uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
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|---|---|---|---|---|---|---|---|---|
Q11.650 | Q11 | Are there any FCRLA SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene FCRLA that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'FCRLA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.684 | Q11 | Are there any RP11-538P18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-538P18.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-538P18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.224 | Q11 | Are there any SFTA2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SFTA2 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2233980
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.14e-08; HEIDI: 2.2532e-02
• rs3132556
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.03e-07; HEIDI: 1.3240e-01
• rs2233974
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.04e-07; HEIDI: 1.0480e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SFTA2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620616', 'Gene': 'SFTA2', 'topRSID': 'rs2233980', 'p_SMR_multi': 4.13716e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02253225}, {'UUID': 'NDD_SMR_genes_all_update_text_620617', 'Gene': 'SFTA2', 'topRSID': 'rs3132556', 'p_SMR_multi': 1.025352e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1323954}, {'UUID': 'NDD_SMR_genes_all_update_text_620615', 'Gene': 'SFTA2', 'topRSID': 'rs2233974', 'p_SMR_multi': 2.037498e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1048014}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.116 | Q11 | Are there any IL17D SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene IL17D that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'IL17D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1552 | Q11 | Are there any AL354718.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AL354718.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AL354718.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1303 | Q11 | Are there any CD55 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CD55 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs891376
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.92e-09; HEIDI: 4.6553e-05
• rs7545125
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.09e-09; HEIDI: 2.3917e-05
• rs2490261
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.53e-07; HEIDI: 1.2923e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD55' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1491150', 'Gene': 'CD55', 'topRSID': 'rs891376', 'p_SMR_multi': 1.915107e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.65526e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_655837', 'Gene': 'CD55', 'topRSID': 'rs7545125', 'p_SMR_multi': 7.09095e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.39175e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_41240', 'Gene': 'CD55', 'topRSID': 'rs2490261', 'p_SMR_multi': 1.534098e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.292324e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.987 | Q11 | Are there any CTD-2540L5.6 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene CTD-2540L5.6 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2540L5.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.177 | Q11 | Are there any C22orf46 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C22orf46 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C22orf46' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1650 | Q11 | Are there any VPS13A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene VPS13A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'VPS13A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.596 | Q11 | Are there any THUMPD3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Blood, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene THUMPD3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'THUMPD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1560 | Q11 | Are there any RP11-431M7.3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-431M7.3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-431M7.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.19 | Q11 | Are there any TRIOBP SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TRIOBP that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TRIOBP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.429 | Q11 | Are there any TNKS2-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TNKS2-AS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TNKS2-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1345 | Q11 | Are there any RNF34 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RNF34 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RNF34' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.289 | Q11 | Are there any MYBPC3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MYBPC3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11039200
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.15e-07; HEIDI: 8.6164e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MYBPC3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498212', 'Gene': 'MYBPC3', 'topRSID': 'rs11039200', 'p_SMR_multi': 1.146533e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008616443}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1584 | Q11 | Are there any TMEM219 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TMEM219 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TMEM219' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.434 | Q11 | Are there any OR13A1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene OR13A1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'OR13A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1640 | Q11 | Are there any PCSK7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PCSK7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PCSK7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1245 | Q11 | Are there any ARL17A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ARL17A gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2532233
• Cortex: Adjusted SMR multi-SNP P-value: 1.16e-07; HEIDI: -9.9990e+03
• rs58879558
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.12e-07; HEIDI: 5.5704e-01
• rs62074125
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.60e-07; HEIDI: 5.6622e-08
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.55e-06; HEIDI: 3.8622e-07
• rs2696466
