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PMC9874064
A statistical table of IC50 values of BEL-7404, BEL-7404DPP and A549, A549DPP after 48 ​h treatment with cisplatin, NP-Pt and NP-Pt-USP1i.
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PMC11711345
Thus, studies on these cumin constituents should be considered to establish their potential anticancer action.
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PMC10142392
Several variables of polymer-based self-assembly need to be studied, including polymer/drug ratio, compatibility, solvent choice, self-assembly method, and solvent/water ratio during formulation preparation.
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PMC11422150
The most severe pretreatment symptoms from this BMS and BBB were nearly equivalent, indicating that the two groups were equally impaired.
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PMC11670954
A 20 μL mixture, consisting of 2 μL of cDNA template, 6.0 μL of enzyme-free water, 10 μL of SYBR premixed fluorescence quantitative PCR reagent, and 1.0 μL of upstream and 1.0 μL of downstream primers.
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PMC11574271
HIF-2α serves as a transcription factor for MMP12, promoting its expression and ultimately enhancing the migration and invasion of bladder cancer cells.
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PMC11659921
Additionally, we analyzed the expression variation of immune checkpoint‐related genes between the two clusters and found significant differences in all immune checkpoint‐related genes except for IGSF8 (Figure 4C).
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PMC11391695
In the future, we will study the cell membrane-encapsulated nanomaterials more intensively, and strive to realize the simultaneous targeting of ACYP2, KCNN4 and TERT for better therapeutic efficacy.
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PMC11767725
Elevated LDL and triglycerides, along with reduced HDL, shift the sebaceous lipid composition, favoring conditions conducive to pathogenic growth.
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PMC9429973
In order to further reduce the tumor burden, all patients were treated with bridging therapy before CAR-T cell infusion.
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PMC11075223
Therefore, new components and pharmacological activities still need to be further explored.
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PMC11577421
The cells were incubated with NPs (0.63 nM) for 2h at 37 °C in serum-free culture medium, and then processed as described above.
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PMC3019555
Bars, 10 µm.
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PMC9429973
Results: The median age of patients at diagnosis was 52 years (range 18-82), with 28.4% ≥ 60 years and 51.2% were male.
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PMC11770199
Methods: We constructed a fusogenic protein, fusion-associated small transmembrane (FAST) p14 of reptilian reovirus, into cancer cells and mesenchymal stem cells (MSCs), which cocultured with various colon cancer cells and melenoma cells to validate its ability to induce cell fusion and syncytia formation.
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PMC5941560
The following queries were used: jurkat[All Fields], jurkat[All Fields] AND apoptosis[Title/Abstract], jurkat[All Fields] AND (signaling[Title/Abstract] OR signalling[Title/Abstract]), jurkat[All Fields] AND (TCR[Title/Abstract] OR “t cell receptor”[Title/Abstract]), jurkat[All Fields] AND leukemia[Title/Abstract] OR T-ALL[Title/Abstract], and jurkat[All Fields] AND HIV[Title/Abstract].
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PMC11684269
Seemingly, this conclusion contradicts the data observed in lupus.
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PMC11762280
The scale bar in black is 100 μm for 10× magnification in D and E. The scale bar in yellow is 20 μm for 40× magnification in D. *P < 0.05. **
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PMC10578720
We found that in contrast to the control (0 IU/mL HBV), the SIRT3 protein and mRNA levels in human THP-1 macrophages were downregulated following HBV (10, 10, 10 IU/mL) stimulation, of which 10 IU/mL of HBV induced the most significant downregulation (Figure 3A).
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PMC10092581
An APH modified assay was used for determining cell viability in 3D spheroids, as previously described.
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PMC6182045
While the availability of anti-retroviral drug prevention and treatment strategies has significantly reduced mortality associated with HIV infection, the endurance of HIV transmission remains a major public health concern.
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PMC11721096
The active compounds in S5-C from the C. arabica extract exhibited very low polarity (Figure 6); thus, it was difficult to purify them.
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PMC9581083
An analysis of the literature has found that NRICM101 can reduce virus infections and replication withdrawal syndrome in patients with COVID-19 (Tsai et al., 2021).
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PMC9429973
In pts with aaIPI 1, two patients experienced a CNS relapse, one in the IT group and one in the non-IT group.
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PMC7504302
Interestingly, gene ontology analysis revealed that the most significantly enriched functional annotation group of these 191 genes was RNA splicing and processing.
