Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11519583
We further found that MP proliferation and IMAT accumulation are promoted when both signaling pathways are activated simultaneously in MPs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "found", "that", "MP", "proliferation", "and", "IMAT", "accumulation", "are", "promoted", "when", "both", "signaling", "pathways", "are", "activated", "simultaneously", "in", "MPs", "." ] } ]
PMC10040136
According to our findings, MSC are capable of inducing drug resistance in GIST cells via the secretion of TGF-β2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "our", "findings", ",", "MSC", "are", "capable", "of", "inducing", "drug", "resistance", "in", "GIST", "cells", "via", "the", "secretion", "of", "TGF-β2", "." ] } ]
PMC11347429
Multiple testing adjusted P values were calculated according to Benjamini and Hochberg (44).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "testing", "adjusted", "P", "values", "were", "calculated", "according", "to", "Benjamini", "and", "Hochberg", "(", "44", ")", "." ] } ]
PMC9429973
Image: Summary/Conclusion: A progressive dose increase, based on molecular response, in elderly CML patients treated with second-line bosutinib produced high response rates; few patients required a dose increase to 400 mg, while most pts remained on 300 mg or less.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "A", "progressive", "dose", "increase", ",", "based", "on", "molecular", "response", ",", "in", "elderly", "CML", "patients", "treated", "with", "second-line", "bosutinib", "produced", "high", "response", "rates", ";", "few", "patients", "required", "a", "dose", "increase", "to", "400", "mg", ",", "while", "most", "pts", "remained", "on", "300", "mg", "or", "less", "." ] } ]
PMC11155445
Compound (161l) showed the highest larvicidal activity with LC50 values of 0.0044 mM and 0.0070 mM, and LC90 values of 0.0058 mM and 0.0103 mM against C. quinquefasciatus and A. aegypti, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "(", "161l", ")", "showed", "the", "highest", "larvicidal", "activity", "with", "LC50", "values", "of", "0.0044", "mM", "and", "0.0070", "mM", ",", "and", "LC90", "values", "of", "0.0058", "mM", "and", "0.0103", "mM", "against", "C.", "quinquefasciatus", "and", "A.", "aegypti", ",", "respectively", "." ] } ]
PMC10607604
Briefly, HA-tagged PTPN13 was cloned in the pcDNA5/FRT vector (Invitrogen) to generate the pcDNA5/FRT/PTPN13 plasmid.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "HA-tagged", "PTPN13", "was", "cloned", "in", "the", "pcDNA5/FRT", "vector", "(", "Invitrogen", ")", "to", "generate", "the", "pcDNA5/FRT/PTPN13", "plasmid", "." ] } ]
PMC7171147
COL11A1 also increased the levels of ATP and NADH, byproducts of FAO, in ES2 cells cultured on COL11A1 extract (Fig. 1E), which was attenuated by CPT1A knockdown using shRNAs (Fig. 1E, S1F-G) or treatment with a pharmacological inhibitor of CPT1A, etomoxir (Fig. S2A, B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COL11A1", "also", "increased", "the", "levels", "of", "ATP", "and", "NADH", ",", "byproducts", "of", "FAO", ",", "in", "ES2", "cells", "cultured", "on", "COL11A1", "extract", "(", "Fig.", "1E", ")", ",", "which", "was", "attenuated", "by", "CPT1A", "knockdown", "using", "shRNAs", "(", "Fig.", "1E", ",", "S1F-G", ")", "or", "treatment", "with", "a", "pharmacological", "inhibitor", "of", "CPT1A", ",", "etomoxir", "(", "Fig.", "S2A", ",", "B", ")", "." ] } ]
PMC11122631
Subfraction C5 (95.0 mg) was separated by a silica gel CC, eluted stepwise by hexanes/acetone (15/1 to 0/1) to give fractions C5A–C5E.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subfraction", "C5", "(", "95.0", "mg", ")", "was", "separated", "by", "a", "silica", "gel", "CC", ",", "eluted", "stepwise", "by", "hexanes/acetone", "(", "15/1", "to", "0/1", ")", "to", "give", "fractions", "C5A", "–", "C5E", "." ] } ]
PMC10094712
In the work, a recombinant hSELENOM, in which the TGA codon was replaced by TGT, in preparative amounts was obtained.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "work", ",", "a", "recombinant", "hSELENOM", ",", "in", "which", "the", "TGA", "codon", "was", "replaced", "by", "TGT", ",", "in", "preparative", "amounts", "was", "obtained", "." ] } ]
PMC11180402
In addition, aberrant expression of SNHG1 contributes to the proliferation, metastasis, migration and invasion of cancer cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "aberrant", "expression", "of", "SNHG1", "contributes", "to", "the", "proliferation", ",", "metastasis", ",", "migration", "and", "invasion", "of", "cancer", "cells", "." ] } ]
PMC7039683
Eluted DNA was subjected to PCR amplification and library indexing, using the NEBNext High-Fidelity 2x PCR Master Mix (New England Biolabs, Ipswich, MA) with a customized Nextera PCR primer pair, according to the following program: 72°C for 5 min; 98°C for 30 s; 11 cycles of 98°C for 10 s, 63°C for 30 s, and 72°C for 1 min; and hold at 4°C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eluted", "DNA", "was", "subjected", "to", "PCR", "amplification", "and", "library", "indexing", ",", "using", "the", "NEBNext", "High-Fidelity", "2x", "PCR", "Master", "Mix", "(", "New", "England", "Biolabs", ",", "Ipswich", ",", "MA", ")", "with", "a", "customized", "Nextera", "PCR", "primer", "pair", ",", "according", "to", "the", "following", "program", ":", "72", "°", "C", "for", "5", "min", ";", "98", "°", "C", "for", "30", "s", ";", "11", "cycles", "of", "98", "°", "C", "for", "10", "s", ",", "63", "°", "C", "for", "30", "s", ",", "and", "72", "°", "C", "for", "1", "min", ";", "and", "hold", "at", "4", "°", "C", "." ] } ]
