uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.586 | Q11 | Are there any AC026188.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC026188.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC026188.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1795 | Q11 | Are there any HSD3B7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the HSD3B7 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4889606
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.59e-07; HEIDI: 4.8322e-03
• rs13708
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.87e-06; HEIDI: 1.6432e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HSD3B7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501472', 'Gene': 'HSD3B7', 'topRSID': 'rs4889606', 'p_SMR_multi': 9.58512e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004832233}, {'UUID': 'NDD_SMR_genes_all_update_text_1342788', 'Gene': 'HSD3B7', 'topRSID': 'rs13708', 'p_SMR_multi': 2.873879e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.001643226}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.771 | Q11 | Are there any RNF214 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene RNF214 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RNF214' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.371 | Q11 | Are there any STX4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the STX4 gene has 6 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs58726213
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.61e-08; HEIDI: 2.7530e-06
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.01e-07; HEIDI: 5.6110e-09
• rs4889609
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.22e-07; HEIDI: 1.1615e-01
• rs3751855
• Cortex: Adjusted SMR multi-SNP P-value: 1.46e-06; HEIDI: 5.2390e-03
• rs1046276
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.10e-06; HEIDI: 9.1486e-03
• rs4468641
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.57e-06; HEIDI: 8.4704e-03
• rs732173
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.89e-06; HEIDI: 6.6468e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'STX4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563810', 'Gene': 'STX4', 'topRSID': 'rs58726213', 'p_SMR_multi': 2.609254e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.752989e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1435344', 'Gene': 'STX4', 'topRSID': 'rs58726213', 'p_SMR_multi': 2.007649e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.610971e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_974678', 'Gene': 'STX4', 'topRSID': 'rs4889609', 'p_SMR_multi': 4.215464e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1161469}, {'UUID': 'NDD_SMR_genes_all_update_text_1140849', 'Gene': 'STX4', 'topRSID': 'rs3751855', 'p_SMR_multi': 1.462118e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.005239034}, {'UUID': 'NDD_SMR_genes_all_update_text_1328406', 'Gene': 'STX4', 'topRSID': 'rs1046276', 'p_SMR_multi': 2.104966e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.009148648}, {'UUID': 'NDD_SMR_genes_all_update_text_974676', 'Gene': 'STX4', 'topRSID': 'rs4468641', 'p_SMR_multi': 2.565939e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008470433}, {'UUID': 'NDD_SMR_genes_all_update_text_1370180', 'Gene': 'STX4', 'topRSID': 'rs732173', 'p_SMR_multi': 2.892341e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.06646784}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.809 | Q11 | Are there any TRIM32 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene TRIM32 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM32' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.31 | Q11 | Are there any RETNLB SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RETNLB that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RETNLB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1960 | Q11 | Are there any CEACAM16 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CEACAM16 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62120574
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.18e-11; HEIDI: 2.0975e-10
• rs7248283
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.79e-10; HEIDI: 1.3793e-15
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CEACAM16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637413', 'Gene': 'CEACAM16', 'topRSID': 'rs62120574', 'p_SMR_multi': 8.179298e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.097485e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_122450', 'Gene': 'CEACAM16', 'topRSID': 'rs7248283', 'p_SMR_multi': 2.793047e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.379269e-15}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1742 | Q11 | Are there any LRRC25 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene LRRC25 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC25' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1577 | Q11 | Are there any METTL2A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene METTL2A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'METTL2A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.794 | Q11 | Are there any SIX2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain and Whole Blood samples tested there are no SNPs within the gene SIX2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SIX2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1249 | Q11 | Are there any SPI1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SPI1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11570034
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.74e-07; HEIDI: 4.3796e-01
• rs12801188
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.27e-06; HEIDI: 5.0728e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498213', 'Gene': 'SPI1', 'topRSID': 'rs11570034', 'p_SMR_multi': 3.736983e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.437956}, {'UUID': 'NDD_SMR_genes_all_update_text_608486', 'Gene': 'SPI1', 'topRSID': 'rs12801188', 'p_SMR_multi': 2.26569e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05072849}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.501 | Q11 | Are there any BCL11B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BCL11B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'BCL11B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1551 | Q11 | Are there any RPS6KB1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene RPS6KB1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RPS6KB1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1568 | Q11 | Are there any SCAND3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SCAND3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs146918648
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.67e-07; HEIDI: 2.6750e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SCAND3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619657', 'Gene': 'SCAND3', 'topRSID': 'rs146918648', 'p_SMR_multi': 4.667572e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2675036}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.991 | Q11 | Are there any CTD-3193O13.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Frontal Cortex, Cortex, Caudate Basal Ganglia, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CTD-3193O13.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-3193O13.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1574 | Q11 | Are there any LINC00665 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene LINC00665 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LINC00665' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.45 | Q11 | Are there any DGKQ SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the DGKQ gene has 22 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs4690229
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 5.21e-11; HEIDI: 2.6292e-06
• rs4690196
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.97e-10; HEIDI: 6.8090e-05
• rs6814642
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.42e-09; HEIDI: 1.3550e-12
• rs4690163
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.56e-09; HEIDI: 7.6581e-08
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.80e-07; HEIDI: 9.5719e-09
• rs2290402
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.04e-09; HEIDI: 1.3491e-06
• rs1377586
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.12e-09; HEIDI: 7.9527e-04
• rs3733349
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.55e-09; HEIDI: 9.2580e-03
• rs3733345
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.62e-08; HEIDI: 2.2082e-02
• rs11724804
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.79e-08; HEIDI: 3.3943e-01
• rs6599390
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.86e-08; HEIDI: 7.0551e-14
