OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	There were 17/24 (70.8%) patients who completed 3 cycles: 3 showed CR; 2 showed VGPR; 11 showed PR and 7 with progressive disease as shown in the Figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "17/24", "(", "70.8", "%", ")", "patients", "who", "completed", "3", "cycles", ":", "3", "showed", "CR", ";", "2", "showed", "VGPR", ";", "11", "showed", "PR", "and", "7", "with", "progressive", "disease", "as", "shown", "in", "the", "Figure", "." ] } ]
PMC11790971	Mann–Whitney U tests were employed to compare the feature values of different cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mann", "–", "Whitney", "U", "tests", "were", "employed", "to", "compare", "the", "feature", "values", "of", "different", "cell", "lines", "." ] } ]
PMC11499955	Surprisingly, the amount of TMPP-H15 was also significantly high.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surprisingly", ",", "the", "amount", "of", "TMPP-H15", "was", "also", "significantly", "high", "." ] } ]
PMC9599726	Therefore, the development of novel therapeutic strategies remains essential to improve patient outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "development", "of", "novel", "therapeutic", "strategies", "remains", "essential", "to", "improve", "patient", "outcome", "." ] } ]
PMC7153288	Five gene clusters in Streptomyces sp. SS1-1 showing moderate to high similarities with known gene clusters in Streptomyces species were terpene (with hopene of Streptomyces coelicolor A3(2) with 92% similarity), siderophore (with desferrioxamine B of Streptomyces coelicolor A3(2) with 83% similarity), type 2 polyketide (with spore pigment of Streptomyces avermitilis with 75% similarity), melanin (with melanin of Streptomyces avermitilis with 57% similarity), and type 1 PKS (with hitachimycin of Streptomyces scarisporus with 54% similarity).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Five", "gene", "clusters", "in", "Streptomyces", "sp.", "SS1", "-", "1", "showing", "moderate", "to", "high", "similarities", "with", "known", "gene", "clusters", "in", "Streptomyces", "species", "were", "terpene", "(", "with", "hopene", "of", "Streptomyces", "coelicolor", "A3(2", ")", "with", "92", "%", "similarity", ")", ",", "siderophore", "(", "with", "desferrioxamine", "B", "of", "Streptomyces", "coelicolor", "A3(2", ")", "with", "83", "%", "similarity", ")", ",", "type", "2", "polyketide", "(", "with", "spore", "pigment", "of", "Streptomyces", "avermitilis", "with", "75", "%", "similarity", ")", ",", "melanin", "(", "with", "melanin", "of", "Streptomyces", "avermitilis", "with", "57", "%", "similarity", ")", ",", "and", "type", "1", "PKS", "(", "with", "hitachimycin", "of", "Streptomyces", "scarisporus", "with", "54", "%", "similarity", ")", "." ] } ]
PMC11794588	The ability of lupeol to protect C. elegans from oxidative damage further supports its antioxidant and health-promoting effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", "of", "lupeol", "to", "protect", "C.", "elegans", "from", "oxidative", "damage", "further", "supports", "its", "antioxidant", "and", "health-promoting", "effects", "." ] } ]
PMC7039683	B–D) Surface plots for wild-type embryos at 11 hpf injected at the 1 cell stage with GFP reporter constructs for cldne +3, cldne −11, and cldne −8 elements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "–", "D", ")", "Surface", "plots", "for", "wild-type", "embryos", "at", "11", "hpf", "injected", "at", "the", "1", "cell", "stage", "with", "GFP", "reporter", "constructs", "for", "cldne", "+", "3", ",", "cldne", "−11", ",", "and", "cldne", "−8", "elements", "." ] } ]
PMC11682525	The hHFSCs and SH-SY5Y cells were initially seeded in 96-well plates.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hHFSCs", "and", "SH-SY5Y", "cells", "were", "initially", "seeded", "in", "96-well", "plates", "." ] } ]
PMC11078693	Collect media with floating cells into a 50 mL conical tube.b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collect", "media", "with", "floating", "cells", "into", "a", "50", "mL", "conical", "tube.b", "." ] } ]
PMC9429973	Aims: To estimate prognostic properties of palpable splenomegaly and potential differences between PMF and SMF patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "estimate", "prognostic", "properties", "of", "palpable", "splenomegaly", "and", "potential", "differences", "between", "PMF", "and", "SMF", "patients", "." ] } ]
PMC11474209	WHO Alert Level 1 for cyanobacterial blooms in recreational waters occurs when the chlorophyll-a level exceeds 12 micrograms per litre and cyanobacteria dominate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WHO", "Alert", "Level", "1", "for", "cyanobacterial", "blooms", "in", "recreational", "waters", "occurs", "when", "the", "chlorophyll-a", "level", "exceeds", "12", "micrograms", "per", "litre", "and", "cyanobacteria", "dominate", "." ] } ]
PMC11766350	However, both shRNA samples showed significantly reduced yields per cell compared to the non-TRAIL control 2.07 × 10 vg/cell, p < 0.001, t-test) (Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "both", "shRNA", "samples", "showed", "significantly", "reduced", "yields", "per", "cell", "compared", "to", "the", "non-TRAIL", "control", "2.07", "×", "10", "vg/cell", ",", "p", "<", "0.001", ",", "t-test", ")", "(", "Figure", "S1", ")", "." ] } ]
PMC11754291	These results visually reinforce the differential effects of CM, CMK, and CMiK on melanocyte morphology, pigmentation, and proliferation, highlighting the contribution of irradiated keratinocytes to melanogenesis and cell growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "visually", "reinforce", "the", "differential", "effects", "of", "CM", ",", "CMK", ",", "and", "CMiK", "on", "melanocyte", "morphology", ",", "pigmentation", ",", "and", "proliferation", ",", "highlighting", "the", "contribution", "of", "irradiated", "keratinocytes", "to", "melanogenesis", "and", "cell", "growth", "." ] } ]
PMC11257988	Rat sarcoma (RAS) genes are the most commonly mutated oncogenes in human cancers, with Kirsten rat sarcoma (KRAS) being the most common subtype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rat", "sarcoma", "(", "RAS", ")", "genes", "are", "the", "most", "commonly", "mutated", "oncogenes", "in", "human", "cancers", ",", "with", "Kirsten", "rat", "sarcoma", "(", "KRAS", ")", "being", "the", "most", "common", "subtype", "." ] } ]
PMC10547921	Stephan Rigol has synthesized the thailanstatin analogs 85 and 86, which have the IC50 value of picomoles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stephan", "Rigol", "has", "synthesized", "the", "thailanstatin", "analogs", "85", "and", "86", ",", "which", "have", "the", "IC50", "value", "of", "picomoles", "." ] } ]
PMC8009078	No abnormal variation of the RoG value was found in any of the systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "abnormal", "variation", "of", "the", "RoG", "value", "was", "found", "in", "any", "of", "the", "systems", "." ] } ]
PMC11300085	The intention of study was to investigate the effect of chemerin on biological behaviors of OC cells and reveal the underlying specific mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "intention", "of", "study", "was", "to", "investigate", "the", "effect", "of", "chemerin", "on", "biological", "behaviors", "of", "OC", "cells", "and", "reveal", "the", "underlying", "specific", "mechanism", "." ] } ]
PMC10391797	ANOVA, analysis of variance; AML, acute myeloid leukemia; BMMC, bone marrow mononuclear cells; CAR, chimeric antigen receptor; NKG2D, natural-killer group 2 member; PBMCs, peripheral blood mononuclear cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANOVA", ",", "analysis", "of", "variance", ";", "AML", ",", "acute", "myeloid", "leukemia", ";", "BMMC", ",", "bone", "marrow", "mononuclear", "cells", ";", "CAR", ",", "chimeric", "antigen", "receptor", ";", "NKG2D", ",", "natural-killer", "group", "2", "member", ";", "PBMCs", ",", "peripheral", "blood", "mononuclear", "cells", "." ] } ]
PMC9429973	Results: The detection algorithm achieved high overall accuracy for detecting nucleated cells in microscopy images (sensitivity and precision of 91.6% and 91.3% respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", "detection", "algorithm", "achieved", "high", "overall", "accuracy", "for", "detecting", "nucleated", "cells", "in", "microscopy", "images", "(", "sensitivity", "and", "precision", "of", "91.6", "%", "and", "91.3", "%", "respectively", ")", "." ] } ]
