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PMC9429973
Additionally, hnRNP K overexpressing cells showed NS hallmarks associated with an increase of the number of nucleoli, and total area of the nucleoli and nucleus (Figure 1F-G).
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PMC11190238
The cohesin complex consists of SMC1, SMC3, RAD21 and SA1 or SA2 proteins.
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PMC11098378
Although it is unknown if SHOC2 restricts S. flexneri infection, this bacterium lacks flagella.
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PMC9429973
Genomic imbalances, and in particular deletions, are the most frequent cytogenetic rearrangements in T-ALL.
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PMC11286266
As trafficking is closely linked to proteolytic processing, WT ATF6α does not accumulate in the Golgi of stressed cells (Shen et al., 2002).
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PMC9429973
Regulatory T cells (TRegs) and T helper 17 cells (Th17) are CD4 T cell functional subsets and their balance (TH17/TReg) is essential for maintaining immune haemostasis Aims: To study T cell subsets and cytokines plasma levels in low risk MDS patients and healthy controls.
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PMC11718031
However, it should be noted cysteine is known to degrade quickly, which may interfere with the quantification of this amino acid (Calvet and Ryder 2014).
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PMC9844987
Weighted average cross correlations were calculated either across all promoters (A-B) or separately for promoter groups split based on their minimum correlation between contained decomposed promoter pairs (high Pearson’s correlation >0.39: top panel, low Pearson’s correlation <= 0.39: bottom panel) (C-D). (
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PMC11659734
Scheme of the comet assay procedure. (
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PMC11585587
As one of the most studied regulatory cascades, the MAPK pathway regulates the direction of cell growth growth.
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PMC7039683
Figure 5—figure supplement 3.Motifs enriched in hOEAEs and shared among zGPAEs, mPEAEs and hOEAEs.(A) Motifs enriched in hOEAEs.
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PMC11577421
These findings underscore the importance of albumin-glycocalyx interactions in the rational design and optimization of albumin-based drug delivery systems.
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PMC11218145
This response is usually elicited by inducing cell differentiation, apoptosis, and growth arrest.
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PMC7723249
In addition, we found that cytokines/pro-inflammatory factors or other viral factors secreted from CCHFV infected moDC cells enhance the entry of CCHFV contrary to HAZV.
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PMC8973085
calcd for C24H19FN4O3S: C, 62.33; H, 4.14; N, 12.11.
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PMC11281366
The level of background virus capture was subtracted from each data point.
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PMC11634794
It is plausible that LAMP1 may be associated with tumor autophagy and VHL gene regulation; nevertheless, its specific mode of action in ccRCC remains elusive.
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PMC11640247
Besides the involvement of RAC1, RAC3, and CDC42 variants in multiple NDDs , the Simons Foundation Autism Research Initiative (SFARI) database has identified several GAPs, GEFs, and downstream effectors as candidate genes for autism spectrum disorders (ASDs) .
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PMC9368503
The development of matched PDX-derived cell lines is non-trivial due to the relatively high failure rate associated with establishing cell lines from tumour specimens and there are only a few reported studies demonstrating success using this approach, including in breast, colorectal, and pancreatic cancers .
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PMC11752740
In the cancer group treated with combination therapy for 48 h, Caspase3 gene expression increased approximately 2.4-fold compared to the control group.
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PMC11320834
Liposomes were extruded gradually using polycarbonate membranes with pore sizes of 200 nm (5 times) and 100 nm (6 times) at room temperature using an extruder device from Northern Lipids Inc. (Vancouver, BC, Canada).
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PMC11530949
XRD analysis confirmed the crystal structure of the NPs.
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PMC9856122
A newly established cell-culture model GX-P2V (pangolin coronavirus) such as SARS-CoV-2 model is being used to identify therapeutic drugs against COVID-19.
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PMC8358176
In the end, using a microplate reader, the intensity of the dissolved formazan crystals was measured at 540 nm ( 23 - 25 ).
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PMC9429973
For CD38 nanobody, no significant differences were observed for the MFI values of samples, independent of daratumumab incubation (p=0,139) (figure 1A).
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PMC11806182
Fig. 5Differential gene expression and co-expression analysis based on tissue miR-330 expression in UCEC tissues.
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PMC10669966
Of note, all WDLPS samples (n = 10) were excluded from the analyses, due to low RNA yield from sequencing.
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PMC11411004
Cells harvested on day 7 were included in the analysis.
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PMC7709199
This is illustrated by the case study on IL-12B, which requires an immature glycan for proper folding.
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PMC11371627
Blood group profile revealed blood group type A, Rhesus D positivity (CcD.Ee) and K-k+ (kk) type.
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PMC9429973
Moreover, we demonstrated that the concomitant inhibition of hepatic and erythroid Tfr2 in anemia of CKD would represent a therapeutic opportunity to simultaneously increase iron availability and erythroid responsiveness in a balanced manner.
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PMC5874706
At the end of the process, for each amphiphilic α-cyclodextrin used, a 20-mL stock solution of nanoparticles containing 600 μM THN7 was obtained and then stored before use.