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'DGKQ' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1323351', 'Gene': 'DGKQ', 'topRSID': 'rs4690229', 'p_SMR_multi': 5.205442e-11, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 2.62916e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1675610', 'Gene': 'DGKQ', 'topRSID': 'rs4690196', 'p_SMR_multi': 1.972716e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.808963e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1236185', 'Gene': 'DGKQ', 'topRSID': 'rs6814642', 'p_SMR_multi': 1.423406e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 1.355011e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1430184', 'Gene': 'DGKQ', 'topRSID': 'rs4690163', 'p_SMR_multi': 2.561035e-09, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 7.658113e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_996294', 'Gene': 'DGKQ', 'topRSID': 'rs2290402', 'p_SMR_multi': 3.044298e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.349111e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1555640', 'Gene': 'DGKQ', 'topRSID': 'rs1377586', 'p_SMR_multi': 4.119889e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007952652}, {'UUID': 'NDD_SMR_genes_all_update_text_996297', 'Gene': 'DGKQ', 'topRSID': 'rs3733349', 'p_SMR_multi': 6.549745e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009258028}, {'UUID': 'NDD_SMR_genes_all_update_text_19050', 'Gene': 'DGKQ', 'topRSID': 'rs3733345', 'p_SMR_multi': 1.624405e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.02208212}, {'UUID': 'NDD_SMR_genes_all_update_text_429854', 'Gene': 'DGKQ', 'topRSID': 'rs11724804', 'p_SMR_multi': 1.790406e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3394267}, {'UUID': 'NDD_SMR_genes_all_update_text_996292', 'Gene': 'DGKQ', 'topRSID': 'rs6599390', 'p_SMR_multi': 1.863121e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.055133e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_996304', 'Gene': 'DGKQ', 'topRSID': 'rs1377586', 'p_SMR_multi': 4.270117e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001644874}, {'UUID': 'NDD_SMR_genes_all_update_text_429860', 'Gene': 'DGKQ', 'topRSID': 'rs6829197', 'p_SMR_multi': 4.37673e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.005826544}, {'UUID': 'NDD_SMR_genes_all_update_text_996299', 'Gene': 'DGKQ', 'topRSID': 'rs3733346', 'p_SMR_multi': 8.196619e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01001869}, {'UUID': 'NDD_SMR_genes_all_update_text_996295', 'Gene': 'DGKQ', 'topRSID': 'rs4690326', 'p_SMR_multi': 9.952926e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02987631}, {'UUID': 'NDD_SMR_genes_all_update_text_996309', 'Gene': 'DGKQ', 'topRSID': 'rs10794537', 'p_SMR_multi': 2.630247e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.585244e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_996302', 'Gene': 'DGKQ', 'topRSID': 'rs13101828', 'p_SMR_multi': 2.737953e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002942897}, {'UUID': 'NDD_SMR_genes_all_update_text_1635862', 'Gene': 'DGKQ', 'topRSID': 'rs28671147', 'p_SMR_multi': 3.29121e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.969276e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_996301', 'Gene': 'DGKQ', 'topRSID': 'rs13101828', 'p_SMR_multi': 4.199207e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00231421}, {'UUID': 'NDD_SMR_genes_all_update_text_429852', 'Gene': 'DGKQ', 'topRSID': 'rs748483', 'p_SMR_multi': 5.404569e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.044836e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_429849', 'Gene': 'DGKQ', 'topRSID': 'rs28671147', 'p_SMR_multi': 5.723438e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.91238e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_996300', 'Gene': 'DGKQ', 'topRSID': 'rs1377586', 'p_SMR_multi': 7.775161e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01096544}, {'UUID': 'NDD_SMR_genes_all_update_text_429855', 'Gene': 'DGKQ', 'topRSID': 'rs4690163', 'p_SMR_multi': 8.797929e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 9.571883e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1140276', 'Gene': 'DGKQ', 'topRSID': 'rs17781378', 'p_SMR_multi': 8.966522e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.169598e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_429856', 'Gene': 'DGKQ', 'topRSID': 'rs4690163', 'p_SMR_multi': 9.386846e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.455453e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_429853', 'Gene': 'DGKQ', 'topRSID': 'rs6837528', 'p_SMR_multi': 1.14246e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.313849e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_429850', 'Gene': 'DGKQ', 'topRSID': 'rs3736087', 'p_SMR_multi': 1.485443e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.712141e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_429858', 'Gene': 'DGKQ', 'topRSID': 'rs3806755', 'p_SMR_multi': 2.71625e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.055732e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_996307', 'Gene': 'DGKQ', 'topRSID': 'rs11248061', 'p_SMR_multi': 2.931919e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.985962e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1608 | Q11 | Are there any RP11-798G7.6 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-798G7.6 gene has 4 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs113564729
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.94e-11; HEIDI: 2.1837e-09
• rs1819040
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.58e-09; HEIDI: -9.9990e+03
• rs2532233
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.73e-09; HEIDI: 6.0425e-05
• rs11656151
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.28e-07; HEIDI: 2.2306e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-798G7.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564779', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs113564729', 'p_SMR_multi': 1.944697e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.183737e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1242264', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs1819040', 'p_SMR_multi': 3.583956e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640216', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs2532233', 'p_SMR_multi': 3.730133e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 6.042464e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1679561', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs11656151', 'p_SMR_multi': 6.279704e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002230586}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.171 | Q11 | Are there any RP11-603J24.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-603J24.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-603J24.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.307 | Q11 | Are there any LMNB2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LMNB2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LMNB2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1957 | Q11 | Are there any CEACAM19 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CEACAM19 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs714948
• Cortex: Adjusted SMR multi-SNP P-value: 6.32e-13; HEIDI: 4.2761e-06
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.46e-11; HEIDI: 2.5441e-12
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.51e-09; HEIDI: 1.3292e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 9.36e-08; HEIDI: -9.9990e+03
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.73e-07; HEIDI: -9.9990e+03
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.81e-07; HEIDI: 3.6737e-02
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 3.02e-07; HEIDI: 8.7130e-03
• Hypothalamus: Adjusted SMR multi-SNP P-value: 4.16e-07; HEIDI: -9.9990e+03
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.58e-07; HEIDI: 1.7151e-02
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 9.19e-07; HEIDI: -9.9990e+03
• Amygdala: Adjusted SMR multi-SNP P-value: 1.90e-06; HEIDI: -9.9990e+03
• rs2965159
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.00e-11; HEIDI: 2.0401e-05
• rs56261258
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.46e-08; HEIDI: -9.9990e+03
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.35e-08; HEIDI: 1.1585e-01
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.02e-08; HEIDI: 1.4349e-02
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.37e-07; HEIDI: -9.9990e+03
• rs3760624
