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OTAR3088
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PMC10547921
Considering Bcl-xL as a target of payloads of ADC drugs may retain the activity of Bcl-xL inhibitors while reducing their toxicity to platelets.
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PMC6600253
Previous studies have demonstrated that senescence occurs in different tumor tissues, where it attenuates tumor development and progression.
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PMC9784246
The receptor’s active sites for ligand binding were determined based on amino acid residues interacting with the complexed ligand for each protein.
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PMC11277157
Notably, many of the genes were strongly induced (>10-fold).
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PMC7724160
To maximize metabolite detection, we chose to analyze the metabolites in each sample using multiple methods, namely, NMR, RP-LC/MS, and HILIC/MS.
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PMC9429973
Aims: Aim of the study is to test the hypothesis of chemotherapy-induced endothelial damage (CIED), increased microvascular perfusion and reduced metabolism in response to pressure-adjusted static compression (PSC) in patients undergoing chemotherapy (CTX) with and without CIPN.
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PMC11487720
These findings represent a significant step forward in our understanding of cell death under extreme conditions.
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PMC11721277
The RHT level was measured using system B (Tc colloid stayed at the application point, Rf = 0.0, other forms of Tc ions and Tc-labeled HYNIC-Chl, and Rf = 1.0).
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PMC9429973
A. Coelho, P. Moura, I. Santos, P. Martins, J. Carda, A. B. Sarmento-Ribeiro Faculty of Medicine, University of Coimbra; Clinical Hematology Department; Intensive Care Unit, Centro Hospitalar e Universitário de Coimbra; Laboratory of Oncobiology and Hematology and University Clinic of Hematology; Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO); Center for Innovative Biomedicine and Biotechnology; Institute of Physiology; Clinical Academic Center of Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal Background: Patients with COVID-19 have a higher incidence of thromboembolic events (TE) probably due to endothelial injury caused by the binding of SARS-CoV-2 to the ACE-2 receptors.
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PMC5415764
The apoptosis-related protein expression results indicated that to co-delivery of PTX and TET in iRGD peptide decorated NPs may be a more effective strategy to overcome MDR in ovarian cancer.
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PMC11798926
A follow-up proteomics study did report select enrichment of SynDIG4 with GluA1 over GluA2 (Schwenk et al., 2014), consistent with the cryo-EM study.
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PMC11637276
For α2 integrin staining, cells were incubated with FITC anti-human CD49b antibody (1:200 dilution) in PBS.
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PMC11748363
The influence of the position of Cl on the pyridine ring was most apparent when R is 4‐Cl.
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PMC11402217
Moreover, XD23 markedly impedes OS cell migration, invasion, and EMT, contributing to reduced lung metastasis in vivo.
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PMC11700165
ITK-SYK induced stronger IL-3-independent proliferation, suggesting that BTK-SYK might be less oncogenic even in a B cell setting.
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PMC10440586
Therefore, we suspected CD99 is associated with adaptive responses to hypoxia in glioma.
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PMC11787651
The TOF MS scan range was m/z 120 to 1400.
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PMC11512230
Overlaid channels were analyzed using the ImageJ (software version 1.53e, National Institutes of Health, Stapleton, NY, USA) software to count the total number of cells (ni) and the number of cells, which adsorbed FITC-labeled SP (xi).
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PMC8524093
IFN production is induced after the activation of pattern recognition receptors (PRRs), a group of membrane-associated or intracellular receptors that recognize exogenous molecules, including viral RNA.
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PMC8998437
While some BL cell lines retain their original BL tumor cell phenotype and EBV latency I, many EBV-carrying BL cell lines shifted toward a lymphoblastoid phenotype during establishing of the culture in vitro, in the absence of the immune control, and obtained a so-called group III growth phenotype.
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PMC11777207
Experimental scheme.
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PMC8041314
However, small-molecule inhibitors to target ABC transporters are only known for a fraction of these 49 transporters.
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PMC11518702
For *U2932 DLBCL cells, HGAL expression decreased tumor mass and increased survival relative to *U2932 controls ( Figure 1E ).
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PMC9844987
As highly multimodal peaks are mainly found to be associated with low variable promoters, we hypothesized that this flexibility in core promoter usage may act as a compensatory mechanism to stabilize their expression.
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PMC6379402
Twenty-four hour later, the transfection mix was replaced with fresh media.
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PMC11247842
Squares on the outside of the circle are sorted by tissue for each GWAS significance threshold for 1, 0.1, 0.01, 1, 1 and 3.16 (shown by inner colours and bottom legend) Enrichment analysis.