PMC11499381	Normalized curves were generated for presentation by combining the mean of data points from normalized individual experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normalized", "curves", "were", "generated", "for", "presentation", "by", "combining", "the", "mean", "of", "data", "points", "from", "normalized", "individual", "experiments", "." ] } ]
PMC8632470	This Japanese celery could be further explored for its potential as a plant-based nephroprotective drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "Japanese", "celery", "could", "be", "further", "explored", "for", "its", "potential", "as", "a", "plant-based", "nephroprotective", "drug", "." ] } ]
PMC11665555	Both regulators are known as transcriptional repressors of EMT in favor of epithelial differentiation (20, 44).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "regulators", "are", "known", "as", "transcriptional", "repressors", "of", "EMT", "in", "favor", "of", "epithelial", "differentiation", "(", "20", ",", "44", ")", "." ] } ]
PMC9429973	Prognosis of der(1;7) MDS cases tended to be better than -7/del(7q) cases (HR=0.71, p=0.098), but poorer than +1q (HR=1.36, p=0.11) and others cases (HR=1.8, p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prognosis", "of", "der(1;7", ")", "MDS", "cases", "tended", "to", "be", "better", "than", "-7/del(7q", ")", "cases", "(", "HR=0.71", ",", "p=0.098", ")", ",", "but", "poorer", "than", "+", "1q", "(", "HR=1.36", ",", "p=0.11", ")", "and", "others", "cases", "(", "HR=1.8", ",", "p<0.001", ")", "." ] } ]
PMC9019892	Approximately 15 000 new GIST patients are diagnosed annually worldwide .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "15", "000", "new", "GIST", "patients", "are", "diagnosed", "annually", "worldwide", "." ] } ]
PMC9429973	cPCDMT1 is critical for the proliferation of CML-BC through the regulation of DNA replication and may represent a novel target for therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cPCDMT1", "is", "critical", "for", "the", "proliferation", "of", "CML-BC", "through", "the", "regulation", "of", "DNA", "replication", "and", "may", "represent", "a", "novel", "target", "for", "therapy", "." ] } ]
PMC10218459	Another typical feature of ES is the onset in childhood and adolescence, with a peak between the age of 5 and 24 years .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "typical", "feature", "of", "ES", "is", "the", "onset", "in", "childhood", "and", "adolescence", ",", "with", "a", "peak", "between", "the", "age", "of", "5", "and", "24", "years", "." ] } ]
PMC4360730	In addition to the official term name, each term is associated with a range of synonyms that represent alternate phrasings or related concepts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "the", "official", "term", "name", ",", "each", "term", "is", "associated", "with", "a", "range", "of", "synonyms", "that", "represent", "alternate", "phrasings", "or", "related", "concepts", "." ] } ]
PMC11727062	Monomers derived from cold herbal sources exhibit a range of pharmacological effects, including antioxidant, anti-inflammatory, and antimicrobial properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monomers", "derived", "from", "cold", "herbal", "sources", "exhibit", "a", "range", "of", "pharmacological", "effects", ",", "including", "antioxidant", ",", "anti-inflammatory", ",", "and", "antimicrobial", "properties", "." ] } ]
PMC10033453	The following day, cells were treated with either MOI 10 or 1 VMG, poly (I:C) (2 μg/mL) (Innaxon, Tewkesbury, UK) plus Lipofectamine 3000 (2 μL/mL) (Thermo Fisher Scientific), or media-only control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "day", ",", "cells", "were", "treated", "with", "either", "MOI", "10", "or", "1", "VMG", ",", "poly", "(", "I", ":", "C", ")", "(", "2", "μg/mL", ")", "(", "Innaxon", ",", "Tewkesbury", ",", "UK", ")", "plus", "Lipofectamine", "3000", "(", "2", "μL/mL", ")", "(", "Thermo", "Fisher", "Scientific", ")", ",", "or", "media-only", "control", "." ] } ]
PMC10507284	Further differential analysis based on STS tissue data in TCGA and normal tissue data in GTEx also indicates that TROAP is abnormally increased in STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "differential", "analysis", "based", "on", "STS", "tissue", "data", "in", "TCGA", "and", "normal", "tissue", "data", "in", "GTEx", "also", "indicates", "that", "TROAP", "is", "abnormally", "increased", "in", "STS", "." ] } ]
PMC10482220	Arrows indicate transfected cells expressing GFP fusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arrows", "indicate", "transfected", "cells", "expressing", "GFP", "fusions", "." ] } ]
PMC11790599	Actin cytoskeleton, Rac1, and cholesterol are required for macropinosome formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Actin", "cytoskeleton", ",", "Rac1", ",", "and", "cholesterol", "are", "required", "for", "macropinosome", "formation", "." ] } ]
PMC9275501	Some natural active ingredients and chemotherapy drugs can be coupled together via ester bonds or acetal bonds to form carrier-free nano-systems to obtain high drug loading and synergistic antitumor effects, such as PTX and succinic acid (SA) (Xu et al., 2017a), 5-FU and CA (Fang et al., 2021), MTX and ursolic acid (UA) (Figure 8) (Lan et al., 2021a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "natural", "active", "ingredients", "and", "chemotherapy", "drugs", "can", "be", "coupled", "together", "via", "ester", "bonds", "or", "acetal", "bonds", "to", "form", "carrier-free", "nano-systems", "to", "obtain", "high", "drug", "loading", "and", "synergistic", "antitumor", "effects", ",", "such", "as", "PTX", "and", "succinic", "acid", "(", "SA", ")", "(", "Xu", "et", "al.", ",", "2017a", ")", ",", "5-FU", "and", "CA", "(", "Fang", "et", "al.", ",", "2021", ")", ",", "MTX", "and", "ursolic", "acid", "(", "UA", ")", "(", "Figure", "8)", "(", "Lan", "et", "al.", ",", "2021a", ")", "." ] } ]
PMC10745221	With PRMT inhibitors entering clinical trials for cancer patients, it is important to understand how methionine deprivation on its own and in combination with these drugs may affect PRMT activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "PRMT", "inhibitors", "entering", "clinical", "trials", "for", "cancer", "patients", ",", "it", "is", "important", "to", "understand", "how", "methionine", "deprivation", "on", "its", "own", "and", "in", "combination", "with", "these", "drugs", "may", "affect", "PRMT", "activity", "." ] } ]
PMC9966931	Then, 400 µL of the spore suspension and 100 µL of the hybrid molecule solution were homogenized via gentle agitation, reaching final concentrations of 0.5%, 0.25%, and 0.125%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "400", "µL", "of", "the", "spore", "suspension", "and", "100", "µL", "of", "the", "hybrid", "molecule", "solution", "were", "homogenized", "via", "gentle", "agitation", ",", "reaching", "final", "concentrations", "of", "0.5", "%", ",", "0.25", "%", ",", "and", "0.125", "%", "." ] } ]
PMC5415764	Co-delivery of MDR-related anticancer drugs and P-gp modulators using nanocarrier strategy has demonstrated colocalization of more drugs in tumor tissue compared to free drug combinations181920.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-delivery", "of", "MDR-related", "anticancer", "drugs", "and", "P-gp", "modulators", "using", "nanocarrier", "strategy", "has", "demonstrated", "colocalization", "of", "more", "drugs", "in", "tumor", "tissue", "compared", "to", "free", "drug", "combinations181920", "." ] } ]
PMC11594806	Elevated cAMP levels activate cAMP-dependent protein kinase A (PKA), which then inhibits T-cell receptor (TCR)-dependent transmembrane signaling, thereby suppressing immune cell activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elevated", "cAMP", "levels", "activate", "cAMP-dependent", "protein", "kinase", "A", "(", "PKA", ")", ",", "which", "then", "inhibits", "T-cell", "receptor", "(TCR)-dependent", "transmembrane", "signaling", ",", "thereby", "suppressing", "immune", "cell", "activation", "." ] } ]
PMC9111184	They have attracted much interest due to their preventive effects in cardiovascular disease and their ability to act on cholesterol homeostasis when present in the diet (Falé et al., 2013, 2014; Ressaissi et al., 2021; Scalbert et al., 2005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "have", "attracted", "much", "interest", "due", "to", "their", "preventive", "effects", "in", "cardiovascular", "disease", "and", "their", "ability", "to", "act", "on", "cholesterol", "homeostasis", "when", "present", "in", "the", "diet", "(", "Falé", "et", "al.", ",", "2013", ",", "2014", ";", "Ressaissi", "et", "al.", ",", "2021", ";", "Scalbert", "et", "al.", ",", "2005", ")", "." ] } ]
