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PMC10198699
Genetic information contained in HBM naturally occurs in such HBM, rather than being ‘entered in’ such HBM ‘by or for a responsible party’.
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PMC11365427
Fei et al. found dysregulation of plasma aspartate and threonine, as well as BM glutamate and carnitine, in MM patients.
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PMC5916734
However, the relative catalytic efficiency of this method in other mammalian cells is not so evident.
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PMC11536589
Overall, these results revealed that MGST1 decreased the sensitivity of PDAC cells to KRAS inhibitor MRTX1133 by ferroptosis inhibition.
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PMC10887351
In the last few years, evidence has supported the existence of a fourth controversial β-AR subtype in the human atrium, the β4-AR, which has been shown to be coupled to Gs-AC signaling .
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PMC11472639
Participants arrived at the laboratory in the morning or the afternoon, having avoided strenuous exercise for 24-h prior to the visit and following a ≥4-h fast.
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PMC11703992
Meanwhile, the “Monocle” (ver 2.26.0) was also utilized for the pseudo-time analysis.
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PMC11604768
Promoter architecture diversity is a delicate design consideration, as including too few varieties may inadvertently render the library insensitive to certain TFs, whereas including more increases the library diversity and subsequently the experimental scale necessary to obtain library coverage without a similar gain in information.
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PMC11483468
When conducting cell culture, we observed that cells expressing the GST-TAT-LPTS39 protein grew slowly compared to the untreated cells.
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PMC9341513
For clarity, proteins are not shown. (
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PMC8609870
The study was approved by the Second Affiliated Hospital of Hainan Medical College (2018R005-F01).
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PMC6892818
Untreated RCC cells (‘786-O’ in d) and normal cells (‘HRPT’ in e), respectively, were also included as background controls.
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PMC9429973
Aims: To evaluate the clinical characteristics, survival outcomes and prognosis of IgD myeloma patients in the era of novel therapy.
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PMC11352666
The Wilcoxon rank-sum test was utilized for CERES dependency score comparisons between EWS cells and all other cell types, given the nonparametric dataset.
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PMC6114978
The tissue microarray was constructed by arraying 1.0 mm cores taken from formalin fixed paraffin embedded tissue and assembled using a MTA-1 tissue arrayer from Beecher Instruments (Sun Prairie, WI) as previously described .
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PMC10745221
Uninduced, untransformed BL21 E. coli were cultured in 10 mL LB media overnight at 37°C, leaving a final OD600 of 1.29.
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PMC11772449
The results showed that Huh-7 liver cancer cell line and Hela human cervical cancer cell line were treated with different concentrations of two drugs combined with 5 μM Sora, respectively.
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PMC10759659
b ARID1A knockdown by siRNA in HepG2/2.2.15 cell line was confirmed by Western blotting.
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PMC10577955
Phytochemical characterization of Thymus capitatus recorded that the plant is rich in triterpenoids, flavonoids, and phenolic acids .
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PMC11694346
In contrast, cells pre-treated with NEM showed weaker fluorescence after BT-DNBS incubation.
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PMC10529414
Recently, numerous TFs dysregulated in cancer have been reported to be involved in various processes associated with cancer hallmarks, such as proliferation, invasion, migration, and apoptosis .
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PMC11711935
CCN1 (CYR61, cysteine‐rich 61) is a fibroblast‐derived paracrine mediator of melanogenesis, secreted under UVB irradiation.
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PMC11306019
These include GA, protocatechuic acid (PA), 3,4-dihydroxyphenylpropionic acid (DPA), caffeic acid (CA), (+)-catechin (CC), (−)‐epicatechin (EC), hydroxytyrosol (HT), 3,4-dihydroxyphenylacetic acid (DAA), gallic acid ethyl ester (GE), (−)‐gallocatechin (GC), (−)‐epigallocatechin (EGC), quercetin (QC), luteolin (LT), (−)-epicatechin-3-gallate (ECG), and epigallocatechin gallate (EGCG).
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PMC11733919
Normal and cancer cells were cultured in Dulbecco’s Modified Eagle’s medium (DMEM medium supplemented with 10% FBS, 100 U/mL penicillin, 0.1 mg/mL streptomycin, and 0.25 μg/mL amphotericin B, Corning, Tewksbury, MA, USA) in a cell culture incubator (in a humidified atmosphere containing 5% CO2 at 37 °C).
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PMC10502403
Vγ9Vδ2 T cells are an innate-like T cell population.
