0 stringlengths 12 494 | embeddings listlengths 384 384 |
|---|---|
to\tcut\tthe\tDNA.\tCas9\tis\tmost\toften\tused,\tbut\tother\tenzymes\tcan\talso\tbe\tcombined\twith\tCRISPR\nsuch\tas\tCas11\tand\tCpf1.\tThe\tcell’s\tDNA\trepair\tmechanism\tthen\trepairs\tthe\tbreak,\tintroducing\nchanges\talso\tencoded\n\ton\tthe\tguide\tRNA.\nSince\tCRISPR\tis\tmuch\tmore\taccurate\tand\tefficient... | [
-0.01800866611301899,
-0.03497966006398201,
0.03992520272731781,
-0.060946572571992874,
-0.09608221054077148,
0.004300678614526987,
0.07281335443258286,
-0.012598908506333828,
-0.013623262755572796,
0.06235164403915405,
0.07005908340215683,
-0.0012748049339279532,
0.06567391753196716,
-0.0... |
researchers\tare\texploring\tthe\tpossibility\tof\tusing\tit\tto\tcorrect\tgenetic\tdiseases\tin\thumans.\tSingle-\ngene\tdisorders\tsuch\tas\tsickle\tcell\tanemia,\tcystic\tfibrosis,\tand\tother\tmendelian\tdisorders\tare\tlikely\nfirst\tcandidates\tfor\tthis\ttreatment.\tHowever,\treports\tof\tchanges\tin\tnontargete... | [
-0.04722093790769577,
0.007409136742353439,
0.04899793118238449,
-0.015477936714887619,
-0.04194597154855728,
-0.027216387912631035,
0.025127587839961052,
0.04067881032824516,
0.014713946729898453,
0.06258685886859894,
0.07602893561124802,
0.001535036601126194,
0.03224601224064827,
0.03606... |
of\tthe\ngenome\t(called\toff-target\teffects)\traise\tthe\tpossibility\tof\tunintended\tconsequences\tsuch\tas\tcancer\nor\tother\tdiseases.\tThe\tearly\tfailures\tof\tgene\ttherapy\tand\tthe\tavailability\tof\tcurrent\tdisease-\nmanaging\ttherapies\thave\tled\thealth\tresearchers\tto\tproceed\twith\tcaution.\tThe\tap... | [
0.01937367580831051,
-0.095174141228199,
0.06136054918169975,
-0.01931663602590561,
-0.06409594416618347,
0.01426663901656866,
0.07854141294956207,
-0.01678188145160675,
0.013170035555958748,
0.03905029222369194,
0.0585930161178112,
-0.03488408774137497,
0.0783127173781395,
0.0430780835449... |
technology\tto\tcomplex\tdiseases\tand\tthe\tline\tbetween\tfighting\tdisease\tand\tunnecessary\nenhancement\talso\n\tremain\tprovocative\ttopics.\nThe\ttechnology\talso\topens\tdebate\tabout\tresponsible\tways\tto\tedit\thuman\tgenomes.\tEditing\ta\nperson’s\town\tcells,\tknown\tas\tsomatic\tediting,\taffects\tonly\tt... | [
0.03170030564069748,
-0.03470772132277489,
0.09011933207511902,
-0.06711045652627945,
-0.09661172330379486,
0.030853310599923134,
0.06214293837547302,
-0.009360588155686855,
-0.040070824325084686,
0.09380579739809036,
0.06416104733943939,
-0.012974048033356667,
0.08279599249362946,
0.00549... |
(sperm\tand\teggs)\tor\tthose\tof\tembryos\thas\tthe\tpotential\tto\taffect\tfuture\tgenerations.\tUnregulated\nexperiments\ton\thuman\tembryos\thave\talready\toccurred,\tspurring\tthe\tneed\tfor\tresearchers,\npolicymakers,\tand\tthe\tpublic\tto\tdiscuss\tthe\tethics,\tlimits,\tand\tpotential\tof\tthis\tpowerful\ntech... | [
-0.027369199320673943,
-0.022482555359601974,
0.036610789597034454,
-0.03360224887728691,
-0.05736027657985687,
-0.042307525873184204,
0.07952806353569031,
0.01050414890050888,
-0.03531701862812042,
0.11187876015901566,
0.13216519355773926,
-0.0403902642428875,
-0.02996833249926567,
0.0346... |
technology.\nThe\trate\tof\tprogress\tof\tapplying\tgenomics\tin\tclinical\tapplications\tis\tassociated\tstrongly\twith\nprogress\tin\tidentifying\tassociations\tbetween\tdiseases\tand\t\nsingle\tnucleotide\tpolymorphisms\n(SNPs,\tpronounced\t“snips”).\tOnce\ta\tstrong\tassociation\thas\tbeen\tdetermined,\tdiagnostic\... | [
0.01483150478452444,
-0.08756230026483536,
-0.002388638909906149,
-0.05768116936087608,
-0.07863784581422806,
-0.016973817721009254,
0.04888578876852989,
0.03967403993010521,
-0.0009065374033525586,
0.10737605392932892,
0.08948397636413574,
-0.03650661185383797,
-0.03377057984471321,
0.053... |
appropriate\n\tdiet\tand\tlifestyle\tinterventions\tcan\tbe\tdeveloped\tand\ttested\tfor\tefficacy.\tAs\tthe\tname\tfor | [
0.028489358723163605,
-0.019117873162031174,
0.031023351475596428,
-0.029892630875110626,
-0.007820534519851208,
0.001340476213954389,
0.17316946387290955,
-0.00424105953425169,
0.0025575885083526373,
0.058516599237918854,
0.05699987709522247,
-0.04486057162284851,
0.0344771146774292,
0.08... |
this\tgenetic\tvariation\tsuggests,\tthe\tchange\tinvolves\ta\tsingle\tnucleotide.\tThe\tinitial\tmolecular\napproach\tto\tassociating\tmutations\twith\tsusceptibility\tto\tdisease\twas\tto\tlook\tfor\tSNPs\t(changes)\tin\ngenes\tthat\tencoded\timportant\tmetabolic\tproteins.\tThis\tapproach\thas\tbeen\tsomewhat\tsucce... | [
0.0028826340567320585,
-0.06790135055780411,
0.04839690402150154,
-0.03620615601539612,
-0.08429986983537674,
0.0015783036360517144,
0.0736883208155632,
0.01813209429383278,
-0.000014987689610279631,
0.10791139304637909,
0.11946220695972443,
-0.04358275234699249,
-0.03193625807762146,
0.04... |
not\tsufficiently\n\tsuccessful\tin\tunderstanding\tthe\tgenetic\tand\tenvironmental\tcomplexity\tof\tchronic\ndisorders.\tAs\ta\tresult,\tmore\trecently\tthe\tspeed\tof\twhole\tgenome\tsequencing\thas\tincreased\nsubstantially\tand\tthe\tcost\thas\tdecreased,\twhich\thave\tallowed\ta\tshift\tto\t\ngenome-wide\tassocia... | [
0.029346011579036713,
-0.045347247272729874,
0.09813486784696579,
-0.010823861695826054,
-0.08518746495246887,
-0.011680715717375278,
0.054173290729522705,
-0.042860813438892365,
0.015252177603542805,
0.07188474386930466,
0.10554598271846771,
-0.08068712055683136,
-0.013361800462007523,
0.... |
genome-wide\tassociation\nstudies\t(GWAS)\n\tas\tthe\tpreferred\tgenomic\ttool\tfor\tdetecting\tSNPs.\tGWAS\tallows\tthe\tdetection\tof\npatterns\tof\tmultiple\tSNPs\tassociated\n\twith\ta\tdisease\tand\tis\tparticularly\tuseful\tfor\tcomplex\tdisorders.\nSee\t\nBox\t6.11\n\tfor\tadditional\tinformation.\nBOX\t6.11\nDe... | [
-0.039164938032627106,
-0.05774290859699249,
0.013353914953768253,
-0.05916740000247955,
-0.0489480160176754,
-0.02043968252837658,
0.016525238752365112,
-0.00671844556927681,
-0.033659547567367554,
0.09908244758844376,
0.10985326766967773,
-0.07240034639835358,
-0.03207498416304588,
0.036... |
BOX\t6.11\nDetecting\tGene\tVariants:\tCandidate\tGene\tvs.\tGWAS\nFor\ta\tgene\tvariant\tto\tbe\tclinically\tuseful,\tit\tmust\tbe\twell-characterized\tin\tterms\tof\tits\tassociation\nwith\ta\tdisease\tstate,\toccur\tfrequently\tin\tthe\tpopulation\tbeing\tstudied\t(and,\tpreferably,\tin\tmultiple\npopulations),\tand... | [
0.047225527465343475,
-0.04120532423257828,
0.06318990886211395,
-0.029160376638174057,
-0.11573151499032974,
0.025503449141979218,
0.07804761081933975,
-0.03856080397963524,
0.0057373964227736,
0.08008105307817459,
0.09183239936828613,
-0.06504012644290924,
0.0019433482084423304,
0.020809... |
populations),\tand\thave\ta\n\twell-documented\teffective\ttherapeutic\tintervention.\tThere\thave\tbeen\ntwo\tmain\tapproaches\tto\tidentifying\tgene\tvariants\tthat\tare\tassociated\twith\tincreased\trisk\tof\ndeveloping\tcommon\tdiseases:\tcandidate\tgene\tstudies\tand\tgenome-wide\tassociation\tstudies\n(GWAS).\tTh... | [
0.04114144667983055,
-0.027119778096675873,
0.05295410752296448,
-0.0013921060599386692,
-0.05767296999692917,
0.032373398542404175,
0.0794650986790657,
-0.03622257336974144,
-0.016690585762262344,
0.12575191259384155,
0.12148667126893997,
-0.13794614374637604,
-0.05318598449230194,
-0.007... |
(GWAS).\tThe\t\ncandidate\tgene\tapproach\n\twas\tthe\toriginal\ttool.\tIt\tfocuses\ton\tfunctional\tvariants\nand\tpositional\tvariants.\tFunctional\tvariants\tresult\tfrom\n\tmutations\tin\tgenes\twhose\tproducts\tare\nknown\tto\tbe\tinvolved\tin\tthe\tmechanisms\tunderlying\tthe\tdisease\tof\tinterest.\tThe\tpositio... | [
0.04376647248864174,
