0 stringlengths 12 494 | embeddings listlengths 384 384 |
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variants\tthat\toccur\tfrequently\tin\tseveral\tpopulations,\texpect\tthe\tresearch\tto\tbe\tongoing.\nAdditionally,\tthe\tvariants\twill\tneed\tto\tbe\tstrongly\tassociated\twith\tparticular\tenvironmental\ntriggers.\tObesogenic\tenvironments\tare\thighly\tvariable\tamong\tindividuals\teven\twithin\n\tthe\tsame | [
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the\tsame\npopulation,\twhich\tfurther\tcompounds\tthe\tamount\tof\twork\tahead\tto\tclearly\tlink\tvariants\twith\neffective\tclinical\tinterventions.\nEpigenetics\tand\tobesity\nBeyond\tthe\tmethylation,\tacetylation,\tand\tmiRNA\tstudies\tbeing\tconducted\twith\tthe\tvarious\tgene\nvariants,\tenvironmental\ttriggers... | [
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insight\tinto\thow\tthese\ttriggers\tpromote\tthe\n\ttransformation\tof\tobesity\tsusceptibility\tinto\tovert\ndisease.\tToday’s\tenvironment\tis\tfrequently\treferred\tto\tas\tobesogenic.\tTwo\taspects\tof\tthe\nenvironment\tthat\tare\tunder\tstudy\tare\tenvironmental\tpollutants\tand\ttheir\trole\tin\tpromoting\tobes... | [
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and\tthe\tcomposition\tof\tthe\tgut\tmicrobiota.\tThe\tterm\t“\nobesogen\n”\trefers\tto\tenvironmental\tpollutants\nthat\tpromote\tobesity\tbut\tthe\tterm\thas\texpanded\tover\ttime\tas\n\tit\thas\tbecome\tapparent\tthat\ta\twide\nvariety\tof\tpollutants\tlead\tto\toxidative\tstress\tand\tinflammation,\twhich\tpromote\... | [
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diabetes,\tvascular\tdisease,\tcancer,\tand\tvarious\tother\tinflammatory\tdisorders\t(\nGrün\tand\tBlumberg,\n2006\n).\tCategories\tof\tcommon\tpollutants\tinclude\tpersistent\torganic\tpollutants\t(POPs),\theavy\tmetals,\nand\tair\tpollution.\tPOPs\tinclude\tpolychlorinated\tbiphenyls\t(PCBs),\n\torganochloride\tpest... | [
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organochloride\tpesticides,\tand\nendocrine\tdisruptors,\thormone-like\tcompounds\tthat\tmimic\tnatural\thormones\tand\tdisrupt\tthe\tnormal\nfunctioning\tof\tthe\tendocrine\tsystem,\twhich\tincludes\taltering\tnormal\tgene\texpression\tpatterns.\tSee\nreviews\tby\t\nMuscogiuri\tet\tal\t(2017)\n\tand\tby\t\nDarbre\t(20... | [
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and\tby\t\nDarbre\t(2017)\n\tfor\tadditional\tinformation.\nThe\tgut\tmicrobiota\trefers\tto\tthe\tcommunity\tof\tdifferent\tmicroorganisms\t(bacteria,\tyeast,\n\tviruses)\nthat\tlive\twithin\tthe\tdigestive\ttract.\tThe\tgut\t“\nmicrobiome\n”\tthat\tis\toften\tspoken\tof\ttechnically\trefers\nto\tthe\tgenomes\tof\tthe... | [
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themselves\t(the\t“microbiota”).\tThese\torganisms\tcan\tbe\tbeneficial\tor\tpathogenic.\tThe\tbenefits\ninclude\tmaintenance\tof\tthe\tintegrity\tof\tthe\tdigestive\ttract,\twhich\tpromotes\tdigestive\tfunctions\tand\nthe\n\tintegrity\tof\tthe\tbarrier\tfunction\tof\ta\thealthy\tgut\tmucosa.\tThe\tmicrobiota\talso\tco... | [
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nutritionally\tby\tsynthesizing\tfolate,\tbiotin,\tand\tvitamin\tK\tand\tdigesting\tinsoluble\tfiber\tto\tgenerate | [
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short-chain\tfatty\tacids\tthat\tserve\tas\tfuel\tfor\tenterocytes.\tEarlier\tin\tthis\tchapter\tit\twas\tnoted\tthat\ngenomic\ttechnology\thas\tbeen\tsuccessfully\tapplied\tto\tidentifying\tthe\tmicrobes,\twhich\thas\tbeen\nhelpful\tfor\n\tresearch\tpurposes\tbut\talso\tfor\tlaboratory\ttesting\tso\tthat\tpathogenic\t... | [
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rapidly\tidentified\tand\tantimicrobial\ttherapy\tbegun.\nThe\tpresence\tof\tpathogens\tin\tthe\tmicrobiota\tcan\tcause\tmild\tto\tsevere\tdigestive\ttract\timbalances\nand\tcan\tlead\tto\tinfection\tand\terosion\tof\tthe\tgut\tbarrier,\tchronic\tactivation\tof\tthe\timmune\tsystem,\nand\tchronic\tinflammation.\tOne\to... | [
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of\tgram-negative\tbacteria\tis\tthat,\nas\tthey\tdie,\tthey\trelease\tlipopolysaccharide\t(LPS)\tmolecules\tfrom\ttheir\tcell\twalls.\tLPS\tis\ta\tpotent\nactivator\tof\tthe\tinnate\timmune\tsystem\tas\twell\tas\ta\tnumber\tof\tproinflammatory\tsystems,\twhich\nfurther\tpromotes\tand\tsustains\tchronic\tinflammation. | [
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further\tpromotes\tand\tsustains\tchronic\tinflammation.\nThe\tmicrobiota\tcomposition\talso\tappears\tto\tbe\timportant\tin\tweight\tmanagement.\tWhen\tthe\tgut\nmicrobiota\tof\tlower\tweight\n\tand\tobese\thuman\tbeings\tare\tcompared,\tthe\toverweight/obese\tindividuals\nhave\tlower\tfecal\tbacterial\tdiversity,\tim... | [
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0.052539... |
grade\tinflammation\t(\nLe\tChatelier\tet\tal,\t2013\n;\t\nMathur\t&\tBarlow,\t2015\n).\tStudies\tsuggest\tthat\tone\tof\nthe\tpotentially\timportant\tdifferences\tin\tobesity\tis\tthat\tthe\t\nFirmicutes:Bacteroidetes\n\tratio\tchanges\nsubstantially\tand\tthat\ta\tWestern-style\n\tdiet\thigh\tin\trefined\tcarbohydrat... | [
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diet\thigh\tin\trefined\tcarbohydrates\tand\tfat\tinfluences\tthe\nquantity\tand\tcomposition\tof\tthe\tmicrobiota\tassociated\twith\tweight\tgain\t(\nLey\tet\tal,\t2005\n;\t\nJumpertz\tet\nal,\t2011\n).\tSee\treviews\tby\t\nDuranti\tet\tal\t(2017)\n,\t\nSelber-Hnatiw\tet\tal\t(2017\n),\t\nDavis\t(2016)\n,\tand\nCastan... | [
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),\t\nDavis\t(2016)\n,\tand\nCastaner\tet\tal\t(2018)\n\tfor\tdetails\ton\tthe\trole\tof\tthe\tmicrobiota\tin\thealth\tand\tdisease.\nNutrition\tcan\texacerbate\tor\tprotect\tagainst\tthe\teffects\n\tof\tenvironmental\ttoxins\tand\tthe\tgut\nmicrobiota\t(\nHoffman\tet\tal,\t2017\n).\tDietary\tfats\tsuch\tas\tsaturated\... | [
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).\tDietary\tfats\tsuch\tas\tsaturated\tfats\tcan\tenhance\tthe\nproinflammatory\teffects\tof\tpollutants\twhereas\tomega-3s\tcan\tinterfere\twith\tthe\tsignaling\tprocess\tand\ndownregulate\tinflammation.\tDiets\trich\tin\tbioactive\tcomponents\tthat\tserve\tas\tantioxidants\tor\nantiinflammatory\tagents\tcan\tdiminis... | [
