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PMC11679326
In addition, glioma cells expressing ST6GAL1 did not initiate tumors in vivo, suggesting that the abundance of terminal α2,6-linked sialic acids is a negative regulator of glioma cell invasion .
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PMC11787355
In addition, a previous study revealed that tumor-associated macrophages secrete PTN, which is tumor-promoting and positively associated with PTPRZ1 expression and stemness of glioblastoma cells.
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PMC11585565
The anti-FLAG clone M2 (Sigma-Aldrich, Cat#F1804) or anti-GAPDH (Abcam) primary antibody was incubated with the membrane at 4ºC overnight.
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PMC10976516
Other encouraging prospects arise for early-stage, non-metastasized lung cancer through local application of OVs in either the pleural cavity or supported by advanced bronchoscopic techniques in the case of parenchymal lung tumor lesions.
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PMC7154001
This information is essential for cancer chemotherapy with a narrow therapeutic window, particularly in individuals with increased or decreased drug-metabolizing enzyme activities influenced by genetic and nongenetic factors.
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PMC10820104
The specific optical rotation of compound 1 is negative, which is consistent with the negative values reported for other known neoechinulin A series of indole diketopiperazine alkaloids with 12S and 22S configurations, proposing that the new compound 1 shares the same absolute configuration as the known derivatives .
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PMC9429973
The real impact of COVID-19 on the life expectancy of patients with different subtypes of lymphoma and targeted treatment is still unknown.
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PMC11599565
However, this was previously observed in the context of colorectal carcinomas and associated with high metastatic potential.
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PMC11612626
E.G7-Ova cells have been genetically modified to constitutively synthesize Ova, which upon proteasomal degradation generates the antigenic peptide SIINFEKL OVA (257–264), which is presented by H2Kb (36).
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PMC9429973
Most patients were in an advance stage by Durie Salmon at diagnosis (DS IIIA or IIIB: n=207, 56.6%), and had high risk ISS (ISS 3: n=113, 46.7%; 124 unknown).
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PMC11271800
TAM-derived IL-6 increases the expression of CC ligand 2 (CCL2) and EIF4A3 in tumor cells, which results in increased proliferation and invasion of breast cancer cells; TAMs also promote HCC cell resistance to sorafenib via chemokine CXC ligand (CXCL) 1 and CXCL2.
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PMC9822769
In cisplatin-based Pt(IV) prodrugs, we prefer the terms symmetric when the two axial ligands are identical and unsymmetric when the two axial ligands are different, rather than asymmetric or nonsymmetric which implies that all symmetry elements have been lost.
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PMC6312945
Lipofectamine 2000 transfection reagent was purchased from Shanghai Hengfei Biotechnology Co., Ltd., Shanghai, China (cat no. 11668019).
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PMC11680049
When cultivating primary explants (shoot segments) vertically in light, callus formation of yellow-green color was observed in the zone of contact between the shoot and the nutrient medium by days 17 to 20 (Figure 5a,b).
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PMC6643347
Of note, the concentrations required to achieve 50% suppression of the infection induced by the sensitive strain were almost identical in the continuous and primary cells ( < 1 μg/ml).
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PMC9351137
At least 200 telophases were scored in two independent experiments for both treated cells and control HeLa cells.
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PMC11422497
Current research indicates that miR-494-3p primarily participates as a tumor suppressor gene in the occurrence, development, and drug resistance processes of cancer.
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PMC10530622
In the other sense, glyoxylate is converted into glycolate by glyoxylate reductase, an enzyme that has also named GRHPR .
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PMC11361748
Strategy for single and double topical TPA Tx, 24 h apart, and skin tissue sampling.
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PMC11092382
Sophocarpine effectively protected kidneys against lupus nephritis in MRL/lpr mice.
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PMC11755519
The results showed that all exosomes induced complement activation.
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PMC10055960
The results reported in this work suggest that structural modifications of the dendritic molecules are required to improve their solubility in the biological medium.
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PMC10577955
The percentage of viability was calculated by using the following formula: [12pt] $$\%\;\;\;\:=\:\;\;/\;\;\;\;100$$%Ofcellviability=ODofSample/ODofControl×100 OD: optical density.
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PMC7351993
e Fluorescence images of sorted and unsorted particles in the collection and waste tubes, respectively (n = 2).
