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PMC6889484
Treatment for HIV-1 infection with potent combination antiretroviral therapy (cART) can control viral replication and delay onset of AIDS.
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PMC11756907
Data were analyzed with GraphPad Prism Software version 8.0.1 using bidirectional ANOVA with Tukey’s multiple comparison tests; The results for the ANOVA test were: p < 0.0001, n=3.
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PMC9318744
Decanoyl-RVKR-CMK (#3501) was purchased from TOCRIS (Bristol, UK).
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PMC6642070
Cell lysate was then centrifuged and the supernatant was collected.
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PMC10778532
We demonstrated an enrichment of genes regulated by hypoxia as well as genes implicating epithelial and mesenchymal transition (EMT) in the VHL-C162F cells.
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PMC11754432
Analysis of (B) RNAscope and (C) immunofluorescence staining of ALOX15B, data represented as mean dots/intensity per mm of the epidermis (N = 3).
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PMC11635519
PepA2 showed the lowest structural fluctuation per residue among the three peptides.
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PMC6461034
Tumor biopsies were taken both before and after 2 weeks of erlotinib treatment.
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PMC9509578
The xenograft model treated with FGB nanoconjugates also revealed suppression of tumor growth with pronounced apoptosis .
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PMC8873393
The response to DNA damage intersects with many other physiological processes in the cell, including initiation of DNA repair, chromatin remodeling, regulation of transcription and translation, and the cell cycle to contend with the challenge.
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PMC2118063
The purified RNA was reverse transcribed into cDNA (Invitrogen).
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PMC10213199
Purified mRNA was fragmented into small pieces using a fragment buffer at an appropriate temperature.
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PMC9429973
Therefore, we used the Pearson correlation coefficient to determine the potential m7G-related mRNAs.
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PMC5415764
MAL-PEG-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]) was purchased from Avanti Polar Lipids, Inc. (Alabaster, USA).
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PMC10571053
Additionally, rhodamine efflux was observed in the NCI/ADR-RES cells, but not in the OVCAR8 cells.
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PMC9596868
C-D) Percentage cell viability after combination treatment with quercetin and MST-312 in HCT116 cells.
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PMC9429973
These variant translocations involve others chromosomes in addition to chromosomes 9 and 22.
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PMC11786767
Upper: An example of the line scanning result.
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PMC11271278
G. Enhancer distribution of MYC and the additional oncogenes harbored in the amplicon found in NCIH446 cells.
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PMC7294030
Monolayers of cells were wounded by scratching with a 1 mL plastic pipette and then rinsed with phosphate-buffered saline (PBS) to remove cell debris.
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PMC11792090
The CytoFLEX flow cytometer (Beckman Coulter, Inc., California, USA) was then used to acquire flow cytometry data, and the data was analyzed using CytoExpert software.
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PMC11371747
Other cell lines: Jurkat (CD4 (+) T-cell leukemia), SW620 (colon cancer), CaCo-2 (HF) (colon cancer). (
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PMC11240052
Experiments was repeated three times.
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PMC11770199
The results showed that hMSCs-p14 fused with the neighboring cancer cells and formed multinucleated syncytia; subsequently, the syncytia were shrunk 20 h after coculture and died successively (Fig. 3A and Fig. S7).
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PMC11723210
The BPR method models the large phase sample as dual layers with object plane 1 and object plane 2 at defocusing distances of and , respectively.
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PMC8303372
GA is a compound with known antiproliferative properties aimed at cancer cells, and it is also able to interact directly with hepatocytes because it can bind to specific receptors on the surface of these cells, but it is not water-soluble.
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PMC11718031
However, for IS CHO-CD G17.4 and IS CHO-CD G17.7 cultures, osmolality remained between 250 and 340 mOsm/kg except for BalanCD-CHO Feed4, where it reached 400 mOsm/kg on day 11 (Supplementary Figs. S2, S3).
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PMC11591038
In a prospective clinical study, older women with a sleep-related breathing disorder, which was defined as an apnea–hypopnea index of 15 or more events per hour of sleep, have an increased risk for declined cognition as compared with those without this disorder .