-0.0677882581949234,
0.09449420869350433,
-0.03448397293686867,
-0.1420518308877945,
-0.018189774826169014,
0.06134295463562012,
-0.017732303589582443,
-0.010034897364675999,
0.11834689229726791,
0.12141333520412445,
-0.043414387851953506,
-0.009335142560303211,
0.0151... |
approach\tis\tsimilar\tbut\tsearches\tfor\tvariants\tthat\tare\tphysically\tclose\tto\tgenes\tknown\tto\tbe\ninvolved\tin\tthe\tunderlying\tmechanisms.\tCandidate\tgene\tstudies\thave\tthe\tlimitation\tthat\tthey’re\ndependent\ton\tknowledge\tof\tthe\tmechanisms\tunderlying\tthe\tdisease\tof\tinterest.\tIf\tthe\n\tmech... | [
0.044918861240148544,
-0.03795717656612396,
0.08164265751838684,
-0.007364490535110235,
-0.101307213306427,
-0.020289694890379906,
0.03489839285612106,
-0.03340690955519676,
-0.024983741343021393,
0.10706023126840591,
0.06541960686445236,
-0.04476867988705635,
0.034765779972076416,
0.02964... |
mechanisms\nhave\tnot\tbeen\tthoroughly\tdefined,\tit\tis\tlikely\tthat\tnovel\tgenes\twill\tnot\tbe\tdetected.\tFurther,\ta\nlarge\tcohort\tis\toften\tneeded\tin\torder\tto\tinclude\tsufficient\tsubjects\thomozygous\tfor\tthe\trisk\tallele.\nCandidate\tgenes\thave\tbeen\tmost\tsuccessful\tfor\tsingle\tgene\tdisorders. | [
-0.011754202656447887,
-0.04785611107945442,
0.019078243523836136,
-0.023531142622232437,
-0.08245420455932617,
0.00773374829441309,
0.028336286544799805,
-0.006180265918374062,
0.03107098489999771,
0.11158948391675949,
0.09244099259376526,
-0.03391832858324051,
-0.0032615282107144594,
0.0... |
Candidate\tgenes\thave\tbeen\tmost\tsuccessful\tfor\tsingle\tgene\tdisorders.\nLifestyle-related\tchronic\tdiseases,\thowever,\ttend\tto\tbe\tcomplex\ttraits\tand\tthe\tcomplexity\tis\nfurther\tcompounded\tby\tthe\n\tepigenetic\tcomponent.\tDevelopment\tof\tthese\tdiseases\ttypically\nrequires\tthe\tinteraction\tof\ta\... | [
0.014444182626903057,
-0.023058945313096046,
0.0713328868150711,
-0.03162006661295891,
-0.04608627036213875,
0.05950335040688515,
0.024743031710386276,
-0.030518118292093277,
-0.0573590062558651,
0.07659786194562912,
0.10097407549619675,
-0.06672512739896774,
0.053621843457221985,
0.037975... |
factors.\tThese\tfactors\tare\ttypically\tmodifiable\tand\tinvolve\tlifestyle\tchoices\tsuch\tas\tthe\tfood\twe\neat,\twhether\twe\texercise\tregularly,\thow\twell\twe\tmanage\tour\tthoughts\tand\temotions,\tthe\tquality\nof\trelationships\tand\tsystems\tof\tmeaning,\tthe\tquality\n\tand\tquantity\tof\tour\tsleep,\tand... | [
0.06512445211410522,
-0.017807811498641968,
0.07451780885457993,
0.010434729047119617,
-0.10517456382513046,
-0.009105966426432133,
0.030417658388614655,
-0.019907355308532715,
0.001733320066705346,
0.047083329409360886,
0.07854849100112915,
-0.05590604618191719,
0.01576879806816578,
0.048... |
and\tquantity\tof\tour\tsleep,\tand\tour\texposure\nto\ttoxins\tsuch\tas\ttobacco\tsmoke\tand\tother\tair\tpollution,\tfood-borne\ttoxic\tchemicals,\tand\talcohol.\nWith\tthe\trapid\tadvances\tin\tgenetic\ttechnology\tit\thas\tbeen\tpossible\tand\teconomically\tfeasible\tto\nscan\tthe\tentire\tgenome\tin\tsearch\tof\tc... | [
0.038729436695575714,
-0.03078259341418743,
0.06973136216402054,
-0.0317758247256279,
-0.0809335857629776,
-0.016896409913897514,
0.11060035973787308,
-0.057966455817222595,
-0.01487287599593401,
0.06259991228580475,
0.09063448011875153,
-0.05793583393096924,
0.05980079621076584,
0.0246051... |
involve\ta\tset\tof\tindividuals\twith\tthe\tsame\tdiagnosis\tand\tsearch\n\tfor\tcommon\tgenetic\tvariations\namong\tthese\tindividuals\tor\tbetween\tpopulations.\tThere\tare\tno\tpredetermined\ttarget\tgenes\tand\nthousands\tof\tvariants\tand\tthousands\tof\tindividuals\tcan\tbe\tinvestigated,\twhich\thas\tgreatly\ni... | [
0.024976303800940514,
-0.019233912229537964,
0.06689580529928207,
-0.016451280564069748,
-0.06666501611471176,
0.02394106425344944,
0.11223883926868439,
-0.06323341280221939,
-0.019059952348470688,
0.083772212266922,
0.11196240037679672,
-0.07382462173700333,
0.04848649352788925,
0.0408959... |
increased\tthe\tspeed\tat\twhich\tgene\tvariants\thave\tbeen\tdetected.\tThe\t\nCatalog\tof\tPublished\nGenome-Wide\tAssociation\tStudies\n\tcan\tbe\tsearched\tby\tdiseases\tof\tinterest\tto\tlearn\twhich\tgene\nvariants\n\thave\tbeen\tidentified\tto\tdate.\tThe\tlarge\tamounts\tof\tdata\tgenerated\tby\teither\tapproac... | [
0.05695405974984169,
-0.11057794839143753,
0.05641567334532738,
-0.031263671815395355,
-0.10959631204605103,
0.00020760834740940481,
0.07026919722557068,
-0.001075289212167263,
0.02323113940656185,
0.08397990465164185,
0.10825057327747345,
-0.013335653580725193,
0.007503624074161053,
0.012... |
but\tparticularly\tby\tthe\tGWAS\tapproach,\tgreatly\tbenefits\tfrom\tthe\tdevelopment\tof\tbioinformatics\nand\tits\thigh-capacity\tcomputer\torganization\tand\tanalysis.\nIn\taddition\tto\tSNPs,\tother\ttypes\tof\tvariations\talso\tmay\tplay\tan\timportant\trole\tin\tthe\tgenotypic\tand\nphenotypic\tvariation\tamong\... | [
-0.012332823127508163,
-0.06425262987613678,
0.041117649525403976,
-0.06380565464496613,
-0.07123883068561554,
-0.01294615212827921,
0.06550313532352448,
-0.022337540984153748,
-0.010433352552354336,
0.09161810576915741,
0.12069140374660492,
-0.024768074974417686,
-0.02323373779654503,
0.0... |
than\tone\tnucleotide\t(deletions\tand\ninsertions,\trespectively),\tduplication\tof\tnucleotide\tsequences,\tcopy\tnumber\tvariants,\tand\nrestructuring\tof\tregions\twithin\ta\tchromosome\t(inversions\tand\ttranslocations)\talso\thave\timportant\nconsequences\tto\tfunction.\tThe\tmost\trecent\tcataloging\tof\thuman\t... | [
-0.061893679201602936,
-0.0697856917977333,
0.028779055923223495,
-0.08795353770256042,
-0.10917296260595322,
-0.049630168825387955,
0.0017867775168269873,
0.010379157960414886,
0.06602813303470612,
0.09512223303318024,
0.10469403117895126,
-0.018614083528518677,
-0.027034608647227287,
0.0... |
Genomes\tProject\t(\nwww.internationalgenome.org\n)\t(\nBox\t6.12\n).\tThe\tearlier\tSNP\tcataloging\n\twas\npredominantly\tof\tindividuals\tof\tEuropean\tdescent\twith\tsome\tAfrican\tAmerican\tand\tAsian\nrepresentation\tand\tis\tnow\tundergoing\texpansion\tto\tmultiple\tethnic\tgroups.\nDisease\tat\tthe\tchromosomal... | [
-0.03737722709774971,
-0.05383705720305443,
0.008693541400134563,
-0.02406020276248455,
-0.03110409900546074,
-0.041987884789705276,
-0.004803680814802647,
-0.04572130739688873,
0.0003984293434768915,
0.08556833118200302,
0.12736795842647552,
-0.0516233965754509,
-0.030395587906241417,
0.0... |
Disease\tat\tthe\tchromosomal\tlevel\nChange\tin\tthe\tnumber\tof\tchromosomes,\tor\tthe\tarrangement\tof\tDNA\twithin\ta\tchromosome,\tis\talmost\nalways\tdetrimental\tand\toften\tfatal\tto\tthe\tindividual.\tChromosomal\tdisorders\tare\tdetected\tby\tmeans\nof\ta\t\nkaryotype\n,\ta\tvisualization\tof\tall\tthe\tchrom... | [
-0.015808217227458954,
-0.03602643311023712,
0.06716196238994598,
-0.013261441141366959,
-0.14239774644374847,
0.005204000044614077,
0.06513998657464981,
-0.0042687514796853065,
0.011954979971051216,
0.09718354046344757,
0.12730026245117188,
-0.02258359268307686,
0.015046955086290836,
0.01... |
change\tin\tthe\tnumber\tor\tstructure\tof\ta\tchromosome\tare\toften\tlethal\tevents\tbecause\tchromosomes\ncontain\tmultiple\tgenes\tand\tthe\tensuing\tchaos\tof\thaving\ttoo\tlittle\tor\ttoo\tmuch\tinformation,\tor\ninformation\tbeing\texpressed\tat\tthe\twrong\ttime,\tis\tdetrimental\tto\tthe\torganism.\tHowever,\t... | [
-0.04498482868075371,
0.018893536180257797,
0.050242457538843155,
-0.056774307042360306,
-0.08547491580247879,
0.017482437193393707,
0.07784442603588104,
-0.054926831275224686,
0.023499850183725357,
0.08332772552967072,
0.07336920499801636,
-0.006865456700325012,
