), ADH6 (ENSG00000172955)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.358 | Q1 | Is DGAT1 a druggable gene? | There are currently no approved drugs targeting DGAT1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DGAT1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3433', 'drugName': 'Pradigastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'DGAT1 (ENSG00000185000)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1304 | Q1 | Is RPS6KA3 a druggable gene? | There are currently no approved drugs targeting RPS6KA3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPS6KA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3347', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3348', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3349', 'drugName': 'Tas0612', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPS6KB2 (ENSG00000175634), RPS6KB1 (ENSG00000108443), AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208), RPS6KA3 (ENSG00000177189), RPS6KA2 (ENSG00000071242), RPS6KA6 (ENSG00000072133), RPS6KA1 (ENSG00000117676)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.342 | Q1 | Is CYP11A1 a druggable gene? | There are currently 3 approved drugs which target CYP11A1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CYP11A1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3930', 'drugName': 'Levoketoconazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11B1 (ENSG00000160882), CYP11B2 (ENSG00000179142), CYP17A1 (ENSG00000148795), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3932', 'drugName': 'Levoketoconazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11B1 (ENSG00000160882), CYP11B2 (ENSG00000179142), CYP17A1 (ENSG00000148795), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2692', 'drugName': 'Aminoglutethimide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP19A1 (ENSG00000137869), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5755', 'drugName': 'Mitotane', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11A1 (ENSG00000140459), CYP11B1 (ENSG00000160882)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5754', 'drugName': 'Mitotane', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11A1 (ENSG00000140459), CYP11B1 (ENSG00000160882)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3931', 'drugName': 'Levoketoconazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11B1 (ENSG00000160882), CYP11B2 (ENSG00000179142), CYP17A1 (ENSG00000148795), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3929', 'drugName': 'Levoketoconazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11B1 (ENSG00000160882), CYP11B2 (ENSG00000179142), CYP17A1 (ENSG00000148795), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2691', 'drugName': 'Aminoglutethimide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP19A1 (ENSG00000137869), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.433 | Q1 | Is EZH2 a druggable gene? | There are currently 2 approved drugs which target EZH2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EZH2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4960', 'drugName': 'Tazemetostat Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'EZH2 (ENSG00000106462)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1211', 'drugName': 'Tazemetostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'EZH2 (ENSG00000106462)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_823', 'drugName': 'Gsk2816126', 'drugIsApproved': False, 'newLinkedTargets_string': 'EZH2 (ENSG00000106462)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.475 | Q1 | Is FN1 a druggable gene? | There is 1 drug, Ocriplasmin, that targets FN1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FN1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3654', 'drugName': 'L19Il2', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4643', 'drugName': 'L19Sip 131I', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3095', 'drugName': 'L19Tnfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3027', 'drugName': 'Mu-Bc-1', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_263', 'drugName': 'As-1409', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1516', 'drugName': 'Radretumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FN1 (ENSG00000115414)', 'maxClinicalTrialPhase': -1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.219 | Q1 | Is CD5 a druggable gene? | There are currently no approved drugs targeting CD5, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CD5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4551', 'drugName': 'Telimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'CD5 (ENSG00000110448)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4169', 'drugName': 'Zolimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'CD5 (ENSG00000110448)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.916 | Q1 | Is MTNR1B a druggable gene? | There are currently 4 approved drugs which target MTNR1B, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MTNR1B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5938', 'drugName': 'Ramelteon', 'drugIsApproved': True, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5737', 'drugName': 'Melatonin', 'drugIsApproved': True, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4046', 'drugName': 'Agomelatine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6185', 'drugName': 'Tasimelteon', 'drugIsApproved': True, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4045', 'drugName': 'Agomelatine', 'drugIsApproved': True, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3623', 'drugName': 'Piromelatine', 'drugIsApproved': False, 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
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