PMC11703896
Detachment of cancer cell lines from the culture plates were also observed after treatment with rapamycin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detachment", "of", "cancer", "cell", "lines", "from", "the", "culture", "plates", "were", "also", "observed", "after", "treatment", "with", "rapamycin", "." ] } ]
PMC11794847
Using the TIDE algorithm, our results showcased a link between HVEM levels and immune dysfunction in NSCLC patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "TIDE", "algorithm", ",", "our", "results", "showcased", "a", "link", "between", "HVEM", "levels", "and", "immune", "dysfunction", "in", "NSCLC", "patients", "." ] } ]
PMC11635087
Electron microscopy image of the same area examined using a fluorescence microscope.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electron", "microscopy", "image", "of", "the", "same", "area", "examined", "using", "a", "fluorescence", "microscope", "." ] } ]
PMC10899471
G, H) Immunohistochemical analyses of the expressions levels of BATF2 and Ki67 in tumor xenografts.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", ",", "H", ")", "Immunohistochemical", "analyses", "of", "the", "expressions", "levels", "of", "BATF2", "and", "Ki67", "in", "tumor", "xenografts", "." ] } ]
PMC8592717
PCA had antiapoptotic and antiinflammatory effects and induced antioxidative stress in animal models with intracerebral hemorrhage (ICH) or cerebral ischemia.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "had", "antiapoptotic", "and", "antiinflammatory", "effects", "and", "induced", "antioxidative", "stress", "in", "animal", "models", "with", "intracerebral", "hemorrhage", "(", "ICH", ")", "or", "cerebral", "ischemia", "." ] } ]
PMC9712534
Substitutions of T48I and Y49F in TOP2A of CHO cells were previously reported to confer ICRF resistance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Substitutions", "of", "T48I", "and", "Y49F", "in", "TOP2A", "of", "CHO", "cells", "were", "previously", "reported", "to", "confer", "ICRF", "resistance", "." ] } ]
PMC11411004
Cells in the exponential growth phase were inoculated at a concentration of 300,000 cells per milliliter into 125-mL Erlenmeyer flasks, each containing 30 mL of culture medium.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "in", "the", "exponential", "growth", "phase", "were", "inoculated", "at", "a", "concentration", "of", "300,000", "cells", "per", "milliliter", "into", "125-mL", "Erlenmeyer", "flasks", ",", "each", "containing", "30", "mL", "of", "culture", "medium", "." ] } ]
PMC11281366
To assess whether the upregulation of CD59 mRNA was linked to the downregulation of specific miRNAs, we first identified the miRNAs that were the most downregulated in GFP-positive cells (Figure 2C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "whether", "the", "upregulation", "of", "CD59", "mRNA", "was", "linked", "to", "the", "downregulation", "of", "specific", "miRNAs", ",", "we", "first", "identified", "the", "miRNAs", "that", "were", "the", "most", "downregulated", "in", "GFP-positive", "cells", "(", "Figure", "2C", ")", "." ] } ]
PMC11658074
Created with BioRender.com) Photodamage is the most common and primary extrinsic cause of skin ageing .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Created", "with", "BioRender.com", ")", "Photodamage", "is", "the", "most", "common", "and", "primary", "extrinsic", "cause", "of", "skin", "ageing", "." ] } ]
PMC11762280
Western blotting assay was performed as previously described .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blotting", "assay", "was", "performed", "as", "previously", "described", "." ] } ]
PMC11706491
Once cells pass this point, they are committed to complete the next cell cycle.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "cells", "pass", "this", "point", ",", "they", "are", "committed", "to", "complete", "the", "next", "cell", "cycle", "." ] } ]
PMC11366496
Transwell migration and invasion assays in various treatment cohorts and histogram quantification (panels). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transwell", "migration", "and", "invasion", "assays", "in", "various", "treatment", "cohorts", "and", "histogram", "quantification", "(", "panels", ")", ".", "(" ] } ]
PMC11075223
At present, Cimicifugae Rhizoma is mainly applied clinically in the form of prescription; therefore, it is necessary to speed up the mechanism of action, toxicity and side effects of Cimicifugae Rhizoma compatibility in order to play a safer and more effective role in clinical application.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "present", ",", "Cimicifugae", "Rhizoma", "is", "mainly", "applied", "clinically", "in", "the", "form", "of", "prescription", ";", "therefore", ",", "it", "is", "necessary", "to", "speed", "up", "the", "mechanism", "of", "action", ",", "toxicity", "and", "side", "effects", "of", "Cimicifugae", "Rhizoma", "compatibility", "in", "order", "to", "play", "a", "safer", "and", "more", "effective", "role", "in", "clinical", "application", "." ] } ]
