Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC10890307
Because MCF-7 has been reported to consume lactate under normoxia , and it has not been previously reported whether lung cancer cells can consume lactate, we included MCF-7 as a positive control.
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "MCF-7", "has", "been", "reported", "to", "consume", "lactate", "under", "normoxia", ",", "and", "it", "has", "not", "been", "previously", "reported", "whether", "lung", "cancer", "cells", "can", "consume", "lactate", ",", "we", "included", "MCF-7", "as", "a", "positive", "control", "." ] } ]
PMC9429973
The main objective of our study was to determine the impact of hematologic disease status on 30-day mortality and on a composite outcome of severe complications(AKI, ARDS, and liver failure).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "objective", "of", "our", "study", "was", "to", "determine", "the", "impact", "of", "hematologic", "disease", "status", "on", "30-day", "mortality", "and", "on", "a", "composite", "outcome", "of", "severe", "complications(AKI", ",", "ARDS", ",", "and", "liver", "failure", ")", "." ] } ]
PMC11052306
Additional biological experiments were carried out to determine the mechanism of action of both dendrimers 2-G3 and 2-G3-Cu48.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "biological", "experiments", "were", "carried", "out", "to", "determine", "the", "mechanism", "of", "action", "of", "both", "dendrimers", "2-G3", "and", "2-G3-Cu48", "." ] } ]
PMC9429973
TEAEs leading to Cami dose delay/reduction or discontinuation occurred in 66 (56.4%) and 32 (27.4%) pts, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TEAEs", "leading", "to", "Cami", "dose", "delay/reduction", "or", "discontinuation", "occurred", "in", "66", "(", "56.4", "%", ")", "and", "32", "(", "27.4", "%", ")", "pts", ",", "respectively", "." ] } ]
PMC10607604
As cell migration and invasiveness are associated with epithelial–mesenchymal transition (EMT), we used RT-qPCR to measure the expression of four transcription factors that drive EMT (SLUG, SNAIL, ZEB-1, and ZEB-2) and of desmoplakin (DPK), an epithelial cell–cell junction marker.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "cell", "migration", "and", "invasiveness", "are", "associated", "with", "epithelial", "–", "mesenchymal", "transition", "(", "EMT", ")", ",", "we", "used", "RT-qPCR", "to", "measure", "the", "expression", "of", "four", "transcription", "factors", "that", "drive", "EMT", "(", "SLUG", ",", "SNAIL", ",", "ZEB-1", ",", "and", "ZEB-2", ")", "and", "of", "desmoplakin", "(", "DPK", ")", ",", "an", "epithelial", "cell", "–", "cell", "junction", "marker", "." ] } ]
PMC11765988
SLR can mainly be seen in lymphoma and testicular cancer .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SLR", "can", "mainly", "be", "seen", "in", "lymphoma", "and", "testicular", "cancer", "." ] } ]
PMC11604015
In an ongoing phase I/II clinical trial (NCT03590574), AUTO4, a TRBC1-targeted autologous CAR-T cell, showed good antitumor activity and safe prolife in selected patients with TRBC1-expressed PTCL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "an", "ongoing", "phase", "I/II", "clinical", "trial", "(", "NCT03590574", ")", ",", "AUTO4", ",", "a", "TRBC1-targeted", "autologous", "CAR-T", "cell", ",", "showed", "good", "antitumor", "activity", "and", "safe", "prolife", "in", "selected", "patients", "with", "TRBC1-expressed", "PTCL", "." ] } ]
PMC11126803
D, Human Cancer Database results show that the expression of LncRNA-SERB in primary RCC tumors is higher than that in normal tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "Human", "Cancer", "Database", "results", "show", "that", "the", "expression", "of", "LncRNA-SERB", "in", "primary", "RCC", "tumors", "is", "higher", "than", "that", "in", "normal", "tissues", "." ] } ]
PMC5963610
We hypothesized that enrichment of NGcGM3 expression in tumors relates to advantages of this ganglioside, on ensuring both EGFR and uPAR pathways optimal function.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "hypothesized", "that", "enrichment", "of", "NGcGM3", "expression", "in", "tumors", "relates", "to", "advantages", "of", "this", "ganglioside", ",", "on", "ensuring", "both", "EGFR", "and", "uPAR", "pathways", "optimal", "function", "." ] } ]
PMC9927933
Consistently, ectopic expression of UBE2C at a level equal to or lower than endogenous levels activated both MAPK and mTORC1/2 signaling, with a moderate reduction in DEPTOR levels (Figure 3B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistently", ",", "ectopic", "expression", "of", "UBE2C", "at", "a", "level", "equal", "to", "or", "lower", "than", "endogenous", "levels", "activated", "both", "MAPK", "and", "mTORC1/2", "signaling", ",", "with", "a", "moderate", "reduction", "in", "DEPTOR", "levels", "(", "Figure", "3B", ")", "." ] } ]
PMC9024365
