uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.1349 | Q11 | Are there any AC008440.10 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC008440.10 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC008440.10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1161 | Q11 | Are there any ZNF436 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene ZNF436 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF436' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.945 | Q11 | Are there any RP11-65D24.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-65D24.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-65D24.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.290 | Q11 | Are there any BCL3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the BCL3 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62117204
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.18e-12; HEIDI: 3.0388e-06
• rs8100197
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.52e-09; HEIDI: 7.1885e-11
• rs17658713
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.79e-09; HEIDI: 3.0141e-10
• rs1531517
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.98e-07; HEIDI: 1.5550e-07
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BCL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122454', 'Gene': 'BCL3', 'topRSID': 'rs62117204', 'p_SMR_multi': 2.17823e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.038828e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_637414', 'Gene': 'BCL3', 'topRSID': 'rs8100197', 'p_SMR_multi': 1.52421e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.18848e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_122453', 'Gene': 'BCL3', 'topRSID': 'rs17658713', 'p_SMR_multi': 2.794616e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.014149e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1503904', 'Gene': 'BCL3', 'topRSID': 'rs1531517', 'p_SMR_multi': 2.981436e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.554987e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1947 | Q11 | Are there any RN7SL656P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RN7SL656P gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs199447
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.31e-07; HEIDI: 2.4007e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RN7SL656P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203017', 'Gene': 'RN7SL656P', 'topRSID': 'rs199447', 'p_SMR_multi': 7.310742e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0240069}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.973 | Q11 | Are there any LINC01137 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LINC01137 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LINC01137' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.605 | Q11 | Are there any HNRNPA1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene HNRNPA1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HNRNPA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1312 | Q11 | Are there any CTC-459F4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CTC-459F4.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTC-459F4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1244 | Q11 | Are there any RP11-366M4.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-366M4.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-366M4.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1638 | Q11 | Are there any RN7SL199P SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RN7SL199P gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs2950694
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 4.16e-10; HEIDI: 2.4462e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RN7SL199P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242286', 'Gene': 'RN7SL199P', 'topRSID': 'rs2950694', 'p_SMR_multi': 4.158155e-10, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002446177}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1588 | Q11 | Are there any OR2T4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene OR2T4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'OR2T4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1316 | Q11 | Are there any RN7SL282P SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RN7SL282P that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RN7SL282P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1779 | Q11 | Are there any BOK SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene BOK that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'BOK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1647 | Q11 | Are there any CDH8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CDH8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CDH8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1255 | Q11 | Are there any ZNF192P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF192P1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1654774
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.08e-06; HEIDI: 4.5388e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF192P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494669', 'Gene': 'ZNF192P1', 'topRSID': 'rs1654774', 'p_SMR_multi': 1.078987e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04538779}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1675 | Q11 | Are there any G2E3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | Yes, the G2E3 gene has 1 SNP that is statistically significant in Amyotrophic Lateral Sclerosis:
• rs2295425
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.58e-06; HEIDI: 1.4524e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'G2E3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1515763', 'Gene': 'G2E3', 'topRSID': 'rs2295425', 'p_SMR_multi': 2.577425e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0145237}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1801 | Q11 | Are there any RP11-554D14.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-554D14.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-554D14.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.759 | Q11 | Are there any CCDC137 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CCDC137 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CCDC137' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.616 | Q11 | Are there any PRKCDBP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene PRKCDBP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PRKCDBP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1045 | Q11 | Are there any PTGES SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene PTGES that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PTGES' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.788 | Q11 | Are there any SOCS5P1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene SOCS5P1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SOCS5P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1690 | Q11 | Are there any AC091132.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the AC091132.1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs1724400
