OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11060216	The expression of the biomarkers was graded according to the standard as follows: <25% positive cells, 1; 26–50% positive cells, 2; 51–75% positive cells, 3; >76% positive cells, 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "the", "biomarkers", "was", "graded", "according", "to", "the", "standard", "as", "follows", ":", "<", "25", "%", "positive", "cells", ",", "1", ";", "26–50", "%", "positive", "cells", ",", "2", ";", "51–75", "%", "positive", "cells", ",", "3", ";", ">", "76", "%", "positive", "cells", ",", "4", "." ] } ]
PMC11155445	Several comprehensive reviews and compilation reports authored by Koch, Aly, and Saeed have systematically examined the literature pertaining to N-substituted-N-aroyl(acyl)thiourea chemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "comprehensive", "reviews", "and", "compilation", "reports", "authored", "by", "Koch", ",", "Aly", ",", "and", "Saeed", "have", "systematically", "examined", "the", "literature", "pertaining", "to", "N-substituted-N-aroyl(acyl)thiourea", "chemistry", "." ] } ]
PMC11306331	Negative values indicate condensate disruption.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Negative", "values", "indicate", "condensate", "disruption", "." ] } ]
PMC11548041	Single color controls included (1) DiO-stained MNVs, (2) unstained MNVs functionalized with 0.1 μM Cy5-aptamer-TEGChol, as well as a (3) dye only control consisting of 5 μM vibrant DiO in PBS that underwent ultracentrifugation and was resuspended in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single", "color", "controls", "included", "(", "1", ")", "DiO-stained", "MNVs", ",", "(", "2", ")", "unstained", "MNVs", "functionalized", "with", "0.1", "μM", "Cy5-aptamer-TEGChol", ",", "as", "well", "as", "a", "(", "3", ")", "dye", "only", "control", "consisting", "of", "5", "μM", "vibrant", "DiO", "in", "PBS", "that", "underwent", "ultracentrifugation", "and", "was", "resuspended", "in", "PBS", "." ] } ]
PMC10975211	Selenium compounds can potentially slow cancer cell development and trigger apoptosis in cancer cell culture models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selenium", "compounds", "can", "potentially", "slow", "cancer", "cell", "development", "and", "trigger", "apoptosis", "in", "cancer", "cell", "culture", "models", "." ] } ]
PMC11127909	Mitochondrial drug delivery systems are still immature and need further research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondrial", "drug", "delivery", "systems", "are", "still", "immature", "and", "need", "further", "research", "." ] } ]
PMC7022782	Furthermore, during this study, we evaluated if the dye-loading process could improve the aqueous stability of ICG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "during", "this", "study", ",", "we", "evaluated", "if", "the", "dye-loading", "process", "could", "improve", "the", "aqueous", "stability", "of", "ICG", "." ] } ]
PMC9960565	By adapting previous methodologies , two different procedures were implemented to conjugate cisplatin to the anionic PAMAM dendrimers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "adapting", "previous", "methodologies", ",", "two", "different", "procedures", "were", "implemented", "to", "conjugate", "cisplatin", "to", "the", "anionic", "PAMAM", "dendrimers", "." ] } ]
PMC11519583	d Expression of Wnt11 in isolated MPs treated with the indicated siRNAs was assessed using quantitative RT-PCR analysis (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Expression", "of", "Wnt11", "in", "isolated", "MPs", "treated", "with", "the", "indicated", "siRNAs", "was", "assessed", "using", "quantitative", "RT-PCR", "analysis", "(", "n", "=", "3", ")", "." ] } ]
PMC9429973	After two courses of R-ESHAP no response was achieved and Tisagenlecleucel was administrated on April 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "two", "courses", "of", "R-ESHAP", "no", "response", "was", "achieved", "and", "Tisagenlecleucel", "was", "administrated", "on", "April", "2021", "." ] } ]
PMC6133382	Digested peptides were desalted and purified by passing through a C18 sep-pak cartridge after inactivating trypsin by heating at 95 °C for 5 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Digested", "peptides", "were", "desalted", "and", "purified", "by", "passing", "through", "a", "C18", "sep-pak", "cartridge", "after", "inactivating", "trypsin", "by", "heating", "at", "95", "°", "C", "for", "5", "minutes", "." ] } ]
PMC10891340	We explored which stage of DPV life cycle was suppressed upon CCCP treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "explored", "which", "stage", "of", "DPV", "life", "cycle", "was", "suppressed", "upon", "CCCP", "treatment", "." ] } ]
PMC6190245	Apoptosis assessed by flow cytometry The apoptotic cells were detected by propidium iodide (PI) staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "assessed", "by", "flow", "cytometry", "The", "apoptotic", "cells", "were", "detected", "by", "propidium", "iodide", "(", "PI", ")", "staining", "." ] } ]
PMC11409031	≤0.001.	[ { "tags": [ "O", "O" ], "tokens": [ "≤0.001", "." ] } ]
PMC11679033	This overlap raises concerns about potential CBD-CIT interactions in patients treated with CBD therapeutics .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "overlap", "raises", "concerns", "about", "potential", "CBD-CIT", "interactions", "in", "patients", "treated", "with", "CBD", "therapeutics", "." ] } ]
PMC11387401	Beside proteins, host RNA molecules are reported to aid HIV-1 replication and latency maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beside", "proteins", ",", "host", "RNA", "molecules", "are", "reported", "to", "aid", "HIV-1", "replication", "and", "latency", "maintenance", "." ] } ]
PMC11740207	Given the morphological similarities among hypothetical developmental stages, we have divided the scatter dot plot’s region of interest into two distinct events: VSLSLCs and small LSLCs (SLSLCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "the", "morphological", "similarities", "among", "hypothetical", "developmental", "stages", ",", "we", "have", "divided", "the", "scatter", "dot", "plot", "’s", "region", "of", "interest", "into", "two", "distinct", "events", ":", "VSLSLCs", "and", "small", "LSLCs", "(", "SLSLCs", ")", "." ] } ]
PMC11779960	During malignant transformation, assuming the malignancy arose from a single mature T cell, the resulting lymphoma should homogenously and exclusively express only one TRBC chain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "malignant", "transformation", ",", "assuming", "the", "malignancy", "arose", "from", "a", "single", "mature", "T", "cell", ",", "the", "resulting", "lymphoma", "should", "homogenously", "and", "exclusively", "express", "only", "one", "TRBC", "chain", "." ] } ]
PMC6600253	Previous studies have indicated that G-quadruplexes obstruct telomerase activity and telomere extension .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "indicated", "that", "G-quadruplexes", "obstruct", "telomerase", "activity", "and", "telomere", "extension", "." ] } ]
PMC11572213	quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm downregulation of TET2 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "quantitative", "reverse", "transcription", "polymerase", "chain", "reaction", "(", "qRT-PCR", ")", "was", "performed", "to", "confirm", "downregulation", "of", "TET2", "expression", "." ] } ]
PMC10178190	CM incubation variably affected pERK1/2, depending upon the cell line tested and the source of the CM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CM", "incubation", "variably", "affected", "pERK1/2", ",", "depending", "upon", "the", "cell", "line", "tested", "and", "the", "source", "of", "the", "CM", "." ] } ]
PMC9681981	After 5 min incubation at room temperature, 1 μL of M-MuLV reverse transcriptase enzyme was added and mixed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "5", "min", "incubation", "at", "room", "temperature", ",", "1", "μL", "of", "M-MuLV", "reverse", "transcriptase", "enzyme", "was", "added", "and", "mixed", "." ] } ]
PMC11534377	To investigate the effect of 5-Aza on lung cancer we treated four lung cancer cell line models with increasing doses of 5-Aza.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "the", "effect", "of", "5-Aza", "on", "lung", "cancer", "we", "treated", "four", "lung", "cancer", "cell", "line", "models", "with", "increasing", "doses", "of", "5-Aza", "." ] } ]