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PMC4659567
The Ru(II) atom of 6 is η -π-bonded to the arene ring of p-cymene, and coordinated by two chlorido ligands and one 2Me4Claza molecule monodentate-coordinated to the metal centre through the pyridyl nitrogen (N7).
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PMC11089031
The knockdown of ZNF692 inhibited the proliferation and migration of ccRCC cells by target GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2), and transmembrane 9 superfamily member 2 (TM9SF2)).
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PMC9429973
Following the completion of first-line ICT, ALC normalization was observed in 43 patients (58%).
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PMC11730311
Lipidation of hαCGRP8-37 at all positions were associated with loss of potency on the hCGRP-R (Fig. 1).
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PMC11750712
CAR T cells (orange) are identified by coexpression of both Q/BenD10 and anti-CD3.
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PMC10728200
B Body weight was measured every 3 days until day 18.
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PMC10024132
Cell lines were grown at 37°C in a humidified incubator with 5% CO2.
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PMC9712534
In this study, we analyzed the nuclear dynamics of TOP2B with H58Y (TOP2B H58Y).
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PMC11588008
On the next day, HRP-labeled rabbit secondary antibody was added to the membranes and incubated for 1 h. Finally, it was developed and analyzed by a Western blot developer.
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PMC11538390
GWAS of 151 cases with CL/P did not yield any genome-wide significant hits (Supplementary Fig. 1b).
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PMC11063646
Compared to untreated cells (0.54 % uptake) the ANG-12 treated cells had shown 87.17 % FITC permeation.
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PMC11401350
In vivo gene therapy with the CD8-retargeted LVs encoding for a CAR, might result in a huge benefit in terms of costs.
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PMC11365983
Box-whisker plots show quartiles, median (black lines) and mean (black dots) values.
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PMC9429973
Decline in best corrected visual acuity (BCVA) by at least 2 lines occurred in 8 patients (Gr 3 n=6, Gr 2 n=2).
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PMC11742670
SMILES notation is valuable for computer-based analysis and the study of chemical properties.
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PMC10218459
After exposure to cytostatic drugs, the cells were incubated with CellTiter-Blue reagent for 2 h. Cells exposed to argon and cytostatic drugs served as controls.
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PMC11796104
Using 35 clinical samples, three potential circRNAs and three miRNAs associated with male osteoporosis were selected for validation.
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PMC11185260
More importantly, there was a significant increase in survival when scL-SMARCB1 was combined with radiation (Figure 7C).
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PMC9878562
Together the observations indicate a synergistic effect of LTB4 on CXCR4/CXCL12- mediated VAL cell migration in vitro ( Figure 6B ).
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PMC4443654
However, these two boundary classes occur at different scales, with patterns of informative features typically spanning regions up to 500 kb for TAD boundaries, and patterns associated with compartment boundaries often spanning more than 1 Mb (Additional file 1: Figure S12, Additional file 1: Figure S13).
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PMC9429973
The KM rate of achieving TI at 3 months was 45.0% in the VEN cohort and 35.9% in the control cohort (log-rank p=0.12).
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PMC11754291
This figure was illustrated with BioRender.
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PMC11696659
The main hurdle for biomarker development is the need for resource intensive, long term, longitudinal studies to demonstrate clinical utility.
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PMC9503541
All cells were grown in at least three biological replicates and maintained in a humidified atmosphere with 5% CO2 at 37 °C.
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PMC7351993
The details of the fabrication process are described in our previous report.
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PMC9429973
Thirty two days after HSCT, patient relapsed with 60% BM blasts detected by flow cytometry.
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PMC11106977
Umar et al. found that Penta-o-galloyl-beta-d-Glucose (PGG) could inhibit O-GlcNAcylation of transforming growth factor beta-activated kinase 1-binding protein 1 (TAB1) and reduce TGF-β-activated kinase 1 (TAK1) activation in IL-1β-stimulated human RA synovial fibroblasts (RASFs).
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PMC11787651
Adapting this method, we tested microflow gradients including 5 to 32% B in 10 min followed by an increase to 45% B in 4 min, a 10-min linear gradient from 5 to 32% B, and a 10-min linear gradient from 5 to 45% B, and a 5-min linear gradient from 5 to 30% B. Flow rates of 5 μl/min and 10 μl/min were compared for the various gradients, and column washing and equilibration were optimized to minimize total run time without sacrificing robust and reproducible chromatography.
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PMC6034753
We also used immunofluorescence assay to examine whether apoptin co-localised with the endogenously expressed Meq in MSB-1 cells.
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PMC8996378
This review discusses the research progress on diterpenoids in reversing MDR.
