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PMC11604768
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC11087055
Diagram of experimental set up. (
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PMC9596868
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC9429973
Median duration of response was not reached.
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PMC9672323
Moreover, although statically not significant, a high concentration of piroxicam impeded TGF-β levels in both U-87 MG and A-172 cells.
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PMC9429973
Israel is enriched with multiple ethnicities and high consanguinity.
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PMC11388384
In a different type of tissue, such as epithelial sheets where the degree of intrinsic cell–cell contact is smaller, cytonemes might have a more important contribution to cell–cell connectivity, and possibly morphogen gradient formation, as suggested by studies in the neural tube (10, 51).
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PMC11412721
Means ± SEM from >3 independent experiments with at least two independent MEF clones per genotype. (
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PMC11401358
AFM images were obtained using an AFM (Cypher S, Asylum Research, Morrisville, NC, USA).
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PMC11683240
B, D, F, H, J, L, and M) significance was tested using one-way ANOVA followed by Dunnett’s multiple comparison test and refers to samples treated with PT only (B, D, F, H, and J) or untreated control (Con) (L and M) (∗p < 0.1, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns not significant).
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PMC5035325
4Combinatorial targeted therapy to the EGFR and NeuGcGM3 ganglioside in two lung metastasis models of mice: Lewis lung carcinoma (3LL-D122) in C57BL/6 (a-c) and mammary carcinoma (4T1) in BALB/c (d-g) .
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PMC9429973
The present study shows the recovery sequence of different parameters over time following initiation of treatment with siltuximab.
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PMC11734514
Additionally, Western Blot analysis was adopted to assess PTEN, p-Akt, Akt, p-mTOR, and p-STAT-3 protein expressions.
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PMC11798926
We quantified the integrated density of the α-Flag signal that overlaps with Golgin-97 and determined there was a highly significant increase in signal relative to mock transfected cells, which had very little internalized signal (Figure 3D).
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PMC11258145
With the increase in curcumin concentration in one-component systems, i.e. DPPC, DOPC, cholesterol the Cs values decrease.
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PMC3035438
We also analyzed the amounts of chimeric IgG secreted in the culture supernatants by quantitative ELISA (Figure 4D).
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PMC11283030
ORO staining showed that there were less red LDs in 786-O and A498 cells after ACLY knockdown (P < 0.001, P < 0.001, respectively, Fig. 5d).
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PMC11633763
To investigate the effect of USP22 on tumour growth in vivo, shNC‐143B and shUSP22‐143B cells were subcutaneously transplanted into female nude mice.
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PMC11772449
The scores of BEL-7404, Huh-7 and PLC/PRF/5 were 13.51,13.705 and 15.019, respectively, which were all higher than 10, indicating that there was a drug synergy between Sora and pirfenidone in the four liver cancer cell lines.
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PMC11461874
The range of the circadian period was set to 20–28 h according to the default settings.
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PMC9841531
The pH calibration was carried out for each plate by adding 100 μL of intercellular pH calibration buffers for pH 4.5, 5.5, 6.5, and 7.5 (Invitrogen by Thermo Fisher Scientific, Eugene, OR) with 10 μM of nigericin and 10 μM of valinomycin to each well, followed by an incubation period of 30 min at room temperature.
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PMC11661040
To acquire the MG63 and 143B cell line with stable CGREF1 knockdown (MG63-shCGREF1 and 143B-shCGREF1), MG63 and 143B cells were infected with shCGREF1 lentivirus (MOI of 143B = 20, MOI of MG63 = 100) using 5 µg/mL polybrene transfection reagent (OBiO Technology, Shanghai, China) and cells were selected with 5 µg /mL puromycin (Servicebio Technology, Wuhan, China).
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PMC9429973
STIMULUS MDS-US (NCT04878432) is a US-based, open-label, single-arm, ph II trial of sabatolimab + HMA of investigator’s choice (AZA intravenous [IV] or subcutaneous, decitabine IV, or oral decitabine/cedazuridine) in pts with vH/H/IR-MDS.