0.03998716548085213,
-0.00... |
possible\tthat\tparts\tof\tchromosomes\n\twill\tbreak\taway\tand\tattach\tto\tanother\tchromosome\tor\tthat\ta\nregion\tof\ta\tchromosome\twill\tbe\tduplicated.\tSuch\tevents\tare\tnot\talways\tlethal\tbut\tdo\ttypically\tcause\nabnormal\tsymptoms.\tThere\tare\tnumerous\tchromosomal\taberrations\tthat\thave\tbeen\tdefi... | [
-0.009473573416471481,
-0.03276383504271507,
0.026733743026852608,
-0.04425406455993652,
-0.07623738050460815,
0.00033624283969402313,
0.0690532922744751,
-0.0026648787315934896,
0.019818030297756195,
0.06669875979423523,
0.05737578496336937,
-0.023808952420949936,
0.04336654394865036,
0.0... |
which\thave\tnutritional\timplications\tsuch\tas\tassistance\twith\tfeeding.\tDescriptions\tof\tthe\tchanges\tand\ntheir\tconsequences\tcan\tbe\tfound\tin\tclinical\n\tgenetics\ttextbooks\tas\twell\tas\tonline\tin\tresources\tsuch\tas\nthe\tGenetic\tand\tRare\tDiseases\tInformation\tCenter\tand\tthe\tMendelian\tInherit... | [
0.02200561948120594,
-0.03414193168282509,
0.06200285255908966,
-0.01897113211452961,
-0.10995540767908096,
-0.005056705791503191,
0.036404144018888474,
-0.021914824843406677,
0.028652222827076912,
0.09078686684370041,
0.09791145473718643,
-0.04461891949176788,
0.03191821649670601,
0.01343... |
compendium.\nAn\texample\tof\ta\tnonfatal\tchromosomal\tabnormality\tis\ttrisomy\t21\t(Down’s\tsyndrome).\tTypically\nseen\tis\tan\textra\tcopy\tof\tthe\twhole\tchromosome\tresulting\tfrom\tan\terror\tin\tdistributing\tthe\nchromosomes\tduring\tsperm\tor\tegg\tformation.\tHowever,\tthe\tcharacteristics\n\tof\tDown’s\ts... | [
0.02660728618502617,
-0.029261916875839233,
0.0731867179274559,
0.003960107918828726,
-0.12202342599630356,
-0.0023958515375852585,
0.08107984066009521,
-0.022676311433315277,
0.01942458190023899,
0.046898066997528076,
0.07830093055963516,
-0.017670724540948868,
0.018413960933685303,
0.012... |
of\tDown’s\tsyndrome\tare\ndue\tto\ta\tsmall\tregion\tof\tchromosome\t21,\tso\tthat\teven\tif\tonly\tthat\ttiny\tpiece\tof\tDNA\tis\tpresent\tin\ntriplicate,\tthe\tsyndrome\tresults.\tOther\tdevelopmental\tsyndromes\tare\tcaused\tby\tthe\tloss\tof\ta\tportion | [
0.044661831110715866,
0.002392351860180497,
0.06336365640163422,
-0.04398014023900032,
-0.0858956128358841,
0.052938349545001984,
0.04415648430585861,
-0.0025330425705760717,
-0.003437866223976016,
0.030760983005166054,
0.013376754708588123,
-0.017807813361287117,
-0.0044512259773910046,
0... |
of\ta\tchromosome\t(a\tpartial\tdeletion).\tIn\tBeckwith-Wiedemann’s\tsyndrome\t(a\tchromosome\t11\ndeletion),\tchanges\tare\tcharacterized\tby\torgan\tovergrowth,\tincluding\tan\toversized\n\ttongue,\twhich\nleads\tto\tfeeding\tdifficulties\tand\tundernutrition.\nNutrition\tprofessionals\tplay\tan\timportant\trole\tin... | [
-0.005806973669677973,
-0.015105735510587692,
0.06306660920381546,
0.02932090498507023,
-0.08601751178503036,
0.018482083454728127,
0.09864658862352371,
0.012927591800689697,
0.00021682633087038994,
0.039989929646253586,
0.1146133691072464,
-0.016516054049134254,
0.0025925785303115845,
0.0... |
because\tthese\tindividuals\toften\thave\toral-motor\tproblems\tthat\taffect\ttheir\tnutritional\tstatus\tand\ncause\tgrowth\tproblems\tin\tearly\tlife.\tLater\tin\tdevelopment,\tbody\tweight\tmay\tbecome\tan\tissue,\tand\nnutrition\ttherapy\tis\thelpful\tin\tcontrolling\n\tweight,\tdiabetes,\tand\tcardiovascular\tcomp... | [
0.02005527727305889,
-0.04740637168288231,
0.0838753953576088,
0.035317473113536835,
-0.012147040106356144,
0.03519756719470024,
0.10488931089639664,
0.055425841361284256,
-0.02145117148756981,
0.12115462124347687,
0.09215275943279266,
-0.010434482246637344,
-0.026618661358952522,
0.045238... |
weight,\tdiabetes,\tand\tcardiovascular\tcomplications.\nVarying\tdegrees\tof\tmental\tinsufficiency\toften\tcomplicate\ttherapy.\tNutrition\tprofessionals\tcan\thelp\nmitigate\tthe\tdetrimental\teffects\tof\tthese\tdisorders\ton\tnutritional\tstatus\t(see\t\nChapter\t43\n).\nDisease\tat\tthe\tmitochondrial\tlevel | [
0.015123169869184494,
-0.09303069114685059,
0.021307211369276047,
0.05646470561623573,
-0.10522390156984329,
-0.022655120119452477,
0.07945612818002701,
0.07441139966249466,
-0.03420760855078697,
0.03043638914823532,
0.06348346173763275,
-0.01234186626970768,
0.0057717119343578815,
0.04501... |
Chapter\t43\n).\nDisease\tat\tthe\tmitochondrial\tlevel\nDue\tto\tthe\tmajor\trole\tthat\tmitochondria\tplay\tin\tenergy\tproduction,\talterations\tin\tmtDNA\tare\nfrequently\tdegenerative\n\tand\thave\tvaried\tclinical\tmanifestations\tbecause\tof\tthe\tmultiple\tcopies\tof\nmtDNA,\tnot\tall\tof\twhich\tmay\tcontain\t... | [
0.0025584944523870945,
0.005469163414090872,
0.07952067255973816,
-0.06510859727859497,
-0.070771224796772,
0.024388425052165985,
0.03284674137830734,
0.005140612833201885,
-0.0262090265750885,
0.08051583170890808,
0.15950874984264374,
-0.01877773553133011,
0.04702598229050636,
-0.00595032... |
age\tand\tinclude\tneurologic\tdiseases,\tcardiomyopathies,\tand\tskeletal\tmyopathies.\tAn\tincreasing\nnumber\tof\tdiseases\tare\tbeing\tlinked\tto\tmutations\tin\tmtDNA.\tOne\tof\tthe\tearliest\tdisorders\tto\tbe\ntraced\tto\tmtDNA\tis\tWolfram’s\tsyndrome,\ta\n\tform\tof\tdiabetes\twith\tassociated\tdeafness.\tSubs... | [
-0.0075487601570785046,
0.01543987262994051,
0.0893513634800911,
-0.004861313384026289,
-0.09628532081842422,
-0.008674168027937412,
0.041112467646598816,
0.011605395004153252,
-0.08459379523992538,
0.06796382367610931,
0.13218273222446442,
-0.03842417523264885,
-0.008531911298632622,
-0.0... |
form\tof\tdiabetes\twith\tassociated\tdeafness.\tSubsequently,\ngene\tvariants\thave\tbeen\tfound\tthat\trelate\tto\teach\tof\tthe\tcomponents\tof\tthe\toxidative\nphosphorylation\tpathway.\tThe\tphysiologic\tconsequences\tof\tthese\tmutations\ttypically\tinvolve\torgans\nthat\thave\ta\thigh\tdemand\tfor\tenergy,\tsuch... | [
0.057205043733119965,
-0.10444987565279007,
0.037306323647499084,
-0.03289417549967766,
-0.1463959962129593,
0.01743779517710209,
0.08347219228744507,
-0.009246628731489182,
-0.014153126627206802,
0.09081254154443741,
0.0779583752155304,
-0.016242340207099915,
0.05080205202102661,
0.061559... |
Institutes\tof\tHealth\tGenetics\tHome\tReference\twebsite\tfor\tinformation\n\ton\tmtDNA-based\tdisorders\nand\tMITOMAP,\ta\thuman\tmitochondrial\tgenome\tdatabase,\tfor\tspecifics\ton\thuman\tmtDNA\tvariants.\nDisease\tat\tthe\tmolecular\tlevel\nThe\tmajority\tof\tdisease\tconditions\tassociated\twith\tgenomics\tinvo... | [
-0.03790374845266342,
-0.053652338683605194,
0.015394785441458225,
-0.06257635354995728,
-0.08047559857368469,
-0.02333121933043003,
-0.03026115521788597,
0.020605111494660378,
-0.012762044556438923,
0.07690086215734482,
0.13219568133354187,
-0.035151030868291855,
0.022119997069239616,
0.0... |
Changes\tto\tthe\tDNA\ttypically\tinvolve\ta\tsingle\tnucleotide\tchange\tor\tseveral\tnucleotides\twithin\ta\nsingle\tgene\tthrough\tsubstitutions,\tadditions,\tor\n\tdeletions\tin\tthe\tregulatory,\tpromoter,\tor\tcoding\nregions.\tAlterations\tin\tthe\tregulatory\tor\tpromoter\tregion\tmay\tincrease\tor\tdecrease\tt... | [
-0.043599870055913925,
-0.06322139501571655,
0.019947443157434464,
-0.07753124833106995,
-0.11608555912971497,
0.00595859857276082,
0.03355344757437706,
0.013971565291285515,
0.00899029802531004,
0.1267375349998474,
0.12784899771213531,
-0.013418934307992458,
-0.023152748122811317,
0.02155... |
protein\tproduced\tor\talter\tthe\tability\tof\tthe\tgene\tto\trespond\tto\tenvironmental\tsignals.\tAlterations\tin\nthe\tcoding\tregion\tmay\taffect\tthe\tamino\tacid\tsequence\tof\tthe\tprotein,\twhich\tin\tturn\tcan\taffect\tthe\nconformation\tand\tfunction\tof\tthe\tprotein\tand\tthereby\n\tthe\tfunctioning\tof\tt... | [
