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OTAR3088
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BioData-CellLine_annotated

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PMC11609529
The identification of the YM fusion in various cancers suggests that it may act as a key driver in activating a common mechanism of tumorigenesis, thereby serving as both a valuable biomarker and a promising therapeutic target.
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PMC11412752
RNA was reverse transcribed by RT Reagent Kit (RR047A; Takara).
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PMC9960565
A hygroscopic “greenish-yellow” solid was obtained with a 35% of yield (0.13 g).
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PMC9895440
The in vivo anti-tumor efficacy of adoptively transferred murine TCR transgenic T cells was improved by Snx9 KO, which correlated with increased effector-memory-like differentiation, enhanced chemokine expression, and elevated IFNγ serum levels.
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PMC11676670
To confirm the authenticity and purity, we conducted short tandem repeat (STR) profiling of OVAR79 cells at the 20th passage and showed that this line is unique and uncontaminated (Figure 1A).
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PMC5025404
Hundred microliter of the cell suspension was added to every well of a 96-well plate, using 30–40 plates for each dilution.
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PMC11626627
EMT-related genes were screened using qRT-PCR in 786-O cells transfected with miR-204–3p inhibitor compared to the negative control (NC) (D), and miR-204–3p mimic compared to NC (E). (
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PMC11266100
It is widely acknowledged that primary factors influencing the effectiveness of electroporation include electric field strength, pulse number, pulse duration, and applied frequency.
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PMC10079526
TAK981 (Chemietek, Indianapolis, IN, USA) was dissolved in DMSO for in vitro usage and in 20% (2-Hydroxypropyl)-β-cyclodextrin (HPBCD, Merck, Darmstadt, Germany) for in vivo purposes.
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PMC11779960
Firstly, unproductive rearrangement of the excluded TCRβ locus is common, and WGS/ WES do not discriminate productive and non-productive chains.
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PMC11502327
All these results suggest that nanoscale drug delivery systems are a promising prospect for therapeutic targeted intervention in OC.
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PMC9429973
Patients treated with G-CHOP had statistically significantly superior OS and PFS compared to patients treated with G-B (P=0.002 and P=0.006, respectively, Fig. 1).
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PMC8270637
Moreover, the flow cytometry results showed that the apoptosis of TGF-β1-treated T cells was increased after co-culture with HCC cells.
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PMC9424261
G Endogenous MDM2 was immunoprecipitated by anti-MDM2 antibody and ubiquitination of MDM2 were measured by anti-ubiquitin antibody in Bel-7404 and Bel-7402 cells with or without HERPUD1 knocked out.
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PMC9429973
Dose limiting toxicities (DLTs) will be assessed during the first 28 days of continuous treatment, not including the PK period.
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PMC9429973
Results: From registration: 143 eligible patients were included in the study.
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PMC10968586
HT-dependent anti-inflammatory effect was also mediated by HT-elicited increase in protein levels of PPARγ.
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PMC8481254
Overall, this finding suggests that CA negatively regulates CDK19 to reduce the cellular O-GlcNAcylation level and suppress the proliferative capacity of liver cancer cells.
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PMC9429973
No unexpected toxicities were observed.
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PMC11342785
We next tested the effects of manipulating the strength of the TPPP MT binding component on synMAP trigger circuit behavior (Fig. 6E).
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PMC11391695
A The structures of PEI/NPs@M, nc/PEI/NPs@M and pcDNA/PEI/NPs@M were observed by transmission electron microscopy (TEM); B the cytotoxicity of PBS, Cy3/pcDNA/PEI/NPs, Cy3/PEI/NPs@M and Cy3/pcDNA/PEI/NPs@M complexes was tested using CCK-8 assay; C the particle uptake efficiencies of Cy3/pcDNA/PEI/NPs, Cy3/PEI/NPs@M and Cy3/pcDNA/PEI/NPs@M complex were measured by flow cytometry; D, E fluorescence imaging revealed that more Cy3/pcDNA/PEI/NPs@M nanocomposites were concentrated in the liver area, and their targeting ability was more superior than that of Cy3/pcDNA/PEI/NPs.
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PMC11087055
Thus, these results support a model that mitosis is coupled with PS morphogenesis but is not necessarily required for the initiation and early phase of the polonaise movements.
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PMC9429973
There was no family or personal history of hemorrhage, especially during circumcision and dental extractions.
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PMC11320834
The above results also indicate the need to optimize the composition of the TLL and OLL further to provide improved long-term stability.