The stratification of GluA2 populations co-localized or not co-localized with SD4-NTD/IF-M resulted in no change in the mean size of GluA2 clusters (Figure 2G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "stratification", "of", "GluA2", "populations", "co-localized", "or", "not", "co-localized", "with", "SD4-NTD/IF-M", "resulted", "in", "no", "change", "in", "the", "mean", "size", "of", "GluA2", "clusters", "(", "Figure", "2", "G", ")", "." ] } ]
PMC10654497
Protein–protein interactions between SFRGs. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "–", "protein", "interactions", "between", "SFRGs", ".", "(" ] } ]
PMC9429973
The study will describe the treatment pathways among adult patients as a primary endpoint.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "will", "describe", "the", "treatment", "pathways", "among", "adult", "patients", "as", "a", "primary", "endpoint", "." ] } ]
PMC9429973
Among pts with HDCT/HSCT, the most common 2L treatments were rituximab plus ifosfamide, carboplatin, and etoposide (R-ICE)-based (72.5%) and rituximab plus gemcitabine, dexamethasone, and cisplatin (6.3%); the most common third-line (3L) treatments were bendamustine plus rituximab (BR; 12.2%) and lenalidomide plus rituximab (12.2%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "pts", "with", "HDCT/HSCT", ",", "the", "most", "common", "2L", "treatments", "were", "rituximab", "plus", "ifosfamide", ",", "carboplatin", ",", "and", "etoposide", "(R-ICE)-based", "(", "72.5", "%", ")", "and", "rituximab", "plus", "gemcitabine", ",", "dexamethasone", ",", "and", "cisplatin", "(", "6.3", "%", ")", ";", "the", "most", "common", "third-line", "(", "3L", ")", "treatments", "were", "bendamustine", "plus", "rituximab", "(", "BR", ";", "12.2", "%", ")", "and", "lenalidomide", "plus", "rituximab", "(", "12.2", "%", ")", "." ] } ]
PMC11422497
Conversely, miR-494-3p expression of xenograft tumor samples exhibited a significant downregulation in the circ_SMA4 overexpressing group and a substantial upregulation in the sh-circ_SMA4 group (P < 0.05; Fig. 8G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "miR-494", "-", "3p", "expression", "of", "xenograft", "tumor", "samples", "exhibited", "a", "significant", "downregulation", "in", "the", "circ_SMA4", "overexpressing", "group", "and", "a", "substantial", "upregulation", "in", "the", "sh-circ_SMA4", "group", "(", "P", "<", "0.05", ";", "Fig.", "8", "G", ")", "." ] } ]
PMC8592717
PCA has been reported to increase the nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression and transcription activity; modulate the cellular redox status with the upregulated expression of hallmark antioxidant enzymes, including heme oxygenase-1(HO-1), SOD, and catalase (CAT); and decrease the levels of MDA-treated PC12 cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "PCA", "has", "been", "reported", "to", "increase", "the", "nuclear", "factor", "erythroid", "2-related", "factor", "2", "(", "Nrf2", ")", "protein", "expression", "and", "transcription", "activity", ";", "modulate", "the", "cellular", "redox", "status", "with", "the", "upregulated", "expression", "of", "hallmark", "antioxidant", "enzymes", ",", "including", "heme", "oxygenase-1(HO-1", ")", ",", "SOD", ",", "and", "catalase", "(", "CAT", ")", ";", "and", "decrease", "the", "levels", "of", "MDA-treated", "PC12", "cells", "." ] } ]
PMC9261184
Methane slip rates are higher across the generator engines than anticipated in a previous research, and high variability was also demonstrated in the results: for example, generator engine G4 produced 16% slip (the uncombusted methane as a percentage of the methane throughput of the engine), double that of G1 (8%, which is the same model and power rating).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methane", "slip", "rates", "are", "higher", "across", "the", "generator", "engines", "than", "anticipated", "in", "a", "previous", "research", ",", "and", "high", "variability", "was", "also", "demonstrated", "in", "the", "results", ":", "for", "example", ",", "generator", "engine", "G4", "produced", "16", "%", "slip", "(", "the", "uncombusted", "methane", "as", "a", "percentage", "of", "the", "methane", "throughput", "of", "the", "engine", ")", ",", "double", "that", "of", "G1", "(", "8", "%", ",", "which", "is", "the", "same", "model", "and", "power", "rating", ")", "." ] } ]
PMC11650848
Having established that both SNPs act as mQTLs, we examined samples from the children at 11 years to determine if the levels of methylation associated with each haplotype were similar.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Having", "established", "that", "both", "SNPs", "act", "as", "mQTLs", ",", "we", "examined", "samples", "from", "the", "children", "at", "11", "years", "to", "determine", "if", "the", "levels", "of", "methylation", "associated", "with", "each", "haplotype", "were", "similar", "." ] } ]
PMC11481779
The second heatmap shows the output of the model with chr8:32 750 000–32 950 000 replaced by a sequence of chr8:33 450 000–33 650 000 The final analysis that we have undertaken was the question - how well would our method perform on different organisms?