0.005078812595456839,
-0.08810318261384964,
0.049546368420124054,
-0.0300347488373518,
-0.0694291815161705,
0.022435175254940987,
0.09934382140636444,
-0.0046216812916100025,
0.030313042923808098,
0.07342741638422012,
0.10084903985261917,
-0.033272866159677505,
0.012664669193327427,
0.0476... |
the\tfunctioning\tof\tthe\torganism.\tBecause\tthe\nmajority\tof\thuman\tgenes\treside\ton\tchromosomes,\tgene\tvariations\tare\ttransmitted\taccording\tto\nmendelian\tinheritance\n\tand\tare\tsubject\tto\tmodification\tfrom\tepigenetic\tmarkings.\nAutosomal\tdominant\tsingle-gene\tdisorders\tthat\thave\tnutritional\ti... | [
-0.012708782218396664,
-0.02927812561392784,
0.04514555260539055,
-0.007600150536745787,
-0.08048400282859802,
-0.0002816051128320396,
0.015832558274269104,
-0.01325832400470972,
0.020659862086176872,
0.09099835157394409,
0.11944472044706345,
-0.06041839346289635,
-0.0012388193281367421,
-... |
may\tresult\tin\tdevelopmental\tdisabilities,\toral-motor\tproblems,\tsusceptibility\tto\n\tweight\tgain,\tand\ndifficulties\twith\tconstipation.\tExamples\tinclude\tAlbright\thereditary\tosteodystrophy,\twhich\tcommonly\nresults\tin\tdental\tproblems,\tobesity,\thypocalcemia,\tand\thyperphosphatemia;\tchondrodysplasia... | [
-0.006316226441413164,
-0.009808095172047615,
0.0735398530960083,
0.012640034779906273,
-0.034779392182826996,
-0.008674890734255314,
0.07479055970907211,
0.0017012740718200803,
-0.0526139922440052,
0.08163317292928696,
0.12496434897184372,
-0.01890210434794426,
0.05157262459397316,
0.0326... |
often\tresult\tin\toral-motor\tproblems\tand\tobesity;\tand\tMarfan\tsyndrome,\twhich\tinvolves\tcardiac\ndisease,\texcessive\tgrowth,\tand\tincreased\tnutritional\tneeds.\tFamilial\thypercholesterolemia\t(type\n\t2\nfamilial\tdyslipidemia)\tresults\tfrom\ta\tdefective\tlow-density\tlipoprotein\treceptor\t(\nLDLR\n\tge... | [
-0.006877985317260027,
-0.056046273559331894,
-0.014617351815104485,
-0.011571415700018406,
-0.07330361753702164,
-0.03512919321656227,
0.037210863083601,
0.07784406840801239,
-0.02439635619521141,
0.015543544664978981,
0.10295474529266357,
-0.005802739877253771,
0.02025507017970085,
-0.01... |
LDLR\n\tgene),\ntransmitted\tas\tan\tautosomal\tdominant\ttrait.\tSymptoms\tinclude\televated\tlevels\tof\ttotal\tcholesterol,\nelevated\tlevels\tof\tLDL\tcholesterol,\tand\tincreased\trisk\tof\tatherosclerosis.\nAutosomal\trecessive\tdisorders\tare\tmore\tcommon.\tThey\twere\ttraditionally\tdetected\tbecause\tthe\nmut... | [
0.02083480916917324,
-0.11030013859272003,
0.01828131079673767,
-0.036328185349702835,
-0.12807542085647583,
-0.01923361048102379,
0.05234391614794731,
0.03679341822862625,
0.012910020537674427,
0.046687137335538864,
0.1075250655412674,
-0.025641247630119324,
-0.004370012320578098,
0.02034... |
mutation\thad\ta\tdetrimental\teffect\n\ton\tthe\tnewborn\tinfant\tthat\tled\tto\tserious\tdevelopmental\nconsequences\tor\tdeath.\tSickle\tcell\tanemia\tis\tan\texample\tof\tan\tautosomal\trecessive\tdisease,\tcaused\nby\tinheriting\ttwo\tcopies\tof\tthe\tvariant\t\nHBB\n\tgene.\tMetabolic\tdisorders\tof\tamino\tacid,... | [
-0.007869735360145569,
-0.08226055651903152,
0.016671132296323776,
-0.045514993369579315,
-0.11638051271438599,
-0.030590135604143143,
0.060296133160591125,
0.0024008338805288076,
-0.034102268517017365,
0.10848771035671234,
0.11227741837501526,
-0.05000094324350357,
-0.013332225382328033,
... |
HBB\n\tgene.\tMetabolic\tdisorders\tof\tamino\tacid,\tcarbohydrate,\nand\tlipid\tmetabolism,\tdesignated\tas\tinborn\terrors\tof\tmetabolism\t(IEM),\tare\tsimilarly\theritable\tand\nassociated\twith\ta\tparticular\tmutation.\tIEM\tdisorders\n\tare\tthe\tearliest\tknown\texamples\tof\tnutritional\ngenomics,\tand\tdietar... | [
0.012935750186443329,
-0.007985279895365238,
0.05470868945121765,
-0.028962448239326477,
-0.09160532057285309,
-0.027181435376405716,
0.0506431870162487,
0.0021465711761265993,
0.02824740670621395,
0.0540379099547863,
0.11385843902826309,
-0.018955755978822708,
0.0387643501162529,
-0.00486... |
Chapter\t42\n).\tA\tbrief\noverview\tof\tIEM\tfrom\ta\tgenetic\tperspective\tis\tincluded\there\tto\temphasize\tthe\timportant\trole\tof\tthe\nnutrition\tprofessional\tin\trestoring\thealth\tto\tthese\tindividuals\tand\tto\tcontrast\tIEM\twith\tchronic\ndisorders,\twhich\tresult\tfrom\tthe\tsame\ttype\tof\tgenetic\tcha... | [
0.051969610154628754,
-0.014209561049938202,
0.04747602343559265,
-0.04825817421078682,
-0.10772304981946945,
0.039096709340810776,
0.05959578976035118,
-0.00039023670251481235,
0.022826476022601128,
0.08924500644207001,
0.10966770350933075,
-0.007071524392813444,
0.06827795505523682,
-0.0... |
affect\tfunction\tless\tseverely.\tA\nclassic\texample\tof\tan\tIEM\tof\tamino\tacid\tmetabolism\tis\tphenylketonuria\t(PKU),\twhich\tis\tan\tautosomal\nrecessive\tdisorder.\tPKU\tresults\tfrom\ta\tmutation\tin\tthe\tgene\tcoding\tfor\tthe\tenzyme\tphenylalanine\nhydroxylase,\tleading\tto\tan\tinability\tto\tconvert\tp... | [
-0.004477953538298607,
-0.06465994566679001,
0.02382465824484825,
-0.015234879218041897,
-0.06191454455256462,
0.0037938952445983887,
0.0763765424489975,
0.061723653227090836,
-0.024840664118528366,
0.03991633653640747,
0.10278564691543579,
0.013234883546829224,
0.0002922311832662672,
0.06... |
of\tphenylalanine\tenables\tindividuals\twith\tPKU\tto\tlive\tinto\tadulthood\n\tand\tenjoy\ta\tquality\tlife.\nHereditary\tfructose\tintolerance\t(HFI)\tis\tanother\texample\tof\tan\tautosomal\trecessive\tIEM\tof\ncarbohydrate\tmetabolism.\tA\tmutation\tin\tthe\t\nALDOB\n\tgene\tencoding\taldolase\tB\t(fructose-1,6- | [
-0.01838589645922184,
-0.06038832291960716,
-0.006825456861406565,
0.0040527707897126675,
-0.07479588687419891,
0.03306228294968605,
0.09286107122898102,
0.040631312876939774,
0.0067606838420033455,
0.02923371084034443,
0.08219736814498901,
-0.06972673535346985,
-0.054282885044813156,
0.01... |
ALDOB\n\tgene\tencoding\taldolase\tB\t(fructose-1,6-\nbiphosphate\taldolase)\timpairs\tthe\tcatalytic\tactivity\tof\tthe\tenzyme\tand\tprevents\tfructose\tfrom\tbeing\nconverted\tto\tglucose.\tBreast-fed\tinfants\tare\ttypically\tasymptomatic\tuntil\tfruit\tis\tadded\tto\n\tthe\tdiet.\nNutrition\ttherapy\tinvolves\tthe... | [
-0.006177246104925871,
-0.07979288697242737,
-0.008482170291244984,
0.04928971081972122,
-0.05565802380442619,
0.044924404472112656,
0.03646067529916763,
0.014549896121025085,
-0.037659093737602234,
0.026352940127253532,
0.06174694374203682,
-0.07876726239919662,
-0.027825165539979935,
-0.... |
disaccharide\tsucrose.\tIn\tthe\tabsence\tof\tunderstanding\tthe\tpresence\tof\tthis\tgenetic\tlesion\tand\tthe\nneed\tto\teliminate\tthese\tsweeteners\tfrom\tthe\tdiet,\tthe\tindividual\ttypically\tproceeds\tto\tdevelop\nhypoglycemia,\tvomiting,\tand\tultimately\tkidney\tfailure,\tleading\tto\tdeath.\nThese\tdisorders... | [
0.008410736918449402,
-0.07145936042070389,
0.06826478242874146,
0.021497348323464394,
-0.08659474551677704,
0.012401624582707882,
0.1330752819776535,
-0.001222524675540626,
-0.006109930574893951,
0.0805729553103447,
0.10620124638080597,
-0.021966423839330673,
0.022505713626742363,
-0.0214... |
These\tdisorders\thighlight\n\tthe\tpower\tof\tunderstanding\tthe\tunderlying\tgenetic\tmutation\twhen\ndeveloping\tnutrition\ttherapeutic\tapproaches.\tFirst,\tthe\tfamily\thistory\tmay\tgive\ta\thint\tthat\ta\tgenetic\nmutation\tis\tpresent.\tAlthough\tthe\tgenetic\tmutation\t(\ngenotype\n)\tis\tpermanent,\tthe\t\nph... | [
0.025556035339832306,
0.0076455543749034405,
0.08235499262809753,
0.004216357134282589,
-0.09747675061225891,
0.021712621673941612,
0.04868033155798912,