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 9.79e-07; HEIDI: 2.6002e-03
• rs2732650
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.76e-06; HEIDI: -9.9990e+03
• rs17573607
• Hypothalamus: Adjusted SMR multi-SNP P-value: 2.93e-06; HEIDI: 4.6477e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ARL17A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1106834', 'Gene': 'ARL17A', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.156287e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1396753', 'Gene': 'ARL17A', 'topRSID': 'rs58879558', 'p_SMR_multi': 2.124628e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.5570384}, {'UUID': 'NDD_SMR_genes_all_update_text_1502457', 'Gene': 'ARL17A', 'topRSID': 'rs62074125', 'p_SMR_multi': 2.59862e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.662189e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1203023', 'Gene': 'ARL17A', 'topRSID': 'rs2696466', 'p_SMR_multi': 9.787664e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002600192}, {'UUID': 'NDD_SMR_genes_all_update_text_1291769', 'Gene': 'ARL17A', 'topRSID': 'rs62074125', 'p_SMR_multi': 2.553728e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 3.862198e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1343162', 'Gene': 'ARL17A', 'topRSID': 'rs2732650', 'p_SMR_multi': 2.755616e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1454365', 'Gene': 'ARL17A', 'topRSID': 'rs17573607', 'p_SMR_multi': 2.926866e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.4647684}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.676 | Q11 | Are there any SGK3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SGK3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SGK3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.32 | Q11 | Are there any TMEM106B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TMEM106B gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs3807865
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.81e-07; HEIDI: 3.6198e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TMEM106B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_583798', 'Gene': 'TMEM106B', 'topRSID': 'rs3807865', 'p_SMR_multi': 9.805484e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3619829}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.934 | Q11 | Are there any KANSL1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the KANSL1-AS1 gene has 2 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.66e-48; HEIDI: 8.5446e-10
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.46e-41; HEIDI: 2.6456e-08
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.35e-40; HEIDI: -9.9990e+03
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.89e-37; HEIDI: 1.3449e-13
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.87e-32; HEIDI: 5.9343e-11
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 4.98e-21; HEIDI: 4.3441e-13
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.24e-20; HEIDI: 2.1358e-09
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.83e-19; HEIDI: 3.8591e-13
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.82e-18; HEIDI: 4.8186e-13
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.95e-17; HEIDI: 5.2705e-09
• Hypothalamus: Adjusted SMR multi-SNP P-value: 4.89e-17; HEIDI: 3.4017e-07
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 3.64e-16; HEIDI: 3.5894e-10
• Amygdala: Adjusted SMR multi-SNP P-value: 3.76e-14; HEIDI: 2.3881e-09
• rs1981997
• Cortex: Adjusted SMR multi-SNP P-value: 7.36e-23; HEIDI: 4.8913e-21
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.57e-22; HEIDI: 5.3054e-17
• Liver: Adjusted SMR multi-SNP P-value: 1.09e-21; HEIDI: 4.6903e-14
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.87e-19; HEIDI: 4.5728e-18
• Substantia nigra: Adjusted SMR multi-SNP P-value: 3.35e-12; HEIDI: 3.2170e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KANSL1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579422', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 7.658957999999999e-48, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.544617e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1646044', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 5.463693999999998e-41, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.645557e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1444273', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.3471999999999999e-40, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1375930', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 9.889983e-37, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.344879e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1684935', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.140282e-35, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.982077e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1336291', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.868354e-32, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 5.934329e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1264982', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 7.363979e-23, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.891331e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1714156', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 8.571901000000001e-22, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 5.305356000000001e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1478187', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.08548e-21, 'Omic_tissue': 'Liver', 'p_HEIDI': 4.690342e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1732395', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 4.976284e-21, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 4.344131e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1283703', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.238614e-20, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 2.135793e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1194217', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.830596e-19, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 3.85912e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1596822', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.873105e-19, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 4.5728e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1170873', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.818021e-18, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 