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PMC11756514
Additionally, MBL interacts more strongly with the JE2ΔtarM mutant than the WT.
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PMC9429973
During the randomized treatment period, patients were assigned (2:1 ratio) to receive either SC ravulizumab or IV ravulizumab; all patients received SC ravulizumab during the extension period.
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PMC8481254
To further investigate the relationship between CDK19 and O-GlcNAcylation, we analyzed the effect of CDK19 overexpression and knockout and found that CDK19 overexpression led to increased O-GlcNAcylation levels in both Bel-7402 and Bel-7404 cells, whereas CDK19 knockout had the opposite effect.
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PMC11615101
The α-Taxilin mRNA levels were calculated based on qRT-PCR and represented as a bar graph, α-Taxilin was found to be significantly downregulated when transfected with 25nM/ml siTaxilin. (
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PMC11342785
Images are shown as a merge of the TPPP-FUS-FusionRed-PixD and TPPP-FUS-Citrine-PixE channels.
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PMC9436459
Cell or Target proteinActivity (IC50 in μM or μg/mL)Positive control (IC50 in μM or μg/mL)Mulberrofuran J (1)A549n.a.
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PMC2118063
Further analyses showed that cells with enhanced expression of IRF8 had increased levels of transcripts for mature B cell/GC-related genes AICDA and BCL6.
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PMC11300639
In recent years, the clinical application of antiangiogenic drugs has significantly improved the prognosis of patients with advanced ccRCC .
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PMC11768927
Modifying VSV to express immune-modulating proteins, such as GM-CSF, IL-12, or IFN-γ, can enhance local immune responses and improve viral oncolysis.
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PMC9429973
Summary/Conclusion: This prospective randomized trial will provide evidence for the use of PTCy for GVHD prophylaxis in matched-sibling PBSC transplants for acute leukemia in CR and MDS.
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PMC9454178
We found that THZ1-sensitive genes were associated with pathways involved in the regulation of transcription regulation by RNAPII (Fig. 6C).
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PMC5854676
Cell viability loss in HeLa cell line exposed to MgO nanotubes dispersed in darkness or with 660 nm laser irradiation.
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PMC11774747
Lymphodepletion and various sophisticated gene modifications have been explored to prevent such complications.
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PMC9429973
No grade ≥3 drug-related peripheral neuropathy occurred.
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PMC10577955
The C-NMR data were comparable to the reported for the lupene-type triterpene .
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PMC9429973
In previous work, we had shown that multiplexing several PDX cell populations within a single mouse in competitive in vivo experiments gives identical results to studying each population in separate mice (Liu et al., Biomarker Research 2020).
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PMC7823217
Many of these parameters need to be optimized to unveil the full potential of this technology .
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PMC11770199
In addition, we noticed that several pyroptosis-related genes were up-regulated (Fig. 2A).
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PMC5415764
Afterwards, the cells were resuspended with PBS and observed using an Incell 2000 Analyzer.
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PMC11265931
For the cell cycle distribution analysis, there is no significant change detected for HUVEC cells (Figure 4C).
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PMC9429973
Results: Clinical data of 124 patients with Richter syndrome was collected.
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PMC7215832
Promoters of genes are enriched with CpG islands and methylation of gene promoters has a silencing effect on gene transcription .
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PMC11438317
These results suggest that the proteins detected in the precipitates are likely LYP substrates and warrant further investigation.
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PMC7519871
Cell survival fraction values as observed in HeLa in response to different doses of BA.
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PMC11637276
Again, pharmacological inhibition of α2 integrin nearly abolished collagen I internalisation in YEJ P cells (S4E Fig).
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PMC11473750
The yellow horizontal bars signify the approximate locations of the membrane surfaces.
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PMC9429973
The coexistence of internal tandem duplication of FLT3 gene (FLT3::ITD) found in more than 70% of NUP98::NSD1 positive patients is always associated with a poor prognosis and results in high frequency of induction failure.