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PMC9429973
For mouse model study, Vav1-Cre mice, Asxl1 and Jak2 knockin alleles were used to achieve hematopoietic cell-specific Jak2/Asxl1 (Asxl1-/-Jak2), Jak2 (Jak2), and Asxl1 (Asxl1-/-) mice.
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PMC9429973
At last assessment, 27 (30.0%), 46 (51.1%), and 17 (18.9%) of 90 pts had a T-score indicating normal BMD, osteopenia, and osteoporosis (Table).
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PMC9429973
In a cross trial comparison Obinutzumab showed highest proportion of patients with strong MRD response independent from initial CD20 expression, whereas strong response to Ofatumumab seems to correlate with higher CD20 expression levels.
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PMC11704135
The antitumor activity of some synthesized pyrimidine compounds (10 and 12) against the breast cancer cell line MCF-7 as compared to cisplatin standard antitumor as detected using MTT assay.
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PMC10490530
Animal care and euthanasia were performed per the guidelines and approval of the Institutional Animal Ethics Committee (IAEC) recommendations.
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PMC9429973
The kinetics and function of CAR-T cells was monitored by quantitative PCR and flow cytometry.
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PMC9429973
Median (range) age was 63 (44–82) years, 57% were male, and 95% had ≥4 prior MM regimens (median 6 prior MM regimens).
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PMC10850553
The expression of tissue-type Plasminogen Activator (tPA) and Plasminogen in intracranial aneurysm (IA) lesions.
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PMC11055323
ns, not significant.
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PMC11658074
We employed PBA analysis, which sorts EVs into subpopulations on the basis of their surface proteins .
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PMC11604768
DNA removal from RNA fractions was confirmed by RT-PCR using the SuperScript IV One-Step RT-PCR System (Invitrogen) with and without addition of SuperScript IV RT Mix, followed by agarose gel electrophoresis.
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PMC11732628
Jeon et al. showed that targeting CDCA8 inhibits hepatocellular carcinoma via the restoration of the ATF tumor suppressor (36).
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PMC9444294
Attempts to detect the protein used in vitro assays have faced challenges.
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PMC11578343
More fascinating, mz‐visco‐NPS could enable studies that explore the contributions of different intermediate filaments (IFs) to the viscoelastic properties of cells.
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PMC9577200
while the expression of caspase-9 was reduced (p < 0.05).
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PMC11674891
We validated CRABP2 and FNDC4 levels in A427 cells overexpressing GRPR.
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PMC8427838
Moesin was one of the distinct proteins identified in these GST-TMIGD1 pull-downs (Fig. 1B).
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PMC11755519
The level of DNA damage was then assessed by measuring histone H2AX phosphorylation.
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PMC11747467
We further analyzed basal and luminal types determined by other classification systems ( Supplementary Figure S9A ).
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PMC8316344
We speculate that TFRC is degraded via PSMB5 but not PSMB1 and PSMB2 following ubiquitination, because PSMB5 is stimulated once upon TRIB2 is upregulated ; however, the exact mechanism underlying how TFRC is degraded in the proteasome will be discussed in the future.
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PMC11806106
We further performed BRET-based assays to measure the G protein activation induced by MOR agonists.
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PMC10006224
These and additional antibodies used in this study are listed in Supplementary Table 7.
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PMC10854447
VEGFR-2, a VEGFR family member, is a major mediator in tumour angiogenesis and is essential for solid tumour formation.
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PMC5261804
Ten of the top 20 PPIs involved CTNNB1, while 8 of 20 involved AKT1.
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PMC5716223
b Trypan blue exclusion assay.
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PMC11185260
Representative photographs of senescence-associated β-galactosidase staining of BT-12 and A-204.
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PMC9370419
Sex hormones have been reported to be associated with HBV infection and the risk of HCC.
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PMC11502066
CB1R, a GPCR activated by cannabinoids, is mostly expressed in several brain regions but also in some peripheral areas such as gastrointestinal tract and smooth muscles, where it performs a number of activities .
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PMC11483468
The β-galactosidase staining result showed that more than half of the cells became senescent at the sixth week.
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PMC9275501
NS made from hydrophobic drugs have the advantages of increasing drug loading, improving solubility, improving bioavailability (Sahu et al., 2016), and reducing side effects (Wang et al., 2019d).
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PMC10440586
Pro.,
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PMC11489175
Targeting of USP8 reduces survival pathway activation in ovarian carcinoma preclinical models of cisplatin resistance 90, offering novel opportunities for drug development in this disease and in many neoplastic diseases with a key role for EGFR activation including for example lung cancer in which down-regulation of the HER family receptor phosphorylation was observed following molecular and pharmacological inhibition of USP8 91.
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PMC11301095
Neck stiffness was noted, and superficial lymph nodes were not palpably enlarged.
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PMC10812665
It was found that planar polychlorinated biphenyls (PCBs) impaired neural crest function by affecting cellular gap junctions.
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PMC10728535
However, in some tumors, this gene plays an oncogenic role and induces cell growth and proliferation.
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PMC11753435
All ipTM scores, targets, and peptide sequences are provided in data file S1.