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PMC10506676
EBV can easily infect cervical epithelial origin cells that are even infected with HPVs due to the abundance of EBV/C3d receptors on the surface of uterine cells (10-12).
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PMC11787381
Animals by sampling time: 3 animals.
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PMC4395774
As a surrogate for in vivo challenge, CD8 lymphoblasts cultured from the spleens of the reconstituted mice were used in an IFN-γ assay where the cells were co-incubated with target cells loaded with anti-CD3 antibody.
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PMC11678368
In contrast to trans-[PdCl2(5ClL)2], the Pd(II) complex with 4ClL shows only a single strong Raman band at 1679 cm, which corresponds to the C8=O1 stretch (calculated at 1719 cm).
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PMC11473843
Mutant KRAS: mutKRAS; n = 3. (
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PMC11588085
Based on our hypothesis, some X-linked genes that function in SC-specific pathways could be reactivated after XIST KD.
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PMC11746942
In addition, the persistent activation of STAT3 in psoriasis was attributed to elevated S1PR3 in the epidermal skin, resulting in positive feedback between S1PR3 and STAT3.
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PMC11803918
Ten days after implantation, when the tumor volumes were around 100 mm, the mice were intravenously injected with an equivalent volume of PBS, γδ-T exosomes, Ce6-loaded liposomes, or hybrid exosomes every 3 days for up to 4 doses.
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PMC8728081
Fig. 1 Conversion of Kajjali to Rasasindura, a) SEM backscatter image of Kajjali, b) and c) selected area EDAX results on big and small particles in Kajjali, d) DTA-TGA of Kajjali e) High-temperature XRD of Kajjali (at 25 °C, 120 °C and 325 °C) with comparison to metacinnabar and Rasasindura.
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PMC11322866
Western blot analysis results showed that EZH2 and H3K27me3 levels decreased in RRM2 OE cells ( Figure 2A).
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PMC11478724
Down-regulation of VDAC1 may deregulate the flux of ions, Ca (2+), and other metabolites across the outer mitochondrial membrane and cause inhibition of cell proliferation.
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PMC9429973
Treatment (tx) selection must integrate a myriad of clinical and patient factors, including disease resistance, cumulative toxicities and treatment efficacy, as well as patient quality of life (QoL) and the costs of therapies.
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PMC11803149
Virus supernatant was collected 72 h after transfection, and viral particles were concentrated by ultracentrifugation for 2-2.5 h at 24,000 g at 4°C with a Beckman Coulter Optima XPN-100 ultracentrifuge.
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PMC9412887
In their study, ATRA/CPT-NPs showed the strongest inhibition efficacy on the orthotopic BCSC-enriched tumor mouse models, suggesting that the differential drug release realized by ATRA/CPT-NPs was very important to strengthen the synergistic efficacy of ATRA-triggered CSC differentiation and CPT-triggered cytotoxic activity for the treatment of poorly differentiated and highly chemo-resistant heterogeneous tumors.
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PMC9429973
On average, patients received 3 previous therapies before ruxolitinib.
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PMC9429973
The MURANO study established the time-limited combination of 2 years venetoclax plus rituximab as a clinically important regimen for patients with R/R CLL/SLL.
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PMC9429973
The similar changes in 5 of these genes (PDGFRA, PDGFRB, ANG1, CFH, NES) were also found in NAA, but, with the exception of NES, the changes were not significant.
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PMC11767793
These assays produce toxicant dose–response profiles and can be performed using multi-sample platforms, combined with robotic arrangements.
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PMC9429973
After a median time of seven months post gilteritinib initiation (range 1-34), 12 patients (48%) achieved complete response (CR) with gilteritinib (figure 1A).
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PMC11753435
We reasoned that it may be feasible to cage UltraID by linking it with an IP capable of binding to the catalytic core and inhibiting its activity (Fig. 3B).
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PMC6024716
The chromatography was performed using ultrapure water containing 0.1% formic acid with 1 mM perfluoro heptanoic acid as solvent B and 0.1% formic acid plus 1 mM perfluoro heptanoic acid in 100% methanol as solvent A. The Liquid chromatograph tandem mass-spectrometry (LC-MS/MS) was run for 8.0 min with a flow rate of 300 μL/min.
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PMC11085211
Notably, FRs similarly impaired the viability of GIST cells and peripheral blood mononuclear cells (PBMCs), suggesting a non-specific mechanism of action.
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PMC11615828
n = 12 from 4 independent experiments.