-0.012321178801357746,
-0.035845767706632614,
0.08609432727098465,
0.10568307340145111,
-0.03481808304786682,
-0.013937421143054962,
-0.0... |
genotype\n)\tis\tpermanent,\tthe\t\nphenotype\n\tis\tnot.\nIn\tspite\tof\tan\tindividual\thaving\tmutations\tthat\tpredispose\tto\tdisease,\teliminating\tspecific\tfoods\tand\nfood\tingredients\tessentially\tkeeps\n\tthe\tdisease\tsusceptibility\tsilent,\tand\tthe\tinfant\twill\tenjoy\tnormal\ndevelopment.\tNutrition\t... | [
0.026318272575736046,
-0.020605215802788734,
0.046969056129455566,
0.008577534928917885,
-0.05178101360797882,
0.0171196386218071,
0.07747923582792282,
-0.0035655165556818247,
-0.038882385939359665,
0.07820655405521393,
0.1584104299545288,
-0.06512058526277542,
-0.021100345999002457,
0.016... |
recommend\tthe\tappropriate\ttherapy\tsufficiently\tearly\tto\tprevent\tdisease\tsymptoms\tfrom\tmanifesting\nand\tcausing\tserious\tdevelopmental\tissues.\nThe\tX-linked\tdominant\tfragile\tX\tsyndrome\talso\taffects\tnutritional\tstatus.\tFragile\tX\tsyndrome\tis\ncharacterized\tby\tdevelopmental\tdelays,\tmental\tim... | [
0.008376226760447025,
-0.056151557713747025,
0.06976459920406342,
0.024494118988513947,
-0.07025790214538574,
-0.009440870955586433,
0.06169022247195244,
0.09008991718292236,
-0.07990693300962448,
0.044220566749572754,
0.12193010747432709,
0.02225014939904213,
-0.00286872498691082,
0.09493... |
occurs\twithin\tthe\t\nFMR1\n\tgene\ton\tthe\tX\tchromosome\tin\twhich\ta\tcytosine-guanine-guanine\ntrinucleotide\tsegment\tis\trepeated\tmore\ttimes\tthan\tthe\tusual\tnumber\tfor\thuman\tbeings.\tThe\tmultiple\nrepeats\tof\tthis\ttrinucleotide\tmake\tthe\tX\tchromosome\tsusceptible\tto\tbreakage.\tAnother\tX-linked\... | [
-0.06395604461431503,
-0.0701223686337471,
0.03003465197980404,
-0.04602149873971939,
-0.07300117611885071,
0.018557051196694374,
0.03869827464222908,
0.0394291952252388,
0.013519346714019775,
0.07964472472667694,
0.13682188093662262,
-0.02384210005402565,
-0.014716473408043385,
0.05962000... |
dominant\tdisorder\tis\ta\tform\n\tof\thypophosphatemic\trickets.\tThis\tdisorder\tis\tfound\tin\tmales\tand\nfemales,\tis\tresistant\tto\tvitamin\tD\ttherapy,\tand\tis\tcharacterized\tby\tbone\tanomalies,\twhich\tinclude\ndental\tmalformations\tand\tresultant\tfeeding\tchallenges.\nX-linked\trecessive\tconditions\tinc... | [
-0.00394586892798543,
-0.0607023648917675,
0.07044605910778046,
-0.03152795135974884,
-0.11774604767560959,
-0.008986384607851505,
0.06180901825428009,
0.017041875049471855,
-0.03026152029633522,
0.09745211154222488,
0.10245257616043091,
0.00862915813922882,
-0.001102407113648951,
0.040352... |
Duchenne\tmuscular\tdystrophy\t(DMD)\tdisorders.\tIndividuals\twith\tX-linked\trecessive\n\tnephrogenic\ndiabetes\tinsipidus\tare\tunable\tto\tconcentrate\turine\tand\texhibit\tpolyuria\tand\tpolydipsia.\tThis\tdisorder\nusually\tis\tdetected\tin\tinfancy\tand\tcan\tmanifest\tas\tdehydration,\tpoor\tfeeding,\tvomiting,... | [
-0.015262821689248085,
-0.041700538247823715,
0.06813424825668335,
0.007932428270578384,
-0.13547417521476746,
-0.01705045998096466,
0.11274293065071106,
0.03336615860462189,
-0.009191756136715412,
0.045750197023153305,
0.08076151460409164,
-0.040254659950733185,
-0.010738939978182316,
0.0... |
thrive.\tX-linked\trecessive\tadrenoleukodystrophy\tresults\tfrom\ta\tdefect\tin\tthe\tenzyme\tthat\tdegrades\nlong-chain\tfatty\tacids.\tThese\tfats\taccumulate\tand\tlead\tto\tbrain\tand\tadrenal\tdysfunction\n\tand\nultimately\tmotor\tdysfunction.\tX-linked\trecessive\tDMD\tis\tcharacterized\tby\tfatty\tinfiltration... | [
-0.02086333930492401,
-0.12778422236442566,
0.07400035858154297,
0.011072413064539433,
-0.146900936961174,
-0.03483313322067261,
0.06761482357978821,
0.08924876153469086,
-0.048546116799116135,
-0.012035663239657879,
0.09313921630382538,
-0.005847715772688389,
0.005403148476034403,
0.03935... |
and\textreme\tmuscle\twasting.\tChildren\ttypically\tare\tconfined\tto\ta\twheelchair\tby\tthe\ttime\tthey\treach\ntheir\tteens\tand\tneed\tassistance\twith\tfeeding.\nY-linked\tinheritance\tdisorders\tprimarily\tinvolve\tmale\tsex\tdetermination.\tAt\tthis\ttime\tno\tnutrition-\nrelated\tdisorders\thave\tbeen\tassigne... | [
0.018061691895127296,
-0.06538296490907669,
0.0736764445900917,
-0.03765767067670822,
-0.11043930798768997,
-0.002789274789392948,
0.05609850957989693,
0.01038755476474762,
0.04956800118088722,
0.05749325081706047,
0.11460105329751968,
-0.01455613225698471,
0.04913735389709473,
0.025725446... |
to\tthe\tY\tchromosome.\nIn\tsummary,\tany\tgene\tpotentially\tcan\tundergo\tmutation,\twhich\tcan\taffect\tthe\tfunction\tof\tits\nprotein\tand\tthe\thealth\tof\tthe\tindividual.\tIts\tlocation\twithin\tthe\tnuclear\tDNA\tor\tmtDNA\tdetermines\tits\nmode\tof\tinheritance.\tSee\t\nChapter\t42\n\tfor\tmore\tinformation\... | [
-0.00716835493221879,
-0.06728003919124603,
0.04963347688317299,
-0.02624637261033058,
-0.11243423819541931,
-0.004825920797884464,
0.07926813513040543,
-0.03445048630237579,
0.000799678557086736,
0.08184272050857544,
0.12732838094234467,
-0.034661319106817245,
0.018774015828967094,
0.0521... |
Disease\tat\tthe\tepigenetic\tlevel\nAlthough\tepigenetic\tmechanisms\tare\tmajor\tcontributors\n\tto\tchronic\tdisease\tthrough\tthe\tgene-\nenvironment\tinteractions,\tmuch\tremains\tto\tbe\tdiscovered\tregarding\tthe\tusual\tepigenomic\tpatterns\nof\teach\tgene\tinvolved\tand\tthe\tmechanisms\tby\twhich\tthat\tpatte... | [
0.028395751491189003,
-0.023053035140037537,
0.09085959196090698,
-0.005476329475641251,
-0.09040241688489914,
-0.01301026064902544,
0.047585152089595795,
0.0009495166596025229,
-0.05348750203847885,
0.11110930889844894,
0.09567961096763611,
-0.08915889263153076,
0.012986427173018456,
0.03... |
environmental\ttriggers.\tDetails\tmust\tawait\tthe\toutcomes\tof\tthe\tmany\tstudies\tcurrently\tunderway.\nInstead,\tlet’s\ttake\ta\tmoment\tto\tacknowledge\tthe\tvaluable\tcontributions\tof\tnutrition\n\tpioneers\twho\nalerted\tthe\tfield\tto\tthe\timportance\tof\tnutrition-related\tepigenetics\tto\thealth.\tOrnish\... | [
0.028239596635103226,
-0.0428709015250206,
0.07324537634849548,
-0.0032855479512363672,
-0.08628925681114197,
-0.0026100403629243374,
0.05593749135732651,
-0.03250626474618912,
0.01043766364455223,
0.08312258124351501,
0.08709951490163803,
-0.033861901611089706,
0.035750098526477814,
-0.00... |
the\tpower\tof\tnutrition\tand\tlifestyle\ttherapy\tto\tchange\tcardiovascular\tdisease\tand\tprostate\tcancer\noutcomes\tand\tlinked\tthe\tlatter\twork\tto\tregulation\tof\tprostate\tgene\texpression\t(\nOrnish\tet\tal,\t2008\n).\nKallio\tet\tal\t(2007)\n\tdemonstrated\tthat\tchanging\tthe\tcarbohydrate\tcomposition\t... | [
-0.03427552431821823,
-0.01412151101976633,
0.07743892818689346,
-0.0011320863850414753,
-0.08608746528625488,
0.04554632678627968,
0.06747697293758392,
0.020346583798527718,
0.032860368490219116,
0.04993128031492233,
0.0739605650305748,
-0.032472316175699234,
0.04067755863070488,
0.009130... |
affects\tgene\nexpression,\twhich\tincludes\tgenes\tthat\tregulate\tinsulin\tsignaling.\tStover\thas\tlong\tstudied\tthe\tbasis\nfor\tindividual\tdifferences\tin\tdiet-related\tdisease\tfrom\tan\tepigenetic\tstandpoint\tand\tsounded\tan\tearly\nalarm\ton\tthe\tneed\tto\tuse\tcare\tin\tthe\tconcentration\tof\tfolate\tus... | [
0.02499530464410782,
-0.012095380574464798,
0.10807177424430847,
0.005075528752058744,
-0.05682416260242462,
0.02454543672502041,
0.09293374419212341,
0.02945059910416603,
-0.0382842980325222,
0.05506467819213867,
0.09154370427131653,
-0.038617320358753204,
0.03612381964921951,
0.018903335... |