PMC6461034	For faithful aliquoting of equal amounts of beads, it is essential to apply a stepwise strategy: invert the “stock” vial with beads 10 times and distribute a fraction (e.g., 1/4) of the “stock” to the “IP” tubes—restore the volume of the “stock” vial with IP buffer; perform a second distribution round by again distributing (only) a fraction of the “stock” and restoring the volume of the “stock” vial with IP buffer, etc.;	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "faithful", "aliquoting", "of", "equal", "amounts", "of", "beads", ",", "it", "is", "essential", "to", "apply", "a", "stepwise", "strategy", ":", "invert", "the", "“", "stock", "”", "vial", "with", "beads", "10", "times", "and", "distribute", "a", "fraction", "(", "e.g.", ",", "1/4", ")", "of", "the", "“", "stock", "”", "to", "the", "“", "IP", "”", "tubes", "—", "restore", "the", "volume", "of", "the", "“", "stock", "”", "vial", "with", "IP", "buffer", ";", "perform", "a", "second", "distribution", "round", "by", "again", "distributing", "(", "only", ")", "a", "fraction", "of", "the", "“", "stock", "”", "and", "restoring", "the", "volume", "of", "the", "“", "stock", "”", "vial", "with", "IP", "buffer", ",", "etc", ".", ";" ] } ]
PMC9111184	Hydroxycinnamic acid derivatives and EZ were added simultaneously with cholesterol to the apical compartment of the transwells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydroxycinnamic", "acid", "derivatives", "and", "EZ", "were", "added", "simultaneously", "with", "cholesterol", "to", "the", "apical", "compartment", "of", "the", "transwells", "." ] } ]
PMC9847912	In three independent assay runs, the IC50 value for the M3 mutant was 1.8 ± 0.90 nM (mean ±1 standard deviation).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "three", "independent", "assay", "runs", ",", "the", "IC50", "value", "for", "the", "M3", "mutant", "was", "1.8", "±", "0.90", "nM", "(", "mean", "±1", "standard", "deviation", ")", "." ] } ]
PMC9429973	Results: Patients were divided into the four prognostic groups proposed by the CLL-IPI as follows: 6 (17.2%) at low risk, 16 (45.7%) at intermediate risk, 10 (28.6%) at high risk, and 3 (8.6%) at very high risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Patients", "were", "divided", "into", "the", "four", "prognostic", "groups", "proposed", "by", "the", "CLL-IPI", "as", "follows", ":", "6", "(", "17.2", "%", ")", "at", "low", "risk", ",", "16", "(", "45.7", "%", ")", "at", "intermediate", "risk", ",", "10", "(", "28.6", "%", ")", "at", "high", "risk", ",", "and", "3", "(", "8.6", "%", ")", "at", "very", "high", "risk", "." ] } ]
PMC11087301	SOX2 functions as a stem cell TF that maintains CSC properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SOX2", "functions", "as", "a", "stem", "cell", "TF", "that", "maintains", "CSC", "properties", "." ] } ]
PMC9739791	Due to non-specific binding to biomolecules, all three FDA-approved platinum drugs exhibit acute toxicity to various organs, including nephrotoxicity , ototoxicity , and neurotoxicity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "non-specific", "binding", "to", "biomolecules", ",", "all", "three", "FDA-approved", "platinum", "drugs", "exhibit", "acute", "toxicity", "to", "various", "organs", ",", "including", "nephrotoxicity", ",", "ototoxicity", ",", "and", "neurotoxicity", "." ] } ]
PMC6642070	Insert is the average normalized to control in baseline. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Insert", "is", "the", "average", "normalized", "to", "control", "in", "baseline", ".", "(" ] } ]
PMC6889484	Replication kinetics from duplicate flasks are indicated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Replication", "kinetics", "from", "duplicate", "flasks", "are", "indicated", ".", "(" ] } ]
PMC9429973	Primary EMD is found in newly diagnosed MM (NDMM) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "EMD", "is", "found", "in", "newly", "diagnosed", "MM", "(", "NDMM", ")", "patients", "." ] } ]
PMC11742047	A total of 1432 and 501 possible compounds was found using LC–MS in both ionization modes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "1432", "and", "501", "possible", "compounds", "was", "found", "using", "LC", "–", "MS", "in", "both", "ionization", "modes", "." ] } ]
PMC11413393	Mini-Turbo plasmid (pSTV6-N-miniTurbo-BirA) was obtained as a gift from Dr. Brian Raught’s lab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mini-Turbo", "plasmid", "(", "pSTV6-N-miniTurbo-BirA", ")", "was", "obtained", "as", "a", "gift", "from", "Dr.", "Brian", "Raught", "’s", "lab", "." ] } ]
PMC11549062	Vulnerable plaques, featured by a large necrotic core with a high content of lipids and inflammatory cells, are covered by a thin fibrous cap, whereas stable plaques are represented with thick fibrous caps with vascular smooth muscle cells (VSMCs) producing extracellular matrix .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vulnerable", "plaques", ",", "featured", "by", "a", "large", "necrotic", "core", "with", "a", "high", "content", "of", "lipids", "and", "inflammatory", "cells", ",", "are", "covered", "by", "a", "thin", "fibrous", "cap", ",", "whereas", "stable", "plaques", "are", "represented", "with", "thick", "fibrous", "caps", "with", "vascular", "smooth", "muscle", "cells", "(", "VSMCs", ")", "producing", "extracellular", "matrix", "." ] } ]
PMC11055443	Chenari et al. also indicated that MSCs modulate the inflammatory responses to BCG infection and decrease the secretion of TNF-α and IL-1β in the alveolar fluid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chenari", "et", "al.", "also", "indicated", "that", "MSCs", "modulate", "the", "inflammatory", "responses", "to", "BCG", "infection", "and", "decrease", "the", "secretion", "of", "TNF-α", "and", "IL-1β", "in", "the", "alveolar", "fluid", "." ] } ]
PMC11594641	Moreover, exploring the targeting of Rab27 in combination with other proteins involved in sEV secretion, such as TSG101, could additionally improve the therapeutic outcome and become a novel strategy for preventing melanoma progression and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "exploring", "the", "targeting", "of", "Rab27", "in", "combination", "with", "other", "proteins", "involved", "in", "sEV", "secretion", ",", "such", "as", "TSG101", ",", "could", "additionally", "improve", "the", "therapeutic", "outcome", "and", "become", "a", "novel", "strategy", "for", "preventing", "melanoma", "progression", "and", "metastasis", "." ] } ]
PMC11634794	Following a 14-day incubation period, the cells were fixed with 75% methanol and stained with 0.1% crystal violet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "a", "14-day", "incubation", "period", ",", "the", "cells", "were", "fixed", "with", "75", "%", "methanol", "and", "stained", "with", "0.1", "%", "crystal", "violet", "." ] } ]
PMC11786704	Current research shows that the MAPK signaling pathway plays a complex and diverse role in inflammation and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Current", "research", "shows", "that", "the", "MAPK", "signaling", "pathway", "plays", "a", "complex", "and", "diverse", "role", "in", "inflammation", "and", "apoptosis", "." ] } ]
PMC11680391	However, our analysis demonstrated a wide variation in opinion about the communication between farmers and their veterinarians during udder health consulting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "our", "analysis", "demonstrated", "a", "wide", "variation", "in", "opinion", "about", "the", "communication", "between", "farmers", "and", "their", "veterinarians", "during", "udder", "health", "consulting", "." ] } ]
PMC6461034	The PhosphoSitePlus‐ and NetworKIN‐based approaches depend on the availability of comprehensive curated data on experimentally observed kinase–substrate relationships or reliable predictions thereof, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PhosphoSitePlus‐", "and", "NetworKIN‐based", "approaches", "depend", "on", "the", "availability", "of", "comprehensive", "curated", "data", "on", "experimentally", "observed", "kinase", "–", "substrate", "relationships", "or", "reliable", "predictions", "thereof", ",", "respectively", "." ] } ]
PMC9429973	S. Molica, C. Patti, P. Sportoletti, A. Chiarenza, A. M. Giordano, F. Chiurazzi, N. Di Renzo, P. Musto, F. Pane, F. Di Raimondo, L. Trentin, F. R. Mauro, D. Giannarelli Department Hematology, Hull University Teaching Hospitals NHS Trust, Hull, UK, Hall, United Kingdom; hematology, Ospedale Cervello, Palermo; Hematology Unit, University Perugia, Perugia; Hematology Unit, Ferrarotto Hospital, Catania; 5Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari; Department of Clinical Medicine and Surgery, Hematology Unit, Federco II Medical School Napoli, Napoli; Hematology Unit, Presidio Ospedaliero Vito Fazi, Lecce; Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari; Department of Clinical Medicine and Surgery, Hematology Unit, Federico II Medical School Napoli, Napoli; Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua; Hematology, Department of Translational and Precision Medicine, Sapienza University Rome; Biostatistic Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Rome, Italy Background: Changes in the treatment landscape of CLL have complicated the decision-making processes, especially in the context of relapsed/refractory (R/R) disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S.", "Molica", ",", "C.", "Patti", ",", "P.", "Sportoletti", ",", "A.", "Chiarenza", ",", "A.", "M.", "Giordano", ",", "F.", "Chiurazzi", ",", "N.", "Di", "Renzo", ",", "P.", "Musto", ",", "F.", "Pane", ",", "F.", "Di", "Raimondo", ",", "L.", "Trentin", ",", "F.", "R.", "Mauro", ",", "D.", "Giannarelli", "Department", "Hematology", ",", "Hull", "University", "Teaching", "Hospitals", "NHS", "Trust", ",", "Hull", ",", "UK", ",", "Hall", ",", "United", "Kingdom", ";", "hematology", ",", "Ospedale", "Cervello", ",", "Palermo", ";", "Hematology", "Unit", ",", "University", "Perugia", ",", "Perugia", ";", "Hematology", "Unit", ",", "Ferrarotto", "Hospital", ",", "Catania", ";", "5Department", "of", "Emergency", "and", "Organ", "Transplantation", "(", "D.E.T.O.", ")", ",", "Hematology", "Section", ",", "University", "of", "Bari", ",", "Bari", ";", "Department", "of", "Clinical", "Medicine", "and", "Surgery", ",", "Hematology", "Unit", ",", "Federco", "II", "Medical", "School", "Napoli", ",", "Napoli", ";", "Hematology", "Unit", ",", "Presidio", "Ospedaliero", "Vito", "Fazi", ",", "Lecce", ";", "Department", "of", "Emergency", "and", "Organ", "Transplantation", "(", "D.E.T.O.", ")", ",", "Hematology", "Section", ",", "University", "of", "Bari", ",", "Bari", ";", "Department", "of", "Clinical", "Medicine", "and", "Surgery", ",", "Hematology", "Unit", ",", "Federico", "II", "Medical", "School", "Napoli", ",", "Napoli", ";", "Hematology", "and", "Clinical", "Immunology", "Unit", ",", "Department", "of", "Medicine", ",", "University", "of", "Padua", ",", "Padua", ";", "Hematology", ",", "Department", "of", "Translational", "and", "Precision", "Medicine", ",", "Sapienza", "University", "Rome", ";", "Biostatistic", "Unit", ",", "Fondazione", "Policlinico", "Universitario", "A.", "Gemelli", "IRCCS", ",", "Rome", ",", "Rome", ",", "Italy", "Background", ":", "Changes", "in", "the", "treatment", "landscape", "of", "CLL", "have", "complicated", "the", "decision-making", "processes", ",", "especially", "in", "the", "context", "of", "relapsed/refractory", "(", "R/R", ")", "disease", "." ] } ]
PMC9429973	The decrease in the number of colony-forming cells of granulomonocytopoiesis was distinct in cell suspension samples stored for more than 10 months, but also did not reach significant values: 64%, 58% and 37%, respectively; p=0.451.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "decrease", "in", "the", "number", "of", "colony-forming", "cells", "of", "granulomonocytopoiesis", "was", "distinct", "in", "cell", "suspension", "samples", "stored", "for", "more", "than", "10", "months", ",", "but", "also", "did", "not", "reach", "significant", "values", ":", "64", "%", ",", "58", "%", "and", "37", "%", ",", "respectively", ";", "p=0.451", "." ] } ]
PMC11279598	To assess the effects of Manuka honey, we treated MCF-7 cells for 24 h with control or Manuka honey at 0.6%, 1.25%, 2.5%, or 5.0% (w/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "effects", "of", "Manuka", "honey", ",", "we", "treated", "MCF-7", "cells", "for", "24", "h", "with", "control", "or", "Manuka", "honey", "at", "0.6", "%", ",", "1.25", "%", ",", "2.5", "%", ",", "or", "5.0", "%", "(", "w/v", ")", "." ] } ]
PMC11680562	This combination could promote adherence to the vaginal mucosa and sustain the release of the drug and metal NPs at the cervical region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "combination", "could", "promote", "adherence", "to", "the", "vaginal", "mucosa", "and", "sustain", "the", "release", "of", "the", "drug", "and", "metal", "NPs", "at", "the", "cervical", "region", "." ] } ]
PMC10421378	To visualize the morphology of the dried powder microparticles, selected samples were analyzed using scanning electron microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "visualize", "the", "morphology", "of", "the", "dried", "powder", "microparticles", ",", "selected", "samples", "were", "analyzed", "using", "scanning", "electron", "microscopy", "." ] } ]
PMC11599565	These morphological changes correlate with the expression of a plethora of neuronal-defining markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "morphological", "changes", "correlate", "with", "the", "expression", "of", "a", "plethora", "of", "neuronal-defining", "markers", "." ] } ]
PMC11742290	Although the trial was terminated, there was evidence that BNC101 could infiltrate the CRC patient tumor and engage with overexpressed LGR5 receptors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "trial", "was", "terminated", ",", "there", "was", "evidence", "that", "BNC101", "could", "infiltrate", "the", "CRC", "patient", "tumor", "and", "engage", "with", "overexpressed", "LGR5", "receptors", "." ] } ]
PMC11532793	Plots showing the observed power and the observed false discovery rate (FDR) versus the number of replicate samples while controlling for different nominal FDR levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plots", "showing", "the", "observed", "power", "and", "the", "observed", "false", "discovery", "rate", "(", "FDR", ")", "versus", "the", "number", "of", "replicate", "samples", "while", "controlling", "for", "different", "nominal", "FDR", "levels", "." ] } ]
PMC10203589	Although the same therapies can effectively improve overall survival (OS) in these patients, understanding the molecular mechanisms of their pathogenesis and identifying new therapeutic targets are still urgently needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "same", "therapies", "can", "effectively", "improve", "overall", "survival", "(", "OS", ")", "in", "these", "patients", ",", "understanding", "the", "molecular", "mechanisms", "of", "their", "pathogenesis", "and", "identifying", "new", "therapeutic", "targets", "are", "still", "urgently", "needed", "." ] } ]
PMC9429973	There were no clinically significant changes in laboratory parameters or vital signs, no injection site reactions, serious adverse events, or deaths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", "clinically", "significant", "changes", "in", "laboratory", "parameters", "or", "vital", "signs", ",", "no", "injection", "site", "reactions", ",", "serious", "adverse", "events", ",", "or", "deaths", "." ] } ]
PMC11757230	As previously reported , cADSCs were confirmed for distinctive surface marker expression patterns (CD29, CD44, and CD90 positive; CD34, CD45, and HLA-DR negative) and tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "previously", "reported", ",", "cADSCs", "were", "confirmed", "for", "distinctive", "surface", "marker", "expression", "patterns", "(", "CD29", ",", "CD44", ",", "and", "CD90", "positive", ";", "CD34", ",", "CD45", ",", "and", "HLA-DR", "negative", ")", "and", "tri-lineage", "differentiation", "potential", "(", "adipogenesis", ",", "osteogenesis", ",", "and", "chondrogenesis", ")", "." ] } ]
PMC11499381	The resulting constructs were transfected into Cos7 and HEK293S cells, where we measured cAMP production in response to ligand stimulation, cell surface expression of receptor complexes, and BiFC fluorescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "constructs", "were", "transfected", "into", "Cos7", "and", "HEK293S", "cells", ",", "where", "we", "measured", "cAMP", "production", "in", "response", "to", "ligand", "stimulation", ",", "cell", "surface", "expression", "of", "receptor", "complexes", ",", "and", "BiFC", "fluorescence", "." ] } ]
PMC11727145	The 4 °C storage protocol was thus used for all experiments presented herein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "4", "°", "C", "storage", "protocol", "was", "thus", "used", "for", "all", "experiments", "presented", "herein", "." ] } ]
PMC11697189	Right semicircle green, prognostic protective factors; Right semicircular purple, prognostic risk factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", "semicircle", "green", ",", "prognostic", "protective", "factors", ";", "Right", "semicircular", "purple", ",", "prognostic", "risk", "factors", "." ] } ]
PMC11698348	While these studies have firmly established Elf5 as a crucial regulator of cell fate determination of epithelial tissues, there has been very limited information of the expression and function of Elf5 in skin and HFs [10–12] and no knowledge if Elf5 is involved in the activities of epidermal and HF stem cells (SCs) and their progenies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "these", "studies", "have", "firmly", "established", "Elf5", "as", "a", "crucial", "regulator", "of", "cell", "fate", "determination", "of", "epithelial", "tissues", ",", "there", "has", "been", "very", "limited", "information", "of", "the", "expression", "and", "function", "of", "Elf5", "in", "skin", "and", "HFs", "[", "10–12", "]", "and", "no", "knowledge", "if", "Elf5", "is", "involved", "in", "the", "activities", "of", "epidermal", "and", "HF", "stem", "cells", "(", "SCs", ")", "and", "their", "progenies", "." ] } ]