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PMC11365427
Moreover, 4-PBA was found to inhibit the expression of ERS-associated ATF3 and CHOP, as well as reduce the expression of apoptotic proteins under phenylalanine deprivation (Fig. 7H and Fig. S9F).Figure 7ATF3 is a key target in phenylalanine deprivation-induced ERS and apoptosis. (
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PMC11397654
However, it has been unclear so far whether they display significant levels of activity against already existing cancer cells.
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PMC11733919
We have previously demonstrated that similar MNPs (in shape and size and coated with the same polymer, PMAO) are able to enter the cell through endocytosis and that the MNPs can slowly degrade, both in vitro and in vivo.
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PMC9516447
Here, we report that GRP78 knockdown reduces KRAS protein level in a panel of human LUAD, PDAC and colorectal cancer cell lines bearing various mutant KRAS alleles, and the regulation is at the post-transcriptional level.
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PMC5330095
Chronic cases of HBV as well as HCV are among the leading causes of liver cirrhosis and hepatocellular carcinoma (HCC) in the world.
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PMC11045125
Thus, as occurs in human BL tumors, the ΔEBNA2 + Myc lymphomas have a more stringent form of EBV latency (EBNA1-pos, LMP1-neg, EBNA2-neg) in comparison to the lymphomas infected with ΔEBNA2 alone, which have high level LMP1 expression.
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PMC10852540
One of these new agents is RA, a natural antioxidant.
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PMC10854447
Docking simulations highlighted the output of including 1,2,4-oxadiazole scaffold to improve the binding of the compounds within the active sites of EGFR and VEGFR-2.
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PMC11413393
Data presented at day 5 for 786-0, Day 7 for RCC243, day 8 for RCC407, day 12 for RCC22 and day 14 for RCC323 (determined based on the time at which control-treated cells reached confluence).
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PMC9429973
Nevertheless, relapse incidence remains high, even in patients transplanted in CR1, highlighting the necessity of maintenance therapy with FLT3 inhibitors.
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PMC11742864
The involvement of lipid rafts on phospholipid membranes modulates T cell activation and monocyte functions.
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PMC11588085
Ovarian cancer SKOV3ip cells are known to be highly invasive (55) and XIST KD did not significantly alter cell invasion or migration in SKOV3-KRAB; however, OVCAR3-KRAB cells with XIST KD exhibited increased invasion and migration (Fig. 4 B and C).
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PMC11720107
Therefore, in the last part of our work, we examined the mRNA and protein expression of antioxidant enzymes such as SOD1 and CAT, whose expression is controlled by PPARγ.
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PMC11085211
The nuclear dye (in the graphs indicated as “Nucleated Cells” on the y-axis) differentiates nucleated cells from cellular debris, while the viability dye brightly stains dying cells (in the graphs indicated as “Viability” on the x-axis).
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PMC11612315
c Mean normalized currents of sequential CAP-induced currents (mean ± S.E.M.).
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PMC8524093
Structural proteins are required for many viral processes, including virus assembly, receptor binding, and membrane fusion (Jose et al., 2009).
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PMC11700523
MR activation is triggered by aldosterone or cortisol as a ligand; however, ligand-independent MR activation mechanisms such as increased transcription and sensitivity, stabilization, and other factors are also considered [13,17-19].
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PMC11739484
The miRNet (https://www.mirnet.ca/) database is a valuable resource for investigating microRNA (miRNA) interactions and their regulatory networks.
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PMC9874064
Yajuan Gao: Data curation.
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PMC11733919
As an early response, SOD1 levels were also increased in 17-DMAG-treated senescent skin cancer cells, but this was not observed after 24 h treatment (Figure 5d).
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PMC8633974
To account for the low abundance of HIV genome in the genomic DNA content, nested PCR was performed with HIV specific primers as previously described in both treated and untreated group.
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PMC11335267
p < 0.05; **p < 0.01; ***p < 0.001, Student’s t test (A, E, G and I) or two-way ANOVA followed by Bonferroni transformation (H, J and K) We did not find significant differences in the expression of genes regulating glucose transport and metabolism or mitochondrial function in the gastrocnemius muscle (Supplementary Fig. 6), indicating that an intrinsic metabolic dysfunction is unlikely to be responsible for the muscle phenotype in Alx3-deficient animals.
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PMC11381192
High CSI was significantly correlated with cell division pathways and poor clinical prognosis.
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PMC7022782
Ultrapure bi-distilled water was obtained by a MilliQ R4 system, Millipore (Milan, Italy).
