uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
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|---|---|---|---|---|---|---|---|---|
Q11.325 | Q11 | Are there any GALNT16 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene GALNT16 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GALNT16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.6 | Q11 | Are there any GUCY2G SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GUCY2G that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'GUCY2G' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.225 | Q11 | Are there any CTSW SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Hypothalamus and Liver samples tested there are no SNPs within the gene CTSW that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CTSW' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1376 | Q11 | Are there any ACOT13 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ACOT13 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ACOT13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.553 | Q11 | Are there any SDHCP2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene SDHCP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SDHCP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.231 | Q11 | Are there any NPIPA9 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia and Cortex samples tested there are no SNPs within the gene NPIPA9 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NPIPA9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.40 | Q11 | Are there any FCRLA SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene FCRLA that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FCRLA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.548 | Q11 | Are there any ZSWIM7 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ZSWIM7 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1860643
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.55e-07; HEIDI: 2.3787e-01
• rs2535614
• Cortex: Adjusted SMR multi-SNP P-value: 2.31e-06; HEIDI: 1.8146e-01
• rs1045599
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.90e-06; HEIDI: 4.2928e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZSWIM7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1640053', 'Gene': 'ZSWIM7', 'topRSID': 'rs1860643', 'p_SMR_multi': 6.546399e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2378725}, {'UUID': 'NDD_SMR_genes_all_update_text_1147084', 'Gene': 'ZSWIM7', 'topRSID': 'rs2535614', 'p_SMR_multi': 2.313541e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.1814649}, {'UUID': 'NDD_SMR_genes_all_update_text_1370422', 'Gene': 'ZSWIM7', 'topRSID': 'rs1045599', 'p_SMR_multi': 2.902395e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0429278}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.245 | Q11 | Are there any SCN2B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene SCN2B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SCN2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.905 | Q11 | Are there any CNOT11 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CNOT11 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CNOT11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1429 | Q11 | Are there any RP11-6L6.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Liver, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-6L6.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-6L6.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.139 | Q11 | Are there any BRUNOL4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BRUNOL4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'BRUNOL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1191 | Q11 | Are there any CTC-325J23.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTC-325J23.3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTC-325J23.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1757 | Q11 | Are there any MMP2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene MMP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MMP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1573 | Q11 | Are there any RP11-1028N23.4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-1028N23.4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-1028N23.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1443 | Q11 | Are there any AC004899.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Hippocampus samples tested there are no SNPs within the gene AC004899.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC004899.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.836 | Q11 | Are there any ARHGAP8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ARHGAP8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ARHGAP8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.451 | Q11 | Are there any RPS26P8 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RPS26P8 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs1981997
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 8.37e-21; HEIDI: 1.3981e-18 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RPS26P8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1336287', 'Gene': 'RPS26P8', 'topRSID': 'rs1981997', 'p_SMR_multi': 8.372689e-21, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.398096e-18}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.849 | Q11 | Are there any CARMIL1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene CARMIL1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CARMIL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1087 | Q11 | Are there any BIN1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the BIN1 gene has 16 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs11682128
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.63e-38; HEIDI: 1.5319e-10
• rs58402148
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.41e-31; HEIDI: 3.9999e-37
• rs6720234
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.82e-18; HEIDI: 3.6874e-32
• rs10194375
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.38e-17; HEIDI: 9.9266e-13
• rs730471
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.12e-16; HEIDI: 3.0501e-22
• rs72846701
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.98e-15; HEIDI: 5.8397e-11
• rs10929008
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.35e-14; HEIDI: 2.8156e-18
• rs11694743
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.01e-14; HEIDI: 3.8216e-16
• rs934826
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.86e-14; HEIDI: 7.9714e-11
• rs13425623
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.27e-12; HEIDI: 3.1797e-15
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BIN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1491965', 'Gene': 'BIN1', 'topRSID': 'rs11682128', 'p_SMR_multi': 4.6304359999999996e-38, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.531931e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_631119', 'Gene': 'BIN1', 'topRSID': 'rs58402148', 'p_SMR_multi': 2.405281e-31, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.999879e-37}, {'UUID': 'NDD_SMR_genes_all_update_text_631125', 'Gene': 'BIN1', 'topRSID': 'rs6720234', 'p_SMR_multi': 5.817928e-18, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.687446e-32}, {'UUID': 'NDD_SMR_genes_all_update_text_631121', 'Gene': 'BIN1', 'topRSID': 'rs10194375', 'p_SMR_multi': 8.381006e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.926564e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_46339', 'Gene': 'BIN1', 'topRSID': 'rs730471', 'p_SMR_multi': 2.124617e-16, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.050073e-22}, {'UUID': 'NDD_SMR_genes_all_update_text_46338', 'Gene': 'BIN1', 'topRSID': 'rs72846701', 'p_SMR_multi': 3.976383e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.839736e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_46341', 'Gene': 'BIN1', 'topRSID': 'rs10929008', 'p_SMR_multi': 