PMC11588085	Venn Diagram of common significantly up-regulated genes (Upper) and down-regulated genes (Bottom) in OVCAR3-KRAB with XIST KD (common genes between sgXIST7 and sgXIST9). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Venn", "Diagram", "of", "common", "significantly", "up-regulated", "genes", "(", "Upper", ")", "and", "down-regulated", "genes", "(", "Bottom", ")", "in", "OVCAR3-KRAB", "with", "XIST", "KD", "(", "common", "genes", "between", "sgXIST7", "and", "sgXIST9", ")", ".", "(" ] } ]
PMC5673955	β‐Gal expression levels in Jurkat and CD4 T cells cultivated with RrA. Levels of β‐Gal gene expression were normalized relative to the expression of reference gene 18S. (	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β‐Gal", "expression", "levels", "in", "Jurkat", "and", "CD4", "T", "cells", "cultivated", "with", "RrA.", "Levels", "of", "β‐Gal", "gene", "expression", "were", "normalized", "relative", "to", "the", "expression", "of", "reference", "gene", "18S", ".", "(" ] } ]
PMC11052306	It was shown, in particular, that the EPR signal is more intense in the presence of the HCT116 cancerous cells than in the presence of the MRC5 non-cancerous cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "It", "was", "shown", ",", "in", "particular", ",", "that", "the", "EPR", "signal", "is", "more", "intense", "in", "the", "presence", "of", "the", "HCT116", "cancerous", "cells", "than", "in", "the", "presence", "of", "the", "MRC5", "non-cancerous", "cells", "." ] } ]
PMC11449273	This may thus further explain the suppressive effects of plakoglobin on the colony formation/anchorage-independent growth of H1299-p53-175- and -273 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "This", "may", "thus", "further", "explain", "the", "suppressive", "effects", "of", "plakoglobin", "on", "the", "colony", "formation/anchorage-independent", "growth", "of", "H1299-p53", "-", "175-", "and", "-273", "cells", "." ] } ]
PMC11519077	Furthermore, as compared to the control group, the expression level of the NOD1 gene was considerably higher in the AD-CM group (1.46 ± 0.358; p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "as", "compared", "to", "the", "control", "group", ",", "the", "expression", "level", "of", "the", "NOD1", "gene", "was", "considerably", "higher", "in", "the", "AD-CM", "group", "(", "1.46", "±", "0.358", ";", "p", "<", "0.05", ")", "." ] } ]
PMC11806106	Both sensors were localized at the cell membrane and showed an agonist-induced FRET-change of about 6% (Supplementary Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "sensors", "were", "localized", "at", "the", "cell", "membrane", "and", "showed", "an", "agonist-induced", "FRET-change", "of", "about", "6", "%", "(", "Supplementary", "Fig.", "5", ")", "." ] } ]
PMC9429973	Hospital Universitari Germans Trias i Pujol; Red Blood Cell and Hematopoietic Disorders, ICO-Hospital Universitari Germans Trias i Pujol, Badalona, Spain Background: Next Generation Ektacytometry is up to now one of the best complementary diagnostic tool for hereditary rare anemias due to red cell defects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hospital", "Universitari", "Germans", "Trias", "i", "Pujol", ";", "Red", "Blood", "Cell", "and", "Hematopoietic", "Disorders", ",", "ICO-Hospital", "Universitari", "Germans", "Trias", "i", "Pujol", ",", "Badalona", ",", "Spain", "Background", ":", "Next", "Generation", "Ektacytometry", "is", "up", "to", "now", "one", "of", "the", "best", "complementary", "diagnostic", "tool", "for", "hereditary", "rare", "anemias", "due", "to", "red", "cell", "defects", "." ] } ]
PMC9429973	Significant unmet need exists in pts who were unable to derive the benefit from HDCT/HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "unmet", "need", "exists", "in", "pts", "who", "were", "unable", "to", "derive", "the", "benefit", "from", "HDCT/HSCT", "." ] } ]
PMC9429973	While research has been focused on high-risk patients, the biology of low-to-intermediate-risk patients has so far been inadequately investigated and can lead to overtreatment with severe side effects and under treatment with risk of relapse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "research", "has", "been", "focused", "on", "high-risk", "patients", ",", "the", "biology", "of", "low-to-intermediate-risk", "patients", "has", "so", "far", "been", "inadequately", "investigated", "and", "can", "lead", "to", "overtreatment", "with", "severe", "side", "effects", "and", "under", "treatment", "with", "risk", "of", "relapse", "." ] } ]
PMC6901583	g Wound healing assays were used to examine cell migration in GIST882 cells stably expressing vector or BRD4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Wound", "healing", "assays", "were", "used", "to", "examine", "cell", "migration", "in", "GIST882", "cells", "stably", "expressing", "vector", "or", "BRD4", "." ] } ]
PMC9429973	Aims: We retrospectively analyzed the phase 3 PERSIST-2 study, comparing pacritinib with ruxolitinib, with a focus on disease symptomatology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "retrospectively", "analyzed", "the", "phase", "3", "PERSIST-2", "study", ",", "comparing", "pacritinib", "with", "ruxolitinib", ",", "with", "a", "focus", "on", "disease", "symptomatology", "." ] } ]
PMC9429973	Here we are reporting 6 such rare complications of COVID immunization which was happened within 4days -42days following vaccination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "are", "reporting", "6", "such", "rare", "complications", "of", "COVID", "immunization", "which", "was", "happened", "within", "4days", "-42days", "following", "vaccination", "." ] } ]
PMC10482220	Error bars resulting from two independently performed experiments are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "resulting", "from", "two", "independently", "performed", "experiments", "are", "shown", "." ] } ]
PMC4277423	The latter detects heteroduplex formation of double stranded DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "latter", "detects", "heteroduplex", "formation", "of", "double", "stranded", "DNA", "." ] } ]
PMC11434983	Caution!	[ { "tags": [ "O", "O" ], "tokens": [ "Caution", "!" ] } ]
PMC10873328	TGFBI was further verified as a specific key target and demonstrated that its high expression was closely correlated with poor prognosis and chemoresistance of OC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGFBI", "was", "further", "verified", "as", "a", "specific", "key", "target", "and", "demonstrated", "that", "its", "high", "expression", "was", "closely", "correlated", "with", "poor", "prognosis", "and", "chemoresistance", "of", "OC", "." ] } ]
PMC11172027	Results: Both substances, NASeLM and NALM, were similarly able to inhibit cell growth and mitochondrial activity of Jurkat cells in a concentration-dependent and time-dependent manner up to 70%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Both", "substances", ",", "NASeLM", "and", "NALM", ",", "were", "similarly", "able", "to", "inhibit", "cell", "growth", "and", "mitochondrial", "activity", "of", "Jurkat", "cells", "in", "a", "concentration-dependent", "and", "time-dependent", "manner", "up", "to", "70", "%", "." ] } ]
PMC11684297	is visible or not.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "is", "visible", "or", "not", "." ] } ]
PMC11711935	Biorender was used to create the figures in the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biorender", "was", "used", "to", "create", "the", "figures", "in", "the", "study", "." ] } ]
PMC11286266	A DNA-plasmid encoding eGFP_cgATF6α_TEV_LD410-659_S12PMUT_AviTag_pCEFL_pu (UK3122) was introduced into CHO-K1 plain cells via Lipofectamine LTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "DNA-plasmid", "encoding", "eGFP_cgATF6α_TEV_LD410", "-", "659_S12PMUT_AviTag_pCEFL_pu", "(", "UK3122", ")", "was", "introduced", "into", "CHO-K1", "plain", "cells", "via", "Lipofectamine", "LTX", "." ] } ]
PMC11462673	A Volcano plot analysis revealed differentially expressed genes obtained from RNA-seq data between the LDB1 knockdown and the control groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Volcano", "plot", "analysis", "revealed", "differentially", "expressed", "genes", "obtained", "from", "RNA-seq", "data", "between", "the", "LDB1", "knockdown", "and", "the", "control", "groups", "." ] } ]
PMC10551595	For Bcl‐2, Bcl‐xL, XIAP‐BIR3 and cIAP1‐BIR3, their co‐crystallized ligands 1Y1, ABT‐737, X22, and 1Y0 were considered as control inhibitors, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "Bcl‐2", ",", "Bcl‐xL", ",", "XIAP‐BIR3", "and", "cIAP1‐BIR3", ",", "their", "co‐crystallized", "ligands", "1Y1", ",", "ABT‐737", ",", "X22", ",", "and", "1Y0", "were", "considered", "as", "control", "inhibitors", ",", "respectively", "." ] } ]
PMC10745221	Gels were incubated with ENHANCE (PerkinElmer Life Sciences, catalog #6NE9701) for 1 hour, incubated in water for 30 minutes, and dried before the gels were exposed to film (Denville Scientific, 8 X 10 in.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gels", "were", "incubated", "with", "ENHANCE", "(", "PerkinElmer", "Life", "Sciences", ",", "catalog", "#", "6NE9701", ")", "for", "1", "hour", ",", "incubated", "in", "water", "for", "30", "minutes", ",", "and", "dried", "before", "the", "gels", "were", "exposed", "to", "film", "(", "Denville", "Scientific", ",", "8", "X", "10", "in", "." ] } ]