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PMC9429973
The incidence of grade 3/4 hematologic adverse events (AEs) was also higher in the RAD group than in the PAD group (66.7% vs. 28.6%, P=0.033).
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PMC11612315
The products were then separated via SDS‒polyacrylamide gel electrophoresis, transferred onto nitrocellulose membranes, and blotted with an anti-TRPV1 antibody (#ACC‒030; Alomone Labs, Jerusalem, Israel).
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PMC11754094
P = 0.0072 for large deletion between ART558-treated and non-treated HeLa cells.
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PMC9684669
The rise of CAMK2D and its active form, phosphorylated-CAMK2D (T286), in A2780-ADR cells was confirmed by Western blotting ( Figure 5B and Figure S5A ).
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PMC11463018
White solid, 74.6% yield.
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PMC10852540
Therefore, IC50 RA and IC50 DOX incubation were selected for the analyses in this study.
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PMC11026382
Metabolites are in gray or black italic text.
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PMC6889484
The results showed that NL4-3 replication was readily detected in the CEMSS cells, but no virus replication was detected in the CEMSS/D128K cells for 42 days, indicating that resistance to A3G-D128K did not emerge after prolonged culture, even in the absence of endogenous A3 proteins.
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PMC9429973
D5PSS-5:10/15 patients with D5PSS-5 received salvage chemotherapy [9 with stable/progressive disease (SD/PD) and 1 with partial response (PR)], whereas 5 patients with PR underwent RT.
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PMC7185206
P < .001, ** P < .01, * P < .05.
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PMC11546117
The medium was changed every 2–3 days.
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PMC10936243
Not enough manpower to clean, cages not big enough.” “
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PMC11694066
Clinical prognosis for advanced DSRCT remains poor with a 5-year survival rate below 15% (2).
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PMC9429973
They were enrolled after 1 or 2 prior therapy if their frailty score was ≥ 2 by IMWG score.
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PMC3765139
B: Clonogenic capacity of D10 cells.
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PMC11615828
The cells were resuspended in a Neurobasal (NB) medium containing 1 × GlutaMAX supplement, 12.5 µM glutamate, 1 × penicillin‐streptomycin, and B27 supplement.
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PMC11400680
Once the prompt generator is fine-tuned, it can be applied to produce bounding box prompts which are then utilized by the SAM for further mask generation.
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PMC11224020
cPLA2 is in gray, and nuclei are in red; scale bar, 10 µm.
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PMC11237030
In this scenario, developing monoclonal antibodies against AQP5 extracellular loops will potentially open the way for the development of new diagnostics and therapies in SS.
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PMC5363531
BACT served as housekeeping control.
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PMC11594074
A crucial epigenetic modification in cancer development and progression is DNA methylation, which is modulated by the methyltransferase DNMT1.
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PMC10669966
We were unable to find any PDE3A-positive MLPS cell lines for the study.
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PMC11621493
PLA2G4D also acylated 2-arachidonoylglycerol (2-AG) resulting in the formation of arachidonic acid containing DAG.
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PMC10728200
The up-regulation of FTH1 and down-regulation of TFR1 may be caused by negative feedback (Fig. S10).
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PMC9847912
This second pair of oligonucleotides preserved the point mutation that encoded the methione 364 to leucine change, which was introduced into pROD9 in the first round of reactions (nucleotide bases indicated in bold type).
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PMC10125312
Differences between 0 and 24 h are shown in the graphs.
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PMC10380508
However, in various types of cancer, including RCC, PAX genes can be re-expressed in an aberrant manner, contributing to abnormal cell proliferation and cancer cell survival .
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PMC11551844
Cells from A172, CCD18Co, DLD1 and TERA1 at a density of 6.0 × 10 cell per mL were transferred into 96-well plates.
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PMC11777207
Prior studies identified several key amino acid residues necessary for facilitation of binding with PD-1 such as PD-L1 residues A121, D122, Y123, K124, and R125, with the most critical residues being D122 and Y123 (32, 33).
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PMC9429973
For this reason, an approach based on erythroid TFR2 targeting would avoid the side effects of the available therapies.
