uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.1787 | Q11 | Are there any USP48 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene USP48 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'USP48' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1467 | Q11 | Are there any ABCF3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ABCF3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ABCF3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.212 | Q11 | Are there any PTPN12 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene PTPN12 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PTPN12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.880 | Q11 | Are there any MAMDC2-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene MAMDC2-AS1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MAMDC2-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.143 | Q11 | Are there any RP11-263K4.3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-263K4.3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-263K4.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1439 | Q11 | Are there any MSI1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene MSI1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MSI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1341 | Q11 | Are there any RP11-293E1.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-293E1.1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs111327992
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.76e-06; HEIDI: -9.9990e+03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-293E1.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242270', 'Gene': 'RP11-293E1.1', 'topRSID': 'rs111327992', 'p_SMR_multi': 1.757393e-06, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1786 | Q11 | Are there any RP11-815D16.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-815D16.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-815D16.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1575 | Q11 | Are there any RP4-575N6.5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP4-575N6.5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP4-575N6.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1865 | Q11 | Are there any SSC5D SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SSC5D that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SSC5D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1749 | Q11 | Are there any TOMM40 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the TOMM40 gene has 2 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs59007384
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.14e-08; HEIDI: 5.3022e-01
• rs7259620
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.57e-08; HEIDI: 9.8381e-05
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.75e-08; HEIDI: 3.9328e-15
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TOMM40' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_402972', 'Gene': 'TOMM40', 'topRSID': 'rs59007384', 'p_SMR_multi': 4.137428e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.5302237}, {'UUID': 'NDD_SMR_genes_all_update_text_1426980', 'Gene': 'TOMM40', 'topRSID': 'rs7259620', 'p_SMR_multi': 4.566302e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 9.838141e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1633475', 'Gene': 'TOMM40', 'topRSID': 'rs7259620', 'p_SMR_multi': 9.749371e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.932821e-15}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.718 | Q11 | Are there any CRHR1-IT1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CRHR1-IT1 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62056913
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.51e-06; HEIDI: -9.9990e+03
• rs2696532
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.77e-06; HEIDI: -9.9990e+03
• rs62055888
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.99e-06; HEIDI: -9.9990e+03
• rs4564621
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.14e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CRHR1-IT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1396747', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62056913', 'p_SMR_multi': 1.509972e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1652497', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs2696532', 'p_SMR_multi': 1.771568e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1343151', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62055888', 'p_SMR_multi': 1.988466e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1291757', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs4564621', 'p_SMR_multi': 2.139081e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1936 | Q11 | Are there any RBMXP2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RBMXP2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RBMXP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.852 | Q11 | Are there any HCG27 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the HCG27 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1265098
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.02e-07; HEIDI: 7.7688e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HCG27' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620835', 'Gene': 'HCG27', 'topRSID': 'rs1265098', 'p_SMR_multi': 9.024084e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007768795}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1938 | Q11 | Are there any TREML3P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREML3P gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12529029
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.24e-12; HEIDI: 5.0116e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREML3P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494870', 'Gene': 'TREML3P', 'topRSID': 'rs12529029', 'p_SMR_multi': 4.235785e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005011636}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.11 | Q11 | Are there any ZNF594 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZNF594 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZNF594' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1695 | Q11 | Are there any RP11-151H2.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-151H2.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-151H2.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1124 | Q11 | Are there any RP11-57H14.4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-57H14.4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-57H14.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.286 | Q11 | Are there any RP11-524F11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-524F11.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-524F11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.817 | Q11 | Are there any LINC01056 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LINC01056 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LINC01056' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1092 | Q11 | Are there any CCDC158 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CCDC158 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs72657839