PMC11423992	As depicted in Fig 1C, TFAB002s bound to both WIL2-S and Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "As", "depicted", "in", "Fig", "1C", ",", "TFAB002s", "bound", "to", "both", "WIL2-S", "and", "Jurkat", "cells", "." ] } ]
PMC9429973	The results were more pronounced after adjusting for demographic and clinical covariates (based on clinical opinion and literature review) and further assessed with a bivariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "were", "more", "pronounced", "after", "adjusting", "for", "demographic", "and", "clinical", "covariates", "(", "based", "on", "clinical", "opinion", "and", "literature", "review", ")", "and", "further", "assessed", "with", "a", "bivariate", "analysis", "." ] } ]
PMC9429973	Nonclassical monocytes and intermediary monocytes percentage decreased after COVID-19 infection (p=0,001 respective p=0,049), but intermediary monocytes show a higher level of HLA-DR expression (p=0,012) versus before infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonclassical", "monocytes", "and", "intermediary", "monocytes", "percentage", "decreased", "after", "COVID-19", "infection", "(", "p=0,001", "respective", "p=0,049", ")", ",", "but", "intermediary", "monocytes", "show", "a", "higher", "level", "of", "HLA-DR", "expression", "(", "p=0,012", ")", "versus", "before", "infection", "." ] } ]
PMC10568263	These samples were spiked with different HSP70 proteins (0, 0.1, 1, and 10 ng mL) to evaluate the accuracy and utility of the HSP70 immunosensor, as summarized in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "samples", "were", "spiked", "with", "different", "HSP70", "proteins", "(", "0", ",", "0.1", ",", "1", ",", "and", "10", "ng", "mL", ")", "to", "evaluate", "the", "accuracy", "and", "utility", "of", "the", "HSP70", "immunosensor", ",", "as", "summarized", "in", "Table", "2", "." ] } ]
PMC11607321	While further assessment is needed to substantiate this, more generally, it unveils the possibility of using MOSA as a holistic model that integrates molecular and phenotypic data of cancer cells to investigate cancer cell states, drug resistance and their underlying mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "further", "assessment", "is", "needed", "to", "substantiate", "this", ",", "more", "generally", ",", "it", "unveils", "the", "possibility", "of", "using", "MOSA", "as", "a", "holistic", "model", "that", "integrates", "molecular", "and", "phenotypic", "data", "of", "cancer", "cells", "to", "investigate", "cancer", "cell", "states", ",", "drug", "resistance", "and", "their", "underlying", "mechanisms", "." ] } ]
PMC9100622	However, in all three cell lines, we observed that Atorvastatin induced a decreased EdU incorporation, suggesting that this compound may induce a reduced incorporation of nucleotides during the S-phase (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "in", "all", "three", "cell", "lines", ",", "we", "observed", "that", "Atorvastatin", "induced", "a", "decreased", "EdU", "incorporation", ",", "suggesting", "that", "this", "compound", "may", "induce", "a", "reduced", "incorporation", "of", "nucleotides", "during", "the", "S-phase", "(", "Figure", "4B", ")", "." ] } ]
PMC9341513	Here, we calculated the fraction of simulated configurations where a given promoter is bound by a protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "calculated", "the", "fraction", "of", "simulated", "configurations", "where", "a", "given", "promoter", "is", "bound", "by", "a", "protein", "." ] } ]
PMC11453018	D Western blot analysis reveals for EWS::FLI1, P300, CBP, acH3K9, acH3K18 and acH3K27, in SKES1 and TC71 cell lines treated with 1 µM iP300w for 4 and 12 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Western", "blot", "analysis", "reveals", "for", "EWS::FLI1", ",", "P300", ",", "CBP", ",", "acH3K9", ",", "acH3K18", "and", "acH3K27", ",", "in", "SKES1", "and", "TC71", "cell", "lines", "treated", "with", "1", "µM", "iP300w", "for", "4", "and", "12", "hours", "." ] } ]
PMC11767725	Lifestyle interventions like weight loss have been associated with reductions in systemic inflammation and acne severity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lifestyle", "interventions", "like", "weight", "loss", "have", "been", "associated", "with", "reductions", "in", "systemic", "inflammation", "and", "acne", "severity", "." ] } ]
PMC10047551	Hyper-methylated CpG islands are potentially associated with transcriptional silencing of the corresponding gene, as exemplified by developmentally expressed genes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hyper-methylated", "CpG", "islands", "are", "potentially", "associated", "with", "transcriptional", "silencing", "of", "the", "corresponding", "gene", ",", "as", "exemplified", "by", "developmentally", "expressed", "genes", "." ] } ]
PMC10582049	Cluster 0 was assigned as FAPACTA2 CAFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "0", "was", "assigned", "as", "FAPACTA2", "CAFs", "." ] } ]
PMC11705067	The CCK-8 assay was performed to explore elesclomol-induced cuproptosis in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CCK-8", "assay", "was", "performed", "to", "explore", "elesclomol-induced", "cuproptosis", "in", "ccRCC", "." ] } ]
PMC11317131	HEK293, HEK293T and K562 cells were transfected with TransIT-2020 (Mirus Bio).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", ",", "HEK293", "T", "and", "K562", "cells", "were", "transfected", "with", "TransIT-2020", "(", "Mirus", "Bio", ")", "." ] } ]
PMC3730428	The assay was conducted in PBS in a total reaction volume of 50 μl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "was", "conducted", "in", "PBS", "in", "a", "total", "reaction", "volume", "of", "50", "μl", "." ] } ]
PMC11683240	From this cluster, the representative conformations were obtained using an RMSD cut-off of 2 Å, and its stability was evaluated by molecular dynamics simulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "this", "cluster", ",", "the", "representative", "conformations", "were", "obtained", "using", "an", "RMSD", "cut-off", "of", "2", "Å", ",", "and", "its", "stability", "was", "evaluated", "by", "molecular", "dynamics", "simulations", "." ] } ]
PMC9429973	Fifty (42.7%), 43 (36.8%), and 24 (20.5%) of patients received BSC, lower-intensity (AZA=31, AZA/VEN=4, LDAC=8) and higher-intensity chemotherapies (3 + 7=12, 1 + 5=7, 2 + 5=2, 3 + 5=1, 1 + 4=1) as front-line treatments, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fifty", "(", "42.7", "%", ")", ",", "43", "(", "36.8", "%", ")", ",", "and", "24", "(", "20.5", "%", ")", "of", "patients", "received", "BSC", ",", "lower-intensity", "(", "AZA=31", ",", "AZA/VEN=4", ",", "LDAC=8", ")", "and", "higher-intensity", "chemotherapies", "(", "3", "+", "7=12", ",", "1", "+", "5=7", ",", "2", "+", "5=2", ",", "3", "+", "5=1", ",", "1", "+", "4=1", ")", "as", "front-line", "treatments", ",", "respectively", "." ] } ]
PMC11766350	rAAV-TRAIL has been used successfully to induce tumor regression in mouse models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "rAAV-TRAIL", "has", "been", "used", "successfully", "to", "induce", "tumor", "regression", "in", "mouse", "models", "." ] } ]
PMC11394227	This result indicated that due to the ER’s enhanced folding and processing capacity in CHO-PAb-QS cells and the increased protein synthesis rate, there was an increased demand for vesicle transporters to transport mature proteins from the ER to the Golgi apparatus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "result", "indicated", "that", "due", "to", "the", "ER", "’s", "enhanced", "folding", "and", "processing", "capacity", "in", "CHO-PAb-QS", "cells", "and", "the", "increased", "protein", "synthesis", "rate", ",", "there", "was", "an", "increased", "demand", "for", "vesicle", "transporters", "to", "transport", "mature", "proteins", "from", "the", "ER", "to", "the", "Golgi", "apparatus", "." ] } ]
PMC9688728	However, the scientific community already widely accepted that metabolomic knowledge is a real “Klondike” for understanding normal and pathological molecular processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "scientific", "community", "already", "widely", "accepted", "that", "metabolomic", "knowledge", "is", "a", "real", "“", "Klondike", "”", "for", "understanding", "normal", "and", "pathological", "molecular", "processes", "." ] } ]
PMC11708541	Patients' monoamine oxidase (MAO) activity was considerably (P < 0.01) higher than the control groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "'", "monoamine", "oxidase", "(", "MAO", ")", "activity", "was", "considerably", "(", "P", "<", "0.01", ")", "higher", "than", "the", "control", "groups", "." ] } ]
PMC9429973	No patient had fatal adverse events(Table2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "had", "fatal", "adverse", "events(Table2", ")", "." ] } ]

