0 stringlengths 12 494 | embeddings listlengths 384 384 |
|---|---|
chromosome.\tSuch\tsequences\tare\tcalled\t\nintervening\tsequences\n\tand\tcompose\tthe\tmajority\n\tof\tthe\nDNA\tin\thumans.\tThese\tsequences\tdo\tnot\tcode\tfor\tproteins,\tbut\tthey\tare\tnot\t“junk\tDNA”\tas\toriginally\nthought.\tInstead,\tthey\tperform\tstructural\tand\tregulatory\tfunctions,\tsuch\tas\tcontro... | [
-0.03288748860359192,
-0.04349832981824875,
0.024448856711387634,
-0.05919909477233887,
-0.11252574622631073,
0.014201294630765915,
0.03717133775353432,
0.023822052404284477,
-0.017852457240223885,
0.09127254784107208,
0.13006295263767242,
-0.049698829650878906,
-0.012664229609072208,
0.02... |
and\thow\tmuch\tof\ta\tprotein\tis\tproduced.\nThe\tlarge\tamount\tof\tgenetic\tmaterial\tin\tthe\tnucleus\tis\tdistributed\tamong\tmultiple\t\nchromosomes\n,\nwhich\tare\tformed\tby\twrapping\tDNA\ttightly\taround\tspecific\n\tproteins\tcalled\t\nhistones\n.\tHuman\tbeings\nhave\t23\tpairs\tof\tchromosomes,\t22\t\naut... | [
-0.017491761595010757,
-0.0697685033082962,
0.02465120702981949,
-0.03375636041164398,
-0.06459740549325943,
0.02717219851911068,
0.05829322338104248,
-0.009788312949240208,
0.02181542105972767,
0.08371683210134506,
0.06783436983823776,
-0.029239628463983536,
0.08000453561544418,
0.0379285... |
autosomes\n,\tand\t2\t\nsex\tchromosomes\n.\tOne\tcopy\tof\teach\tmember\nof\ta\tpair\tcomes\tfrom\tthe\tmother\tand\tthe\tother\tfrom\tthe\tfather.\tFemales\thave\ttwo\tX\tchromosomes;\nmales\thave\tone\tX\tand\tone\tY\tchromosome.\tThe\tnucleus\tof\teach\thuman\tcell\tcontains\tall\t46\nchromosomes.\nGene\texpression... | [
-0.028629636391997337,
-0.03045133873820305,
0.03800496459007263,
-0.04176115617156029,
-0.14059185981750488,
-0.013929220847785473,
0.09430602192878723,
-0.02614559605717659,
0.013658185489475727,
0.06723004579544067,
0.09724864363670349,
-0.03128468990325928,
0.047104690223932266,
0.0199... |
To\tinitiate\tthe\tprocess\n\tof\tdecoding\tthe\tDNA,\tthe\tcondensed\tchromosomes\thousing\tthe\tgenes\tfirst\nmust\topen\t(decondense)\tto\tallow\taccess\tto\tthe\tinformation\tin\tthe\tDNA\tnucleotide\tsequence.\tA\ncommon\tmechanism\temployed\tis\tthe\tcovalent\tattachment\tof\tacetyl\tgroups\tto\tthe\thistone\tpro... | [
-0.011148831807076931,
-0.0586552694439888,
0.02542280964553356,
-0.051304060965776443,
-0.14162318408489227,
-0.01004608441144228,
0.04335775226354599,
-0.01832469366490841,
0.014887652359902859,
0.12296983599662781,
0.08807573467493057,
-0.04591769725084305,
0.011875317431986332,
0.03690... |
associated\twith\tthe\tchromosomes.\tThis\taction\trelaxes\tthe\tDNA\tand\tmakes\tit\taccessible\tto\tthe\nenzymes\tinvolved\tin\t\ntranscription\n\t(the\tdecoding\n\tprocess).\tInformation\tdecoding\tinvolves\ntranscription\tby\tribonucleic\tacid\t(RNA)\tpolymerase\tinto\tpre-messenger\tRNA\t(pre-mRNA)\tand | [
-0.028412632644176483,
-0.061468154191970825,
-0.015635736286640167,
-0.04708148166537285,
-0.10456572473049164,
0.027545176446437836,
0.040903471410274506,
0.02515152283012867,
0.021500935778021812,
0.06048388406634331,
0.11354652047157288,
-0.030473893508315086,
-0.018201207742094994,
0.... |
subsequent\ttranslation\tof\tmRNA\tinto\tthe\tamino\tacid\tsequence\tof\tthe\tprotein\taccording\tto\ta\tuniversal\ngenetic\tcode.\tThe\tarchitecture\tof\ta\tgene\ttypically\tincludes\ta\tpromoter\tregion,\twhere\tthe\tRNA\npolymerase\tattaches\tand\ta\t\ncoding\tregion\n\t(also\tcalled\ta\t“structural\tregion”)\n\ttha... | [
0.0019692035857588053,
-0.047893743962049484,
0.050034645944833755,
-0.03540628030896187,
-0.12068726867437363,
0.016216222196817398,
0.07504752278327942,
-0.039103616029024124,
0.07964368909597397,
0.03995776176452637,
0.11572273075580597,
-0.012230133637785912,
0.038019660860300064,
0.01... |
coding\tregion\n\t(also\tcalled\ta\t“structural\tregion”)\n\tthat\tcontains\tthe\nencoded\tinformation\tfor\tsynthesizing\tthat\tgene’s\tprotein.\tWithin\tthe\tcoding\tregion\tare\tsequences\tof\nnucleotides\tcalled\t\nexons\n\tthat\tcorrespond\tto\tthe\torder\tof\tthe\tamino\tacids\tin\tthe\tgene’s\tprotein\nproduct.\... | [
-0.06972301751375198,
-0.030347054824233055,
-0.015764331445097923,
-0.04320410266518593,
-0.10576822608709335,
-0.006947092246264219,
0.0725807473063469,
0.015058213844895363,
0.04930663853883743,
0.056089576333761215,
0.06537481397390366,
-0.023334424942731857,
0.026270465925335884,
0.02... |
product.\tThe\tcoding\tregion\talso\tcontains\t\nintrons\n\t(sequences\tthat\tare\tinterspersed\tbetween\texons\nand\tdo\tnot\tcode\tfor\tamino\tacids\tneeded\tfor\tsynthesizing\tproteins).\nUpstream\tfrom\tthe\tpromoter\n\tregion\tis\tthe\t\nregulatory\tregion\n\tthat\tcontrols\tthe\tability\tof\tthe | [
-0.03630112111568451,
-0.050095345824956894,
-0.0034215266350656748,
-0.08450885117053986,
-0.09100925177335739,
0.017435221001505852,
0.11315571516752243,
0.005882841069251299,
0.04898595064878464,
0.016756154596805573,
0.07835152745246887,
-0.01185893826186657,
0.04413105174899101,
0.028... |
region\tis\tthe\t\nregulatory\tregion\n\tthat\tcontrols\tthe\tability\tof\tthe\npolymerase\tto\tattach\tto\tthe\tpromoter,\tthereby\tinfluencing\twhether\ttranscription\toccurs.\tWithin\tthis\nregion\tare\t\nresponse\telements\n,\tDNA\tsequences\tthat\tserve\tas\tbinding\tsites\tfor\tregulatory\tproteins\nsuch\tas\t\nt... | [
0.03966278210282326,
-0.07079963386058807,
0.045952677726745605,
-0.08541316539049149,
-0.1017664298415184,
0.007100286893546581,
0.057231735438108444,
-0.015024772845208645,
0.05273391678929329,
0.07918234914541245,
0.09067713469266891,
-0.011328546330332756,
0.04986261576414108,
0.038552... |
such\tas\t\ntranscription\tfactors\n\tand\ttheir\tbound\t\nligands\n.\tThe\tbinding\tof\ttranscription\tfactors\ntriggers\tthe\trecruitment\tof\tadditional\tproteins\n\tto\tform\ta\tprotein\tcomplex\tthat\tin\tturn\tchanges\tthe\nexpression\tof\tthat\tgene\tby\tchanging\tthe\tconformation\tof\tthe\tpromoter\tregion,\ti... | [
0.005835163872689009,
-0.0421842560172081,
0.03599773719906807,
-0.03272271528840065,
-0.099288709461689,
0.06087957322597504,
0.08040878921747208,
-0.029234981164336205,
0.044361039996147156,
0.06984643638134003,
0.08016020059585571,
-0.03488831967115402,
0.06408625096082687,
0.0397187769... |
decreasing\tthe\tability\tof\tRNA\tpolymerase\tto\tattach\tand\ttranscribe\t(express)\tthe\tgene.\tThe\tarray\tof\nresponse\telements\twithin\tthe\tpromoter\tregion\tcan\tbe\tcomplex,\tallowing\tfor\tthe\tbinding\tof\tmultiple\ntranscription\tfactors\tthat\tin\tturn\tfine-tune\tthe\tcontrol\n\tof\tgene\texpression.\tIt... | [
-0.00009504852641839534,
-0.035952128469944,
0.03843153268098831,
-0.042177729308605194,
-0.10085023939609528,
-0.016266267746686935,
0.07878662645816803,
0.021805262193083763,
0.05845678970217705,
0.04635348916053772,
0.03078155592083931,
0.015415320172905922,
0.062023114413022995,
-0.008... |
of\tgene\texpression.\tIt\tis\tthrough\tthe\tbinding\tof\ntranscription\tfactors\tto\tresponse\telements\tthat\tenvironmental\tfactors\tsuch\tas\tthe\tbioactive\ncomponents\tin\tfood\tessentially\t“talk”\tto\ta\tgene,\tconveying\tinformation\tthat\tmore\tor\tless\tof\tits\nprotein\tproduct\tis\tneeded. | [
0.03307921066880226,
-0.06576470285654068,
0.07359954714775085,
-0.02863720990717411,
-0.08887159079313278,
0.02364525943994522,
0.09650524705648422,
-0.013665654696524143,
0.011952459812164307,
0.0875152200460434,
0.06568960100412369,
-0.06932266056537628,
0.03065520152449608,
0.027327012... |
protein\tproduct\tis\tneeded.\nOnce\ttranscribed,\tthe\tpre-mRNA\tmust\tbe\tprocessed\t(posttranscriptional\tprocessing)\tto\tform | [
-0.0019173950422555208,
-0.08323676884174347,
-0.025684459134936333,
-0.06767628341913223,
