uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
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|---|---|---|---|---|---|---|---|---|
Q11.1856 | Q11 | Are there any CTD-2179L22.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene CTD-2179L22.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTD-2179L22.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1346 | Q11 | Are there any AL132709.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AL132709.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AL132709.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1831 | Q11 | Are there any COG1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene COG1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'COG1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.167 | Q11 | Are there any CTB-58E17.5 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene CTB-58E17.5 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTB-58E17.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.731 | Q11 | Are there any RP11-259G18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-259G18.1 gene has 15 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.37e-15; HEIDI: 1.8060e-06
• rs554899842
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.60e-13; HEIDI: 1.0861e-02
• rs112275277
• Cerebellum: Adjusted SMR multi-SNP P-value: 5.95e-13; HEIDI: -9.9990e+03
• rs4564621
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 3.44e-12; HEIDI: -9.9990e+03
• rs62057147
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.51e-10; HEIDI: -9.9990e+03
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.46e-08; HEIDI: 6.6811e-03
• rs17652520
• Cortex: Adjusted SMR multi-SNP P-value: 5.31e-10; HEIDI: -9.9990e+03
• rs111198951
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.73e-10; HEIDI: -9.9990e+03
• rs62061714
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 7.95e-10; HEIDI: -9.9990e+03
• rs1631850
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 9.65e-10; HEIDI: 4.6207e-01
• rs199531
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 6.66e-09; HEIDI: 1.2340e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-259G18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564788', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs2532233', 'p_SMR_multi': 4.366554e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.806015e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_491164', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs554899842', 'p_SMR_multi': 5.604857e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01086052}, {'UUID': 'NDD_SMR_genes_all_update_text_1710353', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs112275277', 'p_SMR_multi': 5.948505e-13, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1191175', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs4564621', 'p_SMR_multi': 3.444404e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1730068', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62057147', 'p_SMR_multi': 2.50639e-10, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262228', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs17652520', 'p_SMR_multi': 5.306636e-10, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491163', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs111198951', 'p_SMR_multi': 5.727347e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1328937', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62061714', 'p_SMR_multi': 7.947149e-10, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1281358', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs1631850', 'p_SMR_multi': 9.651509e-10, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.46207}, {'UUID': 'NDD_SMR_genes_all_update_text_1488143', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs199531', 'p_SMR_multi': 6.65777e-09, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.1234044}, {'UUID': 'NDD_SMR_genes_all_update_text_1594927', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs757055', 'p_SMR_multi': 7.618063e-09, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640225', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62057147', 'p_SMR_multi': 1.457128e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.00668111}, {'UUID': 'NDD_SMR_genes_all_update_text_1168838', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs62063281', 'p_SMR_multi': 1.741126e-08, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.04436433}, {'UUID': 'NDD_SMR_genes_all_update_text_1603779', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs112411928', 'p_SMR_multi': 3.789212e-08, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242280', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs575074983', 'p_SMR_multi': 4.231219e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0001553324}, {'UUID': 'NDD_SMR_genes_all_update_text_1462898', 'Gene': 'RP11-259G18.1', 'topRSID': 'rs199454', 'p_SMR_multi': 1.898892e-07, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.3843186}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.294 | Q11 | Are there any USP6NL SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the USP6NL gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12356673
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.39e-06; HEIDI: 1.2333e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'USP6NL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497347', 'Gene': 'USP6NL', 'topRSID': 'rs12356673', 'p_SMR_multi': 2.391135e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1233345}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1142 | Q11 | Are there any PAMR1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PAMR1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PAMR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1536 | Q11 | Are there any LPAR2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LPAR2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LPAR2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1897 | Q11 | Are there any CDH15 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle and Cerebellum samples tested there are no SNPs within the gene CDH15 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CDH15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1006 | Q11 | Are there any TJP1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TJP1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TJP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1421 | Q11 | Are there any NPIPP1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene NPIPP1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NPIPP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.785 | Q11 | Are there any LMAN1L SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Cortex samples tested there are no SNPs within the gene LMAN1L that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LMAN1L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.846 | Q11 | Are there any GPR125 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene GPR125 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GPR125' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.352 | Q11 | Are there any FAM57B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM57B gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11642399
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.64e-08; HEIDI: 6.9607e-02
• rs4788213
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.65e-07; HEIDI: 4.7978e-03
• rs7191849
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.99e-07; HEIDI: 1.1807e-01