1.352902e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.815601e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1647997', 'Gene': 'BIN1', 'topRSID': 'rs11694743', 'p_SMR_multi': 2.013386e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.821633e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_631116', 'Gene': 'BIN1', 'topRSID': 'rs934826', 'p_SMR_multi': 6.85872e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.971364e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_631118', 'Gene': 'BIN1', 'topRSID': 'rs13425623', 'p_SMR_multi': 3.271333e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.179737e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_631123', 'Gene': 'BIN1', 'topRSID': 'rs34212842', 'p_SMR_multi': 1.911343e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.215511999999999e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_631124', 'Gene': 'BIN1', 'topRSID': 'rs11682128', 'p_SMR_multi': 2.097571e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.875468e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1390118', 'Gene': 'BIN1', 'topRSID': 'rs62158731', 'p_SMR_multi': 1.968759e-10, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.46745e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_631120', 'Gene': 'BIN1', 'topRSID': 'rs4663094', 'p_SMR_multi': 8.796913e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.1778030000000005e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1686596', 'Gene': 'BIN1', 'topRSID': 'rs62158731', 'p_SMR_multi': 1.637274e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.114888e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1171776', 'Gene': 'BIN1', 'topRSID': 'rs4663100', 'p_SMR_multi': 2.3819e-08, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.102427e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_486', 'Gene': 'BIN1', 'topRSID': 'rs7559175', 'p_SMR_multi': 2.649478e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 2.387742e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_46334', 'Gene': 'BIN1', 'topRSID': 'rs1060743', 'p_SMR_multi': 3.297688e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001531831}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1420 | Q11 | Are there any LPCAT1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LPCAT1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LPCAT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1154 | Q11 | Are there any RP3-467N11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene RP3-467N11.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP3-467N11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1826 | Q11 | Are there any SNURF SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene SNURF that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SNURF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.588 | Q11 | Are there any AC091132.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the AC091132.1 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs1635291
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.49e-10; HEIDI: 1.1310e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC091132.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1714148', 'Gene': 'AC091132.1', 'topRSID': 'rs1635291', 'p_SMR_multi': 9.493124e-10, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0001130954}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1892 | Q11 | Are there any RP11-669E14.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-669E14.4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs17661027
• Liver: Adjusted SMR multi-SNP P-value: 2.36e-06; HEIDI: -9.9990e+03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-669E14.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1466644', 'Gene': 'RP11-669E14.4', 'topRSID': 'rs17661027', 'p_SMR_multi': 2.358863e-06, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1970 | Q11 | Are there any PRKD1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PRKD1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PRKD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.668 | Q11 | Are there any AC021860.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene AC021860.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC021860.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.442 | Q11 | Are there any CTB-52I2.4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTB-52I2.4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTB-52I2.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1857 | Q11 | Are there any TREML2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREML2 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs3800342
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.21e-10; HEIDI: 7.7429e-04
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.74e-10; HEIDI: 1.4253e-02
• rs9471495
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.86e-08; HEIDI: 5.4788e-02
• rs2006080
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.08e-06; HEIDI: 1.1589e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREML2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_67040', 'Gene': 'TREML2', 'topRSID': 'rs3800342', 'p_SMR_multi': 1.208504e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0007742865}, {'UUID': 'NDD_SMR_genes_all_update_text_622647', 'Gene': 'TREML2', 'topRSID': 'rs3800342', 'p_SMR_multi': 1.735689e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01425278}, {'UUID': 'NDD_SMR_genes_all_update_text_1494869', 'Gene': 'TREML2', 'topRSID': 'rs9471495', 'p_SMR_multi': 3.856316e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05478847}, {'UUID': 'NDD_SMR_genes_all_update_text_67042', 'Gene': 'TREML2', 'topRSID': 'rs2006080', 'p_SMR_multi': 2.079623e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.158931e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.382 | Q11 | Are there any HSPBAP1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene HSPBAP1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'HSPBAP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1478 | Q11 | Are there any ZNF230 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene ZNF230 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZNF230' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.974 | Q11 | Are there any CRHR1-IT1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CRHR1-IT1 gene has 18 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2696532
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.78e-15; HEIDI: -9.9990e+03
• rs62055888
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 7.95e-15; HEIDI: -9.9990e+03
• rs62056913
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.70e-15; HEIDI: -9.9990e+03
• rs4564621
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 9.33e-15; HEIDI: -9.9990e+03
• rs62056905
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.26e-12; HEIDI: 8.0630e-01
• rs9468
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 7.60e-12; HEIDI: -9.9990e+03
• rs56040418
• Hippocampus: Adjusted SMR multi-SNP P-value: 9.21e-12; HEIDI: 9.2065e-01
• rs62063281
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.26e-11; HEIDI: 1.1322e-02
• rs77692262
• Cortex: Adjusted SMR multi-SNP P-value: 2.30e-11; HEIDI: -9.9990e+03
• rs4630591