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Box\t6.4\n).\tSimilarly,\nnutrition\tcan\talter\tthe\tmicrobiota\tand\tpromote\thealth\tor\tdisease.\nFinally,\tidentifying\tthe\tmechanisms\tby\twhich\tenvironmental\tcues\tlead\tto\talterations\tin\tgene\nexpression\tis\ta\tmajor\tresearch\tfocus.\tOne\tof\tthe\tepigenetic\tassociations\tthat’s\tbeen\tidentified\trel... | [
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to\tthe\tdistinction\tbetween\tinflammation\tinduced\tby\tobesity\tcompared\twith\tinflammation\tinduced\tby\ninfection\tor\ttissue\ttrauma.\n\tObesity-induced\tinflammation\tis\tsystemic\trather\tthan\tlocalized\tand\tis\ta\nlow-intensity\tbut\tchronic\treaction\twhereas\tthe\tclassic\tinflammatory\tprocess\tis\tself-... | [
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like\treceptor\t(TLR)\tsignaling\tpathway\tinvolves\ta\tfamily\tof\tproteins.\tTLR4\tis\ta\tmajor\tcomponent\tof\nobesity-induced\tinflammation.\tActivation\tof\tthis\tsignaling\tsystem\tpromotes\tgene\texpression\tof\ninflammatory\tcytokines\tand\tNF-κB\n\tregulated\tproinflammatory\tgenes\t(\nRocha\tet\tal,\t2016\n;\... | [
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Rocha\tet\tal,\t2016\n;\t\nRogero\tand\nCalder,\t2018\n).\nActivation\tof\tthe\tTLR4\tpathway\toccurs\tthrough\tthe\tpresence\tof\tenvironmental\ttriggers,\tsuch\tas\nsaturated\tfatty\tacids\t(supplied\tby\tthe\tdiet\tor\tfrom\ttriglycerides\tstored\tin\tadipose\ttissue)\tand\tLPS\n(produced\tby\tbacteria\tthat\tpopula... | [
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Rocha\tet\tal\t(2018)\n\tsuggest\tthat\tsaturated\tfatty\nacids\talter\tthe\tmicrobial\n\tecology\tof\tthe\tgut\tand\tresult\tin\tincreased\tbacterial\tproduction\tof\tLPS,\nwhich\tis\ta\tknown\tactivator\tof\tthe\tTLR4\tsignaling\tpathway.\tFurther,\tthis\tincrease\tin\tLPS\tleads\tto\noxidative\tstress\tthat\tin\ttur... | [
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0.041... |
oxidized\tphospholipids\tthat\tare\talso\tknown\ttriggers\tof\tthe\tTLR4\tsystem.\tThe\televated\tlevels\tof\nsaturated\tfatty\tacids\tfurther\texacerbate\n\tthe\tsituation\tby\tcontributing\tadditional\tLDL-cholesterol\tin\nthe\tpresence\tof\toxidative\tstress\tthat\tincreases\tthe\tamount\tof\toxidized\tLDL,\twhich\t... | [
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atherogenesis.\tThe\tTLR4\tsignaling\tpathway\tis\talso\tconnected\tto\tthe\tactivation\tof\ttranscription\nfactors\tsuch\tas\tNF-κB\t(see\t\nBox\t6.3\n),\twhich\tregulates\texpression\tof\ta\tnumber\tof\tproinflammatory\ngenes\tthat\tproduce\tcytokines\tand\tother\tinflammatory\n\tmediators.\tIt’s\teasy\tto\tsee\thow\... | [
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mediators.\tIt’s\teasy\tto\tsee\thow\tthe\tobesity-\ninduced\tinflammatory\tresponse,\tonce\tinitiated,\twould\tself-perpetuate\tin\tthe\tpresence\tof\tsuch\nenvironmental\tconditions.\tThe\tomega-3\tpolyunsaturated\tfatty\tacids\teicosapentaenoic\tacid\t(EPA)\tand\ndocosahexaenoic\tacid\t(DHA)\tsupplied\tthrough\tfood... | [
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signaling\tcascades\tand\thave\tan\tantiinflammatory\teffect\tby\tpreventing\n\tactivation\tby\teither\tthe\nsaturated\tfats\tor\tLPS.\tReviews\tby\t\nLopomo\tet\tal\t(2016)\n\tand\t\nHoffman\tand\tHennig\t(2017)\n\texamine\nvarious\ttopics\trelating\tto\thow\tepigenetic\tmodifications\tare\trelated\tto\tobesity,\tincl... | [
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0.054276708513498306,
0.09087083488702774,
-0.029195014387369156,
0.0030616873409599066,
0.06... |
transgenerational\teffects\tof\tthese\tchanges\tand\twhat\tthat\tmeans\tfor\tfuture\tgenerations.\nVascular\tdisease\nThe\tcomplexity\tof\tvascular\tdisease\tprovides\tnumerous\topportunities\tfor\tgenomic\n\tanalysis\tto\thelp\ndistinguish\tamong\tthe\tvarious\tsubtypes\tas\twell\tas\tto\tapply\tpharmacogenomic\ttesti... | [
0.0341331847012043,
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0.04957... |
applications\talready\tin\tuse\tconcern\tmedications\trelating\tto\tblood\tclotting\t(warfarin)\tand\tplatelet\naggregation\t(clopidogrel).\t\nBox\t6.14\n\tgives\tan\toverview\tof\tthe\tclinical\tutility\tof\tthis\ttype\tof\ttesting.\nA\tlarge\tproportion\tof\tthe\tvascular\tdisorders\tcommonly\tseen\tin\tclinic\tare\t... | [
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0.04722225293517113,
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0.014434993267059326,
0.04467662423849106,
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0.019590996205806732,
0.038... |
associations\tto\tdiet\tand\tlifestyle:\thypertension\tand\tdyslipidemia\t(cardiovascular,\tcerebrovascular,\nand\tperipheral\tvascular\tdiseases;\televated\tLDL-cholesterol,\tdecreased\tHDL-cholesterol,\tand\nhypertriglyceridemia).\tEach\tof\tthese\tchronic\tdisorders\tdecreases\tquality\tof\tlife,\tincreases\tmedical | [
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0.08087311685085297,
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-0.016545260325074196,... |
costs,\tand\televates\trisk\tof\tpremature\tdeath.\tAs\twith\tother\tchronic\tdisorders,\tlow-grade\tinflammation\nand\toxidative\n\tstress\tare\tassumed\tto\tplay\tan\timportant\trole\tin\tconverting\tdisease\tsusceptibility\tto\ndevelopment\tof\tdisease.\tFortunately,\tthe\tmajor\tenvironmental\ttriggers\tthat\tpromo... | [
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0.062201954424381256,
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0.09566055238246918,
0.09340028464794159,
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0.0734... |
are\tlifestyle\tchoices:\tdiet,\texercise,\tand\tsmoking,\teach\tof\twhich\tis\tmodifiable.\nGene\tvariants\tand\tvascular\tdisease\nThe\tearliest\tgene\tvariants\tincorporated\tinto\tassessment\ttesting\tare\tcandidate\tgenes\tthat\tencode\nproteins\tknown\tto\tbe\tassociated\twith\tvascular\tdisease:\tthose\tthat\tsu... | [
0.054813310503959656,
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0.07647727429866791,
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0.07538102567195892,
0.09077372401952744,
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0.021690722554922104,