4.818611e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1388482', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.9528980000000002e-17, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 5.270543e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1464418', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 4.891060000000001e-17, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 3.401674e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1489538', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.635269e-16, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 3.589355e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1604713', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.764575e-14, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 2.388099e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1452482', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.350931e-12, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 3.216973e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.982 | Q11 | Are there any BMP4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene BMP4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'BMP4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.217 | Q11 | Are there any RP11-95I16.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-95I16.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-95I16.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1130 | Q11 | Are there any RP1-95L4.4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP1-95L4.4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP1-95L4.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.330 | Q11 | Are there any RP11-798G7.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-798G7.5 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.36e-11; HEIDI: 8.2175e-05
• rs112995313
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.39e-07; HEIDI: 3.9622e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-798G7.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564776', 'Gene': 'RP11-798G7.5', 'topRSID': 'rs2532233', 'p_SMR_multi': 2.359444e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.217541e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1640213', 'Gene': 'RP11-798G7.5', 'topRSID': 'rs112995313', 'p_SMR_multi': 4.390332e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3962181}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.566 | Q11 | Are there any LBX1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LBX1-AS1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LBX1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1112 | Q11 | Are there any LACTB SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LACTB gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2729779
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.14e-08; HEIDI: 1.5125e-08
• rs2652823
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.32e-08; HEIDI: 5.9776e-07
• rs1472631
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 3.18e-07; HEIDI: 3.6910e-02
• rs4775633
• Cortex: Adjusted SMR multi-SNP P-value: 4.60e-07; HEIDI: 1.6101e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LACTB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500801', 'Gene': 'LACTB', 'topRSID': 'rs2729779', 'p_SMR_multi': 7.143396e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.512549e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1395768', 'Gene': 'LACTB', 'topRSID': 'rs2652823', 'p_SMR_multi': 8.319234e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.97761e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1342449', 'Gene': 'LACTB', 'topRSID': 'rs1472631', 'p_SMR_multi': 3.176604e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.03690984}, {'UUID': 'NDD_SMR_genes_all_update_text_1110001', 'Gene': 'LACTB', 'topRSID': 'rs4775633', 'p_SMR_multi': 4.595053e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.001610107}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.707 | Q11 | Are there any RP11-982M15.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-982M15.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-982M15.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1979 | Q11 | Are there any ATP4B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ATP4B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ATP4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1189 | Q11 | Are there any TRBV7-5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV7-5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TRBV7-5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.345 | Q11 | Are there any TRBV29-1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV29-1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'TRBV29-1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.636 | Q11 | Are there any ZBTB5 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZBTB5 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZBTB5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.150 | Q11 | Are there any DNAJC19P5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene DNAJC19P5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DNAJC19P5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1197 | Q11 | Are there any TRDD3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRDD3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TRDD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.365 | Q11 | Are there any MRP63 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MRP63 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MRP63' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.86 | Q11 | Are there any CASTOR3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CASTOR3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs17309333
• Cortex: Adjusted SMR multi-SNP P-value: 1.21e-06; HEIDI: 5.5810e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CASTOR3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1105974', 'Gene': 'CASTOR3', 'topRSID': 'rs17309333', 'p_SMR_multi': 1.214914e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.5580988}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.49 | Q11 | Are there any CNN2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CNN2 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs113337161
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.83e-14; HEIDI: 8.5985e-10
• rs7247087
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.30e-10; HEIDI: 9.2914e-15
• rs2304260
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.79e-10; HEIDI: 5.9605e-09
• rs111745465
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.47e-08; HEIDI: 7.6937e-16
