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OTAR3088
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PMC11704135
Pyrimidine derivatives have gained significant attention in the field of medicinal chemistry due to their diverse biological activities, including antimicrobial properties.
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PMC3765139
indicates percentages of positive gated cells <1%.
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PMC11045125
In contrast, only 25–40% of BLs in western countries are EBV-positive .
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PMC11442172
Metabolic rewiring is a defining characteristic of cancer cells, driving their ability to proliferate.
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PMC11700247
In summary, these results validate that the combination of RT with CART-19 promotes the crosspresentation of TAAs, thereby eliciting an additional autologous T-cell immune response that enhances the antitumor efficacy of CART-19 therapy when administered in combination with RT.Figure 4.Enhanced tumor protection in a colorectal model through adoptive transfer of CD3 T cells from mice treated with RT plus CART-19. (
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PMC11753435
In comparison, RFDiffusion reports around 2 min for the design of a single binder (17).
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PMC10376064
To meet the need for novel therapeutics, existing drugs with additional preferred pharmacological profiles could be recruited.
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PMC11267036
Below were the primers used: STAT1 forward, 5′-TCA GGC TCA GTC GGG GAA TA-3′ and reverse, 5′-ATC ACT TTT GTG TGC GTG CC-3′; RIG-I forward, 5′-CTG GTT CCG TGG CTT TTT GG-3′ and reverse, 5′-AGC AGG CAA AGC AAG CTC TA-3′; GAPDH forward, 5′-TGT GGG CAT CAA TGG ATT TGG-3′ and reverse, 5′-ACA CCA TGT ATT CCG GGT CAA T-3.
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PMC4277423
Importantly, using T7 endonuclease I assay we did not detect genome mutations at potential off-target sites that are highly homologous to these CCR5 sgRNAs in stably transduced cells even at 84 days post transduction.
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PMC10243817
However, siTGFBR3 treatment only abolished TGF-β2–induced, but not TGF-β1–induced, SMAD2 phosphorylation in ALI-cultured HNECs (Figure 5D and Supplemental Figure 9C).
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PMC9872547
PEGylated dendrosomes as nano-carriers were prepared according to the previously optimized protocol (7).
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PMC11506670
No. CB1001; Calbiochem, San Diego, CA, USA).
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PMC9429973
P. Delaporta, E. Terpos, E. E. Solomou, S. Gumeni, M.-I. Chatzielefteriou, K. Toutoudaki, D. Kyriakopoulou, N. Ioakeimidou, I. Ntanasis-Stathopoulos, I. Papassotiriou, I. P. Trougakos, M. A. Dimopoulos, A. Kattamis Thalassemia Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Agia Sophia Children Hospital; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens; Department of Cell Biology and Biophysics, Faculty of Biology; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens; Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital; Department of Cell Biology and Biophysics, Faculty of Biology; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens; Thalassaemia Unit, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece Background: Patients with transfusion-dependent-thalassaemia (TDT) are considered as increased risk population for severe and/or morbid COVID-19 infection.
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PMC6182045
Additionally, unreduced CHO-S derived TZ97008 rgp120 displayed a faint band at ~200 kDa (Figure 6C), indicative of a small dimerized fraction not present in purified 3E5 MGAT1 CHO derived rgp120 samples.
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PMC11724582
The cell density was adjusted to 2.5 × 10/mL. The cell suspension (200 µL) was introduced into the upper chamber of a Transwell insert, whereas medium supplemented with 10% FBS was added to the lower chamber.
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PMC11806182
For each chemical, three replicates were performed in control and treatment groups .
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PMC11377827
However, some USP43 localised within the nucleus, and this was markedly increased in hypoxia (Fig. 5A,B).
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PMC7757104
Subsequent experiments were performed following the selection or A2780 OPNc cell line in selection culture media.
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PMC11761919
The target bands were visualized using the ECL Chemiluminescence Detection Kit (P0018S) (Beyotime, Shanghai, China) according to the manufacturer's instructions.
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PMC10994876
A stable erythropoietin-producing CHO-K1 cell line (EPO-CHO) had previously been developed and generated in our laboratory.
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PMC11194678
In each batch, at least 200 fluorescence-positive cells were counted for each group of experiments.
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PMC11345828
AUC is dose normalized.
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PMC11747949
Importantly, CXCL8 and VEGF were shown to be increased in the blood serum of patients with osteosarcoma (Jiang et al. 2017).