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.13e-06; HEIDI: 1.5865e-01
• rs12447915
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.33e-06; HEIDI: 3.1314e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM57B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577429', 'Gene': 'FAM57B', 'topRSID': 'rs11642399', 'p_SMR_multi': 2.638529e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06960655}, {'UUID': 'NDD_SMR_genes_all_update_text_109463', 'Gene': 'FAM57B', 'topRSID': 'rs4788213', 'p_SMR_multi': 5.648017e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.004797759}, {'UUID': 'NDD_SMR_genes_all_update_text_577433', 'Gene': 'FAM57B', 'topRSID': 'rs7191849', 'p_SMR_multi': 9.988077e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1180695}, {'UUID': 'NDD_SMR_genes_all_update_text_1342780', 'Gene': 'FAM57B', 'topRSID': 'rs7191849', 'p_SMR_multi': 1.125747e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.1586474}, {'UUID': 'NDD_SMR_genes_all_update_text_577430', 'Gene': 'FAM57B', 'topRSID': 'rs12447915', 'p_SMR_multi': 1.328672e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3131449}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1945 | Q11 | Are there any COA5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Cortex, Hippocampus, Multi Ancestry Whole Brain, Whole Blood, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene COA5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'COA5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.577 | Q11 | Are there any CCDC51 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CCDC51 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CCDC51' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1923 | Q11 | Are there any MGC57346 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the MGC57346 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62056790
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-11; HEIDI: 9.9753e-05
• rs389217
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.49e-08; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MGC57346' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948857', 'Gene': 'MGC57346', 'topRSID': 'rs62056790', 'p_SMR_multi': 1.122792e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.975255e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_491084', 'Gene': 'MGC57346', 'topRSID': 'rs389217', 'p_SMR_multi': 5.4921e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1888 | Q11 | Are there any PRSS53 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the PRSS53 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs9923231
• Liver: Adjusted SMR multi-SNP P-value: 1.38e-07; HEIDI: 1.6492e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRSS53' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1476295', 'Gene': 'PRSS53', 'topRSID': 'rs9923231', 'p_SMR_multi': 1.382246e-07, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.001649207}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1470 | Q11 | Are there any MINPP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene MINPP1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MINPP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1818 | Q11 | Are there any AC009133.20 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC009133.20 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC009133.20' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1317 | Q11 | Are there any RP11-736N17.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Liver samples tested there are no SNPs within the gene RP11-736N17.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-736N17.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1501 | Q11 | Are there any TOMM40L SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TOMM40L gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs5082
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.40e-06; HEIDI: 9.0260e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TOMM40L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1490910', 'Gene': 'TOMM40L', 'topRSID': 'rs5082', 'p_SMR_multi': 1.395985e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.026045e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.464 | Q11 | Are there any FAM63B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM63B gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs395601
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.79e-07; HEIDI: 3.5623e-06
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.02e-07; HEIDI: 1.6916e-03
• rs2555357
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.36e-07; HEIDI: 1.1429e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM63B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500786', 'Gene': 'FAM63B', 'topRSID': 'rs395601', 'p_SMR_multi': 3.7851e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.562255e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_105565', 'Gene': 'FAM63B', 'topRSID': 'rs395601', 'p_SMR_multi': 5.017688e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001691641}, {'UUID': 'NDD_SMR_genes_all_update_text_646472', 'Gene': 'FAM63B', 'topRSID': 'rs2555357', 'p_SMR_multi': 5.360861e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001142865}, {'UUID': 'NDD_SMR_genes_all_update_text_646471', 'Gene': 'FAM63B', 'topRSID': 'rs395601', 'p_SMR_multi': 2.925908e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0005645899}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.381 | Q11 | Are there any LOC286094 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LOC286094 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'LOC286094' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1344 | Q11 | Are there any AC083843.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Liver samples tested there are no SNPs within the gene AC083843.3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC083843.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.337 | Q11 | Are there any MAPK6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MAPK6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MAPK6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1284 | Q11 | Are there any BTNL2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the BTNL2 gene has 11 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs116522341
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.68e-09; HEIDI: 2.2846e-05
• rs115303880
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.71e-09; HEIDI: 1.6082e-03
• rs112627226
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.28e-09; HEIDI: 2.4539e-01
• rs9268912
• Cortex: Adjusted SMR multi-SNP P-value: 1.77e-08; HEIDI: 4.8827e-04
• rs9271430
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.90e-08; HEIDI: 1.0256e-07
• rs17191234
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.57e-07; HEIDI: 2.2692e-02
• rs115625939
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.11e-07; HEIDI: 1.4872e-01
• rs743862
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.77e-07; HEIDI: 1.0016e-04
• rs28366340
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.59e-07; HEIDI: 3.3798e-01
• rs28366339