0.063... |
chronic\tinflammation\tand\toxidative\tstress,\tformation\tof\tblood\tclots,\tpredisposition\tto\thigh\tblood\npressure,\tor\tdevelopment\tof\tdyslipidemia\t(\nCurti\tet\tal,\t2011\n).\tThe\tproinflammatory\tvariants\tinclude\nCRP,\tIL1\nß,\t\nIL6,\n\tand\t\nTNF\n\tdiscussed\tin\tthe\tInflammation\tsection\tof\tthis\tc... | [
0.02224676124751568,
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0.060159627348184586,
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0.03037452884018421,
0.11149625480175018,
0.06411395221948624,
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0.06620781123638153,
0.09756634384393692,
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0.012060579843819141,
0.047... |
predisposition\n\thas\tbeen\tassociated\twith\tthe\tglutathione-S-transferase\tgenes\t\nGSTM1,\tGSTP1,\tGSTT1, | [
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0.03332431614398956,
0.1576322317123413,
0.022960567846894264,
0.04148009791970253,
0.04506488... |
and\tthe\tsuperoxide\tdismutase\tenzymes\t\nSOD2\n\tand\t\nSOD3.\n\tFor\tblood\tclot\tformation\tand\tsusceptibility\nto\tvenous\tthrombosis,\tthe\tmost\tcommonly\tincluded\tvariant\tis\tFactor\tV\tLeiden\t(\nF5\n).\tThe\thypertension\nvariant\thas\tbeen\t\nACE,\n\tthe\tgene\tthat\tencodes\tangiotensinogen-converting\t... | [
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0.08814440667629242,
0.1322062909603119,
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0.03... |
variants\tare\tthose\tthat\tcode\n\tfor\tthe\tproteins\tinvolved\tin\tthe\tvarious\tlipoproteins,\tsuch\tas\t\nAPOA1,\nAPOA2,\tAPOA5,\n\tand\t\nAPOE.\nConsidering\tthe\tmultiple\taspects\tof\tboth\tcardiovascular\tand\tcerebrovascular\tdisease,\tthere\twill\nlikely\tbe\tmany\tmore\tvariants\tidentified\tbefore\ta\tcomp... | [
0.02140755020081997,
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0.061905231326818466,
0.09897496551275253,
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0.016673166304826736,
0.053096... |
constructed.\tThat\tsaid,\tinformation\tfrom\tthe\tpresently\tavailable\tvariants\tcan\tprovide\tinsight\tinto\npotential\tsusceptibilities\n\tto\tdeveloping\tvascular\tdisease\tbut\texpect\tstronger\tassociations\tto\tbe\nidentified\tas\tresearch\tcontinues.\tIn\taddition\tto\tthe\tgoal\tof\tscreening\tmultiple\tpopul... | [
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0.09857115894556046,
0.06160007417201996,
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0.01783975586295128,
0.027739... |
variants\tthat\toccur\tfrequently\tand\thave\ta\tstrong\tassociation\twith\tvascular\tdisease,\tthere\tis\talso\ta\nneed\tto\tidentify\tvariants\tthat\tpredict\tsusceptibility\tamong\tthe\tspecific\tpopulations.\tFor\texample,\nvenous\tthromboembolism\n\t(VTE)\tis\tmore\tprevalent\tin\tAfrican\tAmericans\tthan\tin\toth... | [
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0.123700812458992,
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0.0111108822748065,
0.004289... |
but\tfrequently\tmissed\tby\tgene\tpanels\tthat\tderive\tfrom\tEuropean\tpopulations.\tOne\tpromising\tlead\nhas\tcome\tfrom\ta\tGWAS\tstudy\tthat\tfound\tthree\tvariants\tin\tthe\tthrombomodulin\tgene\t(THBD)\tthat\ndecreases\texpression\tand\tincreases\tthe\trisk\tof\tVTEs\tin\tAfrican\tAmericans\t(\nHernandez\tet\ta... | [
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0.10044176876544952,
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0.09469746053218842,
-0.01364... |
Hernandez\tet\tal,\t2016\n).\nAt\tthis\tpoint\ta\tcombination\tof\tcandidate\n\tgene\tand\tGWAS\tstudies\thas\tidentified\tover\t400\tvariants\nthat\tinfluence\thypertension\tsusceptibility\talone.\tSimilar\tto\tchallenges\twith\tcategorizing\tcancer\tas\ta\nsingle\tdisease,\tthe\tcomplexity\tof\tvascular\tdisease\tmak... | [
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0.028136882930994034,
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0.024197911843657494,
0.06726202368736267,
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0.016433127224445343,
0.03043... |
have\ta\tstrong\tassociation\twith\ta\tspecific\taspect\tof\tsusceptibility\tto\tdeveloping\tvascular\tdisorders.\tAs\na\tresult,\teach\taspect\tof\tthis\tcomplex\n\tdisease\twill\tcontinue\tto\tbe\tinvestigated\tto\tfind\tvariants\tthat\nhave\ta\tstrong\tassociation\twith\tdistinct\tsubcategories\tof\tvascular\tdiseas... | [
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0.10281047970056534,
0.10010005533695221,
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0.00591534748673439,
0.08479... |
Epigenetics\tand\tvascular\tdisease\nAs\tit\thas\tbecome\tobvious\tthat\tnumerous\tenvironmental\tfactors\tincrease\tsusceptibility\tto\tdeveloping\nvascular\tdisorders,\tepigenetic\tmechanisms\thave\tbecome\tan\tadditional\tfocus\tof\tnutritional\tgenomic\nresearch\tinto\tvascular\tdisease.\n\tEpigenetic\tresearch\twi... | [
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0.06260964274406433,
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0.10422957688570023,
0.10321950167417526,
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0.0635671... |
Epigenetic\tresearch\twill\thelp\tdefine\tthe\tmechanisms\tby\twhich\nlifestyle\tchoices\tinfluence\tgene\texpression.\tIt\talso\tprovides\tinsight\tinto\tlifestyle-oriented\ttherapeutic\noptions\tfor\tmanaging\texisting\tdisease\tand\tpreventing\tfuture\tdisease.\nGiven\tthe\tcomplexity\tof\tvascular\tdisease\tand\tth... | [
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0.06331689655780792,
0.1064663678407669,
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... |
GWAS\tloci\tfound\tto\thave\tan\tassociation\twith\tthese\tdisorders,\tthe\n\tmost\teffective\thealth-promoting\napproach\tfor\tnutrition\tprofessionals\tis\tto\taddress\tthe\tmodifiable\tlifestyle\tchoices\tavailable\tto\tclients.\nWith\tthe\tescalating\tglobal\tprevalence\tof\tvascular\tdisease,\tas\twell\tas\tobesit... | [
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0.061503056436777115,
0.10766733437776566,
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0.006086928304284811,
0.038... |