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PMC11684297
Post centrifugation, an image was captured in a camera, and the supernatant was gently aspirated out in fresh tubes to record the absorbance at 541 nm (the absorption maxima of hemoglobin).
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PMC11085211
The extract (AUN) was suspended in 700 mL of water and subjected to liquid/liquid partition using in-series chloroform (CHCl3) or ethyl acetate (EtOAc).
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PMC11243198
Compounds with activity in only one readout (flu or abs) were excluded to eliminate those potentially interfering with the assay , resulting in six compounds being selected for further analysis.
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PMC11476222
Utilizing these R scripts significantly reduced data processing time.
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PMC6643347
The neutralization analysis was performed using TZM-bl cells according to the Montefiori method , which is a modified version of the analysis by Wei et al. .
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PMC11394386
The mechanisms underlying the sustained activation of the PI3K/AKT and Wnt/β-catenin pathways mediated by HOTAIR in cervical cancer (CC) have not been extensively described.
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PMC11656657
Our preclinical data strongly suggest that CAR.GD2 T-cells hold promise as a potential therapeutic option for the treatment of patients with GD2-positive sarcomas.
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PMC11575040
A, B Analysis of cell cycle distribution in A2058 cells with LINC00094 knockdown for 72 h. C, D Analysis of cell cycle distribution in A375 cells with LINC00094 knockdown for 72 h. E, G Evaluation of apoptosis in A2058 and A375 cells after LINC00094 knockdown for 24, 48, and 72 h. F, H Quantification of the percentage of apoptotic cells To determine whether LINC00094 is expressed in the cytoplasm or nucleus, nuclear and cytoplasmic RNA extraction was conducted to isolate nuclear and cytoplasmic RNA, and real-time PCR was employed to confirm the expression levels.
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PMC9429973
At time of last follow-up, there were 623 deaths (25.4%).
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PMC9261184
If there is insufficient demand for BOG from the engines, BOG can either be sent to a reliquefaction facility and sent back to the storage tanks or combusted (flared) in the gas combustion unit (GCU).
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PMC11409031
4Construct a clinical prognosis model and evaluate it using machine learning algorithms. (
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PMC11297139
Collectively, our findings demonstrate that ARID1A promotes oncogenic potential through PrLD-mediated LLPS, offering a potential therapeutic approach for treating Ewing’s sarcoma.
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PMC11448304
Meanwhile, enrichment analysis were also performed on the data (Fig. 2d, Supplementary Fig. 1b, c, d).
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PMC11468365
Drug combination treatments have proven to be a realistic technique for treating challenging diseases such as cancer by enhancing efficacy and mitigating side effects.
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PMC11756514
As also covered in a recent study by Lehmann et al. (58)there is an interplay between CP and WTA during S. aureus infection, which is a delicate balance between immune evasion and colonization.
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PMC11802929
Differentially expressed genes were called via scanpy.tl.rank_genes_groups through the Scanpy package using the Wilcoxon method which implements the Mann-Whitney U test.
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PMC11731161
Inherent and acquired resistance present a significant challenge.
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PMC11791203
Mishma et al.. also highlighted the anticancer properties of 2,4-di-tert-butylphenol in brain cancer, emphasizing its effectiveness as a drug candidate.
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PMC11001582
Anesthetic depth was confirmed by monitoring pedal reflex and breathing rate.
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PMC11530949
Regarding cancer treatment, organic nanomaterials such as liposomes, polymers, dendrimers, and peptides have been extensively employed for the synthesis of NPs in medical applications due to their compatibility with living tissues (12-14).
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PMC5833712
Tubulin was used as loading control a Percentage of growth inhibition in A2780cis cells after 24-h treatment with different doses of cisplatin, in the range of 1 to 80 μM alone or in combination with 10 nM of KB9520 or PPT.
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PMC6889484
Because of this, A3G-D128K expression in HIV-1 target cells is a potential anti-HIV gene therapy approach that could be combined with other therapies for the treatment and functional cure of HIV-1 infection.
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PMC10705095
Collectively, our results demonstrate that targeting HBQ1 provides a new therapeutic approach for lung adenocarcinoma treatment.
