uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.554 | Q11 | Are there any ENOSF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Liver, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ENOSF1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ENOSF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.763 | Q11 | Are there any DDX6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus and Whole Blood samples tested there are no SNPs within the gene DDX6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'DDX6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.304 | Q11 | Are there any RP4-809F18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene RP4-809F18.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP4-809F18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1878 | Q11 | Are there any RP11-707O23.5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-707O23.5 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62066086
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.93e-07; HEIDI: -9.9990e+03
• rs2732705
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 8.70e-07; HEIDI: 2.2845e-02
• rs55974014
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.25e-06; HEIDI: -9.9990e+03
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.54e-06; HEIDI: 6.6050e-01
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.54e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-707O23.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_115148', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs62066086', 'p_SMR_multi': 5.929465e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1203002', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs2732705', 'p_SMR_multi': 8.695728e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.02284462}, {'UUID': 'NDD_SMR_genes_all_update_text_1343150', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.245942e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1652496', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.540988e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6604964}, {'UUID': 'NDD_SMR_genes_all_update_text_1291755', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.544718e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_115147', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs62066086', 'p_SMR_multi': 2.932925e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1093 | Q11 | Are there any EXOC3L2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the EXOC3L2 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs112668741
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.91e-13; HEIDI: 1.8519e-02
• rs41561512
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.29e-07; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EXOC3L2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122492', 'Gene': 'EXOC3L2', 'topRSID': 'rs112668741', 'p_SMR_multi': 7.908852e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01851876}, {'UUID': 'NDD_SMR_genes_all_update_text_637468', 'Gene': 'EXOC3L2', 'topRSID': 'rs41561512', 'p_SMR_multi': 3.293403e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1747 | Q11 | Are there any PAXBP1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PAXBP1-AS1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PAXBP1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1652 | Q11 | Are there any C10orf96 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene C10orf96 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C10orf96' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.914 | Q11 | Are there any ZYG11B SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ZYG11B that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ZYG11B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1932 | Q11 | Are there any BAG2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BAG2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'BAG2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.275 | Q11 | Are there any GCKR SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GCKR that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'GCKR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1147 | Q11 | Are there any CTD-2091N23.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene CTD-2091N23.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-2091N23.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1589 | Q11 | Are there any RWDD2A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene RWDD2A that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RWDD2A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.700 | Q11 | Are there any MTND1P24 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene MTND1P24 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MTND1P24' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1765 | Q11 | Are there any SCARB2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SCARB2 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs13111888
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.94e-08; HEIDI: 1.2227e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SCARB2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555890', 'Gene': 'SCARB2', 'topRSID': 'rs13111888', 'p_SMR_multi': 2.944265e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00122267}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.488 | Q11 | Are there any SLC18A1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Spinalcord, Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene SLC18A1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SLC18A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.428 | Q11 | Are there any AKR1B1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene AKR1B1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AKR1B1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.377 | Q11 | Are there any FCRL4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FCRL4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'FCRL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1008 | Q11 | Are there any CMAHP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus and Cerebellum samples tested there are no SNPs within the gene CMAHP that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CMAHP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1003 | Q11 | Are there any C9orf72 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | Yes, the C9orf72 gene has 9 SNPs that are statistically significant in Amyotrophic Lateral Sclerosis. Here are the SNPs along with their adjusted SMR p-values:
• rs774358
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.69e-22; HEIDI: 2.8038e-11
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.37e-18; HEIDI: 3.6488e-15
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.22e-14; HEIDI: 2.1925e-08
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 7.29e-14; HEIDI: 1.7215e-05
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.42e-09; HEIDI: 3.9589e-05