vascular\tsusceptibility,\texpanding\tthe\ttherapeutic\tapproach\tto\tinclude\tmodifiable\tlifestyle\tfactors\nbeyond\tfood\tchoices\twill\tbe\tneeded.\tThese\tbehavioral\tchanges\n\tentail\teliminating\tsmoking,\tcurbing\nalcohol\tintake,\tavoiding\tfood-\tand\tair-borne\ttoxins,\tadopting\tan\tantiinflammatory\tdiet,... | [
0.01587747409939766,
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0.06796781718730927,
0.021969590336084366,
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0.08592037856578827,
0.030166970565915108,
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0.03142476826906204,
0.09949188679456711,
-0.0561433807015419,
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0.05489... |
managing\tstress,\tdeveloping\tsupportive\trelationships,\tand\tgetting\tsufficient\tquantity\tand\tquality\tof\nsleep.\tThe\tepigenetic\tcomponent\tof\tchronic\tdisease\tdevelopment\tappears\tto\tbe\tstrong,\twhich\nsuggests\tthat\tall\tof\tus\thave\tat\tleast\tsome\tlevel\tof\tsusceptibility\tthat,\n\tif\tcontinually... | [
0.034946270287036896,
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0.05072222277522087,
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0.0063807968981564045,
0.06812971830368042,
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0.07911096513271332,
0.11180547624826431,
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0.048486582934856415,
0.04... |
if\tcontinually\tchallenged\twith\ninappropriate\tlifestyle\tchoices,\twill\tlead\tto\tmanifestation\tof\tany\tnumber\tof\tinflammation-based\nchronic\tdisorders.\nThe\tnutrition\tpractice\tof\tthe\tfuture\twill\tincorporate\taspects\tof\tnot\tonly\tgenomics\tand\tepigenomics\nbut\tcontemporary\tneuroscience\tand\tbeha... | [
0.0032970679458230734,
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0.04086170345544815,
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0.007452112156897783,
0.08039428293704987,
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0.0017319339094683528,
0.041191376745700836,
0.10555465519428253,
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0.0011035731295123696,
0.0... |
suited\tto\tdeliver\tthis\tinformation\tbut\talso\tto\tcounsel\n\tclients\tas\tthey\taddress\tthe\toften-challenging\nbehavioral\tchanges\tthat\tare\tneeded\tto\trestore\ttheir\thealth\tfrom\tvascular\tand\tother\tchronic\tdiseases\nand\tprevent\tdisease\tsusceptibility\tfrom\tbecoming\tan\tinevitability.\nSummary | [
0.009658710099756718,
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0.0255217... |
Summary\nGenomics,\tepigenetics,\tand\tthe\tvarious\t“omic”\tdisciplines\tthat\thave\temerged\tare\tadding\ta\tnew\ndimension\tto\tnutrition\tscience\tand\tmedical\tnutrition\ttherapy.\tIt\thas\topened\n\tup\ta\tnew\tway\tof\tthinking\nabout\thow\tfood\tinfluences\tgene\texpression\tand,\tultimately,\tour\tdisease\tsus... | [
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0.05243264511227608,
0.0007749235955998302,
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0.03112892620265484,
0.04471118748188019,
0.002207905752584338,
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0.06139222905039787,
0.04361482709646225,
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-0... |
nutrition\tmoves\tinto\tan\tera\tof\tprecision\thealth,\tthe\tmolecular\tand\tbiochemical\taspects\tof\tnutrition\nwill\tbecome\tincreasingly\timportant\ttools\tfor\tnutrition\tprofessionals.\tAs\ta\thuman\tbeing,\teach\tclient\nwill\tbe\tgenerally\tlike\tother\tmembers\tof\tour\tspecies\tyet\thave\tsufficient\tgenetic... | [
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0.023690663278102875,
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0.02145439386367798,
0.06745646893978119,
0.005191320553421974,
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0.07475356757640839,
0.08089737594127655,
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0.028264... |
heterogeneity\tto\tgive\neach\tdistinctive\tdifferences.\tThe\tvision\tfor\tthe\tera\tahead\tis\tto\tget\tever\tcloser\tto\tbeing\table\tto\tassess,\ndiagnose,\tintervene,\tmonitor,\tand\tevaluate\teach\tclient’s\tunique\tsituation.\tThis\tdepth\tof\tinformation\nwill\tbe\thelpful\tin\tdeveloping\tinterventions\tthat\t... | [
0.07541412860155106,
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0.07017868012189865,
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0.08645448088645935,
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0.012145383283495903,
0.07381101697683334,
0.10857360064983368,
-0.04256294667720795,
0.042720116674900055,
0.0116... |
restore\thealth,\tas\twell\tas\tidentify\tearly\tgenetic\tsusceptibilities\n\tand\tprevent\tthem\tfrom\tdeveloping\ninto\tdisease.\nDuring\tthe\tpast\t50\tyears\tthe\tfocus\tfor\thealth\tcare\thas\tbeen\ton\ttreating\tdisease,\tand\tphysicians\nhave\thad\tincreasingly\tsophisticated\tdrugs,\tsurgery,\tand\ttechnologies... | [
0.009345906786620617,
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0.10342002660036087,
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0.033257003873586655,
0.09210802614688873,
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0.04669627174735069,
0.09375345706939697,
0.00738515006378293,
0.02507593110203743,
0.0074225... |
challenge.\tHowever,\twith\tthe\tunderstanding\tthat\tchronic\tdisease\tis\tgenetically\tbased\tbut\nenvironmentally\tinfluenced,\tthe\tfocus\tis\tnow\ton\ttargeted\tintervention\tand\n\tprevention.\tAlthough\tthe\nfirst\tapplications\tof\tthis\tchanged\tfocus\tin\thealth\tcare\tinvolve\tthe\tmedical\tand\tpharmaceutic... | [
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0.09127574414014816,
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0.06755484640598297,
0.09190807491540909,
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0.06790997833013535,
0.04067253693938255,
-0.10260908305644989,
0.029981674626469612,
0.091... |
aspects\tof\tacute\tcare,\tnutrition\ttherapy\tis\texpected\tto\tfigure\tprominently\tas\ta\tcornerstone\tof\tcare\tin\npreventing\tand\tmanaging\tchronic,\tdiet-and-lifestyle-related\tdiseases.\nAlthough\tour\tgenetic\tmakeup\tsets\tthe\tstage,\tenvironmental\tfactors\tsuch\tas\tnutrition\tand\tother\nlifestyle | [
0.04966466501355171,
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0.06087038293480873,