PMC11507371
Thus, a progressive overload of the cellular antioxidative system seems plausible as a consequence of CAP treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "a", "progressive", "overload", "of", "the", "cellular", "antioxidative", "system", "seems", "plausible", "as", "a", "consequence", "of", "CAP", "treatment", "." ] } ]
PMC8557138
These models when treated with different anti-cancer drugs including sorafenib showed a marked reduction in tumor growth, and angiogenesis (Sobrino et al. 2016).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "models", "when", "treated", "with", "different", "anti-cancer", "drugs", "including", "sorafenib", "showed", "a", "marked", "reduction", "in", "tumor", "growth", ",", "and", "angiogenesis", "(", "Sobrino", "et", "al.", "2016", ")", "." ] } ]
PMC10253553
Consequently, approximately 20% of patients will be diagnosed with late-stage metastatic ccRCC .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "approximately", "20", "%", "of", "patients", "will", "be", "diagnosed", "with", "late-stage", "metastatic", "ccRCC", "." ] } ]
PMC11525028
Body weight of the PDX model treated with paliperidone, AG-401, or combination (n = 5 per group). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Body", "weight", "of", "the", "PDX", "model", "treated", "with", "paliperidone", ",", "AG-401", ",", "or", "combination", "(", "n", "=", "5", "per", "group", ")", ".", "(" ] } ]
PMC10040136
The proportion of MSC measured by the FACS method and the immunofluorescence method in 12 pairs of paired samples showed consistent trends (F, G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proportion", "of", "MSC", "measured", "by", "the", "FACS", "method", "and", "the", "immunofluorescence", "method", "in", "12", "pairs", "of", "paired", "samples", "showed", "consistent", "trends", "(", "F", ",", "G", ")", "." ] } ]
PMC11576293
The EGFR-TK assay (Al-Wahaibi et al., 2022; Alshammari et al., 2022) was used to assess the inhibitory activity of the most potent antiproliferative compounds 14, 17, 19, 22, 25, and 29, against EGFR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EGFR-TK", "assay", "(", "Al-Wahaibi", "et", "al.", ",", "2022", ";", "Alshammari", "et", "al.", ",", "2022", ")", "was", "used", "to", "assess", "the", "inhibitory", "activity", "of", "the", "most", "potent", "antiproliferative", "compounds", "14", ",", "17", ",", "19", ",", "22", ",", "25", ",", "and", "29", ",", "against", "EGFR", "." ] } ]
PMC10812665
This unique overall pattern led to the accumulation of metabolites known as biomarkers of neurodegeneration (saccharopine, aminoadipate and branched-chain ketoacids).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "unique", "overall", "pattern", "led", "to", "the", "accumulation", "of", "metabolites", "known", "as", "biomarkers", "of", "neurodegeneration", "(", "saccharopine", ",", "aminoadipate", "and", "branched-chain", "ketoacids", ")", "." ] } ]
PMC11791264
C, stably expressed control vector (pCDH) or pCDH-SETD7 SKOV3 cells were generated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "C", ",", "stably", "expressed", "control", "vector", "(", "pCDH", ")", "or", "pCDH-SETD7", "SKOV3", "cells", "were", "generated", "." ] } ]
PMC11739484
Our findings highlight the diagnostic, prognostic, and therapeutic potential of MMP7, MMP11, and MMP14 in SKCM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "highlight", "the", "diagnostic", ",", "prognostic", ",", "and", "therapeutic", "potential", "of", "MMP7", ",", "MMP11", ",", "and", "MMP14", "in", "SKCM", "." ] } ]
PMC11628309
When selecting the most appropriate catecholaminergic cell line, it is important to consider the following key characteristics of dopaminergic neurons: the capacity to synthesize dopamine, expression of VMAT-2, formation of neuromelanin, and presence of the dopamine transporter (DAT) and monoamine oxidase (MAO).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "selecting", "the", "most", "appropriate", "catecholaminergic", "cell", "line", ",", "it", "is", "important", "to", "consider", "the", "following", "key", "characteristics", "of", "dopaminergic", "neurons", ":", "the", "capacity", "to", "synthesize", "dopamine", ",", "expression", "of", "VMAT-2", ",", "formation", "of", "neuromelanin", ",", "and", "presence", "of", "the", "dopamine", "transporter", "(", "DAT", ")", "and", "monoamine", "oxidase", "(", "MAO", ")", "." ] } ]
PMC5443223
In the present study, the association of CEP164 knockdown with radiosensitivity in the cells was investigated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "study", ",", "the", "association", "of", "CEP164", "knockdown", "with", "radiosensitivity", "in", "the", "cells", "was", "investigated", "." ] } ]
PMC10877303
Overall, the RMSD of the complexes remained below 2.5 Å, defining the stable nature of the complexes .Fig.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "the", "RMSD", "of", "the", "complexes", "remained", "below", "2.5", "Å", ",", "defining", "the", "stable", "nature", "of", "the", "complexes", ".Fig", "." ] } ]