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PMC11656657
RH41 SCMC), GD2 expression can be upregulated after exposure to the EZH2 inhibitor Tazemetostat, sensitizing tumor cells to the cytotoxic effect of CAR.GD2 T-cells.
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PMC11756514
This was followed by fractionation by size-exclusion chromatography (SEC).
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PMC9878562
The observation suggested the involvement of the LTB4/BLT1R axis in the cell-to-cell-induced migration of VAL cells.
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PMC11575040
Combined TargetScan and reporter assays revealed a direct link between miR-1270 and LINC00094.
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PMC9587866
Sorbifolin, (B) 1,7-Dihydroxy-3-methylanthracene-9.10-dione Prediction of Spectra of Activity of Screened Medicinal Ligands Structural Regions of (A) Sorbifolin and (B) 1,7-Dihydroxy-3-methylanthracene-9.
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PMC11759543
Carcinoma in situ Dimethyl sulfoxide Endoplasmic reticulum Fetal bovine serum Histone acetyltransferase Histone deacetylase Muscle-invasive bladder cancer Mitochondrial Permeability Transition Pore N-acetylcystein Non-muscle-invasive bladder cancer Poly(ADP-ribose) polymerase Reactive oxygen species Tris-buffered saline with Tween 20 According to the Globocan 2022 report of WHO Global Cancer Observatory, bladder cancer ranks 9th in terms of incidence and 13th in terms of mortality among all types of cancer worldwide .
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PMC11676674
By using Cyt-B, the scoring of micronuclei is restricted to binucleated cells that have undergone one division and prevents the scoring of unwanted micronuclei resulting from various factors like suboptimal cell culture conditions and changes in cell division rates .
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PMC10565698
Continuous addition of the circUSP10 overexpression vector led to further escalation of cell proliferation (Fig. 7C–I).
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PMC11730000
This effect was statistically significant at concentrations of 1000, 2000, and 4000 nM compared with the negative control group.
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PMC11001582
To determine whether TGF-β1 and COL6A1 have a role in polyGR-induced neurodegeneration in vivo, we utilized our Drosophila line expressing 36 polyGR repeats, which causes a moderate eye degeneration.
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PMC11413393
The type II PRMT inhibitor GSK591 (targeting PRMT5) also demonstrated significant growth inhibitory effects across our disease models.
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PMC8469018
However, recently Buettner et al. revealed that teriflunomide inhibits PIM family of serine/threonine kinases (PIMs) in MM cells, and in this way downregulates c-Myc expression and inhibits cell proliferation.
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PMC11317131
Von Willebrand Disease, the most common blood clotting disorder affecting 1% of individuals worldwide, is caused by mutations in vWF (67).
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PMC11594074
Consequently, the plethora of different cellular pathways targeted by compound 4 may be beneficial in overcoming these resistances in highly heterogeneous tumors.
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PMC11534377
19 uL of each master mix were loaded in the 96 well plates and 1 uL of cDNA was added directly in the plated in the corresponding place on the plate.
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PMC10253973
These complexes had anti-tumor activity in the 2D and 3D models of A2780cisR and A549cisR cells .
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PMC9429973
Median time to first response was 1.0 month (range: 0.7-3.3); median time to best response was 2.6 months (range: 0.9-13.6).
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PMC11621493
Statistical comparison in (H, L) were performed with unpaired two-tailed Student’s t test, and in (B, D, E, F, I, J) with one-way ANOVA followed by Bonferroni posthoc analysis.
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PMC11468365
The calculation for is provided in the following Eq. (19).19[12pt] $$_=^(_^- }_)((_^- }_)}^_^- }_)}^} ^_^- }_)}^}},$$=∑i=1n(yai-y¯a)((ypi-y¯p)∑i=1n(yai-y¯a)2∑i=1n(ypi-y¯p)2,where and indicate the mean value of actual and predicted values, respectively.
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PMC11194678
Data are presented as the mean ± SD of triplicate experiments. (
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PMC11098378
The lysate was then subjected to centrifugation at 10,000 x g for 30 min at 4°C.
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PMC7519871
Overall, both molecules showed satisfactory binding energies and can be considered as good candidates for the selected targets.
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PMC9960565
The low hematoxicity presented by the metallodendrimers was less or quite similar when compared to cisplatin.
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PMC11656048
However, it was found that the GSH/GSSG ratio declined after shikonin (1.5 uM) treatment and partially reversed by Fer-1 (10 uM) in MG63 and 143B cells (Figure 2R).