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PMC9429973
Side effect profile was documented most common adverse event was elevated aminotransferases in 56%,six patient had (28%) had hyperpigmentation of sclera but their bilirubin was normal, abdominal pain in 36%.
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PMC9429973
The proportion of pts achieving a ≥50% reduction from BL in CS dose at any time was similar in the RUX and BAT arms (81.2% [134/165] vs 79.9% [131/164]) and RUX and BAT responders (81.7% [103/126] vs 86.9% [86/99]).
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PMC11794588
Every year, about 6 million individuals lose their lives to cancer, out of 10 million diagnoses.
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PMC11727000
Cells were incubated for 48 h with varying concentrations of mitomycin C, and metaphase spreads were prepared and analyzed as described .
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PMC11470381
Piezo1 mechanosensors are crucial for driving optimal T-cell migration by driving actin-cytoskeletal remodeling.
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PMC11271800
The TME in brain metastasis is suppressed to decrease CD4 T cells and M1 TAMs and increase M2 TAM infiltration.
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PMC9429973
The kinetics of NAbs were similar to controls except for levels at TP4 (p=0.02) (Figure 1).
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PMC10589262
Similarly, our findings showed that only a small portion of MT-KIT reached the PM and was rapidly degraded through PMQC.
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PMC11597291
The combination of DOX-loaded CGO with gold nanoparticles (GNP) was studied by Samadian et al. for the development of a theranostic nanomedicine system.
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PMC9429973
13.6%), C (28.3%), c (32.4%), E (19.3%), e (37.8%).
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PMC10362265
We obtained a single snapshot from the stabilized trajectory as the initial structure of the second simulation, which was carried out by removing the disulfide contacts (Fig. S1c).
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PMC11087301
In this regard, as time course of neoplastic transformation passed within human keratinocyte cells, inhibitor nuclear factor-kappa B alpha (IκBα), IκB kinase β (IKKβ), nuclear factor κB (NF-κB) RelA activation as well as Snail level were induced whereas suppression of NF-κB RelA sequestered the arsenite-promoted EMT, CSC-like phenotype acquisition, and neoplastic transformation.
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PMC11767817
In contrast, to detect the monomeric form of JC-1, excitation and emission wavelengths of 485 nm and 535 nm, respectively, were used.
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PMC11638255
Analyses were completed on FlowJo v10 (TreeStar, USA).
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PMC10560648
In recent years, the role of the marine ecosystem in the production of drugs, especially anti-cancer drugs, has been extensively studied.
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PMC11200978
Initial experiments revealed that concentrations above 500 nM resulted in complete A549 cell death in vitro, and therefore, the range of 10–100 nM was selected to determine the in vitro LC50 for A549 cells.
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PMC11529598
As expected, TP53INP1 knockdown not only enhanced proliferation ability of both miR-3154 sponge cells and control cells, but also abrogated the proliferation discrepancy between miR-3154 sponge and control cells (Fig. 5E-G, supplementary Fig. 4A).
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PMC11635519
The right panel showed the interactions of the N-terminal residue with the receptor binding site in the most representative cluster. (
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PMC8662250
The Caco‐2 undifferentiated cells were grown on glass coverslip (5 × 10 cells/well) and incubated for 24 h with DMEM; the medium was replaced with fresh medium, and the cells underwent treatments as described above.
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PMC8753818
But we reported that CRISPR system mediated caspase-7 silencing in CHO cell leading to a reduction in cell proliferation.
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PMC10958426
There're 8 patients among all 12 patients used in cell-cell communication analysis, other 4 patients are filtered due to few cells in many cell types or cells concentrated in few cell types.
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PMC11367146
Pratap Chandra Panda: Supervision.
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PMC11670407
After incubation, cells were rinsed 3 times with PBS, observed and recorded under a fluorescence microscope (Evos flauto, Life Technologies, USA).
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PMC11489175
The first DUB inhibitor that achieved clinical development is VLX1570 (Figure 4 and Table 2), a derivative of b-AP15 that inhibits both USP14 and UCHL5.