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second", "heatmap", "shows", "the", "output", "of", "the", "model", "with", "chr8:32", "750", "000–32", "950", "000", "replaced", "by", "a", "sequence", "of", "chr8:33", "450", "000–33", "650", "000", "The", "final", "analysis", "that", "we", "have", "undertaken", "was", "the", "question", "-", "how", "well", "would", "our", "method", "perform", "on", "different", "organisms", "?" ] } ]
PMC6379402
The challenge is how to integrate them within a unified conceptual and computational framework enabling new discoveries.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "challenge", "is", "how", "to", "integrate", "them", "within", "a", "unified", "conceptual", "and", "computational", "framework", "enabling", "new", "discoveries", "." ] } ]
PMC10812665
The likely explanation at present is a very low bioavailability of Ber, and a strong hepatic metabolism that eliminates the toxicant .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "likely", "explanation", "at", "present", "is", "a", "very", "low", "bioavailability", "of", "Ber", ",", "and", "a", "strong", "hepatic", "metabolism", "that", "eliminates", "the", "toxicant", "." ] } ]
PMC9581083
For those in home isolation, TCM can be used to prevent and avoid severe illness.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "those", "in", "home", "isolation", ",", "TCM", "can", "be", "used", "to", "prevent", "and", "avoid", "severe", "illness", "." ] } ]
PMC9895440
Transcript counts per cell were used for downstream analysis in R version 4.2.1 (within R Studio for Mac 2022.07.01) using Seurat_4.1.1, scater_1.24.0, viridis_0.6.2, future_1.27.0, dittoSeq_1.8.1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transcript", "counts", "per", "cell", "were", "used", "for", "downstream", "analysis", "in", "R", "version", "4.2.1", "(", "within", "R", "Studio", "for", "Mac", "2022.07.01", ")", "using", "Seurat_4.1.1", ",", "scater_1.24.0", ",", "viridis_0.6.2", ",", "future_1.27.0", ",", "dittoSeq_1.8.1", "." ] } ]
PMC9221284
Minor bands corresponding to the phosphorylated forms were also detected.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Minor", "bands", "corresponding", "to", "the", "phosphorylated", "forms", "were", "also", "detected", "." ] } ]
PMC11025866
The induction of BZLF1 by NaB after 24 h was blocked by the addition of VPM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "induction", "of", "BZLF1", "by", "NaB", "after", "24", "h", "was", "blocked", "by", "the", "addition", "of", "VPM", "." ] } ]
PMC11345828
Gratifyingly, both 19 and 20 showed a 2-fold improvement in the mouse IV clearance from (M)-18.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gratifyingly", ",", "both", "19", "and", "20", "showed", "a", "2-fold", "improvement", "in", "the", "mouse", "IV", "clearance", "from", "(M)-18", "." ] } ]
PMC11632064
All other doses are relative to this average value and thus are represented as %.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "other", "doses", "are", "relative", "to", "this", "average", "value", "and", "thus", "are", "represented", "as", "%", "." ] } ]
PMC11765243
As noted above, the expression of p110α or p110δ catalytic subunits was not significantly different in lysates of CD4 T spleen cells from WT and p110αKD-T mice (Figure S4D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "noted", "above", ",", "the", "expression", "of", "p110α", "or", "p110δ", "catalytic", "subunits", "was", "not", "significantly", "different", "in", "lysates", "of", "CD4", "T", "spleen", "cells", "from", "WT", "and", "p110αKD-T", "mice", "(", "Figure", "S4D", ")", "." ] } ]
PMC11732635
The gray line indicates the EBV-DNA-negative reference range of <5×10 copies/mL. After the second discharge on October 12, 2022 (day 35 after infusion), regular checkups showed that the EBV-DNA count remained undetectable.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gray", "line", "indicates", "the", "EBV-DNA-negative", "reference", "range", "of", "<", "5", "×", "10", "copies/mL.", "After", "the", "second", "discharge", "on", "October", "12", ",", "2022", "(", "day", "35", "after", "infusion", ")", ",", "regular", "checkups", "showed", "that", "the", "EBV-DNA", "count", "remained", "undetectable", "." ] } ]
PMC11637276
In addition, α2β1 integrin has been shown to regulate melanoma and pancreatic carcinoma cell migration , as well as bone metastatic dissemination of prostate and breast cancer cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "α2β1", "integrin", "has", "been", "shown", "to", "regulate", "melanoma", "and", "pancreatic", "carcinoma", "cell", "migration", ",", "as", "well", "as", "bone", "metastatic", "dissemination", "of", "prostate", "and", "breast", "cancer", "cells", "." ] } ]
PMC6182045
The results described herein document the availability of a novel cell line for the large-scale production of clade C gp120 for clinical trials.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "described", "herein", "document", "the", "availability", "of", "a", "novel", "cell", "line", "for", "the", "large-scale", "production", "of", "clade", "C", "gp120", "for", "clinical", "trials", "." ] } ]
PMC11473843
All the mouse experiments were randomized.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "mouse", "experiments", "were", "randomized", "." ] } ]
PMC9164404
Besides, we also compared the killing effect of Abplatin with previously published drugs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "we", "also", "compared", "the", "killing", "effect", "of", "Abplatin", "with", "previously", "published", "drugs", "." ] } ]
PMC9429973
The presence of CH is not associated with high or low myeloid skewing.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "CH", "is", "not", "associated", "with", "high", "or", "low", "myeloid", "skewing", "." ] } ]
PMC11674891
Moreover, our results indicate that the AKT signaling pathway plays a key role in regulating these target genes in response to GRPR activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "our", "results", "indicate", "that", "the", "AKT", "signaling", "pathway", "plays", "a", "key", "role", "in", "regulating", "these", "target", "genes", "in", "response", "to", "GRPR", "activation", "." ] } ]