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PMC11721277
UV/VIS (DMSO) λmax, nm (ε, M cm): 269 (38,100), 400 (190,600), 498 (15,300), 528 (7500), 614 (7600), and 669 (61,000).
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PMC9429973
Pts at the first cohort of 20 mg QD daily (4/4; 2 female and 2 males) had no DLT and no dose interruptions.
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PMC10936243
It’s [bedding] just more for their welfare while they are boarding or hospitalised.
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PMC11727062
Brusatol, a lactone compound extracted from Bruceae fructus, is known for its ability to inhibit tumor cell proliferation and induce apoptosis.
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PMC11705547
FASN inhibitors are particularly effective against cancers with dysregulated lipid metabolism, and target multiple anabolic and oncogenic signaling pathways .
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PMC11574029
F Positive correlation between NOTCH3 and SPP1 expression as shown in the GEPIA database.
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PMC10560648
Besides, if there is an increase in p15INK4b expression, the prognosis will be better, and the effect of chemotherapy will be greater.
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PMC9964635
HRMS (ESI+): m/z calculated for [(C23H28N4OS)+H]: 409.2044; found: 409.2054 (Figure S31).
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PMC11803918
LED, 650 nm, 30 mW/cm, 0–120 s. (D) Representative CLSM images of ROS generation inside A375 cells after different treatments with or without light irradiation (scale bar: 50 μm; blue: Hoechst 33342, green: DCFH-DA probe; Xe lamp, 650 nm, 6.4 mW/cm, 12 min). (
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PMC11377827
n = 3, biologically independent samples, mean ± sd.
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PMC11769516
These substances possess antioxidant and anti-inflammatory properties, which have been widely demonstrated in the scientific literature .
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PMC11286266
ER stress treatments with 4 mM 2DG lasted 24 hr.
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PMC11736898
In addition to performing duplicates of cell cultures for each strain and condition, each RNA sample was analyzed in triplicate by qPCR.
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PMC6642070
The point mutations introduced into p53RRE3 are shown in underscore characters.
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PMC11267830
Cas9-expressing cells were transduced with either sgRNA-DCAF15 or nontargeting control sgRNA (sgNC) lentiviral particles.
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PMC11380329
The molecular network’s nodes represented the metabolites, and chemically similar metabolites were grouped together .
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PMC11746948
e GPX4 palmitoylation in A375 cells infected with lentiviruses encoding control shRNA or ZDHHC20 shRNA, and incubated with 50 μM Alk14 for 12 h, determined using the click chemistry assay.
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PMC9429973
The most frequent treatment options were R-DA-EPOCH or high-dose pulse immunochemotherapy.
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PMC11697189
N-O) Transwell migration and invasion were evaluated in the A498 cells (P-Q) Transwell migration and invasion were evaluated in the ORCS2 cells.
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PMC8973085
Found: C, 67.51; H, 4.60; N, 10.71.
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PMC11552389
Representative images of tumors harvested from melanoma xenograft models. (
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PMC11499381
There were very few differences in the Emax of these receptors; however, in HEK293S cells, CTR/RAMP1-C-V155–238 had a statistically significant lower Emax than the WT AMY1 receptor (Supplementary Table S1 and Figure S3).
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PMC11451940
1 : 15 v/v) mixture.
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PMC10094712
The results presented above showed the dose-dependent effect of hSELENOM on the Ca signaling system of cancer cells, which was observed during a long 24 h incubation of the cells with the protein.
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PMC9429973
Additionally, despite the presence of predisposing factors and the significant increase of platelets, no new thrombosis developed.
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PMC8389560
According to a commonly used method , A-172 cells were defined as apoptotic if the intensity of Hoechst 33,342 fluorescence was 3–4 times higher compared to Hoechst 33,342 fluorescence in healthy cells, indicating chromatin condensation which can occur as a result of apoptosis induction.
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PMC11593031
According to the ethical committee of the medical faculty and the Animal Experimentation Commission of Friedrich Schiller University, no ethical agreements are necessary for studies involving murine tumor cell lines, including Neuro-2a and its subclones.
