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PMC11240571
Methods: Human osteosarcoma cell line 143B and human fibrosarcoma cell line HT1080 were utilized.
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PMC9341513
Details of publicly available data used for simulation input and validation are given in Supplemental Table S3 and Supplemental Methods.
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PMC9351137
The SRCAP and p400/Tip60 chromatin remodeling complexes in humans and the related Drosophila Tip60 complex belong to the evolutionary conserved INO80 family, whose main function is promoting the exchange of canonical histone H2A with the histone variant H2A in different eukaryotic species.
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PMC8389560
At present, the high-throughput screening method is actively used to search for effective methods of anticancer therapy and in our further studies it can be used to search for intracellular SeNP targets.
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PMC11755467
In sharp contrast the levels of the only pro-HIV-1 tested miRNA hsa-miR-132-3p were strongly and significantly reduced to 25% at day 4 p.i. (
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PMC11474209
Biosensors are an exciting alternative for effective on-site analysis and field-based characterization.
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PMC10158546
Proliferating ReN cells were dissociated with Accutase, pelleted, re-suspended in cold differentiation medium, mixed 1:1 with ice-cold Matrigel, and then diluted further 1:11 with cold differentiation medium (final Matrigel dilution of 1:12).
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PMC11707577
After 30 min of incubation the labeling was uniform on the tentacles and on the body column, indicating an initial absorption of the phage on the cell surface (Figure 8B).
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PMC8996378
Maintaining the efflux function of ABCB1 requires energy generated by ATP hydrolysis, which requires ATPase (Szollosi et al., 2018).
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PMC9429973
Publications were evaluated based on inclusion of the 5 cardinal features related to VOD/SOS diagnostic criteria (i.e., ascites, hepatomegaly, bilirubin ≥2 mg/dL, weight gain of ≥5%, and right upper quadrant [RUQ] pain) and changes in diagnostic features over time.
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PMC11779993
We further attempt to determine the possible cause of cell migration upon the exposure of SPEE in keratinocytes cells in the wound-healing process.
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PMC11753435
Target and peptide sequences were encoded by their respective encoders, producing target embeddings r1,…, rn, and peptide embeddings p1,…, pn.
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PMC8469018
Interestingly, simultaneous treatment with uridine (in both concentrations) did not revert the effect of teriflunomide on tested cells.
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PMC11310713
To confirm the degree of progression to hyperplasia in mammary glands after HRT, mammary glands were harvested from rats, fixed in 4% PFA, embedded in paraffin, and sectioned at a thickness of 6 μm.
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PMC2614415
Following treatment cells were harvested, fixed and stained with propidium iodide before analysis by Flow Cytometry.
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PMC10094712
Enhancement of mRNA expression of the gene encoding caspase-4 is known to be possible in two ways.
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PMC10243817
Cell culture data are expressed as the mean ± SEM and analyzed by 2-tailed paired or unpaired Student’s t test or 1-way ANOVA with the Tukey’s post hoc test.
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PMC11772585
Current treatment options for CSCC include surgery, radiotherapy, chemotherapy, drug therapy, and targeted therapy.
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PMC10652261
HRMS (m/z): [M + H] calcd for C25H28N4OS: 433.2057.
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PMC11621493
Thus, PLA2G4D overexpression increases TAG formation in the absence of DGAT activity.
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PMC10547921
These metabolites have a strong inhibitory effect on targeted Ag + cells and show similar dose-dependent antitumor activity in both HSC-2 and H1703 EGFR + xenotransplantation models.
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PMC11463018
The percentage of cells in each part was indicated. (
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PMC11476106
Cells connect their cytoskeleton to the ECM through receptors such as integrins, thereby generating biophysical forces (traction and compression) known as biotensegrity .
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PMC11591794
The staining was performed directly as live cell staining in accordance with the kit protocol and the cells were incubated at 37 °C for 30 min.
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PMC11686380
One section from each brain was examined for control (n = 3), KD#1 (n = 7), and KD#1 + GAP43R (n = 6).
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PMC11750161
Thus, we suggest that conformational changes in the serine and threonine residues of the C-terminal domain of GPCR play an important role in the downstream signaling pathway.
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PMC8903741
Following dilution, the cells were incubated for 2–3 weeks.
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PMC11752767
TCR-T has elicited intense investigation interest since CAR-T therapy failed to meet the need for most solid tumors .
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PMC11718817
After polarization of macrophages, cells were treated with 200 ng/mL LPS for 2 h and 10 µM nigericin for 1 h to activate the NLRP3 inflammasome.
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PMC7185206
In brief, 786–0 cells were treated with control, ADAM10, and/or ADAM17 siRNA.