PMC11285179
5Both CCL28 and retinoic acid could promote vascular normalization in vivo Both CCL28 and retinoic acid could promote vascular normalization in vivo To more clearly explore the function of CCL28 on stromal cells and immune cells in the tumor microenvironment, we performed single-cell sequencing analysis on tumor tissues of LLC-NC and LLC-CCL28.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "5Both", "CCL28", "and", "retinoic", "acid", "could", "promote", "vascular", "normalization", "in", "vivo", "Both", "CCL28", "and", "retinoic", "acid", "could", "promote", "vascular", "normalization", "in", "vivo", "To", "more", "clearly", "explore", "the", "function", "of", "CCL28", "on", "stromal", "cells", "and", "immune", "cells", "in", "the", "tumor", "microenvironment", ",", "we", "performed", "single-cell", "sequencing", "analysis", "on", "tumor", "tissues", "of", "LLC-NC", "and", "LLC-CCL28", "." ] } ]
PMC11655536
New targets and targeted therapy may help to achieve better outcomes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "New", "targets", "and", "targeted", "therapy", "may", "help", "to", "achieve", "better", "outcomes", "." ] } ]
PMC11783017
K7M2 cells were harvested and suspended in PBS at 4 °C.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K7M2", "cells", "were", "harvested", "and", "suspended", "in", "PBS", "at", "4", "°", "C", "." ] } ]
PMC11786704
Quantitative analysis of area coverage by Masson's trichrome staining. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "analysis", "of", "area", "coverage", "by", "Masson", "'s", "trichrome", "staining", ".", "(" ] } ]
PMC9429973
Several immune modulation/immune suppressive genes were significantly upregulated, in particular IL-10 and TGFb1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "immune", "modulation/immune", "suppressive", "genes", "were", "significantly", "upregulated", ",", "in", "particular", "IL-10", "and", "TGFb1", "." ] } ]
PMC10048572
Ding et al. in 8 AML patients confirmed hundreds of somatic mutations in tumor cells obtained in relapse compared to primary tumor cells using deep sequencing to determine the mutation spectrum.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ding", "et", "al.", "in", "8", "AML", "patients", "confirmed", "hundreds", "of", "somatic", "mutations", "in", "tumor", "cells", "obtained", "in", "relapse", "compared", "to", "primary", "tumor", "cells", "using", "deep", "sequencing", "to", "determine", "the", "mutation", "spectrum", "." ] } ]
PMC11700165
ITK-SYK and TEL-SYK (also known as ETV6-SYK) are human tumor-causing chimeric proteins containing the kinase region of SYK, and the membrane-targeting, N-terminal, PH-TH domain-doublet of ITK or the dimerizing SAM-PNT domain of TEL, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ITK-SYK", "and", "TEL-SYK", "(", "also", "known", "as", "ETV6-SYK", ")", "are", "human", "tumor-causing", "chimeric", "proteins", "containing", "the", "kinase", "region", "of", "SYK", ",", "and", "the", "membrane-targeting", ",", "N-terminal", ",", "PH-TH", "domain-doublet", "of", "ITK", "or", "the", "dimerizing", "SAM-PNT", "domain", "of", "TEL", ",", "respectively", "." ] } ]
PMC10809689
The grouping of blots cropped from different parts of different gels The results of western blot analysis showed that the expression of mTORC and GLS proteins in the THP-1 cell line had a spike at 24 h after Gal-9 treatment (p = 0.0001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "grouping", "of", "blots", "cropped", "from", "different", "parts", "of", "different", "gels", "The", "results", "of", "western", "blot", "analysis", "showed", "that", "the", "expression", "of", "mTORC", "and", "GLS", "proteins", "in", "the", "THP-1", "cell", "line", "had", "a", "spike", "at", "24", "h", "after", "Gal-9", "treatment", "(", "p", "=", "0.0001", ")", "." ] } ]
PMC11420784
Here, we demonstrate that UPEC utilizes PldA to evade this powerful exocytosis mechanism by blocking autophagosome formation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "demonstrate", "that", "UPEC", "utilizes", "PldA", "to", "evade", "this", "powerful", "exocytosis", "mechanism", "by", "blocking", "autophagosome", "formation", "." ] } ]
PMC11770130
g Food intake of mice treated by NTS in iWATs with Gfral knockdown (n = 5). *
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Food", "intake", "of", "mice", "treated", "by", "NTS", "in", "iWATs", "with", "Gfral", "knockdown", "(", "n", "=", "5", ")", ".", "*" ] } ]
PMC9429973
Lactate dehydrogenase, haemoglobin levels and reticulocyte count were also recorded.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactate", "dehydrogenase", ",", "haemoglobin", "levels", "and", "reticulocyte", "count", "were", "also", "recorded", "." ] } ]
PMC11409031
Identified eight gene modules and showcased the principal genes via the hdWGCNA pipeline. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identified", "eight", "gene", "modules", "and", "showcased", "the", "principal", "genes", "via", "the", "hdWGCNA", "pipeline", ".", "(" ] } ]
PMC11228511
Similar analyses were performed for NM ruptures.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "analyses", "were", "performed", "for", "NM", "ruptures", "." ] } ]