PMC11060216

The expression of the biomarkers was graded according to the standard as follows: <25% positive cells, 1; 26–50% positive cells, 2; 51–75% positive cells, 3; >76% positive cells, 4.

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PMC11155445

Several comprehensive reviews and compilation reports authored by Koch, Aly, and Saeed have systematically examined the literature pertaining to N-substituted-N-aroyl(acyl)thiourea chemistry.

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PMC11306331

Negative values indicate condensate disruption.

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PMC11548041

Single color controls included (1) DiO-stained MNVs, (2) unstained MNVs functionalized with 0.1 μM Cy5-aptamer-TEGChol, as well as a (3) dye only control consisting of 5 μM vibrant DiO in PBS that underwent ultracentrifugation and was resuspended in PBS.

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PMC10975211

Selenium compounds can potentially slow cancer cell development and trigger apoptosis in cancer cell culture models .

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PMC11127909

Mitochondrial drug delivery systems are still immature and need further research.

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PMC7022782

Furthermore, during this study, we evaluated if the dye-loading process could improve the aqueous stability of ICG.

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PMC9960565

By adapting previous methodologies , two different procedures were implemented to conjugate cisplatin to the anionic PAMAM dendrimers.

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PMC11519583

d Expression of Wnt11 in isolated MPs treated with the indicated siRNAs was assessed using quantitative RT-PCR analysis (n = 3).

