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OTAR3088
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BioData-CellLine_annotated

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PMC9739791
A combination of flavins with Pt(IV) under blue-light low-dose irradiation showed cytotoxicity comparable to that of cisplatin on various cell lines, including prostate cancer PC-3 and PDT-resistant CAPAN-1.
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PMC9688728
The distribution of averaged F-ratios for the list of identified metabolites ranges from 10 to 1630 (Figure 4).
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PMC11473750
g Representative Western blot analysis for endogenous RNF121 after immunoprecipitation of endogenous MYCN in total cell lysates from MYCN amplified Kelly and SK-N-BE(2)-C cells.
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PMC10936243
So, it’s all cost” [D084]. “
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PMC10040136
Data are means ± SEM *p < 0.05; **p < 0.01 clinicopathologic features in 12 patients with GIST Proportion of MSC in clinical samples correlates with Imatinib resistance and prognosis.
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PMC11188874
Patient samples were obtained following Institutional Review Board approval and written informed consent in accordance with recognized ethical guidelines under the Declaration of Helsinki.
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PMC9429973
Further, myTcell assists with the diagnosis and treatment of pancytopenia and infections.
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PMC11474209
These blooms may be identified by three distinct features: the poisoning of freshwater and marine organisms, the lack of oxygen caused by a large amount of biomass, and the buildup of poisons in the food chain .
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PMC10938336
The following is the formula that was used to calculate the cell viability.
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PMC6114978
Horseradish peroxidase-conjugated secondary antibodies used for western blots were obtained from Santa Cruz Biotechnology (catalog# sc-2055, sc-2054, or sc-2033).
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PMC8481254
These results suggested that CA could suppress the enhanced O-GlcNAcylation caused by HG in liver cancer cells.
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PMC11026382
d The distribution of DHFR mutational effects in the TYMS Q33S background, color coding identical to (c).
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PMC11314247
After, 1 × 10 treated cells were treated with 800 μL of trypsin 0.05%, and 100 μL of annexin buffer 1X, 2 μL of propidium iodide, and 2 μL of annexin V were added.
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PMC11730320
Rare CNVs of size ≥1 kb were prioritized based on frequency, inheritance pattern, gene impact, and gene annotations: of 7 rare deletions and duplications that impacted the exon of a gene (including the untranslated region), all were inherited from either or both parents.
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PMC9429973
We included 16 pts in phase 1, 9 with AZA and 7 with LDAC.
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PMC11365427
After centrifugation, the supernatant was divided equally into aliquots.
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PMC11748335
In cases where a Roadmap sample matched multiple Hi-C datasets, we randomly selected one.
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PMC11777207
We next confirmed that the differences in DC migration were specific to DC-mediated chemokine migration and not a consequence of other cell types that express these molecules.
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PMC10870498
The abnormal function of KIF23 always results in the arrest of mitosis and the appearance of binuclear or multinucleated cells .
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PMC9429973
45 treatment-emergent adverse events (TEAE) occurred after the last dose of sutimlimab in 11 patients.
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PMC11599565
Although we did not address the physiological role of this cell type, it is very likely that those resident cells represent a kind of progenitor cells with strong neuronal features.
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PMC11640555
Following the development of hypoxia, despite the high ROS production, tumor cells survive in that tumor microenvironment acquiring cell resistance mechanisms and inhibiting the antioxidant system as those of SOD and catalase.
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PMC11765988
Key contributing factors include genetic predisposition, immunosuppressive treatment, and sarcoid-like reactions (SLRs) triggered by tumors; Granulomas form in sarcoidosis due to a cell-mediated immune response, which can also occur around tumor antigens, showing immunological overlap with lymphoma; Chronic inflammation and immune dysregulation drive both sarcoidosis and cancer risk, with macrophage polarization (M1/ M2 types) and cytokine elevations playing significant roles; SLRs are granulomas in cancer patients without systemic sarcoidosis, often triggered by cancer therapies or by cancer cells and their microenvironment, and may indicate an immune response to cancer; Shared genetic markers like microRNAs and HLA alleles link sarcoidosis and lymphoma, suggesting common immunological pathways; Risk factors like smoking, obesity, and certain infections (e.g., EBV, HIV for lymphoma, bacteria for sarcoidosis) influence disease development in each condition; Long-term use of corticosteroids and other immunosuppressants in sarcoidosis may increase lymphoma risk, necessitating close monitoring in treated patients.