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 5.32e-09; HEIDI: 4.2822e-06
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.94e-08; HEIDI: 7.8958e-03
• Cortex: Adjusted SMR multi-SNP P-value: 4.08e-08; HEIDI: 2.1468e-03
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.65e-07; HEIDI: 5.5330e-03
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 9.77e-07; HEIDI: 1.7666e-03
• rs1031153
• Cortex: Adjusted SMR multi-SNP P-value: 3.69e-16; HEIDI: 8.6908e-08
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.52e-07; HEIDI: 5.1133e-03
• rs2492816
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.79e-15; HEIDI: 4.8667e-14
• rs13691
• Cerebellum: Adjusted SMR multi-SNP P-value: 5.57e-12; HEIDI: 1.3769e-04
• rs2282241
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.86e-11; HEIDI: 7.9714e-13
• rs10967976
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.79e-11; HEIDI: 1.3086e-04
• rs3736321
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.04e-11; HEIDI: 9.7205e-04
• rs9969832
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.71e-11; HEIDI: 6.8091e-01
• rs10967981
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.79e-07; HEIDI: 1.3189e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C9orf72' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1512421', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 6.686547e-22, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.803834e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1403105', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 8.368701e-18, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.648796e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1114010', 'Gene': 'C9orf72', 'topRSID': 'rs1031153', 'p_SMR_multi': 3.691435e-16, 'Omic_tissue': 'Cortex', 'p_HEIDI': 8.690788e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1209518', 'Gene': 'C9orf72', 'topRSID': 'rs2492816', 'p_SMR_multi': 1.789029e-15, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 4.866677e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1615729', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 4.220426e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.192468e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1297844', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 7.28505e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.721501e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_4374', 'Gene': 'C9orf72', 'topRSID': 'rs13691', 'p_SMR_multi': 5.567312e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0001376868}, {'UUID': 'NDD_SMR_genes_all_update_text_745097', 'Gene': 'C9orf72', 'topRSID': 'rs2282241', 'p_SMR_multi': 1.85908e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.971389e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1347657', 'Gene': 'C9orf72', 'topRSID': 'rs10967976', 'p_SMR_multi': 2.787489e-11, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0001308631}, {'UUID': 'NDD_SMR_genes_all_update_text_1719531', 'Gene': 'C9orf72', 'topRSID': 'rs3736321', 'p_SMR_multi': 6.035943e-11, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.000972053}, {'UUID': 'NDD_SMR_genes_all_update_text_745098', 'Gene': 'C9orf72', 'topRSID': 'rs9969832', 'p_SMR_multi': 6.714586e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6809056}, {'UUID': 'NDD_SMR_genes_all_update_text_1693433', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 1.424051e-09, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 3.958948e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1177377', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 5.323115e-09, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 4.282238e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1270356', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 2.939078e-08, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.007895794}, {'UUID': 'NDD_SMR_genes_all_update_text_1249608', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 4.080217e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.002146774}, {'UUID': 'NDD_SMR_genes_all_update_text_1159153', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 1.647233e-07, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.005533035}, {'UUID': 'NDD_SMR_genes_all_update_text_1656933', 'Gene': 'C9orf72', 'topRSID': 'rs10967981', 'p_SMR_multi': 1.787484e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01318933}, {'UUID': 'NDD_SMR_genes_all_update_text_1379984', 'Gene': 'C9orf72', 'topRSID': 'rs1031153', 'p_SMR_multi': 3.520575e-07, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.005113277}, {'UUID': 'NDD_SMR_genes_all_update_text_1586101', 'Gene': 'C9orf72', 'topRSID': 'rs774358', 'p_SMR_multi': 9.771533e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.001766621}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1940 | Q11 | Are there any OR52N2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Tibial Nerve samples tested there are no SNPs within the gene OR52N2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'OR52N2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.714 | Q11 | Are there any TRAK1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TRAK1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TRAK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1335 | Q11 | Are there any GAL3ST4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the GAL3ST4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11764176
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.26e-11; HEIDI: 1.7073e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GAL3ST4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495798', 'Gene': 'GAL3ST4', 'topRSID': 'rs11764176', 'p_SMR_multi': 4.262207e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.707258e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1156 | Q11 | Are there any RP11-214O1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-214O1.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-214O1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.338 | Q11 | Are there any PRKD2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene PRKD2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PRKD2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1343 | Q11 | Are there any NRDC SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene NRDC that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NRDC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1593 | Q11 | Are there any ZNF496 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ZNF496 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ZNF496' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1993 | Q11 | Are there any RMDN2-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RMDN2-AS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RMDN2-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.598 | Q11 | Are there any RP11-90C4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-90C4.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-90C4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.16 | Q11 | Are there any FBXO2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene FBXO2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FBXO2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1855 | Q11 | Are there any IGSF9B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the IGSF9B gene has 14 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs3802920