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.70e-07; HEIDI: 1.3958e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CEACAM19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1108029', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 6.324417e-13, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.276112e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1503903', 'Gene': 'CEACAM19', 'topRSID': 'rs2965159', 'p_SMR_multi': 1.002326e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.040128e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1397644', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 2.458889e-11, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.544115e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1690531', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 9.50635e-09, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.1329184}, {'UUID': 'NDD_SMR_genes_all_update_text_1268424', 'Gene': 'CEACAM19', 'topRSID': 'rs56261258', 'p_SMR_multi': 1.4619e-08, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1203796', 'Gene': 'CEACAM19', 'topRSID': 'rs56261258', 'p_SMR_multi': 2.346122e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.1158474}, {'UUID': 'NDD_SMR_genes_all_update_text_4008', 'Gene': 'CEACAM19', 'topRSID': 'rs56261258', 'p_SMR_multi': 3.024112e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.01434878}, {'UUID': 'NDD_SMR_genes_all_update_text_1247434', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 5.549269e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1717663', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 9.358195e-08, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1343793', 'Gene': 'CEACAM19', 'topRSID': 'rs3760624', 'p_SMR_multi': 1.704695e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0001395805}, {'UUID': 'NDD_SMR_genes_all_update_text_1157464', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 1.72853e-07, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1378751', 'Gene': 'CEACAM19', 'topRSID': 'rs56261258', 'p_SMR_multi': 2.368238e-07, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1611534', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 2.809066e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.03673705}, {'UUID': 'NDD_SMR_genes_all_update_text_1175009', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 3.01835e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.008712987}, {'UUID': 'NDD_SMR_genes_all_update_text_1454558', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 4.158688e-07, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1653156', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 8.575738e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01715121}, {'UUID': 'NDD_SMR_genes_all_update_text_1480339', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 9.187512e-07, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1598392', 'Gene': 'CEACAM19', 'topRSID': 'rs714948', 'p_SMR_multi': 1.898209e-06, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1105 | Q11 | Are there any SLC4A11 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Hippocampus, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SLC4A11 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SLC4A11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1925 | Q11 | Are there any RP11-326C3.13 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-326C3.13 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-326C3.13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1038 | Q11 | Are there any MIR320B1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene MIR320B1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MIR320B1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.658 | Q11 | Are there any LCT SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LCT that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LCT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.373 | Q11 | Are there any XXbac-B476C20.10 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene XXbac-B476C20.10 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'XXbac-B476C20.10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1661 | Q11 | Are there any GPR4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene GPR4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GPR4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1513 | Q11 | Are there any PLSCR2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PLSCR2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PLSCR2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.778 | Q11 | Are there any SAA4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene SAA4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SAA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.328 | Q11 | Are there any TMEM259 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TMEM259 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2240160
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.82e-08; HEIDI: 1.6814e-05
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.69e-08; HEIDI: 9.9579e-07
• rs7146
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.09e-06; HEIDI: 2.4562e-07
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TMEM259' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1397179', 'Gene': 'TMEM259', 'topRSID': 'rs2240160', 'p_SMR_multi': 4.824267e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.681359e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1503130', 'Gene': 'TMEM259', 'topRSID': 'rs2240160', 'p_SMR_multi': 8.691015e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.95789e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_634270', 'Gene': 'TMEM259', 'topRSID': 'rs7146', 'p_SMR_multi': 2.088724e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.456186e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1988 | Q11 | Are there any SYT9 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Cerebellar Hemisphere samples tested there are no SNPs within the gene SYT9 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SYT9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1924 | Q11 | Are there any AP000355.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AP000355.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AP000355.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.931 | Q11 | Are there any GATA6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GATA6 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GATA6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.188 | Q11 | Are there any RP11-70F11.8 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-70F11.8 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-70F11.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1595 | Q11 | Are there any MICALL1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Hippocampus, Whole Brain, Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene MICALL1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MICALL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.772 | Q11 | Are there any RP11-302L19.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-302L19.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-302L19.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1203 | Q11 | Are there any KRTAP4-5 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene KRTAP4-5 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'KRTAP4-5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.500 | Q11 | Are there any C2CD4C SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene C2CD4C that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'C2CD4C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1064 | Q11 | Are there any IGHV3-64 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the IGHV3-64 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2078690
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.63e-06; HEIDI: 1.5268e-08 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IGHV3-64' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500563', 'Gene': 'IGHV3-64', 'topRSID': 'rs2078690', 'p_SMR_multi': 2.629543e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.526755e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1111 | Q11 | Are there any TRIM40 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TRIM40 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs115938232
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.57e-07; HEIDI: 7.8207e-01
• rs114882073
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.83e-07; HEIDI: 7.9225e-01
• rs17184549
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.44e-06; HEIDI: 9.0900e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM40' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620281', 'Gene': 'TRIM40', 'topRSID': 'rs115938232', 'p_SMR_multi': 3.571278e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.7820669}, {'UUID': 'NDD_SMR_genes_all_update_text_620283', 'Gene': 'TRIM40', 'topRSID': 'rs114882073', 'p_SMR_multi': 4.832425e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.7922511}, {'UUID': 'NDD_SMR_genes_all_update_text_620284', 'Gene': 'TRIM40', 'topRSID': 'rs114882073', 'p_SMR_multi': 5.649683e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.7855498}, {'UUID': 'NDD_SMR_genes_all_update_text_620280', 'Gene': 'TRIM40', 'topRSID': 'rs114882073', 'p_SMR_multi': 7.569933e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.870899}, {'UUID': 'NDD_SMR_genes_all_update_text_620285', 'Gene': 'TRIM40', 'topRSID': 'rs17184549', 'p_SMR_multi': 1.439014e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.090028e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_620279', 'Gene': 'TRIM40', 'topRSID': 'rs114882073', 'p_SMR_multi': 1.516282e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.7334653}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.536 | Q11 | Are there any L2HGDH SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Brain and Cerebellum samples tested there are no SNPs within the gene L2HGDH that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'L2HGDH' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1601 | Q11 | Are there any C16orf88 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene C16orf88 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C16orf88' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.752 | Q11 | Are there any CRYGD SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene CRYGD that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CRYGD' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1933 | Q11 | Are there any FRMD6-AS2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FRMD6-AS2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FRMD6-AS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1367 | Q11 | Are there any C1QTNF6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene C1QTNF6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C1QTNF6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1444 | Q11 | Are there any CRHR1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the CRHR1 gene has 6 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.92e-34; HEIDI: 1.4644e-09