-0.04213176667690277,
0.03992607444524765,
0.07009588927030563,
0.047714222222566605,
0.0005510148475877941,
-0.0023073856718838215,
0.04016922041773796,
-0.03889128938317299,
0.002653747098520398,
0... |
mature\t\nmessenger\tRNA\t(mRNA)\n\tfrom\twhich\tthe\n\tintrons\thave\tbeen\tremoved\tand\tthe\tnucleotide\nsequence\tof\tthe\tmRNA\tis\tready\tto\tbe\ttranslated\tinto\tthe\tamino\tacid\tsequence\tof\tthe\tencoded\nprotein.\tThe\tprotein\tsynthesis\tprocess\tis\tcalled\t\ntranslation\n.\tEach\tset\tof\tthree\tnucleoti... | [
-0.028483957052230835,
-0.10969621688127518,
0.005660166032612324,
-0.06031623110175133,
-0.12755107879638672,
-0.002090816618874669,
0.015122069977223873,
0.01374231930822134,
-0.00993301160633564,
0.12398044019937515,
0.1217069998383522,
-0.04276993125677109,
-0.033801715821027756,
0.043... |
translation\n.\tEach\tset\tof\tthree\tnucleotides\tmakes\tup\na\t\ncodon\n,\twhich\tin\tturn\tspecifies\ta\tparticular\tamino\tacid\tand\tits\tposition\twithin\tthe\tprotein\t(\nFigs.\t6.3\nand\t\n6.4\n).\tFollowing\ttranslation,\tmost\tproteins\tneed\tfurther\n\tprocessing\t(\nposttranslational\nmodification\n)\tbefor... | [
-0.01200702041387558,
-0.0528547577559948,
0.04491226375102997,
-0.08087524771690369,
-0.09408652037382126,
0.007861766964197159,
0.032527074217796326,
0.033128149807453156,
0.003104701405391097,
0.09265489876270294,
0.13887478411197662,
-0.022748293355107307,
-0.013540852814912796,
0.0521... |
enzymatically\tprocessed\tbefore\tbecoming\tactive\tor\tother\tproteins\tthat\tare\tphosphorylated\tor\nglycosylated\tprior\tto\tbeing\tfunctional.\nFIG.\t6.3\nDNA\tGenetic\t\nCode\tDictates\tAmino\tAcid\tIdentity\tand\tOrder.\n\t\nAll\tliving\torganisms\tare\tcomposed\nlargely\tof\tproteins.\tProteins\tare\tlarge,\tco... | [
-0.07792062312364578,
-0.044383857399225235,
0.018081869930028915,
-0.06776876747608185,
-0.06985031813383102,
-0.006624246947467327,
0.0173973198980093,
0.020002545788884163,
-0.04835755005478859,
0.06841815263032913,
0.1646687239408493,
-0.015850266441702843,
-0.007524877320975065,
0.010... |
acids.\tTwenty\tdifferent\tkinds\tof\tamino\tacids\tare\tusually\tfound\tin\tproteins.\tWithin\tthe\tgene,\teach\tspecific\nsequence\tof\tthree\tdeoxyribonucleic\tacid\tbases\t(codons)\tdirects\tthe\tcells\tprotein-synthesizing\n\tmachinery\tto\nadd\tspecific\tamino\tacids.\tFor\texample,\tthe\tbase\tsequence\tATG\tcod... | [
0.0020839173812419176,
-0.07232054322957993,
0.018741318956017494,
-0.06608833372592926,
-0.10329212248325348,
0.024819038808345795,
0.03716687113046646,
0.033847518265247345,
0.024750715121626854,
0.061866503208875656,
0.10159874707460403,
-0.057208798825740814,
0.02641281671822071,
0.026... |
Because\tthree\tbases\tcode\tfor\tone\tamino\tacid,\tthe\tprotein\tcoded\tby\tan\taverage-sized\tgene\t(3000\tbp)\ncontains\t1000\tamino\tacids.\tThe\tgenetic\tcode\tis\tthus\ta\tseries\tof\tcodons\tthat\tspecify\twhich\tamino\tacids\tare\nrequired\tto\tmake\tup\tspecific\tproteins.\t\nA,\n\tadenine;\t\nbp,\n\tbase\tpa... | [
-0.02592649683356285,
-0.07119134068489075,
0.07026251405477524,
-0.0714305192232132,
-0.0803798958659172,
-0.005361239425837994,
0.0821385532617569,
0.08857091516256332,
0.03490503132343292,
0.090804822742939,
0.07524164021015167,
-0.04235187917947769,
0.028355775400996208,
0.035166256129... |
bp,\n\tbase\tpairs;\t\nC,\n\tcytosine;\t\nG,\n\tguanine;\t\nT,\nthymine.\n\tSource:\t\n(From\tU.S.\tDepartment\tof\tEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.)\nFIG.\t6.4\nDNA\t\nSequence\tVariation\tin\tGenes\tCan\tChange\tthe\tProtein\tProduced.\n\t\nHuman\tbeings\tdiffer\tfrom | [
-0.04280439764261246,
-0.053792327642440796,
0.030677830800414085,
-0.062488704919815063,
-0.04739309102296829,
0.08391391485929489,
0.09073005616664886,
0.059915781021118164,
-0.028734534978866577,
0.039481472223997116,
0.09645251929759979,
-0.05271480605006218,
-0.0006941948086023331,
0.... |
Human\tbeings\tdiffer\tfrom\neach\tother\tin\tonly\tan\testimated\t0.1%\tof\tthe\ttotal\tsequence\tof\tnucleotides\tthat\tcompose\tdeoxyribonucleic\nacid.\tThese\tvariations\tin\tgenetic\tinformation\tare\tthought\tto\tbe\tthe\tbasis\tfor\tthe\tphysical\tand\tfunctional\ndifferences\tbetween\tindividuals.\tSome\tvariat... | [
-0.004184775520116091,
-0.05879900977015495,
0.03592286258935928,
-0.04059584066271782,
-0.1012025848031044,
0.013197791762650013,
0.05908985063433647,
-0.003415468381717801,
-0.015849359333515167,
0.11942484974861145,
0.1431959569454193,
-0.11131145805120468,
-0.03643212467432022,
0.04177... |
no\teffect\ton\tthe\tprotein\nthat\tis\tproduced;\tothers\tcan\tlead\tto\tdisease\tor\tan\tincreased\tsusceptibility\tto\ta\tdisease.\n\tSource:\t\n(From\tU.S.\nDepartment\tof\tEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.)\nInvestigation\tof\tthese\tdownstream\tsteps\tin\tthe\tgene\texpression\tprocess\tha... | [
-0.04264495149254799,
-0.01690959930419922,
0.024479303508996964,
-0.06002148985862732,
-0.02675614133477211,
-0.0087056839838624,
0.0926283672451973,
-0.006704750936478376,
0.02479882910847664,
0.02280430682003498,
0.08335031569004059,
0.024724081158638,
0.08059000968933105,
-0.0086996415... |
often\tcalled\tthe\t“omics”\t(\nHasin\tet\tal,\t2017\n).\tThese\tdisciplines\tcorrelate\twith\tthe\tmajor\tsteps\tin\n\tthe\nprocess\tof\tgenetic\tinformation\tretrieval\tand\ttranslation:\ttranscriptomics,\tposttranscriptional\tand\nposttranslational\tprocessing,\tproteomics,\tmetabolomics,\tand\tepigenomics\t(see\t\n... | [
-0.0292651429772377,
-0.04590360447764397,
-0.011206874623894691,
-0.023623710498213768,
-0.05423852428793907,
-0.0002819766814354807,
0.042553387582302094,
0.039990298449993134,
0.04249614104628563,
0.04476822912693024,
0.06785231828689575,
-0.003550079185515642,
-0.006789369508624077,
0.... |
In\thigher\torganisms\tsuch\tas\thuman\tbeings,\tthe\texpression\tof\tthe\tinformation\tencoded\twithin\tthe\ngenes\tis\tregulated\tat\tthe\tchromosome\tlevel\tand\tat\tthe\tDNA\tlevel.\tIn\tboth\n\tcases\tthe\tstrategy\tis\tthe\nsame:\tphysically\tblock\tor\tallow\taccess\tto\tthe\tgenes\tin\torder\tto\tprevent\tor\ta... | [
0.009661834686994553,
-0.049170736223459244,
0.05344019830226898,
-0.038696419447660446,
-0.09255506098270416,
0.0022612623870372772,
0.05682014673948288,
-0.020471109077334404,
0.021245552226901054,
0.08497796207666397,
0.0849974974989891,
-0.021636582911014557,
0.05798143520951271,
0.007... |
genes.\tAs\tdescribed\tearlier,\tthe\tlarge\tamount\tof\tDNA\tin\tthe\tgenome\tis\tcondensed\tand\tnot\tavailable\nfor\ttranscription.\tThe\tregion\tof\tthe\tchromosome\tto\tbe\ttranscribed\tmust\tfirst\tbe\topened\t(relaxed)\nbefore\tRNA\tpolymerase\tcan\taccess\tthe\tpromoter\tof\tthe\tgene\tof\tinterest.\tThe\tattac... | [
-0.006488370709121227,
-0.06287892162799835,
0.04601108655333519,
0.008731076493859291,
-0.12322530895471573,
0.0031143424566835165,
0.06700152903795242,
-0.03381505236029625,
-0.016022879630327225,
0.10120542347431183,
0.11118724197149277,
-0.03639267385005951,
0.013061626814305782,
0.014... |
of\tacetyl\tor\nother\tchemical\tgroups\tto\tthe\thistone\tproteins\trelaxes\tthe\tchromosome\tand\tpermits\taccess\tto\tthe\nDNA.\tIn\tthe\tabsence\tof\tthe\tattachment\tof\tthese\tchemical\tgroups,\tthe\tchromosome\tstays\tcondensed,\nthe\tpromoter\tis\tnot\taccessible,\tand\tthe\tgene\tis\tnot\texpressed\t(\nFig.\t6... | [
-0.02455129288136959,
-0.02852453850209713,
0.060645222663879395,
-0.03552766516804695,
-0.1064620092511177,
-0.003050372004508972,
0.07826979458332062,
-0.0179046131670475,
0.02551419287919998,
0.0949220284819603,
0.11413875967264175,
-0.02507551573216915,
0.02673657424747944,
0.015936417... |