PMC11023271
Data were pooled from two independent experiments, with each condition tested in quadruplicate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "pooled", "from", "two", "independent", "experiments", ",", "with", "each", "condition", "tested", "in", "quadruplicate", "." ] } ]
PMC9065483
Cores were infected 4 h later with 3e4 plaque forming units (pfu) of VSVΔ51-GFP per core. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cores", "were", "infected", "4", "h", "later", "with", "3e4", "plaque", "forming", "units", "(", "pfu", ")", "of", "VSVΔ51-GFP", "per", "core", ".", "(" ] } ]
PMC10529414
Through aberrant transcriptional regulation of various tumor suppressor genes and oncogenes, TFs act as drivers to orchestrate tumor initiation and progression and are thus attractive research focuses for the identification of biomarkers and therapeutic targets.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "aberrant", "transcriptional", "regulation", "of", "various", "tumor", "suppressor", "genes", "and", "oncogenes", ",", "TFs", "act", "as", "drivers", "to", "orchestrate", "tumor", "initiation", "and", "progression", "and", "are", "thus", "attractive", "research", "focuses", "for", "the", "identification", "of", "biomarkers", "and", "therapeutic", "targets", "." ] } ]
PMC2777936
Only 3 of the 5 FZD7 constructs appreciably repressed FZD7 mRNA and these were FZD7-2, FZD7-3 and FZD7-4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "3", "of", "the", "5", "FZD7", "constructs", "appreciably", "repressed", "FZD7", "mRNA", "and", "these", "were", "FZD7", "-", "2", ",", "FZD7", "-", "3", "and", "FZD7", "-", "4", "." ] } ]
PMC10033453
Serial 2-fold dilutions of IFNβ (human: PBL Assay Science, Piscataway, NJ, USA; mouse: R&D Systems) were added across the plate, and serial 10-fold dilutions of VMG were added down the plate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serial", "2-fold", "dilutions", "of", "IFNβ", "(", "human", ":", "PBL", "Assay", "Science", ",", "Piscataway", ",", "NJ", ",", "USA", ";", "mouse", ":", "R&D", "Systems", ")", "were", "added", "across", "the", "plate", ",", "and", "serial", "10-fold", "dilutions", "of", "VMG", "were", "added", "down", "the", "plate", "." ] } ]
PMC11686380
The variant GAP43 protein was unstable in primary cultured cortical neurons and hippocampal neurons in vitro.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "variant", "GAP43", "protein", "was", "unstable", "in", "primary", "cultured", "cortical", "neurons", "and", "hippocampal", "neurons", "in", "vitro", "." ] } ]
PMC9429973
Additionally, the statistically significant effects of these genotypes on survival were examined.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "statistically", "significant", "effects", "of", "these", "genotypes", "on", "survival", "were", "examined", "." ] } ]
PMC11754094
Here we show that Cas9-mediated double-strand breaks induce large deletions at varying frequencies in cancer cell lines, human embryonic stem cells and human primary T cells, and that most deletions are produced by two repair pathways: end resection and DNA-polymerase theta-mediated end joining.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "show", "that", "Cas9-mediated", "double-strand", "breaks", "induce", "large", "deletions", "at", "varying", "frequencies", "in", "cancer", "cell", "lines", ",", "human", "embryonic", "stem", "cells", "and", "human", "primary", "T", "cells", ",", "and", "that", "most", "deletions", "are", "produced", "by", "two", "repair", "pathways", ":", "end", "resection", "and", "DNA-polymerase", "theta-mediated", "end", "joining", "." ] } ]
PMC9429973
Results: We use computer simulations to show that TKI dose reduction prior to treatment cessation appears as an equally efficient approach to achieve high levels of CML patients remaining in TFR compared to full dose treatment for the same duration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "use", "computer", "simulations", "to", "show", "that", "TKI", "dose", "reduction", "prior", "to", "treatment", "cessation", "appears", "as", "an", "equally", "efficient", "approach", "to", "achieve", "high", "levels", "of", "CML", "patients", "remaining", "in", "TFR", "compared", "to", "full", "dose", "treatment", "for", "the", "same", "duration", "." ] } ]
PMC10093184
The established D-17 cell line served as a reference.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "established", "D-17", "cell", "line", "served", "as", "a", "reference", "." ] } ]
PMC11763126
The pull-down products were separated by gel electrophoresis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pull-down", "products", "were", "separated", "by", "gel", "electrophoresis", "." ] } ]
PMC11534035
In breast and ovarian cancer cell lines, Whitley found that overexpression of wild type PAI1 via adenovirus transfection, led to decreased motility and invasive character of the cells (11).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "breast", "and", "ovarian", "cancer", "cell", "lines", ",", "Whitley", "found", "that", "overexpression", "of", "wild", "type", "PAI1", "via", "adenovirus", "transfection", ",", "led", "to", "decreased", "motility", "and", "invasive", "character", "of", "the", "cells", "(", "11", ")", "." ] } ]
PMC11703992
GAPDH was chosen as the internal control (Beyotime, QH00009S).Table 4The primers used in researchPrimerSequence or manufacturerIL-1βBeyotime, QH03645SIL-2Beyotime, QH03645SIL-6Beyotime, QH03645SIL-17ABeyotime, QH03769STNF-αBeyotime, QH05997SDDIT4Beyotime, QH08689S The primers used in research To detect the expression of selected genes, the proteins were extracted from Jurkat cells after centrifugation and lysis in RIPA-PMSF (RIPA Lysis Buffer, PMSF Solution (100 mM), Beyotime, P0013C, ST507) buffer on ice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "was", "chosen", "as", "the", "internal", "control", "(", "Beyotime", ",", "QH00009S).Table", "4The", "primers", "used", "in", "researchPrimerSequence", "or", "manufacturerIL-1βBeyotime", ",", "QH03645SIL-2Beyotime", ",", "QH03645SIL-6Beyotime", ",", "QH03645SIL-17ABeyotime", ",", "QH03769STNF-αBeyotime", ",", "QH05997SDDIT4Beyotime", ",", "QH08689S", "The", "primers", "used", "in", "research", "To", "detect", "the", "expression", "of", "selected", "genes", ",", "the", "proteins", "were", "extracted", "from", "Jurkat", "cells", "after", "centrifugation", "and", "lysis", "in", "RIPA-PMSF", "(", "RIPA", "Lysis", "Buffer", ",", "PMSF", "Solution", "(", "100", "mM", ")", ",", "Beyotime", ",", "P0013C", ",", "ST507", ")", "buffer", "on", "ice", "." ] } ]