• Cerebellum: Adjusted SMR multi-SNP P-value: 6.17e-08; HEIDI: 1.1660e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC091132.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1710341', 'Gene': 'AC091132.1', 'topRSID': 'rs1724400', 'p_SMR_multi': 6.167256e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.116595}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.997 | Q11 | Are there any NTN1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene NTN1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NTN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.499 | Q11 | Are there any SPOCK1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SPOCK1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SPOCK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1320 | Q11 | Are there any TPD52L3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TPD52L3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TPD52L3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.281 | Q11 | Are there any AC123768.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene AC123768.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC123768.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1848 | Q11 | Are there any MAP10 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MAP10 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MAP10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.363 | Q11 | Are there any APOC1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the APOC1P1 gene has 2 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs59325138
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.21e-10; HEIDI: 3.5636e-19
• rs157595
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.02e-07; HEIDI: 1.5734e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'APOC1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_928302', 'Gene': 'APOC1P1', 'topRSID': 'rs59325138', 'p_SMR_multi': 5.210558e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.5635789999999995e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_402976', 'Gene': 'APOC1P1', 'topRSID': 'rs157595', 'p_SMR_multi': 4.017664e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.573378e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1179 | Q11 | Are there any GPNMB SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the GPNMB gene has 11 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs858275
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.08e-08; HEIDI: 1.0464e-02
• rs199348
• Cortex: Adjusted SMR multi-SNP P-value: 1.61e-08; HEIDI: 4.3616e-01
• rs199357
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.88e-08; HEIDI: 5.2842e-01
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.89e-08; HEIDI: 2.3942e-02
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 8.08e-07; HEIDI: 1.0048e-01
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 9.66e-07; HEIDI: 3.5486e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.20e-06; HEIDI: 2.0057e-01
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.20e-06; HEIDI: 1.3510e-01
• rs858239
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.94e-08; HEIDI: 2.8885e-01
• rs466240
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.84e-08; HEIDI: 1.1991e-02
• rs858274
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.21e-08; HEIDI: 9.3044e-01
• rs466225
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.06e-08; HEIDI: 2.1428e-04
• rs1637190
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.00e-07; HEIDI: 4.8338e-01
• rs858273
• Cortex: Adjusted SMR multi-SNP P-value: 1.40e-06; HEIDI: 3.0257e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 2.65e-06; HEIDI: 3.4658e-01
• rs199355
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.94e-06; HEIDI: 9.9601e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GPNMB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1431548', 'Gene': 'GPNMB', 'topRSID': 'rs858275', 'p_SMR_multi': 1.080397e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.01046363}, {'UUID': 'NDD_SMR_genes_all_update_text_1146423', 'Gene': 'GPNMB', 'topRSID': 'rs199348', 'p_SMR_multi': 1.607416e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.4361632}, {'UUID': 'NDD_SMR_genes_all_update_text_1237816', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 1.883068e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.5284207}, {'UUID': 'NDD_SMR_genes_all_update_text_447897', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 1.890519e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02394197}, {'UUID': 'NDD_SMR_genes_all_update_text_1557764', 'Gene': 'GPNMB', 'topRSID': 'rs858239', 'p_SMR_multi': 1.937936e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2888536}, {'UUID': 'NDD_SMR_genes_all_update_text_447896', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 2.451637e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02003686}, {'UUID': 'NDD_SMR_genes_all_update_text_447898', 'Gene': 'GPNMB', 'topRSID': 'rs466240', 'p_SMR_multi': 2.842165e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01199117}, {'UUID': 'NDD_SMR_genes_all_update_text_1636966', 'Gene': 'GPNMB', 'topRSID': 'rs858274', 'p_SMR_multi': 3.210543e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.9304421}, {'UUID': 'NDD_SMR_genes_all_update_text_447894', 'Gene': 'GPNMB', 'topRSID': 'rs466225', 'p_SMR_multi': 5.064964e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0002142825}, {'UUID': 'NDD_SMR_genes_all_update_text_447895', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 1.386696e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0004659306}, {'UUID': 'NDD_SMR_genes_all_update_text_20283', 'Gene': 'GPNMB', 'topRSID': 'rs1637190', 'p_SMR_multi': 2.001395e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.4833769}, {'UUID': 'NDD_SMR_genes_all_update_text_447900', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 2.461938e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2766202}, {'UUID': 'NDD_SMR_genes_all_update_text_447899', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 5.789874e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.8757561}, {'UUID': 'NDD_SMR_genes_all_update_text_1728685', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 8.078376e-07, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.1004834}, {'UUID': 'NDD_SMR_genes_all_update_text_1593746', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 9.655041e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.3548551}, {'UUID': 'NDD_SMR_genes_all_update_text_1167543', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 1.201065e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.20057}, {'UUID': 'NDD_SMR_genes_all_update_text_1260547', 'Gene': 'GPNMB', 'topRSID': 'rs858273', 'p_SMR_multi': 1.397219e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.3025674}, {'UUID': 'NDD_SMR_genes_all_update_text_447901', 'Gene': 'GPNMB', 'topRSID': 'rs199355', 'p_SMR_multi': 1.938068e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.09960067}, {'UUID': 'NDD_SMR_genes_all_update_text_1487264', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_SMR_multi': 2.196425e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.1350986}, {'UUID': 'NDD_SMR_genes_all_update_text_1461950', 'Gene': 'GPNMB', 'topRSID': 'rs858273', 'p_SMR_multi': 2.651864e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.3465819}, {'UUID': 'NDD_SMR_genes_all_update_text_1279901', 'Gene': 'GPNMB', 'topRSID': 'rs199351', 'p_SMR_multi': 2.88348e-06, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.1075492}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.239 | Q11 | Are there any FCER1G SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FCER1G gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2070901