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PMC9581083
Further evaluations are needed to explore the clinical efficacy of TCM against COVID-19, potential molecular mechanisms that improve multiple organ damage, and use various modern scientific techniques to determine the material basis of possible drugs.
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PMC11599565
Panel C: Inducible expression of stem cell related markers upon cisplatin exposure.
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PMC11629192
The serum anti-NMDAR antibody was negative.
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PMC7039683
Scatter plots showing the ATAC-seq signal correlation between two biological replicates.
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PMC11354225
Three areas per well were photographed (using an objective with 20× magnification), every 12 h, for a total of 36 h, using TissueFAXS i Plus Cytometer Microscopy (TissueGnostics, Vienna, Austria).
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PMC3765139
Fang described a subset of cells derived from freshly isolated or in vitro stabilized melanoma cell lines that was able to form “melanoma spheroids” when grown in a specific stem cell medium.
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PMC9429973
We aim to evaluate the factors that may impact on the timely delivery of haematological care for this cohort of patients.
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PMC11787355
Moreover, additional irradiation of tumor cells in vitro resulted in increased lysis of target cells likely due to enhanced activation of PTPRZ1-TCR-CD4-T but not PTPRZ1-TCR-CD8-T (Fig. 3d, e, Supplementary Fig. 5e–h and Supplementary Fig. 6c–f).
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PMC9429973
Among others, oncogenes such as c-MYC or ETS-1 (D) have been identified.
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PMC11509278
These cells were washed with 4 °C PBS (pH 7.2–7.4) 3 times after 48 h of incubation.
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PMC11676670
Images of the cells were taken immediately after insert removal, and then after 8 and 24 h, using an Olympus IX53F (Olympus, Tokyo, Japan) fluorescence microscope.
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PMC11748335
Indeed, there is an antagonistic relationship between H3K27me3 peaks and DNA methylation, with a negative correlation in intensity and limited genomic overlap .
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PMC11770199
Two gene sets related to apoptosis were significantly enriched: “Apoptosis by Reovirus infection up“ and ”Modulation and signaling of apoptosis”.
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PMC8750422
Under normal conditions, NO synthesized by eNOS in endothelial cells regulate anti-oxidative and anti-inflammatory responses .
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PMC11746942
Further examination of S1P signaling in psoriasis using publicly available single-cell RNA-sequencing data revealed distinct localization patterns of S1P receptors in psoriatic lesions (https://yz-studio.shinyapps.io/psoriaticskincellatlas2/).
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PMC9429973
Of the baseline characteristics of the disease, the most frequent symptom was asthenia/adynamia (45%), 17% had a history of thrombosis at the time of diagnosis and 20% described bone marrow dysplasia.
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PMC7759933
Live/Dead staining enabled us to investigate at which initial density and time of cultivation the viability of cells started to decrease and consequently, form the necrotic core.
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PMC9952933
The absorption of the samples was normalized to cell numbers using a parallel second plate.
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PMC11772449
In addition to these tumors mentioned above, PFD has also been confirmed in many studies to inhibit the growth and proliferation of various tumor cells, such as leiomyoma and glioma, demonstrating its anticancer potential (Kozono et al., 2013; Lee et al., 1998; Burghardt et al., 2007).
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PMC9429973
1 patient was refractory to treatment and progressed after 2 cycles.
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PMC11180402
Further study demonstrated that ectopic expression of DNMT3b reversed the ISO-mediated inhibition of BMIBC cell invasion and anchorage-independent growth of 5637 cells (Fig. 6E-H).
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PMC11513011
Fig. 2Apoptosis-inducing effect of DIB by flow cytometry analysis.
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PMC11365427
The distal femur and lumbar vertebrae of the mice were scanned with a high-resolution micro-CT system (Siemens Inveon MM GANTRY, Germany).
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PMC8358176
Subsequently, the cells were seeded (2 × 10 cells.
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PMC11609529
After 14 days of culture, colonies were rinsed with 1× PBS, fixed with 100% ethanol, and stained with 0.25% crystal violet (in ethanol).
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PMC11747467
According to the manufacturer’s instructions, the cells were cultured in their respective media, each supplemented with fetal bovine serum and penicillin–streptomycin.
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PMC11746948
Genetic silencing or pharmacological inhibition of APT2 with ML349 increases GPX4 palmitoylation, thereby stabilizing the protein and conferring resistance to ferroptosis.