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PMC10747160
Li Wu and Vineet N. KewalRamani);Raji DC-SIGN+ cells (Homo sapiens, Epstein–Barr Virus (EBV)-positive Burkitt lymphoma line originally obtained from the American Type Culture Collection (ATCC); obtained through the NIH HIV Reagent Program, Division of AIDS, NIAID, NIH: Raji cells, ARP-9945; contributed by Drs.
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PMC9429973
Key eligibility criteria include 2 two prior lines of therapy (1 prior for WM); measurable disease; and an Eastern Cooperative Oncology Group performance status of 0 or 1.
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PMC11585565
For p.(Thr495Ile), its protein level was significantly reduced to 36.0 ± 9.3% after 12 h of treatment.
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PMC11766350
Directional cloning with SanDI restriction sites was used to increase the copy number of shRNA cassettes in the plasmid, with a view to increasing shRNA expression.
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PMC9429973
Results: The patients are between 33 and 92 years old, the average age is 65, with a female predominance, the sex ratio is 0.82.
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PMC11670954
These findings align with those of previous studies , suggesting that LPS induces dysfunction of the intestinal epithelial barrier.
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PMC10812665
Most other toxicants led to average increases of about 400% (Figure 8D).
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PMC11401350
100-fold concentrated vector preparations were stored at -80 °C.
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PMC4005030
Thus PCA could be highly useful in diabetic complications via its triglyceride-lowering, anticoagulatory, antioxidative, and anti-inflammatory effects.
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PMC10094712
A marked decrease (approximately 20–25%) in the viability of HEK 293 cells was observed only after they were treated with a high concentration (200 μg) of the protein under study.
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PMC9429973
Results: First, we assessed cell intrinsic effects of these Ddx41 alleles, in noncompetitive transplantation experiments.
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PMC11739504
Additionally, acetyl transferase inactivation of Kat2b using garcinol was confirmed to attenuate ciliary recruitment of IFT52 (Fig. 3h).
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PMC11407042
•A high concentration of serum may lead to a high background absorbance.
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PMC5035325
3LL-D122-metastasis model: C57BL/6 mice were injected into lateral tail veins (i.v.)
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PMC5854676
The loss of cell viability can be expressed using a second order polynomial model, as shown in Eq. (3).
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PMC11551844
For AuNPs-JDE, the cytotoxicity reduced on A172 and HaCaT cells but increased on TERA1, HeLa and HepG2 cells in comparison with JDE.
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PMC9164404
Transcriptomics and metabolomics study on the mechanism of Abplatin revealed Abplatin significantly disturbed the purine metabolism pathway.
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PMC11777207
Consistent with the established genotype of B7 mice, there was no surface-associated CD80 detected and, interestingly, lower levels of PD-L1 by gMFI on FITC cDC1s and cDC2s in B7 mice compared to WT (fig. S2, J to O).
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PMC3019555
Bar graph showing the percentage of HIF-1α mRNA localized to P-bodies after the indicated drug treatments. (
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PMC9164404
Moreover, it was reported that the overexpression of ABAT gene could significantly reduce cell proliferation and migration, and impair the production of lactic acid .
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PMC11772585
All experiments involving human tissues were carried out in compliance with the Helsinki Declaration and were approved by the Institutional Review Board of Shanghai Outdo Biotech Co., Ltd. (approval number SHYJS-CP-2001009).Table 1Basic information for healthy people and cSCC patients.
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PMC7351993
The cavity length of the Yb fiber laser is controlled by an intracavity electro-optic modulator (NIR-MPX-LN-0.1-P-P, Photline) and a piezoelectric transducer (P-611.3 S, Physik Instrumente) on which an end mirror is fixed to achieve the precise synchronization between the pump and Stokes pulse trains.
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PMC6133382
Daily counts were taken, and cell cultures were expanded to maintain a density of 0.3 × 10−1.0 × 10 cells/mL. Fluorescein-labeled GNA, from the snowdrop pea (Vector Laboratories, Burlingame, CA, US), was used to detect the cell surface expression of Man5 glycoforms.
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PMC10253553
The ChemiDoc MP Imaging System (Bio-Rad) was used to quantify band density and acquire western blot images.
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PMC8751435
Breakdown of DNA stems from CME‐induced lipid peroxidation and its oxidative impairment on nucleotide (Bao et al., 2018).