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.23e-10; HEIDI: 1.6256e-04
• rs1793680
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.07e-10; HEIDI: 6.0617e-03
• rs11223627
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.68e-10; HEIDI: 5.4113e-05
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.38e-10; HEIDI: 1.3597e-04
• rs12801289
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.83e-10; HEIDI: 1.0692e-02
• rs12574238
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.26e-10; HEIDI: 1.4388e-02
• rs329669
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.34e-10; HEIDI: 2.5581e-05
• rs11223621
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.60e-10; HEIDI: 4.2974e-02
• rs36086419
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.56e-09; HEIDI: 3.0771e-03
• rs2027788
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.44e-09; HEIDI: 4.3466e-02
• rs167915
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.59e-09; HEIDI: 1.1521e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IGSF9B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_961101', 'Gene': 'IGSF9B', 'topRSID': 'rs3802920', 'p_SMR_multi': 1.22563e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001625568}, {'UUID': 'NDD_SMR_genes_all_update_text_470339', 'Gene': 'IGSF9B', 'topRSID': 'rs1793680', 'p_SMR_multi': 2.071103e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.006061729}, {'UUID': 'NDD_SMR_genes_all_update_text_961111', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 2.684249e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.411344e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_470351', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 3.377487e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001359746}, {'UUID': 'NDD_SMR_genes_all_update_text_961104', 'Gene': 'IGSF9B', 'topRSID': 'rs12801289', 'p_SMR_multi': 4.832318e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01069246}, {'UUID': 'NDD_SMR_genes_all_update_text_470350', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 5.363224e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001584988}, {'UUID': 'NDD_SMR_genes_all_update_text_961103', 'Gene': 'IGSF9B', 'topRSID': 'rs12574238', 'p_SMR_multi': 6.255567e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01438832}, {'UUID': 'NDD_SMR_genes_all_update_text_470340', 'Gene': 'IGSF9B', 'topRSID': 'rs329669', 'p_SMR_multi': 6.343736e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.55807e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_961105', 'Gene': 'IGSF9B', 'topRSID': 'rs11223621', 'p_SMR_multi': 9.60378e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04297376}, {'UUID': 'NDD_SMR_genes_all_update_text_961112', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 1.318619e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002563586}, {'UUID': 'NDD_SMR_genes_all_update_text_961102', 'Gene': 'IGSF9B', 'topRSID': 'rs36086419', 'p_SMR_multi': 1.557496e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003077119}, {'UUID': 'NDD_SMR_genes_all_update_text_961110', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 2.306303e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00314323}, {'UUID': 'NDD_SMR_genes_all_update_text_470342', 'Gene': 'IGSF9B', 'topRSID': 'rs2027788', 'p_SMR_multi': 5.443586e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04346612}, {'UUID': 'NDD_SMR_genes_all_update_text_470341', 'Gene': 'IGSF9B', 'topRSID': 'rs167915', 'p_SMR_multi': 5.59005e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1152071}, {'UUID': 'NDD_SMR_genes_all_update_text_470352', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 6.343735e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2361532}, {'UUID': 'NDD_SMR_genes_all_update_text_961106', 'Gene': 'IGSF9B', 'topRSID': 'rs329667', 'p_SMR_multi': 6.660268e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4810449}, {'UUID': 'NDD_SMR_genes_all_update_text_961113', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 1.082809e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01711494}, {'UUID': 'NDD_SMR_genes_all_update_text_1561131', 'Gene': 'IGSF9B', 'topRSID': 'rs329673', 'p_SMR_multi': 1.196462e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001375262}, {'UUID': 'NDD_SMR_genes_all_update_text_470338', 'Gene': 'IGSF9B', 'topRSID': 'rs34845616', 'p_SMR_multi': 1.31293e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.003677258}, {'UUID': 'NDD_SMR_genes_all_update_text_961109', 'Gene': 'IGSF9B', 'topRSID': 'rs229285', 'p_SMR_multi': 3.238058e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1042465}, {'UUID': 'NDD_SMR_genes_all_update_text_470347', 'Gene': 'IGSF9B', 'topRSID': 'rs11223627', 'p_SMR_multi': 9.431815e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.05034639}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1634 | Q11 | Are there any PARP2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested there are no SNPs within the gene PARP2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PARP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1686 | Q11 | Are there any CASP6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene CASP6 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CASP6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.600 | Q11 | Are there any AC016999.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC016999.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC016999.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.924 | Q11 | Are there any RP11-398K22.12 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RP11-398K22.12 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-398K22.12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.471 | Q11 | Are there any PTRF SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PTRF that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PTRF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.202 | Q11 | Are there any TDRP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Cerebellar Hemisphere, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested there are no SNPs within the gene TDRP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TDRP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1206 | Q11 | Are there any HSD3B2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Cortex samples tested there are no SNPs within the gene HSD3B2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'HSD3B2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1056 | Q11 | Are there any MEF2B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MEF2B that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MEF2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1195 | Q11 | Are there any EXOSC3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene EXOSC3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'EXOSC3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1300 | Q11 | Are there any CTD-2126E3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene CTD-2126E3.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2126E3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1276 | Q11 | Are there any CTC-338M12.5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTC-338M12.5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTC-338M12.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1814 | Q11 | Are there any MTMR2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the MTMR2 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs530914