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PMC11055323
Data are mean ± s.d.,
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PMC11365983
Representative images of Arl13b/γ-tubulin staining in primary meningeal cell cultures from Foxc1Tg(EIIa-cre) and wild-type sibling E15.5 embryos.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "Arl13b/γ-tubulin", "staining", "in", "primary", "meningeal", "cell", "cultures", "from", "Foxc1Tg(EIIa-cre", ")", "and", "wild-type", "sibling", "E15.5", "embryos", "." ] } ]
PMC11171319
Similar to oncoviruses, HCMV infection leads to an immune-tolerant environment that will favor tumor appearance, growth, and spread parallel to increased viral fitness .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "oncoviruses", ",", "HCMV", "infection", "leads", "to", "an", "immune-tolerant", "environment", "that", "will", "favor", "tumor", "appearance", ",", "growth", ",", "and", "spread", "parallel", "to", "increased", "viral", "fitness", "." ] } ]
PMC11742290
CSCs have unique ability to self-renew and differentiate, forming diverse cell populations within tumors.
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PMC11055323
Mice were randomized into two groups (n = 4) once tumor volume reached approximately 100 mm (V = L × W/2): vehicle (10% DMSO (Sigma-Aldrich, D2650) + 40% PEG300 (MedChemExpress, HY-Y0873) + 5% Tween 80 (MedChemExpress, HY-Y1891) + 45% saline) or A-485 (100 mg/kg/dose, 2 dose/day) by intraperitoneal injection.
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PMC11377827
Quantification of USP43 associated with immunoprecipitated 14-3-3 (C).
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PMC11534035
CAL39 VSCC cell lines treated with G36 display heightened migration capability.
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PMC11281366
Using the virion capture-assay described above, we also confirmed that cells treated with miRNA-26a mimics produced approximately 50% less CD59-containing virions than their control-treated counterparts (~2-fold less, p = 0.0079), suggesting that the downregulation of CD59 expression by miRNA-26a leads to the reduced packaging of the protein into released virions (Figure 6B).
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PMC11737091
Forrest plot of the multivariate Cox regression analysis for ccRCC. *,
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PMC9429973
Moreover, granulocytes from MF patients display higher level of IR-ligands transcripts hinting an immunosuppressive interplay between the myeloid neoplastic clone and T cells.
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PMC11736898
The current study was undertaken to investigate derangements in vitamin D signaling in keloid-derived keratinocytes.
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PMC11509309
Proteins were then transferred to a 0.45 μm nitrocellulose membrane (GE Healthcare, Chicago, IL, USA, #10600002) for 1 h at 0.5 A in transfer buffer (25 mM Tris-HCl pH 8.3, 192 mM glycine, 20% ethanol, 0.1% SDS).
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PMC8956657
Error bars represent the mean values ± standard deviation for triplicate experiments.
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PMC9429973
Three out of these patients developed thrombosis (3.5%).
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PMC8913139
Therefore, the regulatory mechanism of miR-448 in the development of GBM is elucidated in this study.
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PMC8068766
To construct meaningful trees, β, ω, and µ input parameters must be chosen correctly, and for each DEG list, the optimum values of those input parameters were determined separately by the Forest-tuner algorithmhttps://github.com/gungorbudak/forest-tuner accessed on 25.06.2020 to generate trees with higher number of prices and smallest mean degrees of nodes.
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PMC7215722
Moreover, cytokines such as interferon γ and tumor necrosis factor α (TNF α,) play an important role in the maintenance of barrier function , and several studies have shown that they can be responsible for the disruption of the monolayer .
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PMC11687663
Furthermore, a strong-intensity absorption peak at 1054 cm confirms the presence of ester (C-O, stretching) functional group.
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PMC11697703
Figure 4miR-193b and miR-365 gain-of-function decreases dendritic complexity in superficial-layer neurons(A) Experimental approach for miRs loss-of-function (LoF) and gain-of-function (GoF) in deep-layer neuron cultures.(B and C) Analysis of neurite branching by Sholl analysis after miR-193b GoF and LoF (B), and after miR-365 193b GoF and LoF. ANOVA-Tukey, p values are presented as follows; ∗p < 0.05, ∗∗p < 0.01 (n = 3 per condition).(D) Experimental approach for in vivo miRs GoF in superficial-layer neurons.(E) Representative image of the electroporated area analyzed in all conditions (Elect-S1).(F–J′) Images of electroporated neurons for each condition: single miR-scramble sequence (miR-Cnt) (F and F′), miR-365 (G and G′), miR-193b (H and H′), co-electroporation of miR-scramble sequences of miR-193b and miR-365 (miR-Cnt-double) (I and I′), and co-electroporation of miR-193b-miR-365 (J and J′).
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PMC11457557
In the past, studies looking for genetic risk factors for diabetes complications relied on methods such as candidate gene studies, which were rife with false positives, and underpowered genome-wide association studies, which were constrained by small sample sizes.
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PMC3019555
RNA isolation after GFP immunoprecipitation was performed as described previously (Tenenbaum et al., 2002).
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