PMC9429973
PFS was the primary endpoint.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "PFS", "was", "the", "primary", "endpoint", "." ] } ]
PMC11746948
Our findings indicated that inhibiting GPX4 palmitoylation amplified the effects of RSL3 to trigger ferroptosis and markedly suppressed the growth of xenografted tumors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "indicated", "that", "inhibiting", "GPX4", "palmitoylation", "amplified", "the", "effects", "of", "RSL3", "to", "trigger", "ferroptosis", "and", "markedly", "suppressed", "the", "growth", "of", "xenografted", "tumors", "." ] } ]
PMC6222726
yatein (17) and bursehernin (18).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "yatein", "(", "17", ")", "and", "bursehernin", "(", "18", ")", "." ] } ]
PMC11128598
Cell viability was calculated by MTT assays after treatment with the indicated doses of CQ for 24, 48 and 72 h. The half maximal inhibitory concentration (IC50) was calculated at 72 h post-treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "was", "calculated", "by", "MTT", "assays", "after", "treatment", "with", "the", "indicated", "doses", "of", "CQ", "for", "24", ",", "48", "and", "72", "h.", "The", "half", "maximal", "inhibitory", "concentration", "(", "IC50", ")", "was", "calculated", "at", "72", "h", "post-treatment", "." ] } ]
PMC11422497
Establishment of xenograft tumor model in nude mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Establishment", "of", "xenograft", "tumor", "model", "in", "nude", "mice", "." ] } ]
PMC11766309
We demonstrated that YKT6 was highly expressed in advanced CESCs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "demonstrated", "that", "YKT6", "was", "highly", "expressed", "in", "advanced", "CESCs", "." ] } ]
PMC11686380
Neuron cells were then cultured in Neurobasal medium with B27 supplement (Thermo Scientific, Waltham, MA), 1 mM L-glutamine, 100 U/ml penicillin, and 100 µg/ml streptomycin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neuron", "cells", "were", "then", "cultured", "in", "Neurobasal", "medium", "with", "B27", "supplement", "(", "Thermo", "Scientific", ",", "Waltham", ",", "MA", ")", ",", "1", "mM", "L-glutamine", ",", "100", "U/ml", "penicillin", ",", "and", "100", "µg/ml", "streptomycin", "." ] } ]
PMC11188874
The cytosolic enzyme lactate dehydrogenase (LDH) is released into culture medium upon plasma membrane damage and cell death.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cytosolic", "enzyme", "lactate", "dehydrogenase", "(", "LDH", ")", "is", "released", "into", "culture", "medium", "upon", "plasma", "membrane", "damage", "and", "cell", "death", "." ] } ]
PMC11701801
Furthermore, we proposed the following molecular mechanism underlying synthetic lethality induced by simultaneous inhibition of CBP/p300 in SMARCB1-deficient cancers: in SMARCB1-proficient cells, the SWI/SNF complex containing SMARCB1 represses transcription of KREMEN2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "proposed", "the", "following", "molecular", "mechanism", "underlying", "synthetic", "lethality", "induced", "by", "simultaneous", "inhibition", "of", "CBP/p300", "in", "SMARCB1-deficient", "cancers", ":", "in", "SMARCB1-proficient", "cells", ",", "the", "SWI/SNF", "complex", "containing", "SMARCB1", "represses", "transcription", "of", "KREMEN2", "." ] } ]
PMC3765139
Virtually 83% of Na8 cells bound anti-CD271 antibody as opposed to 2% of HBL cells.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Virtually", "83", "%", "of", "Na8", "cells", "bound", "anti-CD271", "antibody", "as", "opposed", "to", "2", "%", "of", "HBL", "cells", "." ] } ]
PMC11129910
Paraffin-embedded tissue sections were sent to Neogenomics (Fort Myers, FL) to detect H-RAS and K-RAS mutations in three of our 100% spindle cell carcinoma cases.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paraffin-embedded", "tissue", "sections", "were", "sent", "to", "Neogenomics", "(", "Fort", "Myers", ",", "FL", ")", "to", "detect", "H-RAS", "and", "K-RAS", "mutations", "in", "three", "of", "our", "100", "%", "spindle", "cell", "carcinoma", "cases", "." ] } ]
PMC10093184
RT-qPCR primer details are listed in Supplementary Table S1 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-qPCR", "primer", "details", "are", "listed", "in", "Supplementary", "Table", "S1", "." ] } ]
PMC11627060
Mechanistic clarity is essential since different apoptotic pathways can have varied therapeutic implications.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanistic", "clarity", "is", "essential", "since", "different", "apoptotic", "pathways", "can", "have", "varied", "therapeutic", "implications", "." ] } ]
PMC11696576
PBMCs were isolated from buffy coats using Lymphoprep as described by the manufacturer (STEMCELL Technologies, Vancouver, Canada).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PBMCs", "were", "isolated", "from", "buffy", "coats", "using", "Lymphoprep", "as", "described", "by", "the", "manufacturer", "(", "STEMCELL", "Technologies", ",", "Vancouver", ",", "Canada", ")", "." ] } ]
PMC3675084
Human ovarian cancer cell lines SKOV-3 and OVCAR-3 were obtained from American Type Culture Collection (ATCC, Manassas, VA).