• Cortex: Adjusted SMR multi-SNP P-value: 4.46e-07; HEIDI: 3.9722e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CCDC158' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140436', 'Gene': 'CCDC158', 'topRSID': 'rs72657839', 'p_SMR_multi': 4.459004e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.03972192}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.295 | Q11 | Are there any CRY1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene CRY1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CRY1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.761 | Q11 | Are there any ATG16L2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ATG16L2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ATG16L2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.633 | Q11 | Are there any RP4-683M8.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP4-683M8.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP4-683M8.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.930 | Q11 | Are there any HMHA1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the HMHA1 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs8109683
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.16e-12; HEIDI: 2.3820e-13
• rs2269848
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.82e-12; HEIDI: 9.0551e-18
• rs76957023
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.34e-09; HEIDI: 1.1591e-03
• rs11084881
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.47e-07; HEIDI: 2.9851e-09
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HMHA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503133', 'Gene': 'HMHA1', 'topRSID': 'rs8109683', 'p_SMR_multi': 3.159608e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.381981e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_634294', 'Gene': 'HMHA1', 'topRSID': 'rs2269848', 'p_SMR_multi': 4.823616e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.055138e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_634296', 'Gene': 'HMHA1', 'topRSID': 'rs76957023', 'p_SMR_multi': 8.343997e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001159075}, {'UUID': 'NDD_SMR_genes_all_update_text_634292', 'Gene': 'HMHA1', 'topRSID': 'rs11084881', 'p_SMR_multi': 4.473584e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.985131e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1019 | Q11 | Are there any AC018462.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AC018462.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC018462.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.132 | Q11 | Are there any SETD1A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SETD1A gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7206511
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.31e-09; HEIDI: 4.2541e-01
• rs11150601
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.40e-07; HEIDI: 8.5353e-05
• rs12934900
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.94e-06; HEIDI: 3.7994e-10
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SETD1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563807', 'Gene': 'SETD1A', 'topRSID': 'rs7206511', 'p_SMR_multi': 7.308286e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4254096}, {'UUID': 'NDD_SMR_genes_all_update_text_485446', 'Gene': 'SETD1A', 'topRSID': 'rs11150601', 'p_SMR_multi': 3.404339e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.535299e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1435341', 'Gene': 'SETD1A', 'topRSID': 'rs12934900', 'p_SMR_multi': 1.93981e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.799415e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1175 | Q11 | Are there any ANXA6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ANXA6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ANXA6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.327 | Q11 | Are there any PHF10 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PHF10 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PHF10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1279 | Q11 | Are there any SLX1B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SLX1B gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2083237
• Cortex: Adjusted SMR multi-SNP P-value: 1.92e-08; HEIDI: 4.3762e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLX1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1111642', 'Gene': 'SLX1B', 'topRSID': 'rs2083237', 'p_SMR_multi': 1.921527e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.376231e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1385 | Q11 | Are there any FAM27L SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene FAM27L that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM27L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.951 | Q11 | Are there any TYR SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene TYR that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TYR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1867 | Q11 | Are there any RP11-960L18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-960L18.1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12446759
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.27e-08; HEIDI: 8.0436e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-960L18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501732', 'Gene': 'RP11-960L18.1', 'topRSID': 'rs12446759', 'p_SMR_multi': 3.273907e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08043591}, {'UUID': 'NDD_SMR_genes_all_update_text_1652197', 'Gene': 'RP11-960L18.1', 'topRSID': 'rs12446759', 'p_SMR_multi': 1.702651e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3347655}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1372 | Q11 | Are there any ABHD17C SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ABHD17C that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ABHD17C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1520 | Q11 | Are there any RNU4-65P SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RNU4-65P that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RNU4-65P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.702 | Q11 | Are there any TRAF7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TRAF7 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRAF7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.218 | Q11 | Are there any TRBV7-4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRBV7-4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRBV7-4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1043 | Q11 | Are there any LINC00403 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Brain samples tested there are no SNPs within the gene LINC00403 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LINC00403' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1815 | Q11 | Are there any RP11-1365D11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Tibial Nerve, Skeletal Muscle, Whole Blood, Whole Brain and Cerebellum samples tested there are no SNPs within the gene RP11-1365D11.