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PMC11673902
In view of this, Byun et al. developed a suspended microchannel resonator (SMR) with an integrated constriction device, which allowed for the combined measurement of the buoyant mass and transport time of cells in a microfluidic channel and was used to efficiently differentiate between different types of lung adenocarcinoma cells, including metastatic and non-metastatic cells.
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PMC11449273
Lysates were centrifuged at 10,000 x g for 25 min at 4°C and the supernatants were divided into 1 mL aliquots, snap frozen and stored at -80°C.
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PMC9429973
In multivariate analysis, detection of FLT3-ITD MRD in CR confers independent prognostic significance for relapse (hazard ratio, 4.00; P<0.001) and overall survival (hazard ratio 2.78; P<0.001).
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PMC9429973
In MF patients the OS was predicted by tMN therapy, HR1.44 [1.04-1.98]; but not surgery/observation, HR1.17 [0.94-1.46], or non-implicated therapy, HR1.25 [0.83-1.87](Fig 1b).
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PMC11407042
Note: A seeding density of 6 × 10–7×10 cells/cm is recommended.
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PMC8658661
It should also be noted that, in addition to epithelial cells, the liver includes Kupffer cells (~15% of the total liver cell population), stellate cells (~8–10%), and liver sinusoidal endothelial cells (~3%) (see Figure 1).
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PMC6222635
The standard solutions were prepared with glucose and mannose standard references using the same preparation method used for the sample solution.
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PMC10932641
In the nucleus, lncRNA regulates gene expression at the epigenetic and transcriptional levels, while in the cytoplasm, it regulates gene expression at the posttranscriptional and translational levels.
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PMC11661040
With the rise of bioinformatics technology, researchers began to focus on the impact of CGREF1 on tumor disease.
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PMC11680578
MTT assay was conducted to assess the impact of the experimental compounds on cell viability, following the methodology outlined by Loosdrecht et al. and Shukal et al. SKOV-3 human ovarian cancer cells were plated in 96-well plates at a concentration of 1 × 10 cells/well.
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PMC10999934
Around 80% of individuals will experience a recurrence within five years because of resistance to chemotherapy, despite initially responding well to platinum-based treatment.
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PMC6024716
p-values were determined using the Chi-square test.
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PMC9429973
M. C. Wichert, A. Niedermayer, S. Enzenmüller, K.-M. Debatin, L. H. Meyer, F. Seyfried Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany Background: Targeting anti-apoptotic BCL-2 family proteins by BH3-mimetics has become a promising treatment strategy in acute lymphoblastic leukemia (ALL).
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PMC11774112
The combination effect was analysed by CompuSyn software, which follows the median effect principle to determine the combination index (CI) value (C).
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PMC10748106
622; RN=−0.208; QLOO2=62.33 The values of the molecular descriptors considered in the QSAR model are listed in Table 7.
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PMC9429973
Results: A total of 483 patients with incident WM were identified during the study period, of which 23 patients initiated ibrutinib treatment (mean age: 71.8 years, females: 47.8%).
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PMC4659567
These drawbacks motivate bioinorganic chemists to development of complexes based on other, i.e. non-platinum, transition metals, which would offer wide range of anticancer efficacy and show reduced negative side effects.
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PMC9429973
Methods: 34 patients with newly diagnosed AML (excluded APL) were included in the study group (17 males and 17 females; median age: 50 years).
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PMC9429973
At data cutoff, treatment was ongoing in more than half (27 [56.3%]) of pts; the predominant reason for treatment discontinuation was physician’s decision (11 [22.9%]), mainly due to lack of efficacy.
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PMC10777969
The cytotoxicity of FCP23 and FCP26 was examined as previously described with the colorimetric assay of the Dojindo Cell Counting Kit-8 (CCK-8) (Sigma-Aldrich, St. Louis, MO, USA) .
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PMC10968586
Another important reason for concern is represented by OLE and HT context-dependent dual action as both antioxidant and pro-oxidant agents, since such a behavior may alter the efficacy of cancer treatment in unexplored ways.
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PMC11092382
A.DC. [
[ { "tags": [ "O", "O", "O" ], "tokens": [ "A.DC", ".", "[" ] } ]
PMC9429973
Josip Benčević, Slavonski Brod; Faculty of Dental Medicine and Health Osijek, University of Osijek Josip Juraj Strossmayer, Osijek; School of Medicine, University of Zagreb; Department of Hematology and coagulation, University Hospital Holy Spirit, Zagreb, Croatia Background: Hip and knee osteoarthritis (OA) affect approximately 10-15% of persons older than 60 years of age.