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.08e-06; HEIDI: 3.1267e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BTNL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621688', 'Gene': 'BTNL2', 'topRSID': 'rs116522341', 'p_SMR_multi': 2.681311e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.28461e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_621673', 'Gene': 'BTNL2', 'topRSID': 'rs115303880', 'p_SMR_multi': 2.707541e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001608231}, {'UUID': 'NDD_SMR_genes_all_update_text_621675', 'Gene': 'BTNL2', 'topRSID': 'rs115303880', 'p_SMR_multi': 3.365321e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00152662}, {'UUID': 'NDD_SMR_genes_all_update_text_621676', 'Gene': 'BTNL2', 'topRSID': 'rs115303880', 'p_SMR_multi': 3.597232e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007224479}, {'UUID': 'NDD_SMR_genes_all_update_text_621680', 'Gene': 'BTNL2', 'topRSID': 'rs112627226', 'p_SMR_multi': 8.283388e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2453855}, {'UUID': 'NDD_SMR_genes_all_update_text_1109083', 'Gene': 'BTNL2', 'topRSID': 'rs9268912', 'p_SMR_multi': 1.766397e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.0004882714}, {'UUID': 'NDD_SMR_genes_all_update_text_621707', 'Gene': 'BTNL2', 'topRSID': 'rs9271430', 'p_SMR_multi': 8.90255e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.025571e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_621708', 'Gene': 'BTNL2', 'topRSID': 'rs17191234', 'p_SMR_multi': 1.567343e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02269178}, {'UUID': 'NDD_SMR_genes_all_update_text_621709', 'Gene': 'BTNL2', 'topRSID': 'rs115625939', 'p_SMR_multi': 3.109153e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1487153}, {'UUID': 'NDD_SMR_genes_all_update_text_621710', 'Gene': 'BTNL2', 'topRSID': 'rs115625939', 'p_SMR_multi': 4.685914e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1239005}, {'UUID': 'NDD_SMR_genes_all_update_text_66180', 'Gene': 'BTNL2', 'topRSID': 'rs743862', 'p_SMR_multi': 7.772883e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001001581}, {'UUID': 'NDD_SMR_genes_all_update_text_621686', 'Gene': 'BTNL2', 'topRSID': 'rs28366340', 'p_SMR_multi': 8.587919e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3379752}, {'UUID': 'NDD_SMR_genes_all_update_text_621685', 'Gene': 'BTNL2', 'topRSID': 'rs28366339', 'p_SMR_multi': 1.077576e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.312675}, {'UUID': 'NDD_SMR_genes_all_update_text_621700', 'Gene': 'BTNL2', 'topRSID': 'rs532098', 'p_SMR_multi': 1.169206e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005595962}, {'UUID': 'NDD_SMR_genes_all_update_text_621682', 'Gene': 'BTNL2', 'topRSID': 'rs115303880', 'p_SMR_multi': 1.323332e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04378742}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1762 | Q11 | Are there any AQP12A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene AQP12A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AQP12A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1459 | Q11 | Are there any ZEB1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZEB1-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZEB1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.823 | Q11 | Are there any PVR SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PVR gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2301275
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.60e-11; HEIDI: 1.9234e-06
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.95e-09; HEIDI: 2.8924e-05
• rs11540084
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 7.95e-10; HEIDI: 3.1340e-11
• Cortex: Adjusted SMR multi-SNP P-value: 1.08e-08; HEIDI: 2.5132e-04
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.00e-07; HEIDI: 2.1382e-06
• rs79572806
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.20e-09; HEIDI: 6.9878e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PVR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203795', 'Gene': 'PVR', 'topRSID': 'rs2301275', 'p_SMR_multi': 1.598998e-11, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 1.923418e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1397643', 'Gene': 'PVR', 'topRSID': 'rs11540084', 'p_SMR_multi': 7.947475e-10, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.133981e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1503902', 'Gene': 'PVR', 'topRSID': 'rs79572806', 'p_SMR_multi': 7.19757e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.987784e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1343792', 'Gene': 'PVR', 'topRSID': 'rs2301275', 'p_SMR_multi': 9.947298e-09, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 2.892447e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1108028', 'Gene': 'PVR', 'topRSID': 'rs11540084', 'p_SMR_multi': 1.078395e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.0002513171}, {'UUID': 'NDD_SMR_genes_all_update_text_1611532', 'Gene': 'PVR', 'topRSID': 'rs11540084', 'p_SMR_multi': 4.995098e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.13819e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1114 | Q11 | Are there any FCRL4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FCRL4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FCRL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1524 | Q11 | Are there any CTGLF12P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Whole Blood and Whole Brain samples tested there are no SNPs within the gene CTGLF12P that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CTGLF12P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1941 | Q11 | Are there any COL6A5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene COL6A5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'COL6A5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1616 | Q11 | Are there any U2AF1L4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene U2AF1L4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'U2AF1L4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1898 | Q11 | Are there any SEC11C SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene SEC11C that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SEC11C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.918 | Q11 | Are there any TMEM175 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the TMEM175 gene has 1 SNP that is statistically significant in Lewy Body Dementia:
• rs11248059
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.88e-06; HEIDI: 6.0256e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TMEM175' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_932593', 'Gene': 'TMEM175', 'topRSID': 'rs11248059', 'p_SMR_multi': 2.884618e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06025584}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1930 | Q11 | Are there any JAZF1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the JAZF1-AS1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs73300665
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.61e-06; HEIDI: 4.8429e-03
• rs849336
