uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q11.1753 | Q11 | Are there any TOB2P1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene TOB2P1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TOB2P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.610 | Q11 | Are there any RPS19 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RPS19 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RPS19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1780 | Q11 | Are there any PTGES3L SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Prefrontal Cortex and Skeletal Muscle samples tested there are no SNPs within the gene PTGES3L that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PTGES3L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1083 | Q11 | Are there any FAM115D SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene FAM115D that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAM115D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1407 | Q11 | Are there any LRRK2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the LRRK2 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs4363681
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.07e-07; HEIDI: 1.9784e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRK2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1561430', 'Gene': 'LRRK2', 'topRSID': 'rs4363681', 'p_SMR_multi': 9.070753e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.978415e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.62 | Q11 | Are there any RP11-76C10.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-76C10.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-76C10.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1643 | Q11 | Are there any RAMP3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene RAMP3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RAMP3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.95 | Q11 | Are there any CST9 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CST9 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CST9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.673 | Q11 | Are there any AC096574.5 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood, Prefrontal Cortex and Skeletal Muscle samples tested there are no SNPs within the gene AC096574.5 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC096574.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.284 | Q11 | Are there any PHLDA3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene PHLDA3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PHLDA3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1796 | Q11 | Are there any NCAPD2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Cerebellum samples tested there are no SNPs within the gene NCAPD2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'NCAPD2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.364 | Q11 | Are there any CNKSR1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CNKSR1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CNKSR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1468 | Q11 | Are there any USP20 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene USP20 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'USP20' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1169 | Q11 | Are there any MYOM1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene MYOM1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MYOM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.854 | Q11 | Are there any ATP4B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ATP4B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ATP4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1379 | Q11 | Are there any DLGAP5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene DLGAP5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DLGAP5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.113 | Q11 | Are there any LSM5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LSM5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'LSM5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.43 | Q11 | Are there any PLCH2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PLCH2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PLCH2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.128 | Q11 | Are there any CRHR1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CRHR1 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17689882
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.89e-07; HEIDI: 8.5991e-03
• rs79923708
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 5.84e-07; HEIDI: 1.8205e-03
• rs113790915
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.46e-07; HEIDI: 1.8329e-01
• rs62062279
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.83e-07; HEIDI: 1.1471e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CRHR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_591172', 'Gene': 'CRHR1', 'topRSID': 'rs17689882', 'p_SMR_multi': 3.894906e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008599073}, {'UUID': 'NDD_SMR_genes_all_update_text_1203006', 'Gene': 'CRHR1', 'topRSID': 'rs79923708', 'p_SMR_multi': 5.838664e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.00182055}, {'UUID': 'NDD_SMR_genes_all_update_text_591169', 'Gene': 'CRHR1', 'topRSID': 'rs113790915', 'p_SMR_multi': 7.455325e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1832888}, {'UUID': 'NDD_SMR_genes_all_update_text_591171', 'Gene': 'CRHR1', 'topRSID': 'rs62062279', 'p_SMR_multi': 8.830123e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01147118}, {'UUID': 'NDD_SMR_genes_all_update_text_591170', 'Gene': 'CRHR1', 'topRSID': 'rs113790915', 'p_SMR_multi': 1.075968e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01605031}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.207 | Q11 | Are there any LOC100270710 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LOC100270710 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'LOC100270710' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.53 | Q11 | Are there any LGI1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood, Tibial Nerve and Liver samples tested there are no SNPs within the gene LGI1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LGI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.551 | Q11 | Are there any PPIHP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene PPIHP1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PPIHP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.71 | Q11 | Are there any PRR16 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Skeletal Muscle samples tested there are no SNPs within the gene PRR16 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRR16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1816 | Q11 | Are there any ARHGAP45 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ARHGAP45 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs117187726
