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PMC9429973
Compliance ratios were calculated as observed dosing frequency divided by the dosing frequency for FDA approved regimens (DARA-Lenalidomide-Dexamethasone [DRd] and DARA-Pomalidomide-Dexamethasone [DPd]).
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PMC11063646
Pankaj Kumar: Conceptualization, Investigation, Project administration, Supervision, Validation, Writing – review & editing.
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PMC11264242
We performed differential expression analysis of RNA sequencing (RNA-seq) data from SYO-1 cells transduced with a nonspecific (control) short-hairpin RNA (shRNA) or a SSX2 shRNA targeting the SS18-SSX2 fusion (Supplementary Figure S4) (McBride et al., 2018).
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PMC10652261
C NMR (75 MHz, DMSO-d6) δ (ppm): 42.81 (CH2), 44.30 (CH3), 46.16 (2CH2), 52.87 (2CH2), 62.71 (CH), 113.33 (2CH), 115.61 (CH), 116.77 (2CH), 118.68 (d, J = 7.50 Hz, CH), 124.73 (CH), 125.74 (d, J = 13.50 Hz, CH), 127.49 (d, J = 51.00 Hz, 2CH), 129.48 (d, J = 30.00 Hz, 2CH), 130.00 (C), 134.16 (C), 135.27 (C), 144.84 (C), 149.35 (C).
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PMC11725127
Intriguingly, using GA as a chemical probe, we reveal a novel allosteric pocket for inhibiting USP2.
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PMC11711127
Whilst NFAT is heavily implicated in anergy, it preferentially forms high-affinity complexes with AP-1 upon sufficient signalling to trigger typical effector genes (47).
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PMC11063646
The plates were removed after incubation and the spent media were aspirated.
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PMC11394386
This complex regulatory network underscores HOTAIR’s pivotal role in coordinating these pathways and its significance in cervical cancer progression (Figure 6).
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PMC11611077
In Eq (4), α is the slope factor of voltage-dependent charge transfer and is given by α=kTze (5) where k is Boltzmann’s constant, T is absolute temperature, z is valence and e is the electron charge.
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PMC11155445
Among the series compounds (106a and 106b) exhibited prominent inhibitory potential against Vibrio harveyi, with MIC 0.0156 mg mL. whilst compounds (106c and 106d) were found effective against Vibrio cholera and Vibrio parahaemolyticus having MIC values of 0.0313 mg mL and 0.0156 mg mL, respectively.
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PMC11082662
Correlations between variables were determined via Pearson correlation coefficients.
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PMC10482220
The results altogether indicate that G3BP is a stable component of SGs whose recruitment is influenced in a time-dependent fashion by p21.
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PMC11271278
We then sought to assess the regulatory function of enhancers on the MYC-ERBB2 ecDNA.
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PMC11502443
Type 2 diabetes (T2D) is a common metabolic disorder characterized by high blood glucose levels, due to low insulin or insulin resistance and affects more than 500 million people worldwide (Gallwitz, 2022).
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PMC9143157
More importantly, in the cisplatin-resistant A2780/cis xenograft model, compared to the anticancer drugs commonly used for epithelial ovarian tumors, i.e., cisplatin and paclitaxel, P-THP showed a clearly much improved antitumor effect, in which the tumor growth was almost completely inhibited up to 35 days after treatment (Figure 3D).
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PMC11715644
Over the past decade, cell collectives have been physically described as jamming of deformable bodies at high density, while unjamming requires a rise in internal forces and shape transitions.
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PMC11638255
f Bar plot of the proportion of immune cell subsets shown in (e).
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PMC11653533
In addition, the leaf wrapped around a finger is rubbed on the affected part to treat furred tongue, tonsillar, and throat inflammation; essentially, in ophthalmic conditions, water and shaken leaves are taken; besides, it has been reported that the leaves have anthelmintic and hypoglycemic potential (Oboh et al., 2014 Nov, Chhabra et al., 1984).
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PMC4685407
In this study, we used the CRISPER system without homology arms for gene-targeted recombination.
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PMC9429973
Further investigation would be of great interest in an attempt to clarify the functional role of these polymorphisms in the development of the disease.
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PMC9429973
Summary/Conclusion: These data provide insights into the long-term feasibility and tolerability of fSCIG administration at home or in a medical facility in patients with SID primarily due to hematologic malignancies, including in older patients aged ≥65 years.
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PMC10547921
Besides, ADCs with DNA inhibitors as payloads can target tumor cells with low antigen expression, which explains why DNA inhibitors have been chosen as payloads in many next-generation ADCs.