supplements,\tand\tmedication\tbecause\tof\tfolate’s\trole\tas\tthe\tprimary\tsource\tof\tmethyl\n\tgroups\tused\tto\nsilence\tgene\texpression\t(\nStover\tet\tal,\t2018\n).\tTheir\tinsight\thas\tcontributed\tsubstantially\tto\tthe\nunderstanding\tthat\tnutrition\tis\tcritically\timportant\tat\tthe\tmolecular\tlevel\ta... | [
0.030238019302487373,
-0.08214613050222397,
0.024160316213965416,
-0.013075863011181355,
-0.074166439473629,
0.010073846206068993,
0.05643029510974884,
0.06758032739162445,
0.00928443018347025,
0.03006063774228096,
0.09431192278862,
-0.023661980405449867,
0.03141355887055397,
0.03206948935... |
metabolic,\tand\tphysiologic\tlevels.\nNutritional\tgenomics\tand\tchronic\tdisease\nHealth\tcare\tproviders\tare\tgradually\tincorporating\tthe\tvarious\t“omic”\tdisciplines\tinto\tassessment,\ndiagnosis,\n\tintervention,\tand\tmonitoring/evaluation.\tTo\tdo\tso\trequires\ta\tdeep\tfoundation\tof | [
-0.006973042152822018,
-0.019732851535081863,
0.008699094876646996,
0.010311738587915897,
-0.05302261933684349,
-0.0022811233066022396,
0.07429817318916321,
0.04198465868830681,
-0.04828598350286484,
0.03392726555466652,
0.036057714372873306,
-0.052131444215774536,
-0.07408756762742996,
0.... |
knowledge\tthat\tconnects\tgenetic\tand\tepigenetic\tsignatures\tto\tparticular\tdisease\tstates\tso\tthat\tan\nappropriate\ttarget\tfor\ttherapy\tis\tidentified.\tAdditionally,\tassessment\tand\tdiagnosis\tmust\tbe\tfollowed\nby\tinterventions\tknown\tto\trestore\thealth\tto\tthose\twith\texisting\tdisease\tor\tto\tpr... | [
0.018623020499944687,
0.0019174469634890556,
0.07266431301832199,
-0.0011759338667616248,
-0.0692179799079895,
0.0012663246598094702,
0.10700133442878723,
-0.031135430559515953,
-0.048247382044792175,
0.08168631047010422,
0.12304693460464478,
-0.03773680329322815,
0.0468083918094635,
0.014... |
in\tthose\n\tsusceptible\twho\tdo\tnot\tyet\tmanifest\tsymptoms.\tThis\toverall\tapproach\tis\twell\tunderway\tfor\nthe\tsingle\tgene\tdisorders\tfor\twhich\tgene\tvariants\thave\tbeen\tidentified\tand\tconnected\tto\tthe\nbiochemical\tand\tphysiologic\tconsequences,\tand\tfor\twhich\teffective\tinterventions\thave\tbe... | [
0.05988107994198799,
-0.05639803782105446,
0.07043576240539551,
-0.020944159477949142,
-0.08282264322042465,
0.004067054018378258,
0.0885675773024559,
-0.01675008423626423,
0.03225081041455269,
0.07783868163824081,
0.06936202943325043,
-0.04690290614962578,
0.034283481538295746,
0.03305726... |
developed,\ttested,\tand\tapplied.\nIn\tcontrast,\tthe\tmajority\tof\tclinic\tvisits\tare\tfor\tpatients\twith\tone\tor\tmore\tcomplex\tchronic\n\tdiseases.\nRestoring\thealth\tor\tpreventing\tdisease\tin\tthe\tcase\tof\tchronic\tdisorders\tis\tan\tambitious\tundertaking\nthat\twill\tlikely\trequire\tdecades\tof\tbasic... | [
-0.013796386308968067,
-0.030230196192860603,
0.0782378762960434,
-0.028714675456285477,
-0.14282457530498505,
0.016884544864296913,
0.08709458261728287,
0.024495551362633705,
0.008714739233255386,
0.046491075307130814,
0.07610972225666046,
0.006068110931664705,
0.04046018421649933,
0.0403... |
Even\twhen\tthere\tare\tnot\tyet\twell-defined\tnutritional\tgenomics\tprotocols\tfor\tparticular\tdisorders,\ndiet-and-lifestyle\ttherapy\tcan\toften\tbe\thelpful.\nOf\tparticular\tinterest\tto\tnutrition\n\tprofessionals\tis\tthe\temerging\tdiscipline\tof\tnutritional\tgenomics\nand\tits\trole\tin\tprecision/personal... | [
-0.002419760450720787,
0.027983853593468666,
0.023772206157445908,
0.03799305483698845,
0.006493496708571911,
-0.012498348020017147,
0.03869136422872543,
0.04356297850608826,
-0.07149138301610947,
0.02402612753212452,
0.06607573479413986,
0.0051035466603934765,
-0.03125341981649399,
-0.005... |
Nutritional\tgenomics\n\tis\ta\tfield\tof\tstudy\tfocused\ton\nthe\tinteraction\tbetween\tgenes,\tdiet,\tlifestyle\tfactors,\tand\thuman\thealth.\tIncluded\twithin\tnutritional\ngenomics\tare\t\nnutrigenetics\n,\n\t\nnutrigenomics\n,\tand\tnutrition-related\taspects\tof\t\nepigenetics\n\tand\nepigenomics\n,\twhich\tpro... | [
-0.029494408518075943,
-0.02713942714035511,
0.027132853865623474,
0.03150291368365288,
0.004255698528140783,
0.054771147668361664,
0.06560822576284409,
0.03240494057536125,
-0.07469729334115982,
0.02503403276205063,
0.0792594850063324,
-0.05588624253869057,
-0.0482400581240654,
-0.0212396... |
into\thow\tenvironmental\tfactors\tregulate\tgene\texpression.\nNutritional\tgenomics\tand\tits\tsubdisciplines\tencompass\tnumerous\tother\tdisciplines:\tmolecular\nbiology,\tbiochemistry,\tintermediary\tmetabolism,\ttranscriptomics,\tproteomics,\tmetabolomics,\tthe\nmicrobiome,\tneuroscience,\tand\tbehavioral\tchange... | [
0.020455706864595413,
-0.07060703635215759,
-0.01102683786302805,
-0.022266101092100143,
-0.04571865499019623,
-0.0019823010079562664,
0.026777038350701332,
0.04182089865207672,
-0.022077487781643867,
0.062073469161987305,
0.03157403692603111,
-0.060417961329221725,
-0.02476101741194725,
0... |
review\ton\tnutritional\tgenomics\tfor\tan\toverview\tof\tcurrent\tprogress\n\tin\tthe\tfield\t(\nRozga\tand\tHandu,\n2018\n).\tAs\tthese\tdisciplines\tevolve,\tpractitioners\twill\tincreasingly\tbe\table\tto\ttailor\tdiet\tand\tlifestyle\nchoices\tto\tthe\tgenetic\tmakeup\tof\teach\tclient.\nNutrigenetics\tconcerns\tt... | [
-0.015016000717878342,
-0.006780714262276888,
0.04342637583613396,
0.03158646449446678,
-0.07189067453145981,
0.018051302060484886,
0.07289288192987442,
-0.008164850994944572,
-0.02570265159010887,
0.05044122412800789,
0.08817951381206512,
-0.03524211049079895,
-0.0069153886288404465,
0.02... |
dietary\tinput.\tFor\texample,\tan\toften-cited\tillustration\tof\tnutrigenetics\tinvolves\ta\tvariant\tin\tthe\t5,10-\nmethylenetetrahydrofolate\n\treductase\t(\nMTHFR\n)\tgene.\tMutations\tin\tthis\tgene\tcan\tresult\tin\ta\nsubstantial\tdecrease\tin\tenzyme\tactivity\twhich\tis\tresponsible\tfor\tconverting\tdietary... | [
-0.018755091354250908,
-0.02562106028199196,
0.061202775686979294,
-0.0002811511803884059,
-0.06852784007787704,
0.005930737592279911,
0.07906429469585419,
-0.011787143535912037,
-0.05577635020017624,
0.03171124681830406,
0.11197112500667572,
-0.07598689943552017,
-0.01836191676557064,
-0.... |
into\t5-methyl\tfolate,\tthe\tactive\tform.\tIndividuals\twith\tsuch\ta\tmutation\twould\tneed\tadditional\tfolate\tin\nthe\tdiet\tfor\toptimal\thealth.\nNutritional\tgenomics\tis\tbeing\tadvanced\tfor\tclinical\tapplications\tto\tcommon\tchronic\tdisorders\tsuch\nas\tcancer,\ttype\t2\tdiabetes,\tobesity,\tand\tvascula... | [
-0.027692241594195366,
-0.05551036074757576,
0.015671666711568832,
-0.040178313851356506,
-0.08336053043603897,
-0.0320109948515892,
0.03724093362689018,
0.05250900983810425,
-0.027302179485559464,
0.04702971503138542,
0.07250555604696274,
-0.05468560755252838,
0.006548387464135885,
0.0475... |
such\tas\tinflammation\tand\tbiotransformation.\tAt\tthis\ttime\thuman\tclinical\tstudies\tare\tlimited,\tand\tthe | [
-0.011863616295158863,
0.014219418168067932,
0.06550230830907822,
-0.030673453584313393,
-0.057145729660987854,
0.017927270382642746,
0.10920754075050354,
-0.004867598880082369,
0.04776589944958687,
0.0019954880699515343,
0.0646522119641304,
-0.05143070966005325,
-0.036348916590213776,
0.0... |
field\tis\tfocused\ton\tdeveloping\tthe\tresearch\tfoundation\tto\tbe\table\tto\tmake\tthe\tconnections\tamong\ngene\tvariants,\tdisease,\tfunctional\timpact,\tand\teffective\tinterventions.\tEarly\tadopters\tare\tdeveloping\nnutrigenetic\ttest\tpanels\tintended\tto\tguide\tpractitioners\tand\ttheir\tclients\tin\tident... | [
0.03247153013944626,
-0.04833489656448364,
0.08625292032957077,
-0.017800919711589813,
-0.09977609664201736,
-0.004665920976549387,
0.10416297614574432,
0.015056733042001724,
0.013281365856528282,