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "ovarian", "cancer", "cell", "lines", "SKOV-3", "and", "OVCAR-3", "were", "obtained", "from", "American", "Type", "Culture", "Collection", "(", "ATCC", ",", "Manassas", ",", "VA", ")", "." ] } ]
PMC5311252
All analyses were performed in R (version 3.2.2) using the t.test and p.adjust functions from the R stats package.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "analyses", "were", "performed", "in", "R", "(", "version", "3.2.2", ")", "using", "the", "t.test", "and", "p.adjust", "functions", "from", "the", "R", "stats", "package", "." ] } ]
PMC8427838
Cells were fixed and pictures were taken under Nikon Deconvolution microscope equipped with camera.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "fixed", "and", "pictures", "were", "taken", "under", "Nikon", "Deconvolution", "microscope", "equipped", "with", "camera", "." ] } ]
PMC8998437
The CCR5 transcripts were either not found (i.e., in the EBV-negative and latency I BL cell lines) or were hardly detectable in LCLs as in the type III and type II BL cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CCR5", "transcripts", "were", "either", "not", "found", "(", "i.e.", ",", "in", "the", "EBV-negative", "and", "latency", "I", "BL", "cell", "lines", ")", "or", "were", "hardly", "detectable", "in", "LCLs", "as", "in", "the", "type", "III", "and", "type", "II", "BL", "cell", "lines", "." ] } ]
PMC11790599
Mean fluorescence intensity of the population was determined.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "fluorescence", "intensity", "of", "the", "population", "was", "determined", "." ] } ]
PMC11750165
Genomic editing identified in Cas9/sgRNA-injected embryos by T7E1 endonuclease at 24-hpf (B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genomic", "editing", "identified", "in", "Cas9/sgRNA-injected", "embryos", "by", "T7E1", "endonuclease", "at", "24-hpf", "(", "B", ")", "." ] } ]
PMC11756907
Nevertheless, both forms of complex are valuable from a clinical point of view – the possibility of regulating the duration of the drug’s action and obtaining, if necessary, the pharmacological effect of prolonged release of the active substance (the so-called depot form).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "both", "forms", "of", "complex", "are", "valuable", "from", "a", "clinical", "point", "of", "view", "–", "the", "possibility", "of", "regulating", "the", "duration", "of", "the", "drug", "’s", "action", "and", "obtaining", ",", "if", "necessary", ",", "the", "pharmacological", "effect", "of", "prolonged", "release", "of", "the", "active", "substance", "(", "the", "so-called", "depot", "form", ")", "." ] } ]
PMC11228511
High-resolution confocal microscopy of cultured SMCs revealed that lamin A and lamin B1 form similar but distinct meshworks—consistent with earlier studies (11, 12).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High-resolution", "confocal", "microscopy", "of", "cultured", "SMCs", "revealed", "that", "lamin", "A", "and", "lamin", "B1", "form", "similar", "but", "distinct", "meshworks", "—", "consistent", "with", "earlier", "studies", "(", "11", ",", "12", ")", "." ] } ]
PMC11506827
Notably, the early apoptotic 786-O cell population was larger than the early apoptotic A498 cell population (Figure 3A), indicating a delayed apoptotic signaling response, possibly due to higher TRAIL resistance in 786-O cells.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Notably", ",", "the", "early", "apoptotic", "786-O", "cell", "population", "was", "larger", "than", "the", "early", "apoptotic", "A498", "cell", "population", "(", "Figure", "3A", ")", ",", "indicating", "a", "delayed", "apoptotic", "signaling", "response", ",", "possibly", "due", "to", "higher", "TRAIL", "resistance", "in", "786-O", "cells", "." ] } ]
PMC9429973
Two third of patients (66%) needed phlebotomies and 2 patients antiplatelet agents: 6 (85.7%) patients with Tibetan mutation and 4 (80%) of the others with different mutations needed treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "third", "of", "patients", "(", "66", "%", ")", "needed", "phlebotomies", "and", "2", "patients", "antiplatelet", "agents", ":", "6", "(", "85.7", "%", ")", "patients", "with", "Tibetan", "mutation", "and", "4", "(", "80", "%", ")", "of", "the", "others", "with", "different", "mutations", "needed", "treatment", "." ] } ]
PMC9429973
All patients had received chemotherapy (pediatric-like in half of the patients), while 9 patients received also allo-HSCT.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "had", "received", "chemotherapy", "(", "pediatric-like", "in", "half", "of", "the", "patients", ")", ",", "while", "9", "patients", "received", "also", "allo-HSCT", "." ] } ]
PMC9429973
Seventy-six patients (76.8%) had RS treated with intensive chemotherapy protocols, mainly R-CHOP-like regimens for the first line treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventy-six", "patients", "(", "76.8", "%", ")", "had", "RS", "treated", "with", "intensive", "chemotherapy", "protocols", ",", "mainly", "R-CHOP-like", "regimens", "for", "the", "first", "line", "treatment", "." ] } ]
PMC11413393
A relative black box in our mechanistic exploration of PRMT1 in ccRCC revolves around the influence of its histone substrate, H4R3me2a on the overall cellular transcriptome and resulting proteome.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "relative", "black", "box", "in", "our", "mechanistic", "exploration", "of", "PRMT1", "in", "ccRCC", "revolves", "around", "the", "influence", "of", "its", "histone", "substrate", ",", "H4R3me2a", "on", "the", "overall", "cellular", "transcriptome", "and", "resulting", "proteome", "." ] } ]
PMC11803149