PMC11756937
Our results demonstrate that the SeV reprogramming method leads to a significantly higher reprogramming success rate (92.0%) compared to the episomal reprogramming method (38.5%) regardless of source material (Figure 3A and Table 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "demonstrate", "that", "the", "SeV", "reprogramming", "method", "leads", "to", "a", "significantly", "higher", "reprogramming", "success", "rate", "(", "92.0", "%", ")", "compared", "to", "the", "episomal", "reprogramming", "method", "(", "38.5", "%", ")", "regardless", "of", "source", "material", "(", "Figure", "3A", "and", "Table", "3", ")", "." ] } ]
PMC11697189
The relative expression levels of these genes were calculated by the 2 method.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "expression", "levels", "of", "these", "genes", "were", "calculated", "by", "the", "2", "method", "." ] } ]
PMC9429973
Seventeen centers responded, accounting for 803 AYA patients (489 males, 315 females) treated between 2005 and 2020.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventeen", "centers", "responded", ",", "accounting", "for", "803", "AYA", "patients", "(", "489", "males", ",", "315", "females", ")", "treated", "between", "2005", "and", "2020", "." ] } ]
PMC11411131
Similar to selenium depletion, under MeHg exposure, the NMD complex recognizes the UGA codon of Sec as a PTC, resulting in a reduction of GPx1 mRNA (Fig. 1A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "selenium", "depletion", ",", "under", "MeHg", "exposure", ",", "the", "NMD", "complex", "recognizes", "the", "UGA", "codon", "of", "Sec", "as", "a", "PTC", ",", "resulting", "in", "a", "reduction", "of", "GPx1", "mRNA", "(", "Fig.", "1A", ")", "." ] } ]
PMC9429973
These findings support Mel dosing based on body surface area when combined with Flu as RIC regimen used for allo-HCT.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "support", "Mel", "dosing", "based", "on", "body", "surface", "area", "when", "combined", "with", "Flu", "as", "RIC", "regimen", "used", "for", "allo-HCT", "." ] } ]
PMC3931643
4EBP1 expression was induced with 1 µg/ml Doxycycline for 16 hrs followed by a 4 hr treatment with 100 nM MLN0128.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4EBP1", "expression", "was", "induced", "with", "1", "µg/ml", "Doxycycline", "for", "16", "hrs", "followed", "by", "a", "4", "hr", "treatment", "with", "100", "nM", "MLN0128", "." ] } ]
PMC11462673
Meanwhile, the expression of the apoptosis protein PARP exhibited a progressive rise according to the dose applied (Fig. 7B and Fig. S11B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "the", "expression", "of", "the", "apoptosis", "protein", "PARP", "exhibited", "a", "progressive", "rise", "according", "to", "the", "dose", "applied", "(", "Fig.", "7B", "and", "Fig.", "S11B", ")", "." ] } ]
PMC11634027
Extensive studies of the Fat intracellular domain (ICD) have provided insights into how it mediates downstream signal transduction and supported its classification as a signal-transducing receptor (Fulford et al., 2023; Matakatsu and Blair, 2012; Pan et al., 2013; Zhao et al., 2013).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extensive", "studies", "of", "the", "Fat", "intracellular", "domain", "(", "ICD", ")", "have", "provided", "insights", "into", "how", "it", "mediates", "downstream", "signal", "transduction", "and", "supported", "its", "classification", "as", "a", "signal-transducing", "receptor", "(", "Fulford", "et", "al.", ",", "2023", ";", "Matakatsu", "and", "Blair", ",", "2012", ";", "Pan", "et", "al.", ",", "2013", ";", "Zhao", "et", "al.", ",", "2013", ")", "." ] } ]
PMC6684588
Through a similar mechanism, BMPs and other GDFs trigger activation of Smad1/5/8 signaling, which promotes protein synthesis, myofiber hypertrophy, and increased muscle mass.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "a", "similar", "mechanism", ",", "BMPs", "and", "other", "GDFs", "trigger", "activation", "of", "Smad1/5/8", "signaling", ",", "which", "promotes", "protein", "synthesis", ",", "myofiber", "hypertrophy", ",", "and", "increased", "muscle", "mass", "." ] } ]
PMC7351993
For example, for applications that involve smaller cells (<3 µm) such as bacteria, other focusing techniques such as 3D hydrodynamic focusing with a narrower microchannel (instead of 2D hydrodynamic focusing used in this work), inertial focusing, deterministic lateral displacement, hydrophoretic focusing, and viscoelastic focusing can be implemented to focus them more tightly.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "for", "applications", "that", "involve", "smaller", "cells", "(", "<3", "µm", ")", "such", "as", "bacteria", ",", "other", "focusing", "techniques", "such", "as", "3D", "hydrodynamic", "focusing", "with", "a", "narrower", "microchannel", "(", "instead", "of", "2D", "hydrodynamic", "focusing", "used", "in", "this", "work", ")", ",", "inertial", "focusing", ",", "deterministic", "lateral", "displacement", ",", "hydrophoretic", "focusing", ",", "and", "viscoelastic", "focusing", "can", "be", "implemented", "to", "focus", "them", "more", "tightly", "." ] } ]
PMC11541409
Currently, only SCF has been reported as a targeting domain for CAR T therapy in GISTs, showing efficacy in animal models .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "only", "SCF", "has", "been", "reported", "as", "a", "targeting", "domain", "for", "CAR", "T", "therapy", "in", "GISTs", ",", "showing", "efficacy", "in", "animal", "models", "." ] } ]
PMC11737091
Following a 24-h period of cultivation, the invading cells on the bottom were fixed with 4% paraformaldehyde and then stained with 0.1% crystal violet (Beyotime, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "a", "24-h", "period", "of", "cultivation", ",", "the", "invading", "cells", "on", "the", "bottom", "were", "fixed", "with", "4", "%", "paraformaldehyde", "and", "then", "stained", "with", "0.1", "%", "crystal", "violet", "(", "Beyotime", ",", "China", ")", "." ] } ]