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PMC4112127
For each patient with CC, tissues from the primary CC tumor were compared with matched non-malignant bile duct epithelial control samples from their own resection specimen.
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PMC10994876
Both real-time PCR and western immunoblot analysis validated the successful upregulation of YAP expression a Real-time analysis of YAP mRNA levels following overexpression of mutant YAP compared to control EPO-CHO cells.
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PMC11469524
Consensus network structure and coefficient quantification of links present in at least 3 of the 4 modelled cell lines with chronic (HBl-1, OCI-LY3) and acute (BL-2, BL-41) BCR signaling.
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PMC9119314
The semi-synthetic analogue 4 was of similar activity to 1, while 3, 5, and 6 were 1.8-3-fold more potent than 1 (Table 1).
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PMC9509578
Elimination of CSCs via nanoformulations is one promising approach to overcoming MDR.
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PMC11648299
All P‐values were two sided, and P < 0.05 was considered as statistically significant.
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PMC11721587
Bracket indicates SUMOylated Ulk3. (
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bracket", "indicates", "SUMOylated", "Ulk3", ".", "(" ] } ]
PMC7868205
A ratio larger than 4 is usually desired.
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PMC11087055
F-G’’’) Trace of cell flow path with Flowtrace analysis (green is trace, yellow indicates endpoint) of fluorescently-tagged epiblast cells.
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PMC11697189
To explore the prediction ability of the model, we applied it to the entire cohort and the testing cohort.
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PMC2614415
SAM analysis estimated the False Discovery Rate for all genes to be 0.
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PMC11477621
HRMS (ESI), m/z: calcd for C16H21N2O2: 273.1609 [M − H]; found: 273.1608.
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PMC5874706
For measuring the loading efficiency , after the formation of nanoparticle suspensions, unbound THN7 molecules in the nanoparticle dispersions were separated by centrifugation at 50,000 rpm for 1 h at +4 °C by an Optima™ MAX-E centrifuge (Beckman-Coulter), in order to settle down the loaded nanoparticles.
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PMC10578720
DCA treatment enhances the immune responses of macrophages in the chronic HBV-infected mouse model. (
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PMC11001582
Non-neurological control and C9orf72 iPS cells were obtained from the Answer ALS repository at Cedars Sinai (see Supplementary Table 1 for demographics) and maintained in mTeSR Plus medium at 37 °C with 5% CO2.
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PMC8973725
Expression of ZNF677 in 533 ccRCC tissues and 72 normal tissues from the TCGA database. (
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PMC10094712
However, a weak point in this area of biology is the study of the functions of selenoproteins, of which 25 have been identified in mammals to date.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "weak", "point", "in", "this", "area", "of", "biology", "is", "the", "study", "of", "the", "functions", "of", "selenoproteins", ",", "of", "which", "25", "have", "been", "identified", "in", "mammals", "to", "date", "." ] } ]
PMC11756514
The neck region facilitates trimerization of the proteins through coiled coils of alpha helices (8, 9).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "neck", "region", "facilitates", "trimerization", "of", "the", "proteins", "through", "coiled", "coils", "of", "alpha", "helices", "(", "8", ",", "9", ")", "." ] } ]
PMC9429973
Gastrointestinal disturbance occurred in 12% (3/26) patients, 1 required admission with G4 diarrhoea and remaining cases were G1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gastrointestinal", "disturbance", "occurred", "in", "12", "%", "(", "3/26", ")", "patients", ",", "1", "required", "admission", "with", "G4", "diarrhoea", "and", "remaining", "cases", "were", "G1", "." ] } ]
PMC11506827
no. sc-7382), β-actin (cat.
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PMC11438317
In this case, LYP did not prevent luciferase induction (Fig. 4B).
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PMC10969097
In addition to deciphering the cellular mechanism behind mushroom extracts’ properties, we also aimed to select clinical studies using mushroom extracts as a complement to cancer treatment, as a strategy to increase the effect of chemotherapy.
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PMC11271800
By evading CD8 cells, LINC01232 can promote immune escape of glioma cells, miR-23a-3p enhances hepatocellular carcinoma (HCC) metastasis by promoting epithelial-mesenchymal transition (EMT), angiogenesis, and vascular permeability.
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PMC9429973
There are several most used conditioning regimens, previous EBMT recommendations recommended the use of ‘intermediate intensity’ regimen namely cyclophosphamide 200 mg/kg with T-cell depleting.