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.00e-07; HEIDI: 6.6544e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MTMR2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_545949', 'Gene': 'MTMR2', 'topRSID': 'rs530914', 'p_SMR_multi': 2.001927e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.6654426}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1402 | Q11 | Are there any LEPRE1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LEPRE1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LEPRE1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1807 | Q11 | Are there any WHAMMP2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene WHAMMP2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'WHAMMP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.661 | Q11 | Are there any TAS2R14 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TAS2R14 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TAS2R14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.560 | Q11 | Are there any YAF2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene YAF2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'YAF2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.44 | Q11 | Are there any IER5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the IER5 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs2332059
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.78e-06; HEIDI: 2.5292e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'IER5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1568895', 'Gene': 'IER5', 'topRSID': 'rs2332059', 'p_SMR_multi': 2.778497e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002529211}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.278 | Q11 | Are there any AP003041.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AP003041.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AP003041.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1096 | Q11 | Are there any MRNIP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene MRNIP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MRNIP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.104 | Q11 | Are there any LINC00959 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene LINC00959 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LINC00959' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.856 | Q11 | Are there any EI24 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene EI24 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EI24' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.985 | Q11 | Are there any CD46P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CD46P1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6659617
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.46e-06; HEIDI: 2.1086e-08 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD46P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_655849', 'Gene': 'CD46P1', 'topRSID': 'rs6659617', 'p_SMR_multi': 2.462939e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.108601e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.948 | Q11 | Are there any CLEC14A SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CLEC14A that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CLEC14A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.110 | Q11 | Are there any RNF115 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene RNF115 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RNF115' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1296 | Q11 | Are there any RPSA SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Spinalcord, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Liver and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RPSA that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RPSA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.503 | Q11 | Are there any RP3-497J21.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP3-497J21.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP3-497J21.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1981 | Q11 | Are there any TNFRSF1A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TNFRSF1A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TNFRSF1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.869 | Q11 | Are there any PDLIM7 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PDLIM7 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PDLIM7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.748 | Q11 | Are there any AC007382.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC007382.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC007382.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1015 | Q11 | Are there any SLC10A4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene SLC10A4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLC10A4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1315 | Q11 | Are there any C17orf107 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C17orf107 gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs16954243
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.80e-07; HEIDI: 8.1503e-03
• rs72835059
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.96e-07; HEIDI: 3.2654e-03
• rs140874286
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.39e-07; HEIDI: 1.2021e-02
• rs2277681
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.63e-07; HEIDI: 4.7895e-01
• rs72835064