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PMC9429973
Results: Seven AML patient samples were screened in a 5-day ex vivo assay using a library of 21 low toxicity approved drugs with known myeloid adverse effects.
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PMC10994876
Based on these findings, it can be inferred that the observed cell cycle progression is likely attributed to the increased expression of c-MYC.
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PMC11185260
Some animals also received total 3 injections of cisplatin (2mg/kg, weekly for 3 weeks) and/or 3 fractions of radiation (5Gy, weekly for 3 weeks). (
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PMC10196713
Therefore, it can be assumed that cisplatin induces cell death through ferroptosis in addition to DNA breaks, and that cisplatin-resistant cells may acquire ferroptosis resistance.
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PMC11087766
We were unable to accurately measure the kinetics of PhiKZ RecA-sfGFP import in early infection due to its tendency to form foci in the cytoplasm prior to import.
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PMC11429241
This allows the creation of highly detailed and complex 3D micro- and nanostructures with a sub-micrometer resolution.
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PMC10006224
Primers used are listed in Supplementary Table 6.
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PMC9429973
Aims: To identify clinically significant co-mutational patterns in NPM1 AML in order to establish a revised risk stratification model.
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PMC2944824
Data are expressed as means ± S.E.M. ** and *** indicates significantly difference between knockout and wild-type at p<0.01 and p<0.001, respectively, which was determined with ANOVA and Tukey's post hoc test.
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PMC11502443
If the Hill slope was not equal to one for the majority of independent experiments in a dataset, this parameter was unconstrained, and pEC50 values obtained.
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PMC9429973
X. Du, L. Wang, W. He, Q. Li, L. Tang, X. Feng, P. Zhou, N. Zhao, X. Zhang, C. Song Medical center of hematology; Nursing department; Department of gastroenterology; Internal Medicine-Neurology; Operation room; Department of President Office, Xinqiao hospital Army Medical University, Chongqing, China Background: In clinical work, nurses are the direct caregivers of patients, and they need to cooperate with doctors to observe patients’ conditions and carry out a number of clinical operations.
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PMC11496728
The SEAP concentrations in pCMV-IL3, pCMV-IL3-1, and pCMV-IL3-2 transfected into CHO-KO cells were increased by 1.68-, 1.61-, and 1.52-fold, respectively.
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PMC11462929
Thus, we hypothesized BENC‐CNA provides the in vitro proliferative advantage to BCP‐ALL cells by enhancing MYC.
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PMC11634027
We also found that V5-tagged DCHS1 can co-precipitate Dachs, consistent with the conclusion that Ds-Dachs association is mediated by a conserved motif.
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PMC9429973
The physical functioning scale was worse in the VMP vs Rd arm at 3 (-7.8 vs +0.04; P=0.070) and 6 months (-8.2 vs +3.2; P=0.013), with no differences in later time points.
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PMC10495912
In addition, there is evidence of the TQ effects on preventing the growth and proliferation of different types of cancer cells (Fatfat et al., 2019; Almajali et al., 2021).
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PMC6034753
Bound protein were resolved on an SDS Bis-Tris gel along with 10% of input protein and western blotted with FLAG antibodies.
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PMC11705862
Graphs represent the ratio of band intensity for IRIS-1 or 2 to β-tubulin.
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PMC9429973
Translocations t(11;14) and t(4;14) were observed in 15% of cases each and t(14;16) in 10% of patients.
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PMC11519788
Tumor size was measured every 3 days for 4 weeks.
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PMC11720808
First, stable pLVX-TLR4-FLAG overexpressing cells were established, then TLR4 mRNA levels were measured by qRT-PCR assay, and the endogenous and exogenous TLR4 protein levels were assessed by WB.
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PMC11144200
Fig. 4In vitro cellular uptake and in vivo biodistribution of LPS-RGD-Nb36-DOX.A–D Fluorescence signal distribution of Hep3B or A-427 cell tumor-bearing model at 2, 4, 8, 12, 24, 48, and 72 h post-injection of Free IR, IR-LPS, IR-LPS-DOX, IR-LPS-RGD-Nb36, IR-LPS-RGD-Nb36-DOX, and IR-LPS-RGD-Nb36-DOX + FC-activated CD8 T cells.
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PMC9429973
R. Greil, K. Kopeckova, L. Arcaini, A. Amin, K. de Graaf, A.-M. Jegg Paracelsus Medical University, Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials (SCRI-CCCIT); Cancer Cluster, Salzburg, Austria; Department of Oncology of the 2nd Faculty of Medicine, Charles University and Motol University Hospital, Praha, Czechia; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy; MorphoSys AG, Planegg, Germany Background: Tafasitamab is an Fc-enhanced, humanized, anti-CD19 monoclonal antibody which, in combination with the immunomodulatory drug lenalidomide, has been granted accelerated FDA approval and EU conditional marketing authorization based on results from L-MIND (NCT02399085) for the treatment of relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) in adult patients ineligible for autologous stem cell transplant.