PMC11640247
To quantify GFP-positive cell distribution, coronal sections of the labeled cortex were divided into three bins, with labeled cells counted across a minimum of three sections per brain.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "quantify", "GFP-positive", "cell", "distribution", ",", "coronal", "sections", "of", "the", "labeled", "cortex", "were", "divided", "into", "three", "bins", ",", "with", "labeled", "cells", "counted", "across", "a", "minimum", "of", "three", "sections", "per", "brain", "." ] } ]
PMC11768281
The titles and abstracts of identified studies were screened to exclude irrelevant articles, followed by a full-text review conducted and independently (blinded) by two reviewers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "titles", "and", "abstracts", "of", "identified", "studies", "were", "screened", "to", "exclude", "irrelevant", "articles", ",", "followed", "by", "a", "full-text", "review", "conducted", "and", "independently", "(", "blinded", ")", "by", "two", "reviewers", "." ] } ]
PMC10607604
We also demonstrated that PTPN13 mRNA expression is an independent prognostic marker of increased overall survival in breast cancer .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "demonstrated", "that", "PTPN13", "mRNA", "expression", "is", "an", "independent", "prognostic", "marker", "of", "increased", "overall", "survival", "in", "breast", "cancer", "." ] } ]
PMC11794568
Transwell invasion assay revealed that rotenone reversed the invasive ability of melanoma cells promoted by silencing CRIP1 (Fig. 7C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transwell", "invasion", "assay", "revealed", "that", "rotenone", "reversed", "the", "invasive", "ability", "of", "melanoma", "cells", "promoted", "by", "silencing", "CRIP1", "(", "Fig.", "7C", ")", "." ] } ]
PMC9479186
There is an urgent need to discover newer therapeutic targets to provide new therapeutic strategies for liver cancer treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "an", "urgent", "need", "to", "discover", "newer", "therapeutic", "targets", "to", "provide", "new", "therapeutic", "strategies", "for", "liver", "cancer", "treatment", "." ] } ]
PMC5311252
Supernatants containing proteins were collected into new vials.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supernatants", "containing", "proteins", "were", "collected", "into", "new", "vials", "." ] } ]
PMC8358176
Streptomycin-penicillin and the Jurkat cell line were obtained from Gibco (Gaithersburg, MD, USA) and the National Center for Genetic and Biological Resources of Iran (Tehran, Iran), respectively.
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Streptomycin-penicillin", "and", "the", "Jurkat", "cell", "line", "were", "obtained", "from", "Gibco", "(", "Gaithersburg", ",", "MD", ",", "USA", ")", "and", "the", "National", "Center", "for", "Genetic", "and", "Biological", "Resources", "of", "Iran", "(", "Tehran", ",", "Iran", ")", ",", "respectively", "." ] } ]
PMC9429973
Methods: The registry of the Argentinian Group of Acute Leukemia (GALA) from the Argentine Society of Hematology (SAH) includes data from 20 centers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "registry", "of", "the", "Argentinian", "Group", "of", "Acute", "Leukemia", "(", "GALA", ")", "from", "the", "Argentine", "Society", "of", "Hematology", "(", "SAH", ")", "includes", "data", "from", "20", "centers", "." ] } ]
PMC11555465
These results indicated that the culture supernatant of T. gondii tachyzoites could be a promising therapeutic agent for the treatment of bladder cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicated", "that", "the", "culture", "supernatant", "of", "T.", "gondii", "tachyzoites", "could", "be", "a", "promising", "therapeutic", "agent", "for", "the", "treatment", "of", "bladder", "cancer", "." ] } ]
PMC9587298
The same effect was not observed for Caco-2 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "same", "effect", "was", "not", "observed", "for", "Caco-2", "cells", "." ] } ]
PMC11052306
In view of the large difference observed between copper and gold, the question of the quantity of gold necessary to obtain the same effect arose.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "view", "of", "the", "large", "difference", "observed", "between", "copper", "and", "gold", ",", "the", "question", "of", "the", "quantity", "of", "gold", "necessary", "to", "obtain", "the", "same", "effect", "arose", "." ] } ]
PMC11402217
1 × 10ˆ6 143B cells were plated in 6-well plates with ibidi Culture-Inserts (ibidi, DE) and cultivated in serum-free medium with 0.5 μM XD23 for 24 h. Sequential images of the scratch were taken every 6 h. For the Transwell migration assay, a 6.5 mm Transwell with an 8.0 μm PET insert (Corning, 3464#, US) was placed in a 24-well plate and coated with a Matrigel Matrix mixture.
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "×", "10ˆ6", "143B", "cells", "were", "plated", "in", "6-well", "plates", "with", "ibidi", "Culture-Inserts", "(", "ibidi", ",", "DE", ")", "and", "cultivated", "in", "serum-free", "medium", "with", "0.5", "μM", "XD23", "for", "24", "h.", "Sequential", "images", "of", "the", "scratch", "were", "taken", "every", "6", "h.", "For", "the", "Transwell", "migration", "assay", ",", "a", "6.5", "mm", "Transwell", "with", "an", "8.0", "μm", "PET", "insert", "(", "Corning", ",", "3464", "#", ",", "US", ")", "was", "placed", "in", "a", "24-well", "plate", "and", "coated", "with", "a", "Matrigel", "Matrix", "mixture", "." ] } ]
PMC7685376
Kaplan-Meier survival curves for HCC patients with low (n = 182) or high (n = 182) MCM expressions (MCM2, MCM3, and MCM4) which extracted from GEPIA database. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "survival", "curves", "for", "HCC", "patients", "with", "low", "(", "n", "=", "182", ")", "or", "high", "(", "n", "=", "182", ")", "MCM", "expressions", "(", "MCM2", ",", "MCM3", ",", "and", "MCM4", ")", "which", "extracted", "from", "GEPIA", "database", ".", "(" ] } ]
PMC11746942
Fig. 1E, G).