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0.00813501887023449,
-0.00307... |
lifestyle\n\tchoices\tdetermine\twho\tamong\tthe\tsusceptible\tactually\tdevelops\tchronic\tdisease\t(\nHenning\tet\nal,\t2018\n).\tIn\taddition\tto\tour\tfood\tchoices,\tother\tlifestyle\tchoices\talso\tepigenetically\tinfluence\nfunction\tand\tare\tas\tcentral\tas\tfood\tif\tour\tclients\tare\tto\tenjoy\trobust\theal... | [
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-0.0... |
overview\tby\t\nAbdul\tet\tal\t(2018)\n\ton\tthe\tinfluence\tof\tlifestyle\tchoices\ton\tepigenetic\tmechanisms\tand\nhealth\tsuggests\n\tthat\tthe\trole\tof\tthe\tnutrition\tprofessionals\twill\tbe\texpanding\tin\tthe\tyears\tahead.\nSimilarly,\tsocial\tepigenomics\tis\ta\tdeveloping\tfield\tthat\twill\tappeal\tto\tnu... | [
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-0.0... |
history\tof\tconcern\tfor\tthe\thealth\tof\tthe\tunderserved\tindividuals\tin\tour\tsociety.\tNutrition | [
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7\nInflammation\tand\tthe\npathophysiology\tof\tchronic\ndisease\nDiana\tNoland,\tMPH,\tRDN,\tCCN,\tIFMCP,\tLD\nKEY\tTERMS\nadipokines\nallostasis\nantecedents\nautoimmune\nautophagy\nbiochemical\tindividuality\nbody\tfluid\tviscosity\nC-reactive\tprotein–high\tsensitivity\t(CRP-hs)\ncoenzyme\tQ\n10\nconditionally\tess... | [
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curcumin\ncyclooxygenases\t(COX)\ncytochrome\tP450\tenzymes\ncytokines\ndelta-6-desaturase\neicosanoid\tcascade\nenteroimmunology\ngenesis\tof\tdisease\nglutathione\nhealth\tcontinuum\nhyperinsulinemia\ninflammation\ninterleukin-6\t(IL-6)\nleukotrienes\nlipoic\tacid\nlipoxins\nlipoxygenases\t(LOX)\nlong-latency\tnutrie... | [
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0.01... |
maresins\nmediators\nmetabolic\tsyndrome\n“new-to-nature”\tmolecules\nnutrient-partner\tprinciple\nnutrition\ttransition\nprolonged\tinflammation\nprostaglandins\nprotectins\nreactive\toxygen\tspecies\t(ROS) | [
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0.0233581364... |
resolvins\nquercetin\nsarcopenia\nsarcopenic\tobesity\nsedimentation\trate\nspecialized\tproresolving\tmediators\t(SPM)\nsystems\tbiology\ntotal\tinflammatory\tload\ntriage\ttheory\ntriggers\ntumor\tnecrosis\tfactor\talpha\t(TNF-α)\nvagal\tnerve\nvisceral\tadipose\ttissue\t(VAT)\nxenobiotics\nEpidemic\tof\tchronic\tdis... | [
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0.0867651... |
Chronic\tdisease\tin\tthe\ttwenty-first\tcentury\n\tis\ta\trecent\tphenomenon\tin\tthe\thistory\tof\tthe\thuman\trace.\nIts\trecognition\tbegan\tafter\tWorld\tWar\tII\tat\tthe\tsame\ttime\tthe\tvery\tsignificant\t\nnutrition\ttransition\nbegan\tto\toccur,\tfirst\tin\tindustrialized\tcountries,\tthen\tglobally\t(see\t\n... | [
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0.08116679638624191,
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0.024500... |
Chapter\t10\n\t\nFocus\tOn\n:\tNutrition\nTransition).\tThe\tnutrition\ttransition\tincludes\ttechnology\tthat\tenables\tsynthesis\tof\t\n“new-to-nature”\nmolecules\n\t(\nBland,\t2007\n),\trapid\tincreases\n\tin\tenvironmental\ttoxin\texposure,\tand\tdecreased\tphysical\nactivity.\tNew\tbehavior\tpatterns\thave\tpromot... | [
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0.08423920720815659,
0.09948091953992844,
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0.02... |
convenience\tfood\tconsumption\tand\teating\tout.\tAll\tof\tthese\tchanges\tare\taccompanied\tby\tthe\nincreased\tuse\tof\tprocessed,\tless\tnutrient-dense\tfood;\tdecreased\tintake\tof\twhole\tfruits\tand\nvegetables;\tand\tincreased\tconsumption\tof\tsugar\tand\thigh-sugar–containing\n\tfoods.\tThese\tcomponents | [
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-0.0346531... |
foods.\tThese\tcomponents\nof\tthe\tnutrition\ttransition\tdo\tnot\tappear\tto\thave\tbeen\tbeneficial\tto\tthe\thuman\trace,\tbecause\tthe\neffects\tare\trapidly\tand\tglobally\tincreasing\tthe\trisk\tof\tbeing\toverweight\tand\tobese,\talong\twith\nproducing\tepidemic\tlevels\tof\tchronic\tdiseases\tat\tearlier\tages... | [
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Hruby\tand\tHu,\t2015\n)\t(see\t\nClinical\nInsight\n:\tIs\tChronic\tDisease\tan\tEpidemic?\n).\nCLINICAL\tINSIGHT\nIs\tChronic\tDisease\n\tan\tEpidemic?\n•\t\nAccording\tto\tthe\tCenters\tfor\tDisease\tControl\t(\nCDC,\t2018\n)\tand\tthe\tWorld\tHealth\nOrganization\t(\nWHO,\t2018\n):\n•\t\n1\tout\tof\t3\tU.S.\tadults... | [
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0.083... |
•\t\n70%\tof\tU.S.\tdeaths\twill\tbe\tfrom\tchronic\tdisease.\n•\t\nGlobal\tcancer\trates\tcould\tincrease\tby\t70%\t2015\tto\t2035.\n•\t\nTwo\tof\tthree\tU.S.\tadults\twill\tbe\toverweight\tor\tobese.\n•\t\nOne-third\tof\tcancer\tdeaths\twill\tbe\tdue\tto\tthe\n\tfive\tleading\tbehavioral\tand\tdietary\trisks\t(high | [
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0.05... |
five\tleading\tbehavioral\tand\tdietary\trisks\t(high\nBMI,\tlow\tfruit\tand\tvegetable\tintake,\tlack\tof\tphysical\tactivity,\tsmoking,\tand\talcohol\tuse).\n•\t\nYounger\tAmericans\twill\tlikely\tface\ta\tgreater\trisk\tof\tmortality\tthroughout\tlife\tthan\tprevious\ngenerations\t(related\tto\tobesity).\n• | [
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generations\t(related\tto\tobesity).\n•\t\nThe\tthree\tmost\tpreventable\trisk\tfactors\tare\tunhealthy\tdiet,\tsmoking,\tand\tphysical\tinactivity.\nDespite\tthe\tfact\tthat\tthe\n\tUnited\tStates\tspends\tmore\tmoney\ton\thealth\tcare\tthan\tany\tother\tcountry,\naccording\tto\ta\treport\tby\tthe\tCenters\tfor\tDisea... | [
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care\tdollars\tin\tthe\tUnited\tStates\tare\tspent\ton\tchronic\tdisease\tmanagement\t(\nCDC,\t2018\n).\tAs\tpeople\nare\tliving\tlonger,\tthe\tnumber\tof\tyears\tspent\tliving\twith\tdisability\thas\tincreased.\tThe\tfact\tof\tthe\ngrowing\tincidence\tof\tchronic\tdisease\n\thas\tdriven\tthe\tglobal\tcivilian\tand\tgo... | [
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-0.01... |