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.26e-09; HEIDI: 2.7542e-02
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 5.45e-07; HEIDI: 6.9820e-01
• rs4379692
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.89e-07; HEIDI: 5.9834e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FCER1G' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1490908', 'Gene': 'FCER1G', 'topRSID': 'rs2070901', 'p_SMR_multi': 2.258228e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02754168}, {'UUID': 'NDD_SMR_genes_all_update_text_1389452', 'Gene': 'FCER1G', 'topRSID': 'rs4379692', 'p_SMR_multi': 2.894472e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.005983408}, {'UUID': 'NDD_SMR_genes_all_update_text_1337987', 'Gene': 'FCER1G', 'topRSID': 'rs2070901', 'p_SMR_multi': 5.453774e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.6982046}, {'UUID': 'NDD_SMR_genes_all_update_text_1647531', 'Gene': 'FCER1G', 'topRSID': 'rs2070901', 'p_SMR_multi': 1.125342e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08890531}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.557 | Q11 | Are there any LHX5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene LHX5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LHX5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1870 | Q11 | Are there any FAM215B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the FAM215B gene has 4 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.76e-17; HEIDI: 3.3599e-07
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.73e-12; HEIDI: 3.6995e-05
• rs169201
• Cerebellum: Adjusted SMR multi-SNP P-value: 6.81e-16; HEIDI: 4.6023e-07
• rs415430
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 3.10e-12; HEIDI: 1.4397e-03
• rs11012
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.49e-07; HEIDI: 1.4103e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FAM215B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579431', 'Gene': 'FAM215B', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.7603150000000002e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.359908e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1714165', 'Gene': 'FAM215B', 'topRSID': 'rs169201', 'p_SMR_multi': 6.809593e-16, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 4.602325e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1336300', 'Gene': 'FAM215B', 'topRSID': 'rs17692129', 'p_SMR_multi': 2.733178e-12, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 3.699536e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1194225', 'Gene': 'FAM215B', 'topRSID': 'rs415430', 'p_SMR_multi': 3.098706e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.001439668}, {'UUID': 'NDD_SMR_genes_all_update_text_1646052', 'Gene': 'FAM215B', 'topRSID': 'rs11012', 'p_SMR_multi': 2.487877e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.410288e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1915 | Q11 | Are there any RP11-977G19.11 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-977G19.11 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-977G19.11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.211 | Q11 | Are there any RP11-259G18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-259G18.3 gene has 12 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs199439
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.19e-16; HEIDI: 4.6759e-07
• rs62060793
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.54e-15; HEIDI: -9.9990e+03
• rs2732615
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.42e-14; HEIDI: 1.0732e-03
• rs169201
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.82e-14; HEIDI: -9.9990e+03
• rs199456
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 4.23e-14; HEIDI: -9.9990e+03
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.38e-11; HEIDI: 5.8770e-03
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.67e-11; HEIDI: 2.0829e-03
• rs9468
• Liver: Adjusted SMR multi-SNP P-value: 7.61e-13; HEIDI: -9.9990e+03
• rs55974014
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.39e-12; HEIDI: 2.2080e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.05e-12; HEIDI: 3.1792e-01
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 6.75e-12; HEIDI: 1.6448e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.15e-11; HEIDI: 3.4628e-01
• Amygdala: Adjusted SMR multi-SNP P-value: 8.59e-11; HEIDI: 5.7129e-01
• rs55942528
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.45e-12; HEIDI: -9.9990e+03
• rs199533
• Cortex: Adjusted SMR multi-SNP P-value: 1.46e-12; HEIDI: 5.2439e-02
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.88e-11; HEIDI: 3.3712e-05
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.05e-11; HEIDI: 5.2204e-03
• Substantia nigra: Adjusted SMR multi-SNP P-value: 1.46e-08; HEIDI: 2.0097e-03
• rs561504284
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.16e-12; HEIDI: 2.4515e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-259G18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564787', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199439', 'p_SMR_multi': 5.193095e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.675871e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1679568', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs62060793', 'p_SMR_multi': 7.539759e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242279', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs2732615', 'p_SMR_multi': 1.418251e-14, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.001073235}, {'UUID': 'NDD_SMR_genes_all_update_text_1370547', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 1.818091e-14, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1328936', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199456', 'p_SMR_multi': 4.22626e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1476429', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs9468', 'p_SMR_multi': 7.605082e-13, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1281357', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.387203e-12, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.2207953}, {'UUID': 'NDD_SMR_genes_all_update_text_1710352', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55942528', 'p_SMR_multi': 1.449789e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262227', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 1.45849e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.05243878}, {'UUID': 'NDD_SMR_genes_all_update_text_1730067', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.046569e-12, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.3179196}, {'UUID': 'NDD_SMR_genes_all_update_text_491157', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs561504284', 'p_SMR_multi': 2.158457e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2451459}, {'UUID': 