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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Aims: The aim of this study is to identify drugs that are able to upregulate CD20 in BCP-ALL, in order to improve the efficacy of anti-CD20 mAbs in preclinical models of the disease.
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PMC9220170
A-172 cells were loaded with the probe dissolved in Hanks balanced salt solution (HBSS) composed of (mM): 156 NaCl, 3 KCl, 2 MgSO4, 1.25 KH2PO4, 2 CaCl2, 10 glucose, and 10 HEPES, pH 7.4 at 37 °C for 40 min with subsequent 15 min washout.
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PMC11711347
Given that the raw materials used in the synthesis of the complex are considered safe for biological systems, it is anticipated that the Ni(II)cysteine-tyrosinedithiocarbamate complex will have minimal adverse effects on normal cells .
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PMC11001582
Knock-in constructs were obtained by inserting sequences from pMC-eGFP, pMC-(GR)400 and pMC-(PR)400 into targeting vectors within the BstXI and XcmI sites.
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PMC11225860
Fig. 4Alisertib treatment causes cell cycle disruption and endomitosis.
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PMC9429973
Four studies included patients with α-thal but did not report HRQoL results separately for this subgroup.
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PMC9429973
Methods: Here, we integrated the differential gene expression profile between SOX11+ and SOX11- MCL primary cases with stem cell-related genes, specific SOX11 ChIP-chip bound genes and epigenomic data of MCLs.
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PMC11409031
Consequently, additional confirmation is required for the clinical prognostic model developed in this research, particularly through larger sample size cohorts and additional clinical data.
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PMC11637716
A female child of non‐consanguineous parents was born preterm after 35 + 3/7 gestational weeks in an external hospital.
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PMC9429973
Aims: The purpose of this study is to describe the indications and the modalities of radiotherapy (RT) for patients with RR-HL in our center, as well as its therapeutic results.
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PMC3730428
Thus, by ubiquitinating RIPK1, cIAP1 and cIAP2 act as positive regulators of the generally antiapoptotic, pro-inflammatory canonical NF-κB signaling pathway and at the same time inhibit caspase 8 activation in response to ligation of TNFR1.
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PMC10454535
Of the treatment groups, PIN showed the greatest expression of these proteins while the PIN/BTZ combination showed the least expression.
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PMC11144382
One gene, cellular retinoic acid binding protein 2 (Crabp2), was upregulated at both the RNA (2.59 fold, Table S2) and protein (2.83 fold, Table S2) levels, while 4 genes, vascular cell adhesion molecule 1 (Vcam1), potassium channel tetramerization domain containing 12 (Kctd12), isopentenyl-diphosphate delta isomerase 1 (Idi1), and eukaryotic translation initiation factor 2 subunit 3 structural gene Y-linked (Eif2s3y), were downregulated at both the RNA (-2.23 fold, -3.53 fold, -5.90 fold, and -7305.15 fold, respectively, Table S2) and protein (-4.89 fold, -4.77 fold, -2.14 fold, and -5.28 fold, respectively, Table S2) levels.
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PMC9429973
In the course of our work, we propose to screen for cases of anemia in patients with deep vein thrombosis.
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PMC11740508
A–D p-H2A.X foci per nucleus in the M231 variants and in SUM149PT quantitated over 4 days.
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PMC6617630
Our study also demonstrated that CD47 is expressed on the DHL and THL cells and abrogated by JQ1 treatment.
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PMC11766174
Supernatant obtained from the cell culture was centrifuged at 10,000× g for 5 min at RT to remove insoluble material before measuring CA levels on the Quanterix analyzer (Quanterix, Bullerica, MA, USA).
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PMC11306331
For dark-incubated cells we observed a sharp threshold in cellular FUS expression above which nuclear condensates were observed and corresponded to high enrichment scores (maximum divided by mean nuclear pixel intensity) (Fig. 3A, purple dots).
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PMC7039683
Peaks were called using MACS2 (v2.1.1) (Zhang et al., 2008).
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PMC11401358
CD characterization of SF.
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PMC11627133
Evaluating the fluorescence turn‐on and affinity of AP3‐SiRA connected via Loop1 (UGAA) or via Loop2 (UUCG) with the fluorogenic silicon rhodamine (SiR) dye revealed that only fusion into Loop2 retained SiRA's binding and turn‐on (Figure S6A, C, I).
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PMC8956657
The equivalent sequence in MERS-CoV ORF4b, RKRSHSP, lacks two Arg residues.
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PMC6889484
Severely delayed kinetics were observed in the 20% CEMSS:80% CEMSS/D128K clone mix 28 days post-infection (bottom). (
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PMC3765139
Bonnet and colleagues were the first who could phenotypically distinguish cells of acute myeloid leukemia (AML) with high tumorigenicity from the remaining tumor cells using surface markers.