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-1365D11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.161 | Q11 | Are there any CDSN SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CDSN gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1042148
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.52e-07; HEIDI: 3.7392e-02
• rs3130983
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.06e-06; HEIDI: 1.8848e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CDSN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620705', 'Gene': 'CDSN', 'topRSID': 'rs1042148', 'p_SMR_multi': 3.519033e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03739201}, {'UUID': 'NDD_SMR_genes_all_update_text_620702', 'Gene': 'CDSN', 'topRSID': 'rs3130983', 'p_SMR_multi': 2.060775e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001884845}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1059 | Q11 | Are there any CCDC200 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene CCDC200 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CCDC200' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1243 | Q11 | Are there any CD38 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CD38 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11724635
• Cortex: Adjusted SMR multi-SNP P-value: 5.82e-12; HEIDI: 8.5706e-01
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.93e-10; HEIDI: 9.1018e-01
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.16e-07; HEIDI: 9.4903e-01
• rs3213710
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.47e-11; HEIDI: 2.8383e-13
• rs4698413
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.56e-07; HEIDI: 8.6231e-02
• Cortex: Adjusted SMR multi-SNP P-value: 2.80e-07; HEIDI: 7.2727e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 4.31e-07; HEIDI: 4.4613e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CD38' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140328', 'Gene': 'CD38', 'topRSID': 'rs11724635', 'p_SMR_multi': 5.824364e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.8570616}, {'UUID': 'NDD_SMR_genes_all_update_text_1430256', 'Gene': 'CD38', 'topRSID': 'rs3213710', 'p_SMR_multi': 1.473525e-11, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.838263e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1236251', 'Gene': 'CD38', 'topRSID': 'rs11724635', 'p_SMR_multi': 3.931599e-10, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.9101781}, {'UUID': 'NDD_SMR_genes_all_update_text_1635910', 'Gene': 'CD38', 'topRSID': 'rs11724635', 'p_SMR_multi': 2.157054e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.9490307}, {'UUID': 'NDD_SMR_genes_all_update_text_1279425', 'Gene': 'CD38', 'topRSID': 'rs4698413', 'p_SMR_multi': 2.555706e-07, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.08623055}, {'UUID': 'NDD_SMR_genes_all_update_text_1260001', 'Gene': 'CD38', 'topRSID': 'rs4698413', 'p_SMR_multi': 2.801858e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.7272661}, {'UUID': 'NDD_SMR_genes_all_update_text_1728225', 'Gene': 'CD38', 'topRSID': 'rs4698413', 'p_SMR_multi': 4.311773e-07, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.4461342}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.641 | Q11 | Are there any CTB-57H20.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTB-57H20.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTB-57H20.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.522 | Q11 | Are there any IGHV2-70 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the IGHV2-70 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7153964
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.32e-08; HEIDI: 6.3718e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IGHV2-70' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500567', 'Gene': 'IGHV2-70', 'topRSID': 'rs7153964', 'p_SMR_multi': 9.31673e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.006371822}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1624 | Q11 | Are there any CCT6P1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver and Whole Blood samples tested there are no SNPs within the gene CCT6P1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CCT6P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1522 | Q11 | Are there any MCM2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MCM2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MCM2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.604 | Q11 | Are there any GPX3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | Yes, the GPX3 gene has 1 SNP that is statistically significant in Amyotrophic Lateral Sclerosis:
• rs12518386
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.91e-09; HEIDI: 2.8669e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GPX3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1509996', 'Gene': 'GPX3', 'topRSID': 'rs12518386', 'p_SMR_multi': 1.911096e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002866894}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.198 | Q11 | Are there any AC064836.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC064836.3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC064836.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1644 | Q11 | Are there any IFI44 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene IFI44 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IFI44' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.961 | Q11 | Are there any WDR67 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene WDR67 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'WDR67' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.416 | Q11 | Are there any AC093375.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene AC093375.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC093375.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.99 | Q11 | Are there any CTD-3105H18.7 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Liver samples tested there are no SNPs within the gene CTD-3105H18.7 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTD-3105H18.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.988 | Q11 | Are there any AC005082.12 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the AC005082.12 gene has 6 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs858300