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PMC9429973

After two courses of R-ESHAP no response was achieved and Tisagenlecleucel was administrated on April 2021.

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PMC6133382

Digested peptides were desalted and purified by passing through a C18 sep-pak cartridge after inactivating trypsin by heating at 95 °C for 5 minutes.

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PMC10891340

We explored which stage of DPV life cycle was suppressed upon CCCP treatment.

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PMC6190245

Apoptosis assessed by flow cytometry The apoptotic cells were detected by propidium iodide (PI) staining.

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PMC11409031

≤0.001.

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PMC11679033

This overlap raises concerns about potential CBD-CIT interactions in patients treated with CBD therapeutics .

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PMC11387401

Beside proteins, host RNA molecules are reported to aid HIV-1 replication and latency maintenance.

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PMC11740207

Given the morphological similarities among hypothetical developmental stages, we have divided the scatter dot plot’s region of interest into two distinct events: VSLSLCs and small LSLCs (SLSLCs).

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PMC11779960

During malignant transformation, assuming the malignancy arose from a single mature T cell, the resulting lymphoma should homogenously and exclusively express only one TRBC chain.

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PMC6600253

Previous studies have indicated that G-quadruplexes obstruct telomerase activity and telomere extension .

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PMC11572213

quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm downregulation of TET2 expression.

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PMC10178190

CM incubation variably affected pERK1/2, depending upon the cell line tested and the source of the CM.

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PMC9681981

After 5 min incubation at room temperature, 1 μL of M-MuLV reverse transcriptase enzyme was added and mixed.

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PMC11534377

To investigate the effect of 5-Aza on lung cancer we treated four lung cancer cell line models with increasing doses of 5-Aza.

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PMC6461034

For faithful aliquoting of equal amounts of beads, it is essential to apply a stepwise strategy: invert the “stock” vial with beads 10 times and distribute a fraction (e.g., 1/4) of the “stock” to the “IP” tubes—restore the volume of the “stock” vial with IP buffer; perform a second distribution round by again distributing (only) a fraction of the “stock” and restoring the volume of the “stock” vial with IP buffer, etc.;

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PMC9111184

Hydroxycinnamic acid derivatives and EZ were added simultaneously with cholesterol to the apical compartment of the transwells.

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PMC9847912

In three independent assay runs, the IC50 value for the M3 mutant was 1.8 ± 0.90 nM (mean ±1 standard deviation).

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PMC9429973

Results: Patients were divided into the four prognostic groups proposed by the CLL-IPI as follows: 6 (17.2%) at low risk, 16 (45.7%) at intermediate risk, 10 (28.6%) at high risk, and 3 (8.6%) at very high risk.

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PMC11087301

SOX2 functions as a stem cell TF that maintains CSC properties.

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PMC9739791

Due to non-specific binding to biomolecules, all three FDA-approved platinum drugs exhibit acute toxicity to various organs, including nephrotoxicity , ototoxicity , and neurotoxicity .

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PMC6642070

Insert is the average normalized to control in baseline. (

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PMC6889484

Replication kinetics from duplicate flasks are indicated. (

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PMC9429973

Primary EMD is found in newly diagnosed MM (NDMM) patients.

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PMC11742047

A total of 1432 and 501 possible compounds was found using LC–MS in both ionization modes.

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PMC11413393

Mini-Turbo plasmid (pSTV6-N-miniTurbo-BirA) was obtained as a gift from Dr. Brian Raught’s lab.

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PMC11549062

Vulnerable plaques, featured by a large necrotic core with a high content of lipids and inflammatory cells, are covered by a thin fibrous cap, whereas stable plaques are represented with thick fibrous caps with vascular smooth muscle cells (VSMCs) producing extracellular matrix .

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PMC11055443

Chenari et al. also indicated that MSCs modulate the inflammatory responses to BCG infection and decrease the secretion of TNF-α and IL-1β in the alveolar fluid.

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PMC11594641

Moreover, exploring the targeting of Rab27 in combination with other proteins involved in sEV secretion, such as TSG101, could additionally improve the therapeutic outcome and become a novel strategy for preventing melanoma progression and metastasis.

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PMC11634794

Following a 14-day incubation period, the cells were fixed with 75% methanol and stained with 0.1% crystal violet.

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PMC11786704

Current research shows that the MAPK signaling pathway plays a complex and diverse role in inflammation and apoptosis.

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PMC11680391

However, our analysis demonstrated a wide variation in opinion about the communication between farmers and their veterinarians during udder health consulting.

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PMC6461034

The PhosphoSitePlus‐ and NetworKIN‐based approaches depend on the availability of comprehensive curated data on experimentally observed kinase–substrate relationships or reliable predictions thereof, respectively.

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PMC9429973

S. Molica, C. Patti, P. Sportoletti, A. Chiarenza, A. M. Giordano, F. Chiurazzi, N. Di Renzo, P. Musto, F. Pane, F. Di Raimondo, L. Trentin, F. R. Mauro, D. Giannarelli Department Hematology, Hull University Teaching Hospitals NHS Trust, Hull, UK, Hall, United Kingdom; hematology, Ospedale Cervello, Palermo; Hematology Unit, University Perugia, Perugia; Hematology Unit, Ferrarotto Hospital, Catania; 5Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari; Department of Clinical Medicine and Surgery, Hematology Unit, Federco II Medical School Napoli, Napoli; Hematology Unit, Presidio Ospedaliero Vito Fazi, Lecce; Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari; Department of Clinical Medicine and Surgery, Hematology Unit, Federico II Medical School Napoli, Napoli; Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua; Hematology, Department of Translational and Precision Medicine, Sapienza University Rome; Biostatistic Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Rome, Italy Background: Changes in the treatment landscape of CLL have complicated the decision-making processes, especially in the context of relapsed/refractory (R/R) disease.

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PMC9429973

The decrease in the number of colony-forming cells of granulomonocytopoiesis was distinct in cell suspension samples stored for more than 10 months, but also did not reach significant values: 64%, 58% and 37%, respectively; p=0.451.

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PMC11279598

To assess the effects of Manuka honey, we treated MCF-7 cells for 24 h with control or Manuka honey at 0.6%, 1.25%, 2.5%, or 5.0% (w/v).

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PMC11680562

This combination could promote adherence to the vaginal mucosa and sustain the release of the drug and metal NPs at the cervical region.

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PMC10421378

To visualize the morphology of the dried powder microparticles, selected samples were analyzed using scanning electron microscopy.

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PMC11599565

These morphological changes correlate with the expression of a plethora of neuronal-defining markers.

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PMC11742290

Although the trial was terminated, there was evidence that BNC101 could infiltrate the CRC patient tumor and engage with overexpressed LGR5 receptors .

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PMC11532793

Plots showing the observed power and the observed false discovery rate (FDR) versus the number of replicate samples while controlling for different nominal FDR levels.

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PMC10203589

Although the same therapies can effectively improve overall survival (OS) in these patients, understanding the molecular mechanisms of their pathogenesis and identifying new therapeutic targets are still urgently needed.

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PMC9429973

There were no clinically significant changes in laboratory parameters or vital signs, no injection site reactions, serious adverse events, or deaths.

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PMC11757230

As previously reported , cADSCs were confirmed for distinctive surface marker expression patterns (CD29, CD44, and CD90 positive; CD34, CD45, and HLA-DR negative) and tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis).

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PMC11499381

The resulting constructs were transfected into Cos7 and HEK293S cells, where we measured cAMP production in response to ligand stimulation, cell surface expression of receptor complexes, and BiFC fluorescence.

