uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
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|---|---|---|---|---|---|---|---|---|
Q67.178 | Q67 | What is the top-associated SNP of the gene KIF6 in Whole Blood mQTL omic data for PSP and is it functionally significant? | There are no SNPs within the gene KIF6 in Whole Blood mQTL omic data that are significantly associated with PSP, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KIF6" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1101628', 'topRSID': 'rs11758206', 'Disease': 'PSP', 'Gene': 'KIF6', 'p_SMR_multi': 0.07144112, 'p_HEIDI': 0.5249766, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_1101630', 'to... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.470 | Q67 | What is the top-associated SNP of the gene SNCA in Whole Blood mQTL omic data for LBD and is it functionally significant? | The top-associated SNP for SNCA in Whole Blood mQTL omic data for LBD is rs1372520, which has a multi-SNP SMR p-value of 1.65e-08 and a HEIDI of 0.03, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SNCA" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_934862', 'topRSID': 'rs2301134', 'Disease': 'LBD', 'Gene': 'SNCA', 'p_SMR_multi': 3.123872e-10, 'p_HEIDI': 0.8604982, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_934864', 'topRSID... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1337 | Q67 | What is the top-associated SNP of the gene SPPL2C in Cerebellum eQTL omic data for PD and is it functionally significant? | The top-associated SNP for SPPL2C in Cerebellum eQTL omic data for PD is rs17573607, which has a multi-SNP SMR p-value of 1.34e-10 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SPPL2C" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%cerebellum eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_19646', 'topRSID': 'rs2532233', 'Disease': 'PD', 'Gene': 'SPPL2C', 'p_SMR_multi': 1.566455e-11, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Cerebellum', 'Omic_type': 'Cerebellum eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequilibri... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1611 | Q67 | What is the top-associated SNP of the gene HSD3B7 in Whole Blood eQTL eQTLgen omic data for PD and is it functionally significant? | The top-associated SNP for HSD3B7 in Whole Blood eQTL eQTLgen omic data for PD is rs4889606, which has a multi-SNP SMR p-value of 7.67e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "HSD3B7" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563808', 'topRSID': 'rs4889606', 'Disease': 'PD', 'Gene': 'HSD3B7', 'p_SMR_multi': 7.667319e-07, 'p_HEIDI': 3.705421e-05, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Lin... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.126 | Q67 | What is the top-associated SNP of the gene IGSF9B in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for IGSF9B in Whole Brain meta-analysis mQTL omic data for PD is rs11223627, which has a multi-SNP SMR p-value of 6.34e-09 and a HEIDI of 0.24, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "IGSF9B" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_470339', 'topRSID': 'rs1793680', 'Disease': 'PD', 'Gene': 'IGSF9B', 'p_SMR_multi': 2.071103e-10, 'p_HEIDI': 0.006061729, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.355 | Q67 | What is the top-associated SNP of the gene GATS in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for AD and is it functionally significant? | The top-associated SNP for GATS in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for AD is rs1617502, which has a multi-SNP SMR p-value of 1.77e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GATS" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1392625', 'topRSID': 'rs1617502', 'Disease': 'AD', 'Gene': 'GATS', 'p_SMR_multi': 1.767868e-07, 'p_HEIDI': 4.781059e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'association meets significance thresho... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.388 | Q67 | What is the top-associated SNP of the gene RP11-259G18.3 in Liver eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for RP11-259G18.3 in Liver eQTL omic data for PSP is rs1981997, which has a multi-SNP SMR p-value of 1.69e-22 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-259G18.3" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%liver eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1478189', 'topRSID': 'rs1981997', 'Disease': 'PSP', 'Gene': 'RP11-259G18.3', 'p_SMR_multi': 1.6939850000000002e-22, 'p_HEIDI': 1.827604e-21, 'Omic_tissue': 'Liver', 'Omic_type': 'Liver eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linka... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1435 | Q67 | What is the top-associated SNP of the gene GAK in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for GAK in Whole Brain meta-analysis mQTL omic data for PD is rs11248057, which has a multi-SNP SMR p-value of 3.22e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GAK" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_429832', 'topRSID': 'rs11248057', 'Disease': 'PD', 'Gene': 'GAK', 'p_SMR_multi': 1.488653e-10, 'p_HEIDI': 1.165356e-06, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1007 | Q67 | What is the top-associated SNP of the gene TRIM40 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for TRIM40 in Whole Blood mQTL omic data for AD is rs114882073, which has a multi-SNP SMR p-value of 5.65e-07 and a HEIDI of 0.79, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TRIM40" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620281', 'topRSID': 'rs115938232', 'Disease': 'AD', 'Gene': 'TRIM40', 'p_SMR_multi': 3.571278e-07, 'p_HEIDI': 0.7820669, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_620283', 'topR... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.894 | Q67 | What is the top-associated SNP of the gene FLNB-AS1 in Whole Blood eQTL eQTLgen omic data for FTD and is it functionally significant? | There are no SNPs within the gene FLNB-AS1 in Whole Blood eQTL eQTLgen omic data that are significantly associated with FTD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "FLNB-AS1" AND Disease = "FTD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1524072', 'topRSID': 'rs2362902', 'Disease': 'FTD', 'Gene': 'FLNB-AS1', 'p_SMR_multi': 0.9809998, 'p_HEIDI': 0.3522161, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1495 | Q67 | What is the top-associated SNP of the gene ADAM15 in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for ADAM15 in Whole Brain meta-analysis mQTL omic data for PD is rs11264305, which has a multi-SNP SMR p-value of 1.86e-06 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ADAM15" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_415490', 'topRSID': 'rs11264305', 'Disease': 'PD', 'Gene': 'ADAM15', 'p_SMR_multi': 1.857978e-06, 'p_HEIDI': 0.005054781, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.335 | Q67 | What is the top-associated SNP of the gene RP11-259G18.1 in Cortex eQTL GTEx omic data for PSP and is it functionally significant? | The top-associated SNP for RP11-259G18.1 in Cortex eQTL GTEx omic data for PSP is rs1981997, which has a multi-SNP SMR p-value of 6.87e-14 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-259G18.1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%cortex eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1264985', 'topRSID': 'rs1981997', 'Disease': 'PSP', 'Gene': 'RP11-259G18.1', 'p_SMR_multi': 6.872455e-14, 'p_HEIDI': 5.296527e-12, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL GTEx', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.975 | Q67 | What is the top-associated SNP of the gene MICE in Skeletal Muscle eQTL omic data for PD and is it functionally significant? | There are no SNPs within the gene MICE in Skeletal Muscle eQTL omic data that are significantly associated with PD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MICE" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1367147', 'topRSID': 'rs9258229', 'Disease': 'PD', 'Gene': 'MICE', 'p_SMR_multi': 0.5280513, 'p_HEIDI': 0.7315096, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.197 | Q67 | What is the top-associated SNP of the gene CAMK1D in Whole Blood mQTL omic data for AD and is it functionally significant? | There are no SNPs within the gene CAMK1D in Whole Blood mQTL omic data that are significantly associated with AD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CAMK1D" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_570975', 'topRSID': 'rs7094879', 'Disease': 'AD', 'Gene': 'CAMK1D', 'p_SMR_multi': 0.04202303, 'p_HEIDI': 0.555317, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_570976', 'topRS... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.520 | Q67 | What is the top-associated SNP of the gene C9orf72 in Cortex eQTL GTEx omic data for ALS and is it functionally significant? | The top-associated SNP for C9orf72 in Cortex eQTL GTEx omic data for ALS is rs774358, which has a multi-SNP SMR p-value of 4.08e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "C9orf72" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%cortex eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1249608', 'topRSID': 'rs774358', 'Disease': 'ALS', 'Gene': 'C9orf72', 'p_SMR_multi': 4.080217e-08, 'p_HEIDI': 0.002146774, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL GTEx', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequil... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.459 | Q67 | What is the top-associated SNP of the gene NSFP1 in Amygdala eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for NSFP1 in Amygdala eQTL omic data for PSP is rs4792831, which has a multi-SNP SMR p-value of 4.71e-10 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "NSFP1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%amygdala eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1604718', 'topRSID': 'rs4792831', 'Disease': 'PSP', 'Gene': 'NSFP1', 'p_SMR_multi': 4.706001e-10, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Amygdala', 'Omic_type': 'Amygdala eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1714 | Q67 | What is the top-associated SNP of the gene RP11-27N21.3 in Prefrontal Cortex eQTL omic data for ALS and is it functionally significant? | There are no SNPs within the gene RP11-27N21.3 in Prefrontal Cortex eQTL omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-27N21.3" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%prefrontal cortex eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1209299', 'topRSID': 'rs2440660', 'Disease': 'ALS', 'Gene': 'RP11-27N21.3', 'p_SMR_multi': 0.5990136, 'p_HEIDI': 0.146978, 'Omic_tissue': 'Prefrontal Cortex', 'Omic_type': 'Prefrontal Cortex eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.326 | Q67 | What is the top-associated SNP of the gene RP11-259G18.3 in Caudate Basal Ganglia eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for RP11-259G18.3 in Caudate Basal Ganglia eQTL omic data for PSP is rs169201, which has a multi-SNP SMR p-value of 3.12e-21 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-259G18.3" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%caudate basal ganglia eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1283705', 'topRSID': 'rs169201', 'Disease': 'PSP', 'Gene': 'RP11-259G18.3', 'p_SMR_multi': 3.119082e-21, 'p_HEIDI': 4.913538e-13, 'Omic_tissue': 'Caudate Basal Ganglia', 'Omic_type': 'Caudate Basal Ganglia eQTL', 'func_sig': 'association meets significance threshold but shows si... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1323 | Q67 | What is the top-associated SNP of the gene CTB-171A8.1 in Whole Brain meta-analysis mQTL omic data for AD and is it functionally significant? | The top-associated SNP for CTB-171A8.1 in Whole Brain meta-analysis mQTL omic data for AD is rs10410915, which has a multi-SNP SMR p-value of 3.30e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CTB-171A8.1" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122446', 'topRSID': 'rs10410915', 'Disease': 'AD', 'Gene': 'CTB-171A8.1', 'p_SMR_multi': 3.296369e-08, 'p_HEIDI': 0.0001542126, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs of l... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.269 | Q67 | What is the top-associated SNP of the gene SRP9 in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for ALS and is it functionally significant? | There are no SNPs within the gene SRP9 in Multi Ancestry Whole Brain Meta-analysis eQTL omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SRP9" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1399519', 'topRSID': 'rs11583078', 'Disease': 'ALS', 'Gene': 'SRP9', 'p_SMR_multi': 0.7776428, 'p_HEIDI': 0.667874, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.799 | Q67 | What is the top-associated SNP of the gene CTB-171A8.1 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for CTB-171A8.1 in Whole Blood mQTL omic data for AD is rs2301274, which has a multi-SNP SMR p-value of 4.08e-08 and a HEIDI of 0.05, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CTB-171A8.1" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637412', 'topRSID': 'rs2301274', 'Disease': 'AD', 'Gene': 'CTB-171A8.1', 'p_SMR_multi': 4.081727e-08, 'p_HEIDI': 0.04512384, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_637410', '... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1432 | Q67 | What is the top-associated SNP of the gene POMGNT2 in Nucleus Accumbens Basal Ganglia omic data for PD and is it functionally significant? | There are no SNPs within the gene POMGNT2 in Nucleus Accumbens Basal Ganglia omic data that are significantly associated with PD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "POMGNT2" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%nucleus accumbens basal ganglia%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1728050', 'topRSID': 'rs4683356', 'Disease': 'PD', 'Gene': 'POMGNT2', 'p_SMR_multi': 0.6364749, 'p_HEIDI': 0.5137737, 'Omic_tissue': 'Nucleus Accumbens Basal', 'Omic_type': 'Nucleus Accumbens Basal Ganglia', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.70 | Q67 | What is the top-associated SNP of the gene KANSL1 in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for KANSL1 in Whole Brain meta-analysis mQTL omic data for PD is rs41374248, which has a multi-SNP SMR p-value of 2.08e-07 and a HEIDI of 0.75, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KANSL1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_491139', 'topRSID': 'rs12150087', 'Disease': 'PD', 'Gene': 'KANSL1', 'p_SMR_multi': 8.107128999999999e-20, 'p_HEIDI': 0.009069932, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs o... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.938 | Q67 | What is the top-associated SNP of the gene MAPT in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT in Whole Blood mQTL omic data for PD is rs111970616, which has a multi-SNP SMR p-value of 1.52e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948891', 'topRSID': 'rs62063271', 'Disease': 'PD', 'Gene': 'MAPT', 'p_SMR_multi': 6.382411e-15, 'p_HEIDI': 2.368028e-06, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Diseq... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1447 | Q67 | What is the top-associated SNP of the gene RP11-120K18.3 in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for RP11-120K18.3 in Whole Blood eQTL eQTLgen omic data for AD is rs11574631, which has a multi-SNP SMR p-value of 9.87e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-120K18.3" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501485', 'topRSID': 'rs11574631', 'Disease': 'AD', 'Gene': 'RP11-120K18.3', 'p_SMR_multi': 9.866759e-07, 'p_HEIDI': 0.001039313, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linka... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1782 | Q67 | What is the top-associated SNP of the gene NDUFAF6 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for NDUFAF6 in Whole Blood mQTL omic data for AD is rs1320164, which has a multi-SNP SMR p-value of 1.72e-06 and a HEIDI of 0.26, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "NDUFAF6" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_616798', 'topRSID': 'rs1320164', 'Disease': 'AD', 'Gene': 'NDUFAF6', 'p_SMR_multi': 1.716817e-06, 'p_HEIDI': 0.2600196, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_616796', 'topRS... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.468 | Q67 | What is the top-associated SNP of the gene EXOC3L2 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for EXOC3L2 in Whole Blood mQTL omic data for AD is rs41561512, which has a multi-SNP SMR p-value of 3.29e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "EXOC3L2" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637468', 'topRSID': 'rs41561512', 'Disease': 'AD', 'Gene': 'EXOC3L2', 'p_SMR_multi': 3.293403e-07, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequi... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1396 | Q67 | What is the top-associated SNP of the gene TRMT112 in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene TRMT112 in Multi Ancestry Whole Brain Meta-analysis eQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TRMT112" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 1... | [{'UUID': 'NDD_SMR_genes_all_update_text_1423688', 'topRSID': 'rs1806967', 'Disease': 'LBD', 'Gene': 'TRMT112', 'p_SMR_multi': 0.6009624, 'p_HEIDI': 0.4604544, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1614 | Q67 | What is the top-associated SNP of the gene DND1P1 in Skeletal Muscle eQTL omic data for PD and is it functionally significant? | The top-associated SNP for DND1P1 in Skeletal Muscle eQTL omic data for PD is rs55974014, which has a multi-SNP SMR p-value of 4.65e-15 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "DND1P1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1370540', 'topRSID': 'rs55974014', 'Disease': 'PD', 'Gene': 'DND1P1', 'p_SMR_multi': 4.645815e-15, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.549 | Q67 | What is the top-associated SNP of the gene GAK in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for GAK in Whole Blood mQTL omic data for PD is rs150789675, which has a multi-SNP SMR p-value of 8.91e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GAK" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996273', 'topRSID': 'rs12651271', 'Disease': 'PD', 'Gene': 'GAK', 'p_SMR_multi': 6.180527e-09, 'p_HEIDI': 3.619298e-07, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.538 | Q67 | What is the top-associated SNP of the gene TOMM40 in Whole Brain eQTL omic data for LBD and is it functionally significant? | The top-associated SNP for TOMM40 in Whole Brain eQTL omic data for LBD is rs7259620, which has a multi-SNP SMR p-value of 9.75e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TOMM40" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole brain eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1633475', 'topRSID': 'rs7259620', 'Disease': 'LBD', 'Gene': 'TOMM40', 'p_SMR_multi': 9.749371e-08, 'p_HEIDI': 3.932821e-15, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Di... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1230 | Q67 | What is the top-associated SNP of the gene RP11-173M11.2 in Tibial Nerve eQTL omic data for FTD and is it functionally significant? | There are no SNPs within the gene RP11-173M11.2 in Tibial Nerve eQTL omic data that are significantly associated with FTD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-173M11.2" AND Disease = "FTD" AND LOWER(Omic_type) LIKE "%tibial nerve eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1305311', 'topRSID': 'rs62350484', 'Disease': 'FTD', 'Gene': 'RP11-173M11.2', 'p_SMR_multi': 0.8893337, 'p_HEIDI': 0.8473265, 'Omic_tissue': 'Tibial Nerve', 'Omic_type': 'Tibial Nerve eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.957 | Q67 | What is the top-associated SNP of the gene MAPT-AS1 in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT-AS1 in Whole Blood mQTL omic data for PD is rs169201, which has a multi-SNP SMR p-value of 3.39e-10 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT-AS1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948871', 'topRSID': 'rs78026984', 'Disease': 'PD', 'Gene': 'MAPT-AS1', 'p_SMR_multi': 1.185713e-13, 'p_HEIDI': 1.052222e-05, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage D... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1635 | Q67 | What is the top-associated SNP of the gene KIF1C in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for KIF1C in Whole Blood mQTL omic data for AD is rs72835012, which has a multi-SNP SMR p-value of 2.86e-06 and a HEIDI of 0.11, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KIF1C" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589041', 'topRSID': 'rs3786046', 'Disease': 'AD', 'Gene': 'KIF1C', 'p_SMR_multi': 5.975266e-08, 'p_HEIDI': 0.006755758, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1418 | Q67 | What is the top-associated SNP of the gene RP11-458D21.1 in Whole Blood mQTL omic data for PSP and is it functionally significant? | There are no SNPs within the gene RP11-458D21.1 in Whole Blood mQTL omic data that are significantly associated with PSP, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-458D21.1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1065105', 'topRSID': 'rs9245', 'Disease': 'PSP', 'Gene': 'RP11-458D21.1', 'p_SMR_multi': 0.08029216, 'p_HEIDI': 0.5798164, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.422 | Q67 | What is the top-associated SNP of the gene TOMM40L in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for TOMM40L in Whole Blood eQTL eQTLgen omic data for AD is rs5082, which has a multi-SNP SMR p-value of 1.40e-06 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TOMM40L" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1490910', 'topRSID': 'rs5082', 'Disease': 'AD', 'Gene': 'TOMM40L', 'p_SMR_multi': 1.395985e-06, 'p_HEIDI': 9.026045e-05, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linka... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1935 | Q67 | What is the top-associated SNP of the gene GPNMB in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for PD and is it functionally significant? | The top-associated SNP for GPNMB in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for PD is rs858275, which has a multi-SNP SMR p-value of 1.08e-08 and a HEIDI of 0.01, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GPNMB" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1431548', 'topRSID': 'rs858275', 'Disease': 'PD', 'Gene': 'GPNMB', 'p_SMR_multi': 1.080397e-08, 'p_HEIDI': 0.01046363, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1532 | Q67 | What is the top-associated SNP of the gene RETSAT in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for FTD and is it functionally significant? | There are no SNPs within the gene RETSAT in Multi Ancestry Whole Brain Meta-analysis eQTL omic data that are significantly associated with FTD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RETSAT" AND Disease = "FTD" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 10... | [{'UUID': 'NDD_SMR_genes_all_update_text_1409697', 'topRSID': 'rs908302', 'Disease': 'FTD', 'Gene': 'RETSAT', 'p_SMR_multi': 0.1589445, 'p_HEIDI': 0.03661652, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1580 | Q67 | What is the top-associated SNP of the gene PICALM in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for PICALM in Whole Blood eQTL eQTLgen omic data for AD is rs7131120, which has a multi-SNP SMR p-value of 5.34e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PICALM" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498580', 'topRSID': 'rs7131120', 'Disease': 'AD', 'Gene': 'PICALM', 'p_SMR_multi': 5.340866e-09, 'p_HEIDI': 4.21145e-08, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Link... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1659 | Q67 | What is the top-associated SNP of the gene PAK6 in Cortex eQTL metaBrain omic data for PD and is it functionally significant? | There are no SNPs within the gene PAK6 in Cortex eQTL metaBrain omic data that are significantly associated with PD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PAK6" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1147505', 'topRSID': 'rs2253603', 'Disease': 'PD', 'Gene': 'PAK6', 'p_SMR_multi': 0.4500274, 'p_HEIDI': 0.7192633, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL metaBrain', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1116 | Q67 | What is the top-associated SNP of the gene RPS26P8 in Tibial Nerve eQTL omic data for PD and is it functionally significant? | The top-associated SNP for RPS26P8 in Tibial Nerve eQTL omic data for PD is rs55974014, which has a multi-SNP SMR p-value of 3.55e-13 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RPS26P8" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%tibial nerve eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1328929', 'topRSID': 'rs55974014', 'Disease': 'PD', 'Gene': 'RPS26P8', 'p_SMR_multi': 3.554859e-13, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Tibial Nerve', 'Omic_type': 'Tibial Nerve eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Dise... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.722 | Q67 | What is the top-associated SNP of the gene DKK3 in Whole Brain meta-analysis mQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene DKK3 in Whole Brain meta-analysis mQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "DKK3" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_371539', 'topRSID': 'rs2403565', 'Disease': 'LBD', 'Gene': 'DKK3', 'p_SMR_multi': 0.05256009, 'p_HEIDI': 0.5723883, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_3... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1247 | Q67 | What is the top-associated SNP of the gene LRRC37A in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for LRRC37A in Multi Ancestry Whole Brain Meta-analysis eQTL omic data for PSP is rs1981997, which has a multi-SNP SMR p-value of 6.79e-37 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "LRRC37A" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%multi ancestry whole brain meta-analysis eqtl%"
ORDER BY p_SMR_multi
LIMIT 1... | [{'UUID': 'NDD_SMR_genes_all_update_text_1444274', 'topRSID': 'rs1981997', 'Disease': 'PSP', 'Gene': 'LRRC37A', 'p_SMR_multi': 6.786299e-37, 'p_HEIDI': 5.605194e-45, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'Omic_type': 'Multi Ancestry Whole Brain Meta-analysis eQTL', 'func_sig': 'association meets significance thr... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1236 | Q67 | What is the top-associated SNP of the gene PRMT6 in Whole Blood mQTL omic data for AD and is it functionally significant? | There are no SNPs within the gene PRMT6 in Whole Blood mQTL omic data that are significantly associated with AD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PRMT6" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_653475', 'topRSID': 'rs115668827', 'Disease': 'AD', 'Gene': 'PRMT6', 'p_SMR_multi': 0.2517095, 'p_HEIDI': 0.07094327, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_653473', 'top... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1076 | Q67 | What is the top-associated SNP of the gene RP11-259G18.3 in Frontal Cortex BA9 eQTL omic data for PD and is it functionally significant? | The top-associated SNP for RP11-259G18.3 in Frontal Cortex BA9 eQTL omic data for PD is rs199456, which has a multi-SNP SMR p-value of 2.38e-11 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-259G18.3" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%frontal cortex ba9 eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1168837', 'topRSID': 'rs199456', 'Disease': 'PD', 'Gene': 'RP11-259G18.3', 'p_SMR_multi': 2.377632e-11, 'p_HEIDI': 0.005877049, 'Omic_tissue': 'Frontal Cortex', 'Omic_type': 'Frontal Cortex BA9 eQTL', 'func_sig': 'association meets significance threshold but shows signs of linka... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1907 | Q67 | What is the top-associated SNP of the gene CTD-2020K17.1 in Cerebellum eQTL omic data for PD and is it functionally significant? | The top-associated SNP for CTD-2020K17.1 in Cerebellum eQTL omic data for PD is rs62063276, which has a multi-SNP SMR p-value of 8.99e-08 and a HEIDI of 0.81, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CTD-2020K17.1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%cerebellum eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1710336', 'topRSID': 'rs62063276', 'Disease': 'PD', 'Gene': 'CTD-2020K17.1', 'p_SMR_multi': 8.988243e-08, 'p_HEIDI': 0.8132973, 'Omic_tissue': 'Cerebellum', 'Omic_type': 'Cerebellum eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.264 | Q67 | What is the top-associated SNP of the gene SPPL2C in Prefrontal Cortex eQTL omic data for PD and is it functionally significant? | The top-associated SNP for SPPL2C in Prefrontal Cortex eQTL omic data for PD is rs17577369, which has a multi-SNP SMR p-value of 1.30e-07 and a HEIDI of 0.02, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SPPL2C" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%prefrontal cortex eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242272', 'topRSID': 'rs17577369', 'Disease': 'PD', 'Gene': 'SPPL2C', 'p_SMR_multi': 1.300466e-07, 'p_HEIDI': 0.01842581, 'Omic_tissue': 'Prefrontal Cortex', 'Omic_type': 'Prefrontal Cortex eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1437 | Q67 | What is the top-associated SNP of the gene ARHGAP27 in Whole Blood mQTL omic data for PSP and is it functionally significant? | The top-associated SNP for ARHGAP27 in Whole Blood mQTL omic data for PSP is rs11012, which has a multi-SNP SMR p-value of 9.84e-21 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ARHGAP27" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041709', 'topRSID': 'rs11012', 'Disease': 'PSP', 'Gene': 'ARHGAP27', 'p_SMR_multi': 3.175631e-40, 'p_HEIDI': 2.761191e-07, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Di... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1339 | Q67 | What is the top-associated SNP of the gene MAPT in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT in Whole Brain meta-analysis mQTL omic data for PD is rs62063859, which has a multi-SNP SMR p-value of 6.79e-07 and a HEIDI of 0.11, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_491114', 'topRSID': 'rs17652121', 'Disease': 'PD', 'Gene': 'MAPT', 'p_SMR_multi': 4.729064e-14, 'p_HEIDI': 0.04416005, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_49... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.243 | Q67 | What is the top-associated SNP of the gene ABTB1 in Whole Blood eQTL GTEx omic data for PSP and is it functionally significant? | There are no SNPs within the gene ABTB1 in Whole Blood eQTL GTEx omic data that are significantly associated with PSP, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ABTB1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1681924', 'topRSID': 'rs2336408', 'Disease': 'PSP', 'Gene': 'ABTB1', 'p_SMR_multi': 0.8533904, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1010 | Q67 | What is the top-associated SNP of the gene ZFP57 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for ZFP57 in Whole Blood mQTL omic data for AD is rs2747429, which has a multi-SNP SMR p-value of 2.31e-06 and a HEIDI of 0.25, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ZFP57" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619934', 'topRSID': 'rs2747429', 'Disease': 'AD', 'Gene': 'ZFP57', 'p_SMR_multi': 2.309027e-06, 'p_HEIDI': 0.2518906, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_619954', 'topRSID... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.685 | Q67 | What is the top-associated SNP of the gene CRHR1 in Tibial Nerve eQTL omic data for PD and is it functionally significant? | The top-associated SNP for CRHR1 in Tibial Nerve eQTL omic data for PD is rs8070723, which has a multi-SNP SMR p-value of 7.72e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CRHR1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%tibial nerve eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1328931', 'topRSID': 'rs8070723', 'Disease': 'PD', 'Gene': 'CRHR1', 'p_SMR_multi': 7.718008e-09, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Tibial Nerve', 'Omic_type': 'Tibial Nerve eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequi... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1268 | Q67 | What is the top-associated SNP of the gene KANSL1 in Whole Blood mQTL omic data for PSP and is it functionally significant? | The top-associated SNP for KANSL1 in Whole Blood mQTL omic data for PSP is rs415430, which has a multi-SNP SMR p-value of 1.72e-11 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KANSL1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041761', 'topRSID': 'rs169201', 'Disease': 'PSP', 'Gene': 'KANSL1', 'p_SMR_multi': 3.489683e-40, 'p_HEIDI': 3.497522e-13, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Dis... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1475 | Q67 | What is the top-associated SNP of the gene BIN1 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for BIN1 in Whole Blood mQTL omic data for AD is rs934826, which has a multi-SNP SMR p-value of 6.86e-14 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "BIN1" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_631119', 'topRSID': 'rs58402148', 'Disease': 'AD', 'Gene': 'BIN1', 'p_SMR_multi': 2.405281e-31, 'p_HEIDI': 3.999879e-37, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Diseq... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1502 | Q67 | What is the top-associated SNP of the gene HYAL3 in Whole Blood eQTL GTEx omic data for ALS and is it functionally significant? | There are no SNPs within the gene HYAL3 in Whole Blood eQTL GTEx omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "HYAL3" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1655163', 'topRSID': 'rs13100173', 'Disease': 'ALS', 'Gene': 'HYAL3', 'p_SMR_multi': 0.2142309, 'p_HEIDI': 0.1718437, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.370 | Q67 | What is the top-associated SNP of the gene MAPT-AS1 in Skeletal Muscle eQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT-AS1 in Skeletal Muscle eQTL omic data for PD is rs1879585, which has a multi-SNP SMR p-value of 4.80e-09 and a HEIDI of 0.08, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT-AS1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1370544', 'topRSID': 'rs1879585', 'Disease': 'PD', 'Gene': 'MAPT-AS1', 'p_SMR_multi': 4.799737e-09, 'p_HEIDI': 0.08302246, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1009 | Q67 | What is the top-associated SNP of the gene IGSF9B in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for IGSF9B in Whole Blood mQTL omic data for PD is rs36086419, which has a multi-SNP SMR p-value of 1.56e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "IGSF9B" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_961101', 'topRSID': 'rs3802920', 'Disease': 'PD', 'Gene': 'IGSF9B', 'p_SMR_multi': 1.22563e-10, 'p_HEIDI': 0.0001625568, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Diseq... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1239 | Q67 | What is the top-associated SNP of the gene FAM209B in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for FAM209B in Whole Blood eQTL eQTLgen omic data for AD is rs56104586, which has a multi-SNP SMR p-value of 5.44e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "FAM209B" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504675', 'topRSID': 'rs56104586', 'Disease': 'AD', 'Gene': 'FAM209B', 'p_SMR_multi': 5.439246e-07, 'p_HEIDI': 0.0001051177, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linkage/ L... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.595 | Q67 | What is the top-associated SNP of the gene MARK4 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for MARK4 in Whole Blood mQTL omic data for AD is rs10409232, which has a multi-SNP SMR p-value of 1.73e-11 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MARK4" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637449', 'topRSID': 'rs10409232', 'Disease': 'AD', 'Gene': 'MARK4', 'p_SMR_multi': 1.728605e-11, 'p_HEIDI': 2.720626e-14, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Dise... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.728 | Q67 | What is the top-associated SNP of the gene ARL17A in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for ARL17A in Whole Blood mQTL omic data for PD is rs17698176, which has a multi-SNP SMR p-value of 1.00e-10 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ARL17A" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948920', 'topRSID': 'rs17698176', 'Disease': 'PD', 'Gene': 'ARL17A', 'p_SMR_multi': 1.000148e-10, 'p_HEIDI': 7.909193e-11, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Dis... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.486 | Q67 | What is the top-associated SNP of the gene WDR43 in Whole Brain meta-analysis mQTL omic data for ALS and is it functionally significant? | There are no SNPs within the gene WDR43 in Whole Brain meta-analysis mQTL omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "WDR43" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_139680', 'topRSID': 'rs4666127', 'Disease': 'ALS', 'Gene': 'WDR43', 'p_SMR_multi': 0.0558827, 'p_HEIDI': 0.7280888, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_1... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.573 | Q67 | What is the top-associated SNP of the gene RP11-960L18.1 in Whole Blood eQTL GTEx omic data for AD and is it functionally significant? | The top-associated SNP for RP11-960L18.1 in Whole Blood eQTL GTEx omic data for AD is rs12446759, which has a multi-SNP SMR p-value of 1.70e-07 and a HEIDI of 0.33, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-960L18.1" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1652197', 'topRSID': 'rs12446759', 'Disease': 'AD', 'Gene': 'RP11-960L18.1', 'p_SMR_multi': 1.702651e-07, 'p_HEIDI': 0.3347655, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.74 | Q67 | What is the top-associated SNP of the gene RP11-707O23.5 in Skeletal Muscle eQTL omic data for AD and is it functionally significant? | The top-associated SNP for RP11-707O23.5 in Skeletal Muscle eQTL omic data for AD is rs55974014, which has a multi-SNP SMR p-value of 1.25e-06 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-707O23.5" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1343150', 'topRSID': 'rs55974014', 'Disease': 'AD', 'Gene': 'RP11-707O23.5', 'p_SMR_multi': 1.245942e-06, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.635 | Q67 | What is the top-associated SNP of the gene A4GALT in Cortex eQTL metaBrain omic data for LBD and is it functionally significant? | There are no SNPs within the gene A4GALT in Cortex eQTL metaBrain omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "A4GALT" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1133776', 'topRSID': 'rs2143918', 'Disease': 'LBD', 'Gene': 'A4GALT', 'p_SMR_multi': 0.3150668, 'p_HEIDI': 0.8274714, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL metaBrain', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.262 | Q67 | What is the top-associated SNP of the gene SFXN5 in Whole Blood mQTL omic data for AD and is it functionally significant? | There are no SNPs within the gene SFXN5 in Whole Blood mQTL omic data that are significantly associated with AD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SFXN5" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_629942', 'topRSID': 'rs56088054', 'Disease': 'AD', 'Gene': 'SFXN5', 'p_SMR_multi': 0.07249272, 'p_HEIDI': 0.7594645, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_629941', 'topR... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.52 | Q67 | What is the top-associated SNP of the gene RP11-259G18.1 in Whole Blood eQTL eQTLgen omic data for PD and is it functionally significant? | The top-associated SNP for RP11-259G18.1 in Whole Blood eQTL eQTLgen omic data for PD is rs2532233, which has a multi-SNP SMR p-value of 4.37e-15 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "RP11-259G18.1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564788', 'topRSID': 'rs2532233', 'Disease': 'PD', 'Gene': 'RP11-259G18.1', 'p_SMR_multi': 4.366554e-15, 'p_HEIDI': 1.806015e-06, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linka... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.201 | Q67 | What is the top-associated SNP of the gene CEACAM19 in Hypothalamus eQTL omic data for AD and is it functionally significant? | The top-associated SNP for CEACAM19 in Hypothalamus eQTL omic data for AD is rs714948, which has a multi-SNP SMR p-value of 4.16e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CEACAM19" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%hypothalamus eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1454558', 'topRSID': 'rs714948', 'Disease': 'AD', 'Gene': 'CEACAM19', 'p_SMR_multi': 4.158688e-07, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Hypothalamus', 'Omic_type': 'Hypothalamus eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Diseq... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.432 | Q67 | What is the top-associated SNP of the gene ZNF668 in Whole Blood eQTL GTEx omic data for PD and is it functionally significant? | The top-associated SNP for ZNF668 in Whole Blood eQTL GTEx omic data for PD is rs4889530, which has a multi-SNP SMR p-value of 1.74e-07 and a HEIDI of 0.01, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ZNF668" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1679160', 'topRSID': 'rs4889530', 'Disease': 'PD', 'Gene': 'ZNF668', 'p_SMR_multi': 1.736465e-07, 'p_HEIDI': 0.01113564, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1563 | Q67 | What is the top-associated SNP of the gene STAG3 in Cerebellum eQTL omic data for AD and is it functionally significant? | The top-associated SNP for STAG3 in Cerebellum eQTL omic data for AD is rs34130487, which has a multi-SNP SMR p-value of 1.18e-09 and a HEIDI of 0.41, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "STAG3" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%cerebellum eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1687933', 'topRSID': 'rs34130487', 'Disease': 'AD', 'Gene': 'STAG3', 'p_SMR_multi': 1.184878e-09, 'p_HEIDI': 0.406217, 'Omic_tissue': 'Cerebellum', 'Omic_type': 'Cerebellum eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.336 | Q67 | What is the top-associated SNP of the gene PPIG in Whole Brain meta-analysis mQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene PPIG in Whole Brain meta-analysis mQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PPIG" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_329501', 'topRSID': 'rs2592807', 'Disease': 'LBD', 'Gene': 'PPIG', 'p_SMR_multi': 0.2573367, 'p_HEIDI': 0.2072834, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_32... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1557 | Q67 | What is the top-associated SNP of the gene GPC2 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for GPC2 in Whole Blood mQTL omic data for AD is rs3779045, which has a multi-SNP SMR p-value of 1.22e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GPC2" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585980', 'topRSID': 'rs3779045', 'Disease': 'AD', 'Gene': 'GPC2', 'p_SMR_multi': 1.221726e-08, 'p_HEIDI': 0.005607984, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequi... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1539 | Q67 | What is the top-associated SNP of the gene GAK in Whole Blood mQTL omic data for PD and is it functionally significant? | The top-associated SNP for GAK in Whole Blood mQTL omic data for PD is rs3775130, which has a multi-SNP SMR p-value of 1.48e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "GAK" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996273', 'topRSID': 'rs12651271', 'Disease': 'PD', 'Gene': 'GAK', 'p_SMR_multi': 6.180527e-09, 'p_HEIDI': 3.619298e-07, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.426 | Q67 | What is the top-associated SNP of the gene CLTA in Whole Brain meta-analysis mQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene CLTA in Whole Brain meta-analysis mQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CLTA" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_362988', 'topRSID': 'rs35651477', 'Disease': 'LBD', 'Gene': 'CLTA', 'p_SMR_multi': 0.4366226, 'p_HEIDI': 0.1580673, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_3... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.637 | Q67 | What is the top-associated SNP of the gene CPSF3 in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for CPSF3 in Whole Blood eQTL eQTLgen omic data for AD is rs7561588, which has a multi-SNP SMR p-value of 1.24e-06 and a HEIDI of 0.07, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "CPSF3" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1491392', 'topRSID': 'rs7561588', 'Disease': 'AD', 'Gene': 'CPSF3', 'p_SMR_multi': 1.236226e-06, 'p_HEIDI': 0.06535516, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.941 | Q67 | What is the top-associated SNP of the gene STAG3 in Hippocampus eQTL omic data for AD and is it functionally significant? | The top-associated SNP for STAG3 in Hippocampus eQTL omic data for AD is rs34130487, which has a multi-SNP SMR p-value of 2.18e-07 and a HEIDI of 0.55, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "STAG3" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%hippocampus eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1377707', 'topRSID': 'rs34130487', 'Disease': 'AD', 'Gene': 'STAG3', 'p_SMR_multi': 2.179524e-07, 'p_HEIDI': 0.5534318, 'Omic_tissue': 'Hippocampus', 'Omic_type': 'Hippocampus eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.993 | Q67 | What is the top-associated SNP of the gene SNCA in Whole Blood eQTL GTEx omic data for PD and is it functionally significant? | The top-associated SNP for SNCA in Whole Blood eQTL GTEx omic data for PD is rs2736989, which has a multi-SNP SMR p-value of 1.75e-06 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "SNCA" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1675742', 'topRSID': 'rs2736989', 'Disease': 'PD', 'Gene': 'SNCA', 'p_SMR_multi': 1.746399e-06, 'p_HEIDI': 9.025993e-05, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.868 | Q67 | What is the top-associated SNP of the gene DND1P1 in Cerebellar Hemisphere eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for DND1P1 in Cerebellar Hemisphere eQTL omic data for PSP is rs1635291, which has a multi-SNP SMR p-value of 1.17e-10 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "DND1P1" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%cerebellar hemisphere eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1194212', 'topRSID': 'rs1635291', 'Disease': 'PSP', 'Gene': 'DND1P1', 'p_SMR_multi': 1.174317e-10, 'p_HEIDI': 1.003004e-05, 'Omic_tissue': 'Cerebellar Hemisphere', 'Omic_type': 'Cerebellar Hemisphere eQTL', 'func_sig': 'association meets significance threshold but shows signs of... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1951 | Q67 | What is the top-associated SNP of the gene PLEKHM1 in Whole Blood eQTL eQTLgen omic data for PD and is it functionally significant? | The top-associated SNP for PLEKHM1 in Whole Blood eQTL eQTLgen omic data for PD is rs55663797, which has a multi-SNP SMR p-value of 1.78e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PLEKHM1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564775', 'topRSID': 'rs55663797', 'Disease': 'PD', 'Gene': 'PLEKHM1', 'p_SMR_multi': 1.782097e-08, 'p_HEIDI': 1.674159e-09, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'association meets significance threshold but shows signs of linkage/ L... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.558 | Q67 | What is the top-associated SNP of the gene MAPT in Whole Blood mQTL omic data for PSP and is it functionally significant? | The top-associated SNP for MAPT in Whole Blood mQTL omic data for PSP is rs169201, which has a multi-SNP SMR p-value of 3.19e-44 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041740', 'topRSID': 'rs169201', 'Disease': 'PSP', 'Gene': 'MAPT', 'p_SMR_multi': 3.1929999999999995e-44, 'p_HEIDI': 3.11336e-12, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Link... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.433 | Q67 | What is the top-associated SNP of the gene ARL17A in Skeletal Muscle eQTL omic data for AD and is it functionally significant? | The top-associated SNP for ARL17A in Skeletal Muscle eQTL omic data for AD is rs2732650, which has a multi-SNP SMR p-value of 2.76e-06 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ARL17A" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1343162', 'topRSID': 'rs2732650', 'Disease': 'AD', 'Gene': 'ARL17A', 'p_SMR_multi': 2.755616e-06, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1777 | Q67 | What is the top-associated SNP of the gene IQSEC1 in Whole Blood mQTL omic data for ALS and is it functionally significant? | There are no SNPs within the gene IQSEC1 in Whole Blood mQTL omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "IQSEC1" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_677907', 'topRSID': 'rs526658', 'Disease': 'ALS', 'Gene': 'IQSEC1', 'p_SMR_multi': 0.0786088, 'p_HEIDI': 0.2593695, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_677908', 'topRS... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1834 | Q67 | What is the top-associated SNP of the gene TAP2 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for TAP2 in Whole Blood mQTL omic data for AD is rs4148874, which has a multi-SNP SMR p-value of 5.53e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TAP2" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621739', 'topRSID': 'rs241437', 'Disease': 'AD', 'Gene': 'TAP2', 'p_SMR_multi': 8.321216e-09, 'p_HEIDI': 0.003695236, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequil... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1977 | Q67 | What is the top-associated SNP of the gene ARL17A in Hippocampus eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for ARL17A in Hippocampus eQTL omic data for PSP is rs393152, which has a multi-SNP SMR p-value of 1.18e-09 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ARL17A" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%hippocampus eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_33475', 'topRSID': 'rs393152', 'Disease': 'PSP', 'Gene': 'ARL17A', 'p_SMR_multi': 4.356716e-15, 'p_HEIDI': 6.27192e-08, 'Omic_tissue': 'Hippocampus', 'Omic_type': 'Hippocampus eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequ... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1506 | Q67 | What is the top-associated SNP of the gene MAPT-AS1 in Whole Blood mQTL omic data for AD and is it functionally significant? | The top-associated SNP for MAPT-AS1 in Whole Blood mQTL omic data for AD is rs113790915, which has a multi-SNP SMR p-value of 1.49e-06 and a HEIDI of 0.04, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT-AS1" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_591182', 'topRSID': 'rs112310745', 'Disease': 'AD', 'Gene': 'MAPT-AS1', 'p_SMR_multi': 7.625542e-07, 'p_HEIDI': 0.02525318, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_591183', 't... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1622 | Q67 | What is the top-associated SNP of the gene FLJ27365 in Whole Blood mQTL omic data for ALS and is it functionally significant? | There are no SNPs within the gene FLJ27365 in Whole Blood mQTL omic data that are significantly associated with ALS, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "FLJ27365" AND Disease = "ALS" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_677077', 'topRSID': 'rs7289457', 'Disease': 'ALS', 'Gene': 'FLJ27365', 'p_SMR_multi': 0.06053811, 'p_HEIDI': 0.06949291, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_677076', '... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.404 | Q67 | What is the top-associated SNP of the gene TREML2 in Whole Blood eQTL eQTLgen omic data for AD and is it functionally significant? | The top-associated SNP for TREML2 in Whole Blood eQTL eQTLgen omic data for AD is rs9471495, which has a multi-SNP SMR p-value of 3.86e-08 and a HEIDI of 0.05, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "TREML2" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494869', 'topRSID': 'rs9471495', 'Disease': 'AD', 'Gene': 'TREML2', 'p_SMR_multi': 3.856316e-08, 'p_HEIDI': 0.05478847, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL eQTLgen', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1791 | Q67 | What is the top-associated SNP of the gene LRRC37A2 in Cortex eQTL metaBrain omic data for PSP and is it functionally significant? | The top-associated SNP for LRRC37A2 in Cortex eQTL metaBrain omic data for PSP is rs7225002, which has a multi-SNP SMR p-value of 6.07e-41 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "LRRC37A2" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154400', 'topRSID': 'rs7225002', 'Disease': 'PSP', 'Gene': 'LRRC37A2', 'p_SMR_multi': 6.06628e-41, 'p_HEIDI': 2.657098e-31, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL metaBrain', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage D... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.195 | Q67 | What is the top-associated SNP of the gene MAPT in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT in Whole Brain meta-analysis mQTL omic data for PD is rs62063296, which has a multi-SNP SMR p-value of 9.01e-12 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_491114', 'topRSID': 'rs17652121', 'Disease': 'PD', 'Gene': 'MAPT', 'p_SMR_multi': 4.729064e-14, 'p_HEIDI': 0.04416005, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_49... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1281 | Q67 | What is the top-associated SNP of the gene C1orf198 in Whole Blood mQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene C1orf198 in Whole Blood mQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "C1orf198" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_881983', 'topRSID': 'rs12141900', 'Disease': 'LBD', 'Gene': 'C1orf198', 'p_SMR_multi': 0.4617173, 'p_HEIDI': 0.1448577, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'not functionally significant'}, {'UUID': 'NDD_SMR_genes_all_update_text_881981', 't... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1381 | Q67 | What is the top-associated SNP of the gene KAT8 in Cortex eQTL GTEx omic data for PD and is it functionally significant? | The top-associated SNP for KAT8 in Cortex eQTL GTEx omic data for PD is rs1060506, which has a multi-SNP SMR p-value of 6.68e-07 and a HEIDI of 0.04, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KAT8" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%cortex eqtl gtex%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1262000', 'topRSID': 'rs1060506', 'Disease': 'PD', 'Gene': 'KAT8', 'p_SMR_multi': 6.677719e-07, 'p_HEIDI': 0.03828886, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL GTEx', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.677 | Q67 | What is the top-associated SNP of the gene KAT8 in Hypothalamus eQTL omic data for PD and is it functionally significant? | The top-associated SNP for KAT8 in Hypothalamus eQTL omic data for PD is rs61162043, which has a multi-SNP SMR p-value of 1.81e-06 and a HEIDI of 0.21, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KAT8" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%hypothalamus eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1462783', 'topRSID': 'rs61162043', 'Disease': 'PD', 'Gene': 'KAT8', 'p_SMR_multi': 1.814967e-06, 'p_HEIDI': 0.2130376, 'Omic_tissue': 'Hypothalamus', 'Omic_type': 'Hypothalamus eQTL', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.795 | Q67 | What is the top-associated SNP of the gene KAT8 in Prefrontal Cortex eQTL omic data for PD and is it functionally significant? | The top-associated SNP for KAT8 in Prefrontal Cortex eQTL omic data for PD is rs9972727, which has a multi-SNP SMR p-value of 8.64e-08 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "KAT8" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%prefrontal cortex eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1241727', 'topRSID': 'rs9972727', 'Disease': 'PD', 'Gene': 'KAT8', 'p_SMR_multi': 8.642794e-08, 'p_HEIDI': 0.003502415, 'Omic_tissue': 'Prefrontal Cortex', 'Omic_type': 'Prefrontal Cortex eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Li... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1463 | Q67 | What is the top-associated SNP of the gene ACE in Cortex eQTL metaBrain omic data for AD and is it functionally significant? | The top-associated SNP for ACE in Cortex eQTL metaBrain omic data for AD is rs4291, which has a multi-SNP SMR p-value of 1.39e-08 and a HEIDI of 0.27, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ACE" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1106908', 'topRSID': 'rs4291', 'Disease': 'AD', 'Gene': 'ACE', 'p_SMR_multi': 1.386269e-08, 'p_HEIDI': 0.2721482, 'Omic_tissue': 'Cortex', 'Omic_type': 'Cortex eQTL metaBrain', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1457 | Q67 | What is the top-associated SNP of the gene MAPT-AS1 in Whole Brain meta-analysis mQTL omic data for PD and is it functionally significant? | The top-associated SNP for MAPT-AS1 in Whole Brain meta-analysis mQTL omic data for PD is rs3785884, which has a multi-SNP SMR p-value of 1.21e-11 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MAPT-AS1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_491096', 'topRSID': 'rs56280951', 'Disease': 'PD', 'Gene': 'MAPT-AS1', 'p_SMR_multi': 3.97087e-15, 'p_HEIDI': 0.001150121, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkag... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.144 | Q67 | What is the top-associated SNP of the gene PLEKHM1 in Cerebellum eQTL omic data for PD and is it functionally significant? | The top-associated SNP for PLEKHM1 in Cerebellum eQTL omic data for PD is rs62065453, which has a multi-SNP SMR p-value of 8.05e-13 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "PLEKHM1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%cerebellum eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_19645', 'topRSID': 'rs62065453', 'Disease': 'PD', 'Gene': 'PLEKHM1', 'p_SMR_multi': 8.047881e-13, 'p_HEIDI': -9999.0, 'Omic_tissue': 'Cerebellum', 'Omic_type': 'Cerebellum eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequilib... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1188 | Q67 | What is the top-associated SNP of the gene LRRC37A2 in Liver eQTL omic data for PSP and is it functionally significant? | The top-associated SNP for LRRC37A2 in Liver eQTL omic data for PSP is rs1981997, which has a multi-SNP SMR p-value of 3.74e-14 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "LRRC37A2" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%liver eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1478193', 'topRSID': 'rs1981997', 'Disease': 'PSP', 'Gene': 'LRRC37A2', 'p_SMR_multi': 3.741471e-14, 'p_HEIDI': 1.564571e-09, 'Omic_tissue': 'Liver', 'Omic_type': 'Liver eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage Disequilibri... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.3 | Q67 | What is the top-associated SNP of the gene ARL17A in Whole Blood mQTL omic data for PSP and is it functionally significant? | The top-associated SNP for ARL17A in Whole Blood mQTL omic data for PSP is rs17692129, which has a multi-SNP SMR p-value of 9.28e-23 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "ARL17A" AND Disease = "PSP" AND LOWER(Omic_type) LIKE "%whole blood mqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041774', 'topRSID': 'rs17692129', 'Disease': 'PSP', 'Gene': 'ARL17A', 'p_SMR_multi': 9.278724e-23, 'p_HEIDI': 2.813254e-12, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Linkage D... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.743 | Q67 | What is the top-associated SNP of the gene BHMT2 in Whole Brain eQTL omic data for LBD and is it functionally significant? | There are no SNPs within the gene BHMT2 in Whole Brain eQTL omic data that are significantly associated with LBD, indicating that it is not functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "BHMT2" AND Disease = "LBD" AND LOWER(Omic_type) LIKE "%whole brain eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1628952', 'topRSID': 'rs486580', 'Disease': 'LBD', 'Gene': 'BHMT2', 'p_SMR_multi': 0.9517653, 'p_HEIDI': 0.1098057, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain eQTL', 'func_sig': 'not functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1871 | Q67 | What is the top-associated SNP of the gene MMRN1 in Substantia nigra eQTL omic data for PD and is it functionally significant? | The top-associated SNP for MMRN1 in Substantia nigra eQTL omic data for PD is rs75943295, which has a multi-SNP SMR p-value of 1.61e-07 but is not functionally significant as the association meets significance threshold but shows signs of linkage/ Linkage Disequilibrium. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "MMRN1" AND Disease = "PD" AND LOWER(Omic_type) LIKE "%substantia nigra eqtl%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1450943', 'topRSID': 'rs75943295', 'Disease': 'PD', 'Gene': 'MMRN1', 'p_SMR_multi': 1.608395e-07, 'p_HEIDI': 0.00737515, 'Omic_tissue': 'Substantia nigra', 'Omic_type': 'Substantia nigra eQTL', 'func_sig': 'association meets significance threshold but shows signs of linkage/ Lin... | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
Q67.1516 | Q67 | What is the top-associated SNP of the gene AC012146.7 in Nucleus Accumbens Basal Ganglia omic data for AD and is it functionally significant? | The top-associated SNP for AC012146.7 in Nucleus Accumbens Basal Ganglia omic data for AD is rs56197642, which has a multi-SNP SMR p-value of 1.15e-06 and a HEIDI of 0.2, indicating that it is functionally significant. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type, func_sig
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = "AC012146.7" AND Disease = "AD" AND LOWER(Omic_type) LIKE "%nucleus accumbens basal ganglia%"
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1717291', 'topRSID': 'rs56197642', 'Disease': 'AD', 'Gene': 'AC012146.7', 'p_SMR_multi': 1.151959e-06, 'p_HEIDI': 0.1955708, 'Omic_tissue': 'Nucleus Accumbens Basal', 'Omic_type': 'Nucleus Accumbens Basal Ganglia', 'func_sig': 'functionally significant'}] | general | Select, Similarity Search, Multi-Filter, Order By | Functional Significance |
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