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.36e-06; HEIDI: 1.5914e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C17orf107' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589015', 'Gene': 'C17orf107', 'topRSID': 'rs16954243', 'p_SMR_multi': 3.798115e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008150263}, {'UUID': 'NDD_SMR_genes_all_update_text_1501912', 'Gene': 'C17orf107', 'topRSID': 'rs72835059', 'p_SMR_multi': 6.961334e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00326543}, {'UUID': 'NDD_SMR_genes_all_update_text_589013', 'Gene': 'C17orf107', 'topRSID': 'rs140874286', 'p_SMR_multi': 7.394734e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0120211}, {'UUID': 'NDD_SMR_genes_all_update_text_113031', 'Gene': 'C17orf107', 'topRSID': 'rs2277681', 'p_SMR_multi': 8.626572e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4789548}, {'UUID': 'NDD_SMR_genes_all_update_text_589014', 'Gene': 'C17orf107', 'topRSID': 'rs72835064', 'p_SMR_multi': 1.361603e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01591445}, {'UUID': 'NDD_SMR_genes_all_update_text_113032', 'Gene': 'C17orf107', 'topRSID': 'rs2277681', 'p_SMR_multi': 1.499356e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4383009}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1297 | Q11 | Are there any IRX1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene IRX1P1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IRX1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.609 | Q11 | Are there any C11orf91 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene C11orf91 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C11orf91' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1362 | Q11 | Are there any DOT1L SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene DOT1L that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'DOT1L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.75 | Q11 | Are there any RNU6-1005P SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RNU6-1005P that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RNU6-1005P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1082 | Q11 | Are there any RPS29P12 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RPS29P12 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RPS29P12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1214 | Q11 | Are there any MS4A6A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MS4A6A gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7935829
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.25e-20; HEIDI: 4.2419e-03
• rs1834557
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.71e-11; HEIDI: 1.7288e-01
• rs636147
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.20e-10; HEIDI: 1.7748e-03
• rs614104
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.42e-06; HEIDI: 1.7964e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MS4A6A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498262', 'Gene': 'MS4A6A', 'topRSID': 'rs7935829', 'p_SMR_multi': 4.2520899999999996e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004241877}, {'UUID': 'NDD_SMR_genes_all_update_text_608694', 'Gene': 'MS4A6A', 'topRSID': 'rs1834557', 'p_SMR_multi': 6.713058e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1728839}, {'UUID': 'NDD_SMR_genes_all_update_text_1650729', 'Gene': 'MS4A6A', 'topRSID': 'rs636147', 'p_SMR_multi': 3.204332e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001774793}, {'UUID': 'NDD_SMR_genes_all_update_text_91391', 'Gene': 'MS4A6A', 'topRSID': 'rs614104', 'p_SMR_multi': 1.424615e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01796425}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1167 | Q11 | Are there any KHDC3L SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve and Whole Brain samples tested there are no SNPs within the gene KHDC3L that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'KHDC3L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.625 | Q11 | Are there any FAM198A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Liver and Cerebellum samples tested there are no SNPs within the gene FAM198A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM198A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.487 | Q11 | Are there any ZNF668 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ZNF668 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2303222
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.08e-08; HEIDI: 1.0508e-04
• rs4889530
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.47e-07; HEIDI: 2.3384e-09
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.74e-07; HEIDI: 1.1136e-02
• rs11647284
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.03e-07; HEIDI: 1.8271e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF668' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563812', 'Gene': 'ZNF668', 'topRSID': 'rs2303222', 'p_SMR_multi': 4.075299e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00010508}, {'UUID': 'NDD_SMR_genes_all_update_text_1435345', 'Gene': 'ZNF668', 'topRSID': 'rs4889530', 'p_SMR_multi': 1.474019e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.338424e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1679160', 'Gene': 'ZNF668', 'topRSID': 'rs4889530', 'p_SMR_multi': 1.736465e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01113564}, {'UUID': 'NDD_SMR_genes_all_update_text_974686', 'Gene': 'ZNF668', 'topRSID': 'rs11647284', 'p_SMR_multi': 3.029697e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.827066e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1579 | Q11 | Are there any TBC1D15 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene TBC1D15 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TBC1D15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.512 | Q11 | Are there any ASAP2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ASAP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ASAP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.740 | Q11 | Are there any CD46 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CD46 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CD46' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.762 | Q11 | Are there any TOB1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene TOB1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TOB1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1990 | Q11 | Are there any RP4-728D4.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP4-728D4.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP4-728D4.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.784 | Q11 | Are there any LRRC37A2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LRRC37A2 gene has 16 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2696466
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.22e-08; HEIDI: 4.8368e-02
• Cortex: Adjusted SMR multi-SNP P-value: 3.80e-08; HEIDI: 8.9926e-01
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.88e-06; HEIDI: 5.1393e-01
• rs55825513
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.35e-08; HEIDI: 2.7623e-02
• rs112560196
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.53e-08; HEIDI: 2.3872e-03
• rs2532329
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.57e-08; HEIDI: 9.4181e-01
• rs4510068
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.15e-07; HEIDI: 4.0087e-01
• rs413917
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.97e-07; HEIDI: 4.8485e-01
• rs2532233