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PMC11144382
Data are represented as mean ± SEM, n = 4, P <0 .05, P <0 .01, P <0 .001, P <0 .0001.
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PMC11658074
e SA-β-gal staining revealed differences in FB senescence among the four groups.
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PMC9545714
Golden tomato extract may provide benefits to the skin by enhancing innate immunity and other defense mechanisms in the dermis and by providing antioxidants to the skin surface to optimize TEWL and the appearance of the skin.
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PMC11413393
The majority of PRMT1 interactors correspond to RNA-binding proteins (blue circles), with the remainder corresponding to other proteins that do not fall into any significantly enriched categories (orange circles).
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PMC4277423
However, due to its lower sensitivity, the T7 endonuclease I assay can only detect off-target mutations that occur at frequencies equal to or high than 1% .
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PMC11739484
However, several limitations should be noted.
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PMC11320834
The assay was performed as previously described .
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PMC9429973
Image: Summary/Conclusion: 1.
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PMC9429973
Image: Summary/Conclusion: Almost one-third of HCPs found it challenging to understand their patients’ needs.
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PMC11144200
Still, this single adoptive immunotherapy strategy clearly has the potential to improve.
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PMC10652261
Piperazine is another common N-heterocyclic molecule that is regarded as one of the most vital building blocks of many major natural and synthetic anticancer agents.
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PMC11271800
In this review, we summarize the interaction between M2 macrophages and the programmed death receptor-1/programmed death ligand-1 pathway, which can improve the efficacy of imatinib by reactivating or enhancing the anti-tumor effect of the host immune system and provide new ideas for GIST immunotherapy.
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PMC11694625
The ΔGb of 3a–3d interacting with CDK2 (PDB ID: 4BGH) were summarized in Table S1.†3a–3d all showed interaction with CDK2 to some extent.
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PMC11653168
The dose-dependent nature of these responses further highlighted the ability of Stattic to effectively modulate these key cell death pathways (26).
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PMC3730428
Cell surface TNFR1 expression was assessed following live cell staining with Phycoerythrin-conjugated TNFR1 antibody, purchased from R & D Systems (Minneapolis, MN).
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PMC11443022
Although anejaculation due to impaired semen production associated with seminal vesicle atrophy was considered the primary cause, left microsurgical low ligation varicocelectomy was attempted to improve spermatogenesis.
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PMC10745221
In this case, we utilized 12% SDS-PAGE gels (GenScript catalog #M01215).
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PMC5417661
The average frequency of cell death started to rise significantly (P<0.001) in OvCar-8 (29.0%±9.0%) and CaOv-3 cells (46.0%±1.7%) 24 h after the treatment with 12.5 nM of NOV202 in comparison to the controls (2.3%±0.6% and 13.7%±2.5%, respectively, Figure 2B).
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PMC5574817
Fig. 7 shows a representative image of the hERG channel protein expression in hERG-transfected and non-transfected HEK293 cells .Fig.
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PMC10565698
Thus, it can be a stable, clinically valuable diagnostic and prognostic indicator.
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PMC11119602
The absence of the C-terminal domain causes TG2-S to adopt a conformation in solution, resembling the open state of the full-length TG2 that facilitates LC3 binding, as shown in Figure 7 .
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PMC11515150
It was demonstrated that CD5 CAR-NK cells exhibited rapid proliferation and potent cytolysis against malignant T cell lines.
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PMC9429973
Finally, GPR56 activation during hematopoietic differentiation results in an increased yield of CD34 CD38 cells, suggesting that GPR56 activity may influence the proportion of immature cells arising during haematopoietic differentiation.
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PMC11661040
They were kept in an SPF environment with adequate food and water for another 4 weeks.
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PMC7153288
The assembled genome of Streptomyces sp. SS1-1 produced four contigs of total length 7,815,656 bp and the coverage of 147-fold.
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PMC5916734
Raising the MTX concentration to 4 µM yielded an oligoclonal cell line with Qp = 5.97 ± 0.18 pg/cell/day, which was used for the second round of limiting dilution cloning.