Fig.\t6.5\n).\nFIG.\t6.5\nEpigenetic\tregulation\tof\tgene\texpression\tthrough\thistone\tmodification\tand\tDNA\nmethylation.\n\tSource:\t\n(Image\tcredit:\tDarryl\tLeja,\tNational\tHuman\tGenome\tResearch\tInstitute,\tNIH.)\nA\tsimilar\tprocess\tis\tused\tat\tthe\tDNA\tlevel\tfor\tpromoting\tor\tinhibiting\ttranscrip... | [
-0.007129486184567213,
0.0028215262573212385,
0.06285171210765839,
-0.05580165982246399,
-0.07810819149017334,
-0.0037032505497336388,
0.06805486977100372,
-0.008588679134845734,
0.008129085414111614,
0.07386435568332672,
0.12097222357988358,
-0.06481567770242691,
0.013641628436744213,
0.0... |
chromosome\thas\trelaxed\texcept\tthat\tthe\tchemical\tgroup\tis\tfrequently\ta\tmethyl\tgroup.\tRecall\tthe\narchitecture\tof\ta\n\ttypical\tgene\tas\thaving\ta\tregulatory\tregion,\ta\tpromoter\tregion,\tand\ta\tcoding\tregion.\nWhen\tmethyl\tgroups\tare\tattached\tto\tthe\tDNA\tin\tthe\tpromoter\tregion,\tthe\tRNA\t... | [
0.0014156788820400834,
-0.028891945257782936,
-0.009394143708050251,
-0.03440289944410324,
-0.15339475870132446,
-0.004987029824405909,
0.04451938346028328,
0.010678383521735668,
0.025841305032372475,
0.07944821566343307,
0.12274181842803955,
-0.04341529682278633,
-0.03711966052651405,
0.0... |
physically\tblocked\tfrom\tattaching\tand\tinitiating\ttranscription.\tFor\ttranscription\tto\toccur\tin\thigher\norganisms,\tmethyl\tgroups\tmust\tbe\tremoved,\tand\tspecialized\tproteins\tcalled\ttranscription\tfactors\nmust\tbind\tto\tthe\tDNA\tin\tthe\tregulatory\n\tregion.\tTranscription\tfactors\thave\ta\tDNA\tbi... | [
0.03753224015235901,
-0.06842511147260666,
0.04380129277706146,
-0.028185255825519562,
-0.11894409358501434,
-0.025035886093974113,
0.07545842230319977,
0.002426634542644024,
0.01638856902718544,
0.07778215408325195,
0.09717581421136856,
-0.05159195885062218,
-0.003904103534296155,
0.05424... |
region.\tTranscription\tfactors\thave\ta\tDNA\tbinding\tsite\tand\ta\nligand\tbinding\tsite.\tThis\tlatter\tsite\tcan\tbind\ta\tsmall\tmolecular\tweight\t“sensor”\tmolecule\t(a\t\nligand\n)\nthat\tchanges\tthe\tconformation\tof\tthe\ttranscription\tfactor\tand\tchanges\tits\tability\tto\tbind\tto\tDNA.\tIn | [
0.04619026556611061,
-0.0362163782119751,
0.04649719223380089,
-0.06816886365413666,
-0.07172492891550064,
-0.022732995450496674,
0.09484577924013138,
-0.017888512462377548,
-0.0060936142690479755,
0.0741783082485199,
0.10015750676393509,
-0.05158914253115654,
0.013663453981280327,
0.06704... |
higher\torganisms\tbinding\tmay\tinvolve\tmultiple\ttranscription\tfactors,\teach\tbinding\tits\tspecific\tligand.\nDepending\ton\tthe\tgene,\tmultiple\n\ttranscription\tfactors\tmay\tconnect\twith\tDNA\tindividually\tor\tform\ta\ncomplex\tthat\tthen\tallows\tattachment\tto\tthe\tDNA.\tThe\texpression\tof\tsome\tgenes\... | [
0.007351391017436981,
-0.09042281657457352,
0.04813414067029953,
-0.014055553823709488,
-0.1227208822965622,
0.008671442978084087,
0.05605270341038704,
-0.026765212416648865,
0.006638986058533192,
0.07555367052555084,
0.110488161444664,
0.0024968248326331377,
0.037990737706422806,
0.038824... |
complex\tand\tfor\tothers\ttranscription\tis\tsilenced.\nFood\tplays\tkey\troles\tin\tthe\tregulation\tof\tgene\texpression.\tThe\tacetyl\tand\tmethyl\tgroups\toriginate\nfrom\tfood\tand\tmany\tof\tthe\tligands\tthat\tbind\tto\ttranscription\tfactors\tare\tderived\tfrom\n\tfood.\tFood\tis\nan\timportant\tsource\tof\tin... | [
0.0029270071536302567,
-0.030177859589457512,
0.029663341119885445,
-0.001759837381541729,
-0.05116071179509163,
-0.0029133998323231936,
0.08115588873624802,
-0.02224786765873432,
0.013168598525226116,
0.09002876281738281,
0.12079518288373947,
-0.08449725061655045,
0.031688492745161057,
0.... |
lower\torganisms\tthe\tinteraction\twith\tDNA\tis\tdirect.\tFood\tmolecules\tplaced\tinto\tthe\tgrowth\tmedium\nsurrounding\tthe\torganisms,\tsuch\tas\tbacteria,\tcan\tturn\ton\tor\toff\tgenes.\tThe\tclassic\texamples\tof\nregulation\tof\tgene\texpression\tin\tlower\torganisms\tby\tfood\tcan\tbe\tseen\twith\tthe\tsugar... | [
-0.0049569797702133656,
-0.03646964579820633,
0.03625603765249252,
-0.03525099530816078,
-0.06805815547704697,
0.010191603563725948,
0.02482583373785019,
-0.0026524935383349657,
-0.009524275548756123,
0.09435772895812988,
0.13129395246505737,
-0.019753800705075264,
0.0073905461467802525,
0... |
and\tthe\namino\tacid\thistidine.\tThe\tdisaccharide\tlactose\tis\tnot\ttypically\tin\tthe\tbacterium’s\tgrowth\tmedium.\nThe\tgenes\tcoding\tfor\tthe\tproteins\tneeded\tto\tmove\tlactose\tinto\tthe\tcell\tand\tto\tcleave\tthe\tsugar\tinto\nits\tglucose\tand\tgalactose\tcomponents\tare\tsilenced\tuntil\tlactose\tis\tde... | [
0.00952271930873394,
-0.06306750327348709,
0.032501690089702606,
-0.0006274320185184479,
-0.09437240660190582,
0.00960605964064598,
0.09566889703273773,
0.014052079059183598,
0.04453379288315773,
0.10265269130468369,
0.12169980257749557,
-0.0397089459002018,
0.01097051240503788,
0.04421203... |
of\tthe\tnutrient\thistidine\tin\tthe\tgrowth\tmedium\tsilences\tthe\tgenes\tneeded\tfor\tits\tbiosynthesis.\n\tSince\nhistidine\tis\tan\tessential\tamino\tacid,\tthese\tgenes\tare\tnormally\texpressed\tconstitutively\t(always\t“on”).\nIn\tthis\tway\tthe\torganism\tconserves\tits\tenergy\tby\tsensing\tthe\tenvironment,... | [
0.01715300790965557,
-0.05244813486933708,
0.040914203971624374,
-0.008556566201150417,
-0.04282241687178612,
0.018310949206352234,
0.09231434762477875,
0.013547721318900585,
-0.0023756169248372316,
0.07597992569208145,
0.12096918374300003,
-0.03953009471297264,
0.011431116610765457,
0.069... |
silencing\tbiosynthesis,\tand\tmaking\tuse\tof\tthe\thistidine\tin\tthe\tenvironment.\nIn\tboth\tthe\tlactose\tand\thistidine\texamples,\tthere\tis\tcommunication\tbetween\tthe\tenvironment\tand\nthe\tDNA\tto\tsilence\tor\n\tactivate\tgenes,\tas\tappropriate\tto\tthe\thealth\tof\tthe\torganism.\tThe\tprocess\tof | [
0.01860509067773819,
-0.029050901532173157,
0.043474797159433365,
-0.03854959458112717,
-0.05692361295223236,
0.029263131320476532,
0.09166550636291504,
-0.013389295898377895,
0.020765310153365135,
0.09195674955844879,
0.12193330377340317,
-0.044094666838645935,
0.005970178637653589,
0.037... |
sensing\tand\tresponding\tto\tthe\texternal\tand\tinternal\tenvironments\tdiffers\tin\tcomplexity\tamong | [
0.049992408603429794,
-0.02501230686903,
0.07386902719736099,
0.000018198326870333403,
0.00618103239685297,
-0.02710109017789364,
0.162713423371315,
-0.03392399847507477,
0.021364815533161163,
0.05508799105882645,
0.09478878974914551,
-0.12354721873998642,
0.014067545533180237,
0.054308392... |
organisms\tbut\tthe\tbasic\tmotif\tis\tthe\tsame.\tGenes\tthat\tencode\troutinely\tneeded\tproteins\tare\nconstitutively\texpressed\tand\tsilenced\tby\ta\tfeedback\tmechanism\twhen\tthe\tquantity\tof\tthe\tend\nproduct\tis\tsufficient.\tAs\tthe\tend\tproduct\tlevel\n\tfalls,\tgene\texpression\tresumes.\tGenes\twhose\tp... | [
0.020882975310087204,
-0.05321666970849037,
0.06978722661733627,
-0.014827800914645195,
-0.06300348043441772,
0.05040714889764786,
0.034836724400520325,
-0.0010747399646788836,
-0.020774224773049355,
0.1119304895401001,
0.10936204344034195,
-0.053428638726472855,
0.02940990775823593,
0.034... |
falls,\tgene\texpression\tresumes.\tGenes\twhose\tprotein\nproducts\tare\tnot\troutinely\tneeded\tare\tsilenced\tuntil\tneeded,\tat\twhich\tpoint\tgene\texpression\tis\nactivated\tuntil\tthe\tenvironmental\ttrigger\t(such\tas\tlactose)\tis\texhausted\tand\texpression\tis\tsilenced.\nHuman\tbeings\thave\tsimilar\tbut\tm... | [
-0.019388003274798393,
-0.01858581230044365,
0.08178845047950745,
-0.0015920274890959263,
-0.03798989951610565,
0.02535393461585045,
0.09472360461950302,
0.010333467274904251,
-0.01906679756939411,
0.037236299365758896,
0.06054086983203888,