• rs4807440
• Cortex: Adjusted SMR multi-SNP P-value: 4.32e-07; HEIDI: 3.6949e-08
• rs3087680
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.39e-06; HEIDI: 6.5046e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CNN2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503131', 'Gene': 'CNN2', 'topRSID': 'rs113337161', 'p_SMR_multi': 3.829816e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.598535e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_634277', 'Gene': 'CNN2', 'topRSID': 'rs7247087', 'p_SMR_multi': 1.304171e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.291437e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_634276', 'Gene': 'CNN2', 'topRSID': 'rs2304260', 'p_SMR_multi': 1.786012e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.960515e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_634278', 'Gene': 'CNN2', 'topRSID': 'rs111745465', 'p_SMR_multi': 4.465852e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.693673e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1107631', 'Gene': 'CNN2', 'topRSID': 'rs4807440', 'p_SMR_multi': 4.321563e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 3.694892e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1652807', 'Gene': 'CNN2', 'topRSID': 'rs3087680', 'p_SMR_multi': 1.394849e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00650461}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.474 | Q11 | Are there any PEX19 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene PEX19 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PEX19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.158 | Q11 | Are there any DEXI SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene DEXI that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DEXI' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.764 | Q11 | Are there any RGL4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene RGL4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RGL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1027 | Q11 | Are there any RP11-587D21.4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-587D21.4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-587D21.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1200 | Q11 | Are there any ADAMTS7P2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene ADAMTS7P2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ADAMTS7P2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1404 | Q11 | Are there any KCNK2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene KCNK2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KCNK2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1202 | Q11 | Are there any COL27A1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene COL27A1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'COL27A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1631 | Q11 | Are there any FAM193B SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FAM193B that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'FAM193B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.506 | Q11 | Are there any SFT2D3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene SFT2D3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SFT2D3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1670 | Q11 | Are there any MRE11 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Hippocampus and Cortex samples tested there are no SNPs within the gene MRE11 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MRE11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.182 | Q11 | Are there any RP11-136I14.5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-136I14.5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-136I14.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1419 | Q11 | Are there any TMOD3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene TMOD3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TMOD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1014 | Q11 | Are there any HIST1H2BN SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene HIST1H2BN that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HIST1H2BN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1978 | Q11 | Are there any EFNA4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the EFNA4 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs3765087
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.68e-06; HEIDI: 2.0668e-02
• rs12743272
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.68e-06; HEIDI: 5.7567e-01
• rs11264304
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.84e-06; HEIDI: 4.8491e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'EFNA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_415494', 'Gene': 'EFNA4', 'topRSID': 'rs3765087', 'p_SMR_multi': 1.676525e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02066825}, {'UUID': 'NDD_SMR_genes_all_update_text_415493', 'Gene': 'EFNA4', 'topRSID': 'rs12743272', 'p_SMR_multi': 1.684602e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.5756692}, {'UUID': 'NDD_SMR_genes_all_update_text_415495', 'Gene': 'EFNA4', 'topRSID': 'rs11264304', 'p_SMR_multi': 2.836025e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0004849142}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.864 | Q11 | Are there any SLC45A1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SLC45A1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SLC45A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1620 | Q11 | Are there any CTAGE7P SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTAGE7P that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTAGE7P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.534 | Q11 | Are there any CYP2A6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene CYP2A6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CYP2A6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.350 | Q11 | Are there any RPS26P8 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RPS26P8 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2732705
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.84e-06; HEIDI: 4.7832e-02
• rs55974014