has\tdriven\tthe\tglobal\tcivilian\tand\tgovernmental\thealth\tcare\nsystems\tto\tseek\tnew\tanswers\tto\tthis\tnearly\tuniversal\tchallenge.\nThe\tglobal\teffort\tto\timprove\tunderstanding\tof\tthis\tchronic\tdisease\tphenomenon\tis\tbringing\tthe\nrealization\tthat\tthese\tchronic\tdiseases\thave\tlong\tincubation\t... | [
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0.00885042268... |
may\tnot\tbe\tobservable\tduring\ttheir\tearly\tstages\tand\tmay\tbe\tpresent\tin\tan\totherwise\n\thealthy-looking\nperson.\tFocusing\ton\tpreventive\tcare\twith\tearlier\tdetection\tof\tsigns,\tsymptoms,\tand\tbiomarkers\tthat\nwere\tpreviously\tthought\tinsignificant\tallows\tfor\ta\tchance\tto\treverse\tthe\tdiseas... | [
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0.0176... |
becomes\ta\tserious\taffliction.\tThe\tnew\tphenotype\tof\t“fat,\tfatigued,\tand\tin\tpain”\tin\tcombination\twith\nassociated\tconditions\tis\tdescriptive\tof\tmany\tchronic\tdisease\tstates\tconsidered\tto\n\tbe\tpreventable\n“lifestyle”\tdiseases.\tThe\tgenotype,\tor\tgenetic\tmakeup,\tof\ta\tperson\tmay\tincrease\t... | [
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-0.0103774... |
toward\ta\tchronic\tdisease,\tbut\tlifestyle—what\tone\teats\tand\tthinks\tand\twhere\tone\tlives—may\tbe\tthe\nmost\tpowerful\tcause\tof\tthese\t“lifestyle”\tchronic\tdiseases\t(\nCDC,\t2018\n;\t\nElwood\tet\tal,\t2013\n).\nConcepts\tof\tchronic\tdisease\tpathophysiology\nAn\tunderstanding\tof\tthe\tfollowing\tbasic\t... | [
0.013207987882196903,
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0.06930283457040787,
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0.03394545242190361,
0.05421195924282074,
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0.07549960911273956,
0.10946239531040192,
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0.03341442346572876,
0.0109... |
characteristics\tof\tchronic\tdisease\tpathophysiology:\t\nsystems\tbiology\n,\t\nallostasis\n,\t\nautophagy\n,\tthe\nhealth\tcontinuum\n,\t\ngenesis\tof\tdisease\n,\t\nlong-latency\tnutrient\tinsufficiencies\n,\tand\t\nnutrient-\npartner\tprinciple\n.\nSystems\tbiology\nThe\temerging\tnew\tparadigm\tof\tsystems\tbiolo... | [
0.01755242608487606,
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0.06373539566993713,
0.09913107752799988,
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0.032309457659721375,
0.069717228... |
disease.\tSystems\tbiology\tis\n\tbased\ton\tthe\tunderstanding\tthat\tall\tbody\tsystems\twork\ttogether\ninterdependently.\tIt\tis\tan\tinterdisciplinary\tfield\tthat\tfocuses\ton\tcomplex\tinteractions\twithin\nbiological\tsystems\tand\tincludes\tthe\tintersection\tof\tbiology,\tinformatics,\tcomputer\tscience,\tphy... | [
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0.03... |
and\tengineering.\tUsing\tthis\tcollaborative\tapproach,\tscientists\tcan\tidentify\tbiomarkers\tand\tgenetic,\ndietary,\tand\tlifestyle\tinfluences\ton\thealth\n\tand\tconstruct\tinnovative\tmodels\tfor\tprevention\tand\ntreatment\tof\tdisease\t(\nTrachana\tet\tal,\t2018\n).\nThe\tglobal\tmovement\tin\thealth\tcare\tt... | [
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0.06674282997846603,
0.09986034035682678,
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0.00816841796040535,
0.02853921... |
approach\tto\tmedicine\tis\texpanding.\tThe\tregistered\tdietitian\tnutritionist\t(RDN),\tas\ta\tmember\tof\tthe\nhealth\tcare\tteam,\thas\ta\tlarger\trole\tto\timprove\tthe\tnutritional\tstatus\tof\teach\tindividual\twith\tdietary\nand\tlifestyle\n\tmodifications\tas\ta\tfoundational\tcomponent\tof\taddressing\tchroni... | [
0.03641646355390549,
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0.04613158851861954,
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0.058533165603876114,
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0.06946297734975815,
0.10960691422224045,
-0.012783559039235115,
0.04140597581863403,
0.04360... |
Allostasis\nThis\tis\ta\tcondition\tof\tmetabolic\tstability\twith\tadjustments\tfor\tenvironmental\tinfluences\tand\tstresses\nthrough\tphysiologic\tchanges.\tAllostasis\twill\tbe\testablished\teven\tunder\tinflammatory\tconditions\tbut\nnot\talways\tfor\toptimal\tfunction.\tThe\tmaintenance\tof\tthese\tchanges\tover\... | [
0.061305493116378784,
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0.08013737946748734,
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0.005496860947459936,
0.07653086632490158,
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0.056790199130773544,
0.07910968363285065,
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0.04681152105331421,
0.0299... |
lead\tto\twear\n\tand\ttear\tof\tthe\tbody.\t\nInflammation\n\tmay\tbe\tinitiated\tfor\ttissue\tadaptation\tand\tyet\tmay\ninvolve\tcollateral\tdamage.\tInflammation\tis\tparticularly\trelevant\tto\tobesity\tand\tits\tassociated\tadverse\nhealth\tconditions,\tsuch\tas\ttype\t2\tdiabetes,\tcardiovascular\tdisease,\tauto... | [
0.01668347604572773,
-0.10290513187646866,
0.056670259684324265,
-0.03207444027066231,
-0.11219731718301773,
0.006366792134940624,
0.09031689912080765,
0.011100315488874912,
-0.030084921047091484,
0.08383074402809143,
0.06784594804048538,
-0.027133051306009293,
0.016305308789014816,
0.0310... |
ensuing\tsystemic\tlow-grade\tinflammation\tpromotes\ta\tmultitude\tof\tpathologic\tand\tself-perpetuating\nevents,\tsuch\n\tas\tinsulin\tresistance\t(\nMather\tet\tal,\t2013\n),\tendothelial\tdysfunction,\tand\tactivation\tof\noncogenic\tpathways\t(\nBaffy\tand\tLoscalzo,\t2014\n).\nFor\tthe\tnutritionist\tin\tclinica... | [
-0.0103639867156744,
-0.03592737391591072,
0.08802370727062225,
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-0.003974694758653641,
0.08882728964090347,
0.025930354371666908,
0.004510694183409214,
0.057418711483478546,
0.10817671567201614,
-0.010890861041843891,
-0.005200591403990984,
0.07... |
inflammation\tat\tthe\tcellular-molecular\tlevel\tavailable\tindirectly\tby\tusing\timproved\tlaboratory\ttesting\ntechnology\tand\tscientific\tdiscovery\tof\tbiochemical\tmarkers.\tFor\n\texample,\tthe\tbiomarker\t\nC-reactive\nprotein–high\tsensitivity\t(CRP-hs)\n\thas\tbeen\tshown\tto\tbe\tthe\tstrongest\tunivariate... | [
-0.016027726233005524,
-0.12978215515613556,
0.04833461344242096,
0.0023831857834011316,
-0.013329138047993183,