PMC10380508	Some studies have found that PAX2 has both oncogenic and inhibitory effects on invasion during tumor development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "studies", "have", "found", "that", "PAX2", "has", "both", "oncogenic", "and", "inhibitory", "effects", "on", "invasion", "during", "tumor", "development", "." ] } ]
PMC9429973	Random forests were built to predict survival in the largest cohort (BeatAML).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Random", "forests", "were", "built", "to", "predict", "survival", "in", "the", "largest", "cohort", "(", "BeatAML", ")", "." ] } ]
PMC11604830	Instead, pegylated micelles and PFCE‐NE have been widely employed and investigated in preclinical and clinical studies. , , , , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Instead", ",", "pegylated", "micelles", "and", "PFCE‐NE", "have", "been", "widely", "employed", "and", "investigated", "in", "preclinical", "and", "clinical", "studies", ".", ",", ",", ",", ",", "," ] } ]
PMC9429973	In recent years, the rise of nanotechnology provides new horizons in AML treatment by using versatile and safe nano systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "the", "rise", "of", "nanotechnology", "provides", "new", "horizons", "in", "AML", "treatment", "by", "using", "versatile", "and", "safe", "nano", "systems", "." ] } ]
PMC10589262	IHC was performed using the Ventana Discovery XT autoimmunostainer (Ventana, Tucson, AZ, USA) with antibodies against KIT (1:200, Dako) and ATF6 (1:200, Abcam) according to the manufacturer’s standard protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IHC", "was", "performed", "using", "the", "Ventana", "Discovery", "XT", "autoimmunostainer", "(", "Ventana", ",", "Tucson", ",", "AZ", ",", "USA", ")", "with", "antibodies", "against", "KIT", "(", "1:200", ",", "Dako", ")", "and", "ATF6", "(", "1:200", ",", "Abcam", ")", "according", "to", "the", "manufacturer", "’s", "standard", "protocol", "." ] } ]
PMC11349530	As mentioned, adenosine, a tumor-produced IRF, is a promising target with at least 54 active clinical trials (107).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "mentioned", ",", "adenosine", ",", "a", "tumor-produced", "IRF", ",", "is", "a", "promising", "target", "with", "at", "least", "54", "active", "clinical", "trials", "(", "107", ")", "." ] } ]
PMC11577421	Microscale thermophoresis measurements of NP_BSA titrated with heparin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microscale", "thermophoresis", "measurements", "of", "NP_BSA", "titrated", "with", "heparin", "." ] } ]
PMC11015054	And subsequent KEGG pathway enrichment analysis showed a significant increase in centriolar extracellular capture network release (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "And", "subsequent", "KEGG", "pathway", "enrichment", "analysis", "showed", "a", "significant", "increase", "in", "centriolar", "extracellular", "capture", "network", "release", "(", "Figure", "6C", ")", "." ] } ]
PMC8701144	The WNT/β-catenin signaling pathway plays a pivotal role during development, organogenesis, stem cell maintenance and self-renewal of many tissues, and aberrant WNT/β-catenin signaling activity is associated with the development of several disease conditions including cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "WNT/β-catenin", "signaling", "pathway", "plays", "a", "pivotal", "role", "during", "development", ",", "organogenesis", ",", "stem", "cell", "maintenance", "and", "self-renewal", "of", "many", "tissues", ",", "and", "aberrant", "WNT/β-catenin", "signaling", "activity", "is", "associated", "with", "the", "development", "of", "several", "disease", "conditions", "including", "cancer", "." ] } ]
PMC11453018	H FACS analysis of Annexin V staining (histogram) in SKES1 cells following 72 hours of treatment with iP300w (1 μM), Dasatinib (1 μM), Dasatinib + iP300w, and Doxorubicin (1 μM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "FACS", "analysis", "of", "Annexin", "V", "staining", "(", "histogram", ")", "in", "SKES1", "cells", "following", "72", "hours", "of", "treatment", "with", "iP300w", "(", "1", "μM", ")", ",", "Dasatinib", "(", "1", "μM", ")", ",", "Dasatinib", "+", "iP300w", ",", "and", "Doxorubicin", "(", "1", "μM", ")", "." ] } ]
PMC9429973	MM cells are highly sensitive to drugs that target protein degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MM", "cells", "are", "highly", "sensitive", "to", "drugs", "that", "target", "protein", "degradation", "." ] } ]
PMC5600151	This triblock nanocarrier-siRNA complex showed an excellent siRNA protection ability and decreased BCL-2 gene expression by 50% compared to either PLL-siRNA complex or PAMAM-siRNA complex .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "triblock", "nanocarrier-siRNA", "complex", "showed", "an", "excellent", "siRNA", "protection", "ability", "and", "decreased", "BCL-2", "gene", "expression", "by", "50", "%", "compared", "to", "either", "PLL-siRNA", "complex", "or", "PAMAM-siRNA", "complex", "." ] } ]
PMC11013014	Unfortunately, all the other compounds have shown low anti-proliferative activity on both cancer cell lines at 1 μM. The obtained results display that compounds 1, 3, and 16(a–c) have a good selectivity towards HL60 over HCT116 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "all", "the", "other", "compounds", "have", "shown", "low", "anti-proliferative", "activity", "on", "both", "cancer", "cell", "lines", "at", "1", "μM.", "The", "obtained", "results", "display", "that", "compounds", "1", ",", "3", ",", "and", "16(a", "–", "c", ")", "have", "a", "good", "selectivity", "towards", "HL60", "over", "HCT116", "cell", "lines", "." ] } ]
PMC4485786	In sharp contrast, sarcomas of mice treated with either NHS-IL12 regimen showed a dense mononuclear infiltrate with NK cells, macrophages, and large numbers of CD4 and CD8 T cells (Fig. S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "sharp", "contrast", ",", "sarcomas", "of", "mice", "treated", "with", "either", "NHS-IL12", "regimen", "showed", "a", "dense", "mononuclear", "infiltrate", "with", "NK", "cells", ",", "macrophages", ",", "and", "large", "numbers", "of", "CD4", "and", "CD8", "T", "cells", "(", "Fig.", "S3", ")", "." ] } ]
PMC11694625	The antiproliferative activity of 3a–3d was evaluated by MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antiproliferative", "activity", "of", "3a–3d", "was", "evaluated", "by", "MTT", "assay", "." ] } ]
PMC11765988	Specifically, for Lofgren Syndrome (a manifestation of sarcoidosis), vimentin is believed to be the autoantigen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "for", "Lofgren", "Syndrome", "(", "a", "manifestation", "of", "sarcoidosis", ")", ",", "vimentin", "is", "believed", "to", "be", "the", "autoantigen", "." ] } ]
PMC8358006	The color and size of each point represented the −log10 (P value) values and enrichment scores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "color", "and", "size", "of", "each", "point", "represented", "the", "−log10", "(", "P", "value", ")", "values", "and", "enrichment", "scores", "." ] } ]
PMC10454535	We additionally evaluated the expression of proapoptotic proteins in treated RPMI 8226 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "We", "additionally", "evaluated", "the", "expression", "of", "proapoptotic", "proteins", "in", "treated", "RPMI", "8226", "cells", "." ] } ]
PMC11344246	Recent genomic data identified no readily druggable upregulated protein targets in MOC (18) apart from ERBB2 amplification in ∼26% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "genomic", "data", "identified", "no", "readily", "druggable", "upregulated", "protein", "targets", "in", "MOC", "(", "18", ")", "apart", "from", "ERBB2", "amplification", "in", "∼26", "%", "of", "cases", "." ] } ]
PMC11782780	Upregulation of miR-301b-3p considerably promoted HK2, PFKP, and PKM2 levels in cells, while further overexpression of EBF3 attenuated this promoting effect (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upregulation", "of", "miR-301b-3p", "considerably", "promoted", "HK2", ",", "PFKP", ",", "and", "PKM2", "levels", "in", "cells", ",", "while", "further", "overexpression", "of", "EBF3", "attenuated", "this", "promoting", "effect", "(", "Fig.", "5E", ")", "." ] } ]