-0.05560454726219177,
0.04375303536653519,
0.0147... |
these\taspects\tcan\tbe\tinherited.\tThe\tprocess\tin\thigher\n\torganisms\tis\tcalled\t\nsignal\ttransduction\n\tand\nthere\tare\tmore\tsteps\tand\tmore\tplayers\tinvolved\tin\tthe\tprocess.\tFood\tcontains\tnumerous\tbioactive\nmolecules\tfrom\tplants\tand\tanimals\tthat\tplay\timportant\troles\tin\tregulating\tgene\... | [
0.01611088030040264,
-0.08554327487945557,
0.046780358999967575,
-0.03148367628455162,
-0.07661006599664688,
0.029844263568520546,
0.13422265648841858,
0.03954014182090759,
-0.0061968532390892506,
0.0913928970694542,
0.10838993638753891,
-0.02261313609778881,
-0.009515595622360706,
0.01749... |
serving\tas\t“sensors”\tof\tthe\texternal\tenvironment.\tAmong\tthese\tbioactives\tare\tfamiliar\tcompounds\nsuch\tas\tisoflavones\tfrom\tsoybeans,\tcurcumin\tfrom\tthe\tspice\tturmeric,\n\tglucosinolates\tfrom\ncruciferous\tvegetables,\tand\tepigallocatechin-3-gallate\tfrom\tgreen\ttea.\tFor\tadditional\tinformation\t... | [
0.008288606069982052,
-0.06949521601200104,
0.02919568493962288,
-0.021488431841135025,
-0.10129240155220032,
-0.02166043408215046,
0.07525214552879333,
0.00948073249310255,
0.001569035230204463,
0.022635474801063538,
0.0977296233177185,
-0.06035590171813965,
0.00874384492635727,
-0.000388... |
food\tmolecules\tas\tsensors,\texamples\tof\tcommon\tbioactive\tfood\tmolecules,\tand\texamples\tof\tthe\nintricate\tsystem\tof\ttransducing\tthese\tenvironmental\tsignals\tto\tsilence\tor\tactivate\tgenes,\tsee\t\nBoxes\n6.3\n\tand\t\n6.4\n.\nBOX\t6.3\nHow\tFood\tand\tGenes\tCommunicate\nTranscription\tfactors\tare\n\... | [
-0.00758799072355032,
-0.042995624244213104,
0.010377852246165276,
0.007017148658633232,
-0.03348772972822189,
0.032677046954631805,
0.11490403115749359,
-0.013266637921333313,
-0.03539803996682167,
0.04889923706650734,
0.12484058737754822,
-0.05331810191273689,
0.01732148975133896,
-0.016... |
a\tsmall\tmolecular\tweight\tligand\tin\tanother\tregion.\tThe\tcomplex\tthen\tbinds\tto\tDNA\tand\tinfluences\ngene\texpression.\tIn\tthis\tway,\tfood-derived\tmolecules\t(often\treferred\tto\tas\t\nbioactive\tfood\ncomponents\n)\tand\tnonfood\tmolecules\tsuch\tas\ttoxic\tenvironmental\tchemicals\tcommunicate\twith\ng... | [
-0.020817305892705917,
-0.07029621303081512,
0.03230413794517517,
-0.008695009164512157,
-0.07594703882932663,
0.002871001837775111,
0.0867517739534378,
0.014277624897658825,
0.004966954700648785,
0.057514362037181854,
0.12317867577075958,
-0.05214162543416023,
0.02303391881287098,
0.04073... |
genes\tand\tinfluence\twhich\tones\tare\tswitched\ton\tor\n\toff,\tas\tneeded.\nThese\tligands\tmay\tregulate\ttranscription\tof\tgenes\tneeded\tfor\ttheir\tmetabolism.\tAlternatively,\nthey\tmay\tcommunicate\ta\tbroader\tmessage,\tsuch\tas\tthe\tpresence\tof\tchronic\tinflammation\tand\tthe\nneed\tto\tdampen\tthe\texp... | [
-0.036332424730062485,
-0.048016034066677094,
0.04549337178468704,
-0.025568613782525063,
-0.0836760625243187,
0.03437928110361099,
0.09503073245286942,
-0.0229189395904541,
-0.01647409237921238,
0.07750067859888077,
0.1157197579741478,
-0.05687004327774048,
0.03486505150794983,
0.00059717... |
bioactive\tfood\tcomponents\tinclude\tthe\tomega-3\tfatty\tacids\tinvolved\tin\tsilencing\ttranscription\tof\nproinflammatory\n\tgenes,\tderivatives\tof\tvitamin\tA\tand\tvitamin\tD,\tand\tnumerous\tplant-derived\tsmall\nmolecular\tweight\tligands\t(phytonutrients).\tSee\t\nBox\t6.4\n\tfor\tfurther\tdiscussion\tof\tphy... | [
-0.06465069949626923,
-0.10187698155641556,
-0.04164784401655197,
0.022387390956282616,
-0.014872962608933449,
0.06198908016085625,
0.06392479687929153,
0.05427408218383789,
-0.023046407848596573,
0.02317815087735653,
0.13261596858501434,
-0.046342648565769196,
-0.03400258347392082,
-0.001... |
Box\t6.4\n\tfor\tfurther\tdiscussion\tof\tphytonutrients.\nIn\thuman\tbeings\tthis\tprocess\tof\tsensing\tthe\tenvironment\tand\tcommunicating\twith\tDNA\tis\ta\nmore\tcomplex\tversion\tof\tthe\tability\tof\tlower\torganisms\tto\tsense\tnutrients\tin\tthe\tgrowth\tmedium\nand\tturn\ton\tor\toff\tthe\texpression\tof\n\t... | [
0.00018182398343924433,
-0.035248685628175735,
0.03689425438642502,
0.0026940726675093174,
-0.05467339977622032,
0.04570953547954559,
0.05338262766599655,
-0.02348729595541954,
-0.024166643619537354,
0.07496356219053268,
0.10861874371767044,
-0.018597576767206192,
0.018224334344267845,
0.0... |
genes\tneeded\tfor\tnutrient\tmetabolism.\tIn\thigher\torganisms\nthere\tare\tmore\tsteps\tand\tmore\tplayers\tinvolved\tin\tthe\tprocess\tbut\tthe\tbasic\ttheme\tis\tthe\tsame:\tto\nprotect\tthe\torganism\tby\tresponding\tappropriately\tto\tthe\tstate\tof\tthe\tever-changing\tenvironment. | [
-0.020506976172327995,
-0.03378702700138092,
0.043612636625766754,
-0.030268162488937378,
-0.04086203873157501,
0.052289966493844986,
0.060474757105112076,
0.0013896889286115766,
-0.0380554273724556,
0.10602391511201859,
0.11623802036046982,
-0.08540310710668564,
-0.004699288867413998,
-0.... |
If\tthe\tmolecule\tthat\ttriggers\tthe\tswitching\ton\t(or\toff)\tof\ta\tgene\tis\tfat-soluble\t(hydrophobic)\tand\tof\nsmall\tmolecular\tweight,\tit\ttypically\tcan\tpass\n\tthrough\tthe\tcellular\tand\tnuclear\tmembranes\tand\nbind\tto\tDNA\tthrough\tDNA-binding\ttranscription\tfactors.\tExamples\tinclude\tthe\tstero... | [
-0.036313366144895554,
-0.10874632745981216,
0.058573126792907715,
-0.055874597281217575,
-0.03731308504939079,
-0.008446531370282173,
0.08246200531721115,
0.0648515522480011,
-0.006540786940604448,
0.04935396835207939,
0.09443134814500809,
-0.061534300446510315,
-0.011088741943240166,
0.1... |
vitamin\tA,\tvitamin\tD,\tand\tthyroid\thormones.\tIf\tthe\tmolecule\tis\tlarge\tor\twater-soluble\n(hydrophilic),\tit\twill\tnot\treadily\tpass\tthrough\tmembranes.\tInstead\tit\twill\tdock\twith\treceptors\ton\nthe\touter\tcell\tmembrane.\tDocking\tsets\toff\tthe\tprocess\tof\t\nsignal\ttransduction\n,\ta\tmultistep | [
-0.02021533064544201,
-0.1268426477909088,
0.05979865416884422,
-0.043871402740478516,
-0.09886816143989563,
0.0027468064799904823,
0.09400781989097595,
0.051739662885665894,
-0.032889336347579956,
0.025255165994167328,
0.06384219974279404,
-0.036429356783628464,
-0.01814159005880356,
0.01... |
signal\ttransduction\n,\ta\tmultistep\ncascade\tthat\tamplifies\tthe\tinitial\tsignal\tand\tultimately\tresults\tin\tan\tactivator\tmolecule\tbinding\tto\na\ttranscription\tfactor\tthat\tin\tturn\tbinds\tto\tDNA\tand\tactivates\tor\tinhibits\texpression\tof\tthe\ttarget\ngene.\tNumerous\tfood-derived\tmolecules\tare\ti... | [
-0.006389911286532879,
-0.07177473604679108,
0.0417151153087616,
-0.03351954370737076,
-0.0781756341457367,
-0.0034177638590335846,
0.07829439640045166,
0.006888172589242458,
-0.005220450460910797,
0.05872327461838722,
0.1180676519870758,
-0.03077603131532669,
0.007156068459153175,
0.04414... |
The\tnuclear\tfactor-κB\t(NF-κB)\tfamily\tof\ttranscription\tfactors\tprovides\tan\texample\tof\tsuch\ta\nsignal\ttransduction\n\tmodel\tof\tgene\tregulation\tin\thigher\torganisms.\tThese\ttranscription\tfactors\nregulate\tnumerous\tgenes\tinvolved\twith\tinflammation,\timmunity,\tcell\tproliferation\tand | [
-0.0037359122652560472,
-0.07263720780611038,
0.0013493933947756886,
-0.004599251318722963,
-0.02266882173717022,
0.06606636196374893,
0.05676209181547165,
0.06789833307266235,
0.026523636654019356,
0.05252012982964516,
0.08520371466875076,
-0.06211034581065178,
-0.013637648895382881,
0.05... |
differentiation,\tand\tapoptosis\t(programmed\tcell\tdeath).\tThe\tNF-κB\tfactors\treside\tin\tthe\tcytoplasm\nand\tare\tkept\tinactive\tby\tthe\tbinding\tof\tinhibitors.\tWhen\ta\tsignal\tmolecule\tfrom\tthe\tenvironment\nconnects\tto\treceptors\ton\tthe\tcell\tsurface,\n\ta\tstepwise\tcascade\tis\tinitiated\tthat\tac... | [