• Hypothalamus: Adjusted SMR multi-SNP P-value: 2.35e-11; HEIDI: 5.3332e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CRHR1-IT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1679564', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs2696532', 'p_SMR_multi': 6.780794e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1370542', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62055888', 'p_SMR_multi': 7.950759e-15, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1435915', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62056913', 'p_SMR_multi': 8.701754e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1328930', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs4564621', 'p_SMR_multi': 9.334656e-15, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1281352', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62056905', 'p_SMR_multi': 3.261216e-12, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.8062952}, {'UUID': 'NDD_SMR_genes_all_update_text_1730062', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs9468', 'p_SMR_multi': 7.595442e-12, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1386990', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs56040418', 'p_SMR_multi': 9.214326e-12, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.9206501}, {'UUID': 'NDD_SMR_genes_all_update_text_1594922', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62063281', 'p_SMR_multi': 1.257225e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.01132221}, {'UUID': 'NDD_SMR_genes_all_update_text_1262223', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs77692262', 'p_SMR_multi': 2.304173e-11, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1462892', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs4630591', 'p_SMR_multi': 2.353776e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.5333156}, {'UUID': 'NDD_SMR_genes_all_update_text_1168834', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs34739559', 'p_SMR_multi': 4.55857e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.9601482}, {'UUID': 'NDD_SMR_genes_all_update_text_1603775', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs17650860', 'p_SMR_multi': 8.810692e-11, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1488138', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs112560196', 'p_SMR_multi': 9.91348e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1451662', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62061822', 'p_SMR_multi': 1.671854e-10, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640219', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62057067', 'p_SMR_multi': 1.992962e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 6.349835e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1242269', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs567299266', 'p_SMR_multi': 5.865565e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.004013437}, {'UUID': 'NDD_SMR_genes_all_update_text_1564782', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs112560196', 'p_SMR_multi': 3.311276e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0005865786}, {'UUID': 'NDD_SMR_genes_all_update_text_1191169', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs17652520', 'p_SMR_multi': 1.471046e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.1452017}, {'UUID': 'NDD_SMR_genes_all_update_text_1710347', 'Gene': 'CRHR1-IT1', 'topRSID': 'rs62055932', 'p_SMR_multi': 3.486499e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.4094546}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1210 | Q11 | Are there any RP11-420K14.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Skeletal Muscle, Whole Brain and Cerebellum samples tested there are no SNPs within the gene RP11-420K14.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-420K14.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.318 | Q11 | Are there any RAB7L1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RAB7L1 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs708723
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.66e-07; HEIDI: 1.1436e-02
• rs7522056
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.29e-07; HEIDI: 5.8560e-02
• rs708725
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.35e-06; HEIDI: 1.0553e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAB7L1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1428778', 'Gene': 'RAB7L1', 'topRSID': 'rs708723', 'p_SMR_multi': 2.655054e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.01143551}, {'UUID': 'NDD_SMR_genes_all_update_text_1553467', 'Gene': 'RAB7L1', 'topRSID': 'rs7522056', 'p_SMR_multi': 7.294008e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05855961}, {'UUID': 'NDD_SMR_genes_all_update_text_944675', 'Gene': 'RAB7L1', 'topRSID': 'rs708725', 'p_SMR_multi': 2.346266e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.055343e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.698 | Q11 | Are there any RGP1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene RGP1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RGP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1505 | Q11 | Are there any CAMTA2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CAMTA2 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs113536807
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.03e-09; HEIDI: 1.5736e-04
• rs8075365
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.81e-08; HEIDI: 1.0072e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CAMTA2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589033', 'Gene': 'CAMTA2', 'topRSID': 'rs113536807', 'p_SMR_multi': 1.031505e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000157363}, {'UUID': 'NDD_SMR_genes_all_update_text_1501919', 'Gene': 'CAMTA2', 'topRSID': 'rs8075365', 'p_SMR_multi': 7.813981e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.007217e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.430 | Q11 | Are there any OR8B4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OR8B4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'OR8B4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.601 | Q11 | Are there any EIF3J SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene EIF3J that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'EIF3J' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1964 | Q11 | Are there any ZNF45 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF45 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs108775
• Cortex: Adjusted SMR multi-SNP P-value: 2.33e-06; HEIDI: 1.3960e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF45' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1108017', 'Gene': 'ZNF45', 'topRSID': 'rs108775', 'p_SMR_multi': 2.330158e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.1396048}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.629 | Q11 | Are there any C21orf56 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C21orf56 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C21orf56' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1170 | Q11 | Are there any IER2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene IER2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'IER2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1254 | Q11 | Are there any TRIP13 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TRIP13 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIP13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.230 | Q11 | Are there any ATOH7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Liver samples tested there are no SNPs within the gene ATOH7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ATOH7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1180 | Q11 | Are there any PILRA SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PILRA gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2005763
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.30e-09; HEIDI: 6.9159e-05
• rs10085549
• Cortex: Adjusted SMR multi-SNP P-value: 1.64e-08; HEIDI: 3.4693e-03
• rs7786844
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.83e-08; HEIDI: 1.5732e-02
• rs61735533
