Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11672142
The spectrum is for a high-spin Fe(III) (S = 5/2) complex comparable to the Fe(deferasirox)2 spectrum we previously collected, indicating Fe(III) coordination to the ONO atoms of the deferasirox moiety with meridional arrangement of the DNT ligands (Figure 1A).
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PMC11352746
By using patient-derived neuronal cultures and live-cell imaging to screen for drug responses, researchers can develop tailored therapeutic strategies for individual patients.
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PMC6600592
m.p.
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PMC10994876
This transfected cell group served as a Mock control for comparison purposes.
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PMC9688728
HepG2 cell line (human hepatoblastoma, SCC249) was purchased from Merck, Darmstadt, Germany.
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PMC10507284
Statistical tests: Student's t‐test. (
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PMC7189327
In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was undertaken using KOBAS (http://kobas.cbi.pku.edu.cn/index.php), which is a web-accessible tool and could identify enriched pathways for an input set of genes by mapping to genes using known pathways in the KEGG database .
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PMC9429973
Clinical information of these patients was collected, and their survival station was followed up to analyze the connection between CD200 and 1-year overall survival (OS) rate.
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PMC11190538
The encapsulation process using phytosomes gave it high stability against environmental influences, and therefore, it can be applied in the food and pharmaceutical industries in the future.
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PMC9341513
Box plot showing the distributions of the volume of the probe covering CCND1 in the three cell lines (see text and Supplemental Methods for details).
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PMC11725127
Two equally amounts of supernatants were incubated with biotin or biotin–GA for 1 h at room temperature.
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PMC9429973
This suggests that HexaBody-CD38 is capable of inducing CDC of CD38 myeloma cells in patients who have received prior anti-CD38 mAb treatment with residual daratumumab or isatuximab present in their circulation.
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PMC9878278
The BMP6 can also signal through a non-canonical pathway that involves PI3K-AKT kinases, TRAFs, and JNK/ERK MAP kinases.
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PMC7823217
These bioprinted platforms should also be adapted accordingly for high throughput screening of chemotherapy and other anti-cancer agents by taking into the account the ease of use and the cost.
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PMC9621239
G-K) All clones of the HBV X gene isolated from patients 4, 11, 12, 13 and 23 were genotyped using the phylogenetic trees.
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PMC6312945
In this experiment, the expression of miR-101 and miR-345 in MHCC97-L cells were regulated by the construction of pSUPER.neo-miR-101 and pSUPER.neo-miR-345 expression vectors.
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PMC11290772
In addition to analyzing the purity, we also assessed the functional characteristics of the primary NK cells.
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PMC3765139
CD133+ and CD133- D10 cells were sorted using a FACSVantage® Cell Sorter for genome-wide gene expression profiling.
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PMC11720107
In the CACO-2 cell line, extracts from the Ornak, Violeta, and Morado cultivars reduced LC3A protein expression by 36.63 pg/mL, 111.2 pg/mL, and 85.4 pg/mL, respectively, compared with the control (Figure 7B).
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PMC10956161
Spearman’s correlation coefficient analysis between the levels of expression of the peroxiredoxin 6 (PRDX6) gene and 20 major genes in lung adenocarcinoma.
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PMC11545868
Therefore, researchers have targeted it to destabilize mutations in P53 and induce cancer cell death .
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PMC11758416
Plate ∼1E5 L cells per T75 flask.
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PMC11551844
AuNPs-JC-2 showed more activity than JC-2 on cancer cells A172 and TERA1 (Fig. 4B and C).
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PMC9429973
The Fc portion of ISB 1442 is engineered to enhance antibody dependent cell phagocytosis (ADCP), antibody dependent cell cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).
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PMC11075223
The Cimicifuga plant is a perennial herb.
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PMC11397654
More specifically, the covalently linked calix[n]arene derivatives are described in Section 2, while the calix[n]arene-based complexes are presented in Section 3.
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PMC11228511
Images of the nuclear lamin meshwork at the upper surface of the nucleus (above the middle of the nucleus) were collected by high-resolution confocal fluorescence microscopy (Fig. 1B).
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PMC11401350
All stainings were detected using a MACSQuant flow cytometer (Miltenyi Biotec, Paris, France).
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PMC11721587
Phosphorylation-dependent SUMOylation at IPS1/2 is essential for Ulk3-HA to promote Gli2 phosphorylation and Gli1 expression in NIH3T3 cells treated with Shh (Fig. 6, E and F, and fig. S6, G and H), with IPS2 playing a more critical role than IPS1.
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PMC11411131
MeHg exposure resulted in a 1.7-fold increase in luciferase activity compared with that in the untreated group.
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PMC9429973
Gene usage, % identity to the germline and stereotype subsets were compared with the results obtained from Next-CLL.
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PMC7823217
with Creative Commons Attribution license (CC-BY).
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PMC10142392
The hydrophobic PCL block formed the core, while the hydrophilic poly(quaternary ammonium salt) blocks served as the shell of the micelle.