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.37e-06; HEIDI: 1.2515e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'JAZF1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1198595', 'Gene': 'JAZF1-AS1', 'topRSID': 'rs73300665', 'p_SMR_multi': 1.608877e-06, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.004842932}, {'UUID': 'NDD_SMR_genes_all_update_text_584300', 'Gene': 'JAZF1-AS1', 'topRSID': 'rs849336', 'p_SMR_multi': 2.371217e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001251494}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1126 | Q11 | Are there any CCDC28B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CCDC28B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CCDC28B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.332 | Q11 | Are there any CARD17 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CARD17 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CARD17' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1036 | Q11 | Are there any SLC25A48 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SLC25A48 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SLC25A48' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.322 | Q11 | Are there any ZFP57 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Liver samples tested there are no SNPs within the gene ZFP57 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZFP57' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1531 | Q11 | Are there any RP11-23P13.7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene RP11-23P13.7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-23P13.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1360 | Q11 | Are there any CTC-523E23.5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene CTC-523E23.5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTC-523E23.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1734 | Q11 | Are there any KIAA0831 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene KIAA0831 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KIAA0831' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.170 | Q11 | Are there any AP001057.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AP001057.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AP001057.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.13 | Q11 | Are there any HS1BP3-IT1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene HS1BP3-IT1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HS1BP3-IT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1927 | Q11 | Are there any SERPINB8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SERPINB8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SERPINB8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.174 | Q11 | Are there any IMPA1P SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene IMPA1P that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IMPA1P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.656 | Q11 | Are there any YOD1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene YOD1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'YOD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1062 | Q11 | Are there any SLC39A13 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SLC39A13 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2071304
• Cortex: Adjusted SMR multi-SNP P-value: 2.19e-06; HEIDI: 5.7432e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLC39A13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1112424', 'Gene': 'SLC39A13', 'topRSID': 'rs2071304', 'p_SMR_multi': 2.194578e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.005743233}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.263 | Q11 | Are there any ZNF296 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF296 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs8100183
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.95e-09; HEIDI: 5.7896e-09 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF296' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1397649', 'Gene': 'ZNF296', 'topRSID': 'rs8100183', 'p_SMR_multi': 4.947535e-09, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.789577e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1611536', 'Gene': 'ZNF296', 'topRSID': 'rs8100183', 'p_SMR_multi': 2.663557e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0005450012}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1427 | Q11 | Are there any APBB2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene APBB2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'APBB2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1582 | Q11 | Are there any AC006026.13 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC006026.13 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC006026.13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.909 | Q11 | Are there any KANSL1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KANSL1-AS1 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs199447
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 8.64e-08; HEIDI: 4.1685e-04
• rs55974014
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.32e-07; HEIDI: 7.3855e-01
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 5.84e-07; HEIDI: 6.5146e-01
• Cortex: Adjusted SMR multi-SNP P-value: 2.10e-06; HEIDI: 6.6432e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.61e-06; HEIDI: 7.9177e-01
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.78e-06; HEIDI: 8.7931e-01
• rs1378358
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.99e-07; HEIDI: 4.3650e-01
• rs199456
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.90e-07; HEIDI: 2.1528e-01
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.02e-06; HEIDI: 3.4656e-01
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.09e-06; HEIDI: 9.0277e-02
• rs199533
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.55e-06; HEIDI: 5.5350e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KANSL1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203012', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199447', 'p_SMR_multi': 8.642094e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0004168492}, {'UUID': 'NDD_SMR_genes_all_update_text_1396750', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 3.316083e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.7385473}, {'UUID': 'NDD_SMR_genes_all_update_text_1610866', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1378358', 'p_SMR_multi': 3.990818e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4364977}, {'UUID': 'NDD_SMR_genes_all_update_text_1343155', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.840541e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.6514636}, {'UUID': 'NDD_SMR_genes_all_update_text_1652499', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199456', 'p_SMR_multi': 6.90175e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2152821}, {'UUID': 'NDD_SMR_genes_all_update_text_1502449', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.091459e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.09027697}, {'UUID': 'NDD_SMR_genes_all_update_text_1291761', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199456', 'p_SMR_multi': 2.024902e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.3465603}, {'UUID': 'NDD_SMR_genes_all_update_text_1247084', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.096707e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.6643203}, {'UUID': 'NDD_SMR_genes_all_update_text_1157200', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 2.550875e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.5535007}, {'UUID': 'NDD_SMR_genes_all_update_text_1717378', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.611147e-06, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.7917655}, {'UUID': 'NDD_SMR_genes_all_update_text_1584311', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.780259e-06, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.8793121}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.679 | Q11 | Are there any OR10B1P SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OR10B1P that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'OR10B1P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.261 | Q11 | Are there any AC007036.6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC007036.6 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC007036.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.851 | Q11 | Are there any RNU6-1011P SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RNU6-1011P that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RNU6-1011P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.874 | Q11 | Are there any OR1C1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene OR1C1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'OR1C1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1564 | Q11 | Are there any APCDD1L-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene APCDD1L-AS1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'APCDD1L-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.141 | Q11 | Are there any RP11-120K18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-120K18.3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11574631