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PMC11519567
We used PRT4165 (TargetMol T3110) to block the H2AK119ub modification.
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PMC9872547
DMEM growth medium containing 10% (v: v) fetal bovine serum (FBS) and 1% (v: v) of penicillin and streptomycin (all from GibcoBioCult, Paisley, Scotland, UK) was used for the culture of HeLa and fibroblast cells.
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PMC7823217
Fig. 5Bioprinted ovarian cancer model: A. The major subtype of ovarian neoplasm histologically divided in two subclassifications: Type I ovarian cancer contains low-grade, slow developing neoplastic cells that genuinely comes from boarder line tumors, which itself arises from ovarian surface epithelium, cysts, or endometriosis.
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PMC11286266
Transfected cells were selected in the presence of puromycin (8 μg/ml) and analysed under basal conditions at 7-, 19-, or 22-day post-transfection.
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PMC11632064
This suggests that the anti-inflammatory effects of BI-D1870 in A-375 cells (Fig 1D) are linked to RSK inhibition, as observed with selective RSK inhibitors such as LJH685 and LJI308 (Fig 1D and H).
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PMC9261184
BOG consumption in this study was 88 kg/km (47.5 kg/Nm) and diesel consumption was 1.3 kg/km (0.7 kg/Nm), allowing for all uses of gas and diesel.
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PMC11406030
A negative peptide was also chosen from the peptide microarray and ordered with a sequence of rGQSHAPNVNPrDaG. All the peptides were of >95% purity and underwent quality control at Watson Bio.
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PMC11506670
Cell counts were conducted over three consecutive days.
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PMC11747467
After exposure to RC48 (HT1376 and SW780), the proteins ERBB2, STAT3, and pSTAT3 (Tyr705) were detected by Western blot analysis. (
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PMC9429973
Median OS was 28 months (95% CI:18-38) for patients in the UHR group vs. 69 months (95% CI: 61-77) for others (p<0.001).
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PMC10033453
Oncolytic virotherapy has recently emerged as a promising approach and offers an opportunity for synergistic combinations with other established cancer therapies such as radiation and immune checkpoint inhibitors.
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PMC11802855
B, C Enrichment analysis of KEGG pathways for differentially expressed genes in the CXCL7-OE and NC RPMI8226 cell lines.
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PMC9429973
45% of patients had any grade AEs.
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PMC6160470
The exceptions to the “rule” are DACs with the shortest side chain (DAC-1 and −1Amide).
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PMC11727145
Notably, DED can be stored at 4 °C for up to five years (Figure 2D) without affecting recellularization, thus allowing for the preparation of large tissue lots that may be banked with uniformity.
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PMC6461034
ATCC: American Type Culture Collection The patient‐derived xenograft tumor tissue used in this study was derived from xenograft models that have been described before (Bertotti et al, 2015).
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PMC9096373
A study on the use of camptothecin derivative (TLC388) on H23 human non-small cell lung cancer cells revealed that the combination therapy of TLC388 and RT significantly increased γ-H2AX foci percentage (65.4% vs. 26.1%) compared with that using RT alone (22).
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PMC9429973
One year following Temferon, with no 2nd line therapy added, there was approximately 40% reduction in enhancing tumor volume compared to D+180.
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PMC9599726
We next investigated lipid peroxidation, the main hallmark of ferroptosis by flow cytometry using C11-BODIPY 581/591.
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PMC10900886
Whether EV-D68 utilizes one dissemination route or more to invade the CNS needs to be investigated further.
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PMC10631132
Gene expression of POU5F1 decreased in all groups significantly from the mesodermal to the hematopoietic stage (A).
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PMC11755519
In addition, the expression of p-AKT and p-STAT3 was higher in exosome-treated macrophages than in untreated macrophages.
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PMC6617630
Data represent mean ± SD from three independent experiments.
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PMC11295144
To test if NL2 can bind directly to the large intracellular domain of the γ2 subunit, GST-tagged ICL was expressed and purified from E. coli and incubated with the lysates of HEK293 cells transfected with HA-NL2.
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PMC5854676
In these samples, the scale bar was set to 100 nm, and a nanorod morphology of 12 nm diameter and about 80 nm length is shown in Fig. 3(a).
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PMC11607321
Future efforts should leverage multi-omic resources from cancer patients and derived models, such as organoids and patient derived xenografts (PDXs), to enhance training and explore transfer learning opportunities.