0.005171599797904491,
0.054708223789930344,
0.12342825531959534,
-0.0014366991817951202,
0.0708468034863472,
0.03153424710035324,
-0.027245761826634407,
0.05750221759080887,
0.11... |
has\tbeen\tshown\tto\tbe\tthe\tstrongest\tunivariate\tpredictor\tof\tthe\nrisk\tof\tcardiovascular\tevents.\tIt\tis\ta\tsystemic\tmarker\tof\tinflammation\twithin\tthe\tinternal\tmilieu\nrelated\tmost\toften\tto\tbacterial\tinfection,\ttrauma,\tand\tneoplastic\tactivity\twith\tacute\tand\tchronic\nexpression.\tSome\tst... | [
-0.010382210835814476,
-0.037680357694625854,
0.04370381683111191,
-0.03213552013039589,
-0.10017658770084381,
0.015197878703474998,
0.06584180891513824,
0.025446860119700432,
0.012600859627127647,
0.08034955710172653,
0.1082456111907959,
-0.06471478193998337,
0.0100801270455122,
0.0500732... |
acid\t(EPA)\tfrom\tfish\tand\nfish\toil\thas\tan\tantiinflammatory\teffect\tand\tsuppresses\tCRP-hs.\tRefer\tto\t\nChapter\t5\n\tfor\tadditional\ninformation\tabout\tCRP-hs.\nAutophagy\nAutophagy\n,\tor\t“self-eating,”\tis\ta\tmajor\tregulatory\tcellular\tmechanism\tproviding\tthe\tcells\tan\tability | [
-0.01994016207754612,
-0.06093026325106621,
0.03910473361611366,
-0.015638312324881554,
-0.07308616489171982,
0.032700348645448685,
0.09460132569074631,
0.03909739479422569,
-0.01922757364809513,
0.04216264933347702,
0.10604660212993622,
-0.10111044347286224,
-0.004835726693272591,
0.02727... |
to\tclean\tup\t“cellular\tdebris”\toccurring\tfrom\tnormal\tmetabolic\tactivity.\tIt\tis\ta\tsurvival\tmechanism\nrequired\tfor\tmaintaining\tcellular\n\thomeostasis\tafter\tinfection,\tmitochondrial\tdamage,\tor\tendothelial\nreticulum\tstress.\tAutophagy\tresults\tin\tthe\tlysosomal\tdegradation\tof\torganelles,\tunf... | [
-0.005452258978039026,
-0.08363404124975204,
0.0222359299659729,
-0.04510300233960152,
-0.12737031280994415,
0.009109203703701496,
0.0562613271176815,
0.024638431146740913,
0.00530256750062108,
0.0889681875705719,
0.07445239275693893,
-0.02460799738764763,
0.05337836220860481,
0.0438655130... |
foreign\textracellular\tmaterial\tthat\tprovides\ta\tmicroenvironment\tsupportive\tof\thealthy\ttissue.\tDefects\nin\tautophagy\thave\tbeen\tshown\tto\tresult\tin\tpathologic\tinflammation\tinfluencing\thealth\tand\tdisease\n(\nAbraham\tand\tMedzhitov,\t2011\n;\t\nMoloudizargari\tet\tal,\t2017\n;\t\nPrado\tet\tal,\t201... | [
0.021328579634428024,
-0.017892252653837204,
0.06086019054055214,
-0.07522402703762054,
-0.08904676884412766,
0.019764356315135956,
0.05654274672269821,
-0.04353921487927437,
0.00428215553984046,
0.04207234084606171,
0.09419301897287369,
-0.06328029930591583,
0.010701866820454597,
0.035512... |
Moloudizargari\tet\tal,\t2017\n;\t\nPrado\tet\tal,\t2014\n).\nHealth\tcontinuum\nHealth\tis\tmeasured\ton\ta\tcontinuum\tfrom\tbirth\tto\tdeath.\t“Health\tis\tthe\tperfect,\tcontinuing\nadjustment\tof\tan\torganism\tto\tits\tenvironment”\t(\nWyle,\t1970\n).\tChronic\tdisease\tmanagement\tfor\tan\nindividual\tmust\tincl... | [
-0.026025226339697838,
0.03259921446442604,
0.05692584440112114,
-0.02395360916852951,
-0.06231626123189926,
0.013388875871896744,
0.11038471013307571,
-0.03420389071106911,
-0.01203156728297472,
0.03136005997657776,
0.13083896040916443,
-0.043433211743831635,
0.042864155024290085,
0.01881... |
health\tcontinuum\n\thistory\tto\tdetermine\twhich\nfactors\talong\tthe\tway\trelate\tto\tone’s\tcurrent\thealth\tcondition.\tWhen\tcollecting\n\tthe\tpatient’s\thistory\nduring\tthe\tassessment,\tplotting\tthe\tperson’s\thealth\tmilestones\tas\tthey\trelate\tto\tmajor\tlife\tevents\tcan\nbe\thelpful.\tThis\tis\toften\... | [
-0.004554845858365297,
-0.018235374242067337,
0.024867642670869827,
-0.06275682896375656,
-0.14006856083869934,
0.022728748619556427,
0.06394098699092865,
-0.0026311841793358326,
-0.013260512612760067,
0.032473888248205185,
0.10007651150226593,
-0.003017430892214179,
0.04387091100215912,
-... |
Genesis\tof\tdisease\nTriggers\n,\t\nantecedents\n,\tand\t\nmediators\n\tare\tcritical\tterms\tthat\tare\tpart\tof\tthe\tgenesis\tof\tdisease\tthat\nunderlies\tthe\tpatient’s\tsigns\tand\tsymptoms,\tillness\tbehaviors,\tand\tdemonstrable\tpathology.\n\tTriggers\nare\tthe\tdistinct\tentities\tor\tevents\tthat\tprovoke\t... | [
0.025004155933856964,
-0.02573162131011486,
0.03424500301480293,
-0.012400374747812748,
-0.05282019078731537,
0.029017629101872444,
0.018002284690737724,
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0.11504072695970535,
0.0695299506187439,
-0.025263773277401924,
-0.018087606877088547,
0.0... |
for\tdisease\tformation;\thost\tresponse\tis\tan\tessential\tcomponent.\tAntecedents\tare\tcongenital\tor\ndevelopmental\taspects\tof\tthe\tindividual\tthat\tcan\tinclude\tgender,\tfamily\thistory,\tand\tgenomics.\tThese\nact\tto\tset\tthe\tstage\tfor\tthe\tbody’s\tresponse\tto\tthe\ttrigger.\tMediators\tare\tintermedi... | [
-0.008883540518581867,
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0.054175615310668945,
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0.002435956383123994,
0.07419659942388535,
0.013905304484069347,
0.009082133881747723,
0.08516889065504074,
0.07833702862262726,
-0.05792767181992531,
0.026389261707663536,
0.052... |
that\tare\tthe\nprimary\tdrivers\tof\tdisease;\tthese\tare\tbiochemical\t(\nDi\tGennaro\tand\tHaeggström,\t2012\n)\tbut\tcan\tbe\ninfluenced\tby\tpsychosocial\tfactors\tsuch\tas\tsmoking\tor\tstress\t(\nAvitsur\tet\tal,\t2015\n;\tsee\t\nFig.\t5.9\n\tin\nChapter\t5\n).\nLong-latency\tnutrient\tinsufficiencies\nLong-late... | [
0.0012549886014312506,
-0.046573787927627563,
0.037179119884967804,
-0.04370656982064247,
-0.03142867237329483,
-0.0007088611600920558,
0.007942995987832546,
0.061139706522226334,
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0.006710621993988752,
0.06704755127429962,
-0.06641745567321777,
-0.03979753702878952,
0... |
Long-latency\tnutrient\tinsufficiencies\n\t(i.e.,\tsubclinical\t[below-optimum]\tor\tdeficient\tnutrient\npools\tresulting\tfrom\tchronic\tpoor\tintake\n\tand\tgenotype)\tcontribute\tover\ttime\tto\tdevelopment\tof\nchronic\tdisease.\tNew\ttools\thave\tto\tbe\tincluded\tin\tnutrition\tpractice\tto\texpand\tbeyond\tjust... | [
0.0032582704443484545,
-0.04580384120345116,
0.05622359737753868,