• rs393152
• Cortex: Adjusted SMR multi-SNP P-value: 1.15e-20; HEIDI: 2.1426e-17
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.11e-08; HEIDI: -9.9990e+03
• rs2074404
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.20e-20; HEIDI: 2.1402e-05
• rs12373139
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.15e-18; HEIDI: 2.1913e-01
• rs8070723
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.87e-11; HEIDI: 1.4097e-06
• rs173365
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.73e-08; HEIDI: 5.7327e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CRHR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041722', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.917855e-34, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.464444e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1041721', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.742656e-24, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.552425e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041720', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_SMR_multi': 5.624302000000001e-23, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.073966e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1154394', 'Gene': 'CRHR1', 'topRSID': 'rs393152', 'p_SMR_multi': 1.1510289999999999e-20, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.1426280000000002e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1041719', 'Gene': 'CRHR1', 'topRSID': 'rs2074404', 'p_SMR_multi': 2.195394e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.140171e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_560849', 'Gene': 'CRHR1', 'topRSID': 'rs12373139', 'p_SMR_multi': 5.146795e-18, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2191273}, {'UUID': 'NDD_SMR_genes_all_update_text_1041725', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.341036e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1087194}, {'UUID': 'NDD_SMR_genes_all_update_text_1336289', 'Gene': 'CRHR1', 'topRSID': 'rs8070723', 'p_SMR_multi': 3.865028e-11, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.409749e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041723', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.410259e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3500976}, {'UUID': 'NDD_SMR_genes_all_update_text_560848', 'Gene': 'CRHR1', 'topRSID': 'rs393152', 'p_SMR_multi': 3.109126e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041724', 'Gene': 'CRHR1', 'topRSID': 'rs173365', 'p_SMR_multi': 5.734197e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.732694e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.178 | Q11 | Are there any AGFG2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AGFG2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2734897
• Cerebellum: Adjusted SMR multi-SNP P-value: 7.44e-08; HEIDI: 2.1522e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AGFG2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1687938', 'Gene': 'AGFG2', 'topRSID': 'rs2734897', 'p_SMR_multi': 7.442622e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.2152247}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.470 | Q11 | Are there any CTD-2313N18.5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene CTD-2313N18.5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-2313N18.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1337 | Q11 | Are there any RP11-345J13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Prefrontal Cortex, Cortex and Whole Brain samples tested there are no SNPs within the gene RP11-345J13.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-345J13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1611 | Q11 | Are there any PRTG SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PRTG that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PRTG' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.126 | Q11 | Are there any KCTD13 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KCTD13 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11150575
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.41e-07; HEIDI: 1.8929e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KCTD13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501437', 'Gene': 'KCTD13', 'topRSID': 'rs11150575', 'p_SMR_multi': 9.41262e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01892866}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.355 | Q11 | Are there any FAM162A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FAM162A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM162A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.388 | Q11 | Are there any RP11-1049H7.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-1049H7.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-1049H7.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1435 | Q11 | Are there any RPL39P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RPL39P gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs17462136
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.77e-09; HEIDI: 8.2374e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RPL39P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504671', 'Gene': 'RPL39P', 'topRSID': 'rs17462136', 'p_SMR_multi': 1.767814e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08237445}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1007 | Q11 | Are there any DPPA4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene DPPA4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DPPA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.894 | Q11 | Are there any LILRB2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LILRB2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12984962
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.20e-06; HEIDI: 9.6295e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LILRB2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504179', 'Gene': 'LILRB2', 'topRSID': 'rs12984962', 'p_SMR_multi': 1.202451e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.629543e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1495 | Q11 | Are there any NUCKS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NUCKS1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs823111
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.99e-06; HEIDI: 1.0718e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NUCKS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1553466', 'Gene': 'NUCKS1', 'topRSID': 'rs823111', 'p_SMR_multi': 1.985706e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.071844e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.335 | Q11 | Are there any DAP SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene DAP that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'DAP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.975 | Q11 | Are there any LOC283174 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the LOC283174 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs35375713
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.08e-08; HEIDI: 1.2405e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LOC283174' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_470333', 'Gene': 'LOC283174', 'topRSID': 'rs35375713', 'p_SMR_multi': 9.076681e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.240492e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.197 | Q11 | Are there any GFM1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra and Anterior Cingulate Cortex BA24 samples tested there are no SNPs within the gene GFM1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GFM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.520 | Q11 | Are there any TRIM27 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TRIM27 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs142403264
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.07e-07; HEIDI: 7.1461e-02
• rs3129102