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PMC11634794
Kaplan-Meier survival analysis of the relationship between prognosis and different clinical variables in ccRCC patients. (
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PMC11788920
The PQS and the G-tracts are indicated in the schematic.
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PMC9429973
Ninty-one patients (77.8%) prophylactically received antibiotics.
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PMC10955424
The p-values between the untreated and JAK inhibitor-treated samples in the presence of malignant ascites and RJY13 were not statistically significant (p = 0.4–0.8) (B).Fig 3 JAK inhibitors partially restore chemo sensitivity to OC cells mediated by malignant ascites-fluids.
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PMC9429973
To evaluate the predictive value of D-d on TE risk and survival in patients at ICU admission, a logistic regression and a ROC analysis were performed.
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PMC9429973
Nomograms were established to predict survival possibilities.
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PMC11354225
Therefore, the concentrations used in this work would not be sufficient to generate the EGCG pro-oxidant effect.
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PMC11626627
Total protein was extracted, measured, and then separated by 8–15 % SDS-PAGE electrophoresis.
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PMC11653168
Female NOD/SCID mice (age, 9 weeks; weight, 18–22 g) were procured from the National Laboratory Animal Center (Taipei, Taiwan).
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PMC9429973
Median prior therapies was 3 (2–7); 59% had ≥3 prior therapies and 35% had received prior CAR T-cells (CAR-Ts).
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PMC9727330
As a negative correlation, the depletion of ASNS by NNDAsp in colon cancer cells activated the expression of P53 and stimulated the programmed cell death in treated cells.
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PMC7823217
Developed constructs were able to better mimic glioma microenvironment, which was supported by observed resistance to chemotherapeutic agents and higher expressions of tumor invasiveness markers including vascular endothelial growth factor receptor-2 (VEGFR2), matrix metalloproteinases (MMP2, MMP9) and O6-methylguanine-DNA methyltransferase (MGMT).
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PMC11244823
comm.
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PMC9429973
VEN dosing was adjusted for pts on concomitant CYP3A inhibitors.
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PMC11401358
Caudal fin amputation in zebrafish is an effective endogenous sustained H2O2 accumulation model , and we determined the antioxidant capacity of SF in Tg(mfap4:EGFP) transgenic zebrafish larvae (Fig. 3F).
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PMC11354239
In recent years, significant progress has been made towards understanding the critical role of natural killer (NK) cells in the immune response to tumors.
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PMC9429973
The microbiological or radiological proven infectious complications (almost one) occurred in 160/230 (70%) of pts, mainly pneumonia (in 42% of pts) and/or bacteremia/sepsis (one or more events in 29% of pts).
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PMC9581083
This formula combines the four classics of Xiao Chai Hu Tang, Shegan Ma Huang Tang, Maxing Shigan Tang and Wuling San (Liu et al., 2021c).
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PMC9917080
Therefore, SELENON deficiency increases the sensitivity of cells to the consequences of ER stress, increases the lipotoxicity of saturated fatty acids, while reducing insulin sensitivity .
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PMC7081114
The cells were incubated with Annexin V–APC for 15–20 min at room temperature in the dark.
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PMC10335954
Finally, microarray analysis of TRIP13-related pathways was performed to identify the potential underlying mechanism of TRIP13 in gastric cancer.
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PMC11643361
However, this was less pronounced than the hydrogen peroxide production elicited by antimycin, a classic inhibitor of the mitochondrial respiratory chain at the level of complex III.
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PMC9429973
Pts ≥70 years were at a higher risk of death in remission.
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PMC11489351
This analysis was performed on the raw RNA-Seq data which was used to generate main figure pathway maps.
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PMC11594074
These findings are in line with our results, indicating that compound 4 dose-dependently increased apoptosis and thereby decreased tumor cell proliferation.
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PMC11429241
Here, spheroid scaffolds even offer some relative simplifications to the process, such as the resolution requirement not being as strict at ∼1 m. Also, spheroid scaffolds do not need to be bigger than ∼mms in overall size.
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PMC11767817
Curcumin can also be used as an adjuvant in cancer therapy to sensitize the cells to chemotherapeutic agents and overcome drug resistance .