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.81e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RPS26P8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203003', 'Gene': 'RPS26P8', 'topRSID': 'rs2732705', 'p_SMR_multi': 1.839777e-06, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.04783226}, {'UUID': 'NDD_SMR_genes_all_update_text_1291756', 'Gene': 'RPS26P8', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.810521e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1389 | Q11 | Are there any RP11-124G5.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-124G5.3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-124G5.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1961 | Q11 | Are there any THAP1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene THAP1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'THAP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1301 | Q11 | Are there any SCFD1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | Yes, the SCFD1 gene has 2 SNPs that are statistically significant in Amyotrophic Lateral Sclerosis. Here are the SNPs along with their adjusted SMR p-values:
• rs7144204
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.01e-07; HEIDI: 1.8172e-01
• rs229243
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.95e-06; HEIDI: 3.3799e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SCFD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1515764', 'Gene': 'SCFD1', 'topRSID': 'rs7144204', 'p_SMR_multi': 7.008029e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1817184}, {'UUID': 'NDD_SMR_genes_all_update_text_1405224', 'Gene': 'SCFD1', 'topRSID': 'rs229243', 'p_SMR_multi': 2.949612e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.000337994}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1973 | Q11 | Are there any MAPT-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MAPT-AS1 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1819040
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.74e-07; HEIDI: 8.5587e-03
• rs112310745
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.63e-07; HEIDI: 2.5253e-02
• rs10445363
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.02e-06; HEIDI: 5.9937e-02
• rs113790915
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.49e-06; HEIDI: 4.0879e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MAPT-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203009', 'Gene': 'MAPT-AS1', 'topRSID': 'rs1819040', 'p_SMR_multi': 1.741788e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.008558721}, {'UUID': 'NDD_SMR_genes_all_update_text_591182', 'Gene': 'MAPT-AS1', 'topRSID': 'rs112310745', 'p_SMR_multi': 7.625542e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02525318}, {'UUID': 'NDD_SMR_genes_all_update_text_591183', 'Gene': 'MAPT-AS1', 'topRSID': 'rs10445363', 'p_SMR_multi': 1.020521e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05993741}, {'UUID': 'NDD_SMR_genes_all_update_text_591185', 'Gene': 'MAPT-AS1', 'topRSID': 'rs113790915', 'p_SMR_multi': 1.492358e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04087851}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1980 | Q11 | Are there any LA16c-325D7.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LA16c-325D7.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LA16c-325D7.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.608 | Q11 | Are there any MYO7B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene MYO7B that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MYO7B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1050 | Q11 | Are there any SETDB1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene SETDB1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SETDB1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.246 | Q11 | Are there any HSPA4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene HSPA4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HSPA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1681 | Q11 | Are there any RP11-426L16.8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene RP11-426L16.8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-426L16.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1799 | Q11 | Are there any EIF5AL1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene EIF5AL1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'EIF5AL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1717 | Q11 | Are there any LINC00240 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene LINC00240 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'LINC00240' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.316 | Q11 | Are there any JPT2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene JPT2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'JPT2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.441 | Q11 | Are there any NDUFS2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the NDUFS2 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4379692
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.06e-09; HEIDI: 5.8351e-02
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.24e-06; HEIDI: 2.7616e-02
• rs1136224
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 7.05e-08; HEIDI: 1.7316e-06
• rs33941127
• Cortex: Adjusted SMR multi-SNP P-value: 6.50e-07; HEIDI: 2.2331e-01
• rs2070901
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.25e-07; HEIDI: 1.8770e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NDUFS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1490907', 'Gene': 'NDUFS2', 'topRSID': 'rs4379692', 'p_SMR_multi': 4.056329e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05835141}, {'UUID': 'NDD_SMR_genes_all_update_text_1389451', 'Gene': 'NDUFS2', 'topRSID': 'rs1136224', 'p_SMR_multi': 7.052437e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.731567e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1105079', 'Gene': 'NDUFS2', 'topRSID': 'rs33941127', 'p_SMR_multi': 6.50274e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.2233147}, {'UUID': 'NDD_SMR_genes_all_update_text_654689', 'Gene': 'NDUFS2', 'topRSID': 'rs2070901', 'p_SMR_multi': 8.249956e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1877015}, {'UUID': 'NDD_SMR_genes_all_update_text_1605358', 'Gene': 'NDUFS2', 'topRSID': 'rs4379692', 'p_SMR_multi': 2.241432e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02761572}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1899 | Q11 | Are there any ZDHHC4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZDHHC4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZDHHC4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1637 | Q11 | Are there any LGALS9 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LGALS9 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LGALS9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.312 | Q11 | Are there any FBXL16 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene FBXL16 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FBXL16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.436 | Q11 | Are there any CELF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CELF1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11039409