'NDD_SMR_genes_all_update_text_1191174', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 6.749073e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.1644817}, {'UUID': 'NDD_SMR_genes_all_update_text_1594926', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs62061822', 'p_SMR_multi': 9.554985e-12, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1462897', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.146115e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.346278}, {'UUID': 'NDD_SMR_genes_all_update_text_1640224', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 1.878182e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.37117e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1488142', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 2.054214e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.005220416}, {'UUID': 'NDD_SMR_genes_all_update_text_1168837', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199456', 'p_SMR_multi': 2.377632e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.005877049}, {'UUID': 'NDD_SMR_genes_all_update_text_1386993', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199456', 'p_SMR_multi': 3.66762e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.002082923}, {'UUID': 'NDD_SMR_genes_all_update_text_1603778', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 8.594983e-11, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.5712904}, {'UUID': 'NDD_SMR_genes_all_update_text_491158', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs566979023', 'p_SMR_multi': 2.24008e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1704128}, {'UUID': 'NDD_SMR_genes_all_update_text_1451665', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 1.463079e-08, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.002009684}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1922 | Q11 | Are there any AC135048.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the AC135048.1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs7199949
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.21e-08; HEIDI: 5.0101e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC135048.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_485448', 'Gene': 'AC135048.1', 'topRSID': 'rs7199949', 'p_SMR_multi': 3.211323e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0005010102}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1561 | Q11 | Are there any NSFP1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NSFP1 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17698176
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.33e-10; HEIDI: 5.1182e-11
• rs151267673
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.31e-07; HEIDI: 2.7194e-10
• rs3874943
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.81e-06; HEIDI: 2.5459e-11
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NSFP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564791', 'Gene': 'NSFP1', 'topRSID': 'rs17698176', 'p_SMR_multi': 9.333059e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.118198e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1242284', 'Gene': 'NSFP1', 'topRSID': 'rs151267673', 'p_SMR_multi': 7.311026e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 2.719373e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1370551', 'Gene': 'NSFP1', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.814056e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 2.545892e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1679571', 'Gene': 'NSFP1', 'topRSID': 'rs17698176', 'p_SMR_multi': 2.329764e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.842467e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.60 | Q11 | Are there any PELO SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PELO that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PELO' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1835 | Q11 | Are there any RP11-151D14.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Liver samples tested there are no SNPs within the gene RP11-151D14.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-151D14.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1906 | Q11 | Are there any RP11-807H7.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-807H7.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-807H7.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1578 | Q11 | Are there any PLCZ1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PLCZ1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PLCZ1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.368 | Q11 | Are there any AC002463.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC002463.3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC002463.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.511 | Q11 | Are there any ERI1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ERI1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ERI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.815 | Q11 | Are there any SIX3-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Caudate Basal Ganglia samples tested there are no SNPs within the gene SIX3-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SIX3-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1122 | Q11 | Are there any C9orf139 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve and Putamen Basal Ganglia samples tested there are no SNPs within the gene C9orf139 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C9orf139' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1731 | Q11 | Are there any SRP9 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SRP9 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SRP9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1216 | Q11 | Are there any OR6M1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OR6M1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OR6M1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1212 | Q11 | Are there any TRBV19 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV19 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TRBV19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.971 | Q11 | Are there any ATP5A1P3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene ATP5A1P3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ATP5A1P3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.805 | Q11 | Are there any TTYH3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TTYH3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TTYH3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.121 | Q11 | Are there any PKD1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene PKD1P1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PKD1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1322 | Q11 | Are there any AC091729.7 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene AC091729.7 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC091729.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1221 | Q11 | Are there any SNCA SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SNCA gene has 9 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2245801