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PMC8010066
Therefore, this study aims to investigate the resistance to carbapenems and tobramycin and the pathogenicity of P. aeruginosa co-cultured with S. aureus in a cell-culture model.
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PMC11721587
Of note, the SUMO epitope was not detected in the SDS-resistant Fu dimers but was detected in the Fu monomers derived from the dimers after extensive incubation in 2× SDS loading buffer (fig. S3B), suggesting that the mature Fu was SUMO conjugated, but the SUMO epitope was not exposed. (
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PMC11711935
However, the role of dermal fibroblasts, another critical skin cell type, has not received sufficient attention despite emerging evidence of their involvement in pigmentation regulation.
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PMC11549062
p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, and p > 0.05.
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PMC11049548
To our knowledge, human-like media have never been employed in metabolomic studies on these cell types, and there is no evidence that primary ovarian cancer cells can be established in these media.
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PMC10810426
Whether this cytoplasmic interaction is the result of MLV causing NUP mislocalization is not clear.
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PMC5308810
For statistical comparisons, Graph Pad Prism 7.0 software was used to determine p-values using Student’s t-test and two-way ANOVA.
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PMC11548041
Cy5 intensity on aptamer-functionalized MNVs increased in a dose-dependent manner proportional to the amount of aptamer used for functionalization (Figure 4, white values in Cy5 channel images).
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PMC9927933
We next determined the effect of UBE2C inactivation on overall survival of mice upon Kras activation by comparison of the survival probability between 2 groups.
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PMC10329237
Furthermore, the combination treatment significantly improved cellular anti-oxidant markers compared with the BLM-treated group.
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PMC11371627
We showed that the XK deletion in our patient results in diminished expression of the Kell blood group antigen Cellano (k), however, real-time PCR revealed no restriction of KEL gene expression on RNA level.
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PMC9429973
The complete metabolic response observed persists currently more than a year following treatment initiation.
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PMC11248911
Concerning its structure, APN is composed of 967 amino acids; it retains three hydrophobic pockets that bind the substrates and surrounds one catalytic zinc ion.
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PMC9429973
Methods: Platelets were purified from peripheral blood samples obtained from healthy individuals.
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PMC9429973
Aims: Recent studies on MDS BM ecosystem suggest a possible symbiotic relationship between cancer, immune and stromal cells.
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PMC7189327
Moreover, functional analysis revealed that hedgehog signaling pathways were possibly related to classical BCC development .
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PMC5916734
The copy number of expression cassette integrated into the genome was calculated using a calibration curve plotted for serial dilutions of plasmid p1.1-F9.
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PMC10507284
Statistical tests: Log‐rank test. (
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PMC11093197
Immunoblotting of indicated proteins in Scr, shRB1#1, and shRB1#2 MCF10A cells treated with vehicle or proteasomal inhibitor MG‐132.
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PMC11741906
Previous studies have shown that the MAPK signaling pathway is activated in diverse types of tumors, including ovarian cancer .
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PMC8973725
In this study, we used bioinformatics analysis and in vitro experiments to investigate the expression of ZNF677 in ccRCC tissues and the malignant biological behavior of ZNF677 in 786–0 cells.
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PMC11218145
The animals were housed in pathogen-free environment, and all experiments were performed in accordance to the National Regulation on Animal Research Resources and approved by the Review Board of the IRCCS Policlinico San Martino, Genoa, Italy, and Italian Ministry of Health (n° 462/202PR, Dl.vo 4/04/2014 n 26).
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PMC10237474
To circumvent this problem, human cell lines such as HEK293 can be used to produce therapeutics with native PTMs .
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PMC11802855
In CCLE database, CXCL7 expression was found to be low in the NCI-H929 cell line, moderate in the RPMI 8226 cell line, and high in the U266 cell line (Fig. 4A).
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PMC11228511
Boxed regions are shown at higher magnification to the Right. (
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PMC5916734
In the resulting population of stably transfected cells containing three gene cassettes for the expression of factor IX and two auxiliary enzymes, the specific procoagulant activity of FIX in the culture medium was 27% of the reference value; the percentage of secreted FIX molecules with the uncleaved propeptide determined by ELISA was only 3.1% (Fig. 2B).
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PMC11790599
Quantitative FITC-dextran (70 kDa) uptake by SK-BR-3_LR600 determined by flow cytometry after treated with TSL (6.32 μM) and lapatinib (600 nM) for 24 h. A working model for TSL-induced methuosis suggested by the present studies is shown in Figure 8.
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