PMC9503669	Release of Nef from the kinase may then result in the final receptor complexes captured in the crystal structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Release", "of", "Nef", "from", "the", "kinase", "may", "then", "result", "in", "the", "final", "receptor", "complexes", "captured", "in", "the", "crystal", "structures", "." ] } ]
PMC9429973	All pts provided informed consent prior to study entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "pts", "provided", "informed", "consent", "prior", "to", "study", "entry", "." ] } ]
PMC9878562	MFI (by flow cytometry) reports the mean ± SD (Dunnett’s multiple comparisons, ONE-WAY ANOVA p ≤ 0.01, **p ≤ 0.0001) of four independent experiments performed in triplicates. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MFI", "(", "by", "flow", "cytometry", ")", "reports", "the", "mean", "±", "SD", "(", "Dunnett", "’s", "multiple", "comparisons", ",", "ONE-WAY", "ANOVA", "", "", "p", "≤", "0.01", ",", "", "", "", "", "p", "≤", "0.0001", ")", "of", "four", "independent", "experiments", "performed", "in", "triplicates", ".", "(" ] } ]
PMC11720107	In the CACO-2 cell line, the Harnaś garlic extract decreased SOD1 protein expression by 56.06 pg/mL compared with the control (Figure 8E).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "CACO-2", "cell", "line", ",", "the", "Harnaś", "garlic", "extract", "decreased", "SOD1", "protein", "expression", "by", "56.06", "pg/mL", "compared", "with", "the", "control", "(", "Figure", "8E", ")", "." ] } ]
PMC10142392	PCL, in particular, is popular in this field due to its biologically inert nature and the slow hydrolytic cleavage of its ester groups under physiological conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCL", ",", "in", "particular", ",", "is", "popular", "in", "this", "field", "due", "to", "its", "biologically", "inert", "nature", "and", "the", "slow", "hydrolytic", "cleavage", "of", "its", "ester", "groups", "under", "physiological", "conditions", "." ] } ]
PMC11365427	Dual-luciferase reporter gene experiment of ATF3 transcriptionally activating DR5 in KEK-293T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Dual-luciferase", "reporter", "gene", "experiment", "of", "ATF3", "transcriptionally", "activating", "DR5", "in", "KEK-293", "T", "cells", "." ] } ]
PMC8316344	While FTH1, FTL, FPN1, and PCBP2 are critical to reduce intracellular iron, TF, TFRC, and SCL11A2 are critical to absorb and transport iron into the cytoplasm [12, 13, 20–23].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "FTH1", ",", "FTL", ",", "FPN1", ",", "and", "PCBP2", "are", "critical", "to", "reduce", "intracellular", "iron", ",", "TF", ",", "TFRC", ",", "and", "SCL11A2", "are", "critical", "to", "absorb", "and", "transport", "iron", "into", "the", "cytoplasm", "[", "12", ",", "13", ",", "20–23", "]", "." ] } ]
PMC7519871	The IC50 values of WDL, BA and EGCG were 14.85±0.70 µM, 12.82±0.37 µM and 29.22 ±1.91µM respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "values", "of", "WDL", ",", "BA", "and", "EGCG", "were", "14.85±0.70", "µM", ",", "12.82±0.37", "µM", "and", "29.22", "±1.91µM", "respectively", "." ] } ]
PMC6835428	Moreover, OC spheroids can be xenografted, thus allowing drug-sensitivity tests in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "OC", "spheroids", "can", "be", "xenografted", ",", "thus", "allowing", "drug-sensitivity", "tests", "in", "vivo", "." ] } ]
PMC11463018	Further reductive amination of 2-NH2 on triazolopyridine core with methyl 4-formylbenzoate gave intermediates 15a-m, which upon treatment with an aqueous NH2OH/NaOH solution provided hydroxamate analogues 16a-m.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "reductive", "amination", "of", "2-NH2", "on", "triazolopyridine", "core", "with", "methyl", "4-formylbenzoate", "gave", "intermediates", "15a-m", ",", "which", "upon", "treatment", "with", "an", "aqueous", "NH2OH/NaOH", "solution", "provided", "hydroxamate", "analogues", "16a-m", "." ] } ]
PMC8567602	In keeping, synovial sarcoma cell lines vary in levels of retained CBAF (Fig. 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "keeping", ",", "synovial", "sarcoma", "cell", "lines", "vary", "in", "levels", "of", "retained", "CBAF", "(", "Fig.", "6C", ")", "." ] } ]
PMC9429973	DNA analysis concerned sequencing of relevant coding exons, including flanking splice-site consensus sequences, of the eight major genes involved in secondary congenital erythrocytosis (EPOR, HBB, HBA1, HBA2, VHL, EPAS1, ELGN1, and BPGM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "analysis", "concerned", "sequencing", "of", "relevant", "coding", "exons", ",", "including", "flanking", "splice-site", "consensus", "sequences", ",", "of", "the", "eight", "major", "genes", "involved", "in", "secondary", "congenital", "erythrocytosis", "(", "EPOR", ",", "HBB", ",", "HBA1", ",", "HBA2", ",", "VHL", ",", "EPAS1", ",", "ELGN1", ",", "and", "BPGM", ")", "." ] } ]
PMC11672617	Consequently, the energy derived from the metabolic oxidation reaction is dissipated as heat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "the", "energy", "derived", "from", "the", "metabolic", "oxidation", "reaction", "is", "dissipated", "as", "heat", "." ] } ]
PMC11676670	At the time of sample collection, the patient’s disease was classified as stage IV, meaning the cancer was highly advanced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "time", "of", "sample", "collection", ",", "the", "patient", "’s", "disease", "was", "classified", "as", "stage", "IV", ",", "meaning", "the", "cancer", "was", "highly", "advanced", "." ] } ]
PMC11279397	Consequently, Perilla frutescens holds significant application prospects in the field of antiviral therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "Perilla", "frutescens", "holds", "significant", "application", "prospects", "in", "the", "field", "of", "antiviral", "therapy", "." ] } ]
PMC10890055	The milling balls were composed of ZrO2, while the ball-to-powder weight ratio was equal to 5:1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "milling", "balls", "were", "composed", "of", "ZrO2", ",", "while", "the", "ball-to-powder", "weight", "ratio", "was", "equal", "to", "5:1", "." ] } ]
PMC10840195	A pipettor and pipette tip with the tip cut off were used to absorb the beads and ensure that the amount of beads in each tube is the same.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "pipettor", "and", "pipette", "tip", "with", "the", "tip", "cut", "off", "were", "used", "to", "absorb", "the", "beads", "and", "ensure", "that", "the", "amount", "of", "beads", "in", "each", "tube", "is", "the", "same", "." ] } ]
PMC10840195	EMT involves a variety of signaling pathways, including transforming growth factor β (TGF-β), Wnt/β-catenin, etc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EMT", "involves", "a", "variety", "of", "signaling", "pathways", ",", "including", "transforming", "growth", "factor", "β", "(", "TGF-β", ")", ",", "Wnt/β-catenin", ",", "etc", "." ] } ]
PMC11477621	Subsequent copper(II)-catalyzed click reaction afforded triazole intermediate 18, which underwent amidation with various o-phenylenediamines to furnish target compounds 19a–f. The advanced intermediate 9 was coupled with o-phenylenediamine to result in an additional target compound 20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequent", "copper(II)-catalyzed", "click", "reaction", "afforded", "triazole", "intermediate", "18", ",", "which", "underwent", "amidation", "with", "various", "o-phenylenediamines", "to", "furnish", "target", "compounds", "19a", "–", "f.", "The", "advanced", "intermediate", "9", "was", "coupled", "with", "o-phenylenediamine", "to", "result", "in", "an", "additional", "target", "compound", "20", "." ] } ]
PMC11618052	Pro-apoptotic proteins promote cytochrome c release, while anti-apoptotic proteins regulate apoptosis by preventing cytochrome c release.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pro-apoptotic", "proteins", "promote", "cytochrome", "c", "release", ",", "while", "anti-apoptotic", "proteins", "regulate", "apoptosis", "by", "preventing", "cytochrome", "c", "release", "." ] } ]
PMC11585587	Concurrently, the phosphorylated protein expression levels of p-ERK1/2, p-MSK1, p-P90RSK, and p-MEK1/2 were diminished following RA treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Concurrently", ",", "the", "phosphorylated", "protein", "expression", "levels", "of", "p-ERK1/2", ",", "p-MSK1", ",", "p-P90RSK", ",", "and", "p-MEK1/2", "were", "diminished", "following", "RA", "treatment", "." ] } ]