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PMC9105697
Target regions were pulled down with streptavidin-coated magnetic beads.
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PMC11705067
The molecular docking results indicated that FDX1 and DLAT might be potential drug targets for mitotane, adicicol and dihydrolipoic acid against ccRCC by inducing cuproptosis.
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PMC11525293
We first investigated whether Thal or Len could modulate the expression of ACE2 receptor in association with ΔNp63α degradation in human cells, such as HaCaT keratinocytes, A431 epidermoid cells, and A549 lung carcinoma cells, which express both ΔNp63α and ACE2 proteins.
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PMC9429973
The study was approved by the local institutional review board and supported by Sanofi Genzyme.
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PMC11401350
As expected, these trials including only a few PTCL patients might not give a clear-cut outcome and conclusion in terms of therapeutic benefit for these cancer patients.
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PMC11180402
E–F) Invasion abilities of 5637 (vector) and 5637 (Myc-DNMT3b) cells with/without ISO evaluated by Transwell assay (E), with relative invasion plotted (F).
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PMC7185206
Advanced melanomas are commonly treated with a PD-1 inhibitor such as pembrolizumab for first-line therapy, although most tumors exhibit or acquire resistance to treatment.
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PMC9429973
Across the 2 groups there was no difference in RFS or OS between pts who attained early or late OPR.
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PMC6222726
revealed that the most common lignan types are dibenzyl butyrolactones (nine compounds), picro aryltetraline derivatives (three compounds), aryltetraline derivatives (nine compounds), 7′,8′-dehydro-aryltetraline derivatives (five compounds), and dibenzylbutane diols (eight compounds).
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PMC11487720
Confocal or immunofluorescence microscopy was then carried out.
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PMC11680982
This therapeutic approach is also used as an adjuvant therapy for early-stage HR/HER2 subtypes in high-risk populations.
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PMC11078693
Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Kylie Walters (kylie.walters@nih.gov).
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PMC9429973
Despite relative high treatment discontinuation rates, adequate RDI levels were achieved and TRM did not exceed that reported for attenuated regimens in previous prospective trials.
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PMC10713411
Additionally, with the increasing study of PCD, different types of PCD such as parthanatos , entotic cell death , netotic cell death , lysosome-dependent cell death , alkaliptosis , oxciptosis , anoikis , etc.,
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PMC11291490
To overcome the major problem of low immunogenicity of DNA vaccines, effective delivery of plasmids to preferred tissues or cells is a key area of research, including codelivery with nanoparticles and bacterial vectors.
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PMC11678368
The theoretical structural analysis of the investigated metal complexes of 4-chloro and 5-chloro derivatives of 7-azaindole-3-carbaldehyde (trans-[PdCl2(4ClL)2] and trans-[MCl2(5ClL)2], where M = Pd(II) or Pt(II)) provides important information about their relative stability.
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PMC11756514
The percentage of S. aureus-positive cells was determined by flow cytometry.
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PMC9429973
There is currently a growing tendency to treat as many patients as possible because of the favorable impact of treatment on survival.
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PMC7185206
In figures, p values are denoted <0.05 with *, <0.01 with **, and <0.001 with ***.
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PMC9429973
In this latter case, it may be the first or even the only symptom.
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PMC11190062
The main finding of this work is that TLR9 and TLR4 activation increases the expression of pro-survival genes, provides resistance to both reversible and irreversible proteasome inhibitors, and, at the same time, reduces the expression of BCMA, a broadly expressed surface protein and a target for bispecific antibody therapy and CAR T cells in MM.
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PMC11098378
Y2H screening was conducted by Hybrigenics Services (Boston, MA).
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PMC11469524
However, there is a substantial crosstalk between these different downstream signaling molecules not yet characterized in sufficient detail.
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PMC10589262
Tumor volume was measured using a digital Vernier caliper (Mitutoyo; Kanagawa, Japan) three times a week after implantation and was calculated as 1/2 × length × width .
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PMC11371747
SEM was within the size of the marker.
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PMC11757230
Histopathologic examination revealed that the tumors formed in the xenografts had a similar histology across all groups (Fig. 5f).
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PMC9429973
Therefore, these markers have the potential to be used to identify individuals at increased risk of developing a destructive syndrome, and in conjunction with other risk factors (IgM secretion of more than 10% of CD 138+ plasma cells on immunohistochemistry) and to identify patients at increased risk of progression during MM.
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PMC8357004
Overexpression of TSGs plays a significant role in the induction and development of many cancers comprising gastric cancer, ovarian cancer, and colorectal cancers.
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PMC6684588
n = 10–12). (
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PMC11129910
Our previous work demonstrated that Rab25 significantly suppressed the levels of VEGF-A, VEGFR-1 mRNA, and VEGFR-1 protein.
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PMC10936243
Figure 2.Percentage of basic resources available for post-OVH cats as reported by participants.
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PMC11627398
MTF1 can protect cells under high copper conditions through activating metallothioneins, while it also can obtain scarce copper from the surroundings upon copper starvation through upregulating Ctr1B (a copper importer) .
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