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.91e-07; HEIDI: 1.3040e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM27' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494677', 'Gene': 'TRIM27', 'topRSID': 'rs142403264', 'p_SMR_multi': 4.067407e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07146082}, {'UUID': 'NDD_SMR_genes_all_update_text_619748', 'Gene': 'TRIM27', 'topRSID': 'rs3129102', 'p_SMR_multi': 4.907539e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001304001}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.459 | Q11 | Are there any RP11-467L13.5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-467L13.5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-467L13.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1714 | Q11 | Are there any RRP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RRP1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RRP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.326 | Q11 | Are there any FAM167A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene FAM167A that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM167A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1323 | Q11 | Are there any ARL17A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the ARL17A gene has 7 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs1981997
• Cortex: Adjusted SMR multi-SNP P-value: 9.73e-46; HEIDI: 5.6019e-32
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.38e-20; HEIDI: 1.0782e-14
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 4.03e-17; HEIDI: 3.8785e-11
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.86e-15; HEIDI: 2.7867e-13
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.69e-14; HEIDI: 9.9820e-08
• rs12373139
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.40e-32; HEIDI: -9.9990e+03
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.90e-19; HEIDI: 1.4362e-07
• rs393152
• Cerebellum: Adjusted SMR multi-SNP P-value: 7.06e-30; HEIDI: 1.3599e-15
• Hippocampus: Adjusted SMR multi-SNP P-value: 4.36e-15; HEIDI: 6.2719e-08
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.74e-13; HEIDI: 3.6483e-08
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 1.20e-10; HEIDI: 1.3433e-07
• Amygdala: Adjusted SMR multi-SNP P-value: 6.08e-09; HEIDI: 6.8247e-02
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.53e-25; HEIDI: 4.8419e-10
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.34e-13; HEIDI: 9.2953e-06
• Liver: Adjusted SMR multi-SNP P-value: 5.35e-11; HEIDI: 2.2513e-04
• rs169201
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.96e-19; HEIDI: 2.9290e-12
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.48e-14; HEIDI: 1.3667e-05
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.14e-10; HEIDI: 2.4061e-05
• rs11012
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.70e-14; HEIDI: 2.6983e-19
• rs242557
• Spinalcord: Adjusted SMR multi-SNP P-value: 1.11e-10; HEIDI: 4.4074e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ARL17A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154401', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 9.72687e-46, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.601894e-32}, {'UUID': 'NDD_SMR_genes_all_update_text_1444276', 'Gene': 'ARL17A', 'topRSID': 'rs12373139', 'p_SMR_multi': 3.401272e-32, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_22221', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 7.062669e-30, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.359857e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1579430', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.525507e-25, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.841893e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1041774', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 9.278724e-23, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.813254e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1714164', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.381192e-20, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.078224e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1194224', 'Gene': 'ARL17A', 'topRSID': 'rs169201', 'p_SMR_multi': 2.958366e-19, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 2.929042e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1375937', 'Gene': 'ARL17A', 'topRSID': 'rs12373139', 'p_SMR_multi': 9.895627e-19, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.436227e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1264990', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.9211510000000004e-18, 'Omic_tissue': 'Cortex', 'p_HEIDI': 1.20168e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1684942', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 3.946778e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.870126e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1170880', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.025226e-17, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 3.878461e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_33475', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 4.356716e-15, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 6.27192e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1732403', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.864917e-15, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 2.786689e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1464425', 'Gene': 'ARL17A', 'topRSID': 'rs169201', 'p_SMR_multi': 1.483906e-14, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 1.366676e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1646051', 'Gene': 'ARL17A', 'topRSID': 'rs11012', 'p_SMR_multi': 3.695756e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.698306e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1283711', 'Gene': 'ARL17A', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.692457e-14, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 9.982045e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1336299', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.33843e-13, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 9.295266e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_27916', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 4.735415e-13, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 3.648343e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1478194', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 5.347998e-11, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.0002251332}, {'UUID': 'NDD_SMR_genes_all_update_text_30485', 'Gene': 'ARL17A', 'topRSID': 'rs242557', 'p_SMR_multi': 1.114835e-10, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 0.04407374}, {'UUID': 'NDD_SMR_genes_all_update_text_1489545', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 1.200902e-10, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 1.343332e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1596830', 'Gene': 'ARL17A', 'topRSID': 'rs169201', 'p_SMR_multi': 4.135643e-10, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 2.406068e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1388488', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 1.180288e-09, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.0002707562}, {'UUID': 'NDD_SMR_genes_all_update_text_1604720', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 6.079622e-09, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.06824737}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.269 | Q11 | Are there any AC018865.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Hippocampus and Cerebellum samples tested there are no SNPs within the gene AC018865.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC018865.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.799 | Q11 | Are there any ADAMTS4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ADAMTS4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs34884997
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.30e-06; HEIDI: 1.3417e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADAMTS4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_654684', 'Gene': 'ADAMTS4', 'topRSID': 'rs34884997', 'p_SMR_multi': 2.296954e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00134174}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1432 | Q11 | Are there any SPG11 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SPG11 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SPG11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.70 | Q11 | Are there any C14orf180 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Caudate Basal Ganglia samples tested there are no SNPs within the gene C14orf180 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C14orf180' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.938 | Q11 | Are there any AC008984.7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AC008984.7 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs35915840