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PMC11615828
To spatiotemporal perturb synaptic vesicle transmission, several studies used optogenetic tools to cluster synaptic vesicles, which results in inhibition of synaptic vesicle release. ,
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PMC6600592
Results also revealed that oximes were weaker in inhibiting HBV, and more cytotoxic than their relative ethers; meanwhile, methyl ethers were the most active in inhibiting HBV among compounds in every group.
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PMC9429973
However, less than half of patients achieve long-term remission, with treatment-associated adverse events a clinical challenge.
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PMC4270159
A. Loading control.
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PMC9429973
Eight patients, all with EN involvement (3 sinus/nasal cavity, 2 breast, 2 bone and 1 orbit), received CNS prophylaxis.
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PMC11612794
Left: Mis12C is shown as a cartoon and color-coded, as indicated in the figure.
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PMC11700247
Data are representative of 2 independent experiments.
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PMC11694066
The homogenate was passed through a 100-μm cell strainer (#542000, Greiner Bio-One) to remove debris and cell clumps, and the cell suspension was then centrifuged for 10 minutes at 450g. After aspiration of the supernatant, the cell pellet was resuspended in 1 mL of the abovementioned blocking medium.
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PMC9429973
F. Kammoun, Y. Fakhfakh, M. Charfi, O. Kassar, M. Chaari, L. Bouaoun, M. Bahloul, I. Frikha, F. Kallel, I. Ben Amor, L. Khalifa, M. Medhafar, S. Hadiji, H. Elleuch, H. Mnif, M. Bouaziz, M. Elloumi Clinical Hematology Depatment; Biological Hematology Department, Hedi Chaker Hospital; Plasmapheresis Unit, Regional Blood Transfusion Center; Medical Reanimation Department, Habib Bourguiba Hospital, Sfax, Tunisia Background: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumption thrombocytopenia, and organ injury.
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PMC9429973
Further analysis confirmed a higher percentage of myeloid-derived suppressor cells in the PBMCs of HI donors that, in in vitro EBV-LCL co-cultures, prevented memory CTL proliferation.
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PMC11509278
This metabolic process is also present in prostate cancer .
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PMC11574271
In vitro, RON activation resulted in increased bladder cancer cell migration and invasiveness.
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PMC3019555
Endogenous miRNA expression was assessed by qRT-PCR in HeLa cells after overnight treatment with 25 nM TX or 25 µM 2ME2.
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PMC11706776
Samples were then incubated with appropriate antibody diluted at 1:50 in blocking solution for 1 h at room temperature.
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PMC7709199
The final yield of purified CSF-1RD1–D3 was reduced to about 2 mg per litre of culture, which is still enough to allow extensive screening of crystallization conditions.
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PMC11665555
We demonstrated the stem marker and fatty acid receptor CD36 to be upregulated by OXCT1.
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PMC9429973
Methods: In this cohort study 2,937 individuals aged 18-40 years with a recorded diagnosis of cHL in the Swedish lymphoma register (SLR), the Danish lymphoma registry (LYFO), or the clinical database at Oslo University Hospital (OUH) between 1995 and 2019 were included.
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PMC11577421
Therefore, we sought to address this gap before evaluating NP-GAG interactions and NP uptake.
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PMC9429973
A. M. Shahid, M. Elshani, D. J. Harrison School of Medicine, University of St Andrews, St Andrews, United Kingdom Background: NUC-7738, a phosphoramidate transformation of 3’deoxyadenosine (3’dA), is specifically designed to generate the active anti-cancer metabolite 3’-deoxyadenosine triphosphate (3’-dATP) directly in cells, bypassing key cancer resistance mechanisms of transport, activation and breakdown.
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PMC11682525
The relative expression of key genes was evaluated using qRT-PCR.
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PMC11682172
The fraction of cancer cells not silenced for CORO1A (siSham) are taken as fraction = 1.
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PMC11301095
He initially experienced unprovoked fever three days prior to hospitalization, peaking at 39.6 ℃, and was accompanied by dizziness and headache.
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PMC11697703
S.T. is a Tashia and John Morgridge Endowed Faculty Scholar in Pediatric Translational Medicine of the Stanford Maternal and Child Health Research Institute.
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PMC9429973
50% of ophthalmologists increased in and 46% maintained confidence.
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PMC8633974
pLenti-CRISPR-RFP657 plasmid (1.08 μg) was diluted in 81 μL OptiMEM, then supplemented with 3.24 μL TransIT®-Jurkat transfection reagent.
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PMC6442998
The development of a new compound for clinical use is a lengthy, costly process with a very low success rate.