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PMC9105697
The DNA was eluted in a volume of 200 µL RNase-free water.
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PMC9429973
Transfusion independence within the 8 weeks prior to diagnosis (TI8) was reported for 48% of eligible patients and 17% had intermediate-1/ intermediate disease risk by IPSS/IPSS-R risk classification.
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PMC9504875
Viruses have evolved various strategies to evade the host innate immune system.
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PMC8777939
It is estimated that over 295,000 new diagnoses of ovarian cancer and over 184,799 associated deaths occur worldwide annually .
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PMC10882807
Importantly, the expression of hsa_circ_0005397 was downregulated when depletion of EIF4A3, showing that the RBP protein EIF4A3 may affect the transcription level of hsa_circ_0005397.
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PMC11519567
B Representative images of immunofluorescence in the BJ fibroblasts with lentiviral co-expression of SS18-SSX1-mCherry and SS18-EGFP.
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PMC10809689
Nowadays, it seems essential more than ever to perform in-vivo, preclinical, and clinical studies in the field of using combinational therapies that target both immunological and metabolic pathways, for example, TIM-3 and glutamine metabolism pathway in hematological malignancies such as AML.
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PMC11783017
In the transwell system, Mn and cisplatin inhibited the viability of 143B cells, subsequently reducing the secretion of pro-tumorigenic cytokines CCL2 and IL13 by these cells .
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PMC9503669
The two Nef BiFC fusion constructs were then co-expressed in 293T cells, where Nef homodimer formation resulted in juxtaposition of the YFP fragments and reconstitution of the fluorophore, producing bright green fluorescence at the cell membrane.
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PMC11721587
Limited proteolysis was carried out by mixing samples with trypsin (0.5 μg/ml) at 37°C; a small aliquot was withdrawn at each time point, and protease was inactivated by adding SDS loading buffer.
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PMC7582629
It also requires very low light intensity, thus rendering the approach free from phototoxicity.
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PMC11537649
These findings indicated that Lnc NEAT1 promoted cell migration and invasion in melanoma via the miR-152-3p/CDK6 axis.
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PMC11547972
The tumor suppressor p27 was only upregulated in A498 cells.
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PMC11589157
High-quality mapped reads were used to create a pairs-file with pairtools, which categorized pairs based on insert distance and read types.
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PMC11063646
ANG 1–ANG 11) refer to emulgels prepared with 0.9% Andrographolide along with respective amounts of Xanthan gum, Flax seed oil and other excipients.
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PMC10667689
A similar result was observed in the HL-60 cell line (B, D, F).
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PMC11658074
To verify how AT-EVs exert their effects, NIH3T3 cells with low expression of AdipoR were constructed using the lentivirus, with details provided in the supplementary information.
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PMC11495567
An indirect and somewhat more successful approach to deal with the RAS conundrum was the development of kinase inhibitors targeting the downstream mediators of RAS signaling, RAF, MEK1/2 and ERK1/2 .
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PMC11185260
Human ATRT (BT-12 and CHLA-06) and rhabdomyosarcoma (A-204 and Hs729) were plated at 3.0×10 cells/well in 96-well plates and 24h later treated with either scL-SMARCB1, scL-vec, or scL nanocomplex without payload at various concentrations in triplicates (0–250ng DNA/well).
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PMC4695073
However, the results showed that eIF3a expression isn't significantly correlative with either XPA level or patients' survival (data not shown).
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PMC9250505
When xenografts reached 150–200 m, the mice were randomized into the four indicated treatment groups (n = 6).
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PMC10975211
In their study, Lee et al. (2008) employed an NCI-H460 lung cancer cell line utilizing a transplantation technique to generate tumor xenografts.
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PMC11482552
Nevertheless, an appropriate IC molecular assay cut-off needs to be established in order to appropriately assess the sample adequacy.
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PMC10998613
A Kozak consensus sequence was added by inserting ACC at position −3 and G at position +4 from the starting codon.
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PMC11759751
Flow cytometry, along with absolute counting beads, was used to determine the number of viable tumor cells remaining after co-culture.
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PMC8956657
Empty vector (E) served as a control and samples were treated with TNFα as indicated.
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PMC11739484
MMP11 expression exhibited positive associations with “angiogenesis, differentiation, and inflammation” (Fig. 9B).
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PMC8633974
Transmission electron micrographs of single- or dual-tat mutants are illustrated, confirming viral particle formation similar to wild-type viruses.
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PMC11766174
Among the factors contributing to the sensitivity of CA-ICC is the use of a combination of two mAbs that bind to different epitopes in CA to minimize the detection of false negatives.
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PMC11678130
This method is described in a previous study .
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PMC11394112
U2932 cells harbor extensive BCL2 amplification and mutated CD79B, while VAL cells are positive for BCL2, BCL6, and MYC translocations and CREBBP mutations, all of which are associated with poor patient outcomes .
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PMC10631132
GMPs are capable of giving rise to CD11b and CD14 monocytes which are well known to be able to differentiate into OCs [71–75].