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PMC11633763
Representative images of HK2 staining in 30 paired osteosarcoma (OS) and noncancer tissues. (
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PMC11704834
The thermocycling conditions were as follows: reverse transcription reaction was 10 min at 50˚C, polymerase activation and DNA denaturation was 1 min at 95˚C, and then amplification; denaturation for 10 sec at 95˚C, annealing/extension for 30 sec at 60˚C, and run for 40 cycles.
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PMC11740508
At least 500 cells per group examined.
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PMC11757230
Therefore, the application of MSC-based therapy for CIE could potentially influence the progression of undiagnosed intestinal lymphomas.
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PMC11129910
The age at the time of diagnosis was recorded in years.
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PMC9429973
Secondary transplants from PDX1 showed 12.5% of hCD45+ cells at 16 weeks in peripheral blood, with average spleen weight of 168 g, with a similar immunephenotype as primary mice, and were transplanted into tertiary mice.
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PMC11751675
Notably, the mechanism of action of SLs has been correlated to α-methylene-γ-lactone and α,β-unsaturated cyclopentenone that act as alkylating agents on cellular proteins via Michael addition, particularly targeting their thiol groups.
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PMC9429973
In the global Phase 3, randomized ZUMA-7 study, axi-cel, an autologous anti-CD19 CAR T-cell therapy, significantly improved event-free survival (EFS; hazard ratio [HR], 0.398, P<0.0001; median 8.3 vs 2 months, respectively) compared with second-line SOC in R/R LBCL (Locke FL, et al. N Engl J Med.
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PMC9429973
Patients will be randomized in a 1:1 ratio to receive second line treatment at MRD relapse in arm A or at PD in arm B. Randomization will be stratified by R-ISS stage at diagnosis and single versus tandem transplant.
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PMC7334607
We produced a temporal collateral sensitivity map to examine the drug sensitivity assays for nine of these drugs through time in the A673 cell line (see Figure 2).
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PMC11337594
Interestingly, this reduction in cell number is not due to apoptosis but to necrosis.
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PMC11322866
Studies have suggested that ERK1/2 promotes cellular senescence .
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PMC5415764
Moreover, the decoration of targeting ligands on nanoparticles (NPs) to recognize specific receptors overexpressed on tumor cell surface can maximize drug delivery to the tumor site and effectively overcome tumor drug resistance2122.
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PMC11344246
Small molecule inhibition of CDK1 reduced viability in MOC cell lines JHOM-1 and MCAS, displaying an IC50 of 3 and 2.4 μM, respectively for these two cell lines (Figure 4A).
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PMC4443654
Here we exploit the unprecedented volumes of data produced recently to provide an integrated and rigorously quantitative view of locus-level chromatin features, higher-order chromatin structure and nuclear organization across three cell types.
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PMC9429973
His last blood count is strictly normal and he has not been transfused in the last 6 months.
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PMC9429973
Patients on the weekly regime received more VTD cycles and a higher cumulative dose (p=0.044).
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PMC11695546
Some biological tests were done including antibacterial action versus Helicobacter pylori, anti-biofilm activity versus H. pylori, anti-hemolytic activity in the existence of H. pylori, anti-Alzheimer action, and cytotoxic effect towards A-413 cancer cell line to determine the activity of coconut oil and upon exposure to ozone.
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PMC11585565
Quantification of wild-type and mutant CNNM4 protein expression levels following cycloheximide treatment at 0, 2, 4, 8, 12, and 24 h. FLAG-tagged CNNM4 protein band intensities were normalized to GAPDH.
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PMC11746942
After deparaffinization, the skin samples were cut into 10 μm-thick slices.
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PMC11806182
Interestingly, we used miWalk to confirm the associations of these miR-target gene pairs (data not shown) .
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PMC11703992
Additionally, the significantly differentially activated metabolic pathways between DDIT4 ± and ARHGAP15 ± groups mainly involve the metabolism of glutamine, the citrate cycle, and sucrose levels.
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PMC11777207
Since B7 mice lack both CD80 and CD86, we crossed KikGR mice with Cd80 mice to interrogate the role of CD80 alone in dermal DC migration (fig. S3A).
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PMC5833712
In contrast, loss or inhibition of SIRT1 deacetylase activity restored ligand-activated ERβ functionality.
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PMC11711347
Absorbance was measured using resazurin and resorufin absorbance spectra at a wavelength of 570 nm using a multimode reader.
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