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.28e-06; HEIDI: 5.1750e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC008984.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504181', 'Gene': 'AC008984.7', 'topRSID': 'rs35915840', 'p_SMR_multi': 1.27783e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05174984}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1447 | Q11 | Are there any ZNF285 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Liver, Whole Blood, Whole Brain and Cerebellum samples tested there are no SNPs within the gene ZNF285 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZNF285' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1782 | Q11 | Are there any FAM160A1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FAM160A1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM160A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.468 | Q11 | Are there any GAS6-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene GAS6-AS1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GAS6-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1396 | Q11 | Are there any GFPT1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene GFPT1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GFPT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1614 | Q11 | Are there any LINC00657 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LINC00657 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LINC00657' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.549 | Q11 | Are there any NUP98 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Liver samples tested there are no SNPs within the gene NUP98 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'NUP98' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.538 | Q11 | Are there any MAPT SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the MAPT gene has 36 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs570200944
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 9.25e-16; HEIDI: 2.6946e-03
• rs62055936
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.65e-15; HEIDI: -9.9990e+03
• rs62063271
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.38e-15; HEIDI: 2.3680e-06
• rs112572874
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.61e-14; HEIDI: 3.5579e-04
• rs62056790
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.86e-14; HEIDI: 1.6329e-05
• rs112155389
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.70e-14; HEIDI: 1.3789e-04
• rs17652121
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.73e-14; HEIDI: 4.4160e-02
• rs10445338
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.08e-14; HEIDI: 2.0531e-03
• rs17689882
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.20e-14; HEIDI: 2.3688e-03
• rs111541901
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.20e-14; HEIDI: 7.4432e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MAPT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242273', 'Gene': 'MAPT', 'topRSID': 'rs570200944', 'p_SMR_multi': 9.246003e-16, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002694627}, {'UUID': 'NDD_SMR_genes_all_update_text_1435916', 'Gene': 'MAPT', 'topRSID': 'rs62055936', 'p_SMR_multi': 2.654211e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948891', 'Gene': 'MAPT', 'topRSID': 'rs62063271', 'p_SMR_multi': 6.382411e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.368028e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_948886', 'Gene': 'MAPT', 'topRSID': 'rs62063271', 'p_SMR_multi': 9.216278e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.048429e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_948890', 'Gene': 'MAPT', 'topRSID': 'rs112572874', 'p_SMR_multi': 1.611413e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003557865}, {'UUID': 'NDD_SMR_genes_all_update_text_948898', 'Gene': 'MAPT', 'topRSID': 'rs62056790', 'p_SMR_multi': 1.857436e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.632861e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948885', 'Gene': 'MAPT', 'topRSID': 'rs62063271', 'p_SMR_multi': 2.112358e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.000657e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948880', 'Gene': 'MAPT', 'topRSID': 'rs112155389', 'p_SMR_multi': 3.704633e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001378912}, {'UUID': 'NDD_SMR_genes_all_update_text_491114', 'Gene': 'MAPT', 'topRSID': 'rs17652121', 'p_SMR_multi': 4.729064e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04416005}, {'UUID': 'NDD_SMR_genes_all_update_text_491124', 'Gene': 'MAPT', 'topRSID': 'rs10445338', 'p_SMR_multi': 5.075702e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.002053087}, {'UUID': 'NDD_SMR_genes_all_update_text_948892', 'Gene': 'MAPT', 'topRSID': 'rs17689882', 'p_SMR_multi': 5.198464e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002368768}, {'UUID': 'NDD_SMR_genes_all_update_text_948899', 'Gene': 'MAPT', 'topRSID': 'rs111541901', 'p_SMR_multi': 5.204226e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007443227}, {'UUID': 'NDD_SMR_genes_all_update_text_491126', 'Gene': 'MAPT', 'topRSID': 'rs17651483', 'p_SMR_multi': 8.260037e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.00727617}, {'UUID': 'NDD_SMR_genes_all_update_text_948878', 'Gene': 'MAPT', 'topRSID': 'rs62063271', 'p_SMR_multi': 9.762326e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001780349}, {'UUID': 'NDD_SMR_genes_all_update_text_491118', 'Gene': 'MAPT', 'topRSID': 'rs17650872', 'p_SMR_multi': 1.092641e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.002948095}, {'UUID': 'NDD_SMR_genes_all_update_text_491119', 'Gene': 'MAPT', 'topRSID': 'rs17650872', 'p_SMR_multi': 1.722374e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01447168}, {'UUID': 'NDD_SMR_genes_all_update_text_491121', 'Gene': 'MAPT', 'topRSID': 'rs56294117', 'p_SMR_multi': 2.351202e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.007402329}, {'UUID': 'NDD_SMR_genes_all_update_text_491132', 'Gene': 'MAPT', 'topRSID': 'rs17574361', 'p_SMR_multi': 2.718451e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.06000518}, {'UUID': 'NDD_SMR_genes_all_update_text_491113', 'Gene': 'MAPT', 'topRSID': 'rs17652121', 'p_SMR_multi': 4.125124e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02329478}, {'UUID': 'NDD_SMR_genes_all_update_text_948893', 'Gene': 'MAPT', 'topRSID': 'rs2532233', 'p_SMR_multi': 7.248068e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001119682}, {'UUID': 'NDD_SMR_genes_all_update_text_491111', 'Gene': 'MAPT', 'topRSID': 'rs17652121', 'p_SMR_multi': 1.670464e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.005371693}, {'UUID': 'NDD_SMR_genes_all_update_text_1640220', 'Gene': 'MAPT', 'topRSID': 'rs62641967', 'p_SMR_multi': 6.975485e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.000110669}, {'UUID': 'NDD_SMR_genes_all_update_text_491117', 'Gene': 'MAPT', 'topRSID': 'rs62063296', 'p_SMR_multi': 9.006126e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.047431e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948881', 'Gene': 'MAPT', 'topRSID': 'rs112746008', 'p_SMR_multi': 4.724284e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001928245}, {'UUID': 'NDD_SMR_genes_all_update_text_491120', 'Gene': 'MAPT', 'topRSID': 'rs17650901', 'p_SMR_multi': 1.154109e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.005037148}, {'UUID': 'NDD_SMR_genes_all_update_text_491105', 'Gene': 'MAPT', 'topRSID': 'rs9303523', 'p_SMR_multi': 1.654896e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.06329188}, {'UUID': 'NDD_SMR_genes_all_update_text_491128', 'Gene': 'MAPT', 'topRSID': 'rs1991556', 'p_SMR_multi': 2.066811e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.006641753}, {'UUID': 'NDD_SMR_genes_all_update_text_948876', 'Gene': 'MAPT', 'topRSID': 'rs112995313', 'p_SMR_multi': 2.078808e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1171783}, {'UUID': 'NDD_SMR_genes_all_update_text_491102', 'Gene': 'MAPT', 'topRSID': 'rs78599197', 'p_SMR_multi': 2.726787e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491101', 'Gene': 'MAPT', 'topRSID': 'rs2435204', 'p_SMR_multi': 3.399693e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491130', 'Gene': 'MAPT', 'topRSID': 'rs41543317', 'p_SMR_multi': 7.032091e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.461049e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_948879', 'Gene': 'MAPT', 'topRSID': 'rs112995313', 'p_SMR_multi': 1.143419e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001881827}, {'UUID': 'NDD_SMR_genes_all_update_text_491122', 'Gene': 'MAPT', 'topRSID': 'rs3785884', 'p_SMR_multi': 1.195731e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1378246}, {'UUID': 'NDD_SMR_genes_all_update_text_491104', 'Gene': 'MAPT', 'topRSID': 'rs55780945', 'p_SMR_multi': 1.360462e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948895', 'Gene': 'MAPT', 'topRSID': 'rs111970616', 'p_SMR_multi': 1.515582e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007845302}, {'UUID': 'NDD_SMR_genes_all_update_text_491116', 'Gene': 'MAPT', 'topRSID': 'rs62063859', 'p_SMR_multi': 1.715358e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1586649}, {'UUID': 'NDD_SMR_genes_all_update_text_491125', 'Gene': 'MAPT', 'topRSID': 'rs62063779', 'p_SMR_multi': 2.173606e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.0931e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948894', 'Gene': 'MAPT', 'topRSID': 'rs112746008', 'p_SMR_multi': 2.267194e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001222378}, {'UUID': 'NDD_SMR_genes_all_update_text_948896', 'Gene': 'MAPT', 'topRSID': 'rs62056790', 'p_SMR_multi': 8.713737e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000523165}, {'UUID': 'NDD_SMR_genes_all_update_text_491103', 'Gene': 'MAPT', 