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.41e-07; HEIDI: -9.9990e+03
• rs56971664
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 1.03e-06; HEIDI: 6.8694e-01
• rs7502718
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.16e-06; HEIDI: -9.9990e+03
• rs62062768
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.40e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LRRC37A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203020', 'Gene': 'LRRC37A2', 'topRSID': 'rs2696466', 'p_SMR_multi': 1.220094e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.04836808}, {'UUID': 'NDD_SMR_genes_all_update_text_1106833', 'Gene': 'LRRC37A2', 'topRSID': 'rs2696466', 'p_SMR_multi': 3.800326e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.8992636}, {'UUID': 'NDD_SMR_genes_all_update_text_1610873', 'Gene': 'LRRC37A2', 'topRSID': 'rs55825513', 'p_SMR_multi': 4.35167e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02762345}, {'UUID': 'NDD_SMR_genes_all_update_text_1502456', 'Gene': 'LRRC37A2', 'topRSID': 'rs112560196', 'p_SMR_multi': 4.532871e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002387193}, {'UUID': 'NDD_SMR_genes_all_update_text_1396752', 'Gene': 'LRRC37A2', 'topRSID': 'rs2532329', 'p_SMR_multi': 4.574788e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.9418131}, {'UUID': 'NDD_SMR_genes_all_update_text_1343161', 'Gene': 'LRRC37A2', 'topRSID': 'rs4510068', 'p_SMR_multi': 1.152517e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.4008675}, {'UUID': 'NDD_SMR_genes_all_update_text_1717385', 'Gene': 'LRRC37A2', 'topRSID': 'rs413917', 'p_SMR_multi': 6.966281e-07, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.484854}, {'UUID': 'NDD_SMR_genes_all_update_text_2660', 'Gene': 'LRRC37A2', 'topRSID': 'rs2532233', 'p_SMR_multi': 8.412029e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1480166', 'Gene': 'LRRC37A2', 'topRSID': 'rs56971664', 'p_SMR_multi': 1.027318e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.6869415}, {'UUID': 'NDD_SMR_genes_all_update_text_1652505', 'Gene': 'LRRC37A2', 'topRSID': 'rs7502718', 'p_SMR_multi': 1.163314e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1291768', 'Gene': 'LRRC37A2', 'topRSID': 'rs62062768', 'p_SMR_multi': 1.402024e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1157207', 'Gene': 'LRRC37A2', 'topRSID': 'rs4074462', 'p_SMR_multi': 1.497902e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.817564}, {'UUID': 'NDD_SMR_genes_all_update_text_1454364', 'Gene': 'LRRC37A2', 'topRSID': 'rs8073146', 'p_SMR_multi': 1.585859e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.4894522}, {'UUID': 'NDD_SMR_genes_all_update_text_1690053', 'Gene': 'LRRC37A2', 'topRSID': 'rs17564020', 'p_SMR_multi': 1.63534e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.8570875}, {'UUID': 'NDD_SMR_genes_all_update_text_1466652', 'Gene': 'LRRC37A2', 'topRSID': 'rs58879558', 'p_SMR_multi': 1.898336e-06, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.1531949}, {'UUID': 'NDD_SMR_genes_all_update_text_1378575', 'Gene': 'LRRC37A2', 'topRSID': 'rs2942166', 'p_SMR_multi': 2.251302e-06, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.3720312}, {'UUID': 'NDD_SMR_genes_all_update_text_1598275', 'Gene': 'LRRC37A2', 'topRSID': 'rs2942166', 'p_SMR_multi': 2.54217e-06, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.3929416}, {'UUID': 'NDD_SMR_genes_all_update_text_1584318', 'Gene': 'LRRC37A2', 'topRSID': 'rs55942528', 'p_SMR_multi': 2.716762e-06, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.7963627}, {'UUID': 'NDD_SMR_genes_all_update_text_30835', 'Gene': 'LRRC37A2', 'topRSID': 'rs2696466', 'p_SMR_multi': 2.882999e-06, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.5139333}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1763 | Q11 | Are there any SPPL2C SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SPPL2C gene has 5 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2532233
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.57e-11; HEIDI: -9.9990e+03
• rs17573607
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.34e-10; HEIDI: -9.9990e+03
• rs56023973
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.03e-10; HEIDI: -9.9990e+03
• rs55980621
• Cortex: Adjusted SMR multi-SNP P-value: 1.55e-09; HEIDI: -9.9990e+03
• rs17577369
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.30e-07; HEIDI: 1.8426e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SPPL2C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_19646', 'Gene': 'SPPL2C', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.566455e-11, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710348', 'Gene': 'SPPL2C', 'topRSID': 'rs17573607', 'p_SMR_multi': 1.339679e-10, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1191170', 'Gene': 'SPPL2C', 'topRSID': 'rs56023973', 'p_SMR_multi': 2.029874e-10, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1147254', 'Gene': 'SPPL2C', 'topRSID': 'rs55980621', 'p_SMR_multi': 1.548639e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242272', 'Gene': 'SPPL2C', 'topRSID': 'rs17577369', 'p_SMR_multi': 1.300466e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.01842581}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.848 | Q11 | Are there any CLK4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CLK4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CLK4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.315 | Q11 | Are there any KAT8 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KAT8 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4527034
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.14e-07; HEIDI: 2.1959e-07
• rs1060506
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.78e-07; HEIDI: 1.4640e-01
• rs1978487
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.55e-07; HEIDI: 6.8569e-02
• rs4889619
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.80e-07; HEIDI: 1.3215e-01
• rs1978485
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.79e-07; HEIDI: 9.0896e-03
• rs12597511
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.45e-06; HEIDI: 2.6472e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KAT8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1396181', 'Gene': 'KAT8', 'topRSID': 'rs4527034', 'p_SMR_multi': 1.137367e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.195895e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1501482', 'Gene': 'KAT8', 'topRSID': 'rs1060506', 'p_SMR_multi': 1.783298e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1463961}, {'UUID': 'NDD_SMR_genes_all_update_text_577507', 'Gene': 'KAT8', 'topRSID': 'rs1978487', 'p_SMR_multi': 2.552341e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06856892}, {'UUID': 'NDD_SMR_genes_all_update_text_109531', 'Gene': 'KAT8', 'topRSID': 'rs4889619', 'p_SMR_multi': 2.796459e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1321537}, {'UUID': 'NDD_SMR_genes_all_update_text_109533', 'Gene': 'KAT8', 'topRSID': 'rs4889619', 'p_SMR_multi': 3.017675e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0003230089}, {'UUID': 'NDD_SMR_genes_all_update_text_577509', 'Gene': 'KAT8', 'topRSID': 'rs1978485', 'p_SMR_multi': 6.786638e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009089584}, {'UUID': 'NDD_SMR_genes_all_update_text_1610408', 'Gene': 'KAT8', 'topRSID': 'rs12597511', 'p_SMR_multi': 1.448042e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2647209}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.816 | Q11 | Are there any PLEKHM1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the PLEKHM1 gene has 3 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs393152