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.11e-07; HEIDI: 1.7870e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PILRA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495807', 'Gene': 'PILRA', 'topRSID': 'rs2005763', 'p_SMR_multi': 2.304559e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.915895e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1105976', 'Gene': 'PILRA', 'topRSID': 'rs10085549', 'p_SMR_multi': 1.635262e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.003469287}, {'UUID': 'NDD_SMR_genes_all_update_text_1392629', 'Gene': 'PILRA', 'topRSID': 'rs7786844', 'p_SMR_multi': 4.833455e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.01573198}, {'UUID': 'NDD_SMR_genes_all_update_text_1340322', 'Gene': 'PILRA', 'topRSID': 'rs61735533', 'p_SMR_multi': 9.106531e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.1786957}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1332 | Q11 | Are there any CEP350 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CEP350 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CEP350' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1587 | Q11 | Are there any CXCL10 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CXCL10 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CXCL10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.69 | Q11 | Are there any ANKRD18CP SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Tibial Nerve, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ANKRD18CP that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ANKRD18CP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.25 | Q11 | Are there any RNF40 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RNF40 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17880887
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.08e-07; HEIDI: 1.0562e-07
• rs28853644
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.33e-06; HEIDI: 2.6092e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RNF40' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563803', 'Gene': 'RNF40', 'topRSID': 'rs17880887', 'p_SMR_multi': 8.079207e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.05622e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1435339', 'Gene': 'RNF40', 'topRSID': 'rs28853644', 'p_SMR_multi': 1.331406e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.000260919}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.147 | Q11 | Are there any ING1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ING1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ING1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.542 | Q11 | Are there any DOC2A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the DOC2A gene has 14 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs12921753
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.58e-12; HEIDI: 3.4417e-01
• rs4788213
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.71e-08; HEIDI: 6.8409e-02
• rs12596543
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.06e-08; HEIDI: 2.6646e-01
• rs11642740
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.62e-08; HEIDI: 4.7534e-01
• rs11863174
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.28e-08; HEIDI: 2.4246e-01
• rs10871451
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.53e-08; HEIDI: 3.9034e-04
• rs12325400
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.99e-08; HEIDI: 1.9705e-03
• rs12933575
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.10e-07; HEIDI: 9.1276e-02
• rs8060511
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.06e-07; HEIDI: 1.9122e-04
• rs12928610
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.45e-07; HEIDI: 1.8016e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DOC2A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577418', 'Gene': 'DOC2A', 'topRSID': 'rs12921753', 'p_SMR_multi': 5.575261e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3441697}, {'UUID': 'NDD_SMR_genes_all_update_text_577427', 'Gene': 'DOC2A', 'topRSID': 'rs4788213', 'p_SMR_multi': 1.713335e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06840859}, {'UUID': 'NDD_SMR_genes_all_update_text_577419', 'Gene': 'DOC2A', 'topRSID': 'rs12596543', 'p_SMR_multi': 2.058138e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2664604}, {'UUID': 'NDD_SMR_genes_all_update_text_577420', 'Gene': 'DOC2A', 'topRSID': 'rs11642740', 'p_SMR_multi': 3.619166e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4753392}, {'UUID': 'NDD_SMR_genes_all_update_text_577424', 'Gene': 'DOC2A', 'topRSID': 'rs11863174', 'p_SMR_multi': 4.279783e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2424647}, {'UUID': 'NDD_SMR_genes_all_update_text_109454', 'Gene': 'DOC2A', 'topRSID': 'rs10871451', 'p_SMR_multi': 7.531563e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.000390338}, {'UUID': 'NDD_SMR_genes_all_update_text_109456', 'Gene': 'DOC2A', 'topRSID': 'rs12325400', 'p_SMR_multi': 9.99089e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001970497}, {'UUID': 'NDD_SMR_genes_all_update_text_577421', 'Gene': 'DOC2A', 'topRSID': 'rs12933575', 'p_SMR_multi': 1.100408e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.09127554}, {'UUID': 'NDD_SMR_genes_all_update_text_109462', 'Gene': 'DOC2A', 'topRSID': 'rs8060511', 'p_SMR_multi': 2.060537e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001912192}, {'UUID': 'NDD_SMR_genes_all_update_text_109452', 'Gene': 'DOC2A', 'topRSID': 'rs12928610', 'p_SMR_multi': 2.452342e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01801584}, {'UUID': 'NDD_SMR_genes_all_update_text_577425', 'Gene': 'DOC2A', 'topRSID': 'rs11642612', 'p_SMR_multi': 3.744011e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4130414}, {'UUID': 'NDD_SMR_genes_all_update_text_109453', 'Gene': 'DOC2A', 'topRSID': 'rs3814880', 'p_SMR_multi': 4.283307e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.03397242}, {'UUID': 'NDD_SMR_genes_all_update_text_577423', 'Gene': 'DOC2A', 'topRSID': 'rs7191849', 'p_SMR_multi': 4.54137e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3529978}, {'UUID': 'NDD_SMR_genes_all_update_text_577416', 'Gene': 'DOC2A', 'topRSID': 'rs11649149', 'p_SMR_multi': 5.919626e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1450694}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.818 | Q11 | Are there any CDIPT-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CDIPT-AS1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs889695
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.98e-07; HEIDI: 2.9597e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CDIPT-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577403', 'Gene': 'CDIPT-AS1', 'topRSID': 'rs889695', 'p_SMR_multi': 5.983115e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.959687e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1120 | Q11 | Are there any FAM47E SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the FAM47E gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4859657
• Cortex: Adjusted SMR multi-SNP P-value: 4.94e-07; HEIDI: 5.7553e-06
• rs1876538
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.14e-06; HEIDI: 1.2069e-04
• rs62303000
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.36e-06; HEIDI: 2.4740e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM47E' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140433', 'Gene': 'FAM47E', 'topRSID': 'rs4859657', 'p_SMR_multi': 4.944625e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.755268e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1430354', 'Gene': 'FAM47E', 'topRSID': 'rs1876538', 'p_SMR_multi': 1.143732e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.0001206915}, {'UUID': 'NDD_SMR_genes_all_update_text_432138', 'Gene': 'FAM47E', 'topRSID': 'rs62303000', 'p_SMR_multi': 2.362795e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.002473996}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.88 | Q11 | Are there any SNAP23 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene SNAP23 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SNAP23' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1183 | Q11 | Are there any SCIMP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SCIMP gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4790253