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PMC11740207
However, a very intriguing possibility is that VSLSLCs exclusively possess the ability for SD, or their presence is required to facilitate SD in more differentiated SCs.
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PMC11739696
However, the therapeutic efficiency of Co3O4NPs against melanoma cancer has not been fully explored.
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PMC9429973
In the CASTOR trial, pts with a GFR < 20 ml/min were excluded.
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PMC11407042
32.Subtract the average values of the culture medium background from all values of experimental wells.33.Use the corrected values in the following formula to calculate percent cytotoxicity: percent cytotoxicity = 100 × mutant A490/wild-type A490.
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PMC11321678
The positive correlation of these two scores indicates the positive TF regulatory.
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PMC10253973
After the introduction of a drug into neoplastic cells, the tissue target is irradiated at a specific wavelength of light .
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PMC11201245
The existence of true non-diploid cells can be assumed if a signal distribution that deviates from the diploid pattern occurs more frequently than in 36% of the interphases examined.
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PMC4485648
Afterwards, the cells were washed with PBS buffer and measured.
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PMC11387401
It does provide, however, further evidence that AFF2 plays an essential role during HIV-1 infection.
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PMC11785489
Each TCR sequence exhibited greater CD69 upregulation compared to baseline (fold change > 1), confirming specific reactivity to the MART-1 antigen.
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PMC11443022
This report aims to present a case study of a 45,X/46,XY mosaic male patient with an ejaculatory disorder attributed to seminal vesicle dysplasia.
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PMC11026382
Expression was induced with 1 mM IPTG when the cells reached an OD600 = 0.6–0.8, and the cells were then grown at 18 °C for 16–18 h before harvesting pellets for storage at −80 °C.
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PMC8875242
The model ABCB1 inhibitor CP100356 , the ATP bioluminescence assay kit, DMSO, Dulbecco’s Modified Eagle Medium, ethanol (EtOH), fetal bovine serum, nonessential amino acid solution, and penicillin–streptomycin solutions were purchased from Sigma-Aldrich (St. Louis, MO, USA).
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PMC11612794
Asterisk indicates nonspecific bands.(E) Magnified view of the Mis12C-Head1 hydrophobic surface interacting with the binding region 2 of CENP-T. Left: The transparent surface model of Mis12C is overlaid on a cartoon model.
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PMC11653168
A statistically significant reduction was observed at 1.25 µM, and cell viability was further decreased at 2.5 µM and higher concentrations.
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PMC11604768
RNA fractions were eluted in 30 µL nuclease-free water.
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PMC7053076
Fig. 4Real-time PCR analysis of c-Rel, RelA, RelB, NF-κB1 (p100/p50), and NF-κB2 (p100/p52) mRNA levels in HL-60 cells treated with U-332 (a) and BGD (b).
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PMC11519583
The asterisks indicate nonspecific bands (Immunoglobulin heavy chain of antibodies), and triangles show the Wnt11-Flag bands.
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PMC11708541
2-Aminopyridine (2-AP) 9 is a completely functionalized, low molecular weight moiety used in the synthesis of many different biological compounds, being synthesized by a large number of pharmaceutical companies worldwide.
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PMC11343332
Photographs were taken using an inverted microscope (Euromex, The Netherlands).
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PMC11665555
The 5637 cells (2 × 10 cells/mL) were grown until confluent in 12-well tissue culture plates.
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PMC9429973
ACA-O scored the best in PFS in an unselected population (SUCRA 100%, probable the best 99.9%), UN- and MU- only CLL patients.
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PMC11307990
The cell viabilities of 786-0 cells after treatment with a mixture of 6HB-DONs, SUN, and DNA nanotape-SUN for 24 h were evaluated with a CCK8 assay.
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PMC2192239
As this phosphorylation was independent of protein kinase C activity, we tested whether a calcium/calmodulin-dependent protein kinase (CaM kinase) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations.
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PMC10547921
To obtain a payload that can be easily integrated and retain potency, Peter D. Senter prepared a series of FK-866 analogs with aniline substitution at different locations on the aromatic tail.
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PMC9429973
Methods: Adults (18–65 years) with documented NTDT (including β-thalassemia intermedia) who provided informed consent, were included.