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PMC11087055
In the PS and non-PS epiblast cells, the disruption of the Pk1-localization was identified not only in the ΔDEP-misexpressing cells, but also in neighbors; however, this study is not designed to provide insight into questions of cell autonomy.
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PMC9429973
This panel enables the inclusion of seven common HLA class I molecules and increases SNP coverage to 11 million (MAF > 0.01).
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PMC11617590
The Bio‐Rad protein assay kit used for protein quantification was purchased from Bio‐Rad (Hercules, CA, USA).
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PMC10582049
The identified subpopulation of ADH1B CAFs can be used not only for better understanding of mechanisms associated with LUAD aggressiveness but also for the development of novel predictive models.
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PMC9429973
Summary/Conclusion: To assess potential regional influence on respondent answers, results were separately described by geography.
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PMC4839679
n = 5 independent biological replicate experiments.
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PMC3035438
The ratio of the O.D. for human IgG relative to chicken IgM is indicated above the graphs for each selected clone.
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PMC11611077
Average cell area of CHO cells was not significantly different from those of EF1α3D5 and EF1α4E10 cells (N.S. p = 0.0865 and 0.9989 re CHO cells, Dunnett’s post hoc multiple comparison after one-way ANOVA).
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PMC10652261
The absence of the C= O stretching band at 1645.28 cm in the IR spectra of compounds 2a–l revealed that ring closure occurred efficiently.
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PMC8009078
A number of drug discovery approaches including molecular docking, molecular similarity, pharmacophore and artificial intelligence can be used to facilitate the drug discovery efforts for COVID-19 [4–6].
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PMC9786247
Maintenance medium was supplemented with 10% fetal bovine serum (FBS; Fisher Scientific; heat-inactivated (56 °C for 30 min)).
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PMC4277423
Eight hours later, supernatants were again removed and replaced with fresh DMEM plus 10% FBS.
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PMC9429973
No patient was positive on day 30 after HSCT, suggesting that it may not be useful, whether the DNA or cDNA sample is studied.
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PMC11700165
The cells were starved overnight and then activated with serum for 10 min at room temperature.
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PMC11317131
Less active integrase variants fail to perform enough recombination events to produce sufficient numbers of progeny and are drained away.
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PMC8956657
D Detailed hydrogen bonding mediating the MERS ORF4b Arg P0 at the Gly, Thr, Asp bonding pocket of IMPα2.
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PMC11786704
Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum and phosphate buffer saline (PBS) were provided by Gibco (Grand Island, NY, USA).
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PMC11495567
Activated RAS stimulates the MAPK pathway from RAF culminating in cell survival .
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PMC11588085
Using an mRNA stemness index developed by Malta et al. (37), which utilizes a machine-learning algorithm to extract transcriptomic signatures from various SC databases, we evaluated the stemness index in TCGA ovarian cancer patient samples.
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PMC11612315
This alleviation was also observed in the group with additional BCTC (0.5 μg) treatment, and no significant differences between the 20 μg exendin 20–29 + CAP and 0.5 μg BCTC + CAP groups were found.
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PMC7723249
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family.
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PMC11588085
We validate the stemness index by examining the mRNA stemness index by grade.
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PMC9817179
In short, our simulation suggests that when the overall fixation rate is fast compared with the dynamics of targeted interactions, fixation artifacts can be minimized even with unequal fixation rates in and out of puncta.
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PMC11628309
These tumors, being the most prevalent extracranial neoplasm in childhood, contribute substantially to mortality rates among children (Nakagawara et al., 2018).
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PMC8164677
More than 75% patients are diagnosed at stage III or IV (localized or regional) when the disease spreads to the abdominal cavity, and often associated with low survival rate as shown in Figure 1.4 Debulking surgery followed by platinum-based chemotherapy remains the main option, but unfortunately high recurrence (70%) and acquired drug resistance are frequent events.5 Unclear etiology is also a hurdle in the treatment of ovarian cancer.