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.76e-14; HEIDI: 5.9744e-15
• rs2301134
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.48e-12; HEIDI: 1.8302e-18
• rs3756059
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.65e-12; HEIDI: 9.4294e-19
• rs1372520
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.94e-11; HEIDI: 9.7058e-11
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.14e-09; HEIDI: 1.4009e-12
• rs1372518
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.42e-10; HEIDI: 3.9316e-05
• rs6817026
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.92e-10; HEIDI: 3.7525e-09
• rs990085
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.30e-07; HEIDI: 4.0932e-06
• rs2736989
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.75e-06; HEIDI: 9.0260e-05
• rs5019538
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.27e-06; HEIDI: 1.0153e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SNCA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555943', 'Gene': 'SNCA', 'topRSID': 'rs2245801', 'p_SMR_multi': 9.761195e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.974436e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_998609', 'Gene': 'SNCA', 'topRSID': 'rs2301134', 'p_SMR_multi': 1.478211e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.830236e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_432414', 'Gene': 'SNCA', 'topRSID': 'rs3756059', 'p_SMR_multi': 2.653319e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 9.429443e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_432418', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 6.939231e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 9.705839e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_432417', 'Gene': 'SNCA', 'topRSID': 'rs1372518', 'p_SMR_multi': 1.422892e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.931564e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_432416', 'Gene': 'SNCA', 'topRSID': 'rs6817026', 'p_SMR_multi': 1.918689e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.752528e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_432415', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 1.666125e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.424932e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_998611', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 5.135645e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.40089e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_998610', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 2.970489e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.396822e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_998613', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 4.734834e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.413467e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_998612', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 1.537224e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.645808e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_432419', 'Gene': 'SNCA', 'topRSID': 'rs990085', 'p_SMR_multi': 2.30065e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.09319e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_998614', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 6.049353e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.689904e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1675742', 'Gene': 'SNCA', 'topRSID': 'rs2736989', 'p_SMR_multi': 1.746399e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.025993e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_19152', 'Gene': 'SNCA', 'topRSID': 'rs5019538', 'p_SMR_multi': 2.26509e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.015316e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.528 | Q11 | Are there any GNB1L SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24 and Nucleus Accumbens Basal samples tested there are no SNPs within the gene GNB1L that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GNB1L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.519 | Q11 | Are there any RP11-259G18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-259G18.1 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.33e-07; HEIDI: 1.3860e-01
• rs2532343
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.83e-06; HEIDI: 8.4290e-01
• rs62057147
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.13e-06; HEIDI: 6.5929e-01
• rs62073157
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.16e-06; HEIDI: 4.2367e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-259G18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1502452', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.328465e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1385957}, {'UUID': 'NDD_SMR_genes_all_update_text_1690049', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs2532343', 'p_SMR_multi': 1.831093e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.8429009}, {'UUID': 'NDD_SMR_genes_all_update_text_1717381', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62057147', 'p_SMR_multi': 2.130692e-06, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.659288}, {'UUID': 'NDD_SMR_genes_all_update_text_115229', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62073157', 'p_SMR_multi': 2.162918e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4236703}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.84 | Q11 | Are there any RP11-707O23.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-707O23.5 gene has 11 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2732615
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.43e-16; HEIDI: 1.6379e-04
• rs440778
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.37e-16; HEIDI: -9.9990e+03
• rs55974014
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.12e-15; HEIDI: -9.9990e+03
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.14e-15; HEIDI: 1.0447e-01
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 6.86e-15; HEIDI: -9.9990e+03
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.11e-12; HEIDI: 9.0061e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.27e-11; HEIDI: 8.5301e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.64e-11; HEIDI: 8.9536e-01
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.69e-11; HEIDI: 8.8068e-01
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 3.08e-11; HEIDI: 6.6119e-01
• Substantia nigra: Adjusted SMR multi-SNP P-value: 2.57e-08; HEIDI: 9.3595e-01
• rs9468
• Liver: Adjusted SMR multi-SNP P-value: 1.44e-12; HEIDI: -9.9990e+03
• Hippocampus: Adjusted SMR multi-SNP P-value: 6.31e-11; HEIDI: -9.9990e+03
• rs17575507
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.95e-12; HEIDI: 3.7536e-02
• rs62056812
• Cortex: Adjusted SMR multi-SNP P-value: 9.06e-12; HEIDI: -9.9990e+03
• rs2942166
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.44e-11; HEIDI: 2.2075e-01
• rs56082319
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.30e-11; HEIDI: 7.2369e-01
• rs8073146
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 4.06e-11; HEIDI: -9.9990e+03
• rs56100013