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PMC11240052
Expression ratio of circ-0008285 in SKOV3 and A2780 cell lines. (
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PMC11502066
In parallel to the increasing evidence about the involvement of various GPCRs in cancer initiation, development and progression, the findings of flavonoids on interfering with these processes have become more and more important.
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PMC11798926
It has been proposed that the function of this family of molecules is to act as “fusogens” by either promoting or inhibiting membrane fusion (Coomer et al., 2021).
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PMC11756907
The final concentration of phosphatase in the reaction samples was 1.5 µg/mL (3.3 nM).
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PMC9430060
Results: We confirmed that the insertion of a single IGH super enhancer (Eα1) in U266 leaves the local topologically associated domain (TAD) structure intact.
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PMC11794847
Next, we used mIHC to identify the subcellular localization of HVEM and found that the HVEM (green) was expressed in the cytosol of CD4 and CD8T cells (FigS1A–B).
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PMC9429973
All patients received R-CHOP (median 6 cycles; range 1-8).
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PMC8348645
The morphological observations made during the assay revealed that there is a significant decrease in the viability of the cell as the concentration of the induced W. somnifera extract increases, thus indicating the anti-proliferation activity against the HepG2 cell line.
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PMC11095939
DNA quality was assessed using an Agilent bioanalyzer and quantified using a Qubit fluorometer.
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PMC11770746
We encapsulated cisPt(Pac)OH complexes inside lipid-based micelles, which enhanced their solubility and stability, with the aim to further facilitate drug accumulation at the diseased areas by taking advantage of the “leaky” vasculature at the tumor site (described as enhanced permeability and retention (EPR) effect).
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PMC11790599
The mean fluorescence intensity of the population was determined.
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PMC10440586
P value <= 0.0001, ***, P value <= 0.001.
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PMC10222971
The human embryonic kidney 293 (HEK 293) cell line was developed in 1977 from the sheared Adenovirus 5 (Ad5) DNA transformation of the human embryonic kidney cell .
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PMC8526701
Together, our findings indicate that PUMA is required for the combination of BRD9 inhibition and imatinib.
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PMC11694625
In the late stage of apoptosis, the nucleus can break into fragments, producing apoptotic bodies.
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PMC11371627
Supplementary Table S1 gives an overview of the observed XK variants and their clinical manifestation.
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PMC11509224
The in vitro biological activity evaluation showed that compound 199 had cytotoxic activity against the K562 cell line, with an IC50 value of 7.3 µM. A bicyclic diterpene, jellynolide A (201), with a penta-substituted carbon skeleton, was also isolated from this sponge .
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PMC11626627
Validation of the effects of ERβ and TWIST1 was performed using Western blotting (A) and qRT-PCR (B) in 786-O cells transfected with pLKO.1, sh-ERβ#2, oe-TWIST1, and sh-ERβ#2+oe-TWIST1.
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PMC11750712
For cohorts 2 and 3, if no CAR T cell expansion was detected in any of the patients treated (with at least one patient treated at that dose), together with no grade ≥ 1 CRS/neurotoxicity or ≥grade 2 AUTO4-related adverse events in the DLT period (first 28 days after AUTO4 infusion), accelerated escalation to the next level was allowed.
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PMC2777936
Therefore, canonical Wnt signalling, as measured by Wnt reporter activity, is minimal in basally growing EC cells and activated as these cells are induced to differentiate.
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PMC11740399
The results indicate that 3025@ML is a promising therapeutic strategy for overcoming OXA’s compromised therapeutic effect and potentially improving cancer treatment outcomes.
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PMC11564322
VGVAPG and VVGPGA peptides do not affect the metabolic activity of HL-60, K562, and MEG-A2 cells. •
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PMC11045125
The resulting PCR product was purified using QIAquick PCR purification Kit (Qiagen) and sequenced by GeneWiz (South Plainfield NJ).
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PMC11676670
The standard treatment approach to HGSOC includes primary cytoreductive surgery followed by platinum-based chemotherapy.
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PMC11674441
Neoantigen analysis was conducted as previously described .
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PMC9693627
We found that functional deletion in the PTCD2 gene significantly decreased translation efficiency of COIII mRNA and led to reduced steady-state level of this mitochondrially encoded protein.
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PMC8992508
The development of multidrug resistance (MDR) is one of the major challenges to the success of chemotherapy treatment of cancer.
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PMC5600151
Schatzlein et al. reacted the primary amines on PPI with methyl iodide and used this quaternized PPI for DNA delivery.
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PMC6617630
For thymidine incorporation assay, 1.0 × 10 cells were cultured for 72 h with bromodomain extra-terminal inhibitors (BETi).
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