• Cortex: Adjusted SMR multi-SNP P-value: 6.67e-09; HEIDI: 5.3982e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ARHGAP45' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1107633', 'Gene': 'ARHGAP45', 'topRSID': 'rs117187726', 'p_SMR_multi': 6.667181e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.398231e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1745 | Q11 | Are there any UBE2M SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene UBE2M that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'UBE2M' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.186 | Q11 | Are there any MT1L SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MT1L that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MT1L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.140 | Q11 | Are there any CYTIP SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CYTIP that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CYTIP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.907 | Q11 | Are there any GKN1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene GKN1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GKN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.803 | Q11 | Are there any ZNF627 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZNF627 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ZNF627' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.135 | Q11 | Are there any ADCY10P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ADCY10P1 gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62396334
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-12; HEIDI: 5.2923e-09
• rs78609059
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.61e-08; HEIDI: 8.7504e-10
• rs72856298
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.50e-07; HEIDI: 1.2665e-07
• rs72856293
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.60e-07; HEIDI: 9.2673e-08
• rs62396343
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 6.49e-07; HEIDI: 1.1720e-07
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADCY10P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494867', 'Gene': 'ADCY10P1', 'topRSID': 'rs62396334', 'p_SMR_multi': 1.117616e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.292267e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_622643', 'Gene': 'ADCY10P1', 'topRSID': 'rs78609059', 'p_SMR_multi': 3.61254e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.750358e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1287225', 'Gene': 'ADCY10P1', 'topRSID': 'rs72856298', 'p_SMR_multi': 3.498401e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.266494e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1649224', 'Gene': 'ADCY10P1', 'topRSID': 'rs72856293', 'p_SMR_multi': 4.601434e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.267346e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1391979', 'Gene': 'ADCY10P1', 'topRSID': 'rs62396343', 'p_SMR_multi': 6.486329e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.171977e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.83 | Q11 | Are there any NMD3P1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene NMD3P1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NMD3P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1541 | Q11 | Are there any AC090616.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC090616.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC090616.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.547 | Q11 | Are there any GULOP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the GULOP gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs6558008
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.32e-11; HEIDI: 1.1313e-04
• rs7465418
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.14e-10; HEIDI: 2.8748e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GULOP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_615765', 'Gene': 'GULOP', 'topRSID': 'rs6558008', 'p_SMR_multi': 1.318045e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001131265}, {'UUID': 'NDD_SMR_genes_all_update_text_615766', 'Gene': 'GULOP', 'topRSID': 'rs7465418', 'p_SMR_multi': 4.143028e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.874795e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1596 | Q11 | Are there any IGKV1D-13 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGKV1D-13 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IGKV1D-13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.992 | Q11 | Are there any ZNF487 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZNF487 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZNF487' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.168 | Q11 | Are there any C12orf55 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C12orf55 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'C12orf55' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.251 | Q11 | Are there any RP11-798G7.5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-798G7.5 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.48e-20; HEIDI: 5.1091e-13 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-798G7.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579414', 'Gene': 'RP11-798G7.5', 'topRSID': 'rs11012', 'p_SMR_multi': 1.4757229999999998e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.109127e-13}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.452 | Q11 | Are there any EPHX2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the EPHX2 gene has 7 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1126452
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.45e-16; HEIDI: 6.5131e-14
• rs73227337
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.50e-09; HEIDI: 1.5957e-02
• rs10096092
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.25e-08; HEIDI: 5.6614e-08
• rs36081056
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.66e-08; HEIDI: 4.9836e-05
• rs6994778
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.98e-08; HEIDI: 1.8550e-08
• rs17057245
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.69e-08; HEIDI: 4.9485e-06
• rs10104713
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.48e-08; HEIDI: 8.5554e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EPHX2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496307', 'Gene': 'EPHX2', 'topRSID': 'rs1126452', 'p_SMR_multi': 4.445184e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.513073e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_78248', 'Gene': 'EPHX2', 'topRSID': 'rs73227337', 'p_SMR_multi': 1.500668e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01595741}, {'UUID': 'NDD_SMR_genes_all_update_text_78249', 'Gene': 'EPHX2', 'topRSID': 'rs10096092', 'p_SMR_multi': 1.247194e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.661447e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_615760', 'Gene': 'EPHX2', 'topRSID': 'rs36081056', 'p_SMR_multi': 1.65609e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.983638e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_615761', 'Gene': 'EPHX2', 'topRSID': 'rs6994778', 'p_SMR_multi': 2.982034e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.854957e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_78251', 'Gene': 'EPHX2', 'topRSID': 'rs10096092', 'p_SMR_multi': 3.229097e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.067168e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_78253', 'Gene': 'EPHX2', 'topRSID': 'rs17057245', 'p_SMR_multi': 5.691527e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.948487e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_78250', 'Gene': 'EPHX2', 'topRSID': 'rs10104713', 'p_SMR_multi': 7.477494e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0008555384}, {'UUID': 'NDD_SMR_genes_all_update_text_78254', 'Gene': 'EPHX2', 'topRSID': 'rs10096092', 'p_SMR_multi': 7.950522e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.915712e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1148 | Q11 | Are there any LECT1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LECT1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LECT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.865 | Q11 | Are there any SPRYD4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SPRYD4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SPRYD4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1233 | Q11 | Are there any HCG17 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the HCG17 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs139747027