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PMC7153288
After that, the cell culture medium was replaced with the fresh medium containing various concentrations of the PY broth and the PY broth inoculated with Streptomyces sp. SS1-1 and left for 48 h. Then, the medium was discarded and 100 μl of serum-free medium and 10 μl of 5 mg/ml MTT solution (Biobasic) were added into each well.
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PMC10734950
Upon initiation of apoptosis, caspase 3/7 are activated to proceed with the process of apoptosis.
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PMC11562028
Tian et al. used three pentacyclic triterpenoids (PTs), including glycyrrhetinic acid (GA), ursolic acid (UA) and oleanolic acid (OA), as precursors to fabricate CDs under hydrothermal condition.
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PMC11754436
Furthermore, overexpression of miR-362-5p resulted in the opposite trend.
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PMC9351137
Cytokinesis failures results in tetraploid and polyploid cells with multiple centrosomes, which can lead to aneuploid daughter cells that would promote tumorigenic transformation [7, 20–22].
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PMC11095939
An Orbitrap Elite mass spectrometer was used to analyze the digested samples by Applied Protein Technology Co., Ltd (Shanghai, China).
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PMC9429973
In murine models, KRP203 efficiently reduced aGVHD.
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PMC11792888
The apparent IC50 value of each drug was used.
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PMC9429973
The obtained ORR was 88.3%, with 21.7% of patients achieving CR and 66.7% PR; median PFS was 51.8 months (95% CI: 47.4-56.2).
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PMC11607321
Compared to a multi-omic linear dimensionality reduction method, MOFA, and another VAE-based method MOVE, our model provides better separation of cell lines by tissue in the multi-omic latent space (Fig. 1c, Supplementary Fig. 1).
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PMC9119314
The extract was filtered (VWR qualitative filter paper 413) to remove particles of the plant material, concentrated under reduced pressure using a rotary evaporator (45°C), and dried in vacuo at 30°C.
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PMC8345486
Fast atom bombardment (FAB) mass spectra were recorded on a Finnigan MAT (Bremen, Germany).
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PMC10873328
It should be pointed out that the high-risk group had a higher PD-L2 expression, indicating that high-risk patients were more likely to benefit from immunocheckpoint inhibitor therapy.
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PMC7192625
We have provided extensive descriptions of the randomization procedures employed to assess significance of ChAs values obtained.
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PMC11474209
Anatoxin-A toxicity can be fatal owing to respiratory paralysis and includes loss of coordination, muscle fasciculation, and convulsions.
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PMC11206251
RT-qPCR was used to analyze the effect of the PEIM on the expression of P53 mRNA and caspase-3 mRNA from a genetic perspective.
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PMC11495567
However, we observe the activation of MAP2K1/2 (MEK1/2), MAPK1/3 (ERK1/2), and RPS6KA1/p90RSK through phosphorylation, which is consistent with our previous work .
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PMC11078693
The signal to noise of dye-probe combinations listed in this protocol is very high, and photobleaching is not a problem even without antifade, so that imaging with a water lens in PBS is preferable.
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PMC9096373
The maximum standard uptake values (SUVmax) of tumors within the ROIs were calculated using computer analysis.
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PMC11773391
It was reported that the tumour suppressor cytokine IL‐24 is downregulated during melanoma progression, and supplementing IL‐24 has been shown to reverse melanoma resistance to TMZ by downregulating MGMT .
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PMC9926039
In a former study, pioglitazone (a PPAR γ agonist) suppressed melanoma cancer in mice by inhibiting the TLR4 signaling.
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PMC10938336
Untreated control HL-60 cells and treated compound 2 (b) and compound 4 (c) using annexin V-FITC/PI double staining via flow cytometry.
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PMC9429973
Summary/Conclusion: Our results show that BMP2 has anti-fibrotic activity that is antagonistic to TGF-β.
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PMC7351993
The use of such thin glass substrates is important to avoid physical interference with a pair of high-NA objective lenses.
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PMC6889484
pVif2-HA expresses codon-optimized hemagglutinin (HA)-tagged Vif from HIV-2.
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PMC10847511
Platinum agents (shown in the top panel) and PARP inhibitors (shown in the second panel) exhibiting a trend for positive differences (Unadjusted P < 0.05) between the two groups are highlighted in red font.
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PMC9429973
Males and patients with education below high school were more susceptible to infection (P<0.05).
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PMC11052306
The length of the alkyl chain has a larger influence in the case of the copper complexes than in the case of the gold complexes.
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