• Amygdala: Adjusted SMR multi-SNP P-value: 1.29e-10; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-707O23.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242267', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs2732615', 'p_SMR_multi': 3.426591e-16, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0001637904}, {'UUID': 'NDD_SMR_genes_all_update_text_491083', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs440778', 'p_SMR_multi': 9.366102e-16, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1370541', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.118686e-15, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1679563', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.139585e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.104475}, {'UUID': 'NDD_SMR_genes_all_update_text_1328928', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 6.856036e-15, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710346', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.110527e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.9006067}, {'UUID': 'NDD_SMR_genes_all_update_text_1476424', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs9468', 'p_SMR_multi': 1.442149e-12, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640218', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs17575507', 'p_SMR_multi': 2.948314e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.03753608}, {'UUID': 'NDD_SMR_genes_all_update_text_491082', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs440778', 'p_SMR_multi': 6.018701e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262222', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs62056812', 'p_SMR_multi': 9.060804e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1462891', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.274776e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.8530115}, {'UUID': 'NDD_SMR_genes_all_update_text_1730061', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs2942166', 'p_SMR_multi': 1.439705e-11, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.2207518}, {'UUID': 'NDD_SMR_genes_all_update_text_1168833', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.637224e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.8953624}, {'UUID': 'NDD_SMR_genes_all_update_text_1281351', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.691174e-11, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.8806778}, {'UUID': 'NDD_SMR_genes_all_update_text_1488137', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 3.07786e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.6611938}, {'UUID': 'NDD_SMR_genes_all_update_text_1594921', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs56082319', 'p_SMR_multi': 3.303079e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.7236853}, {'UUID': 'NDD_SMR_genes_all_update_text_1191168', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs8073146', 'p_SMR_multi': 4.057024e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1386989', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs9468', 'p_SMR_multi': 6.313647e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1603774', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs56100013', 'p_SMR_multi': 1.28714e-10, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1564781', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs2532233', 'p_SMR_multi': 3.988953e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02790569}, {'UUID': 'NDD_SMR_genes_all_update_text_1451661', 'Gene': 'RP11-707O23.5', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.567092e-08, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.9359494}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.717 | Q11 | Are there any C8orf49 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C8orf49 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C8orf49' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1185 | Q11 | Are there any RP11-542C16.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-542C16.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-542C16.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.386 | Q11 | Are there any HVCN1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HVCN1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HVCN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1022 | Q11 | Are there any RP11-227H15.4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere and Anterior Cingulate Cortex BA24 samples tested there are no SNPs within the gene RP11-227H15.4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-227H15.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1689 | Q11 | Are there any RP11-798G7.7 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-798G7.7 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs2732615
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.07e-12; HEIDI: 2.8804e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-798G7.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242265', 'Gene': 'RP11-798G7.7', 'topRSID': 'rs2732615', 'p_SMR_multi': 3.069222e-12, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002880433}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.87 | Q11 | Are there any RP11-115L11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-115L11.1 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4698119
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.19e-13; HEIDI: 8.9855e-02
• rs4342183
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.41e-07; HEIDI: 4.2761e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-115L11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555731', 'Gene': 'RP11-115L11.1', 'topRSID': 'rs4698119', 'p_SMR_multi': 9.188732e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0898545}, {'UUID': 'NDD_SMR_genes_all_update_text_1323417', 'Gene': 'RP11-115L11.1', 'topRSID': 'rs4342183', 'p_SMR_multi': 3.411872e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.427607}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1684 | Q11 | Are there any TTLL13P SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene TTLL13P that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TTLL13P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.333 | Q11 | Are there any NFYA SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the NFYA gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs72856298
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.34e-10; HEIDI: 1.1240e-10
• rs62396353
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.60e-10; HEIDI: 2.8307e-11
• rs11964892
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.00e-09; HEIDI: 5.6714e-10
• rs7775972