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.87e-07; HEIDI: 1.0393e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-120K18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501485', 'Gene': 'RP11-120K18.3', 'topRSID': 'rs11574631', 'p_SMR_multi': 9.866759e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001039313}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.900 | Q11 | Are there any RNASEH2B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RNASEH2B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RNASEH2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1839 | Q11 | Are there any SAT2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SAT2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SAT2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.555 | Q11 | Are there any GAK SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the GAK gene has 19 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs11248057
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.49e-10; HEIDI: 1.1654e-06
• rs12651271
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.18e-09; HEIDI: 3.6193e-07
• rs11736451
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.08e-09; HEIDI: 3.7434e-07
• rs17165130
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.43e-08; HEIDI: 5.5897e-03
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.67e-06; HEIDI: 6.8654e-04
• rs6842808
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.04e-08; HEIDI: 4.6378e-11
• rs6837528
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.03e-08; HEIDI: 7.2156e-10
• rs3775122
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.04e-08; HEIDI: 7.6938e-06
• rs150789675
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.91e-08; HEIDI: 6.7378e-06
• rs10029038
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.06e-07; HEIDI: 4.7203e-05
• rs748483
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.21e-07; HEIDI: 3.1624e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GAK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_429832', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 1.488653e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.165356e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_429831', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 3.291044e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04156907}, {'UUID': 'NDD_SMR_genes_all_update_text_429829', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 3.218033e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001536991}, {'UUID': 'NDD_SMR_genes_all_update_text_996273', 'Gene': 'GAK', 'topRSID': 'rs12651271', 'p_SMR_multi': 6.180527e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.619298e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_429820', 'Gene': 'GAK', 'topRSID': 'rs11736451', 'p_SMR_multi': 9.08232e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.743439e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_429830', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 9.573748e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01181937}, {'UUID': 'NDD_SMR_genes_all_update_text_429812', 'Gene': 'GAK', 'topRSID': 'rs17165130', 'p_SMR_multi': 1.426772e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0055897}, {'UUID': 'NDD_SMR_genes_all_update_text_429835', 'Gene': 'GAK', 'topRSID': 'rs6842808', 'p_SMR_multi': 2.043111e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.637812e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_996257', 'Gene': 'GAK', 'topRSID': 'rs12651271', 'p_SMR_multi': 2.450581e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.538919e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_996272', 'Gene': 'GAK', 'topRSID': 'rs6837528', 'p_SMR_multi': 6.027489e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.215561e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_996274', 'Gene': 'GAK', 'topRSID': 'rs3775122', 'p_SMR_multi': 7.04387e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.693821e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_996276', 'Gene': 'GAK', 'topRSID': 'rs150789675', 'p_SMR_multi': 8.906629e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.737811e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_996271', 'Gene': 'GAK', 'topRSID': 'rs6837528', 'p_SMR_multi': 1.015136e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.211126e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_996280', 'Gene': 'GAK', 'topRSID': 'rs10029038', 'p_SMR_multi': 1.062379e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.720296e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_429806', 'Gene': 'GAK', 'topRSID': 'rs748483', 'p_SMR_multi': 1.205698e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.162437e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_996266', 'Gene': 'GAK', 'topRSID': 'rs3775130', 'p_SMR_multi': 1.482067e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.42586e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_429797', 'Gene': 'GAK', 'topRSID': 'rs3775119', 'p_SMR_multi': 1.873871e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.061519e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_996260', 'Gene': 'GAK', 'topRSID': 'rs60523283', 'p_SMR_multi': 2.036859e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.122358e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_429801', 'Gene': 'GAK', 'topRSID': 'rs6599388', 'p_SMR_multi': 2.502337e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.007638382}, {'UUID': 'NDD_SMR_genes_all_update_text_429834', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 6.950808e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.981594e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_429796', 'Gene': 'GAK', 'topRSID': 'rs73207791', 'p_SMR_multi': 7.411553e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.573178e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_429817', 'Gene': 'GAK', 'topRSID': 'rs3775127', 'p_SMR_multi': 9.004092e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0007304708}, {'UUID': 'NDD_SMR_genes_all_update_text_429819', 'Gene': 'GAK', 'topRSID': 'rs2279182', 'p_SMR_multi': 1.05747e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0008159028}, {'UUID': 'NDD_SMR_genes_all_update_text_429833', 'Gene': 'GAK', 'topRSID': 'rs2279181', 'p_SMR_multi': 1.115049e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.000622979}, {'UUID': 'NDD_SMR_genes_all_update_text_996279', 'Gene': 'GAK', 'topRSID': 'rs17165130', 'p_SMR_multi': 1.673132e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0006865394}, {'UUID': 'NDD_SMR_genes_all_update_text_1635860', 'Gene': 'GAK', 'topRSID': 'rs11248057', 'p_SMR_multi': 2.554893e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.05941108}, {'UUID': 'NDD_SMR_genes_all_update_text_996261', 'Gene': 'GAK', 'topRSID': 'rs73207790', 'p_SMR_multi': 2.637333e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.429762e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.323 | Q11 | Are there any RP11-798G7.8 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-798G7.8 gene has 6 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs12373139