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PMC6034753
These assays were performed in three independent experiments, essentially as described previously .
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PMC9844987
Furthermore, we observed an inverse correlation between variability in promoter activity and the number of cell types (FANTOM Consortium and the RIKEN PMI and CLST (DGT) et al., 2014) and tissues (Battle et al., 2017) the corresponding gene is expressed in (Spearman’s rank correlation ρ = −0.21 and −0.15 for cell types and tissues, respectively, p< 2.2 × 10; Figure 3B; Figure 3—figure supplement 1B), demonstrating that highly variable promoters are more cell-type and tissue specific in their expression.
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PMC11551844
Pure compounds, namely, contignasterol, ansellone A, motuporamines A and MN100 (a synthetic analog of pelorol), were also used.
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PMC11672142
An EPR spectrum was collected to determine the Fe(III) coordination (Figure 1C).
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PMC11577421
Presumably, the reduced negative charge of BSA at lower pH leads to decreased long-range repulsion toward heparin, thus promoting stronger interactions between the two molecules.
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PMC11742047
The use of these compounds as therapeutics was further boosted when the endogenous cannabinoid (or endocannabinoid) system was discovered.
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PMC11754432
Western analysis (E) of total and phospho EGFR (Y1068) relative to control siRNA (N = 5).
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PMC11723947
d Percentage of CD73FR4 cells among WT or HP1γ KO TCR Vβ6 Tconv, as determined in the spleen 21 days after engraftment.
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PMC9429973
Furthermore, we find upregulation of proteins involved in endoplasmic reticulum (ER) stress to be significantly correlated to the CALR mutation burden across HSPCs, granulocytes, and T-cells.
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PMC11345828
As predicted, both 19 and 20 show similar binding affinity to Mcl-1 and inhibition of NCI-H929 cell growth to compound 18.
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PMC11757131
However, silencing the expression of the HIBCH gene using siRNA to reduce 3-HIB synthesis leads to a substantial decrease in cellular triglyceride synthesis (8).
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PMC2118063
The fact that AICDA transcripts were ∼37% of normal in B cells from the KO may explain why levels of switched Ig classes were close to normal in IRF8 mice (60).
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PMC9429973
A sub-analysis of 48 patients treated with 2 (3L) and 3 (4L) prior TKIs, categorized by resistance or intolerance to the last received TKI, was performed.
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PMC8009078
The potentiality of each molecule was adjudged through binding interaction, in-silico pharmacokinetic and MD simulation assessments.
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PMC9429973
F. Kallel, F. Kammoun, H. Ben Salah, L. Ghorbel, N. Toumi, M. Charfi, I. Ben Amor, I. Frikha, L. Khalifa, Y. Fakhfakh, O. Kassar, M. Medhafar, S. Hadiji, A. Khanfir, J. Daoued, M. Elloumi Clinical Hematology Department, Hedi Chaker Hospital; Radiotherapy Department; Oncology Department, Habib Bourguiba Hospital, Sfax, Tunisia Background: Relapsed and refractory Hodgkin lymphoma (RR-HL) challenges clinicians to devise treatment strategies that are effective and safe.
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PMC6892818
In all, 10,000 events were acquired on a Guava EasyCyte flow cytometer and results analysed using EasyCyte software (Millipore, Watford, UK).
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PMC11721587
The mean fluorescence intensity of the photobleached region was calculated using ImageJ software, and the un-photobleached region in the vicinity was used to correct the curve.
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PMC9429973
Aims: The aim of study was to analyze clinical and laboratory characteristics, course and outcome of Covid19 infection in patients with multiple myeloma.
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PMC11766332
Glycosylation influences pre- and postnatal brain development and synaptic plasticity, all processes that play a major role in neurodevelopment.
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PMC9429973
Based on data from MANIFEST Arm 3, the randomized, double-blind, active-control Phase 3 MANIFEST-2 study was initiated to further evaluate the safety and efficacy of pelabresib in combination with ruxolitinib in JAKi treatment-naïve pts with MF (NCT04603495).
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