PMC10831439	A goat F(ab’)2 anti-human IgG (H+L)-F(ab’)2-fragment (polyclonal, Jackson Immunoresearch, Ely, UK) and the CD19-CAR detection reagent (Miltenyi Biotech) were used to determine the percentage of CAR-expressing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "goat", "F(ab’)2", "anti-human", "IgG", "(H+L)-F(ab’)2-fragment", "(", "polyclonal", ",", "Jackson", "Immunoresearch", ",", "Ely", ",", "UK", ")", "and", "the", "CD19-CAR", "detection", "reagent", "(", "Miltenyi", "Biotech", ")", "were", "used", "to", "determine", "the", "percentage", "of", "CAR-expressing", "cells", "." ] } ]
PMC10605143	It is worth noting that although we did not observe changes in CDH1 expression in cells grown in 2D conditions, weaker CDH1 expression was observed in cell–cell contacts in spheroids formed by MDA-MB-468 cells overexpressing HSF1 (Figure 6e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "worth", "noting", "that", "although", "we", "did", "not", "observe", "changes", "in", "CDH1", "expression", "in", "cells", "grown", "in", "2D", "conditions", ",", "weaker", "CDH1", "expression", "was", "observed", "in", "cell", "–", "cell", "contacts", "in", "spheroids", "formed", "by", "MDA-MB-468", "cells", "overexpressing", "HSF1", "(", "Figure", "6e", ")", "." ] } ]
PMC11638255	b Individual tumor kinetics of Th-MYCN mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Individual", "tumor", "kinetics", "of", "Th-MYCN", "mice", "." ] } ]
PMC11684821	Statistical tests were performed in R and included multivariate permutation test for paired comparison (https://rdrr.io/cran/CNPS/), Shapiro-Wilk normality, paired 2-tailed t test, and Wilcoxon signed-rank test (not normally distributed).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "tests", "were", "performed", "in", "R", "and", "included", "multivariate", "permutation", "test", "for", "paired", "comparison", "(", "https://rdrr.io/cran/CNPS/", ")", ",", "Shapiro-Wilk", "normality", ",", "paired", "2-tailed", "t", "test", ",", "and", "Wilcoxon", "signed-rank", "test", "(", "not", "normally", "distributed", ")", "." ] } ]
PMC7185206	Inhibitor concentrations, listed in Supplemental Table 4, were based on common concentrations in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibitor", "concentrations", ",", "listed", "in", "Supplemental", "Table", "4", ",", "were", "based", "on", "common", "concentrations", "in", "the", "literature", "." ] } ]
PMC11394730	Initially, AMPK was activated by RV-induced SIRT1 activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initially", ",", "AMPK", "was", "activated", "by", "RV-induced", "SIRT1", "activation", "." ] } ]
PMC8753818	Responding market demands for biologicals, CHO cells must be cultured in huge densities in large bioreactors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Responding", "market", "demands", "for", "biologicals", ",", "CHO", "cells", "must", "be", "cultured", "in", "huge", "densities", "in", "large", "bioreactors", "." ] } ]
PMC11422150	Then, the cDNA was synthesized from the total RNA using ReverTra Ace qPCR RT Master Mix with gDNA Remover (TOYOBO) and THUNDERBIRD SYBR qPCR Mix (TOYOBO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "cDNA", "was", "synthesized", "from", "the", "total", "RNA", "using", "ReverTra", "Ace", "qPCR", "RT", "Master", "Mix", "with", "gDNA", "Remover", "(", "TOYOBO", ")", "and", "THUNDERBIRD", "SYBR", "qPCR", "Mix", "(", "TOYOBO", ")", "." ] } ]
PMC10958426	We further compared the cell-cell communication between DEGCNV and DEGreg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "compared", "the", "cell-cell", "communication", "between", "DEGCNV", "and", "DEGreg", "." ] } ]
PMC9046263	This data is summarized in Fig. 2C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "data", "is", "summarized", "in", "Fig.", "2C", "." ] } ]
PMC9429973	The AML patients were divided into two PIK3IP1 expression groups(n=29) and PIK3IP1 expression groups(n=24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "AML", "patients", "were", "divided", "into", "two", "PIK3IP1", "expression", "groups(n=29", ")", "and", "PIK3IP1", "expression", "groups(n=24", ")", "." ] } ]
PMC3035438	We also detected the simultaneous expression of the full-length chicken IgHM transcripts, presumed to be produced by alternative splicing leading to the removal of the human IgHG1 insert (Figure 1B and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "detected", "the", "simultaneous", "expression", "of", "the", "full-length", "chicken", "IgHM", "transcripts", ",", "presumed", "to", "be", "produced", "by", "alternative", "splicing", "leading", "to", "the", "removal", "of", "the", "human", "IgHG1", "insert", "(", "Figure", "1B", "and", "C", ")", "." ] } ]
PMC8097906	a Bright field images of VSM concentration series (1, 10, 25, 50 and 100 μg/ml VSM) treated RH-30 cells after 48 h compared to the solvent control (0.1% DMSO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Bright", "field", "images", "of", "VSM", "concentration", "series", "(", "1", ",", "10", ",", "25", ",", "50", "and", "100", "μg/ml", "VSM", ")", "treated", "RH-30", "cells", "after", "48", "h", "compared", "to", "the", "solvent", "control", "(", "0.1", "%", "DMSO", ")", "." ] } ]
PMC9429973	It has an addition of an acridine ring to the structure of ixazomib, which maintains high activity and selectivity, resulting in better metabolic stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "an", "addition", "of", "an", "acridine", "ring", "to", "the", "structure", "of", "ixazomib", ",", "which", "maintains", "high", "activity", "and", "selectivity", ",", "resulting", "in", "better", "metabolic", "stability", "." ] } ]
PMC5415764	Therefore, we concluded that the enhanced suppression efficacy of A2780/PTX cells was ascribed to the co-loading of PTX and TET in iRGD functionalized LPN with a sequential drug-release profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "concluded", "that", "the", "enhanced", "suppression", "efficacy", "of", "A2780/PTX", "cells", "was", "ascribed", "to", "the", "co-loading", "of", "PTX", "and", "TET", "in", "iRGD", "functionalized", "LPN", "with", "a", "sequential", "drug-release", "profile", "." ] } ]
PMC11587606	Fig. 1RHBDF1-overexpression in mammary epithelial cell leads to elevated-invasion rate and downregulated TJ/AJ markers. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1RHBDF1-overexpression", "in", "mammary", "epithelial", "cell", "leads", "to", "elevated-invasion", "rate", "and", "downregulated", "TJ/AJ", "markers", ".", "(" ] } ]
PMC10993311	This study was conducted according to the guidelines of the Declaration of Helsinki and all procedures involving human subjects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "was", "conducted", "according", "to", "the", "guidelines", "of", "the", "Declaration", "of", "Helsinki", "and", "all", "procedures", "involving", "human", "subjects", "." ] } ]
PMC11765988	While benign MLAD tends to involve smaller lymph nodes than other etiologies, ultrasound features alone are unreliable diagnostic tools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "benign", "MLAD", "tends", "to", "involve", "smaller", "lymph", "nodes", "than", "other", "etiologies", ",", "ultrasound", "features", "alone", "are", "unreliable", "diagnostic", "tools", "." ] } ]
PMC10196713	However, the molecular mechanism underlying the acquisition of cisplatin resistance by cancer cells remains largely unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "molecular", "mechanism", "underlying", "the", "acquisition", "of", "cisplatin", "resistance", "by", "cancer", "cells", "remains", "largely", "unknown", "." ] } ]
PMC9429973	Primary endpoints were safety and efficacy (≥2 consecutive platelet counts ≥50×10/L and increased ≥20×10/L from baseline without requiring rescue medication).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "endpoints", "were", "safety", "and", "efficacy", "(", "≥2", "consecutive", "platelet", "counts", "≥50", "×", "10/L", "and", "increased", "≥20", "×", "10/L", "from", "baseline", "without", "requiring", "rescue", "medication", ")", "." ] } ]
PMC11799620	Point out its antioxidant and cytoprotective potential against cadmium toxicity in rat liver homogenate cells and HepG2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "Point", "out", "its", "antioxidant", "and", "cytoprotective", "potential", "against", "cadmium", "toxicity", "in", "rat", "liver", "homogenate", "cells", "and", "HepG2", "." ] } ]