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1E", ",", "G", ")", "." ] } ]
PMC11525028
Red dots indicate upregulated genes (fold change >1.25, adjusted p value <0.05), blue dots indicate downregulated genes (fold change <0.75, adjusted p value <0.05).(B) Gene profiling showing the ac4C modification distribution of NAT10-KO cells compared to that of control cells.(C) Volcano plot showing the ac4C peak of NAT10-KO compared to control cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "dots", "indicate", "upregulated", "genes", "(", "fold", "change", ">", "1.25", ",", "adjusted", "p", "value", "<", "0.05", ")", ",", "blue", "dots", "indicate", "downregulated", "genes", "(", "fold", "change", "<", "0.75", ",", "adjusted", "p", "value", "<", "0.05).(B", ")", "Gene", "profiling", "showing", "the", "ac4C", "modification", "distribution", "of", "NAT10-KO", "cells", "compared", "to", "that", "of", "control", "cells.(C", ")", "Volcano", "plot", "showing", "the", "ac4C", "peak", "of", "NAT10-KO", "compared", "to", "control", "cells", "." ] } ]
PMC10759659
1 package was used for all analyses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "package", "was", "used", "for", "all", "analyses", "." ] } ]
PMC11682224
The second most prevalent skin cancer, after basal cell carcinoma, is cutaneous squamous cell carcinoma (SCC).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second", "most", "prevalent", "skin", "cancer", ",", "after", "basal", "cell", "carcinoma", ",", "is", "cutaneous", "squamous", "cell", "carcinoma", "(", "SCC", ")", "." ] } ]
PMC11509224
Eight diterpenoids, kalihinols M–T (9–16, Figure 3), were isolated from the South China Sea sponge Acanthella cavernosa .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "diterpenoids", ",", "kalihinols", "M", "–", "T", "(", "9–16", ",", "Figure", "3", ")", ",", "were", "isolated", "from", "the", "South", "China", "Sea", "sponge", "Acanthella", "cavernosa", "." ] } ]
PMC11767725
Adipokines, such as leptin and resistin, secreted by hypertrophic adipose tissue in obesity, enhance Th1 and Th17 polarization, contributing to pro-inflammatory cytokine production that disrupts microbial homeostasis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adipokines", ",", "such", "as", "leptin", "and", "resistin", ",", "secreted", "by", "hypertrophic", "adipose", "tissue", "in", "obesity", ",", "enhance", "Th1", "and", "Th17", "polarization", ",", "contributing", "to", "pro-inflammatory", "cytokine", "production", "that", "disrupts", "microbial", "homeostasis", "." ] } ]
PMC9429973
These results may lead to developing new therapeutic strategies to target MYC in clinical practice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "may", "lead", "to", "developing", "new", "therapeutic", "strategies", "to", "target", "MYC", "in", "clinical", "practice", "." ] } ]
PMC10729469
C Changes in the expression of the disease-associated genes for astrocytes (GFAP) and microglia (Clec7A, Itgax, and TREM2) in cortical tissue by qPCR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Changes", "in", "the", "expression", "of", "the", "disease-associated", "genes", "for", "astrocytes", "(", "GFAP", ")", "and", "microglia", "(", "Clec7A", ",", "Itgax", ",", "and", "TREM2", ")", "in", "cortical", "tissue", "by", "qPCR", "." ] } ]
PMC10993311
A growing number of studies using the Illumina Infinium Human MethylationEPIC BeadChip have generated data on pregnancy and fetal programming (Sharp et al., 2015; Hjort et al., 2018; Mas-Parés et al., 2023).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "growing", "number", "of", "studies", "using", "the", "Illumina", "Infinium", "Human", "MethylationEPIC", "BeadChip", "have", "generated", "data", "on", "pregnancy", "and", "fetal", "programming", "(", "Sharp", "et", "al.", ",", "2015", ";", "Hjort", "et", "al.", ",", "2018", ";", "Mas-Parés", "et", "al.", ",", "2023", ")", "." ] } ]
PMC11789597
The expression level of mRNA was quantified by qRT‐PCR using ChamQ universal SYBR qPCR Master Mix regent (Vazyme) and specific primers (Table S1, Supporting Information).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "level", "of", "mRNA", "was", "quantified", "by", "qRT‐PCR", "using", "ChamQ", "universal", "SYBR", "qPCR", "Master", "Mix", "regent", "(", "Vazyme", ")", "and", "specific", "primers", "(", "Table", "S1", ",", "Supporting", "Information", ")", "." ] } ]
PMC11723947
S2f-o).