Graphs show mean fluorescence intensity (MFI) and percentages of cells positive for each protein. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphs", "show", "mean", "fluorescence", "intensity", "(", "MFI", ")", "and", "percentages", "of", "cells", "positive", "for", "each", "protein", ".", "(" ] } ]
PMC11612508
The sage leaves were thoroughly cleaned using tap water to remove surface dirt, followed by ultrapure water.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sage", "leaves", "were", "thoroughly", "cleaned", "using", "tap", "water", "to", "remove", "surface", "dirt", ",", "followed", "by", "ultrapure", "water", "." ] } ]
PMC11064533
NA category corresponds to genes that were not assigned to any of the COGs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NA", "category", "corresponds", "to", "genes", "that", "were", "not", "assigned", "to", "any", "of", "the", "COGs", "." ] } ]
PMC6934009
Furthermore, an overgeneration of ROS in the cancer cells has been found to be linked with autophagy (19,20).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "an", "overgeneration", "of", "ROS", "in", "the", "cancer", "cells", "has", "been", "found", "to", "be", "linked", "with", "autophagy", "(", "19,20", ")", "." ] } ]
PMC6835428
Moreover, it can be also used as a linker for specific ligands on the surface of delivery particles .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "it", "can", "be", "also", "used", "as", "a", "linker", "for", "specific", "ligands", "on", "the", "surface", "of", "delivery", "particles", "." ] } ]
PMC11763111
J Percentage of phosphor-NF-kB p65 (Ser536) expression in CCRF-CEM pre-incubated CAR-T with 5, 10, 20 µmol JSH-23 (n = 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J", "Percentage", "of", "phosphor-NF-kB", "p65", "(", "Ser536", ")", "expression", "in", "CCRF-CEM", "pre-incubated", "CAR-T", "with", "5", ",", "10", ",", "20", "µmol", "JSH-23", "(", "n", "=", "3", ")", "." ] } ]
PMC11763126
Data are presented as mean ± standard deviation (SD) from three independent experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean", "±", "standard", "deviation", "(", "SD", ")", "from", "three", "independent", "experiments", "." ] } ]
PMC8041314
Clear positive hits” as indicators for triple ABCB1, ABCC1, and ABCG2 inhibition were defined as follows: (i) the respective substructure must have appeared at least five times within the 1049 molecules; (ii) group D must be at least 15%; and either (iii) group D must be at least equal to group B, or (iv) group E must be at least equal to group B. “Clear negative hits” were defined as follows: (i) the respective substructure must have appeared at least five times amongst the 1049 molecules; (ii) the respective substructure must not account for class 7 compounds (group D must be 0%); and (iii) group B must be at least equal to group C. Model validation for C@PA has been conducted by applying Screen 2 (“Positive Pattern”) and Screen 3 (“Negative Pattern”) using a query search tool implemented in InstantJChem.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clear", "positive", "hits", "”", "as", "indicators", "for", "triple", "ABCB1", ",", "ABCC1", ",", "and", "ABCG2", "inhibition", "were", "defined", "as", "follows", ":", "(", "i", ")", "the", "respective", "substructure", "must", "have", "appeared", "at", "least", "five", "times", "within", "the", "1049", "molecules", ";", "(", "ii", ")", "group", "D", "must", "be", "at", "least", "15", "%", ";", "and", "either", "(", "iii", ")", "group", "D", "must", "be", "at", "least", "equal", "to", "group", "B", ",", "or", "(", "iv", ")", "group", "E", "must", "be", "at", "least", "equal", "to", "group", "B.", "“", "Clear", "negative", "hits", "”", "were", "defined", "as", "follows", ":", "(", "i", ")", "the", "respective", "substructure", "must", "have", "appeared", "at", "least", "five", "times", "amongst", "the", "1049", "molecules", ";", "(", "ii", ")", "the", "respective", "substructure", "must", "not", "account", "for", "class", "7", "compounds", "(", "group", "D", "must", "be", "0", "%", ")", ";", "and", "(", "iii", ")", "group", "B", "must", "be", "at", "least", "equal", "to", "group", "C.", "Model", "validation", "for", "C@PA", "has", "been", "conducted", "by", "applying", "Screen", "2", "(", "“", "Positive", "Pattern", "”", ")", "and", "Screen", "3", "(", "“", "Negative", "Pattern", "”", ")", "using", "a", "query", "search", "tool", "implemented", "in", "InstantJChem", "." ] } ]
PMC11098378
The fusion protein was affinity-purified using TALON Metal Affinity Resin (Takara Biosciences; S4 Table) and eluted in buffer containing 25 mM HEPES, 100 mM NaCl, 100 mM KCl, 10% glycerol, 10 mM MgCl2, 0.5 mM EDTA, 1 mM DTT, and 500 mM Imidazole.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fusion", "protein", "was", "affinity-purified", "using", "TALON", "Metal", "Affinity", "Resin", "(", "Takara", "Biosciences", ";", "S4", "Table", ")", "and", "eluted", "in", "buffer", "containing", "25", "mM", "HEPES", ",", "100", "mM", "NaCl", ",", "100", "mM", "KCl", ",", "10", "%", "glycerol", ",", "10", "mM", "MgCl2", ",", "0.5", "mM", "EDTA", ",", "1", "mM", "DTT", ",", "and", "500", "mM", "Imidazole", "." ] } ]
PMC10988555
Besides these facts, the high SI and low IC50 for the A2780 cell line were the decisive factors for choosing this cell line for further biological studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", "these", "facts", ",", "the", "high", "SI", "and", "low", "IC50", "for", "the", "A2780", "cell", "line", "were", "the", "decisive", "factors", "for", "choosing", "this", "cell", "line", "for", "further", "biological", "studies", "." ] } ]
PMC10114490
Yellow dots represent genes encoding hepatocyte-relevant secreted glycoproteins such as decorin (DCN) or fibromodulin (FMOD).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yellow", "dots", "represent", "genes", "encoding", "hepatocyte-relevant", "secreted", "glycoproteins", "such", "as", "decorin", "(", "DCN", ")", "or", "fibromodulin", "(", "FMOD", ")", "." ] } ]