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PMC11684269
Furthermore, Hypoxia not only causes renal injury but may also be secondary to other diseases, thereby exacerbating kidney damage.
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PMC11655498
For example, the integration of metabolomics with CRISPR system has demonstrated that methionine metabolism is a significant pathway for maintaining EBV latency (Guo et al., 2022).
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PMC11551844
The samples were read using a FilterMax F5 (Molecular Devices) plate reader at 570 nm.
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PMC8992508
In fact, since the discovery and the clarification of the mechanism of action of the first efflux pump, modulation of the functions of P-gp and sister proteins has been considered an approach for fighting this kind of MDR.
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PMC11621493
For the purification of PLA2G4D, Expi293F cells were transfected in 10 ml or 25 ml culture volumes, respectively.
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PMC11753435
Protein lysates were subjected to gel electrophoresis using precast Bolt 4 to 12% Bis-Tris Plus Gels (Invitrogen, NW04127BOX) followed by nitrocellulose membrane transfer.
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PMC9429973
These results, that need to be confirmed in different series, open the way to innovating diagnosis assistance tools in the field of hematological malignancies.
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PMC4839679
We are reporting the novel observation of the increased representation of CE16:0, CE18:1, CE24:0, CE22:0 and CE22:4 upon PBRM1 re-expression, which have not be quantified in any study to the best of our knowledge (S3 Fig).
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PMC11610461
To increase the sample size of normal tissue sequencing specimens for PSENEN differential expression analysis, information from TCGA and GTEx databases was integrated.
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PMC9429973
Alternatively, allele-specific polymerase chain reaction (AS-PCR) to detect inserts belonging to the A, B, or D type (representing up to 90% of all inserts) is used.
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PMC9429973
During asciminib treatment 5 pts progressed to advanced stage disease, 9 pts eventually underwent SCT and 7 pts died of whom 6 with a CML-related cause.
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PMC10798140
Then, the treated cells were washed twice with 100 μL of ice-cold PBS (Gibco, Carlsbad, CA, USA) and centrifuged at 300×g for 5 min after each wash cycle.
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PMC11730000
Following the incubation period, the cells were washed twice with PBS.
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PMC10297204
Cells were then stained with 0.1% crystal violet for 15 min.
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PMC11679033
Two independent trials, with six experimental groups each, were conducted.
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PMC11538390
Quantitative RT-PCR reaction for each sample was performed in triplicate.
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PMC11585994
The gel displays G5, sgc8, and siBCL11B, along with siBCL11B combined with sgc8 and G5. (
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PMC11674891
Mice injected with GRPR-silenced A549-FLuc cells exhibited significantly reduced lung metastasis (Figure 6a and Figure S3a).
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PMC11583010
The gradient lasted 18 minutes from 30% B to 100% B, followed by a 2-minute hold at 100% B and then a 10-minute hold at 0% B. UV detection was monitored at 220 and 280 nm.
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PMC9118379
The remaining 28 (8.75%) spectra were consistently annotated as non-HEK_VP in explosive search by the three search engines, although they were identified as variant peptides in the original search by some search engines.
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PMC9429973
This trial enrolled eligible patients with histologically confirmed r/r-ENKTL failing from at least 1-line treatment; ECOG performance status ≤ 2; adequate organ function and bone marrow function; and at least one measurable or evaluable lesion.
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PMC3813807
Considering that miR-373 overexpression is able to increase the proliferation of gastric cancer cells, several predicted target genes associated with tumorigenesis or cell proliferation were subjected to a luciferase reporter assay in the present study.
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PMC11420784
ΔpldA grew as well as WT in LB and RPMI 1640 medium (Supplementary Figure 5), indicating that the decreased fitness of ΔpldA in vivo was not due to a growth defect.
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PMC11129910
To this end, immortal HMEC lines with a loss of RAB25 were created to observe the effects of RAB25 loss in vitro.
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PMC11470999
n.s.,
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PMC5415764
Although P-gp inhibitors have been combined with anticancer drugs to promote cytotoxicity previously36, the efficacy of co-delivery of drugs in a single carrier was much superior.