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.99e-09; HEIDI: 2.3048e-02
• rs858283
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.05e-07; HEIDI: 8.4009e-03
• rs858295
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.61e-07; HEIDI: 4.9471e-03
• rs858289
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.29e-06; HEIDI: 1.7925e-01
• rs870476
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.46e-06; HEIDI: 1.5037e-01
• rs1881200
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.62e-06; HEIDI: 1.3845e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC005082.12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1557763', 'Gene': 'AC005082.12', 'topRSID': 'rs858300', 'p_SMR_multi': 8.993726e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02304777}, {'UUID': 'NDD_SMR_genes_all_update_text_1676522', 'Gene': 'AC005082.12', 'topRSID': 'rs858283', 'p_SMR_multi': 7.050288e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008400882}, {'UUID': 'NDD_SMR_genes_all_update_text_447892', 'Gene': 'AC005082.12', 'topRSID': 'rs858295', 'p_SMR_multi': 7.614746e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.00494714}, {'UUID': 'NDD_SMR_genes_all_update_text_1324773', 'Gene': 'AC005082.12', 'topRSID': 'rs858289', 'p_SMR_multi': 2.294855e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.1792471}, {'UUID': 'NDD_SMR_genes_all_update_text_447891', 'Gene': 'AC005082.12', 'topRSID': 'rs870476', 'p_SMR_multi': 2.45912e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1503741}, {'UUID': 'NDD_SMR_genes_all_update_text_1237815', 'Gene': 'AC005082.12', 'topRSID': 'rs1881200', 'p_SMR_multi': 2.619435e-06, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0138453}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.933 | Q11 | Are there any FANCC SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene FANCC that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FANCC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.159 | Q11 | Are there any MYLK-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Hippocampus samples tested there are no SNPs within the gene MYLK-AS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MYLK-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.425 | Q11 | Are there any ZMIZ1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZMIZ1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZMIZ1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1804 | Q11 | Are there any FAM190A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the FAM190A gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs1835524
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.66e-07; HEIDI: 1.5424e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM190A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_998616', 'Gene': 'FAM190A', 'topRSID': 'rs1835524', 'p_SMR_multi': 2.663993e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001542441}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.483 | Q11 | Are there any CLN5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CLN5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CLN5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1512 | Q11 | Are there any MAP2K3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MAP2K3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MAP2K3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.675 | Q11 | Are there any DUT SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene DUT that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DUT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1238 | Q11 | Are there any HEXA SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene HEXA that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HEXA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1873 | Q11 | Are there any RP11-757F18.5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex and Cerebellum samples tested there are no SNPs within the gene RP11-757F18.5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-757F18.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1299 | Q11 | Are there any SH2D4B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SH2D4B gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11186258
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.62e-08; HEIDI: 1.2587e-03
• rs34533074
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.23e-08; HEIDI: 9.0011e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SH2D4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572665', 'Gene': 'SH2D4B', 'topRSID': 'rs11186258', 'p_SMR_multi': 2.621326e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001258736}, {'UUID': 'NDD_SMR_genes_all_update_text_572663', 'Gene': 'SH2D4B', 'topRSID': 'rs34533074', 'p_SMR_multi': 4.234473e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00900114}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.453 | Q11 | Are there any PCDHB16 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene PCDHB16 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PCDHB16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.559 | Q11 | Are there any ZNF311 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF311 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs142403264
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.47e-07; HEIDI: 1.4085e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF311' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619798', 'Gene': 'ZNF311', 'topRSID': 'rs142403264', 'p_SMR_multi': 2.474527e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1408498}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.181 | Q11 | Are there any RP11-669E14.4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-669E14.4 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17661027
• Liver: Adjusted SMR multi-SNP P-value: 2.52e-11; HEIDI: -9.9990e+03
• rs575074983