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PMC11539788
Forty-eight hours after transfection, the cells were collected for further experiments.
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PMC9429973
One patient was on ATT (1.96 %), fifteen on azoles (30.61 %), fourteen on PPI/H2RB/Antacid (28.57 %), and none on antiepileptics.
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PMC10040136
6MSC activates the PI3K-AKT signaling pathway via TGF-β2 to promote drug resistance in GIST cells.
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PMC9429973
Thirty-seven died early (21%).
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PMC11407042
Using a sterilized inoculation loop to streak bacterial cells onto LB agar plates containing 50 μg/mL Gentamicin Sulfate from the stored vial.
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PMC9429973
R. Kharrat, O. Charef, R. Berred, A. Chabaane, S. Sammoud, M. Bchir, F. Ben Lakhal, S. Feki, W. Borgi, E. Gouider, A. Amouri, W. Ayed, H. Ben Neji, B. Meddeb clinical hematology; Laboratory Hematology, Aziza Othmana hospital; Laboratory of Histology and Cytogenetics, Institut Pasteur de Tunis, tunis, Tunisia Background: Although all the progress made in hematology in the last decades, the treatment of acute myeloblastic leukemia (AML) is still disappointing with long term survival which does not extend 40%.
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PMC10547921
Immuno-agonists activate non-specific immune responses when administered systemically, and, in severe cases, can trigger a deadly storm of cytokines.
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PMC11790599
Methamphetamine causes cytotoxicity by inducing macropinocytosis through the activation of Ras and Rac1 and lysosomal dysfunction in human neuroblastoma cells (Nara et al., 2012).
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PMC11541241
The CaMV viral re‐initiation factor transactivator/viroplasmin (TAV) could interact with the HEAT repeat domains of TOR1 and hijack TOR/S6K1 signalling to drive their replication.
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PMC10898159
In vitro, V654A mutation encoded by KIT exon 13 was intermediately sensitive to anlotinib.
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PMC11240571
143B and HT1080 cells grown to 70% confluence were washed twice with phosphate-buffered saline (PBS) and then grown in 25 mL serum-free Opti-MEM medium.
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PMC11180402
A Methylation status of the miR-129 promoter in 5637 cells treated with ISO at indicated concentrations was determined by MS-PCR.
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PMC9985266
Western blot assays showed that compared with untreated MRC-5 cells, IL-27 treatment inhibited the protein phosphorylation of ERK and p38 and increased the expression of the autophagy-related markers LC3 and Beclin1 (Additional file 1: Fig. S3B, C).
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PMC11684269
During the early stage of development, the T cells exhibit expression of both CD4 and CD8 and are termed double-positive T cells.
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PMC9429973
Results: The mean age of patients was 35.0± 8.5 (from 18 to 70) years and 55.6% were positive for antibody.
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PMC8633974
The data support the idea that although gRNA targeting conserved genomic regions of HIV-1 proviral DNA are generally more efficacious, the TatE locus is critical to viral replication.
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PMC9927933
Briefly, 6- to 8-week-old mice were anesthetized with isoflurane via a gas chamber.
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PMC5716223
d Each histogram represents the fusion rate of L6C5 myoblasts after 2 and 9 days in DM (9 days: NGF vs CTRL: 22.2% vs 6%, p < 0.05).
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PMC10582049
On the other hand, the expression of ELN, LAMA2, and DCN was increased (Fig. 5E).
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PMC10607604
BRCA mutations are found in 15% of patients with ovarian cancer and in ~25% of patients with HGSOC.
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PMC9817179
This is useful because different fixatives have been chosen for studying different types of structures.
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PMC11258145
Comparison of all obtained results, both physicochemical analyses of membrane models and biochemical results performed for cells in vitro, clearly indicates that the mechanism of curcumin toxicity is related to the localization of its molecules within lipid membranes, which, by changing their properties leads to disturbances in metabolic processes within cells, and consequently, their death.
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PMC10482220
Third, the G3BP BC domain, which contains an acidic region and the RasGAP binding sequences, can dominantly inhibit SG formation.
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PMC11718031
As shown in Fig. 7, CD-FortiCHO outperformed other basal media overall.