PMC9429973

There were 17/24 (70.8%) patients who completed 3 cycles: 3 showed CR; 2 showed VGPR; 11 showed PR and 7 with progressive disease as shown in the Figure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "17/24", "(", "70.8", "%", ")", "patients", "who", "completed", "3", "cycles", ":", "3", "showed", "CR", ";", "2", "showed", "VGPR", ";", "11", "showed", "PR", "and", "7", "with", "progressive", "disease", "as", "shown", "in", "the", "Figure", "." ] } ]

PMC11790971

Mann–Whitney U tests were employed to compare the feature values of different cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mann", "–", "Whitney", "U", "tests", "were", "employed", "to", "compare", "the", "feature", "values", "of", "different", "cell", "lines", "." ] } ]

PMC11499955

Surprisingly, the amount of TMPP-H15 was also significantly high.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surprisingly", ",", "the", "amount", "of", "TMPP-H15", "was", "also", "significantly", "high", "." ] } ]

PMC9599726

Therefore, the development of novel therapeutic strategies remains essential to improve patient outcome.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "development", "of", "novel", "therapeutic", "strategies", "remains", "essential", "to", "improve", "patient", "outcome", "." ] } ]

PMC7153288

Five gene clusters in Streptomyces sp. SS1-1 showing moderate to high similarities with known gene clusters in Streptomyces species were terpene (with hopene of Streptomyces coelicolor A3(2) with 92% similarity), siderophore (with desferrioxamine B of Streptomyces coelicolor A3(2) with 83% similarity), type 2 polyketide (with spore pigment of Streptomyces avermitilis with 75% similarity), melanin (with melanin of Streptomyces avermitilis with 57% similarity), and type 1 PKS (with hitachimycin of Streptomyces scarisporus with 54% similarity).

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PMC11794588

The ability of lupeol to protect C. elegans from oxidative damage further supports its antioxidant and health-promoting effects.

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PMC7039683

B–D) Surface plots for wild-type embryos at 11 hpf injected at the 1 cell stage with GFP reporter constructs for cldne +3, cldne −11, and cldne −8 elements.

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PMC11682525

The hHFSCs and SH-SY5Y cells were initially seeded in 96-well plates.