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PMC11742431
Therefore, based on the advantages of the above studies, we designed the BumPeD system for the targeted degradation of Survivin protein in PD‐L1 high‐expressing cells.
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PMC11802929
e Pep-UMAP with densities of PG1-3 depicted, legend on the bottom.
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PMC11632064
Cytoscape visualization of significantly enriched gene sets in A-375 cells treated with LJH685 for 72 h compared to DMSO. (
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PMC11001582
NS denotes P > 0.05.
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PMC11413393
Cells were again washed 3 times with ice cold PBS and then permeabilized with two different blocking buffers: for Anti-phospho-Histone H2A.X (Ser139)—5% BSA, 10% FBS, 0.25% Triton X-100, 1% fish skin gelatin in PBS; and for FANCD2—5% Normal Goat Serum, 0.3% Triton X-100, 1% BSA in PBS.
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PMC11748618
Large-scale host knockout studies have identified hundreds of HIV host dependency and restrictions factors.
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PMC9917080
U373 and U87 glioblastoma cells were treated with various concentrations of sorafenib, and only 48 h later apoptosis induction was recorded in the concentration range ≥5 μg/mL. Whereas in our experiments, the induction of the early stages of apoptosis was recorded already at a SeSo nanocomplex concentration of 1 μg/mL. For sorafenib, an increase in the proapoptotic effect was also shown under the action of tumor-treating fields (electric fields with alternating low and intermediate intensity), when after 48 h there was a significant increase in the number of cells in the early stages of apoptosis , which we also observed under the action of sorafenib, as part of a nanocomplex with selenium.
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PMC9895440
After 24 h of resting at 37 °C, the cells were co-incubated with T2 wt or T2 KO cells at an E:T ratio of 1:2 in presence of 100 nM NY-ESO-1 9 V peptide.
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PMC10772747
The cells were incubated for 24 hours with EBE treatment, 1,4-naphthoquinone (Sigma-Aldrich, USA) (50–500 µM), and doxorubicin (DOX) (Sigma-Aldrich, USA) (0.01–10 µM).
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PMC11543853
Scale bars 100 nm.
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PMC11641630
M. bovis BCG infection reduces FGFR3 expression in BC cells, potentially explaining the reduced anchorage-independent growth observed in our experiments .
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PMC11266100
Reported electrotransfection efficacy results of GFP-encoding plasmid with the CHO-K1 cell line and standard microsecond EP protocol are in good agreement with existing knowledge (Chopinet et al., 2013; Novickij et al., 2020).
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PMC8557138
Another approach, stereolithography, which involves the cross-linking of photosensitive polymers using ultraviolet light can be used to create perfusable channels by embedding a sacrificial filament network on a matrix consisting of cells.
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PMC11742431
Measurement of tumor volumes showed that either the KVN or K14N protein significantly inhibited tumor growth, and there was no difference between the KVN‐treated and K14N‐treated groups (Figure 7C).
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PMC11751675
This interest has led to many studies regarding the isolation of these compounds from natural sources, the development of semi-synthesis methodologies, and the evaluation of the pharmacological potential of SLs and their derivatives.
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PMC11635087
Although several studies introduced isolated chloroplasts into the cells of different species, their photosynthetic activities have not been confirmed.
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PMC11795610
These results showed that myricetin promoted keratinocyte differentiation, which might be related to the TRPV4-mediated Ca influx.
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PMC9429973
Of note, 1 pt received selinexor plus lenalidomide based regimen and obtained a prolonged disease control.
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PMC9429973
Metabolic studies disclosed that BCAAs oxidation is decreased following NOTCH1 inhibition (reduction in 3-methyl-2 oxovaleric acid).
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PMC9429973
Of these, within the reference values - 55.0% of patients.
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PMC11791432
As shown in Fig. 6C&Supply Table 2, EdU staining showing proliferating cells was significantly fewer in shANXA1 groups in both cell lines.
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PMC11098378
Membranes were blocked in Odyssey Blocking Buffer (LI-COR; S4 Table) for 1 h at 25°C.
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PMC10975211
Non-communicable illnesses are becoming a widespread global public health issue.
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PMC4270159
A lab from the Science Exchange network with extensive experience in conducting Western blot assays for phosphorylated proteins will perform these experiments.
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PMC6771295
In summary, in most cases, where significant effects were detected, SIRT1, SIRT3, and SIRT5 had positive effects on beclin-1 and LC3II/LC3I ratio, except in REN etoposide treated cells, where SIRT1 had negative effect on LC3II/LC3I ratio.