'topRSID': 'rs56189701', 'p_SMR_multi': 1.831195e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3550347}, {'UUID': 'NDD_SMR_genes_all_update_text_948888', 'Gene': 'MAPT', 'topRSID': 'rs112155389', 'p_SMR_multi': 3.214215e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001107993}, {'UUID': 'NDD_SMR_genes_all_update_text_948883', 'Gene': 'MAPT', 'topRSID': 'rs112197756', 'p_SMR_multi': 3.651536e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2790191}, {'UUID': 'NDD_SMR_genes_all_update_text_491131', 'Gene': 'MAPT', 'topRSID': 'rs41543317', 'p_SMR_multi': 1.265537e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.774719e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_491100', 'Gene': 'MAPT', 'topRSID': 'rs55780945', 'p_SMR_multi': 1.290922e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2039012}, {'UUID': 'NDD_SMR_genes_all_update_text_491107', 'Gene': 'MAPT', 'topRSID': 'rs17651507', 'p_SMR_multi': 1.827655e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01714676}, {'UUID': 'NDD_SMR_genes_all_update_text_948875', 'Gene': 'MAPT', 'topRSID': 'rs538628', 'p_SMR_multi': 2.377791e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00549726}, {'UUID': 'NDD_SMR_genes_all_update_text_948884', 'Gene': 'MAPT', 'topRSID': 'rs9899833', 'p_SMR_multi': 3.484812e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009542574}, {'UUID': 'NDD_SMR_genes_all_update_text_948877', 'Gene': 'MAPT', 'topRSID': 'rs538628', 'p_SMR_multi': 3.780578e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003473264}, {'UUID': 'NDD_SMR_genes_all_update_text_948882', 'Gene': 'MAPT', 'topRSID': 'rs112197756', 'p_SMR_multi': 5.55306e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1464477}, {'UUID': 'NDD_SMR_genes_all_update_text_491115', 'Gene': 'MAPT', 'topRSID': 'rs62063859', 'p_SMR_multi': 6.786937e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1094086}, {'UUID': 'NDD_SMR_genes_all_update_text_491108', 'Gene': 'MAPT', 'topRSID': 'rs9944484', 'p_SMR_multi': 8.711477e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.54731e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_491109', 'Gene': 'MAPT', 'topRSID': 'rs9944484', 'p_SMR_multi': 1.10509e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.430408e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1230 | Q11 | Are there any STH SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the STH gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11079718
• Cortex: Adjusted SMR multi-SNP P-value: 9.43e-08; HEIDI: 7.1870e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'STH' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1147255', 'Gene': 'STH', 'topRSID': 'rs11079718', 'p_SMR_multi': 9.425613e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.7186979}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.957 | Q11 | Are there any REXO1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the REXO1 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4453627
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.02e-08; HEIDI: 2.4083e-05
• rs12460105
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.68e-07; HEIDI: 9.7610e-04
• rs12976128
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.23e-06; HEIDI: 1.0811e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'REXO1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_634424', 'Gene': 'REXO1', 'topRSID': 'rs4453627', 'p_SMR_multi': 2.017244e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.408255e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_634421', 'Gene': 'REXO1', 'topRSID': 'rs12460105', 'p_SMR_multi': 2.679486e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0009761002}, {'UUID': 'NDD_SMR_genes_all_update_text_119552', 'Gene': 'REXO1', 'topRSID': 'rs12976128', 'p_SMR_multi': 1.225713e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01081071}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1635 | Q11 | Are there any CCT6P2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CCT6P2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CCT6P2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1418 | Q11 | Are there any RP11-259G18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-259G18.1 gene has 5 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.86e-40; HEIDI: 8.0707e-11
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 1.59e-11; HEIDI: 2.9000e-08
• rs1981997
• Cerebellum: Adjusted SMR multi-SNP P-value: 6.40e-23; HEIDI: 3.5744e-25
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 8.05e-21; HEIDI: 4.6765e-22
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.95e-14; HEIDI: 4.4914e-14
• Cortex: Adjusted SMR multi-SNP P-value: 6.87e-14; HEIDI: 5.2965e-12
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.59e-11; HEIDI: 3.9211e-09
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 8.00e-11; HEIDI: 1.4897e-06
• Amygdala: Adjusted SMR multi-SNP P-value: 1.75e-09; HEIDI: 1.7212e-07
• Hypothalamus: Adjusted SMR multi-SNP P-value: 6.57e-08; HEIDI: 4.3479e-05
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.46e-07; HEIDI: 3.7821e-03
• rs12373139
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.16e-14; HEIDI: 9.2177e-09
• rs1635291
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.11e-13; HEIDI: 2.5386e-07
• rs11012
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.69e-11; HEIDI: 8.4899e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-259G18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579425', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs169201', 'p_SMR_multi': 4.864652e-40, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.070724e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1714159', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.403575000000001e-23, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 3.5744260000000003e-25}, {'UUID': 'NDD_SMR_genes_all_update_text_1194220', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 8.051304e-21, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 4.676515e-22}, {'UUID': 'NDD_SMR_genes_all_update_text_1336294', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.15822e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 9.217704e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1732398', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.946116e-14, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 4.491428e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1264985', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.872455e-14, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.296527e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1283706', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1635291', 'p_SMR_multi': 1.111834e-13, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 2.538554e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1596825', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.585219e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 3.921059e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1489541', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.593055e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 2.899964e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1170876', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 7.996462e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 1.489663e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1646047', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs11012', 'p_SMR_multi': 9.688991e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.08489879}, {'UUID': 'NDD_SMR_genes_all_update_text_1604716', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.745554e-09, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 1.721168e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1464421', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.568266e-08, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 4.347853e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1375932', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.463815e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.003782056}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.422 | Q11 | Are there any CEP97 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene CEP97 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CEP97' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1935 | Q11 | Are there any CTD-2554C21.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Substantia nigra and Putamen Basal Ganglia samples tested there are no SNPs within the gene CTD-2554C21.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-2554C21.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1532 | Q11 | Are there any ACTR1B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene ACTR1B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ACTR1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1580 | Q11 | Are there any TRBV6-6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV6-6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TRBV6-6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1659 | Q11 | Are there any VPS33B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene VPS33B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'VPS33B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1116 | Q11 | Are there any SMG5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene SMG5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SMG5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.722 | Q11 | Are there any RP11-127B20.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-127B20.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-127B20.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1247 | Q11 | Are there any TCN1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TCN1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12419784