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PMC11672617
Substances were added at concentrations of 10, 1, 100, 10, 1, and 0.1 μM on the day after seeding and incubated for 24 h. Thereafter, the cells were washed with a PBS solution and stained with a 7-AAD dye according to the manufacturer’s protocol for flow cytometry.
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PMC11805741
PYT broth (10 g L peptone, 5 g L yeast extract, 5 g L tryptone), pH 8.0, was used as the optimized medium for carotenoid production.
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PMC9429973
Summary/Conclusion: This is a first in human clinical trial to evaluate safety, determine the recommended phase 2 dose and estimate efficacy of a novel microbial-derived peptide therapeutic vaccine, EO2463, in patients with indolent non-hodgkin lymphoma as monotherapy and in combination with lenalidomide and rituximab.
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PMC11632064
In future studies, it will be necessary to determine if resistance mechanisms are linked to an ability to maintain mitochondrial functions under PLK1 inhibition.
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PMC10919056
Therefore, it is clinically important to explore valuable prognostic indicators that can be used for personalized prognosis assessment and treatment planning, to ultimately improve the overall prognosis of patients.
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PMC11472639
Thus, the concentration of immune cells in whole blood conditions was 50% of the concentration observed in whole blood in vivo and therefore fewer effector cells might be responsible for this result.
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PMC9250505
A Xenograft: A2780 or A2780 cisplatin-resistant (5 × 10) cells were injected subcutaneously into the flank of 5-week-old BALB/c athymic mice, respectively.
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PMC11711066
VSMC calcification was induced by 2.6‐mM inorganic phosphate (Pi) using human aortic smooth muscle cells (HASMCs) for 6 days.
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PMC11344246
The image features were then centred and scaled into Z-scores.
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PMC11621493
Statistical analysis of untargeted LC-MS and RNA sequencing data is described in the corresponding materials and methods.
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PMC9429973
Of those with a diagnosis based on CSF studies, B-cell clonality was confirmed by flow cytometry (27/28; 96%), MYD88 mutation (18/28; 64%) and immunoglobulin gene rearrangement (12/28; 43%).
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PMC11474209
It is the smallest cyanotoxin, having a molecular mass of 165 Da and a bicyclic secondary amine structure with neurotoxic properties .
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PMC11413393
After 5 days of treatment, a population of cells with sub-2N DNA content (i.e. cells with DNA fragmentation) began to appear, while the number of cells in other phases of the cell cycle began to lag control conditions.
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PMC11592837
A constant increase was observed until 4 h (1.52), but the expected plateau leveled off after longer exposure times to a minimum (1.16) after 8 h of incubation.
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PMC10728200
Image acquisition was performed using Zeiss LSM780 Laser Scanning Confocal Microscopy (Carl Zeiss, Jena, Germany).
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PMC10758402
DMF’s demonstrated potential to suppress tumor growth, combined with oncolytic HSV’s tumor-selective replication and cytotoxicity, presents an opportunity for a multifaceted approach with enhanced therapeutic impact.
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PMC7841067
AKAP4 was highly expressed in thyroid cancer cell lines. (
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PMC10582828
In 2014, a new Asian human lung adenocarcinoma cell line that could also support the growth of coronaviruses was developed from a 61-year-old female Japanese patient.
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PMC3765139
CD133 expression in Na8 cells after 2D and 3D culture.
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PMC9219615
The Annexin V protein (~36.8 kDa) is a high-affinity ligand of PS, which, when conjugated to the fluorophore fluorescein-5-isothiocyanate (FITC), can be readily detected by flow cytometry when bound to PS.
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PMC11406030
Proposed mechanism of survival in epithelial ovarian cancer cells (A) Integrin αV and integrin β1 subunit levels were determined with commercially available ELISA kits on the 5 and 10 μg/mL recombinant LMTK3 protein-treated TOV112D cell line. (
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PMC7348793
In our case, PCR reactions generated mixes of fragments containing a number of 108 bp elements that ranged from one to the number of repeats contained in the plasmid used to spike the human DNA sample.
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