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.55e-06; HEIDI: 2.6106e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HCG17' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620392', 'Gene': 'HCG17', 'topRSID': 'rs139747027', 'p_SMR_multi': 2.546484e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2610588}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.100 | Q11 | Are there any SIGLEC11 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SIGLEC11 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SIGLEC11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1974 | Q11 | Are there any CTB-191K22.6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTB-191K22.6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTB-191K22.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.744 | Q11 | Are there any RP5-855D21.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Hypothalamus samples tested there are no SNPs within the gene RP5-855D21.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP5-855D21.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1252 | Q11 | Are there any C10orf68 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene C10orf68 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C10orf68' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.105 | Q11 | Are there any AC093673.5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AC093673.5 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1135411
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.35e-10; HEIDI: 4.5770e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC093673.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496069', 'Gene': 'AC093673.5', 'topRSID': 'rs1135411', 'p_SMR_multi': 5.347951e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004577002}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.440 | Q11 | Are there any NMT2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene NMT2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NMT2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.77 | Q11 | Are there any LCN15 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene LCN15 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LCN15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1793 | Q11 | Are there any PRPF4B SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene PRPF4B that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PRPF4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1462 | Q11 | Are there any MTND3P9 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene MTND3P9 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MTND3P9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.926 | Q11 | Are there any SQSTM1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SQSTM1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SQSTM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1712 | Q11 | Are there any OXTR SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hypothalamus, Whole Blood, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene OXTR that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'OXTR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1671 | Q11 | Are there any RP11-385F7.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-385F7.1 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4715019
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.22e-08; HEIDI: 5.4901e-02
• rs1931837
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.36e-08; HEIDI: 2.1840e-02
• rs9381564
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.62e-08; HEIDI: 3.9652e-01
• rs9369717
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 5.20e-07; HEIDI: 3.8642e-02
• rs12195738
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 6.49e-07; HEIDI: 3.3618e-01
• rs9473119
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.41e-06; HEIDI: 5.2478e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-385F7.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_67372', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs4715019', 'p_SMR_multi': 2.218978e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.05490125}, {'UUID': 'NDD_SMR_genes_all_update_text_622987', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs1931837', 'p_SMR_multi': 8.357727e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02183982}, {'UUID': 'NDD_SMR_genes_all_update_text_1687622', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs9381564', 'p_SMR_multi': 9.617745e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.3965234}, {'UUID': 'NDD_SMR_genes_all_update_text_1172618', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs9369717', 'p_SMR_multi': 5.195907e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.03864161}, {'UUID': 'NDD_SMR_genes_all_update_text_1287260', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs12195738', 'p_SMR_multi': 6.493e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.3361836}, {'UUID': 'NDD_SMR_genes_all_update_text_1607354', 'Gene': 'RP11-385F7.1', 'topRSID': 'rs9473119', 'p_SMR_multi': 1.410141e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.05247791}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1621 | Q11 | Are there any ANKRD26P4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene ANKRD26P4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ANKRD26P4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.769 | Q11 | Are there any RP11-1103G16.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-1103G16.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-1103G16.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.998 | Q11 | Are there any TXNDC5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene TXNDC5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TXNDC5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.394 | Q11 | Are there any RP11-293A21.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-293A21.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-293A21.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.238 | Q11 | Are there any GGT6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GGT6 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GGT6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1508 | Q11 | Are there any CD274 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CD274 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD274' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.270 | Q11 | Are there any ADD2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ADD2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADD2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1187 | Q11 | Are there any APOE SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the APOE gene has 2 SNPs that are statistically significant in Lewy Body Dementia. Here are the SNPs along with their adjusted SMR p-values:
• rs7259620
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.51e-15; HEIDI: 8.6724e-28
• rs769449
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.20e-12; HEIDI: 1.9308e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'APOE' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_402973', 'Gene': 'APOE', 'topRSID': 'rs7259620', 'p_SMR_multi': 1.514884e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.672375000000001e-28}, {'UUID': 'NDD_SMR_genes_all_update_text_402974', 'Gene': 'APOE', 'topRSID': 'rs7259620', 'p_SMR_multi': 1.349555e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.92925e-31}, {'UUID': 'NDD_SMR_genes_all_update_text_928299', 'Gene': 'APOE', 'topRSID': 'rs769449', 'p_SMR_multi': 2.195797e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001930753}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.120 | Q11 | Are there any BCKDK SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the BCKDK gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs4889619
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.33e-08; HEIDI: 4.0732e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BCKDK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501480', 'Gene': 'BCKDK', 'topRSID': 'rs4889619', 'p_SMR_multi': 7.332338e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4073159}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1607 | Q11 | Are there any APOC1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APOC1P1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs5112
• Liver: Adjusted SMR multi-SNP P-value: 2.43e-13; HEIDI: 1.0395e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOC1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1466878', 'Gene': 'APOC1P1', 'topRSID': 'rs5112', 'p_SMR_multi': 2.42788e-13, 'Omic_tissue': 'Liver', 'p_HEIDI': 1.039469e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.680 | Q11 | Are there any UBR2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene UBR2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'UBR2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.252 | Q11 | Are there any LAMTOR4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LAMTOR4 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs12878
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.04e-12; HEIDI: 7.4384e-07
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.34e-06; HEIDI: 3.5765e-03
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.45e-06; HEIDI: 2.6763e-04
• rs3736591
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.33e-08; HEIDI: 6.8542e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LAMTOR4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495796', 'Gene': 'LAMTOR4', 'topRSID': 'rs12878', 'p_SMR_multi': 2.035005e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.438358e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_585978', 'Gene': 'LAMTOR4', 'topRSID': 'rs3736591', 'p_SMR_multi': 2.327307e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.854238e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1172870', 'Gene': 'LAMTOR4', 'topRSID': 'rs12878', 'p_SMR_multi': 1.343762e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.003576456}, {'UUID': 'NDD_SMR_genes_all_update_text_74041', 'Gene': 'LAMTOR4', 'topRSID': 'rs12878', 'p_SMR_multi': 1.445543e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0002676306}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1958 | Q11 | Are there any PVRL2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PVRL2 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17561351
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.64e-80; HEIDI: -9.9990e+03
• rs60389450
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.05e-17; HEIDI: 2.8874e-16
• rs440277
• Liver: Adjusted SMR multi-SNP P-value: 8.96e-13; HEIDI: 5.4597e-23
• rs3810143
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 6.92e-12; HEIDI: 2.8729e-13
• rs149529419
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.51e-09; HEIDI: -9.9990e+03
• rs1871046
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.28e-07; HEIDI: 5.9642e-10
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.56e-06; HEIDI: 1.3829e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PVRL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503906', 'Gene': 'PVRL2', 'topRSID': 'rs17561351', 'p_SMR_multi': 2.635403e-80, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1653157', 'Gene': 'PVRL2', 'topRSID': 'rs60389450', 'p_SMR_multi': 1.045403e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.887377e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1466877', 'Gene': 'PVRL2', 'topRSID': 'rs440277', 'p_SMR_multi': 8.956061e-13, 'Omic_tissue': 'Liver', 'p_HEIDI': 5.459670000000001e-23}, {'UUID': 'NDD_SMR_genes_all_update_text_1343794', 'Gene': 'PVRL2', 'topRSID': 'rs3810143', 'p_SMR_multi': 6.915125e-12, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 2.872884e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_637426', 'Gene': 'PVRL2', 'topRSID': 'rs149529419', 'p_SMR_multi': 5.514291e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_122461', 'Gene': 'PVRL2', 'topRSID': 'rs1871046', 'p_SMR_multi': 8.280413e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.964197e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_637425', 'Gene': 'PVRL2', 'topRSID': 'rs1871046', 'p_SMR_multi': 1.557218e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.382928e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1995 | Q11 | Are there any NRIP2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Basal Ganglia, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene NRIP2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NRIP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.97 | Q11 | Are there any ADPGK SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene ADPGK that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADPGK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.34 | Q11 | Are there any MRPS31 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex, Frontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene MRPS31 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MRPS31' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1465 | Q11 | Are there any LRRC37A4P SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the LRRC37A4P gene has 3 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs11012
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.48e-39; HEIDI: 4.0067e-41
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.90e-33; HEIDI: 8.1190e-04
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.64e-18; HEIDI: 7.7093e-09
• rs12373139
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.92e-35; HEIDI: 9.2986e-26
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.50e-31; HEIDI: 1.5730e-19
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 8.37e-27; HEIDI: 3.3131e-22
• rs1981997
• Cortex: Adjusted SMR multi-SNP P-value: 2.28e-21; HEIDI: 5.4303e-26