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.99e-13; HEIDI: 4.9939e-07 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TCN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498258', 'Gene': 'TCN1', 'topRSID': 'rs12419784', 'p_SMR_multi': 6.992786e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.993905e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1236 | Q11 | Are there any C11orf74 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene C11orf74 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C11orf74' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1076 | Q11 | Are there any UNC5CL SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the UNC5CL gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs10155663
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.08e-09; HEIDI: 2.3538e-04
• rs736795
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.87e-08; HEIDI: 4.7338e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UNC5CL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622627', 'Gene': 'UNC5CL', 'topRSID': 'rs10155663', 'p_SMR_multi': 9.082427e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002353766}, {'UUID': 'NDD_SMR_genes_all_update_text_622628', 'Gene': 'UNC5CL', 'topRSID': 'rs736795', 'p_SMR_multi': 3.869352e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0004733802}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1907 | Q11 | Are there any KRTAP4-5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene KRTAP4-5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KRTAP4-5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.264 | Q11 | Are there any STOML3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene STOML3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'STOML3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1437 | Q11 | Are there any RP11-349A22.5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP11-349A22.5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-349A22.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1339 | Q11 | Are there any KPTN SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene KPTN that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'KPTN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.243 | Q11 | Are there any RP11-259G18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-259G18.2 gene has 15 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.07e-15; HEIDI: 7.3487e-05
• rs17661015
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.21e-14; HEIDI: -9.9990e+03
• rs199528
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.31e-14; HEIDI: 5.3473e-09
• rs2532363
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 8.57e-13; HEIDI: -9.9990e+03
• rs62056812
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.27e-12; HEIDI: -9.9990e+03
• rs62055938
• Liver: Adjusted SMR multi-SNP P-value: 1.11e-11; HEIDI: -9.9990e+03
• rs55974014
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.30e-11; HEIDI: 2.7153e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 5.84e-11; HEIDI: 3.2943e-01
• rs17763086
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.83e-11; HEIDI: -9.9990e+03
• rs62055888
• Cortex: Adjusted SMR multi-SNP P-value: 1.95e-11; HEIDI: -9.9990e+03
• rs199533
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.36e-11; HEIDI: 4.1194e-02
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 9.75e-11; HEIDI: 5.9934e-02
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.02e-10; HEIDI: 5.1366e-04
• Amygdala: Adjusted SMR multi-SNP P-value: 3.78e-10; HEIDI: 3.5452e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-259G18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564786', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs2532233', 'p_SMR_multi': 7.067652e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.348686e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1679567', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs17661015', 'p_SMR_multi': 1.207465e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640223', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199528', 'p_SMR_multi': 4.312892e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.347335e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1328935', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs2532363', 'p_SMR_multi': 8.566808e-13, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710351', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62056812', 'p_SMR_multi': 4.265463e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1476428', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62055938', 'p_SMR_multi': 1.107504e-11, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1730066', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.298891e-11, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.2715299}, {'UUID': 'NDD_SMR_genes_all_update_text_1191173', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs17763086', 'p_SMR_multi': 1.833659e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262226', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62055888', 'p_SMR_multi': 1.951413e-11, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1281356', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199533', 'p_SMR_multi': 2.361642e-11, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.04119357}, {'UUID': 'NDD_SMR_genes_all_update_text_1386992', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199456', 'p_SMR_multi': 5.526697e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.01264907}, {'UUID': 'NDD_SMR_genes_all_update_text_1168836', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.837979e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.3294297}, {'UUID': 'NDD_SMR_genes_all_update_text_1594925', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62061822', 'p_SMR_multi': 7.965025e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.6651587}, {'UUID': 'NDD_SMR_genes_all_update_text_1488141', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199533', 'p_SMR_multi': 9.748174e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.05993414}, {'UUID': 'NDD_SMR_genes_all_update_text_1462896', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199533', 'p_SMR_multi': 1.020137e-10, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.0005136639}, {'UUID': 'NDD_SMR_genes_all_update_text_1603777', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199533', 'p_SMR_multi': 3.781583e-10, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.03545202}, {'UUID': 'NDD_SMR_genes_all_update_text_491154', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs578109777', 'p_SMR_multi': 5.445399e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1451664', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs9468', 'p_SMR_multi': 1.121136e-08, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242278', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199498', 'p_SMR_multi': 4.701768e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.000900226}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1010 | Q11 | Are there any WDR18 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the WDR18 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2365709
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.02e-12; HEIDI: 9.4913e-03
• rs2240149
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.87e-07; HEIDI: 1.0819e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'WDR18' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503128', 'Gene': 'WDR18', 'topRSID': 'rs2365709', 'p_SMR_multi': 8.020548e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009491298}, {'UUID': 'NDD_SMR_genes_all_update_text_1397178', 'Gene': 'WDR18', 'topRSID': 'rs2240149', 'p_SMR_multi': 4.865151e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.001081871}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.685 | Q11 | Are there any AC111200.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC111200.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC111200.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1268 | Q11 | Are there any MZB1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene MZB1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MZB1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1475 | Q11 | Are there any C10orf62 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene C10orf62 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C10orf62' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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