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 6.39e-09; HEIDI: 2.0666e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-669E14.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1476425', 'Gene': 'RP11-669E14.4', 'topRSID': 'rs17661027', 'p_SMR_multi': 2.516234e-11, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242275', 'Gene': 'RP11-669E14.4', 'topRSID': 'rs575074983', 'p_SMR_multi': 6.392362e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002066643}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.396 | Q11 | Are there any SPATA2L SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SPATA2L that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SPATA2L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.584 | Q11 | Are there any RP11-270L13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-270L13.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-270L13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.995 | Q11 | Are there any RP11-508P1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-508P1.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-508P1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1707 | Q11 | Are there any OR51I2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene OR51I2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OR51I2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1285 | Q11 | Are there any THBS2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Hippocampus, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested there are no SNPs within the gene THBS2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'THBS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1645 | Q11 | Are there any KANSL1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the KANSL1 gene has 8 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Cortex: Adjusted SMR multi-SNP P-value: 7.96e-41; HEIDI: 4.3654e-16
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.49e-40; HEIDI: 3.4975e-13
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 6.59e-36; HEIDI: -9.9990e+03
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.96e-20; HEIDI: 7.1958e-09
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.27e-17; HEIDI: 1.5203e-08
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.68e-10; HEIDI: 9.3383e-05
• Spinalcord: Adjusted SMR multi-SNP P-value: 1.02e-07; HEIDI: 4.0308e-02
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.12e-07; HEIDI: 2.7744e-04
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.62e-20; HEIDI: 1.5062e-06
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.63e-11; HEIDI: 5.7655e-04
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.34e-10; HEIDI: 7.2617e-04
• Cortex: Adjusted SMR multi-SNP P-value: 1.58e-10; HEIDI: 3.1896e-08
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.46e-09; HEIDI: -9.9990e+03
• rs11012
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.60e-17; HEIDI: 2.1533e-06
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.80e-08; HEIDI: 5.0207e-01
• rs6503455
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 4.86e-15; HEIDI: 6.4047e-16
• rs8070723
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.85e-12; HEIDI: 2.3035e-08
• rs415430
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.72e-11; HEIDI: 2.7667e-03
• rs2074404
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.18e-10; HEIDI: 1.2868e-04
• rs11869096
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 1.03e-06; HEIDI: 2.4125e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KANSL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154397', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 7.964472999999991e-41, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.36535e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1041761', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.489683e-40, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.497522e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1444272', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 6.592123999999999e-36, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1579421', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.624344e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.506161e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_22217', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 9.962522e-20, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 7.195813e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1375929', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.2658660000000001e-17, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.520348e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1684934', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 2.1495340000000002e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.57845e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1646043', 'Gene': 'KANSL1', 'topRSID': 'rs11012', 'p_SMR_multi': 2.598531e-17, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.15328e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1336290', 'Gene': 'KANSL1', 'topRSID': 'rs6503455', 'p_SMR_multi': 4.855658e-15, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 6.404704e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1041765', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.966477e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.74918e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1041755', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.055914e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003041344}, {'UUID': 'NDD_SMR_genes_all_update_text_1041763', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.961778e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560883', 'Gene': 'KANSL1', 'topRSID': 'rs8070723', 'p_SMR_multi': 4.848303e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.303492e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1041762', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 6.347218e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041757', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 8.697504e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1616407}, {'UUID': 'NDD_SMR_genes_all_update_text_1041760', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 9.282511e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001248821}, {'UUID': 'NDD_SMR_genes_all_update_text_1194216', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.63123e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.0005765519}, {'UUID': 'NDD_SMR_genes_all_update_text_1041759', 'Gene': 'KANSL1', 'topRSID': 'rs415430', 'p_SMR_multi': 1.7176e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002766742}, {'UUID': 'NDD_SMR_genes_all_update_text_560884', 'Gene': 'KANSL1', 'topRSID': 'rs8070723', 'p_SMR_multi': 8.512009e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041768', 'Gene': 'KANSL1', 'topRSID': 'rs415430', 'p_SMR_multi': 1.08435e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01779159}, {'UUID': 'NDD_SMR_genes_all_update_text_1041756', 'Gene': 'KANSL1', 'topRSID': 'rs415430', 'p_SMR_multi': 1.093189e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007118905}, {'UUID': 'NDD_SMR_genes_all_update_text_1041754', 'Gene': 'KANSL1', 'topRSID': 'rs2074404', 'p_SMR_multi': 