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PMC11727145

The 4 °C storage protocol was thus used for all experiments presented herein.

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PMC11697189

Right semicircle green, prognostic protective factors; Right semicircular purple, prognostic risk factors.

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PMC11698348

While these studies have firmly established Elf5 as a crucial regulator of cell fate determination of epithelial tissues, there has been very limited information of the expression and function of Elf5 in skin and HFs [10–12] and no knowledge if Elf5 is involved in the activities of epidermal and HF stem cells (SCs) and their progenies.

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PMC11588085

Venn Diagram of common significantly up-regulated genes (Upper) and down-regulated genes (Bottom) in OVCAR3-KRAB with XIST KD (common genes between sgXIST7 and sgXIST9). (

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PMC5673955

β‐Gal expression levels in Jurkat and CD4 T cells cultivated with RrA. Levels of β‐Gal gene expression were normalized relative to the expression of reference gene 18S. (

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PMC11052306

It was shown, in particular, that the EPR signal is more intense in the presence of the HCT116 cancerous cells than in the presence of the MRC5 non-cancerous cells.

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PMC11449273

This may thus further explain the suppressive effects of plakoglobin on the colony formation/anchorage-independent growth of H1299-p53-175- and -273 cells.

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PMC11519077

Furthermore, as compared to the control group, the expression level of the NOD1 gene was considerably higher in the AD-CM group (1.46 ± 0.358; p < 0.05).

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PMC11806106

Both sensors were localized at the cell membrane and showed an agonist-induced FRET-change of about 6% (Supplementary Fig. 5).

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PMC9429973

Hospital Universitari Germans Trias i Pujol; Red Blood Cell and Hematopoietic Disorders, ICO-Hospital Universitari Germans Trias i Pujol, Badalona, Spain Background: Next Generation Ektacytometry is up to now one of the best complementary diagnostic tool for hereditary rare anemias due to red cell defects.

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PMC9429973

Significant unmet need exists in pts who were unable to derive the benefit from HDCT/HSCT.

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PMC9429973

While research has been focused on high-risk patients, the biology of low-to-intermediate-risk patients has so far been inadequately investigated and can lead to overtreatment with severe side effects and under treatment with risk of relapse.

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PMC6901583

g Wound healing assays were used to examine cell migration in GIST882 cells stably expressing vector or BRD4.

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PMC9429973

Aims: We retrospectively analyzed the phase 3 PERSIST-2 study, comparing pacritinib with ruxolitinib, with a focus on disease symptomatology.

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PMC9429973

Here we are reporting 6 such rare complications of COVID immunization which was happened within 4days -42days following vaccination.

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PMC10482220

Error bars resulting from two independently performed experiments are shown.

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PMC4277423

The latter detects heteroduplex formation of double stranded DNA.

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PMC11434983

Caution!

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PMC10873328

TGFBI was further verified as a specific key target and demonstrated that its high expression was closely correlated with poor prognosis and chemoresistance of OC.

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PMC11172027

Results: Both substances, NASeLM and NALM, were similarly able to inhibit cell growth and mitochondrial activity of Jurkat cells in a concentration-dependent and time-dependent manner up to 70%.

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PMC11684297

is visible or not.

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PMC11711935

Biorender was used to create the figures in the study.

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PMC11286266

A DNA-plasmid encoding eGFP_cgATF6α_TEV_LD410-659_S12PMUT_AviTag_pCEFL_pu (UK3122) was introduced into CHO-K1 plain cells via Lipofectamine LTX.

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PMC11462673

A Volcano plot analysis revealed differentially expressed genes obtained from RNA-seq data between the LDB1 knockdown and the control groups.

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PMC10551595

For Bcl‐2, Bcl‐xL, XIAP‐BIR3 and cIAP1‐BIR3, their co‐crystallized ligands 1Y1, ABT‐737, X22, and 1Y0 were considered as control inhibitors, respectively.

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PMC10745221

Gels were incubated with ENHANCE (PerkinElmer Life Sciences, catalog #6NE9701) for 1 hour, incubated in water for 30 minutes, and dried before the gels were exposed to film (Denville Scientific, 8 X 10 in.

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PMC11423992

As depicted in Fig 1C, TFAB002s bound to both WIL2-S and Jurkat cells.

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PMC9429973

The results were more pronounced after adjusting for demographic and clinical covariates (based on clinical opinion and literature review) and further assessed with a bivariate analysis.

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PMC9429973

Nonclassical monocytes and intermediary monocytes percentage decreased after COVID-19 infection (p=0,001 respective p=0,049), but intermediary monocytes show a higher level of HLA-DR expression (p=0,012) versus before infection.

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PMC10568263

These samples were spiked with different HSP70 proteins (0, 0.1, 1, and 10 ng mL) to evaluate the accuracy and utility of the HSP70 immunosensor, as summarized in Table 2.

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PMC11607321

While further assessment is needed to substantiate this, more generally, it unveils the possibility of using MOSA as a holistic model that integrates molecular and phenotypic data of cancer cells to investigate cancer cell states, drug resistance and their underlying mechanisms.

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PMC9100622

However, in all three cell lines, we observed that Atorvastatin induced a decreased EdU incorporation, suggesting that this compound may induce a reduced incorporation of nucleotides during the S-phase (Figure 4B).

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PMC9341513

Here, we calculated the fraction of simulated configurations where a given promoter is bound by a protein.

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PMC11453018

D Western blot analysis reveals for EWS::FLI1, P300, CBP, acH3K9, acH3K18 and acH3K27, in SKES1 and TC71 cell lines treated with 1 µM iP300w for 4 and 12 hours.

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PMC11767725

Lifestyle interventions like weight loss have been associated with reductions in systemic inflammation and acne severity .

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PMC10047551

Hyper-methylated CpG islands are potentially associated with transcriptional silencing of the corresponding gene, as exemplified by developmentally expressed genes .

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PMC10582049

Cluster 0 was assigned as FAPACTA2 CAFs.

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PMC11705067

The CCK-8 assay was performed to explore elesclomol-induced cuproptosis in ccRCC.

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PMC11317131

HEK293, HEK293T and K562 cells were transfected with TransIT-2020 (Mirus Bio).

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PMC3730428

The assay was conducted in PBS in a total reaction volume of 50 μl.

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PMC11683240

From this cluster, the representative conformations were obtained using an RMSD cut-off of 2 Å, and its stability was evaluated by molecular dynamics simulations.

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PMC9429973

Fifty (42.7%), 43 (36.8%), and 24 (20.5%) of patients received BSC, lower-intensity (AZA=31, AZA/VEN=4, LDAC=8) and higher-intensity chemotherapies (3 + 7=12, 1 + 5=7, 2 + 5=2, 3 + 5=1, 1 + 4=1) as front-line treatments, respectively.

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PMC11766350

rAAV-TRAIL has been used successfully to induce tumor regression in mouse models .

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PMC11394227

This result indicated that due to the ER’s enhanced folding and processing capacity in CHO-PAb-QS cells and the increased protein synthesis rate, there was an increased demand for vesicle transporters to transport mature proteins from the ER to the Golgi apparatus.

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PMC9688728

However, the scientific community already widely accepted that metabolomic knowledge is a real “Klondike” for understanding normal and pathological molecular processes.

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PMC11708541

Patients' monoamine oxidase (MAO) activity was considerably (P < 0.01) higher than the control groups.

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PMC9429973

No patient had fatal adverse events(Table2).

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