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.23e-08; HEIDI: 4.1311e-11
• rs12449702
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.46e-06; HEIDI: 2.4375e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SCIMP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501931', 'Gene': 'SCIMP', 'topRSID': 'rs4790253', 'p_SMR_multi': 6.226141e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.131138e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1291510', 'Gene': 'SCIMP', 'topRSID': 'rs12449702', 'p_SMR_multi': 2.46173e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.02437518}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1333 | Q11 | Are there any AC004528.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC004528.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC004528.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1806 | Q11 | Are there any SLC26A1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SLC26A1 gene has 4 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs3796622
• Cortex: Adjusted SMR multi-SNP P-value: 4.15e-09; HEIDI: 6.5086e-10
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.73e-06; HEIDI: 1.2326e-08
• rs3822020
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.95e-08; HEIDI: 2.6016e-09
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.98e-08; HEIDI: 1.0623e-09
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.67e-07; HEIDI: 4.3798e-07
• rs3806756
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.92e-07; HEIDI: 5.0229e-08
• rs11936407
• Cerebellum: Adjusted SMR multi-SNP P-value: 5.28e-07; HEIDI: 1.4172e-05
• Cortex: Adjusted SMR multi-SNP P-value: 5.28e-07; HEIDI: 3.1834e-06
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.64e-06; HEIDI: 9.1383e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SLC26A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1140278', 'Gene': 'SLC26A1', 'topRSID': 'rs3796622', 'p_SMR_multi': 4.148087e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 6.508625e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1323352', 'Gene': 'SLC26A1', 'topRSID': 'rs3822020', 'p_SMR_multi': 1.950696e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 2.60158e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1430185', 'Gene': 'SLC26A1', 'topRSID': 'rs3822020', 'p_SMR_multi': 4.984841e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.062306e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1555641', 'Gene': 'SLC26A1', 'topRSID': 'rs3806756', 'p_SMR_multi': 1.92297e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.022913e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1707343', 'Gene': 'SLC26A1', 'topRSID': 'rs11936407', 'p_SMR_multi': 5.277755e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.417229e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1259978', 'Gene': 'SLC26A1', 'topRSID': 'rs11936407', 'p_SMR_multi': 5.277958e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 3.18335e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_19051', 'Gene': 'SLC26A1', 'topRSID': 'rs3822020', 'p_SMR_multi': 9.665471e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 4.379803e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1188709', 'Gene': 'SLC26A1', 'topRSID': 'rs11936407', 'p_SMR_multi': 1.644477e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 9.138304e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1675611', 'Gene': 'SLC26A1', 'topRSID': 'rs3796622', 'p_SMR_multi': 1.734954e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.23261e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1819 | Q11 | Are there any STAG3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the STAG3 gene has 17 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs11767968
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.17e-11; HEIDI: 8.4803e-05
• rs1636988
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.18e-11; HEIDI: 1.3146e-04
• Cortex: Adjusted SMR multi-SNP P-value: 2.05e-09; HEIDI: 1.0038e-02
• rs34130487
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.16e-10; HEIDI: 3.7770e-03
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.18e-09; HEIDI: 4.0622e-01
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.17e-07; HEIDI: 4.8897e-01
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.18e-07; HEIDI: 5.5343e-01
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.88e-07; HEIDI: 5.2739e-01
• rs3779045
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.20e-10; HEIDI: 4.4200e-04
• rs7786505
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.20e-10; HEIDI: 2.8979e-02
• rs1727125
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.96e-10; HEIDI: 6.0249e-03
• rs2950520
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.34e-09; HEIDI: 4.6338e-03
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.89e-06; HEIDI: 1.6977e-01
• rs4299940
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.58e-09; HEIDI: 2.9851e-01
• rs1727124
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.99e-09; HEIDI: 1.1197e-02
• rs2070215
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.58e-08; HEIDI: 1.8185e-01
• Amygdala: Adjusted SMR multi-SNP P-value: 5.91e-07; HEIDI: 1.0256e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'STAG3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_74050', 'Gene': 'STAG3', 'topRSID': 'rs11767968', 'p_SMR_multi': 1.165779e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.480336e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_585987', 'Gene': 'STAG3', 'topRSID': 'rs1636988', 'p_SMR_multi': 1.178562e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001314553}, {'UUID': 'NDD_SMR_genes_all_update_text_585984', 'Gene': 'STAG3', 'topRSID': 'rs1636988', 'p_SMR_multi': 3.622464e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.907743e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1392624', 'Gene': 'STAG3', 'topRSID': 'rs34130487', 'p_SMR_multi': 1.16275e-10, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.003776984}, {'UUID': 'NDD_SMR_genes_all_update_text_585986', 'Gene': 'STAG3', 'topRSID': 'rs3779045', 'p_SMR_multi': 3.202729e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000442005}, {'UUID': 'NDD_SMR_genes_all_update_text_1495800', 'Gene': 'STAG3', 'topRSID': 'rs7786505', 'p_SMR_multi': 6.195954e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02897947}, {'UUID': 'NDD_SMR_genes_all_update_text_585982', 'Gene': 'STAG3', 'topRSID': 'rs1727125', 'p_SMR_multi': 8.958467e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.006024918}, {'UUID': 'NDD_SMR_genes_all_update_text_585985', 'Gene': 'STAG3', 'topRSID': 'rs1636988', 'p_SMR_multi': 1.084597e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001071303}, {'UUID': 'NDD_SMR_genes_all_update_text_1687933', 'Gene': 'STAG3', 'topRSID': 'rs34130487', 'p_SMR_multi': 1.184878e-09, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.406217}, {'UUID': 'NDD_SMR_genes_all_update_text_74047', 'Gene': 'STAG3', 'topRSID': 'rs11767968', 'p_SMR_multi': 1.399379e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.05192287}, {'UUID': 'NDD_SMR_genes_all_update_text_1105972', 'Gene': 'STAG3', 'topRSID': 'rs1636988', 'p_SMR_multi': 2.054704e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.01003834}, {'UUID': 'NDD_SMR_genes_all_update_text_1340317', 'Gene': 'STAG3', 'topRSID': 'rs2950520', 'p_SMR_multi': 2.342539e-09, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.00463376}, {'UUID': 'NDD_SMR_genes_all_update_text_74051', 'Gene': 'STAG3', 'topRSID': 'rs4299940', 'p_SMR_multi': 5.583436e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2985103}, {'UUID': 'NDD_SMR_genes_all_update_text_585981', 'Gene': 'STAG3', 'topRSID': 'rs1727124', 'p_SMR_multi': 8.989234e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01119652}, {'UUID': 'NDD_SMR_genes_all_update_text_74048', 'Gene': 'STAG3', 'topRSID': 'rs11767968', 'p_SMR_multi': 