1.176205e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001286832}, {'UUID': 'NDD_SMR_genes_all_update_text_1041758', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.188747e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0004731884}, {'UUID': 'NDD_SMR_genes_all_update_text_1714155', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.339016e-10, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0007261717}, {'UUID': 'NDD_SMR_genes_all_update_text_1264981', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.57619e-10, 'Omic_tissue': 'Cortex', 'p_HEIDI': 3.189608e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_33471', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 3.683534e-10, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 9.338251e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1041769', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 4.408311e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1283702', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.458009e-09, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041767', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 4.579947e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041766', 'Gene': 'KANSL1', 'topRSID': 'rs17692129', 'p_SMR_multi': 7.931569e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041764', 'Gene': 'KANSL1', 'topRSID': 'rs11012', 'p_SMR_multi': 1.803964e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.5020692}, {'UUID': 'NDD_SMR_genes_all_update_text_30481', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.021386e-07, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 0.04030833}, {'UUID': 'NDD_SMR_genes_all_update_text_27912', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.117822e-07, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 0.0002774411}, {'UUID': 'NDD_SMR_genes_all_update_text_1489537', 'Gene': 'KANSL1', 'topRSID': 'rs11869096', 'p_SMR_multi': 1.028582e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.02412453}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.886 | Q11 | Are there any PRSS36 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the PRSS36 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55667375
• Cortex: Adjusted SMR multi-SNP P-value: 3.01e-08; HEIDI: 2.5847e-05
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.18e-06; HEIDI: 1.7796e-01
• rs78924645
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.08e-08; HEIDI: 1.8308e-06
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.76e-07; HEIDI: 6.0222e-05
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.38e-06; HEIDI: 2.2698e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRSS36' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140855', 'Gene': 'PRSS36', 'topRSID': 'rs55667375', 'p_SMR_multi': 3.010464e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.584743e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1435349', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 8.075668e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.830839e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1563819', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 2.756299e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.02217e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_20692', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 1.378272e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0002269768}, {'UUID': 'NDD_SMR_genes_all_update_text_485473', 'Gene': 'PRSS36', 'topRSID': 'rs55667375', 'p_SMR_multi': 2.181694e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1779642}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.827 | Q11 | Are there any CTD-2506J14.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTD-2506J14.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTD-2506J14.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1660 | Q11 | Are there any AC005336.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene AC005336.5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC005336.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.972 | Q11 | Are there any RP11-420K14.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Skeletal Muscle, Whole Brain and Cerebellum samples tested there are no SNPs within the gene RP11-420K14.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-420K14.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1049 | Q11 | Are there any AC012594.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AC012594.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC012594.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.671 | Q11 | Are there any KRTAP10-8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene KRTAP10-8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'KRTAP10-8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.145 | Q11 | Are there any ZBTB10 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZBTB10 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZBTB10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1518 | Q11 | Are there any RELB SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RELB that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RELB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1999 | Q11 | Are there any FMNL1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the FMNL1 gene has 3 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs393152
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.14e-16; HEIDI: 2.0912e-25
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.01e-15; HEIDI: 5.7561e-12
• rs1981997
• Cerebellum: Adjusted SMR multi-SNP P-value: 6.10e-15; HEIDI: 7.0256e-14
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 5.05e-14; HEIDI: 1.9366e-11
• rs17630064
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.24e-08; HEIDI: 6.3968e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FMNL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1444266', 'Gene': 'FMNL1', 'topRSID': 'rs393152', 'p_SMR_multi': 8.140853e-16, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.091241e-25}, {'UUID': 'NDD_SMR_genes_all_update_text_22214', 'Gene': 'FMNL1', 'topRSID': 'rs393152', 'p_SMR_multi': 2.005974e-15, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 5.756073e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1714145', 'Gene': 'FMNL1', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.099141e-15, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 7.025564e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1194207', 'Gene': 'FMNL1', 'topRSID': 'rs1981997', 'p_SMR_multi': 5.049675e-14, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.93655e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1041691', 'Gene': 'FMNL1', 'topRSID': 'rs17630064', 'p_SMR_multi': 7.240738e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06396753}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.871 | Q11 | Are there any HSD17B1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Tibial Nerve, Skeletal Muscle, Amygdala and Cerebellum samples tested there are no SNPs within the gene HSD17B1P1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HSD17B1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.427 | Q11 | Are there any SMC3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene SMC3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SMC3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.643 | Q11 | Are there any EPHB4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the EPHB4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs314320