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.85e-08; HEIDI: 2.0111e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NFYA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622639', 'Gene': 'NFYA', 'topRSID': 'rs72856298', 'p_SMR_multi': 3.336665e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.123977e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_622641', 'Gene': 'NFYA', 'topRSID': 'rs72856298', 'p_SMR_multi': 5.531627e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.741809e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_622638', 'Gene': 'NFYA', 'topRSID': 'rs62396353', 'p_SMR_multi': 5.598544e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.830658e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_622640', 'Gene': 'NFYA', 'topRSID': 'rs72856298', 'p_SMR_multi': 5.625043e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.559851e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_622636', 'Gene': 'NFYA', 'topRSID': 'rs62396353', 'p_SMR_multi': 5.922928e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.057136e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_622637', 'Gene': 'NFYA', 'topRSID': 'rs62396353', 'p_SMR_multi': 7.079971e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.865121e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_622642', 'Gene': 'NFYA', 'topRSID': 'rs62396353', 'p_SMR_multi': 7.795234e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.961581e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1494866', 'Gene': 'NFYA', 'topRSID': 'rs11964892', 'p_SMR_multi': 4.000049e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.671352e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_622633', 'Gene': 'NFYA', 'topRSID': 'rs7775972', 'p_SMR_multi': 3.84677e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.011058e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.7 | Q11 | Are there any SESN3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SESN3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SESN3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.737 | Q11 | Are there any CCDC26 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CCDC26 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CCDC26' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.750 | Q11 | Are there any PROCR SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested there are no SNPs within the gene PROCR that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PROCR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1414 | Q11 | Are there any FBXO24 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene FBXO24 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FBXO24' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1751 | Q11 | Are there any MGC57346 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the MGC57346 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.68e-21; HEIDI: 4.4864e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MGC57346' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041718', 'Gene': 'MGC57346', 'topRSID': 'rs169201', 'p_SMR_multi': 5.68239e-21, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.486385e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.457 | Q11 | Are there any AC016999.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AC016999.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC016999.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.496 | Q11 | Are there any PATE2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene PATE2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PATE2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1482 | Q11 | Are there any RAD21 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene RAD21 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAD21' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.291 | Q11 | Are there any HIST1H2APS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HIST1H2APS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HIST1H2APS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1817 | Q11 | Are there any OARD1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the OARD1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4714423
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.88e-08; HEIDI: 7.3378e-04
• rs9394755
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.27e-07; HEIDI: 2.9516e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OARD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622631', 'Gene': 'OARD1', 'topRSID': 'rs4714423', 'p_SMR_multi': 7.881563e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007337849}, {'UUID': 'NDD_SMR_genes_all_update_text_622630', 'Gene': 'OARD1', 'topRSID': 'rs9394755', 'p_SMR_multi': 4.272263e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002951633}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1986 | Q11 | Are there any LGALS12 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LGALS12 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LGALS12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1370 | Q11 | Are there any PRICKLE1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PRICKLE1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRICKLE1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.893 | Q11 | Are there any RP11-262I2.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-262I2.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-262I2.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1063 | Q11 | Are there any MXRA8 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MXRA8 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MXRA8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1846 | Q11 | Are there any SDR42E2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene SDR42E2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SDR42E2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1982 | Q11 | Are there any CALR3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CALR3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CALR3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.789 | Q11 | Are there any TSC22D4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TSC22D4 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs67163493
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.75e-11; HEIDI: 6.8342e-04
• rs3807471
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.43e-08; HEIDI: 2.4771e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TSC22D4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_586004', 'Gene': 'TSC22D4', 'topRSID': 'rs67163493', 'p_SMR_multi': 5.747145e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0006834187}, {'UUID': 'NDD_SMR_genes_all_update_text_1495812', 'Gene': 'TSC22D4', 'topRSID': 'rs3807471', 'p_SMR_multi': 2.429445e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002477143}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.866 | Q11 | Are there any PEX3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PEX3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PEX3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1306 | Q11 | Are there any RP11-169K16.4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-169K16.4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-169K16.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1088 | Q11 | Are there any IDUA SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the IDUA gene has 2 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs6599388
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.81e-06; HEIDI: 8.4105e-02
• rs13137144