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.10e-21; HEIDI: 1.0192e-23
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 3.33e-21; HEIDI: 1.4354e-25
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.41e-20; HEIDI: 2.4718e-24
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.10e-19; HEIDI: 9.5085e-24
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.00e-19; HEIDI: 2.6660e-25
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.80e-19; HEIDI: 7.8960e-24
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.46e-18; HEIDI: 5.3667e-20
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.04e-18; HEIDI: 1.4063e-21
• Liver: Adjusted SMR multi-SNP P-value: 2.72e-18; HEIDI: 3.6112e-19
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 9.03e-18; HEIDI: 1.1001e-18
• Amygdala: Adjusted SMR multi-SNP P-value: 1.12e-15; HEIDI: 2.3112e-19
• Substantia nigra: Adjusted SMR multi-SNP P-value: 1.68e-14; HEIDI: 5.3632e-10
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LRRC37A4P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1444269', 'Gene': 'LRRC37A4P', 'topRSID': 'rs11012', 'p_SMR_multi': 4.478326e-39, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 4.006733e-41}, {'UUID': 'NDD_SMR_genes_all_update_text_1684928', 'Gene': 'LRRC37A4P', 'topRSID': 'rs12373139', 'p_SMR_multi': 4.923862e-35, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.298631e-26}, {'UUID': 'NDD_SMR_genes_all_update_text_1646037', 'Gene': 'LRRC37A4P', 'topRSID': 'rs11012', 'p_SMR_multi': 6.904322e-33, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0008119001}, {'UUID': 'NDD_SMR_genes_all_update_text_1336282', 'Gene': 'LRRC37A4P', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.501241e-31, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.5729829999999998e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1375923', 'Gene': 'LRRC37A4P', 'topRSID': 'rs12373139', 'p_SMR_multi': 8.369824000000001e-27, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 3.313104e-22}, {'UUID': 'NDD_SMR_genes_all_update_text_1264977', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.280586e-21, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.430274e-26}, {'UUID': 'NDD_SMR_genes_all_update_text_1714149', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.09993e-21, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.019179e-23}, {'UUID': 'NDD_SMR_genes_all_update_text_1732390', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.325569e-21, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.435398e-25}, {'UUID': 'NDD_SMR_genes_all_update_text_1283697', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.414601e-20, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 2.471783e-24}, {'UUID': 'NDD_SMR_genes_all_update_text_1388478', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.096563e-19, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 9.508503e-24}, {'UUID': 'NDD_SMR_genes_all_update_text_1170869', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.997253e-19, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 2.66596e-25}, {'UUID': 'NDD_SMR_genes_all_update_text_1194210', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.800524e-19, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 7.896035e-24}, {'UUID': 'NDD_SMR_genes_all_update_text_1464413', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.457153e-18, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 5.3666859999999995e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1489533', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.043699e-18, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 1.406316e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1579415', 'Gene': 'LRRC37A4P', 'topRSID': 'rs11012', 'p_SMR_multi': 2.6425950000000002e-18, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.709293e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1478182', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.715656e-18, 'Omic_tissue': 'Liver', 'p_HEIDI': 3.611203e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1596818', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 9.033016e-18, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 1.1001010000000001e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1604709', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.118734e-15, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 2.311169e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1452478', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.679832e-14, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 5.363232e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1668 | Q11 | Are there any KB-226F1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Liver, Whole Blood and Cerebellum samples tested there are no SNPs within the gene KB-226F1.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KB-226F1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.454 | Q11 | Are there any DUOXA1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Blood, Cortex, Tibial Nerve and Whole Brain samples tested there are no SNPs within the gene DUOXA1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'DUOXA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.723 | Q11 | Are there any OR7E7P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle, Liver and Cerebellum samples tested there are no SNPs within the gene OR7E7P that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OR7E7P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1261 | Q11 | Are there any SNRNP25 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Liver, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SNRNP25 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SNRNP25' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1598 | Q11 | Are there any LTA SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene LTA that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LTA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1 | Q11 | Are there any CPLX1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CPLX1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6848474
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.32e-07; HEIDI: 2.0401e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CPLX1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_657229', 'Gene': 'CPLX1', 'topRSID': 'rs6848474', 'p_SMR_multi': 7.32026e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2040095}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1377 | Q11 | Are there any RP11-141J13.5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Skeletal Muscle samples tested there are no SNPs within the gene RP11-141J13.5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-141J13.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1110 | Q11 | Are there any RP11-182N22.8 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-182N22.8 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-182N22.