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PMC9822769
H, N] HSQC spectra were recorded at 300 K on a Bruker Avance III NMR spectrometer operating at 500 MHz (H) with the standard Bruker sequence hsqcetgpsiz (0.2 s acquisition time, 8 scans, 1.3 s relaxation delay, and 128 F1 points) .
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PMC11531744
The survival difference between these subgroups was measured using Kaplan-Meier survival method.
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PMC6450504
The relative area of selection was kept constant among different spheroids.
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PMC11711345
Moreover, the ADMET properties were predicted using three servers.
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PMC9429973
Pts over 60yo were more likely to have a dose modification than pts below 60yo (73% vs 43% p = 0.014).
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PMC9429973
The findings of this review highlight the significant unmet need for this very difficult-to-treat population.
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PMC11683240
α1AT, α1-antitrypsin; Gαi, α-subunit of inhibitory G protein; PT, pertussis toxin.
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PMC11377827
Representative of three biological replicates. (
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PMC11638255
d Representative images of merged OPAL multiplex immunofluorescence spectra depicting the tumoral distribution of NCR1 natural killer cells (red), CD8 cytotoxic T cells (yellow), CD11b myeloid (white) and DAPI nuclei stain (blue) in Th-MYCN neuroblastoma tumor tissue 14 days post-treatment.
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PMC11707577
The only supracellular structure still present 24 h after the treatment was the inner compartment of the spheroid, usually described as the necrotic core.
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PMC11394386
In a study involving 89 patients, HOTAIR was found to be significantly overexpressed (ΔCt value: 5.74 ± 1.129 versus 8.22 ± 1.301, p < 0.001), underlining its potential utility as a clinical biomarker .
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PMC9454178
E Gene expression profile in the MediSapiens IST Online transcriptome database.
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PMC9429973
Five other frequent subtypes (CRLF2, hypodiploid, hyperdiploid, PAX5 alterations and Ph-positive) were distinguishable in 40% of patients, although overlapping transcriptional profiles led to lower accuracy (52% ≤ PPV ≤ 73%).
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PMC11794847
After the addition of PMA and ionomycin, cells were incubated under standard culture conditions.
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PMC10996034
ZYX is an adhesion protein that affects cell adhesion and cytoskeletal rearrangement, leading to cell proliferation and migration (42,43).
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PMC11674834
DNA and the γH2AX were simultaneously visualized using an Odyssey CLx imaging system (LI-COR, Lincoln, NE, USA) with the 680 nm fluorophore (red) and the 800 nm fluorophore (green).
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PMC11240448
Along with mTOR, the MEK/ERK pathway and the STAT3 pathway are critical in activating the DPDonc module in ten and six luminal cell lines, respectively (SI file cSTAR_networks.zip).
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PMC11615828
The normalized mean speed of the indicated vesicles upon rapamycin treatment is shown.
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PMC11052306
Dendrons having a Boc-protected amine at the core (dendrons 6a,b,c-G1) were tentatively deprotected to generate a primary amine suitable to react with GO modified with acyl chlorides.
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PMC9429973
In the present study we developed a screening assay using a clinically relevant viral vector while simultaneously maintaining genomic context and cell type relevance.
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PMC8358006
All of the cells were authenticated by short tandem repeat analysis and regularly tested for mycoplasma contamination.
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PMC11468365
Then, DeepDSC employed a deep learning model to predict synergistic drug combinations.
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PMC11665584
Comparatively, the hyperplastic interfollicular epidermis mirrored the much thicker epithelium of the buccal mucosa (Figure 1B).
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PMC8984067
Then, samples were observed and detected using an external 980 nm light source under an inverted fluorescence microscope.
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PMC11407042
CRITICAL: Do not pipette up and down while transferring.
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PMC9429973
dPCR was carried out in DNA and ccfDNA samples, using specific primers and probes for FMC63 and a reference gene.
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PMC11711127
Effector T cells carry out specific activities in response to antigenic stimulation and play a key role in steering the immune responses to execute immune functions.
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PMC11138140
This pre-plating step was conducted at 37 °C in a 5% CO2 incubator for 1 to 2 h to deplete non-cardiomyocyte populations through selective attachment.
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PMC11725127
Data are mean ± SD (n = 3), P-values were analyzed by two-way ANOVA (H, J).
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PMC11615828
The enlarged mean speed trajectories of VAMP2‐positive vesicles are shown.
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PMC11599565
The formation of neuronal structures reminiscent of multipolar neurons is clearly analogous to normal neuron development observed in brain cells isolated from rats (Panel A).
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PMC11190062
Multiple myeloma (MM) is a plasma cell cancer characterized by the accumulation of clonal plasma cells in the bone marrow.
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PMC11740907
We allowed the slides to dry completely after rinsing them with methanol.
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PMC11320834
CI < 1 indicates a synergistic effect, and CI = 1 indicates an additive effect.
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PMC10213199
Table 3GroupDownUpTotalLow conc.
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