PMC11013014
The obtained residue was purified by silica gel column chromatography.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "residue", "was", "purified", "by", "silica", "gel", "column", "chromatography", "." ] } ]
PMC10213179
Efficiency of internalization shown is relative to the SCR sequence. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efficiency", "of", "internalization", "shown", "is", "relative", "to", "the", "SCR", "sequence", ".", "(" ] } ]
PMC9429973
We have estimated for the first time the frequency of clonal hematopoiesis in these patients and found that clonal CIN patients have significantly higher risk to develop MDS/AML compared to non-clonal CIN patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "estimated", "for", "the", "first", "time", "the", "frequency", "of", "clonal", "hematopoiesis", "in", "these", "patients", "and", "found", "that", "clonal", "CIN", "patients", "have", "significantly", "higher", "risk", "to", "develop", "MDS/AML", "compared", "to", "non-clonal", "CIN", "patients", "." ] } ]
PMC10957991
Together, these data indicate that TRPV4 is localized prominently in the stem/progenitor cells of the mammary basal layer and could be initial responder to mechanical changes in the microenvironment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", "data", "indicate", "that", "TRPV4", "is", "localized", "prominently", "in", "the", "stem/progenitor", "cells", "of", "the", "mammary", "basal", "layer", "and", "could", "be", "initial", "responder", "to", "mechanical", "changes", "in", "the", "microenvironment", "." ] } ]
PMC11394730
The activation of STAT3 and PI3K/Akt/mTOR is mediated by these two cytokines .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "activation", "of", "STAT3", "and", "PI3K/Akt/mTOR", "is", "mediated", "by", "these", "two", "cytokines", "." ] } ]
PMC11295144
The enlarged images are 10 × zoom in. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "enlarged", "images", "are", "10", "×", "zoom", "in", ".", "(" ] } ]
PMC11628309
An advantage of the BE (2)-M17 cell line is that its neuronal phenotype allows the study of the molecular machinery that synthesizes and subsequently release neurotransmitters.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "advantage", "of", "the", "BE", "(2)-M17", "cell", "line", "is", "that", "its", "neuronal", "phenotype", "allows", "the", "study", "of", "the", "molecular", "machinery", "that", "synthesizes", "and", "subsequently", "release", "neurotransmitters", "." ] } ]
PMC8662250
The suspension was rapidly passed through a syringe needle five to six times to facilitate cell lysis and centrifuged for 15 min at 13,000×g to obtain the cytoplasmic fraction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "suspension", "was", "rapidly", "passed", "through", "a", "syringe", "needle", "five", "to", "six", "times", "to", "facilitate", "cell", "lysis", "and", "centrifuged", "for", "15", "min", "at", "13,000", "×", "g", "to", "obtain", "the", "cytoplasmic", "fraction", "." ] } ]
PMC9429973
eMeds has a medication interaction warning function, but this has currently been disabled.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "eMeds", "has", "a", "medication", "interaction", "warning", "function", ",", "but", "this", "has", "currently", "been", "disabled", "." ] } ]
PMC6222635
After being cultured for 24 h, the cells were treated with DPFs in a concentration series for 24 h and 48 h. MTT was then added and incubated with the cells for 4 h. MTT was removed, and 100 μL of DMSO was added to each well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "being", "cultured", "for", "24", "h", ",", "the", "cells", "were", "treated", "with", "DPFs", "in", "a", "concentration", "series", "for", "24", "h", "and", "48", "h.", "MTT", "was", "then", "added", "and", "incubated", "with", "the", "cells", "for", "4", "h.", "MTT", "was", "removed", ",", "and", "100", "μL", "of", "DMSO", "was", "added", "to", "each", "well", "." ] } ]
PMC9429973
In the USA, VEN is approved in combination with an HMA or LDAC for Tx of pts with ND AML ≥ 75 years (y) of age or who cannot use IC due to comorbidities.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "USA", ",", "VEN", "is", "approved", "in", "combination", "with", "an", "HMA", "or", "LDAC", "for", "Tx", "of", "pts", "with", "ND", "AML", "≥", "75", "years", "(", "y", ")", "of", "age", "or", "who", "can", "not", "use", "IC", "due", "to", "comorbidities", "." ] } ]
PMC7504302
The epithelial–mesenchymal transition (EMT) is a vital cellular program wherein epithelial cells lose their polarized epithelial phenotype and acquire features inherent to mesenchymal-like cells, characterized by increased expression of extracellular matrix (ECM) proteins, enhanced motility, invasiveness, metastasis, and resistance to apoptosis .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "epithelial", "–", "mesenchymal", "transition", "(", "EMT", ")", "is", "a", "vital", "cellular", "program", "wherein", "epithelial", "cells", "lose", "their", "polarized", "epithelial", "phenotype", "and", "acquire", "features", "inherent", "to", "mesenchymal-like", "cells", ",", "characterized", "by", "increased", "expression", "of", "extracellular", "matrix", "(", "ECM", ")", "proteins", ",", "enhanced", "motility", ",", "invasiveness", ",", "metastasis", ",", "and", "resistance", "to", "apoptosis", "." ] } ]
PMC10956161
The TCGA database was used to assess the diagnostic potential of PRDX6 expression in lung adenocarcinoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TCGA", "database", "was", "used", "to", "assess", "the", "diagnostic", "potential", "of", "PRDX6", "expression", "in", "lung", "adenocarcinoma", "." ] } ]