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PMC11650848
We have previously reported that this CpG-rich region at ZFP57 was one of the top DMR in cord blood from newborns whose mothers had participated in a randomised controlled trial (RCT) of Folic Acid Supplementation during the Second and Third Trimester (FASSTT) of pregnancy .
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PMC11343332
Real-time PCR was performed on a CFX96 PCR system (Biorad).
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PMC7039683
Next, we applied machine-learning classifier to zebrafish periderm enhancer candidates and used it to test the prediction that zebrafish periderm enhancers are enriched for the same sequence motifs as their mammalian counterparts.
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PMC7519871
Significantly effective treatments compared to untreated control (shown as #) are indicated as ** (P<0.005) and *** (P<0.0005).
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PMC9429973
The ROC curve analyses found the optimal cut-off value to discriminate between Gas5high and GAS5low.
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PMC11705862
Quantifications for each protein, based on eight biological repeats, are presented in (C, D and E), respectively.
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PMC7185206
786–0 renal carcinoma cells produced copious sPD-L1 in vitro at high cell titers and on interferon-γ treatment, but an inhibitor of ADAM10 and ADAM17 reduced measurable supernatant sPD-L1 (Figure 2(a), Supplemental Table 3).
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PMC11345828
Importantly it is in such a scenario where inhibition of Mcl-1 may have the strongest therapeutic benefit.
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PMC11788920
The expected RNA transcripts corresponding to these stalls are listed on the right (under (C)). (
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PMC9429973
Results: Results for this study are not yet available: outcome data as described above will be presented in due course.
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PMC11201245
Three times the standard deviation is added to the mean value found, resulting in the cut-off value of 36% for the OC-FISH test.
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PMC7840816
The specific primers used were as follows: SOX9, 5′-TGCTCAAGGGCTACGACTG-3′ (sense) and 5′-ACGCTTCTCGCTCTCATTCA-3′ (antisense); β-actin, 5′-CTCCATCCTGGCCTCGCTGT-3′ (sense) and 5′-GCTGTCACCTTCACCGTTCC-3′ (antisense).
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PMC7812570
C Expression of CD4, CCR5, or CXCR4 on the surface of transduced CEMss-CCR5 cells, as evaluated by measuring the fluorescence intensity To evaluate the inhibitory activities of GPI-m36.4 and GPI-FluIgG03, transduced CEMss-CCR5 cells were first infected with two CXCR4-tropic strains (NL4-3 and SG3.1) and then cultured in complete DMEM for 9 or 11 days.
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PMC11739504
In serum starvation 12 h and 24 h, two panels were displayed depending on presence of primary cilia NIH/3T3 cells were transfected with expressing GFP-tagged full-length-Kat2b.
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PMC11434983
The experiments were performed in triplicate.
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PMC11467964
The infiltration abundance of many immune cells was higher in the low‐risk group, especially B cells naive, monocytes, macrophages, dendritic cells resting, and mast cells resting.
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PMC9429973
Symptoms evolve from a non-aggressive “low-risk” (LR) clinical form to an aggressive and treatment-resistant “high-risk” (HR) form.
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PMC11591038
It is imperative to understand the mechanisms inherent in the microbiota–gut–brain axis so that microbe-based intervention and therapeutic strategies may be developed for neurodegenerative diseases .
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PMC6835428
As in the SC approach, cells do not metastasize, this model is not suited to the study of ovarian metastasis.
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PMC11666785
Irrespective of the single molecule detection algorithm these noises are also detected as molecules and contribute to the reconstructed image, affecting both the image resolution and further quantitative analysis.
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PMC11438317
Although the evidence supporting this association is compelling, the mechanism underlying the contribution of LYP to autoimmune diseases has been elusive.
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PMC9429973
Summary/Conclusion: Stem cell transplant is still not feasible to all leigable candidates due to shortage of facilities and trained personnel especially in developing countries.
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PMC11773391
As shown in Figure 5A, with increasing TMZ concentration and application time, the inhibition rates of A375 and SK‐MEL28 cells gradually increased.
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PMC11190538
The sample was then centrifuged for 30 min at 4 °C at 15,000×g (Eppendorf centrifuge 5804 R, Hamburg, Germany).
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PMC11033180
Scale bars, A: 30 μm; C–I: 15 μm.
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PMC4360730
A number of tools exist to map a set of specific annotations up to the corresponding set of GO slim terms, a process called slimming, including the web-based AmiGO (http://amigo1.geneontology.org/cgi-bin/amigo/slimmer) and command-line owl tools (https://code.google.com/p/owltools/).
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