0.05682583525776863,
0.06404362618923187,
-0.05238964036107063,
0.029602445662021637,
0.00783... |
susceptibilities\tand\toffering\trecommendations\tfor\thealth\tpromotion.\tClients\tare\tbringing\ttheir\ttest\nresults\tto\tnutrition\tprofessionals\tfor\thelp\twith\timplementing\tthese\trecommendations.\tWhere\tthere\nare\tvariants\tcommon\tacross\tnutrigenetic\tpanels,\tthese\twill\tbe\tbriefly\tdiscussed\tin\torde... | [
0.030508626252412796,
-0.057908978313207626,
0.06288400292396545,
-0.037428174167871475,
-0.12383120507001877,
-0.002454527420923114,
0.13278743624687195,
-0.006411671172827482,
0.0003712412144523114,
0.04596824571490288,
0.10168664902448654,
-0.05454140529036522,
0.05881858989596367,
0.02... |
readers\taware\n\tof\twhat\tthey\tmay\tencounter\tin\tpractice.\tExpect\tconsiderably\tmore\tvariants\tto\tbe\nidentified\tand\tincreasingly\ttargeted\tinterventions\tto\tbe\tdeveloped\tin\tthe\tyears\tahead.\nGenetic\ttesting\tand\tnutrition\tcare\tprocess\nThe\tlong-term\tpromise\tof\tnutritional\tgenomics\tis\tthe\t... | [
0.021766558289527893,
-0.054129380732774734,
0.06807521730661392,
-0.016258997842669487,
-0.0745299905538559,
-0.0021960162557661533,
0.10012950003147125,
0.01836748793721199,
-0.0070260148495435715,
0.06821092218160629,
0.10182414203882217,
-0.028917906805872917,
0.020878823474049568,
0.0... |
translate\tthis\tinformation\tinto\tdiet-and-lifestyle\tapproaches\tpersonalized\tto\tthe\tindividual.\n\tIn\tthe\nshorter\tterm,\tthe\texpectation\tis\tthat\tthe\tinformation\tcan\tbe\tused\tto\tmove\taway\tfrom\tone-size-fits-all\nto\tidentifying\tcategories\tof\tindividuals\twith\tchronic\tdisease\twho\twould\tbenef... | [
0.007884206250309944,
-0.019381025806069374,
0.061027299612760544,
-0.0545060932636261,
-0.14538632333278656,
-0.03439822420477867,
0.08530429750680923,
0.007974806241691113,
-0.004853079095482826,
0.008299704641103745,
0.09928655624389648,
-0.0806678831577301,
0.04398974031209946,
0.02316... |
therapeutic\tapproach\tbased\ton\ttheir\tgenetic\tmakeup\tand\tmodified\tfor\ttheir\tspecific\tenvironmental\nchallenges.\tGenomics\twill\tbe\tfundamental\tin\tthis\teffort\tsince\tgene\tvariants\twill\tbe\tthe\n\tbasis\tfor\nidentifying\tsusceptibility.\tEpigenetics\twill\tbe\tsimilarly\timportant\tbecause\tit\tis\tth... | [
0.008048425428569317,
-0.0645064264535904,
0.05754398554563522,
-0.02308410406112671,
-0.09387768059968948,
-0.014094559475779533,
0.09591341018676758,
0.02523360773921013,
0.025777192786335945,
0.05495930463075638,
0.08520033210515976,
-0.04083644226193428,
0.03356591612100601,
0.03929251... |
expression\tpatterns\tin\tresponse\tto\tlifestyle\tchoices.\nThe\tfirst\tstep\tin\tnutrigenetic\ttesting\tis\tassessment.\tGenome\tsequencing\tis\tused\tto\tquery\tthe\nclient’s\tgenome\tto\tidentify\tgenetic\tvariants\tpresent.\tEpigenomics\twill\tpotentially\tbe\tadded\tin\tthe\nnot-too-distant\tfuture\tto\tidentify\... | [
-0.008150693029165268,
-0.022811081260442734,
0.06962977349758148,
-0.031818658113479614,
-0.09574373811483383,
0.019540131092071533,
0.01648271642625332,
-0.004806934390217066,
0.00693853385746479,
0.06689946353435516,
0.08389989286661148,
-0.08348681032657623,
-0.006497874855995178,
0.02... |
signatures\tand\ttheir\tinfluence\ton\tgene\texpression.\nGenomic\tanalysis\tis\taccomplished\teither\tby\tgenetic\ttechnology\tthat\tdetects\tspecific\tvariants\n(typically\treferred\tto\tas\tmicroarray\tchips),\tthrough\tsequencing\tof\tthe\tgene-related\tparts\tof\tthe\ngenome\t(whole\texome\tsequencing),\tor\tthrou... | [
0.02232339419424534,
-0.025826267898082733,
0.037780363112688065,
-0.07156067341566086,
-0.07253590226173401,
-0.035607945173978806,
0.05242093279957771,
-0.010239627212285995,
-0.005283995531499386,
0.0027426090091466904,
0.05806061252951622,
-0.019670959562063217,
0.06949487328529358,
-0... |
sequencing\ttechnology\tto\tthe\tpresent\tnext-generation\tsequencing\n\thas\tgreatly\tdecreased\tthe\tcost\nand\tthe\ttime\tneeded\tfor\tsequencing\tand\tis\trapidly\tbecoming\tthe\tpreferred\ttechnology\tfor\tchronic\ndisease\tresearch.\tOnce\tthe\tsequence\tis\tobtained,\tthere\tare\tnumerous\tcomputer\talgorithms\t... | [
-0.011722900904715061,
-0.03496936708688736,
0.032375968992710114,
-0.08392898738384247,
-0.08454319834709167,
0.009694543667137623,
0.014547538012266159,
-0.013814574107527733,
0.006699392572045326,
0.07430711388587952,
0.07579132914543152,
-0.026222243905067444,
0.04939534142613411,
0.01... |
detect\tparticular\tgene\tvariants\tof\tinterest.\tSome\tfilters\tare\treadily\tavailable;\tothers\tare\tproprietary\nto\tcompanies\tin\tthe\tbusiness\tof\tconverting\tthe\tpresence\tof\tgene\tvariants\n\tinto\trecommendations\tfor\nimproving\thealth\tand\tdecreasing\tdisease\tsusceptibility. | [
0.03480573743581772,
-0.058763690292835236,
0.06457114964723587,
-0.043886665254831314,
-0.022901277989149094,
0.007508847862482071,
0.11429500579833984,
-0.049010343849658966,
-0.03823847323656082,
0.0351424515247345,
0.06288689374923706,
-0.10009273141622543,
0.03998136520385742,
0.08657... |
improving\thealth\tand\tdecreasing\tdisease\tsusceptibility.\nThe\tfollowing\tpoints\tshould\tbe\tconsidered\tbefore\ttaking\ta\tnutrigenetic\ttest\tor\twhen\tassisting\tyour\nclients\tin\tunderstanding\tthe\ttest\tresults\tthat\tthey\tor\ttheir\tproviders\thave\tordered.\n•\t\nEvaluate\tthe\tcredentials\tof\tthe\tcomp... | [
0.015639903023838997,
-0.03443598002195358,
0.08463754504919052,
-0.047705791890621185,
-0.08433880656957626,
-0.04055619612336159,
0.02431359700858593,
0.017801178619265556,
-0.06993261724710464,
0.04388147592544556,
0.06895837932825089,
0.03917485848069191,
0.03898291662335396,
0.0306136... |
being\tconducted\tin\tan\tappropriately\n\tcredentialed\tlaboratory\t(at\tleast\tCLIA-certified)?\n•\t\nHow\twill\tthe\tclient’s\tprivacy\tbe\tprotected?\n•\t\nWhat\tis\tthe\tcost\tof\tthe\ttest?\n•\t\nTo\twhom\twill\tthe\ttest\tresults\tbe\tsent?\n•\t\nHow\tlong\tbefore\tthe\tresults\twill\tbe\tavailable?\n• | [
0.04367563873529434,
-0.011165224015712738,
0.0660109743475914,
-0.0034499831963330507,
-0.09042457491159439,
0.0030583376064896584,
0.12646785378456116,
0.020838549360632896,
-0.01613706722855568,
0.034633178263902664,
0.07147666811943054,
-0.04932032898068428,
0.025394141674041748,
0.044... |
•\t\nHow\tlong\tbefore\tthe\tresults\twill\tbe\tavailable?\n•\t\nIs\tthe\tDNA\tsample\tdestroyed\tfollowing\tanalysis?\tIf\tsaved,\thow\twill\tit\tbe\tused\tin\tthe\tfuture?\nThe\tconsumer\twill\tneed\tto\tprovide\twritten\tconsent\tto\thave\ttheir\tsample\tretained\n\tand\tused\nfor\tfuture\tanalyses.\n•\t\nWhat\twill... | [
0.027847783640027046,
-0.03740387782454491,
0.06789795309305191,
-0.0709923654794693,
-0.09973712265491486,
0.017999162897467613,
0.0751420110464096,
-0.0009947505313903093,
0.022044621407985687,
0.05734417587518692,
0.0666029304265976,
-0.004105052910745144,
0.04201037436723709,
0.0124964... |
•\t\nWhat\twill\tbe\tincluded\tin\tthe\treport\tof\tthe\ttest\tresults?\n•\t\nWhich\tvariants\twill\tbe\texamined\tand\tare\trs\tnumbers\treported\talong\twith\tthe\tSNP?\n•\t\nWhat\tis\tthe\tassociation\tof\teach\tvariant\twith\ta\tdisease?\tDoes\tthe\tcompany\tmake\tthe\tstudies\navailable\tthat\tlink\tthe\tvariants\... | [
0.050527215003967285,
-0.07358473539352417,
0.07195369899272919,
-0.05694444105029106,
-0.1015491858124733,
0.006731275003403425,
0.08574453741312027,
-0.012836656533181667,
0.01111844927072525,
0.09072443097829819,
0.10308914631605148,
-0.0011830360163003206,
0.004117636941373348,
0.02772... |
available\tthat\tlink\tthe\tvariants\t(SNPs)\twith\tdiseases?\n•\t\nWhich\tlifestyle\tchoices\tare\tparticularly\timportant\tin\tpromoting\tdisease\n\twhen\tthis\tvariant\tis\npresent?\nSeveral\tprominent\tnutritional\tgenomics\tresearchers\thave\tproposed\tguidelines\tfor\tevaluating\tthe\nvalidity\tof\tnutrigenetic\t... | [