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.07e-11; HEIDI: 1.9852e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EPHB4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495822', 'Gene': 'EPHB4', 'topRSID': 'rs314320', 'p_SMR_multi': 2.072844e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1985198}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1408 | Q11 | Are there any RP11-374A4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene RP11-374A4.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-374A4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.806 | Q11 | Are there any SOX9 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene SOX9 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SOX9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1067 | Q11 | Are there any VN1R1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Whole Blood and Whole Brain samples tested there are no SNPs within the gene VN1R1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'VN1R1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.622 | Q11 | Are there any RP11-669E14.4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-669E14.4 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs1981997
• Liver: Adjusted SMR multi-SNP P-value: 1.19e-17; HEIDI: 1.3578e-13 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-669E14.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1478186', 'Gene': 'RP11-669E14.4', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.188485e-17, 'Omic_tissue': 'Liver', 'p_HEIDI': 1.35783e-13}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.298 | Q11 | Are there any CCDC189 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CCDC189 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs8048448
• Cortex: Adjusted SMR multi-SNP P-value: 3.32e-08; HEIDI: 1.1412e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CCDC189' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140846', 'Gene': 'CCDC189', 'topRSID': 'rs8048448', 'p_SMR_multi': 3.320725e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.01141197}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.912 | Q11 | Are there any RP11-344B5.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-344B5.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-344B5.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.917 | Q11 | Are there any HSD3B7 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the HSD3B7 gene has 4 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs13708
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 4.21e-08; HEIDI: 3.5754e-02
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.64e-07; HEIDI: 9.3630e-02
• rs897986
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 5.76e-08; HEIDI: 5.7979e-09
• rs8060857
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.00e-08; HEIDI: 6.6883e-03
• rs4889606
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.67e-07; HEIDI: 3.7054e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HSD3B7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1370179', 'Gene': 'HSD3B7', 'topRSID': 'rs13708', 'p_SMR_multi': 4.214737e-08, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.03575398}, {'UUID': 'NDD_SMR_genes_all_update_text_1435342', 'Gene': 'HSD3B7', 'topRSID': 'rs897986', 'p_SMR_multi': 5.760116e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.797939e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_485447', 'Gene': 'HSD3B7', 'topRSID': 'rs8060857', 'p_SMR_multi': 7.997804e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.00668826}, {'UUID': 'NDD_SMR_genes_all_update_text_1241724', 'Gene': 'HSD3B7', 'topRSID': 'rs13708', 'p_SMR_multi': 7.637274e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.09362997}, {'UUID': 'NDD_SMR_genes_all_update_text_1563808', 'Gene': 'HSD3B7', 'topRSID': 'rs4889606', 'p_SMR_multi': 7.667319e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.705421e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1903 | Q11 | Are there any PTEN SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PTEN that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PTEN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.91 | Q11 | Are there any CTC-248O19.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTC-248O19.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTC-248O19.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.42 | Q11 | Are there any TRPM2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TRPM2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'TRPM2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1803 | Q11 | Are there any CCDC13 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene CCDC13 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CCDC13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1934 | Q11 | Are there any MTERFD3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MTERFD3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MTERFD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.134 | Q11 | Are there any HBD SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Cortex samples tested there are no SNPs within the gene HBD that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HBD' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1566 | Q11 | Are there any POP7 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene POP7 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'POP7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.977 | Q11 | Are there any KIF18B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene KIF18B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KIF18B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1070 | Q11 | Are there any RP11-792D21.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-792D21.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-792D21.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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