-0.02663811296224594,
-0.07447972148656845,
0.004007051698863506,
-0.04733441397547722,
-0.0631823018193245,
0.00545094721019268,
0.06797243654727936,
0.08130106329917908,
0.02398187480866909,
0.09438017010688782,
0.06524191796779633,
-0.049829769879579544,
0.003656908171251416,
0.06604447... |
a\tstepwise\tcascade\tis\tinitiated\tthat\tactivates\tthe\tNF-κB\ntranscription\tfactors.\tThe\tactive\tfactors\tthen\ttranslocate\tto\tthe\tnucleus\tto\tbind\tto\tgenes\twhose\nexpression\tis\tunder\ttheir\tregulation.\nActivators\tof\tthis\tfamily\tof\ttranscription\tfactors\tare\tmolecules\tthat\tsound\tthe\talarm\t... | [
0.03255488723516464,
-0.11148005723953247,
0.01626177318394184,
-0.020787855610251427,
-0.08329053968191147,
0.04264418035745621,
0.04909121245145798,
0.0382612906396389,
0.022037627175450325,
0.09802813827991486,
0.09178643673658371,
-0.04196106269955635,
0.022142155095934868,
0.073956675... |
organism\tis\tunder\tattack,\tsuch\tas\ttissue\tnecrosis\tfactor\talpha\t(TNFα),\tinterleukin-1\t(IL-1),\tand\nreactive\toxygen\n\tspecies\t(free\tradicals).\tIn\tcontrast,\tseveral\tfood\tphytonutrients\thave\tbeen\tshown\nto\thelp\tmaintain\tthe\tinactive\tstate\tof\tNF-κB\tand\tprotect\tagainst\tinflammation.\tThese... | [
-0.04329349100589752,
-0.0649489238858223,
0.019243618473410606,
-0.02720549888908863,
-0.041938379406929016,
0.06893662363290787,
0.05321221798658371,
0.08498627692461014,
-0.004270548932254314,
0.09803758561611176,
0.10262169688940048,
-0.048222508281469345,
0.026793137192726135,
0.05102... |
have\tbeen\tfound\tin\tthe\tcruciferous\tvegetables\t(indole-3-carbinol,\t3,3′-diindolylmethane),\tin\nsoybeans\t(genistein\tand\tother\tisoflavones),\tand\tin\tcurcumin,\tfrom\tthe\tspice\tturmeric.\nBOX\t6.4\nBioactive\tFood\tComponents:\n\t\nPhytonutrients\nFood\tcontains\tmany\tthousands\tof\tbiologically\tactive\t... | [
-0.004889833740890026,
-0.07183235883712769,
-0.03492283821105957,
-0.006102079525589943,
-0.04712333902716637,
0.07337822020053864,
0.052497703582048416,
0.05576978623867035,
-0.014007083140313625,
0.0009925200138241053,
0.1250779628753662,
-0.08350261300802231,
-0.007803084794431925,
-0.... |
components”)\tthat\tare\tbeing\tinvestigated\tfor\ttheir\thealth\tbenefits.\tBioactives\tderived\tfrom\tplants\nare\tcalled\t“phytonutrients”\t(“phyto”\tin\tGreek\tmeaning\t“plants”).\tThe\toriginal\tterm\tfor\tthese\nbioactives\twas\t“phytochemicals”\tbut\twas\tchanged\tto\tphytonutrients\tbecause\texpressed\ndiscomfo... | [
-0.003482061205431819,
-0.03825454041361809,
-0.00543621089309454,
0.06134064868092537,
0.030695708468556404,
0.10675592720508575,
0.0696011632680893,
0.0299760140478611,
-0.00836322270333767,
0.008612599223852158,
0.15964064002037048,
-0.031788695603609085,
-0.0035254978574812412,
-0.0249... |
discomfort\n\twith\tthe\tterm\t“chemicals.”\tAlthough\tnot\ttechnically\tnutrients,\tphytonutrients\tare\nemerging\tas\timportant\tmetabolic\tcomponents.\nFrom\ta\tdietary\tstandpoint,\tthe\tmost\tcommonly\tstudied\tphytonutrients\thave\tbeen\tthose\tfrom\nfruits,\tvegetables,\tlegumes,\tcereal\tgrains,\tnuts,\tseeds,\... | [
0.005035076290369034,
-0.0907127633690834,
0.05760301277041435,
0.056307353079319,
-0.06748330593109131,
0.014882235787808895,
0.13071341812610626,
0.07949942350387573,
0.014088690280914307,
0.003183185588568449,
0.09131654351949692,
-0.04252547398209572,
0.055289991199970245,
0.0269143804... |
chocolate\t(\nUpadhyay\tand\tDixit,\t2015\n;\t\nAndreesu\tet\tal,\t2018\n).\tPhytonutrients\tregulate\n\tnumerous\ncellular\tand\tmolecular\tpathways,\tsuch\tas\tpreventing\tcell\tproliferation\tand\taggregation,\nprotecting\tagainst\tinflammation\tand\toxidative\tstress,\tpotentiating\tsignals\tfrom\tthe\tenvironment, | [
-0.0213784072548151,
-0.0668472945690155,
0.09615356475114822,
0.029594603925943375,
-0.059934817254543304,
0.04784400016069412,
0.12217012792825699,
-0.008625324815511703,
-0.026088999584317207,
0.049742441624403,
0.10507775843143463,
-0.0964224711060524,
-0.03778336942195892,
-0.01662506... |
and\tregulating\tgene\texpression\tin\tresponse\tto\tenvironmental\ttriggers.\tThe\tbenefits\tof\tthese\ncompounds\tare\tbeing\tinvestigated\tin\tmany\tprevalent\tchronic\tdisorders,\tsuch\tas\tcancer,\tvascular\ndisease\t(hypertension,\n\tdyslipidemia,\tsmooth\tmuscle\tproliferation\tleading\tto\tintimal\tthickening), | [
-0.008242242969572544,
-0.08143681287765503,
0.03795731067657471,
0.011073333211243153,
-0.067266084253788,
0.004766036290675402,
0.08495171368122101,
0.06508499383926392,
-0.009835628792643547,
0.05427619814872742,
0.0885591208934784,
-0.0689413771033287,
0.016290923580527306,
0.045242652... |
diabetes\t(glucose\tintolerance,\tinsulin\tresistance),\tand\tneurodegeneration.\nPolyphenols\tare\tthe\tlargest\tcategory\tof\tphytonutrients\tand\tinclude\tsimple\tphenolic\tacids,\nstilbenes,\tcurcuminoids,\tchalcones,\tlignans,\tflavonoids,\tand\tisoflavones.\tCommon\tfood\tsources\tof\npolyphenols\tinclude\tgenist... | [
-0.04048817977309227,
-0.017894139513373375,
-0.003738811705261469,
0.06935825943946838,
-0.021364625543355942,
0.044172365218400955,
0.07646460086107254,
0.05671250447630882,
0.01096961461007595,
0.008743385784327984,
0.0655522421002388,
-0.01061359141021967,
-0.0359848327934742,
-0.05843... |
polyphenols\tinclude\tgenistein\tand\tdaidzein\t(soy),\tresveratrol\n\t(purple\tgrape\tskins,\tred\twine),\nquercetin\t(onions),\tcatechins\tand\tepicatechins\t(beans,\tgreen\ttea,\tblack\ttea,\tapricots,\tchocolate),\nproanthocyanidins\t(apples,\tcocoa,\tberries),\tand\tcurcumin\t(turmeric,\tmustard,\tcurries).\tCurcu... | [
-0.07867511361837387,
-0.07033602893352509,
0.022572243586182594,
0.014278206042945385,
-0.027709713205695152,
0.08108469098806381,
0.08969514071941376,
-0.012082934379577637,
0.04452875256538391,
0.024453019723296165,
0.10798999667167664,
-0.031088482588529587,
-0.01522860862314701,
-0.04... |
is\talso\tantiinflammatory\tand,\tas\tsuch,\tis\tpotentially\thelpful\tin\tvirtually\tall\tof\tthe\tchronic\tdisorders\nsince\tlow-grade\tchronic\tinflammation\tis\tan\tunderlying\tmechanism.\tGlucosinolates\n\tare\tsulfur-rich\ncompounds\tthat\toccur\tin\tcruciferous\tvegetables,\tsuch\tas\tbroccoli,\tcauliflower,\tBr... | [
0.018749825656414032,
-0.06944283097982407,
0.0737147331237793,
-0.011665507219731808,
-0.11528836190700531,
0.005086654331535101,
0.08987174928188324,
0.005302581936120987,
-0.0057293265126645565,
0.07542591542005539,
0.03823303431272507,
-0.05515161156654358,
0.0026710431557148695,
0.050... |
and\tkale.\tMetabolism\tof\tglucosinolates\tyields\tisothiocyanates\t(e.g.,\tsulforaphane)\tand\tindoles\n(e.g.,\tindole-3-carbinol),\twhich\thave\tbeen\tfound\tto\thave\tanticarcinogenic\tproperties\t(\nLampe\tand\nPeterson,\t2002\n;\t\nPeterson\tet\tal,\t2002\n).\tThe\tcruciferous\tvegetables\tand\ttheir\tglucosinola... | [
0.04621725529432297,
-0.04572049528360367,
0.040091924369335175,
-0.006397014483809471,
-0.08152439445257187,
0.045081112533807755,
0.06756504625082016,
0.01366196759045124,
0.0018354206113144755,
0.08752087503671646,
0.09225134551525116,
-0.09842772036790848,
-0.02847178280353546,
0.04393... |
).\tThe\tcruciferous\tvegetables\tand\ttheir\tglucosinolate\ncomponents\n\talso\tplay\tan\timportant\trole\tin\tbiotransformation,\twhich\tis\ta\tkey\tmechanism\tfor\nprotecting\tthe\tbody\tagainst\tcancer.\nOf\tthe\tpolyphenols,\tisoflavones,\tcurcumin,\tglucosinolates,\tresveratrol,\tand\tepigallocatechin-3- | [
0.0011330709094181657,
-0.06826258450746536,
0.023338595405220985,
-0.02985428273677826,
-0.06427965313196182,
-0.003500120947137475,
0.08433997631072998,
0.02565212920308113,
0.03269025683403015,