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.31e-25; HEIDI: 1.6967e-21
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.71e-22; HEIDI: 9.3558e-09
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.54e-18; HEIDI: 1.6076e-08
• Cortex: Adjusted SMR multi-SNP P-value: 7.79e-12; HEIDI: 8.2017e-08
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 8.48e-12; HEIDI: 1.0571e-05
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.07e-09; HEIDI: 1.3745e-04
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.60e-08; HEIDI: 1.8687e-03
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 8.50e-08; HEIDI: 4.8750e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.27e-07; HEIDI: 1.1240e-03
• rs1981997
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.19e-22; HEIDI: 3.2179e-34
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.41e-20; HEIDI: 8.4232e-21
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.67e-16; HEIDI: 4.1796e-15
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PLEKHM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_22215', 'Gene': 'PLEKHM1', 'topRSID': 'rs393152', 'p_SMR_multi': 8.306359e-25, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.696664e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1579413', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 1.705019e-22, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.355808e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1444268', 'Gene': 'PLEKHM1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.18827e-22, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.217897e-34}, {'UUID': 'NDD_SMR_genes_all_update_text_1714147', 'Gene': 'PLEKHM1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.406191e-20, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 8.42317e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1375922', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 9.542938e-18, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.607626e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1194209', 'Gene': 'PLEKHM1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.671845e-16, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 4.179595e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1264976', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 7.791004e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 8.201673e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1732389', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 8.479211e-12, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.057079e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1154393', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 4.809156e-10, 'Omic_tissue': 'Cortex', 'p_HEIDI': 1.072158e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1596817', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 3.065969e-09, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.0001374477}, {'UUID': 'NDD_SMR_genes_all_update_text_1283696', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 2.601381e-08, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.001868686}, {'UUID': 'NDD_SMR_genes_all_update_text_1489532', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 8.497756e-08, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.487497}, {'UUID': 'NDD_SMR_genes_all_update_text_1170868', 'Gene': 'PLEKHM1', 'topRSID': 'rs11012', 'p_SMR_multi': 2.267121e-07, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.001124046}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.411 | Q11 | Are there any RP11-455F5.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-455F5.3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7205802
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.05e-08; HEIDI: 3.8110e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-455F5.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501445', 'Gene': 'RP11-455F5.3', 'topRSID': 'rs7205802', 'p_SMR_multi': 2.050543e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03811032}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.826 | Q11 | Are there any OR8A1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene OR8A1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'OR8A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1143 | Q11 | Are there any ZNF846 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene ZNF846 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZNF846' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.313 | Q11 | Are there any PCDH1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PCDH1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PCDH1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.229 | Q11 | Are there any AC110619.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC110619.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC110619.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1699 | Q11 | Are there any PDE6G SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene PDE6G that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PDE6G' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1451 | Q11 | Are there any N4BP2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene N4BP2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'N4BP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1976 | Q11 | Are there any VASP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the VASP gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7252959
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.47e-07; HEIDI: 1.2603e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'VASP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503927', 'Gene': 'VASP', 'topRSID': 'rs7252959', 'p_SMR_multi': 4.468401e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001260265}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.814 | Q11 | Are there any GPR110 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GPR110 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GPR110' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1847 | Q11 | Are there any WBP2NL SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene WBP2NL that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'WBP2NL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.151 | Q11 | Are there any TTC23L SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TTC23L that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TTC23L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.781 | Q11 | Are there any KAT8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the KAT8 gene has 12 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs1060506