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.35e-17; HEIDI: 5.0036e-08
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.12e-12; HEIDI: 9.7141e-04
• rs11012
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.15e-13; HEIDI: 8.2545e-02
• rs1635291
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 9.85e-12; HEIDI: 8.5742e-05
• rs7220988
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.97e-11; HEIDI: 8.2750e-09
• rs1981997
• Cerebellum: Adjusted SMR multi-SNP P-value: 5.99e-08; HEIDI: 3.6409e-03
• rs11869096
• Liver: Adjusted SMR multi-SNP P-value: 3.85e-07; HEIDI: 2.8696e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-798G7.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1375924', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.3497710000000001e-17, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 5.003598e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1646038', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs11012', 'p_SMR_multi': 1.149704e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.08254508}, {'UUID': 'NDD_SMR_genes_all_update_text_1336283', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs12373139', 'p_SMR_multi': 3.121197e-12, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.0009714135}, {'UUID': 'NDD_SMR_genes_all_update_text_1194211', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs1635291', 'p_SMR_multi': 9.845351e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 8.5742e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1684929', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs7220988', 'p_SMR_multi': 9.967724e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.274962e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1714150', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs1981997', 'p_SMR_multi': 5.992207e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.00364094}, {'UUID': 'NDD_SMR_genes_all_update_text_1478183', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs11869096', 'p_SMR_multi': 3.852944e-07, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.02869639}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1854 | Q11 | Are there any FAM66D SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene FAM66D that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'FAM66D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1235 | Q11 | Are there any ERCC8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ERCC8 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs162244
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.48e-06; HEIDI: 2.5539e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ERCC8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1556332', 'Gene': 'ERCC8', 'topRSID': 'rs162244', 'p_SMR_multi': 1.48002e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002553856}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1726 | Q11 | Are there any UNC13C SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Skeletal Muscle samples tested there are no SNPs within the gene UNC13C that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UNC13C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.564 | Q11 | Are there any SULT2A1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene SULT2A1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SULT2A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.142 | Q11 | Are there any ZNF646 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ZNF646 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7294
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.78e-07; HEIDI: 2.0237e-05
• rs4889530
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 9.95e-07; HEIDI: 1.4133e-07
• rs4468641
• Liver: Adjusted SMR multi-SNP P-value: 2.67e-06; HEIDI: 3.3658e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF646' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_974687', 'Gene': 'ZNF646', 'topRSID': 'rs7294', 'p_SMR_multi': 2.778268e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.023725e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1435346', 'Gene': 'ZNF646', 'topRSID': 'rs4889530', 'p_SMR_multi': 9.94886e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.413311e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1476294', 'Gene': 'ZNF646', 'topRSID': 'rs4468641', 'p_SMR_multi': 2.66612e-06, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.3365812}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1736 | Q11 | Are there any ARL17B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the ARL17B gene has 5 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Cortex: Adjusted SMR multi-SNP P-value: 4.47e-42; HEIDI: 3.2237e-33
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.06e-13; HEIDI: 2.5837e-12
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.07e-11; HEIDI: 3.7639e-07
• Spinalcord: Adjusted SMR multi-SNP P-value: 4.84e-11; HEIDI: 5.9388e-04
• rs7225002
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.72e-22; HEIDI: 3.0369e-16
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.48e-12; HEIDI: 1.8780e-05
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.82e-08; HEIDI: 8.7567e-10
• rs4792831
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.34e-09; HEIDI: -9.9990e+03
• Cortex: Adjusted SMR multi-SNP P-value: 2.28e-07; HEIDI: -9.9990e+03
• Liver: Adjusted SMR multi-SNP P-value: 2.43e-07; HEIDI: -9.9990e+03
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.37e-07; HEIDI: -9.9990e+03
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 4.35e-07; HEIDI: 5.5791e-08
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 5.64e-07; HEIDI: -9.9990e+03
• rs3785883
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.99e-06; HEIDI: 1.5278e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ARL17B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154399', 'Gene': 'ARL17B', 'topRSID': 'rs169201', 'p_SMR_multi': 4.4691469999999997e-42, 'Omic_tissue': 'Cortex', 'p_HEIDI': 3.22368e-33}, {'UUID': 'NDD_SMR_genes_all_update_text_22219', 'Gene': 'ARL17B', 'topRSID': 'rs7225002', 'p_SMR_multi': 9.720874000000001e-22, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 3.036878e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_27914', 'Gene': 'ARL17B', 'topRSID': 'rs169201', 'p_SMR_multi': 2.063039e-13, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 2.583683e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1579427', 'Gene': 'ARL17B', 'topRSID': 'rs17692129', 'p_SMR_multi': 6.484325e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.878002e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_33473', 'Gene': 'ARL17B', 'topRSID': 'rs169201', 'p_SMR_multi': 3.065033e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 3.763938e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_30483', 'Gene': 'ARL17B', 'topRSID': 'rs169201', 'p_SMR_multi': 4.837238e-11, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 0.0005938816}, {'UUID': 'NDD_SMR_genes_all_update_text_1375933', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 1.338852e-09, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1646049', 'Gene': 'ARL17B', 'topRSID': 'rs17692129', 'p_SMR_multi': 