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.23e-06; HEIDI: 3.7540e-01
• rs7124681
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.97e-06; HEIDI: 2.7392e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CELF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_608497', 'Gene': 'CELF1', 'topRSID': 'rs11039409', 'p_SMR_multi': 1.22676e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3753996}, {'UUID': 'NDD_SMR_genes_all_update_text_608498', 'Gene': 'CELF1', 'topRSID': 'rs7124681', 'p_SMR_multi': 1.972961e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.739152e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_608496', 'Gene': 'CELF1', 'topRSID': 'rs11039409', 'p_SMR_multi': 2.661723e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4146672}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.667 | Q11 | Are there any ARIH2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Liver and Whole Blood samples tested there are no SNPs within the gene ARIH2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ARIH2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.376 | Q11 | Are there any AP006294.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AP006294.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AP006294.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.572 | Q11 | Are there any RP11-92G12.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-92G12.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-92G12.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1226 | Q11 | Are there any ASPHD1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ASPHD1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11644048
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.82e-08; HEIDI: 1.8746e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ASPHD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577410', 'Gene': 'ASPHD1', 'topRSID': 'rs11644048', 'p_SMR_multi': 5.817597e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001874638}, {'UUID': 'NDD_SMR_genes_all_update_text_577408', 'Gene': 'ASPHD1', 'topRSID': 'rs11644048', 'p_SMR_multi': 1.092309e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000688876}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.184 | Q11 | Are there any C7orf61 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C7orf61 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7787620
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.81e-08; HEIDI: 5.6305e-07 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C7orf61' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495811', 'Gene': 'C7orf61', 'topRSID': 'rs7787620', 'p_SMR_multi': 3.813436e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.630473e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1115 | Q11 | Are there any SFRP1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SFRP1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SFRP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.628 | Q11 | Are there any TRIM39-RPP21 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene TRIM39-RPP21 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TRIM39-RPP21' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1910 | Q11 | Are there any ITGAX SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ITGAX gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11574631
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.17e-08; HEIDI: 3.2628e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ITGAX' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501486', 'Gene': 'ITGAX', 'topRSID': 'rs11574631', 'p_SMR_multi': 3.173201e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003262819}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1192 | Q11 | Are there any ADAM10 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ADAM10 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7161799
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.33e-06; HEIDI: 2.3743e-01
• rs2250583
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.60e-06; HEIDI: 7.7902e-02
• rs1427280
• Cortex: Adjusted SMR multi-SNP P-value: 2.62e-06; HEIDI: 9.7695e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADAM10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500785', 'Gene': 'ADAM10', 'topRSID': 'rs7161799', 'p_SMR_multi': 1.325576e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2374332}, {'UUID': 'NDD_SMR_genes_all_update_text_105563', 'Gene': 'ADAM10', 'topRSID': 'rs2250583', 'p_SMR_multi': 2.600605e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.07790174}, {'UUID': 'NDD_SMR_genes_all_update_text_1109990', 'Gene': 'ADAM10', 'topRSID': 'rs1427280', 'p_SMR_multi': 2.621155e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.009769548}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.940 | Q11 | Are there any MT1XP1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Whole Blood and Cerebellum samples tested there are no SNPs within the gene MT1XP1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MT1XP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1774 | Q11 | Are there any MSH5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MSH5 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs3117577
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.95e-08; HEIDI: 8.5262e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MSH5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621175', 'Gene': 'MSH5', 'topRSID': 'rs3117577', 'p_SMR_multi': 1.947452e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00852616}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1842 | Q11 | Are there any TMEM175 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the TMEM175 gene has 13 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs6813110
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.62e-11; HEIDI: 1.2210e-04
• rs11248057
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.33e-11; HEIDI: 6.4793e-01
• rs11729289
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.15e-11; HEIDI: 8.4410e-03
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.36e-06; HEIDI: 1.1312e-11
• rs11248059
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.26e-11; HEIDI: 4.8399e-03