0.04911848530173302,
0.08190687000751495,
-0.030067920684814453,
-0.004049141425639391,
0.045... |
gallate\t(EGCG)\tfrom\tgreen\ttea\thave\tbeen\tof\tparticular\tinterest\tbecause\tthey\tare\tknown\tto\ninfluence\tgene\texpression\tthrough\tepigenetic\tmechanisms\t(\nVanden\tBerghe,\t2012\n).\tIsoflavones,\ncurcumin,\n\tand\tEGCG\tare\timportant\tinhibitors\tof\tthe\tproinflammatory\tNF-κB\tsignaling\tcascade. | [
-0.02721792459487915,
-0.13450990617275238,
0.0072640725411474705,
-0.002290033269673586,
-0.0780126303434372,
0.00790770910680294,
0.03820551186800003,
0.09037309885025024,
0.020606424659490585,
0.030287934467196465,
0.07644540816545486,
-0.01577248051762581,
-0.025995584204792976,
0.0618... |
Resveratrol\tand\tcurcumin\tare\texamples\tof\tpolyphenols\tthat\tcan\tactivate\tSIRT1,\ta\thistone\ndeacetylase\tinvolved\tin\tinflammatory\tpathways,\tincluding\tNF-κB.\tThere\tare\tnumerous\tcell\nsignaling\tmechanisms\tinvolved\tin\tepigenetic\tregulation\tof\tgene\texpression;\tNF-κB\tis\tan\timportant\nexample\tb... | [
-0.024957366287708282,
-0.07517969608306885,
-0.010855637490749359,
0.00893821194767952,
-0.004804744850844145,
0.02977144345641136,
0.06887800991535187,
0.06590031832456589,
0.024096040055155754,
0.011370072141289711,
0.07082147896289825,
-0.010098996572196484,
0.011109940707683563,
0.022... |
example\tbecause\tit\tregulates\tseveral\tproinflammatory\n\tprocesses\tthat\tcontribute\tto\tchronic\ninflammation\tthat\tunderlies\tchronic\tdisorders.\tScientific\tresearch\tcontinues\tto\tsupport\tthe\nrecommendation\tfor\ta\tmostly\tplant-based\tdiet\tthat\tincludes\ta\twide\tvariety\tof\tfoods\tas\tessential\tto | [
0.028795424848794937,
-0.08963024616241455,
0.03188742697238922,
-0.044348329305648804,
-0.1017032191157341,
-0.009308995679020882,
0.03726613149046898,
0.020345525816082954,
0.007856275886297226,
0.07222889363765717,
0.09720275551080704,
-0.046818118542432785,
0.04697638377547264,
0.03045... |
long-term\thealth.\tSeveral\toverviews\tof\tphytonutrients,\ttheir\thealth\tbenefits,\tand\ttheir\nmechanisms\tcan\tbe\tfound\tin\t\nRescigno\tet\tal,\t2018\n;\t\nLee\tet\tal,\t2018\n;\t\nRescigno\tet\tal,\t2017\n;\t\nUpadhyay\nand\tDixit,\t2015\n;\tand\t\nGupta\tand\tPrakash,\t2014\n.\nIn\taddition\tto\tthese\tmechani... | [
-0.010253719054162502,
-0.03236737102270126,
0.06228726729750633,
-0.030442139133810997,
-0.06198771297931671,
0.022703928872942924,
0.0243400689214468,
-0.04937971755862236,
-0.0024705003015697002,
0.06888914108276367,
0.13334693014621735,
-0.03544905409216881,
0.022651873528957367,
0.003... |
These\tRNAs\tare\tproduced\tduring\ttranscription\tbut\tare\tnot\tmRNA\tand\ttherefore\tdo\tnot\tdirect\tprotein\nsynthesis.\tThere\tare\tlong\tnoncoding\tRNAs\t(lncRNA)\tand\tshort\tnoncoding\tRNAs\t(sncRNA),\twhich\ninclude\tmicroRNAs\t(miRNA)\tand\tsmall\tnucleotide\tRNAs\n\t(snRNA).\tThe\tfinding\tthat\tthese\tRNAs... | [
-0.03269999846816063,
-0.07113017141819,
0.0054059140384197235,
-0.06412110477685928,
-0.05554373562335968,
0.03782172501087189,
-0.023378124460577965,
0.027807580307126045,
-0.009315443225204945,
0.10631707310676575,
0.0784538984298706,
-0.01229953020811081,
-0.04474399611353874,
0.032112... |
(snRNA).\tThe\tfinding\tthat\tthese\tRNAs\tare\nnot\tsimply\textra\tnucleotides\tthat\twere\tremoved\tduring\tmaturation\tof\tpre-mRNA\tinto\tmRNA\tis\tfairly\nrecent.\tThe\troles\tof\tthese\tvarious\tRNAs\tare\tbeing\tinvestigated\tand\tinclude\tgene\tsilencing\tas\ta\tmajor\ntarget\t(\nMattick,\t2018\n).\tSeveral\tth... | [
-0.028800569474697113,
-0.08427894860506058,
0.01402341853827238,
-0.04940233752131462,
-0.07547719776630402,
0.04386157542467117,
0.004279776010662317,
0.007226869463920593,
-0.02942725084722042,
0.08311882615089417,
0.10486197471618652,
-0.024602316319942474,
-0.023190584033727646,
0.008... |
have\tbeen\treported.\tBoth\tlong\tand\tshort\tRNAs\thave\tbeen\tlinked\n\tto\tvarious\tmetabolic\tdisorders:\ndiabetes,\tobesity,\tcardiovascular\tdisease,\tcardiometabolic\tsyndrome,\tneurologic\tdisorders,\nnonalcoholic\tfatty\tliver\tdisease,\tand\tvarious\tcancers.\nEpigenomics\tand\tgene\texpression | [
-0.000770270184148103,
-0.056958600878715515,
0.013041066005825996,
0.011200498789548874,
-0.058779582381248474,
0.011439412832260132,
0.0824669823050499,
0.05015169084072113,
-0.06719329953193665,
0.0067695025354623795,
0.04298281669616699,
-0.029171360656619072,
-0.06960368901491165,
0.0... |
Epigenomics\tand\tgene\texpression\nThe\tregulation\tof\tgene\texpression\toccurs\tat\ttwo\tlevels:\tgenomic\tand\tepigenomic.\t“Epi”\tin\tGreek\nmeans\t“above,”\tas\tin\t“above”\tthe\tgenetic\tcode.\tGenomic\tcontrol\ttakes\tplace\twithin\tthe\tregulatory\nregion\tof\tgenes,\tupstream\tfrom\tthe\tpromoters.\t\nEpigene... | [
-0.028900250792503357,
-0.020354291424155235,
0.0009117028093896806,
-0.05728580430150032,
-0.04133446142077446,
0.009531720541417599,
0.037418022751808167,
0.002888788003474474,
-0.030059484764933586,
0.058923061937093735,
0.11336112022399902,
-0.060165274888277054,
-0.0042276098392903805,
... |
Epigenetics\n\tand\t\nepigenomics\n\trelate\tto\tprocesses\nthat\talter\tgene\texpression\tthrough\tmodification\tof\thistone\tproteins\tor\tDNA\twithout\tchanging\tthe\nsequence\tof\tthe\tDNA,\tthereby\tkeeping\tthe\tinformation\tin\tDNA\tintact.\tThis\tpoint\tis\timportant\tsince\nDNA\tencodes\tthe\tinformation\tfor\... | [
-0.0504947267472744,
-0.041347064077854156,
0.0044825137592852116,
-0.06729180365800858,
-0.08848676830530167,
0.015732184052467346,
0.03027971088886261,
-0.022927885875105858,
-0.04899038374423981,
0.09680746495723724,
0.15406519174575806,
-0.05323224142193794,
0.0030165938660502434,
0.02... |
this\tinformation\n\tinto\tan\toperating\tsystem\tthat\tgenerates\thuman\tfunction.\t\nEpigenetics\n\tis\tconcerned\nwith\tthe\tprocesses\tinvolved\tin\tregulating\tgene\texpression,\thow\tgenes\tare\tturned\ton\tor\toff\tand\tthe\nmechanisms\tinvolved.\tThese\tprocesses\tare\tparticularly\tcritical\tduring\tthe\tvario... | [
-0.006190895102918148,
-0.03452502563595772,
0.05789855867624283,
-0.03377443924546242,
-0.08663149923086166,
-0.003310814267024398,
0.04613381624221802,
0.026414383202791214,
-0.013427652418613434,
0.09303369373083115,
0.10364484041929245,
-0.053413085639476776,
0.00041643597069196403,
0.... |
human\tgrowth\tand\tdevelopment.\t\nEpigenomics\n,\tin\tcontrast,\tis\tthe\tcollective\tset\tof\tepigenetic\ttags\tin\na\tgenome.\tAlthough\n\tthe\tDNA\tsequence\tis\tthe\tsame\tfrom\tcell\tto\tcell,\tthe\tpattern\tof\tgene\texpression\nis\tdifferent\tamong\tdifferent\tcell\ttypes\tand\tthese\tpatterns\tcan\tbe\tinheri... | [
-0.009963960386812687,
-0.04507729783654213,
0.03405727818608284,
-0.02934042178094387,
-0.07236435264348984,
-0.0029897966887801886,
0.09476952254772186,
-0.011076243594288826,
-0.01588643155992031,
0.08931397646665573,
0.1254083663225174,
-0.06706231087446213,
0.009227065369486809,
0.038... |
epigenetic\tmarks\n\t(or\t“tags”)\tthat\tare\tcharacteristic\tof\teach\tcell\ttype\tdetermines\tthe\tgene\nexpression\tpattern\t(i.e.,\twhich\tgenes\tare\tactive\tor\tsilent\tat\tany\tgiven\tpoint).\tEpigenetic\tmarks\nrepresent\tan\tadditional\tset\tof\tinstructions\n\tbeyond\tthe\tDNA\t\ngenetic\tcode\n\tthat\tgovern... | [
0.010729046538472176,
-0.03755059838294983,
0.014357336796820164,
-0.04491725191473961,
-0.07737821340560913,
-0.003659577574580908,
0.06518338620662689,
-0.017259441316127777,
-0.0005272338748909533,
0.0843910500407219,
0.1205562874674797,
-0.09031488746404648,
0.02422306127846241,
0.0292... |
beyond\tthe\tDNA\t\ngenetic\tcode\n\tthat\tgoverns\tthe\tprocess\nof\tdecoding\tDNA\tinto\tRNA\tand\tprotein.\tEpigenomic\tresearch\tfocuses\ton\tunderstanding\twhich\nepigenetic\tmarks\tare\twithin\ta\tgenome,\thow\tchanges\tarise,\tthe\tinfluence\tof\tepigenetic\tpatterns\ton\nphysiologic\tfunction,\tand\thow\tthe\tm... | [