3.821644e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.75672e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1264986', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 2.279116e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1478190', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 2.430902e-07, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1283707', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 3.370548e-07, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1732399', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 4.354531e-07, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 5.579067e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1596826', 'Gene': 'ARL17B', 'topRSID': 'rs4792831', 'p_SMR_multi': 5.641074e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1336295', 'Gene': 'ARL17B', 'topRSID': 'rs3785883', 'p_SMR_multi': 1.990803e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.0001527845}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.537 | Q11 | Are there any NEFL SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Cortex and Whole Blood samples tested there are no SNPs within the gene NEFL that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'NEFL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.227 | Q11 | Are there any C16orf54 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene C16orf54 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C16orf54' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.730 | Q11 | Are there any SNRPF SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SNRPF that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SNRPF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.793 | Q11 | Are there any APOBEC2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene APOBEC2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOBEC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1718 | Q11 | Are there any THUMPD3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene THUMPD3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'THUMPD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.994 | Q11 | Are there any SMPD4P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Hippocampus, Anterior Cingulate Cortex BA24, Whole Blood, Whole Brain and Cerebellum samples tested there are no SNPs within the gene SMPD4P1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SMPD4P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.415 | Q11 | Are there any FAM83A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene FAM83A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM83A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.329 | Q11 | Are there any RASEF SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RASEF that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RASEF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1098 | Q11 | Are there any CDK2AP2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Liver and Whole Blood samples tested there are no SNPs within the gene CDK2AP2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CDK2AP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.303 | Q11 | Are there any PRR18 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene PRR18 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRR18' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1259 | Q11 | Are there any RAB1B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RAB1B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RAB1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1996 | Q11 | Are there any C7orf59 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C7orf59 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11771139
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.98e-13; HEIDI: 8.9139e-06
• rs60458236
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.31e-09; HEIDI: 7.8573e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C7orf59' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585977', 'Gene': 'C7orf59', 'topRSID': 'rs11771139', 'p_SMR_multi': 3.977226e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.913888e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_74040', 'Gene': 'C7orf59', 'topRSID': 'rs60458236', 'p_SMR_multi': 3.313887e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.857328e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.26 | Q11 | Are there any RP11-638I2.10 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-638I2.10 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-638I2.10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1860 | Q11 | Are there any ADORA2B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ADORA2B gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs1045599
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.44e-06; HEIDI: 1.1966e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ADORA2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1435715', 'Gene': 'ADORA2B', 'topRSID': 'rs1045599', 'p_SMR_multi': 2.440225e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.000119655}, {'UUID': 'NDD_SMR_genes_all_update_text_1370421', 'Gene': 'ADORA2B', 'topRSID': 'rs1045599', 'p_SMR_multi': 2.729232e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0173546}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.721 | Q11 | Are there any LLGL1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LLGL1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2290507
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.18e-06; HEIDI: 2.5999e-01
• rs57808902
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.93e-06; HEIDI: 2.5009e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LLGL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589834', 'Gene': 'LLGL1', 'topRSID': 'rs2290507', 'p_SMR_multi': 1.175945e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2599892}, {'UUID': 'NDD_SMR_genes_all_update_text_113816', 'Gene': 'LLGL1', 'topRSID': 'rs57808902', 'p_SMR_multi': 1.930696e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2500914}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.996 | Q11 | Are there any LRRC37A5P SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene LRRC37A5P that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC37A5P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.196 | Q11 | Are there any RP11-495P10.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-495P10.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-495P10.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.446 | Q11 | Are there any AC064834.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Frontal Cortex, Prefrontal Cortex and Cortex samples tested there are no SNPs within the gene AC064834.3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC064834.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.579 | Q11 | Are there any RP11-428K3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene RP11-428K3.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-428K3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.955 | Q11 | Are there any ZKSCAN3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZKSCAN3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs213230