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PMC11695623
This study provides a new direction for the diagnosis and treatment of LUAD.
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PMC11489351
Scale bars represent 20 μm.
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PMC7812570
In this study, GPI-anchored m36.4, a single-domain antibody (nanobody) targeting the coreceptor-binding site of gp120, was constructed with a lentiviral vector.
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PMC11422497
The proliferative index of GIST-T1 and GIST-882 cells in vivo was assessed using Ki-67 staining in xenograft tumor samples.
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PMC9727330
Khalid Bassiouny helped in supervision and data analysis.
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PMC11194678
Fig. S5 shows the effect of overexpressed STAU1 WT or mutants on HTT Q72 aggregation in COS7 cells and the correlation of HTT Q72 aggregation with STAU1 levels.
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PMC11672142
Jurkat cells were reacted with media alone, 20 μM cisplatin, or 2 μM DefNEtTrp for 72 h. It was observed that both DefNEtTrp (2.25-fold) and cisplatin produce a higher substrate cleavage compared to the media alone control (Figure S24).
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PMC9429973
By definition, diagnosis is histological, immunocytochemical and molecular.
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PMC7039683
We then built a network using the best-match candidate transcription factors as nodes and linked the nodes using their putative target motifs as directional edges (from the regulating factor to its target motif, Figure 2—figure supplement 3).
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PMC11721096
The B16 melanoma cell lines were sourced from the Shanghai Cell Bank, Chinese Academy of Sciences (Shanghai, China).
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PMC9424261
Recent research has shown that ferroptosis is implicated in numerous human diseases and pathological processes, such as tumors , ischemia-reperfusion injury , renal damage , cardiomyopathy , blood diseases , and iron metabolism-related diseases .
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PMC10440586
Left, results from IDHwt gliomas.
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PMC10033453
Vaccinia-infected BHK-21 cells were transfected with plasmids encoding for full-length pVSV-MorV-G and pVSV-L, pVSV-N, pVSV-M, and pVSV-P genes as described by Lawson et al. Cell supernatant containing infectious VMG was collected and filtered through a 0.22-μm filter (MilliporeSigma, Burlington, MA, USA) to remove residual vaccinia virus.
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PMC11286266
To increase the proportion of intact, active N-ATF6α molecules reaching the Golgi, a genetic construct featured the TM and LD of ATF6α deliberately lacking S1P and S2P cleavage sites, and further strategically appended with an Avi-tag at the C-terminal, was engineered.
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PMC7342409
Five mice were found in each group.
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PMC11248911
In addition, APN can induce angiogenesis and is detected on angiogenic blood vessels surface as compared to normal ones.
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PMC9910796
Additionally, a small fraction of pEP84R colocalized with pp220 in peripheral inclusions close to the cell surface.
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PMC3931643
Blotting for total eIF4E was used as a control to confirm equal pulldown in the untreated and asTORi treated samples, and additional blotting of the total cell lysates confirmed inhibition of TORC1 and TORC2 substrate phosphorylation by asTORi.
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PMC7887261
False discovery rate (FDR) adjusted P-values indicate significant associations based on a fixed-effect meta-analysis.
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PMC11680562
Notably, these measured particle sizes were larger than the crystalline sizes determined through XRD, which were approximately ~ 8.8 nm.
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PMC11534377
The interest in combining 5-Aza with IR for NSCLC emerges from the urgent need for better therapies for this challenging disease, often diagnosed late with limited treatment options .
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PMC8658661
Promoter mutations have been identified as the most frequent genetic changes in HCC, with an overall incidence of about 30–60% .
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PMC11779605
IPA pathway result bar graph.
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PMC10253973
Since then, other Pt(II) compounds, such as 2 and 3 (Figure 1), have been developed for cancer treatment.
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PMC11306331
D Representative images from one representative experiment of 3 biological replicates showing 3xFUS condensate dissolution and formation when cycling between lit and dark states.
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PMC9370419
The results demonstrated that estradiol benzoate had an inhibition function of HBx.
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PMC9874064
Scale bar ​= ​50 ​μm.
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PMC11534377
The findings were validated by histological and bioluminescent imaging investigations, which highlighted the promise of 5-Aza therapy in the treatment of NSCLC.
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