• rs10008187
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.41e-10; HEIDI: 4.3332e-01
• rs935977
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.83e-10; HEIDI: 1.0088e-02
• rs6848199
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.17e-09; HEIDI: 2.6074e-01
• rs17783233
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.68e-07; HEIDI: 5.7276e-03
• rs73211813
• Cerebellum: Adjusted SMR multi-SNP P-value: 7.71e-07; HEIDI: 3.3036e-01
• rs2290403
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.38e-07; HEIDI: 8.0564e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TMEM175' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996283', 'Gene': 'TMEM175', 'topRSID': 'rs6813110', 'p_SMR_multi': 2.618289e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001221027}, {'UUID': 'NDD_SMR_genes_all_update_text_996290', 'Gene': 'TMEM175', 'topRSID': 'rs11248057', 'p_SMR_multi': 4.328358e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6479261}, {'UUID': 'NDD_SMR_genes_all_update_text_996285', 'Gene': 'TMEM175', 'topRSID': 'rs11729289', 'p_SMR_multi': 5.154386e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008440966}, {'UUID': 'NDD_SMR_genes_all_update_text_996291', 'Gene': 'TMEM175', 'topRSID': 'rs11248059', 'p_SMR_multi': 5.264583e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004839926}, {'UUID': 'NDD_SMR_genes_all_update_text_996286', 'Gene': 'TMEM175', 'topRSID': 'rs6813110', 'p_SMR_multi': 1.936992e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.006638}, {'UUID': 'NDD_SMR_genes_all_update_text_429841', 'Gene': 'TMEM175', 'topRSID': 'rs10008187', 'p_SMR_multi': 4.414637e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4333231}, {'UUID': 'NDD_SMR_genes_all_update_text_996287', 'Gene': 'TMEM175', 'topRSID': 'rs6813110', 'p_SMR_multi': 4.726969e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00386215}, {'UUID': 'NDD_SMR_genes_all_update_text_429843', 'Gene': 'TMEM175', 'topRSID': 'rs10008187', 'p_SMR_multi': 6.686346e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3099254}, {'UUID': 'NDD_SMR_genes_all_update_text_996282', 'Gene': 'TMEM175', 'topRSID': 'rs935977', 'p_SMR_multi': 7.831054e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01008769}, {'UUID': 'NDD_SMR_genes_all_update_text_429842', 'Gene': 'TMEM175', 'topRSID': 'rs6848199', 'p_SMR_multi': 1.173192e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2607437}, {'UUID': 'NDD_SMR_genes_all_update_text_429844', 'Gene': 'TMEM175', 'topRSID': 'rs10008187', 'p_SMR_multi': 1.397854e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2163939}, {'UUID': 'NDD_SMR_genes_all_update_text_996288', 'Gene': 'TMEM175', 'topRSID': 'rs6813110', 'p_SMR_multi': 4.653432e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001235079}, {'UUID': 'NDD_SMR_genes_all_update_text_1555639', 'Gene': 'TMEM175', 'topRSID': 'rs11248057', 'p_SMR_multi': 3.72213e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.827779e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_996284', 'Gene': 'TMEM175', 'topRSID': 'rs935977', 'p_SMR_multi': 5.342432e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009309811}, {'UUID': 'NDD_SMR_genes_all_update_text_429848', 'Gene': 'TMEM175', 'topRSID': 'rs17783233', 'p_SMR_multi': 6.678886e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.005727583}, {'UUID': 'NDD_SMR_genes_all_update_text_1707342', 'Gene': 'TMEM175', 'topRSID': 'rs73211813', 'p_SMR_multi': 7.710669e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.3303648}, {'UUID': 'NDD_SMR_genes_all_update_text_429845', 'Gene': 'TMEM175', 'topRSID': 'rs2290403', 'p_SMR_multi': 9.382849e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.056445e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_996289', 'Gene': 'TMEM175', 'topRSID': 'rs11724898', 'p_SMR_multi': 1.047498e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01186439}, {'UUID': 'NDD_SMR_genes_all_update_text_429846', 'Gene': 'TMEM175', 'topRSID': 'rs6842808', 'p_SMR_multi': 2.308662e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.344941e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1188708', 'Gene': 'TMEM175', 'topRSID': 'rs4690203', 'p_SMR_multi': 2.332517e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.007003691}, {'UUID': 'NDD_SMR_genes_all_update_text_429839', 'Gene': 'TMEM175', 'topRSID': 'rs11729289', 'p_SMR_multi': 2.360771e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.131187e-11}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1331 | Q11 | Are there any HAS2-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene HAS2-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HAS2-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.300 | Q11 | Are there any UQCC SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene UQCC that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'UQCC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1619 | Q11 | Are there any DNAJB11 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene DNAJB11 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DNAJB11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.467 | Q11 | Are there any SNCA SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the SNCA gene has 6 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs2301134
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.12e-10; HEIDI: 8.6050e-01
• rs3756059
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.82e-10; HEIDI: 2.3214e-04
• rs2245801
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.16e-10; HEIDI: 2.8788e-01
• rs1372520
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.06e-09; HEIDI: 3.1127e-02
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.80e-09; HEIDI: 6.6506e-03
• rs2301135
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.48e-06; HEIDI: 7.8678e-01
• rs6817026
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.74e-06; HEIDI: 4.5179e-09