1.417518e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0927998}, {'UUID': 'NDD_SMR_genes_all_update_text_1716109', 'Gene': 'STAG3', 'topRSID': 'rs2070215', 'p_SMR_multi': 1.584787e-08, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.181851}, {'UUID': 'NDD_SMR_genes_all_update_text_74049', 'Gene': 'STAG3', 'topRSID': 'rs6465766', 'p_SMR_multi': 5.213861e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2040666}, {'UUID': 'NDD_SMR_genes_all_update_text_1266777', 'Gene': 'STAG3', 'topRSID': 'rs34130487', 'p_SMR_multi': 1.173964e-07, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.4889745}, {'UUID': 'NDD_SMR_genes_all_update_text_1245517', 'Gene': 'STAG3', 'topRSID': 'rs1727140', 'p_SMR_multi': 1.477897e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.0009789817}, {'UUID': 'NDD_SMR_genes_all_update_text_1583221', 'Gene': 'STAG3', 'topRSID': 'rs858513', 'p_SMR_multi': 1.4876e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 4.61023e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1377707', 'Gene': 'STAG3', 'topRSID': 'rs34130487', 'p_SMR_multi': 2.179524e-07, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.5534318}, {'UUID': 'NDD_SMR_genes_all_update_text_74046', 'Gene': 'STAG3', 'topRSID': 'rs6465766', 'p_SMR_multi': 2.356182e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1396711}, {'UUID': 'NDD_SMR_genes_all_update_text_1172873', 'Gene': 'STAG3', 'topRSID': 'rs34130487', 'p_SMR_multi': 2.876461e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.5273926}, {'UUID': 'NDD_SMR_genes_all_update_text_1597705', 'Gene': 'STAG3', 'topRSID': 'rs2070215', 'p_SMR_multi': 5.91439e-07, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.1025618}, {'UUID': 'NDD_SMR_genes_all_update_text_1446227', 'Gene': 'STAG3', 'topRSID': 'rs1987580', 'p_SMR_multi': 5.982321e-07, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.01389594}, {'UUID': 'NDD_SMR_genes_all_update_text_1453489', 'Gene': 'STAG3', 'topRSID': 'rs866500', 'p_SMR_multi': 6.65674e-07, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.4913814}, {'UUID': 'NDD_SMR_genes_all_update_text_585983', 'Gene': 'STAG3', 'topRSID': 'rs3823642', 'p_SMR_multi': 8.151617e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.09857146}, {'UUID': 'NDD_SMR_genes_all_update_text_1287871', 'Gene': 'STAG3', 'topRSID': 'rs13230744', 'p_SMR_multi': 2.223335e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.01948462}, {'UUID': 'NDD_SMR_genes_all_update_text_1156007', 'Gene': 'STAG3', 'topRSID': 'rs2950520', 'p_SMR_multi': 2.892444e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.1697678}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1374 | Q11 | Are there any KCNJ6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia and Cerebellum samples tested there are no SNPs within the gene KCNJ6 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KCNJ6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1144 | Q11 | Are there any RP11-426C22.4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-426C22.4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-426C22.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.367 | Q11 | Are there any RPS16 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RPS16 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RPS16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1790 | Q11 | Are there any USP29 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene USP29 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'USP29' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1208 | Q11 | Are there any FAM86JP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene FAM86JP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'FAM86JP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1035 | Q11 | Are there any DDX51 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene DDX51 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'DDX51' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1039 | Q11 | Are there any WASHC2A SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene WASHC2A that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'WASHC2A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1761 | Q11 | Are there any UBR4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene UBR4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UBR4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1357 | Q11 | Are there any ACE SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ACE gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4353
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.37e-09; HEIDI: 2.3251e-02
• rs6504163
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 9.73e-09; HEIDI: 4.8226e-08
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 4.73e-07; HEIDI: 2.4104e-01
• rs4291
• Cortex: Adjusted SMR multi-SNP P-value: 1.39e-08; HEIDI: 2.7215e-01
• rs4277405
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.16e-08; HEIDI: 5.7326e-01
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.02e-07; HEIDI: 1.3982e-01
• rs4459609
• Cerebellum: Adjusted SMR multi-SNP P-value: 6.23e-08; HEIDI: 5.5025e-01
• rs4292
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.33e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ACE' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_591980', 'Gene': 'ACE', 'topRSID': 'rs4353', 'p_SMR_multi': 3.370011e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02325148}, {'UUID': 'NDD_SMR_genes_all_update_text_1396839', 'Gene': 'ACE', 'topRSID': 'rs6504163', 'p_SMR_multi': 9.73321e-09, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 4.822616e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1106908', 'Gene': 'ACE', 'topRSID': 'rs4291', 'p_SMR_multi': 1.386269e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.2721482}, {'UUID': 'NDD_SMR_genes_all_update_text_1502600', 'Gene': 'ACE', 'topRSID': 'rs4277405', 'p_SMR_multi': 6.164485e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.5732641}, {'UUID': 'NDD_SMR_genes_all_update_text_2702', 'Gene': 'ACE', 'topRSID': 'rs4459609', 'p_SMR_multi': 6.234866e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.5502464}, {'UUID': 'NDD_SMR_genes_all_update_text_1203106', 'Gene': 'ACE', 'topRSID': 'rs6504163', 'p_SMR_multi': 4.725424e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.2410392}, {'UUID': 'NDD_SMR_genes_all_update_text_1610943', 'Gene': 'ACE', 'topRSID': 'rs4277405', 'p_SMR_multi': 8.024646e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.139824}, {'UUID': 'NDD_SMR_genes_all_update_text_1690104', 'Gene': 'ACE', 'topRSID': 'rs4292', 'p_SMR_multi': 1.330738e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1875 | Q11 | Are there any LILRB3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene LILRB3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LILRB3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.672 | Q11 | Are there any CTD-2562J17.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene CTD-2562J17.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CTD-2562J17.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.369 | Q11 | Are there any MYO1A SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood and Cortex samples tested there are no SNPs within the gene MYO1A that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MYO1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.80 | Q11 | Are there any CNPY4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CNPY4 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs77686669
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.83e-10; HEIDI: 7.8223e-09
• rs7457787
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.33e-08; HEIDI: 4.5089e-08
• rs11767968