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PMC10932641
Quantitative real-time fluorescence polymerase chain reaction was used to detect the difference in lncRNA GPRC5D-AS1 expression in blank control group, negative control group, siGPRC5D-AS1 group and oeGPRC5D-AS1 group.
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PMC9429973
According to manufacturer, the scale of NAbs titer is 0-100%, with ≥30% considered as positive and ≥50% as clinically relevant viral inhibition.
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PMC4277423
Fluorescent intensity of DDAO was measured by FACS analysis using LSR II.
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PMC9429973
Patients are at high risk for infection due to neutropenia and treatment with immunosuppressive therapy (IST).
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PMC11787651
The dashed line denotes a fold change of 2 in either direction, whereas the horizontal line indicates the significance threshold (p < 0.05).
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PMC9429973
The catheter related thrombotic complications (CRTC) was recorded only in PICC (n=7; 17%), p 0,003.
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PMC11683240
F, α1AT (Uniprot: P01009-A1AT_HUMAN) was the main component of the active chromatographic subfractions 34_55_56 to 58.
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PMC11763111
2Overexpression of LLT1 preserve naive/stem phenotype of CAR-T cells.
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PMC9429973
The median International Prognostic Index (IPI) was 3 (range, 1-4).Most patients (16/26,61.5%) received bridging therapy before CAR T cell infusion.
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PMC10823017
By negatively regulating GSK-3β, the PI3K/Akt pathway imparts protein stability to c-Myc.
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PMC11803918
In the dark condition, exosomes and hybrid exosomes showed equivalent cytotoxicity against A375 melanoma cells, indicating the percentages of apoptotic tumor cells and PI dead tumor cells.
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PMC10713411
TRIB3 has been shown to respond to DNA repair and interact with a variety of DNA repair genes, including BRCA1 and ATM to regulate genome integrity .
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PMC7185206
ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors.
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PMC7917457
Animals were kept in individually ventilated cages under standard conditions (12-h light:dark, temperature- and humidity-controlled conditions) and received ad libitum access to water and food.
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PMC10253553
The median age at diagnosis was 57 years.
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PMC11711066
HASMCs cultured with AS‐IV (1 μM) in the presence of methyl‐piperidino‐pyrazole (MPP) (5 μM), an ERα‐specific antagonist, or 4‐[2‐phenyl‐5,7‐bis(trifluoromethyl)pyrazolo[1,5‐a]pyrimidin‐3‐yl]phenol (PHTPP) (10 μM), an ERβ‐specific antagonist.
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PMC11543885
Dilute the urea concentration to 1.5 M by adding 972.8 μL of 50 mM Triethylammonium bicarbonate (TEAB).
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PMC11047729
it leads to the development of APL.
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PMC9429973
Consequently, they showed undetectable baseline anti-SARS-CoV-2 Ig levels before CP therapy according to anti-SARS-CoV-2 nucleocapsid- and S1-RBD-specific total Ig tests.
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PMC10882807
Our study provided evidence for the underlying mechanism of hsa_circ_0005397 functions in the tumorigenesis of HCC, and shed light on the potential biomarkers and therapeutic targets for HCC.
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PMC10729469
Preclinical studies in autoimmune diseases indicate that antigen-specific Tregs could be more efficient by controlling pathological immune responses in a disease specific manner [69–73].
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PMC11730305
Liver cancer is not usually diagnosed in the early stages and treatment measures are not effective enough in the advanced stages of the disease.
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PMC9318744
Furthermore, endosomal proteases release the viral RNA genome into the host cell .
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PMC9479186
MTT assay was used to confirm that silencing of NDUFC1 inhibits cell proliferation of BEL-7404 cells and SK-HEP-1 cells. (
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PMC11683240
First and second, α1AT or solvent control were preincubated on CHO-K1 cells for 15 min at 37 °C and were either present in the medium during intoxication with PT or washed away prior to PT-intoxication.
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PMC11551844
Marslin et al. (2018) have identified flavonoids, terpenoids, thiamine, phenolic compounds and/or carbohydrates, soluble proteins, polyphenols, terpenes, vitamins, hydroxyl group, carboxylic acid and polypeptides, among others, in plants for the reduction of Au.
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PMC11310713
P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 versus OVX + GTB.
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PMC11742431
Due to differences in cell surface PD‐L1 expression levels, KVN and K14N proteins had the most significant effect on 5637 cells.