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PMC11078693

Collect media with floating cells into a 50 mL conical tube.b.

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PMC9429973

Aims: To estimate prognostic properties of palpable splenomegaly and potential differences between PMF and SMF patients.

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PMC11474209

WHO Alert Level 1 for cyanobacterial blooms in recreational waters occurs when the chlorophyll-a level exceeds 12 micrograms per litre and cyanobacteria dominate.

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PMC11766350

However, both shRNA samples showed significantly reduced yields per cell compared to the non-TRAIL control 2.07 × 10 vg/cell, p < 0.001, t-test) (Figure S1).

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PMC11754291

These results visually reinforce the differential effects of CM, CMK, and CMiK on melanocyte morphology, pigmentation, and proliferation, highlighting the contribution of irradiated keratinocytes to melanogenesis and cell growth.

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PMC11257988

Rat sarcoma (RAS) genes are the most commonly mutated oncogenes in human cancers, with Kirsten rat sarcoma (KRAS) being the most common subtype.

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PMC10547921

Stephan Rigol has synthesized the thailanstatin analogs 85 and 86, which have the IC50 value of picomoles.

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PMC8009078

No abnormal variation of the RoG value was found in any of the systems.

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PMC11300085

The intention of study was to investigate the effect of chemerin on biological behaviors of OC cells and reveal the underlying specific mechanism.

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PMC10391797

ANOVA, analysis of variance; AML, acute myeloid leukemia; BMMC, bone marrow mononuclear cells; CAR, chimeric antigen receptor; NKG2D, natural-killer group 2 member; PBMCs, peripheral blood mononuclear cells.

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PMC9429973

Results: The detection algorithm achieved high overall accuracy for detecting nucleated cells in microscopy images (sensitivity and precision of 91.6% and 91.3% respectively).

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PMC11499381

Normalized curves were generated for presentation by combining the mean of data points from normalized individual experiments.

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PMC8632470

This Japanese celery could be further explored for its potential as a plant-based nephroprotective drug.

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PMC11665555

Both regulators are known as transcriptional repressors of EMT in favor of epithelial differentiation (20, 44).

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PMC9429973

Prognosis of der(1;7) MDS cases tended to be better than -7/del(7q) cases (HR=0.71, p=0.098), but poorer than +1q (HR=1.36, p=0.11) and others cases (HR=1.8, p<0.001).

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PMC9019892

Approximately 15 000 new GIST patients are diagnosed annually worldwide .

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PMC9429973

cPCDMT1 is critical for the proliferation of CML-BC through the regulation of DNA replication and may represent a novel target for therapy.

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PMC10218459

Another typical feature of ES is the onset in childhood and adolescence, with a peak between the age of 5 and 24 years .

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PMC4360730

In addition to the official term name, each term is associated with a range of synonyms that represent alternate phrasings or related concepts.

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PMC11727062

Monomers derived from cold herbal sources exhibit a range of pharmacological effects, including antioxidant, anti-inflammatory, and antimicrobial properties.

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PMC10033453

The following day, cells were treated with either MOI 10 or 1 VMG, poly (I:C) (2 μg/mL) (Innaxon, Tewkesbury, UK) plus Lipofectamine 3000 (2 μL/mL) (Thermo Fisher Scientific), or media-only control.

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PMC10507284

Further differential analysis based on STS tissue data in TCGA and normal tissue data in GTEx also indicates that TROAP is abnormally increased in STS.

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PMC10482220

Arrows indicate transfected cells expressing GFP fusions.

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PMC11790599

Actin cytoskeleton, Rac1, and cholesterol are required for macropinosome formation.

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PMC9275501

Some natural active ingredients and chemotherapy drugs can be coupled together via ester bonds or acetal bonds to form carrier-free nano-systems to obtain high drug loading and synergistic antitumor effects, such as PTX and succinic acid (SA) (Xu et al., 2017a), 5-FU and CA (Fang et al., 2021), MTX and ursolic acid (UA) (Figure 8) (Lan et al., 2021a).

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PMC10745221

With PRMT inhibitors entering clinical trials for cancer patients, it is important to understand how methionine deprivation on its own and in combination with these drugs may affect PRMT activity.

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PMC9966931

Then, 400 µL of the spore suspension and 100 µL of the hybrid molecule solution were homogenized via gentle agitation, reaching final concentrations of 0.5%, 0.25%, and 0.125%.

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PMC5415764

Co-delivery of MDR-related anticancer drugs and P-gp modulators using nanocarrier strategy has demonstrated colocalization of more drugs in tumor tissue compared to free drug combinations181920.

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PMC11594806

Elevated cAMP levels activate cAMP-dependent protein kinase A (PKA), which then inhibits T-cell receptor (TCR)-dependent transmembrane signaling, thereby suppressing immune cell activation.

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PMC9111184

They have attracted much interest due to their preventive effects in cardiovascular disease and their ability to act on cholesterol homeostasis when present in the diet (Falé et al., 2013, 2014; Ressaissi et al., 2021; Scalbert et al., 2005).

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PMC10380508

Some studies have found that PAX2 has both oncogenic and inhibitory effects on invasion during tumor development.

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PMC9429973

Random forests were built to predict survival in the largest cohort (BeatAML).

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PMC11604830

Instead, pegylated micelles and PFCE‐NE have been widely employed and investigated in preclinical and clinical studies. , , , , ,

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PMC9429973

In recent years, the rise of nanotechnology provides new horizons in AML treatment by using versatile and safe nano systems.

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PMC10589262

IHC was performed using the Ventana Discovery XT autoimmunostainer (Ventana, Tucson, AZ, USA) with antibodies against KIT (1:200, Dako) and ATF6 (1:200, Abcam) according to the manufacturer’s standard protocol.

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PMC11349530

As mentioned, adenosine, a tumor-produced IRF, is a promising target with at least 54 active clinical trials (107).

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PMC11577421

Microscale thermophoresis measurements of NP_BSA titrated with heparin.

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PMC11015054

And subsequent KEGG pathway enrichment analysis showed a significant increase in centriolar extracellular capture network release (Figure 6C).

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PMC8701144

The WNT/β-catenin signaling pathway plays a pivotal role during development, organogenesis, stem cell maintenance and self-renewal of many tissues, and aberrant WNT/β-catenin signaling activity is associated with the development of several disease conditions including cancer .

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PMC11453018

H FACS analysis of Annexin V staining (histogram) in SKES1 cells following 72 hours of treatment with iP300w (1 μM), Dasatinib (1 μM), Dasatinib + iP300w, and Doxorubicin (1 μM).

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PMC9429973

MM cells are highly sensitive to drugs that target protein degradation.

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PMC5600151

This triblock nanocarrier-siRNA complex showed an excellent siRNA protection ability and decreased BCL-2 gene expression by 50% compared to either PLL-siRNA complex or PAMAM-siRNA complex .

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PMC11013014

Unfortunately, all the other compounds have shown low anti-proliferative activity on both cancer cell lines at 1 μM. The obtained results display that compounds 1, 3, and 16(a–c) have a good selectivity towards HL60 over HCT116 cell lines.

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PMC4485786

In sharp contrast, sarcomas of mice treated with either NHS-IL12 regimen showed a dense mononuclear infiltrate with NK cells, macrophages, and large numbers of CD4 and CD8 T cells (Fig. S3).

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PMC11694625

The antiproliferative activity of 3a–3d was evaluated by MTT assay.