• Cortex: Adjusted SMR multi-SNP P-value: 1.39e-06; HEIDI: 5.0378e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CNPY4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495794', 'Gene': 'CNPY4', 'topRSID': 'rs77686669', 'p_SMR_multi': 4.834994e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.822272e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1392619', 'Gene': 'CNPY4', 'topRSID': 'rs7457787', 'p_SMR_multi': 8.325836e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 4.508875e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1105969', 'Gene': 'CNPY4', 'topRSID': 'rs11767968', 'p_SMR_multi': 1.387083e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.00503778}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.28 | Q11 | Are there any SPPL2C SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the SPPL2C gene has 2 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs393152
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.26e-19; HEIDI: 4.3851e-16
• Cortex: Adjusted SMR multi-SNP P-value: 2.37e-14; HEIDI: 6.2253e-10
• rs1981997
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.66e-15; HEIDI: 9.5819e-14
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.58e-14; HEIDI: 1.2453e-11
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SPPL2C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_22216', 'Gene': 'SPPL2C', 'topRSID': 'rs393152', 'p_SMR_multi': 1.259583e-19, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 4.385134e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1714154', 'Gene': 'SPPL2C', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.662437e-15, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 9.581856e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1194215', 'Gene': 'SPPL2C', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.582867e-14, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.245263e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1154395', 'Gene': 'SPPL2C', 'topRSID': 'rs393152', 'p_SMR_multi': 2.367158e-14, 'Omic_tissue': 'Cortex', 'p_HEIDI': 6.22534e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1438 | Q11 | Are there any TREML4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREML4 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs6458200
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.04e-11; HEIDI: 3.7370e-04
• rs6458202
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.79e-08; HEIDI: 7.2601e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREML4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494871', 'Gene': 'TREML4', 'topRSID': 'rs6458200', 'p_SMR_multi': 1.039136e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003737034}, {'UUID': 'NDD_SMR_genes_all_update_text_622649', 'Gene': 'TREML4', 'topRSID': 'rs6458202', 'p_SMR_multi': 8.791275e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.260085e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.531 | Q11 | Are there any MS4A4A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MS4A4A gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1562990
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.70e-19; HEIDI: 1.1163e-02
• rs2017549
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.91e-11; HEIDI: 6.4879e-19
• rs1947360
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.96e-10; HEIDI: 8.1548e-12
• rs10750934
• Cortex: Adjusted SMR multi-SNP P-value: 1.66e-08; HEIDI: 9.1984e-09
• rs11230222
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.18e-08; HEIDI: 5.3438e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MS4A4A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498263', 'Gene': 'MS4A4A', 'topRSID': 'rs1562990', 'p_SMR_multi': 4.704043999999999e-19, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01116266}, {'UUID': 'NDD_SMR_genes_all_update_text_608695', 'Gene': 'MS4A4A', 'topRSID': 'rs2017549', 'p_SMR_multi': 4.911156e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.487850999999999e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_608697', 'Gene': 'MS4A4A', 'topRSID': 'rs1947360', 'p_SMR_multi': 1.960425e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.154847e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1112453', 'Gene': 'MS4A4A', 'topRSID': 'rs10750934', 'p_SMR_multi': 1.661163e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 9.198412e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1394258', 'Gene': 'MS4A4A', 'topRSID': 'rs11230222', 'p_SMR_multi': 8.179582e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.005343825}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1836 | Q11 | Are there any CTC-451A6.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene CTC-451A6.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTC-451A6.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.56 | Q11 | Are there any TNXB SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TNXB gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs34214527
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.41e-08; HEIDI: 2.8077e-04
• rs17201588
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.06e-07; HEIDI: 3.0143e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TNXB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621344', 'Gene': 'TNXB', 'topRSID': 'rs34214527', 'p_SMR_multi': 6.412823e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002807721}, {'UUID': 'NDD_SMR_genes_all_update_text_621377', 'Gene': 'TNXB', 'topRSID': 'rs17201588', 'p_SMR_multi': 1.059784e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3014339}, {'UUID': 'NDD_SMR_genes_all_update_text_621346', 'Gene': 'TNXB', 'topRSID': 'rs34214527', 'p_SMR_multi': 4.036833e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.479448e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_621421', 'Gene': 'TNXB', 'topRSID': 'rs17201588', 'p_SMR_multi': 5.289114e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2337775}, {'UUID': 'NDD_SMR_genes_all_update_text_621345', 'Gene': 'TNXB', 'topRSID': 'rs34214527', 'p_SMR_multi': 7.168879e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003789324}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.645 | Q11 | Are there any H4C6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene H4C6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'H4C6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.306 | Q11 | Are there any PDCL3P4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene PDCL3P4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PDCL3P4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.725 | Q11 | Are there any SVIP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SVIP that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SVIP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.631 | Q11 | Are there any AL157871.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AL157871.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AL157871.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.8 | Q11 | Are there any TP53INP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TP53INP1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs896853
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.40e-07; HEIDI: 9.6663e-09 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TP53INP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1393057', 'Gene': 'TP53INP1', 'topRSID': 'rs896853', 'p_SMR_multi': 8.400329e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 9.666325e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.810 | Q11 | Are there any PLAT SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene PLAT that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PLAT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1058 | Q11 | Are there any FIZ1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FIZ1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FIZ1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.340 | Q11 | Are there any TBKBP1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene TBKBP1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TBKBP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.48 | Q11 | Are there any TSPAN14 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TSPAN14 gene has 7 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7088877