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.75e-06; HEIDI: 1.0278e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZKSCAN3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494675', 'Gene': 'ZKSCAN3', 'topRSID': 'rs213230', 'p_SMR_multi': 1.752465e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01027817}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.509 | Q11 | Are there any ASTL SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ASTL that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ASTL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.612 | Q11 | Are there any MTUS2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Liver samples tested there are no SNPs within the gene MTUS2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MTUS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1864 | Q11 | Are there any C9orf172 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle samples tested there are no SNPs within the gene C9orf172 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C9orf172' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1725 | Q11 | Are there any NFIL3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene NFIL3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NFIL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1885 | Q11 | Are there any APOC2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APOC2 gene has 9 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs5120
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.28e-24; HEIDI: 2.5724e-19
• rs2288911
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.65e-22; HEIDI: 3.1246e-16
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.95e-10; HEIDI: 2.2261e-07
• rs7252480
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.74e-11; HEIDI: 3.0708e-12
• rs11669173
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.21e-10; HEIDI: 2.9404e-06
• rs11878597
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.65e-10; HEIDI: 1.4794e-04
• rs12460352
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.99e-10; HEIDI: 1.0712e-10
• rs9304644
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.58e-08; HEIDI: 1.2695e-01
• rs204474
• Cortex: Adjusted SMR multi-SNP P-value: 3.60e-08; HEIDI: 1.2319e-03
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.64e-08; HEIDI: 5.6776e-04
• rs35193317
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.76e-06; HEIDI: 3.0795e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637437', 'Gene': 'APOC2', 'topRSID': 'rs5120', 'p_SMR_multi': 1.276397e-24, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.572368e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_637436', 'Gene': 'APOC2', 'topRSID': 'rs5120', 'p_SMR_multi': 1.441782e-24, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.111027e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_122470', 'Gene': 'APOC2', 'topRSID': 'rs2288911', 'p_SMR_multi': 7.649241e-22, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.124611e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_122469', 'Gene': 'APOC2', 'topRSID': 'rs2288911', 'p_SMR_multi': 3.126429e-21, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.55844e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_637438', 'Gene': 'APOC2', 'topRSID': 'rs7252480', 'p_SMR_multi': 4.737046e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.070771e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1717664', 'Gene': 'APOC2', 'topRSID': 'rs11669173', 'p_SMR_multi': 1.212744e-10, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 2.940443e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1584547', 'Gene': 'APOC2', 'topRSID': 'rs11878597', 'p_SMR_multi': 1.648401e-10, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.0001479393}, {'UUID': 'NDD_SMR_genes_all_update_text_1268425', 'Gene': 'APOC2', 'topRSID': 'rs2288911', 'p_SMR_multi': 1.950726e-10, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 2.226071e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_637439', 'Gene': 'APOC2', 'topRSID': 'rs12460352', 'p_SMR_multi': 1.990085e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.071247e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1203800', 'Gene': 'APOC2', 'topRSID': 'rs9304644', 'p_SMR_multi': 2.581525e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.1269466}, {'UUID': 'NDD_SMR_genes_all_update_text_1108031', 'Gene': 'APOC2', 'topRSID': 'rs204474', 'p_SMR_multi': 3.59541e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.001231871}, {'UUID': 'NDD_SMR_genes_all_update_text_24771', 'Gene': 'APOC2', 'topRSID': 'rs204474', 'p_SMR_multi': 3.63692e-08, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 0.0005677596}, {'UUID': 'NDD_SMR_genes_all_update_text_1690532', 'Gene': 'APOC2', 'topRSID': 'rs35193317', 'p_SMR_multi': 1.755952e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0003079511}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.853 | Q11 | Are there any C9orf153 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene C9orf153 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C9orf153' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.4 | Q11 | Are there any TMEM88B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TMEM88B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TMEM88B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1569 | Q11 | Are there any FAM213A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM213A gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs10788630
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.47e-10; HEIDI: 7.6689e-03
• rs66586255
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.27e-09; HEIDI: 7.5934e-03
• rs1870142
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.74e-07; HEIDI: 1.0905e-01
• rs4934147
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.60e-06; HEIDI: 1.1640e-06
• rs4258322
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.12e-06; HEIDI: 1.6199e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM213A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497628', 'Gene': 'FAM213A', 'topRSID': 'rs10788630', 'p_SMR_multi': 4.471628e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007668921}, {'UUID': 'NDD_SMR_genes_all_update_text_572643', 'Gene': 'FAM213A', 'topRSID': 'rs66586255', 'p_SMR_multi': 3.268222e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007593445}, {'UUID': 'NDD_SMR_genes_all_update_text_85777', 'Gene': 'FAM213A', 'topRSID': 'rs1870142', 'p_SMR_multi': 1.735328e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1090525}, {'UUID': 'NDD_SMR_genes_all_update_text_1393824', 'Gene': 'FAM213A', 'topRSID': 'rs4934147', 'p_SMR_multi': 1.601714e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.163999e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_572642', 'Gene': 'FAM213A', 'topRSID': 'rs4258322', 'p_SMR_multi': 2.115793e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1619914}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1461 | Q11 | Are there any BTD SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene BTD that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'BTD' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.473 | Q11 | Are there any STYX SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the STYX gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs77690283
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 8.21e-08; HEIDI: 5.8075e-03
• rs12435056
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.58e-06; HEIDI: 1.4535e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'STYX' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1342185', 'Gene': 'STYX', 'topRSID': 'rs77690283', 'p_SMR_multi': 8.214654e-08, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.005807537}, {'UUID': 'NDD_SMR_genes_all_update_text_1500187', 'Gene': 'STYX', 'topRSID': 'rs12435056', 'p_SMR_multi': 1.582742e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.45355e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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