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PMC11739504
Moreover, it has been reported that cancer, obesity, and schizophrenia are related to primary cilia, which act as a cellular antenna for numerous biological signaling pathways, such as the Hedgehog (Hh), Notch, PCP, and mechanosensing pathways.
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PMC11562028
It implies that as a potential drug, the Re-CDs have a good application basis for use and storage.
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PMC11745823
Interestingly, we also found through analysis of the TCGA database that HIF‐1α and RIT1 are positively correlated in glioma tissues (Figure 7F).
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PMC11700165
Whole cell lysates of COS-7 cells expressing IS = ITK-SYK, BS = BTK-SYK, and TS = TEL-SYK along with SLP-76.
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PMC11687663
Ultimately, cancerous cells cause damage to the tissues and cause damaged to sudden cell divisions that multiply in healthy body cells, organ dysfunction and even death may be the result of these injured tissues .
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PMC10877303
Table 4ParametersKihadanin BRobustaflavone3-beta-O-(trans-p-Coumaroyl)maslinic acidMolecular Weight486.51 g/mol538.46 g/mol618.84 g/molNum.
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PMC11682224
The overexpression of CHDIL has been associated with more aggressive tumor behavior and poorer prognosis in cutaneous squamous cell carcinoma.
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PMC8409415
Compared with the control ADC, CD70‐ADC significantly inhibited the growth of CD70‐positive A2780cisR, SKOV3, and SKOV3cisR cells.
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PMC11530949
The presence of four strong and four weak peaks indicated that the NPs were crystalline.
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PMC11656657
Overall, our findings indicate that a significant proportion of pediatric sarcomas express the GD2 antigen, although expression levels are highly variable.
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PMC9822769
This hydrolysis generates (albeit partially and transiently) a cationic complex that may be a suitable substrate for OCTs.
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PMC11721096
The CHO@hTYR cells were stored at 4 °C, and the same number of recombinant cells were taken to detect the relative tyrosinase activity every 24 h. Additionally, the activity of the CHO@hTYR stored for different numbers of days was detected to comprehensively evaluate the stability of the CHO@hTYR.
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PMC8873393
Unexpectedly, vast majority of protein-coding genes exhibit large changes in chromatin-associated nascent transcripts without corresponding changes in cytoplasmic mRNA levels.
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PMC10965680
In this study, we identified several important candidate genes related to immunity (DOCK8, IL1R1, and IL7).
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PMC6114978
Cell confluence and detachment activate the Hippo pathway, causing LATS1/2 to phosphorylate TAZ and YAP on several serines, including serine 89 on TAZ and serine 127 on YAP.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "confluence", "and", "detachment", "activate", "the", "Hippo", "pathway", ",", "causing", "LATS1/2", "to", "phosphorylate", "TAZ", "and", "YAP", "on", "several", "serines", ",", "including", "serine", "89", "on", "TAZ", "and", "serine", "127", "on", "YAP", "." ] } ]
PMC11687663
The passive membrane permeability of pharmaceuticals can be determined experimentally using the PAMPA, which involves quantifying the substances that have moved across a flat artificial membrane from donor to acceptor wells .
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PMC9429973
Aims: realMIND (NCT04981795) will assess real-world treatment patterns, effectiveness measures, and patient-reported outcomes among patients in the United States (US) with R/R DLBCL not receiving ASCT.
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PMC10728200
J The effect of STUB1 on the ubiquitination modification of the K191 site of GPX4.
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PMC8750422
Following an incubation of 24 h, cells penetrating the pores were stained with Diff-Quick staining solution (Sysmex, Kobe, Japan) and observed using a microscope.
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PMC11540664
Therefore, in this study, we aimed to investigate whether baseline lymphocyte counts could predict the probability of benefits from targeted immune combination therapy in patients with liver cancer.
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PMC11732523
Key: IVIG, intravenous immunoglobulin.
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PMC11791432
Survival analysis was performed using the Kaplan-Meier method , in which the log-rank P value was calculated .
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PMC10705095
These cells were transfected with the specified DNA and HBQ1 shRNA in a 6-well plate.
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PMC11786600
A single asterisk (*) represents p < 0.05, while a double asterisk (**) signifies p < 0.01 compared to the control group.
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PMC4369959
The inhibition of this tumor growth by 6-shogaol was associated with decrease in proliferation index (Ki-67) and increased apoptosis .
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PMC9429973
Aims: DREAMM-4 (NCT03848845) assessed safety and clinical activity of belamaf with pembrolizumab (pembro) in RRMM.