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SNCA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_934862', 'Gene': 'SNCA', 'topRSID': 'rs2301134', 'p_SMR_multi': 3.123872e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.8604982}, {'UUID': 'NDD_SMR_genes_all_update_text_338827', 'Gene': 'SNCA', 'topRSID': 'rs3756059', 'p_SMR_multi': 4.824404e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0002321407}, {'UUID': 'NDD_SMR_genes_all_update_text_1540410', 'Gene': 'SNCA', 'topRSID': 'rs2245801', 'p_SMR_multi': 7.155271e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.287884}, {'UUID': 'NDD_SMR_genes_all_update_text_934864', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 2.056567e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03112726}, {'UUID': 'NDD_SMR_genes_all_update_text_934863', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 2.67361e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05096295}, {'UUID': 'NDD_SMR_genes_all_update_text_338828', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 3.798323e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.006650634}, {'UUID': 'NDD_SMR_genes_all_update_text_934866', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 1.648058e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02908966}, {'UUID': 'NDD_SMR_genes_all_update_text_934865', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 1.862795e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08814268}, {'UUID': 'NDD_SMR_genes_all_update_text_934867', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 2.866823e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1044821}, {'UUID': 'NDD_SMR_genes_all_update_text_934861', 'Gene': 'SNCA', 'topRSID': 'rs2301135', 'p_SMR_multi': 1.47658e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.7867827}, {'UUID': 'NDD_SMR_genes_all_update_text_338831', 'Gene': 'SNCA', 'topRSID': 'rs1372520', 'p_SMR_multi': 2.501519e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.130772}, {'UUID': 'NDD_SMR_genes_all_update_text_338829', 'Gene': 'SNCA', 'topRSID': 'rs6817026', 'p_SMR_multi': 2.742749e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.517936e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1302 | Q11 | Are there any ID1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ID1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ID1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1250 | Q11 | Are there any MTERF2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene MTERF2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MTERF2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.383 | Q11 | Are there any RP11-671M22.6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-671M22.6 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-671M22.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1768 | Q11 | Are there any RP11-10C24.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Caudate Basal Ganglia, Tibial Nerve, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-10C24.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-10C24.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.108 | Q11 | Are there any CTB-83J4.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTB-83J4.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CTB-83J4.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.129 | Q11 | Are there any CACNB2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene CACNB2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CACNB2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1131 | Q11 | Are there any CCNE2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CCNE2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2515226
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.50e-06; HEIDI: 2.7568e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CCNE2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496487', 'Gene': 'CCNE2', 'topRSID': 'rs2515226', 'p_SMR_multi': 2.499329e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2756845}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.872 | Q11 | Are there any AC012146.7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AC012146.7 gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs73976310
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.72e-08; HEIDI: 4.8877e-03
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.17e-07; HEIDI: 2.4217e-01
• rs1054697
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.05e-08; HEIDI: 6.6899e-04
• rs73976311
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.69e-07; HEIDI: 5.1314e-06
• rs113831399
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.72e-07; HEIDI: 1.0544e-01
• rs56197642
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 5.26e-07; HEIDI: 1.7872e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.15e-06; HEIDI: 1.9557e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.46e-06; HEIDI: 1.6511e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC012146.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501926', 'Gene': 'AC012146.7', 'topRSID': 'rs73976310', 'p_SMR_multi': 1.719533e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004887671}, {'UUID': 'NDD_SMR_genes_all_update_text_1202711', 'Gene': 'AC012146.7', 'topRSID': 'rs1054697', 'p_SMR_multi': 2.054355e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.000668988}, {'UUID': 'NDD_SMR_genes_all_update_text_1396457', 'Gene': 'AC012146.7', 'topRSID': 'rs73976311', 'p_SMR_multi': 1.693054e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.131379e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1291507', 'Gene': 'AC012146.7', 'topRSID': 'rs113831399', 'p_SMR_multi': 2.72283e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.1054384}, {'UUID': 'NDD_SMR_genes_all_update_text_1610627', 'Gene': 'AC012146.7', 'topRSID': 'rs73976310', 'p_SMR_multi': 3.174282e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2421744}, {'UUID': 'NDD_SMR_genes_all_update_text_1342982', 'Gene': 'AC012146.7', 'topRSID': 'rs56197642', 'p_SMR_multi': 5.264911e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.1787238}, {'UUID': 'NDD_SMR_genes_all_update_text_1717291', 'Gene': 'AC012146.7', 'topRSID': 'rs56197642', 'p_SMR_multi': 1.151959e-06, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.1955708}, {'UUID': 'NDD_SMR_genes_all_update_text_1454298', 'Gene': 'AC012146.7', 'topRSID': 'rs56197642', 'p_SMR_multi': 1.461988e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.1651061}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.360 | Q11 | Are there any F3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene F3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'F3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1617 | Q11 | Are there any LCE1B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene LCE1B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'LCE1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.689 | Q11 | Are there any LDLRAD4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LDLRAD4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LDLRAD4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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