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PMC10870498
Red represents the genes associated with succinylation; C The levels of KIF23-succ in HTori3 and ATC cells (TPC1, 8305C, 8505C, BCPAP) were detected by Western blot; D Co-IP assay was used to screen the proteins associated with succinylation of KIF23 in HEK-293T cells; E Co-IP assay was used to detect the interaction between KIF23 and SIRT7 in HEK-293T cells; F Western blot was used to detect the levels of SIRT7, KIF23, and KIF23-succ after downregulation of SIRT7 in HEK-293T cells.
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PMC9429973
Methods: Thirty-one MDS and AML patients who had both bone marrow NGS and ctDNA at baseline were included for concordance analysis.
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PMC8735881
Previous studies suggested that GPI-anchored anti-gp120 scFv X5 (GPI-X5) and nanobody (GPI-m36.4) can interfere with the expression and processing of viral Env glycoproteins and the infectivity of progeny HIV-1virions, underlying a multifaceted mode of antiviral action .
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PMC7171147
Fig. 4COL11A1 upregulates fatty acid synthesis in ovarian cancer cells.a Real-time PCR of FASN in A2780cis-scrambled and A2780cis-shCOL11A1 and in ES2 cells co-cultured with CAF-scrambled or CAF-shCOL11A1.
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PMC11297139
Furthermore, Gene ontology (GO) analysis revealed that ARID1A LLPS-dependent upregulated genes are significantly enriched by cancer-related terms such as migration, adhesion, and angiogenesis, consistent with the previous experimental results (Fig. 4c).Fig.
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PMC11486946
The calculations were performed using a custom-made program written in Python 3.8.18.
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PMC11772585
Trizol was utilized for total RNA extraction, followed by reverse transcription using the PrimeScript RT reagent Kit (Takara Bio, Dalian, China) as per the manufacturer’s instructions.
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PMC10847511
After correction for multiple testing, 6 assays (Oxaliplatin 4, Cisplatin 1, and Carboplatin 1) remained statistically significant for positive correlations (adjusted P < 0.05).
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PMC11794847
FOXA2 is an important transcription factor in inducing T cells maturation and differentiation.
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PMC3019555
In summary, our work identifies an important, as of yet unrecognized, role of the microtubule cytoskeleton in repressing HIF-1α translation and provides compelling evidence that microtubules are actively involved in regulating protein translation.
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PMC6684588
Previous studies have identified several BMPs that bind follistatin under certain conditions.
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PMC11676674
The CBMN assay was carried out following the instructions by , and in accordance with the Organization for Economic Co-operation and Development (OECD No. 487) guideline for testing chemicals .
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PMC9429973
Image: Summary/Conclusion: Three quarters of JEs are men which shows a lack of equity of representation.
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PMC11476004
As the aetiopathogenesis, morphology and biological behaviour of tumours in dogs and humans are similar, comparative studies on mutations and the formation of a pathological phenotype in dogs can be crucial models in the diagnosis of human diseases .
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PMC10443665
MDR1 mRNA expression in CCRF-CEM/R cells in 48 h exposure to APS, tragacanthin, and bassorin. *
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PMC8358176
There was an enhancement in the TNFRSF10B expression level in SWCNT-treated cells (4.64 ± 0.41), but expression in MWCNT-treated cells (3.37 ± 0.12) was similar to that of the control cells (3.55 ± 0.32).
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PMC11490153
C. citratus EO was obtained from Giahessence (Gorgan, Iran).
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PMC9429973
The belamaf dose cohorts currently being evaluated are Cohort 1 (1.9 mg/kg Q3/4W), Cohort 2 (1.4 mg/kg Q6/8W), Cohort 3 (1.9 mg/kg Q6/8W), Cohort 4 (1.0 mg/kg Q3/4W), and Cohort 5 (1.4 mg/kg Q3/4W).
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PMC11564405
Correlations were analyzed by the chi-square test or Spearman correlation.
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PMC2118063
Gene arrays were used to quantitate transcripts in primary human tonsillar and peripheral blood B cell (PBB) subsets (Fig. 1 B).
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PMC11001582
Graph, n = 3 mice per genotype, one-way ANOVA, Tukey’s multiple comparison.
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PMC9878278
We further compared the protein expression of the phosphorylated IRF3 (p-IRF3) using western blot, and as expected there was a marked increase in the p-IRF3 in siControl treated cells at 48hpi (Figures 3E,F).
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PMC11657744
This reduction is consistent with previous reports that AurA levels fluctuate throughout the cell cycle.
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PMC5363531
Cells were treated with IC50 doses of single agents or of their combination: PEM did not affect cell migration and, in combination with dasatinib, the migratory inhibition was comparable with that of dasatinib alone.
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