-0.013172218576073647,
-0.07709198445081711,
0.0234102513641119,
-0.03160649910569191,
-0.03685426339507103,
0.036588896065950394,
0.030330492183566093,
0.04066082462668419,
-0.03727824613451958,
0.017126448452472687,
0.10554850846529007,
-0.022764815017580986,
-0.011957263574004173,
0.019... |
Grimaldi\tet\tal,\t2017\n).\tAdditionally,\tthe\nAcademy\tof\tNutrition\tand\tDietetics’\t2014\tnutritional\tgenomics\tposition\tpaper\tdescribes\tthe\tvarious\ngovernmental\tagencies\tthat\thave\tat\tleast\tsome\toversight\tof\tnutritional\n\tgenomics,\tparticularly\tdirect-\nto-consumer\ttesting\t(\nCamp\tand\tTrujil... | [
-0.02445712685585022,
-0.03447186201810837,
0.07309437543153763,
-0.06804298609495163,
-0.05589766427874565,
0.033574268221855164,
0.03464636951684952,
0.034655965864658356,
-0.04690836742520332,
0.002224117983132601,
0.11229946464300156,
-0.05528800189495087,
-0.004063066095113754,
0.0048... |
to-consumer\ttesting\t(\nCamp\tand\tTrujillo,\t2014\n).\nThe\tinformation\tthat\tis\tgenerated\tby\tgenetic\ttests\tcan\tprovide\tinsight\tinto\tan\tindividual’s\tpresent\nhealth\tstatus\tand\tfuture\tdisease\tsusceptibilities\tto\ta\tmuch\tgreater\tdegree\tthan\thas\tbeen\tpossible\tto | [
0.002588841365650296,
-0.0386841781437397,
0.02063853293657303,
-0.01783481426537037,
-0.05989312380552292,
0.007954210974276066,
0.14114318788051605,
0.0049720145761966705,
-0.011003506369888783,
0.03201732411980629,
0.14512287080287933,
-0.05813851207494736,
0.02569694072008133,
0.027516... |
date.\tClients\twill\twant\tto\tknow\tthat\ttheir\tinformation\twill\tbe\theld\tprivate\tlike\tany\tother\thealth\tcare\ndata\tand\tthat\n\tit\tcannot\tbe\tused\tto\tdiscriminate\tagainst\tthem\tin\tobtaining\temployment\tor\tinsurance.\nUnintended\tconsequences\tof\tgenetic\ttesting\tare\toften\tcauses\tof\tconcern\tf... | [
-0.027152523398399353,
0.015939492732286453,
0.05370629206299782,
-0.038390256464481354,
-0.092585988342762,
0.010521704331040382,
0.10688278079032898,
-0.020774779841303825,
0.027762427926063538,
0.04774890094995499,
0.09848461300134659,
-0.028962677344679832,
0.047579288482666016,
-0.015... |
in\tgenetic\ttesting\tacross\thealth\tcare\tmakes\tunderstanding\tthose\tconsequences\tespecially\timportant\nfor\tnutrition\tprofessionals.\tSee\t\nBox\t6.13\n\tfor\tmore\ton\tthis\ttopic.\nBOX\t6.13\nELSI:\tEthical,\tLegal,\tand\tSocial\tImplications\n\t\nof\tGenomics\nFor\tthe\tvarious\t“omic”\ttechnologies\tto\tbe\... | [
-0.009757705964148045,
0.01271918136626482,
0.024969011545181274,
-0.07338637113571167,
-0.11799141019582748,
-0.003911539446562529,
0.07070591300725937,
-0.0052852691151201725,
0.017632346600294113,
0.007049880921840668,
0.10025522112846375,
-0.028555192053318024,
0.03585786744952202,
0.0... |
their\tuse.\tOf\tparticular\tconcern\tto\tclients\thas\tbeen\twhether\tgenetic\tinformation\tin\tthe\thands\tof\ninsurers\tor\temployers\tcould\tlead\tto\tdiscrimination\tagainst\tapplicants.\tThese\tand\tother\tissues\tare\nthe\tsubject\tof\tdebate\tand\tresearch\tinto\tthe\tethical,\tlegal,\tand\tsocial\timplications... | [
0.01693618856370449,
-0.019522741436958313,
0.053277455270290375,
-0.0550251379609108,
-0.13411062955856323,
-0.02753807231783867,
0.07612169533967972,
-0.03128146752715111,
0.017796866595745087,
0.10689669102430344,
0.12072154879570007,
-0.03653961792588234,
0.015015200711786747,
0.022030... |
of\tgenetic\nresearch\tand\ttechnologies.\nFrom\tthe\tbeginning\tof\tthe\tHuman\tGenome\tProject,\tscientists,\tpolicymakers,\tand\tthe\tpublic\nhave\tworked\tto\taddress\t\nELSI\n\tissues\tin\tgenetic\tresearch\tand\ttechnologies\tto\tinform\tand\tprotect\nthe\tpublic.\tSome\tof\tthe\tpotential\tharms\thave\tbeen\tadd... | [
0.020414751023054123,
-0.0019205061253160238,
0.08574678748846054,
-0.03691328316926956,
-0.11372154206037521,
0.0031295872759073973,
0.06160091981291771,
0.01706003211438656,
-0.01318324450403452,
0.07889368385076523,
0.11711020767688751,
-0.04009430110454559,
-0.017012091353535652,
0.034... |
information\tis\tdefined\tas\tProtected\tHealth\tInformation\tby\tthe\tpassage\tof\tthe\tHealth\n\tInsurance | [
0.032412007451057434,
0.025424925610423088,
-0.04996247962117195,
-0.008399470709264278,
-0.04476045444607735,
0.006728866137564182,
0.13045057654380798,
0.008975327014923096,
0.03785763680934906,
0.05123032256960869,
0.09741242974996567,
-0.01823299005627632,
0.0264317337423563,
0.0443207... |
Portability\tand\tAccountability\tAct\t(HIPAA).\tThe\tpassage\tof\tthe\t\nGenetic\tInformation\nNondiscrimination\tAct\t(GINA)\n\tin\t2008\tis\tanother\timportant\tmilestone\tin\tensuring\tthat\tgenetic\ninformation\twill\tnot\tbe\tused\tto\tdiscriminate\tagainst\tAmericans\twith\trespect\tto\temployment\tor | [
-0.0012255326146259904,
-0.03033410757780075,
0.02480190247297287,
-0.029335370287299156,
-0.10658891499042511,
0.014810843393206596,
0.09410088509321213,
-0.024089276790618896,
-0.007588956970721483,
0.04341963678598404,
0.10222436487674713,
-0.009873991832137108,
-0.001805480569601059,
0... |
health\tinsurance.\tThis\tlegislation\tspecifically\tprohibits\tthe\tuse\tof\tgenetic\tinformation\tby\thealth\ninsurers\tto\tdeny\thealthy\n\tindividuals\tcoverage\tor\tto\tcharge\thigher\tthan\tusual\tpremiums\tbecause\nthat\tindividual\tmay\tdevelop\ta\tdisease\tin\tthe\tfuture.\tIt\talso\tbars\temployers\tfrom\tmak... | [
0.01711931638419628,
-0.014935242012143135,
0.08237913250923157,
-0.009485796093940735,
-0.11746127903461456,
0.00680290162563324,
0.1109016016125679,
0.015450255014002323,
-0.038755036890506744,
0.05780954286456108,
0.10253386199474335,
-0.07506315410137177,
0.021496977657079697,
-0.02733... |
firing,\tpromotion,\tor\tjob\tplacement\tdecisions\tbased\ton\tgenetic\tinformation.\nHowever,\tas\tthe\tpopularity\tof\tdirect-to-consumer\tgenetic\ttesting\thas\tincreased,\tthe\tissue\tof\nprivacy\tand\tnondiscrimination\tcontinues\tto\tbe\tof\tconcern\tto\tconsumers\n\tand\tto\tvarious\ngovernmental\tagencies.\tThe... | [
0.027300160378217697,
-0.04831179603934288,
0.05832116678357124,
-0.06654945760965347,
-0.06974580883979797,
0.0058950986713171005,
0.0897897258400917,
-0.01237383671104908,
-0.009357186034321785,
0.08302625268697739,
0.12302796542644501,
-0.0012361265253275633,
0.05532364547252655,
0.0269... |
companies\tsupplying\tthese\ttests\tprotect\tthe\tconsumer’s\tprivacy.\tThe\tnutrition\tprofessional\tshould\nbe\taware\tof\tthis\tconcern\tand\tbe\tready\tto\teducate\tclients\twho\tare\tconsidering\tgenetic\ttesting.\nResearch\tinto\tELSI\ttopics\tis\tongoing\tand\tis\temerging\tas\ta\tresearch\tfield\tin\tits\town\t... | [
0.014853270724415779,
-0.05359213799238205,
0.04108786582946777,
-0.06368689984083176,
-0.0937027633190155,
-0.0036193609703332186,
0.1054653748869896,
-0.03276386857032776,
0.0013232710771262646,
0.0012674942845478654,
0.0957314521074295,
0.00998988188803196,
0.021297920495271683,
0.01895... |
National\n\tHuman\tGenome\tResearch\tInstitute’s\tELSI\tresearch\tprogram,\testablished\tin\t1990,\ncontinues\tto\tconduct\tresearch\tinto\tELSI\tissues.\tA\tlist\tof\tthe\ttypes\tof\tresearch\tbeing\tconducted\ncan\tbe\tfound\ton\tthe\tNational\tHuman\tGenome\tResearch\tInstitute\twebsite\tunder\tELSI.\tThe | [
-0.00383058306761086,
-0.02155403234064579,
0.04070732370018959,
-0.06776750832796097,
-0.09516504406929016,
-0.02185557782649994,
0.05307711660861969,
-0.017550555989146233,
-0.04055332764983177,
0.09554821252822876,
0.11182606965303421,
-0.05436136946082115,
0.00795025285333395,
-0.02407... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.