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.21e-09; HEIDI: 1.9989e-02
• rs7086627
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.79e-08; HEIDI: 1.3972e-03
• rs4933390
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.71e-08; HEIDI: 6.1681e-04
• rs10749609
• Cortex: Adjusted SMR multi-SNP P-value: 1.59e-07; HEIDI: 8.9791e-01
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.37e-07; HEIDI: 1.5078e-01
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.13e-06; HEIDI: 8.3092e-10
• rs1993484
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.79e-07; HEIDI: 5.4540e-02
• rs12260962
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.46e-06; HEIDI: 3.3365e-06
• rs10788639
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.33e-06; HEIDI: 1.4428e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TSPAN14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572646', 'Gene': 'TSPAN14', 'topRSID': 'rs7088877', 'p_SMR_multi': 5.205964e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01998933}, {'UUID': 'NDD_SMR_genes_all_update_text_85783', 'Gene': 'TSPAN14', 'topRSID': 'rs7086627', 'p_SMR_multi': 2.786675e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001397175}, {'UUID': 'NDD_SMR_genes_all_update_text_85780', 'Gene': 'TSPAN14', 'topRSID': 'rs4933390', 'p_SMR_multi': 7.7079e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0006168139}, {'UUID': 'NDD_SMR_genes_all_update_text_1105563', 'Gene': 'TSPAN14', 'topRSID': 'rs10749609', 'p_SMR_multi': 1.590519e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.8979075}, {'UUID': 'NDD_SMR_genes_all_update_text_1200108', 'Gene': 'TSPAN14', 'topRSID': 'rs10749609', 'p_SMR_multi': 2.370245e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.1507844}, {'UUID': 'NDD_SMR_genes_all_update_text_572650', 'Gene': 'TSPAN14', 'topRSID': 'rs1993484', 'p_SMR_multi': 4.794606e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05454038}, {'UUID': 'NDD_SMR_genes_all_update_text_1393825', 'Gene': 'TSPAN14', 'topRSID': 'rs10749609', 'p_SMR_multi': 1.133209e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 8.309223e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1497629', 'Gene': 'TSPAN14', 'topRSID': 'rs12260962', 'p_SMR_multi': 1.463233e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.336469e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_572648', 'Gene': 'TSPAN14', 'topRSID': 'rs7088877', 'p_SMR_multi': 2.146195e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06520116}, {'UUID': 'NDD_SMR_genes_all_update_text_572649', 'Gene': 'TSPAN14', 'topRSID': 'rs10788639', 'p_SMR_multi': 2.327229e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.144281}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1481 | Q11 | Are there any CZIB SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene CZIB that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CZIB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.109 | Q11 | Are there any CTC-523E23.8 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene CTC-523E23.8 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTC-523E23.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.353 | Q11 | Are there any RPL19P12 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RPL19P12 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RPL19P12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.241 | Q11 | Are there any PHYH SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PHYH that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PHYH' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.216 | Q11 | Are there any CCDC148 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Whole Brain samples tested there are no SNPs within the gene CCDC148 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CCDC148' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1827 | Q11 | Are there any DNAJC28 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex and Skeletal Muscle samples tested there are no SNPs within the gene DNAJC28 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'DNAJC28' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1138 | Q11 | Are there any LOC91948 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LOC91948 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LOC91948' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.800 | Q11 | Are there any IGKV1-6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGKV1-6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'IGKV1-6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1123 | Q11 | Are there any AC072061.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC072061.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC072061.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1583 | Q11 | Are there any PSORS1C1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hypothalamus, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene PSORS1C1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PSORS1C1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1672 | Q11 | Are there any RABEP1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene RABEP1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RABEP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.529 | Q11 | Are there any MRPL22 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene MRPL22 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MRPL22' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.235 | Q11 | Are there any METTL27 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus and Cortex samples tested there are no SNPs within the gene METTL27 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'METTL27' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.651 | Q11 | Are there any GLOD4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene GLOD4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GLOD4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1509 | Q11 | Are there any AC073842.19 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AC073842.19 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11771139
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.12e-13; HEIDI: 6.1159e-05
• rs11505847
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.02e-11; HEIDI: 6.1868e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC073842.19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585975', 'Gene': 'AC073842.19', 'topRSID': 'rs11771139', 'p_SMR_multi': 4.115247e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.115948e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_74038', 'Gene': 'AC073842.19', 'topRSID': 'rs11505847', 'p_SMR_multi': 6.018154e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.006186833}, {'UUID': 'NDD_SMR_genes_all_update_text_585976', 'Gene': 'AC073842.19', 'topRSID': 'rs11771139', 'p_SMR_multi': 1.466512e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005393742}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.539 | Q11 | Are there any KIF1C SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KIF1C gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs3786046
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.98e-08; HEIDI: 6.7558e-03
• rs72835012
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.86e-06; HEIDI: 1.0865e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KIF1C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589041', 'Gene': 'KIF1C', 'topRSID': 'rs3786046', 'p_SMR_multi': 5.975266e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.006755758}, {'UUID': 'NDD_SMR_genes_all_update_text_589038', 'Gene': 'KIF1C', 'topRSID': 'rs72835012', 'p_SMR_multi': 2.856818e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.108651}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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