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1117 | Q11 | Are there any TCAM1P SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene TCAM1P that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TCAM1P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1591 | Q11 | Are there any FBXO28 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene FBXO28 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FBXO28' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.85 | Q11 | Are there any GUCA2B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene GUCA2B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GUCA2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1294 | Q11 | Are there any PPP1R18 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Liver samples tested there are no SNPs within the gene PPP1R18 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PPP1R18' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.683 | Q11 | Are there any WISP2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain samples tested there are no SNPs within the gene WISP2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'WISP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1677 | Q11 | Are there any MARCHF8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene MARCHF8 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MARCHF8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1055 | Q11 | Are there any SCNM1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SCNM1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SCNM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.777 | Q11 | Are there any STK36 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene STK36 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'STK36' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1289 | Q11 | Are there any UNK SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene UNK that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'UNK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1946 | Q11 | Are there any CPSF6 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CPSF6 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CPSF6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1581 | Q11 | Are there any RAB8B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RAB8B gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11858666
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.45e-07; HEIDI: 7.5140e-01
• rs2729793
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.97e-07; HEIDI: 1.6166e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RAB8B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_105698', 'Gene': 'RAB8B', 'topRSID': 'rs11858666', 'p_SMR_multi': 3.453414e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.7513961}, {'UUID': 'NDD_SMR_genes_all_update_text_646596', 'Gene': 'RAB8B', 'topRSID': 'rs2729793', 'p_SMR_multi': 4.974919e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001616564}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1490 | Q11 | Are there any LYPLA2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene LYPLA2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LYPLA2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.410 | Q11 | Are there any C1orf147 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene C1orf147 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C1orf147' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1728 | Q11 | Are there any TREM1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREM1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs4714449
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.30e-11; HEIDI: 3.3449e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494874', 'Gene': 'TREM1', 'topRSID': 'rs4714449', 'p_SMR_multi': 3.29639e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003344938}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1298 | Q11 | Are there any MAP2K5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MAP2K5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MAP2K5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1665 | Q11 | Are there any TMEM163 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the TMEM163 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11684785
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.30e-06; HEIDI: 1.6038e-06
• rs57891859
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.00e-06; HEIDI: 1.8484e-01
• rs4440018
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.94e-06; HEIDI: 9.7518e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TMEM163' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1554334', 'Gene': 'TMEM163', 'topRSID': 'rs11684785', 'p_SMR_multi': 1.30336e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.603795e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1019152', 'Gene': 'TMEM163', 'topRSID': 'rs57891859', 'p_SMR_multi': 1.998553e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1848392}, {'UUID': 'NDD_SMR_genes_all_update_text_1019149', 'Gene': 'TMEM163', 'topRSID': 'rs4440018', 'p_SMR_multi': 2.940777e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.751796e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.107 | Q11 | Are there any RP11-309L24.6 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Skeletal Muscle samples tested there are no SNPs within the gene RP11-309L24.6 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-309L24.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.695 | Q11 | Are there any Z82214.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene Z82214.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'Z82214.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1305 | Q11 | Are there any ATF6B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ATF6B gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs41316748
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.18e-07; HEIDI: 1.5012e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ATF6B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621490', 'Gene': 'ATF6B', 'topRSID': 'rs41316748', 'p_SMR_multi': 1.175583e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1501221}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.833 | Q11 | Are there any HIST1H4H SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Skeletal Muscle, Liver and Whole Blood samples tested there are no SNPs within the gene HIST1H4H that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HIST1H4H' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.64 | Q11 | Are there any RP11-448P19.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-448P19.1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs10750540
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.43e-07; HEIDI: 4.9745e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-448P19.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_961094', 'Gene': 'RP11-448P19.1', 'topRSID': 'rs10750540', 'p_SMR_multi': 1.434394e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004974471}, {'UUID': 'NDD_SMR_genes_all_update_text_961091', 'Gene': 'RP11-448P19.1', 'topRSID': 'rs10750540', 'p_SMR_multi': 2.205039e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01769001}, {'UUID': 'NDD_SMR_genes_all_update_text_961093', 'Gene': 'RP11-448P19.1', 'topRSID': 'rs10750540', 'p_SMR_multi': 3.774325e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004959283}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.859 | Q11 | Are there any METTL8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene METTL8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'METTL8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.