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PMC9429973
Summary/Conclusion: Our report suggests that CH may be seen as a biological link at the crossroads of IBDs and HMs, whose role is yet to be fully elucidated.
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PMC11787651
EpiConverter is available on GitHub at github.com/ChenfengZhao/EpiConverter.
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PMC10759659
In gastric cancer, ARID1A deficiency was correlated with dMMR and increased expression of PD-L1 .
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PMC11401350
The two lentiviral vector constructs incorporated into these LVs are presented.
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PMC7433824
Twenty mM P4 (Sigma‐P8783) was prepared as stock solutions dissolved in ethanol and sterile medium.
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PMC10291556
The scratched areas were shot immediately after the complex addition and then after 24 h with a Canon EOS 1200D camera attached to an Olympus CKX41 inverted microscope with a 10×/0.25 phase contrast objective.
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PMC11535726
In addition, most new species in China and Thailand were primarily found in tropical and subtropical regions, with nearly all species growing on decayed wood (Bao et al. 2018; Rodríguez-Andrade et al. 2020; Sun et al. 2021; Jayawardena et al. 2022; Senanayake et al. 2023; Liu et al. 2023b; Yang et al. 2023; de Farias et al. 2024; Louangphan et al. 2024).
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PMC11703992
Therefore, CD4+ T cells are not only one of the significant key cell clusters that trigger inflammatory responses, but also the important regulators of immune cell populations in GCA development.
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PMC11745823
A range of microRNAs has been reported to regulate HIF1.
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PMC11696576
CCRF-CEM cells seeded at 200,000 viable cells/mL were treated with AVX420 (0.5 μM) or DMSO (0.1%) and harvested after 1 hour, 6 h, or 16 h. Torin-1 (100 nM) treatment was harvested after 1 h. The flasks were placed on ice and the cell suspensions were transferred to 50 mL conical tubes for centrifugation (405 × g, 4 °C, 5 min).
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PMC11732523
Laboratory examination of the patient.
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PMC8345486
In A2780cis, as in A2780, the compound accumulation (1.49–8.21 nmol) was distinctly above the cisplatin amount (0.75 ± 0.044 nmol, data not shown).
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PMC11585994
This molecule can be taken up by cancer cells and subsequently release the small molecule nucleic acids within the acidic intracellular environment caused by heightened metabolic activity, making it a promising mediator for small molecule nucleic acid delivery.26–31 However, the delivery efficiency and inherent toxicity of PAMAM have limited its direct therapeutic application.
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PMC9429973
Than, we compared patients according to the conditioning regimen and the previous treatment.
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PMC11538390
A quantile-quantile plot is shown in the inset panel, where the observed ( y axis) negative log10 P values are plotted against the expected (x axis) negative log10 P values under null distribution (red line).
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PMC6461034
in a final round (e.g., round 4) completely distribute the contents of the “stock” vial, emptying it.
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PMC9024365
Graph depicts the mean cluster size of M1-3, S2, M4, CT chimera stratified for either co-localized or not co-localized with SD4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graph", "depicts", "the", "mean", "cluster", "size", "of", "M1", "-", "3", ",", "S2", ",", "M4", ",", "CT", "chimera", "stratified", "for", "either", "co-localized", "or", "not", "co-localized", "with", "SD4", "." ] } ]
PMC11676674
Regarding the assessment of C. monspeliensis genotoxic and antigenotoxic potential, in our work, a pipeline for automated micronuclei analysis using CellProfiler software (version number 4.2.6) with a fluorescence microscope, together with the application of new features and masks developed in the IDEAS software (version number 6.2) of the ImagestreamX imaging flow cytometer for scoring micronuclei in binucleated cells, was developed.
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PMC11713609
On the other hand, p53 inhibits VKORC1L1 to restrain the content of reduced vitamin K, a newly identified type of radical-trapping antioxidant, to promote ferroptosis (Yang et al., 2023).
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PMC11792888
p < 0.05 compared to control (the culture media in absence of scorpion venom) from Kruskal-Wallis non-parametric test.
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PMC11344246
RT-qPCR quantification of siRNA treatment showed equivalent relative knockdown (>80%), which may be why these cell lines showed similar growth inhibition by this method (Supplementary Figure S2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-qPCR", "quantification", "of", "siRNA", "treatment", "showed", "equivalent", "relative", "knockdown", "(", ">", "80", "%", ")", ",", "which", "may", "be", "why", "these", "cell", "lines", "showed", "similar", "growth", "inhibition", "by", "this", "method", "(", "Supplementary", "Figure", "S2", ")", "." ] } ]
PMC11704135
The desired compounds were created by treating 4,6-dimethylpyrimidine-2-thiol hydrochloride (1) with derivatives of benzoyl chloride and/or sulfonyl chloride, followed by oxidizing the products with glacial acetic acid and hydrogen peroxide.