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PMC11637276
Data are presented as the normalised mean ± SD; N = 5 independent experiments. *
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PMC11401350
4Anti-CD8-LVs encoding the CD4-CAR induced CD8 TIL expansion in murine AITL lymphoma biopsies and CD4 neoplastic T cell death.
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PMC11757230
Likewise, Nwabo Kamdje et al. demonstrated that human BMSCs exert anti-apoptotic effects on leukemic cells from patients with B-ALL, mediated by the activation of Notch signaling through cell-to-cell contact.
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PMC11787355
Whereas the mechanistic relevance of PTPRZ1 in glioblastoma remains elusive, its functions and contributions to disease malignancy are well-demonstrated, ranging from cancer cell proliferation and stemness to angiogenesis and therapy resistance.
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PMC11718274
Cells with diffuse DNA halos were classified as apoptotic, and the percentage of A-431 cells with diffuse DNA and a hazy outline was calculated based on a total count of 1000 cells.
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PMC7823217
Skin cancer or melanoma is one of the most common forms of cancers especially in Caucasian people consisting of different cancer types including non-melanoma skin cancer (NMSC), malignant melanomas (MM), Merkel cell carcinomas (MCC), basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC), that affects over 300,000 people annually across the globe .
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PMC10605143
The absorbance of the formazan product was measured (λ = 490 nm) using a microplate reader.
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PMC10723784
Cells were seeded in T25 flasks at 4 × 10 cells per flask and were incubated for 48 h or until they reached confluency.
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PMC11222184
In this assay, SH-SY5Y cells were seeded in a 25 cm cell culture flask and cells were exposed to XL-888 and Debio0932 separately for 48 h. Total RNA was isolated using a total RNA isolation kit, and these RNAs were synthesized into cDNA using a commercial cDNA synthesis kit.
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PMC10092581
Tested complexes as well as auranofin were pre‐incubated for 5 min at room temperature; reactions were started by the addition of 1 mM GSSG and followed spectrophotometrically at 340 nm.
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PMC11745600
FokI, FokI restriction enzyme; NOG, NOD/Shi-scid IL2rγc; TALEN, transcription activator-like effector nuclease.
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PMC10578720
Pearson correlation analysis based on immunofluorescence detection further validated the observation of Co-IP.
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PMC9577200
In contrast, GO had no significant impact on bacterial proliferation; it is not an inhibitor or stimulator of bacterial growth (Ruiz et al., 2011).
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PMC8345486
The doubling time was calculated according to the following equation: Td = 24 × (Tharvest − Tpassage) × log 2/(log N − log N0), where Tharvest − Tpassage indicates the time between passages (7 days), and N0 and N denote the number of cells initially seeded and finally harvested, respectively.
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PMC11675244
Lately, developing novel strategies to target these tumor compartmentalized cells represents a heterogeneous blend of therapeutic agents to minimize compensatory mechanisms by which tumors escape.
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PMC11696576
Mutations to MLL and MLL2 were also associated with sensitivity to AVX420.
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PMC10530622
The short-term nature of available data raises questions about the long-term effectiveness of lumasiran in treating PH1.
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PMC11587606
We then found that, in the 3D acinus formation model under Dox-on conditions, as RHBDF1 protein levels in the cells increased by about 9 times in 96 h, the protein levels of E-cadherin, Occludin and ZO-1 declined by about 40%, 50% and 70%, respectively, in comparison with that under Dox-off conditions (Fig. 1F).
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PMC9596868
PA-1 (ovarian teratocarcinoma cell line), A2780 (ovarian adenocarcinoma cell line) A2780cisR (ovarian adenocarcinoma cisplatin-resistant cell line), OVCAR3 (ovarian adenocarcinoma cell line) and HCT116 (colorectal carcinoma) cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) (High glucose with L-glutamine and sodium pyruvate) (HyClone, Cytiva, USA, Cat.
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PMC11548041
Cells were transfected with 0.5 μM β-catenin siRNA as a positive control.
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