0.014421742409467697,
-0.013878920115530491,
0.07809924334287643,
-0.03625227510929108,
-0.07728654146194458,
0.0014315327862277627,
0.0640752911567688,
-0.02156238444149494,
0.009704271331429482,
0.09302560240030289,
0.08281350135803223,
-0.08021654933691025,
0.007807370740920305,
0.01176... |
physiologic\tfunction,\tand\thow\tthe\tmarks\tare\tinherited.\nEpigenetic\tgene\tregulation\tis\tachieved\tthrough\tthe\taddition\tor\tdeletion\tof\tchemical\tgroups\tto\nhistone\n\tproteins\tor\tmethyl\tgroups\tto\tDNA.\tTo\tdate,\tthe\tmore\tcommon\ttags\tare\tacetyl\tgroups\tadded\nto\thistone\tproteins\tand\tmethyl... | [
0.008126677945256233,
-0.08229086548089981,
0.0321342833340168,
-0.025824520736932755,
-0.07293670624494553,
0.008838949725031853,
0.06979186087846756,
0.03576447814702988,
0.019902164116501808,
0.06933394074440002,
0.11140178889036179,
-0.05282161384820938,
0.01957315020263195,
0.03951557... |
(attachment\tof\tSUMO\tgroups—small\tubiquitin-like\tmodifiers)\tare\talso\tused.\tDuring\tdevelopment\tof\nthe\tfertilized\tembryo\tmost\tof\tthe\tepigenetic\tmarks\tare\terased\t(genomic\treprogramming)\tbut\tsome\nremain\tand\tare\tpassed\n\tfrom\tparent\tto\tchild.\tIn\tthis\tway\tthe\tchild\tinherits\tsome\tof\tth... | [
0.0034345504827797413,
-0.019869288429617882,
0.03398868441581726,
-0.018742363899946213,
-0.04639362916350365,
-0.02714516781270504,
0.06776725500822067,
0.02699611335992813,
-0.0034472234547138214,
0.06206991896033287,
0.12412802129983902,
-0.01779206655919552,
0.026530331000685692,
0.04... |
experiences\tthat\tled\tto\tthe\tepigenetic\tpatterns\tin\tthe\tegg\tand\tsperm.\tResearch\tand\tadvances\tin\ntechnology\twill\tlikely\texpand\tthe\tlibrary\tof\tpotential\tepigenetic\ttags\tas\twell\tas\tour\tunderstanding\tof\nepigenetic\tinheritance.\nIdentical\t(monozygotic)\ttwins\tare\ta\tnatural\texample\tof\tt... | [
0.03873182833194733,
-0.017396939918398857,
0.08313068747520447,
0.008527220226824284,
-0.10803519189357758,
-0.019033396616578102,
0.07076578587293625,
-0.024936018511652946,
-0.00019434398564044386,
0.055409807711839676,
0.092057004570961,
-0.10180024057626724,
0.0019266335293650627,
0.0... |
beings.\n\tThe\ttwins\tare\tnot\tidentical\tphenotypically\tdespite\thaving\tidentical\tgenotypes.\tEpigenetic\nregulation\tof\tgene\texpression\tcontributes\tto\tthis\tphenomenon,\twhich\tis\tcalled\tmonozygotic\ndiscordance\t(also\tepigenetic\tdrift).\tSee\t\nBox\t6.5\n\tfor\ta\tfurther\texploration\tof\tthe\trole\to... | [
-0.0019068702822551131,
-0.02736208215355873,
0.07715395092964172,
0.028961868956685066,
-0.08487388491630554,
0.014106142334640026,
0.040103014558553696,
-0.06016441062092781,
0.0032164163421839476,
0.10652348399162292,
0.09499476104974747,
-0.13539399206638336,
-0.010922062210738659,
-0.... |
the\tdifferences\tin\tanthropomorphic\tfeatures\tand\tdisease\tsusceptibility\tas\tmonozygotic\ttwins\tage.\nBOX\t6.5\nEpigenetics\n\t\nand\tIdentical\tTwins\nHave\tyou\tever\twondered\twhy\tmost\tidentical\ttwins\tand\tother\tmonozygotic\tmultiples\thave\nincreasingly\tobvious\tphenotypic\tdifferences\tas\tthey\tage\t... | [
0.036472368985414505,
-0.0501030869781971,
0.04389171302318573,
0.004379060585051775,
-0.10922122746706009,
0.005484460853040218,
0.047944869846105576,
-0.06645059585571289,
0.0143921859562397,
0.08873794227838516,
0.09375014901161194,
-0.09973319619894028,
-0.0343390591442585,
0.040223039... |
Commonly\tencountered\tdifferences\tinclude\tphysical\tfeatures,\tdisease\tsusceptibility,\tand\npersonality.\tTwins\treared\tapart\ttend\tto\texhibit\tgreater\tobservable\tdifferences.\tHowever,\tnot\tall\nmonozygotic\ttwins\n\texhibit\tthis\tpattern.\tThe\tbasis\tfor\tthese\tdifferences\tlies,\tat\tleast\tin\tpart,\t... | [
0.061322491616010666,
-0.07065238803625107,
0.04475314915180206,
-0.008898850530385971,
-0.09161724895238876,
-0.011039523407816887,
0.054074034094810486,
-0.023886388167738914,
-0.02029707096517086,
0.033780332654714584,
0.07729505747556686,
-0.07403004169464111,
0.06162448599934578,
0.03... |
different\tepigenetic\tsignatures,\twhich\tleads\tto\tdifferential\tregulation\tof\tgene\texpression\tand\tthe\nphenomenon\tof\t“monozygotic\tdiscordance,”\talso\tcalled\t“epigenetic\tdrift.”\tEarly\tinvestigations\tby\nFraga\tand\tcolleagues\t(\nFraga\tet\tal,\t2005\n;\t\nPoulsen\tet\tal,\t2007\n)\tfound\tthat\tmonozy... | [
-0.024118702858686447,
-0.03400134667754173,
0.05506657063961029,
-0.041777655482292175,
-0.11207259446382523,
0.004778984468430281,
0.06265199184417725,
-0.02805616334080696,
-0.053741730749607086,
0.07649234682321548,
0.12480446696281433,
-0.09578225016593933,
-0.01332376804202795,
0.008... |
)\tfound\tthat\tmonozygotic\t(MZ)\ttwins\nwere\tidentical\tin\ttheir\n\tepigenetic\tpatterns\tearly\tin\tlife\tbut\tthat\tthe\tepigenetic\tpatterns\tof\tDNA\nmethylation\tand\thistone\tacetylation\tin\tolder\tMZ\ttwins\twas\tconsiderably\tdifferent.\tThese\tstudies\nwere\tsignificant\tin\texplaining\thow\tdifferent\tph... | [
0.010993041098117828,
-0.011181667447090149,
0.0905143991112709,
0.002219815505668521,
-0.0975739136338234,
0.009582814760506153,
0.08587468415498734,
-0.044936735183000565,
-0.05006694048643112,
0.06978949159383774,
0.10924642533063889,
-0.10900391638278961,
0.009926823899149895,
-0.00521... |
genotypes.\nRecently\tthe\tsituation\thas\tgrown\teven\tmore\tcomplex.\tWaterland\tand\tcolleagues\tdiscovered\tthat\nthe\ttiming\tof\tthe\trestoration\n\tof\tthe\tepigenetic\tmarks\tin\tmonozygotic\ttwins\tdetermines\thow\tsimilar\nthe\tmarks\tare\tbetween\tthe\ttwins\t(\nVan\tBaak\tet\tal,\t2018\n).\tThese\tmarks\tar... | [
0.02288636937737465,
-0.01609867624938488,
0.06477443128824234,
-0.05984196811914444,
-0.03398314118385315,
0.011593245901167393,
0.024981210008263588,
-0.048378344625234604,
-0.05769810080528259,
0.07449321448802948,
0.09758306294679642,
-0.09273727983236313,
0.0041227200999855995,
0.0104... |
Van\tBaak\tet\tal,\t2018\n).\tThese\tmarks\tare\terased\tduring\nfertilization\tand\trestored\tduring\tvery\tearly\tembryonic\tdevelopment.\tMonozygotic\tsiblings\tform\nwhen\tthe\tvery\tearly\tembryo\tsplits\tin\ttwo\tand\teach\tembryo\tdevelops\tinto\ta\tseparate\tindividual.\tIf\nthe\tepigenetic\tmarks\tare\treset\t... | [
0.04649093374609947,
-0.021461831405758858,
0.09057663381099701,
-0.036942530423402786,
-0.08984587341547012,
0.002769127022475004,
0.08141186833381653,
-0.018677450716495514,
-0.021476104855537415,
0.08378510177135468,
0.08954917639493942,
-0.05062076821923256,
0.029160354286432266,
0.028... |
the\tepigenetic\tpattern\twill\tbe\tthe\tsame\nfor\tboth\ttwins,\tcalled\t“epigenetic\tsupersimilarity”.\tIf\tthe\tmarks\tare\treset\tafter\tthe\tembryo\tsplits,\nthere\twill\tbe\tdifferences\tin\tepigenetic\tpatterns\tbetween\tthe\ttwins.\tIn\tboth\tcases\tthe\tDNA\nsequence\tis\tidentical,\tbut\tthe\tepigenetic\tpatt... | [
0.0029494899790734053,
-0.03503086790442467,
0.02487489953637123,
-0.06303349882364273,
-0.1407553255558014,
0.015401878394186497,
0.025255892425775528,
-0.00020283683261368424,
-0.00963824987411499,
0.07407432049512863,
0.1295677125453949,
-0.0721292644739151,
0.015529272146522999,
0.0157... |
of\tresetting\tthe\tepigenetic\tmarks.\nTwo\tfindings\tfrom\tthis\tstudy\n\tare\tintriguing\tand\tunder\tfurther\tstudy.\tOne\tis\tthe\tlink\tbetween\tthe\ngenes\tinvolved\tin\tepigenetic\tsupersimilarity\tand\tthe\tdevelopment\tof\tcancer.\tThe\tother\tis\ta\nrethinking\tof\tthe\tuse\tof\tmonozygotic\ttwins\tas\ta\tmo... | [
0.028286917135119438,
-0.04279747232794762,
0.06920681893825531,
-0.04543804004788399,