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.91e-09; HEIDI: 9.0299e-05
• Cortex: Adjusted SMR multi-SNP P-value: 6.68e-07; HEIDI: 3.8289e-02
• rs4527034
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.02e-08; HEIDI: 1.0643e-10
• rs1978487
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.53e-08; HEIDI: 7.3158e-03
• rs9936329
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.76e-08; HEIDI: 6.9711e-02
• rs1978485
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.88e-08; HEIDI: 2.5086e-03
• rs9972727
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 8.64e-08; HEIDI: 3.5024e-03
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.04e-06; HEIDI: 1.2644e-02
• rs9925964
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.57e-07; HEIDI: 5.3875e-02
• rs2855475
• Cortex: Adjusted SMR multi-SNP P-value: 1.65e-07; HEIDI: 9.1701e-03
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 3.28e-07; HEIDI: 2.5232e-02
• rs12597511
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.84e-07; HEIDI: 4.5863e-02
• rs1549293
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.21e-06; HEIDI: 4.1075e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KAT8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563818', 'Gene': 'KAT8', 'topRSID': 'rs1060506', 'p_SMR_multi': 2.914295e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.02986e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1435348', 'Gene': 'KAT8', 'topRSID': 'rs4527034', 'p_SMR_multi': 1.024732e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.064305e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_974691', 'Gene': 'KAT8', 'topRSID': 'rs1978487', 'p_SMR_multi': 1.533291e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007315752}, {'UUID': 'NDD_SMR_genes_all_update_text_1328410', 'Gene': 'KAT8', 'topRSID': 'rs9936329', 'p_SMR_multi': 3.760457e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.06971106}, {'UUID': 'NDD_SMR_genes_all_update_text_974693', 'Gene': 'KAT8', 'topRSID': 'rs1978485', 'p_SMR_multi': 7.880096e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002508634}, {'UUID': 'NDD_SMR_genes_all_update_text_1241727', 'Gene': 'KAT8', 'topRSID': 'rs9972727', 'p_SMR_multi': 8.642794e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.003502415}, {'UUID': 'NDD_SMR_genes_all_update_text_1370183', 'Gene': 'KAT8', 'topRSID': 'rs9925964', 'p_SMR_multi': 1.565722e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0538749}, {'UUID': 'NDD_SMR_genes_all_update_text_1140854', 'Gene': 'KAT8', 'topRSID': 'rs2855475', 'p_SMR_multi': 1.654424e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.009170133}, {'UUID': 'NDD_SMR_genes_all_update_text_1639764', 'Gene': 'KAT8', 'topRSID': 'rs12597511', 'p_SMR_multi': 1.841304e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04586272}, {'UUID': 'NDD_SMR_genes_all_update_text_1190939', 'Gene': 'KAT8', 'topRSID': 'rs2855475', 'p_SMR_multi': 3.278791e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.02523191}, {'UUID': 'NDD_SMR_genes_all_update_text_1262000', 'Gene': 'KAT8', 'topRSID': 'rs1060506', 'p_SMR_multi': 6.677719e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.03828886}, {'UUID': 'NDD_SMR_genes_all_update_text_1710060', 'Gene': 'KAT8', 'topRSID': 'rs9972727', 'p_SMR_multi': 1.039952e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.01264411}, {'UUID': 'NDD_SMR_genes_all_update_text_20691', 'Gene': 'KAT8', 'topRSID': 'rs1549293', 'p_SMR_multi': 1.206698e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.04107506}, {'UUID': 'NDD_SMR_genes_all_update_text_1462783', 'Gene': 'KAT8', 'topRSID': 'rs61162043', 'p_SMR_multi': 1.814967e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.2130376}, {'UUID': 'NDD_SMR_genes_all_update_text_485466', 'Gene': 'KAT8', 'topRSID': 'rs4889619', 'p_SMR_multi': 2.531462e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.5369356}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.727 | Q11 | Are there any APOC1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the APOC1 gene has 3 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs10414043
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.53e-08; HEIDI: 1.0373e-03
• rs4803770
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.02e-07; HEIDI: 2.5992e-04
• rs59325138
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-06; HEIDI: 1.8021e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'APOC1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_402975', 'Gene': 'APOC1', 'topRSID': 'rs10414043', 'p_SMR_multi': 5.527557e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001037341}, {'UUID': 'NDD_SMR_genes_all_update_text_1426981', 'Gene': 'APOC1', 'topRSID': 'rs4803770', 'p_SMR_multi': 3.01602e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.0002599168}, {'UUID': 'NDD_SMR_genes_all_update_text_928300', 'Gene': 'APOC1', 'topRSID': 'rs59325138', 'p_SMR_multi': 1.122469e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01802146}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.820 | Q11 | Are there any RP11-65E22.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene RP11-65E22.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-65E22.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1636 | Q11 | Are there any NFATC4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene NFATC4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'NFATC4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.825 | Q11 | Are there any GASK1B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene GASK1B that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GASK1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.581 | Q11 | Are there any RP11-400N13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-400N13.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-400N13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.563 | Q11 | Are there any ZNF503-AS2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood, Cerebellar Hemisphere and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZNF503-AS2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZNF503-AS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1758 | Q11 | Are there any CCT5P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CCT5P1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CCT5P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1727 | Q11 | Are there any OR2A9P SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene OR2A9P that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'OR2A9P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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