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.89e-06; HEIDI: 4.3871e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'IDUA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_336364', 'Gene': 'IDUA', 'topRSID': 'rs6599388', 'p_SMR_multi': 2.807229e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.08410463}, {'UUID': 'NDD_SMR_genes_all_update_text_336365', 'Gene': 'IDUA', 'topRSID': 'rs13137144', 'p_SMR_multi': 2.889122e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0004387127}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1889 | Q11 | Are there any RPS26P8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RPS26P8 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55974014
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.55e-13; HEIDI: -9.9990e+03
• rs566238830
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.16e-12; HEIDI: 4.2432e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RPS26P8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1328929', 'Gene': 'RPS26P8', 'topRSID': 'rs55974014', 'p_SMR_multi': 3.554859e-13, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242268', 'Gene': 'RPS26P8', 'topRSID': 'rs566238830', 'p_SMR_multi': 3.161049e-12, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.004243232}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.331 | Q11 | Are there any CDH1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested there are no SNPs within the gene CDH1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CDH1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.448 | Q11 | Are there any TRBV1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRBV1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.766 | Q11 | Are there any PVRL2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the PVRL2 gene has 3 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs17561351
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.64e-25; HEIDI: 2.1724e-14
• rs4452060
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 3.96e-07; HEIDI: 5.2287e-04
• rs60389450
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.56e-06; HEIDI: 1.3380e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PVRL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1550598', 'Gene': 'PVRL2', 'topRSID': 'rs17561351', 'p_SMR_multi': 2.638002e-25, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.17244e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1364278', 'Gene': 'PVRL2', 'topRSID': 'rs4452060', 'p_SMR_multi': 3.959067e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0005228714}, {'UUID': 'NDD_SMR_genes_all_update_text_1673394', 'Gene': 'PVRL2', 'topRSID': 'rs60389450', 'p_SMR_multi': 1.56473e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001337955}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1844 | Q11 | Are there any CTD-2651B20.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CTD-2651B20.3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTD-2651B20.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.913 | Q11 | Are there any ZNF668 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF668 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2303222
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.05e-08; HEIDI: 2.4671e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF668' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501476', 'Gene': 'ZNF668', 'topRSID': 'rs2303222', 'p_SMR_multi': 8.050569e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002467109}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1141 | Q11 | Are there any OR2A25 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Cortex samples tested there are no SNPs within the gene OR2A25 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'OR2A25' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.180 | Q11 | Are there any MAPK3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MAPK3 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55732507
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.60e-11; HEIDI: 6.3508e-05
• rs8061772
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.58e-06; HEIDI: 6.2884e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MAPK3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501448', 'Gene': 'MAPK3', 'topRSID': 'rs55732507', 'p_SMR_multi': 2.599191e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.350792e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_577443', 'Gene': 'MAPK3', 'topRSID': 'rs8061772', 'p_SMR_multi': 1.583699e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0006288385}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.729 | Q11 | Are there any FAM111B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FAM111B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM111B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1273 | Q11 | Are there any NSF SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the NSF gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs62074125
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.92e-07; HEIDI: 3.6361e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NSF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1502459', 'Gene': 'NSF', 'topRSID': 'rs62074125', 'p_SMR_multi': 4.92066e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003636118}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.89 | Q11 | Are there any GPR98 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene GPR98 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GPR98' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1410 | Q11 | Are there any UBTD1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene UBTD1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UBTD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1900 | Q11 | Are there any FLJ30594 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene FLJ30594 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FLJ30594' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.463 | Q11 | Are there any TSBP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TSBP1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs9469094
• Cortex: Adjusted SMR multi-SNP P-value: 4.21e-08; HEIDI: 4.8119e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TSBP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1109082', 'Gene': 'TSBP1', 'topRSID': 'rs9469094', 'p_SMR_multi': 4.212407e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.4811921}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1830 | Q11 | Are there any RP11-120K18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-120K18.3 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11150614
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.67e-07; HEIDI: 1.2762e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-120K18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563821', 'Gene': 'RP11-120K18.3', 'topRSID': 'rs11150614', 'p_SMR_multi': 3.669227e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1276231}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.55 | Q11 | Are there any ZUFSP SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZUFSP that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZUFSP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1503 | Q11 | Are there any RP1-81D8.4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Liver samples tested there are no SNPs within the gene RP1-81D8.4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP1-81D8.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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