-0.07124342024326324,
-0.007820876315236092,
0.07211653888225555,
-0.026421131566166878,
-0.010592976585030556,
0.0911058858036995,
0.08555195480585098,
-0.02838827483355999,
0.054301667958498,
0.0234992... |
contributed\tby\tgenes\tvs.\tenvironment.\tThe\tlack\tof\tstratification\tof\tthe\ttwins\tin\tsuch\tstudies\tbased\non\ttheir\tepigenetic\tpattern\tat\tbirth\tmay\thave\n\tled\tto\tan\toverestimation\tof\tgenetic\tcontribution\tto\ndisease.\nEpigenetic\tmarks\tprovide\tthe\tinstructions\tfor\tthe\tdevelopment\tand\tdif... | [
0.03558286651968956,
-0.009892833419144154,
0.04988531768321991,
-0.02041093446314335,
-0.000924372929148376,
0.022422071546316147,
0.06862368434667587,
-0.02360554225742817,
-0.018525976687669754,
0.0743379220366478,
0.09637347608804703,
-0.04757814109325409,
0.053157951682806015,
0.01334... |
and\tfor\tdirecting\ttheir\taggregation\tinto\ttissues\tand\torgans.\tWith\tthe\texception\tof\tred\tblood\tcells,\nwhich\thave\tno\tnucleus,\teach\tof\tthe\tcells\tin\thigher\torganisms\tcontains\tthe\tfull\tset\tof\tDNA\tin\tthe\nnucleus.\tDuring\tdevelopment,\tthese\n\tcells\tdifferentiate\tinto\tthe\tvarious\ttypes... | [
0.03773445636034012,
-0.05708243325352669,
0.02549094147980213,
-0.057041700929403305,
-0.10357028990983963,
-0.019398149102926254,
0.0699891671538353,
-0.02326558716595173,
-0.021376190707087517,
0.09965178370475769,
0.11368560791015625,
-0.0006698461365886033,
0.08168462663888931,
0.0397... |
cells\tdifferentiate\tinto\tthe\tvarious\ttypes\tof\tcells\tneeded\tto\noperate\tthe\torganism,\tsuch\tas\teye\tcells,\tbone\tcells,\tliver\tcells,\theart\tcells,\tand\tso\ton.\tEach\tcell\ttype\nis\tspecialized\tfor\tparticular\ttasks,\twhich\trequires\tthat\tcertain\tof\tits\tgenes\tbe\ttranscribed\tand\tothers | [
0.011501098051667213,
-0.03369246795773506,
0.01788569800555706,
-0.0687522441148758,
-0.14216582477092743,
0.01250971108675003,
0.06726440042257309,
-0.012609473429620266,
0.018602825701236725,
0.09520059823989868,
0.10466697812080383,
-0.046338021755218506,
0.0491020642220974,
0.03474518... |
be\tsilenced.\tThe\timportance\tof\tnutrition\tduring\tthe\tprenatal\tand\tpostnatal\tdevelopmental\tperiods\ncannot\tbe\toveremphasized\tbecause\n\tthe\tdiet\tis\tthe\tsource\tnot\tonly\tof\tthe\tnutrients\tneeded\tfor\tgrowth\nbut\tfor\tthe\tepigenetic\tmarks\tthat\tdirect\tgrowth,\tdevelopment,\tand\tdifferentiation... | [
0.06422130018472672,
-0.013637821190059185,
0.058885425329208374,
-0.03877090662717819,
-0.03989943861961365,
0.03252028673887253,
0.07704945653676987,
0.007083212025463581,
-0.032140862196683884,
0.10435646027326584,
0.15618416666984558,
-0.03179033100605011,
0.020322643220424652,
0.02013... |
that\tmany\tother\tstressors\tin\taddition\tto\tfood\tinsufficiency\thave\tan\tepigenetic\teffect,\tsuch\tas\tpoverty,\nstress,\tand\ttoxic\texposure.\tA\tnew\tdiscipline,\tsocial\tepigenomics,\thas\tarisen\tthat\tfocuses\ton\tsocial\nexperiences\tthroughout\tthe\n\tlifespan\tand\tinvestigation\tof\tthe\tkey\tenvironme... | [
-0.0020532223861664534,
-0.04418574273586273,
0.029439833015203476,
-0.006832847837358713,
-0.055768925696611404,
-0.004191240295767784,
0.07437950372695923,
0.002383394166827202,
-0.03265726938843727,
0.04302600398659706,
0.09680457413196564,
-0.03895168378949165,
0.0051134550012648106,
0... |
epigenetic\teffects.\tSee\t\nBox\t6.6\n\tfor\tadditional\tinformation.\nBOX\t6.6\nSocial\tEpigenomics\nSocial\tepigenomics\tis\tconcerned\twith\tthe\tnegative\tand\tpositive\tinfluences\tof\tsocial\texperiences\nthroughout\tthe\tlifespan.\tThese\texperiences\tdo\tnot\talter\tthe\tDNA\tsequence,\tonly\tthe\tepigenetic\n... | [
-0.013502806425094604,
-0.05696791410446167,
-0.025466907769441605,
-0.025975363329052925,
-0.07361295074224472,
0.028962615877389908,
0.03989756107330322,
0.000016735501048970036,
-0.022325988858938217,
0.0860522910952568,
0.11062917858362198,
-0.05778421834111214,
-0.04250168427824974,
0... |
marks\tattached\tto\tthe\tDNA\tand\thistone\tproteins.\n\tThe\tepigenetic\tpattern\t(epigenome),\tin\tturn,\nalters\tgene\texpression.\tThis\tfeature\tis\timportant\tbecause\tgenes\tthat\tmight\tnormally\tprotect\nagainst\ta\tdisease\t(such\tas\tcancer\ttumor-suppressor\tgenes)\tmay\tbe\tturned\toff\tand\tgenes\tthat\n... | [
0.023332981392741203,
0.00546465627849102,
0.0664823055267334,
-0.011674823239445686,
-0.08556513488292694,
0.06335927546024323,
0.06939683854579926,
0.007498870138078928,
-0.031850796192884445,
0.03323599696159363,
0.11136192828416824,
-0.060471124947071075,
0.059255022555589676,
-0.00947... |
promote\tdisease\t(such\tas\tcancer\toncogenes)\tmay\tbe\tturned\ton.\nThe\tfocus\tof\tresearch\tin\tthis\tarea\tis\tto\tinvestigate\tthe\tkey\tenvironmental\tdrivers\tfor\taltering\tthe\nepigenetic\n\tpattern\tand\ttheir\tinfluences\ton\tfunction.\tNumerous\tfactors\tare\tbeing\tfound\tto\tcause\nchanges\tin\tthe\tepi... | [
-0.00425383448600769,
-0.0504770502448082,
0.06642398983240128,
-0.04393213987350464,
-0.06449751555919647,
0.03987599164247513,
0.09639588743448257,
-0.03182900324463844,
-0.01291136909276247,
0.05309708043932915,
0.12126094102859497,
-0.08625446259975433,
0.0782172903418541,
-0.005948200... |
encouraging\taspect\tof\tthis\twork\tis\tthat\tthese\tinfluencers\ton\tepigenetic\tpatterns\tare\tpotentially\nmodifiable.\tResearch\tis\tidentifying\twhat\tthe\tenvironmental\ttriggers\tare\tand\tthe\tmechanisms\tby\nwhich\tthey\tinfluence\tgene\texpression.\nSince\t2008\tthe\tNational\tInstitutes\ton\tMinority\tHealt... | [
-0.015360148623585701,
-0.0025585663970559835,
0.07098595798015594,
0.01044169906526804,
-0.04063646122813225,
0.025769053027033806,
0.07266993075609207,
-0.028824059292674065,
-0.040989018976688385,
0.040860097855329514,
0.0851285308599472,
-0.053022950887680054,
0.03046371601521969,
0.02... |
program\tfor\tfunding\tresearch\thighlighting\tsocial\tepigenomics,\tparticularly\tas\tit\tincludes\tthe\nhealth\tof\tminorities\tand\thealth\tdisparities\tin\tthe\tU.S.\tpopulation,\tespecially\tas\ta\tresult\tof\tracism\nand\tdiscrimination.\tThe\texpectation\tis\tthat,\tby\tidentifying\tepigenetic\tmodifications,\ti... | [
-0.0014716422883793712,
-0.03434125334024429,
-0.004632099997252226,
-0.044617872685194016,
-0.08362779766321182,
-0.03869226574897766,
0.06319866329431534,
-0.004448712803423405,
-0.028463764116168022,
0.05859721079468727,
0.05953259766101837,
-0.02342105656862259,
0.03962423652410507,
-0... |
possible\tto\n\tdetect\tdisease\tsusceptibilities\tearly\tand\ttailor\tinterventions\tthat\tcan\tprevent\tchronic\nconditions\tfrom\tmanifesting.\tSee\tthe\tNational\tInstitutes\tof\tHealth\twebsite\ton\tresearch\ton\tsocial\nepigenomics\tto\taddress\thealth\tdisparities\tfor\tinformation\ton\tthe\ttypes\tof\tresearch\... | [
-0.015139729715883732,
-0.05093207210302353,
0.07039447128772736,
-0.007610522210597992,
-0.09107045084238052,
-0.008128887973725796,
0.08910563588142395,
-0.029380107298493385,
-0.04257361590862274,
0.08401788771152496,
0.08098281919956207,
-0.07575598359107971,
0.035932011902332306,
0.01... |
Modes\tof\tinheritance\nThree\tprocesses\tinfluence\thow\ttraits\tare\ttransmitted\tfrom\tone\tgeneration\n\tto\tthe\tnext:\tmendelian\ninheritance,\tmitochondrial\tinheritance,\tand\tepigenetic\tinheritance.\nMendelian\tinheritance\nEach\tcell’s\tnucleus\tcontains\ta\tcomplete\tset\tof\tgenetic\tmaterial\t(genome),\td... | [
-0.028752487152814865,
-0.05169441178441048,
0.01211786363273859,
-0.04497745633125305,
-0.07696844637393951,
-0.027190035209059715,
0.028786392882466316,
0.002697607036679983,
-0.02379208244383335,
0.04785089194774628,
0.09818438440561295,
-0.08679056912660599,
0.028335796669125557,
0.001... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.