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PMC11765988

Specifically, for Lofgren Syndrome (a manifestation of sarcoidosis), vimentin is believed to be the autoantigen.

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PMC8358006

The color and size of each point represented the −log10 (P value) values and enrichment scores.

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PMC10454535

We additionally evaluated the expression of proapoptotic proteins in treated RPMI 8226 cells.

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PMC11344246

Recent genomic data identified no readily druggable upregulated protein targets in MOC (18) apart from ERBB2 amplification in ∼26% of cases.

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PMC11782780

Upregulation of miR-301b-3p considerably promoted HK2, PFKP, and PKM2 levels in cells, while further overexpression of EBF3 attenuated this promoting effect (Fig. 5E).

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PMC9503669

Release of Nef from the kinase may then result in the final receptor complexes captured in the crystal structures.

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PMC9429973

All pts provided informed consent prior to study entry.

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PMC9878562

MFI (by flow cytometry) reports the mean ± SD (Dunnett’s multiple comparisons, ONE-WAY ANOVA **p ≤ 0.01, ****p ≤ 0.0001) of four independent experiments performed in triplicates. (

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PMC11720107

In the CACO-2 cell line, the Harnaś garlic extract decreased SOD1 protein expression by 56.06 pg/mL compared with the control (Figure 8E).

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PMC10142392

PCL, in particular, is popular in this field due to its biologically inert nature and the slow hydrolytic cleavage of its ester groups under physiological conditions.

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PMC11365427

Dual-luciferase reporter gene experiment of ATF3 transcriptionally activating DR5 in KEK-293T cells.

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PMC8316344

While FTH1, FTL, FPN1, and PCBP2 are critical to reduce intracellular iron, TF, TFRC, and SCL11A2 are critical to absorb and transport iron into the cytoplasm [12, 13, 20–23].

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PMC7519871

The IC50 values of WDL, BA and EGCG were 14.85±0.70 µM, 12.82±0.37 µM and 29.22 ±1.91µM respectively.

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PMC6835428

Moreover, OC spheroids can be xenografted, thus allowing drug-sensitivity tests in vivo.

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PMC11463018

Further reductive amination of 2-NH2 on triazolopyridine core with methyl 4-formylbenzoate gave intermediates 15a-m, which upon treatment with an aqueous NH2OH/NaOH solution provided hydroxamate analogues 16a-m.

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PMC8567602

In keeping, synovial sarcoma cell lines vary in levels of retained CBAF (Fig. 6C).

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PMC9429973

DNA analysis concerned sequencing of relevant coding exons, including flanking splice-site consensus sequences, of the eight major genes involved in secondary congenital erythrocytosis (EPOR, HBB, HBA1, HBA2, VHL, EPAS1, ELGN1, and BPGM).

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PMC11672617

Consequently, the energy derived from the metabolic oxidation reaction is dissipated as heat.

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PMC11676670

At the time of sample collection, the patient’s disease was classified as stage IV, meaning the cancer was highly advanced.

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PMC11279397

Consequently, Perilla frutescens holds significant application prospects in the field of antiviral therapy.

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PMC10890055

The milling balls were composed of ZrO2, while the ball-to-powder weight ratio was equal to 5:1.

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PMC10840195

A pipettor and pipette tip with the tip cut off were used to absorb the beads and ensure that the amount of beads in each tube is the same.

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PMC10840195

EMT involves a variety of signaling pathways, including transforming growth factor β (TGF-β), Wnt/β-catenin, etc.

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PMC11477621

Subsequent copper(II)-catalyzed click reaction afforded triazole intermediate 18, which underwent amidation with various o-phenylenediamines to furnish target compounds 19a–f. The advanced intermediate 9 was coupled with o-phenylenediamine to result in an additional target compound 20.

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PMC11618052

Pro-apoptotic proteins promote cytochrome c release, while anti-apoptotic proteins regulate apoptosis by preventing cytochrome c release.

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PMC11585587

Concurrently, the phosphorylated protein expression levels of p-ERK1/2, p-MSK1, p-P90RSK, and p-MEK1/2 were diminished following RA treatment.

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PMC10831439

A goat F(ab’)2 anti-human IgG (H+L)-F(ab’)2-fragment (polyclonal, Jackson Immunoresearch, Ely, UK) and the CD19-CAR detection reagent (Miltenyi Biotech) were used to determine the percentage of CAR-expressing cells.

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PMC10605143

It is worth noting that although we did not observe changes in CDH1 expression in cells grown in 2D conditions, weaker CDH1 expression was observed in cell–cell contacts in spheroids formed by MDA-MB-468 cells overexpressing HSF1 (Figure 6e).

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PMC11638255

b Individual tumor kinetics of Th-MYCN mice.

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PMC11684821

Statistical tests were performed in R and included multivariate permutation test for paired comparison (https://rdrr.io/cran/CNPS/), Shapiro-Wilk normality, paired 2-tailed t test, and Wilcoxon signed-rank test (not normally distributed).

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PMC7185206

Inhibitor concentrations, listed in Supplemental Table 4, were based on common concentrations in the literature.

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PMC11394730

Initially, AMPK was activated by RV-induced SIRT1 activation .

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PMC8753818

Responding market demands for biologicals, CHO cells must be cultured in huge densities in large bioreactors.

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PMC11422150

Then, the cDNA was synthesized from the total RNA using ReverTra Ace qPCR RT Master Mix with gDNA Remover (TOYOBO) and THUNDERBIRD SYBR qPCR Mix (TOYOBO).

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PMC10958426

We further compared the cell-cell communication between DEGCNV and DEGreg.

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PMC9046263

This data is summarized in Fig. 2C.

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PMC9429973

The AML patients were divided into two PIK3IP1 expression groups(n=29) and PIK3IP1 expression groups(n=24).

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PMC3035438

We also detected the simultaneous expression of the full-length chicken IgHM transcripts, presumed to be produced by alternative splicing leading to the removal of the human IgHG1 insert (Figure 1B and C).

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PMC8097906

a Bright field images of VSM concentration series (1, 10, 25, 50 and 100 μg/ml VSM) treated RH-30 cells after 48 h compared to the solvent control (0.1% DMSO).

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PMC9429973

It has an addition of an acridine ring to the structure of ixazomib, which maintains high activity and selectivity, resulting in better metabolic stability.

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PMC5415764

Therefore, we concluded that the enhanced suppression efficacy of A2780/PTX cells was ascribed to the co-loading of PTX and TET in iRGD functionalized LPN with a sequential drug-release profile.

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PMC11587606

Fig. 1RHBDF1-overexpression in mammary epithelial cell leads to elevated-invasion rate and downregulated TJ/AJ markers. (

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PMC10993311

This study was conducted according to the guidelines of the Declaration of Helsinki and all procedures involving human subjects.

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PMC11765988

While benign MLAD tends to involve smaller lymph nodes than other etiologies, ultrasound features alone are unreliable diagnostic tools.

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PMC10196713

However, the molecular mechanism underlying the acquisition of cisplatin resistance by cancer cells remains largely unknown.

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PMC9429973

Primary endpoints were safety and efficacy (≥2 consecutive platelet counts ≥50×10/L and increased ≥20×10/L from baseline without requiring rescue medication).

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PMC11799620

Point out its antioxidant and cytoprotective potential against cadmium toxicity in rat liver homogenate cells and HepG2.

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