-0.013725897297263145,
-0.06159309670329094,
-0.02857539802789688,
0.016018684953451157,
0.056903235614299774,
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0.029649851843714714,
0.09217508882284164,
-0.03544389456510544,
0.02075495943427086,
0.058... |
of\tovert\tclinical\tdeficiencies\t(\nHeaney,\t2012\n).\tThere\tmust\tbe\tfurther\tidentification\tof\tbiomarkers,\nusually\tbiochemical\tand\tphenotypic,\twhich\tare\tindicative\tof\tearly\tchronic\tdisease\tand\tare\tevidence | [
0.010303343646228313,
-0.03853755071759224,
0.07508224248886108,
-0.01973848044872284,
-0.08890283852815628,
0.030726660043001175,
0.043848637491464615,
0.015386544167995453,
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0.09367397427558899,
0.0653083324432373,
-0.10054298490285873,
-0.019379915669560432,
0.06065... |
based.\nThe\tnutrient\tdeficiencies\tdefined\tin\n\tthe\tearly\t1900s\tare\tthe\tend-stage\tand\tthe\tresult\tof\tspecific\nindex\tdiseases.\tAn\texample\tof\tthis\tis\tthe\tdiscovery\tthat\tvitamin\tC\tdeficiency\tcaused\tscurvy\tin\tBritish\nsailors.\tScurvy\tproduces\tobvious\tclinical\tsymptoms\tand\tdeath\twithin\... | [
-0.017928477376699448,
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0.020680775865912437,
-0.03305134177207947,
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0.08171156793832779,
0.0687064379453659,
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0.0403754785656929,
0.0641353502869606,
-0.0048090387135744095,
0.029108885675668716,
0.059... |
vitamin\tC\tintake.\tIn\tcontrast,\ta\tmore\trecent\tdiscovery\tis\tthat\tyears\tof\tsubclinical\tvitamin\tC\ndeficiency\t(without\tclassic\tscurvy\tsymptoms)\tcan\n\tcause\ta\tless\trecognizable\tform\tof\tscorbutic\nprogression\tin\tthe\tform\tof\tperiodontal\tgum\tdisease\t(periodontitis)\t(\nAlagl\tand\tBhat,\t2015... | [
-0.045585885643959045,
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0.004249892197549343,
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0.03854367509484291,
0.08952098339796066,
0.04590795189142227,
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0.05523572117090225,
0.05559016764163971,
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0.026639480143785477,
0.055... |
Alagl\tand\tBhat,\t2015\n;\t\nJapatti\tet\nal,\t2013\n).\tMany\tother\tfunctions\tof\tvitamin\tC\tare\tcompromised\tbecause\tof\tthis\t“subclinical”\ndeficiency.\tPioneering\tbiochemist\tBruce\tAmes\tproposed\tthat\tthere\tshould\tbe\ttwo\tcategories\tof\nnutrients\taccording\tto\ttheir\tessentiality\tfor\timmediate\ts... | [
-0.048835720866918564,
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0.059019602835178375,
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0.025613073259592056,
0.05340782552957535,
0.029335053637623787,
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0.06083832308650017,
0.07643447816371918,
-0.10615812242031097,
0.026833530515432358,
0.04... |
reproduction\t(survival-nutrients),\nand\tnutrients\tthat\tfunction\tin\tlong-term\thealth\t(longevity-nutrients)\t(\nAmes,\t2018\n).\nNutrient-partner\tprinciple\nNutrient\tbalance\tis\tthe\tfoundation\tof\tnutrition\tscience,\tand\tthis\tconcept\tis\texpanding\tto\tappreciate\nthe\tprinciple\tthat,\tin\taddition\tto\... | [
-0.060506898909807205,
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0.013189315795898438,
0.041444312781095505,
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0.08659183233976364,
0.0477929450571537,
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0.02246241457760334,
0.1570780873298645,
-0.08392112702131271,
0.021568967029452324,
-0.0261... |
nutrients\tinvolved\tin\tan\tindividual’s\tnutrition\tand\n\tinflammatory\tstatus.\tAn\texample\tof\tapplication\tof\nthe\t\nnutrient-partner\tprinciple\n\tis\tthe\tcommon\trecommendation\tfor\tadults\tto\ttake\tcalcium\nsupplements\talong\twith\tvitamin\tD.\tAnother\texample\tis\tcalcium\tand\tmagnesium.\tFor\tyears,\... | [
-0.017739372327923775,
-0.04901445284485817,
0.04836076498031616,
0.0435405969619751,
-0.04731540009379387,
0.044372379779815674,
0.13931332528591156,
-0.020252926275134087,
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0.026537680998444557,
0.0843852236866951,
-0.07813511788845062,
0.009441053494811058,
0.00095... |
attempt\twas\tmade\tto\troutinely\tassess\tan\tindividual’s\tintake\tof\tmagnesium,\teven\tthough\tthe\tNational\nHealth\tand\tNutrition\tExamination\tSurvey\t(NHANES)\tstudies\tshowed\tthat\t70%\n\tto\t80%\tof\tthe\tU.S.\npopulation\thad\tmagnesium\tintakes\tbelow\tthe\trecommended\tdaily\tallowance\t(RDA).\tWith\trec... | [
-0.013369196094572544,
0.0005476538790389895,
0.0421285443007946,
-0.04060656949877739,
-0.09631551057100296,
-0.024592585861682892,
0.07034894824028015,
-0.007261786609888077,
-0.037648748606443405,
0.03393930569291115,
0.08575364947319031,
-0.06021576374769211,
0.014071366749703884,
0.02... |
recognition\tof\tthis\tcalcium-magnesium\tpartnership,\tmany\tcalcium\tsupplements\tnow\tcontain\nmagnesium\tin\ta\t2:1\tor\t1:1\tCa:Mg\tratio,\tand\tnutrition\tguidelines\tinclude\tthe\tconsumption\tof\tmore\nvegetables\tand\tgreens\tcontaining\tmagnesium\tand\tcalcium.\tThe\tprinciple\tof\tnutrients\tas\twell\tas\nme... | [
-0.05497002601623535,
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0.054445404559373856,
0.0014629267388954759,
-0.10001397132873535,
-0.008271518163383007,
0.09393540769815445,
-0.020731287077069283,
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0.02227448858320713,
0.07463403791189194,
-0.059676434844732285,
0.055180154740810394,
0.0... |
metabolic\n\tsystems\thaving\tsynergistic\trelationships\tare\tseen\tin\t\nBox\t7.1\n.\nBOX\t7.1\nNutrient\tand\tSystem\tPartner\tPrinciples\nNutrient\tpartners\n•\t\nCalcium\t–\tZinc\t–\tCopper\n•\t\nOmega\t6\tGLA/DGLA\t–\tArachidonic\tAcid\t–\tOmega\t3\tEPA/DHA\n•\t\nSodium\tchloride\t–\tpotassium\t–\tcalcium\n•\t\nB... | [
-0.0859600156545639,
-0.09163162857294083,
-0.033351246267557144,
0.03938157483935356,
-0.044899266213178635,
0.035017985850572586,
0.0019746790640056133,
0.07415099442005157,
-0.028127020224928856,
-0.018617477267980576,
0.059991467744112015,
-0.045076675713062286,
-0.017155829817056656,
... |
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