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PMC10329237
After 0 and 48 hr, an inverted microscope was utilized to capture images from five independent, random microscopic fields (20).
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PMC9429973
POD24 was detected in 38 patients, and its impact on OS was not statistically significant (HR 8.1, p=0.070).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "POD24", "was", "detected", "in", "38", "patients", ",", "and", "its", "impact", "on", "OS", "was", "not", "statistically", "significant", "(", "HR", "8.1", ",", "p=0.070", ")", "." ] } ]
PMC9429973
Generic molecule would potentially reduces the cost with probable similar outcomes.
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PMC11539788
The precipitates were detected by western blotting. (
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PMC11753949
Moreover, 65% (± 15%) of them were at contacts between ER vesicles consistent with their role in crosslinking ER cisterns before the hypotonic lysis.
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PMC10197932
The results suggest that some lymphocytes maybe could have some fine mechanisms that control apoptotic events in different extents and ways, such as different expression patterns of anti-apoptotic proteins like Bcl-2 family or maybe downregulation of PUMA or NOXA, pro-apoptotic proteins, or P53 17,34,35, or maybe upregulating UCP2 (uncoupling protein 2) 31,41 which in turn lowers the levels of mitochondrial ROS, or maybe in the regulation of ERK1/2 pathways 42.
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PMC11653552
Patients with MM often present with various clinical manifestations including anemia, hypercalcemia, renal impairment, compromised immune function, and particularly osteolytic bone lesions that leads to an increased risk of fractures, contributing to heightened morbidity and mortality .
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PMC9621239
After culturing stable HCC cell lines for 24 h, total RNA was isolated from them using EasyPure RNA Kit (ER101, Transgen, China).
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PMC11585565
The results are from four independent experiments (n = 4). (
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PMC9429973
However, none of the patients had documented discussion of pain control education, any psychological support they may need nor were encouraged to use their own coping mechanisms for dealing with acute pain in their hospital notes.
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PMC10006224
This is one representative experiment of at least 3 performed.
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PMC11632064
Strikingly, the responses to BI-D1870 and LJH685 appeared to be compound- and cell line-specific (Fig 1D).
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PMC11283030
Flow cytometry (FCM) revealed that ACLY specific siRNA caused an increase in apoptotic rate of 786-O and A498 cells as compared to siRNA-NC at 24 h (P < 0.05; Fig. 4d), suggesting ACLY knockdown could induce ccRCC cell apoptosis.
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PMC9429973
In addition, luciferase was recombinantly expressed in all PDX models to allow repetitive monitoring of leukemia growth and treatment response using bioluminescence in vivo imaging (BLI).
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PMC11730320
F High levels of ICOS-1 expression by CD4+ memory T cells.
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PMC11541241
Jiao et al. (2023) identified the conserved TOR signalling pathway in S. sclerotiorum.
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PMC9429973
Modeled variables included clinical, laboratory, demographic, and pharmacological data.
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PMC9250505
Along with Olaparib, Rucaparib and Talazoparib were also approved for the treatment of ovarian cancer regardless of BRCA-mutational status.
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PMC3915447
Our data showed that the expression of antiapoptotic genes such as bcl-2, survivin of CCRF CEM cells were significantly down-regulated after co-treatment of FA with SPIO, whereas the expression of bax was up-regulated.
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PMC11026382
The reads passing these quality control criteria were compared against the wild-type reference sequence to determine mutation identify.
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PMC11786767
To generate the Ki67-miR knockdown constructs, an artificial miRNA was designed using BLOCK-iT™ RNAi Designer (https://rnaidesigner.thermofisher.com/rnaiexpress/).
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PMC11569208
For miRNA qPCR, the universal poly-A tail (Agilent) was used as the reverse primer.
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PMC7192625
Moreover, we confirmed an association of chromatin marks to chromatin structure that leads to preferential contacts between chromatin regions with similar chromatin (47).
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PMC11714165
The NBD‐T demonstrated a modest anti‐cancer activity (Figure 3G).
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PMC11684269
In line with previous studies, this process is independent of mTOR and AMPK (110).
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PMC10955424
The Adenomatous Polyposis Coli (APC)/ catenin/TCF pathway, that regulates cell division, angiogenesis, and apoptosis, is a significant depiction of such a system .
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PMC11143482
All parameters measured presented as mean ± SD obtained from three independent experiments where each procedure was performed in triplicates.
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PMC11377827
The reactions were washed three times in 1xPBS, lysed with 50 µl 2 x SDS and analysed by immunoblotting.
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