[ { "tags": [ "O", "O", "O" ], "tokens": [ "S2f-o", ")", "." ] } ]
PMC10114490
A Representative fluorescence images of cells immunostained with antibodies against human albumin and α1-antitrypsin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Representative", "fluorescence", "images", "of", "cells", "immunostained", "with", "antibodies", "against", "human", "albumin", "and", "α1-antitrypsin", "." ] } ]
PMC9429973
Aims: To evaluate real world results of axicabtagene ciloleucel (axi-cel) for R/R LBCL on a population level, including reasons for ineligibility, efficacy, toxicity and (in a subset of patients) HR-QoL. Methods: For this prospective multicenter cohort study, all adult patients referred to the tumorboard for treatment of R/R LBCL with axi-cel were included from May 1 2020 – October 19 2021.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "real", "world", "results", "of", "axicabtagene", "ciloleucel", "(", "axi-cel", ")", "for", "R/R", "LBCL", "on", "a", "population", "level", ",", "including", "reasons", "for", "ineligibility", ",", "efficacy", ",", "toxicity", "and", "(", "in", "a", "subset", "of", "patients", ")", "HR-QoL.", "Methods", ":", "For", "this", "prospective", "multicenter", "cohort", "study", ",", "all", "adult", "patients", "referred", "to", "the", "tumorboard", "for", "treatment", "of", "R/R", "LBCL", "with", "axi-cel", "were", "included", "from", "May", "1", "2020", "–", "October", "19", "2021", "." ] } ]
PMC11665584
As observed with the keratinocyte subpopulations, the other cell type subpopulations were proportionally shifted toward an oral like state upon cutaneous expression of PITX1, demonstrating a potent keratinocyte-derived paracrine effect on tissue composition and organization.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "observed", "with", "the", "keratinocyte", "subpopulations", ",", "the", "other", "cell", "type", "subpopulations", "were", "proportionally", "shifted", "toward", "an", "oral", "like", "state", "upon", "cutaneous", "expression", "of", "PITX1", ",", "demonstrating", "a", "potent", "keratinocyte-derived", "paracrine", "effect", "on", "tissue", "composition", "and", "organization", "." ] } ]
PMC11699178
In the present analysis, we successfully identified the key gene HIF-1α, which influences the progression of breast cancer in response to GEM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "analysis", ",", "we", "successfully", "identified", "the", "key", "gene", "HIF-1α", ",", "which", "influences", "the", "progression", "of", "breast", "cancer", "in", "response", "to", "GEM", "." ] } ]
PMC11742431
Scale bar, 300 µm.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "300", "µm", "." ] } ]
PMC9436459
As shown in Scheme 4, (S)-VAPOL effectively catalyzed the cycloaddition with high exo selectivity (exo/endo = 13:1) and ee value (97%), while the chiral ligand (R)-6,6′-dibromo-VANOL gave a good endo-selectivity (exo/endo = 3.5:1) and satisfying ee value (96%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Scheme", "4", ",", "(S)-VAPOL", "effectively", "catalyzed", "the", "cycloaddition", "with", "high", "exo", "selectivity", "(", "exo/endo", "=", "13:1", ")", "and", "ee", "value", "(", "97", "%", ")", ",", "while", "the", "chiral", "ligand", "(R)-6,6′-dibromo-VANOL", "gave", "a", "good", "endo-selectivity", "(", "exo/endo", "=", "3.5:1", ")", "and", "satisfying", "ee", "value", "(", "96", "%", ")", "." ] } ]
PMC11122631
The synthetic accessibility scores of all nine compounds were located in a similar range (4.58 to 5.41; Table S20), which might be at the moderately difficult level for the synthetic accessibility of the compounds.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "synthetic", "accessibility", "scores", "of", "all", "nine", "compounds", "were", "located", "in", "a", "similar", "range", "(", "4.58", "to", "5.41", ";", "Table", "S20", ")", ",", "which", "might", "be", "at", "the", "moderately", "difficult", "level", "for", "the", "synthetic", "accessibility", "of", "the", "compounds", "." ] } ]
PMC9712534
The mobile fractions were estimated to be 0.86 ± 0.05 (DMSO) and 0.86 ± 0.04 (ICRF).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mobile", "fractions", "were", "estimated", "to", "be", "0.86", "±", "0.05", "(", "DMSO", ")", "and", "0.86", "±", "0.04", "(", "ICRF", ")", "." ] } ]
PMC11769516
ZEA affects neurons in the central nervous system by crossing the BBB .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZEA", "affects", "neurons", "in", "the", "central", "nervous", "system", "by", "crossing", "the", "BBB", "." ] } ]
PMC11116779
The samples were embedded in Epon 812.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "embedded", "in", "Epon", "812", "." ] } ]
PMC11775197
With the deepening of research, it has been revealed that PPARs, as a transcription factor, are inextricably linked to CRC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "deepening", "of", "research", ",", "it", "has", "been", "revealed", "that", "PPARs", ",", "as", "a", "transcription", "factor", ",", "are", "inextricably", "linked", "to", "CRC", "." ] } ]
PMC11615828
Light‐induced vesicle clustering has also been utilized to block the function of Rab vesicles and synaptic vesicles on the timescale of minutes. , ,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Light‐induced", "vesicle", "clustering", "has", "also", "been", "utilized", "to", "block", "the", "function", "of", "Rab", "vesicles", "and", "synaptic", "vesicles", "on", "the", "timescale", "of", "minutes", ".", ",", "," ] } ]
PMC9966931
Cinnamomun zeylanicum Blume) and thyme (Thymus vulgaris L.) have been used by humans since ancient times due to their pesticidal, antimicrobial, antioxidant, and medicinal properties .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cinnamomun", "zeylanicum", "Blume", ")", "and", "thyme", "(", "Thymus", "vulgaris", "L.", ")", "have", "been", "used", "by", "humans", "since", "ancient", "times", "due", "to", "their", "pesticidal", ",", "antimicrobial", ",", "antioxidant", ",", "and", "medicinal", "properties", "." ] } ]
PMC11122631
Fraction D (2.7 g) eluted with hexanes/ethyl acetate/methanol (100/10/1 to 0/0/1) was further separated by silica gel CC to obtain six subfractions (D1–D6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fraction", "D", "(", "2.7", "g", ")", "eluted", "with", "hexanes/ethyl", "acetate/methanol", "(", "100/10/1", "to", "0/0/1", ")", "was", "further", "separated", "by", "silica", "gel", "CC", "to", "obtain", "six", "subfractions", "(", "D1–D6", ")", "." ] } ]
PMC8389560
The expression levels of the other genes studied in the work, key participants in various pathways of apoptosis, practically did not differ in these samples compared to the control (intact cells).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "levels", "of", "the", "other", "genes", "studied", "in", "the", "work", ",", "key", "participants", "in", "various", "pathways", "of", "apoptosis", ",", "practically", "did", "not", "differ", "in", "these", "samples", "compared", "to", "the", "control", "(", "intact", "cells", ")", "." ] } ]
PMC7185206
Similar analyses across the TCGA dataset are reported in Table 1, Supplemental Figure 1, and Supplemental Tables 1–2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "analyses", "across", "the", "TCGA", "dataset", "are", "reported", "in", "Table", "1", ",", "Supplemental", "Figure", "1", ",", "and", "Supplemental", "Tables", "1–2", "." ] } ]