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PMC11549062
We applied two PDGFR inhibitors Sitravatinib (1 μM) and CP673451 (1 μM) to cells and found increased constrained diffusion (20.5% and 20.2%) and decreased directed diffusion (17.7% and 17.4%) of endosomes compared with control cells (18.6% confined and 21.3% directed).
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PMC9275501
A summary of the researches of carrier-free NDCDS used to co-deliver chemotherapy drugs and natural active ingredients is shown in Table 8.
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PMC10823017
The combination of BYL and ICA-1 showed a maximum decline in invasion with only a 76.2% reduction (P<0.001) in the number of invasive cells.
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PMC9429973
Results: Median time of asciminib treatment was 8.3 months (3.3–33.2) for the whole cohort.
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PMC3813807
No effective targeting therapy is available for gastric cancer, mainly due to a lack of complete understanding of the molecular mechanisms underlying gastric cancer development (3).
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PMC11747949
Interestingly, the CCR2 antagonist was effective at decreasing CXCL8 secretion by PBMCs only in normoxia.
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PMC9429973
Overall EPAG was well tolerated with no unexpected AEs.
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PMC11672881
Moreover, the upregulation of key oxidative-stress- and apoptosis-related genes, such as GPX3, CYP4F11, and HSPB8, provides insight into the molecular mechanisms underlying this combination’s effectiveness.
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PMC9429973
S. Khoduleva, D. Novik, D. Blizin, I. Novikova, A. Silin, I. Malishevskaya, A. Demidenko, I. Romashevskaya, E. Mitsura, L. Karataeva Hematology department, Gomel State University; Hematology department; Molecular Genetics Laboratory; Clinical Laboratory, Republican Research Center for Radiation Medicine and Human Ecology, GOMEL, Belarus Background: The risk of venous thrombosis in high-risk hereditary thrombophilia reaches 80%.
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PMC11247842
We chose the MR-MEGA approach to combine multi-trait results because this method showed higher power to detect association signals compared to METAL (results shown below).
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PMC8658661
In total, about 14,000 genes are expressed in HepG2 cells .
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PMC8009078
To dock the entire set of molecules through ADV, the Autodock tools (ADT) was used to prepare and convert all the molecules into.pdbqt format.
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PMC11711063
Rank order of extracellular matrix and adhesion molecules upregulated by ZG16B in HME‐hTert cells.
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PMC6450504
On P-gp overexpressing A2780-ADR cells (Figure 5(a)), coated and noncoated PEIPOS enhanced cytotoxicity when compared to free PTX in concentrations varying from 32 to 4 µM (Figure 5(b)).
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PMC11575040
A375 cells were transfected with miR-1270 mimics for 48 h, followed by Ago2 protein precipitation.
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PMC11766309
Targeting YKT6 could enhance autophagy regulation and improve therapeutic strategies for personalized cancer treatment.
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PMC11705901
The pGL3-basic vector only has the luciferase gene and it was ligated to different gene fragment as listed in Table 1.
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PMC9429973
It has been reported that, also due to psychological reasons, a fraction of patients delayed seeking medical attention after noticing symptoms.
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PMC11718274
These DNA fragments can readily diffuse within an agarose matrix, manifesting as a halo with a hazy outline.
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PMC11392912
Our results, therefore, suggest that, Clo-miR-14, abundantly present in Turmeric, has potential anti-inflammatory and anti-rheumatic effects, and also stable in processed food, resulting in significant amelioration of pro-inflammatory cytokines and arthritic score, can be considered as a potential miRNA-based drug candidate for RA.
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PMC11025866
VPA and VPM are the first examples of inhibitors of initial stages of lytic reactivation.
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PMC11420784
They antagonize autophagy initiation or autophagosomal maturation, evade autophagic recognition, or use components of the autophagy pathway to facilitate their intracellular survival [15–17].
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PMC7582629
The spectra/loadings of different components of the cells were converted into spatial distribution maps and translated into brightness pixels in the cell image.
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PMC11637716
In both patients, an EFL1:p.(Thr1069Ala) variant was present on the second allele.
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PMC11626627
Two different methods were used to process the tissues.
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PMC11502327
Therefore, all kinds of natural products have been widely used in nutritional supplements and treatment of inflammation, cancer, cardiovascular and other diseases (7, 8).
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PMC11684821
Unconventional T cells like intraepithelial lymphocytes (IELs), iNKT cells, γδ T cells,and a proportion of MAIT cells express CD8-αα (38, 39).
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PMC11585565
Means and standard deviations are indicated along the fitted decay lines. (
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PMC11172027
However, caspase-3 activity was not activated.
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PMC10530622
Oxidative stress was mitigated in the presence of N-Acetylcysteine, a known antioxidant and a GSH precursor, but a modest effect was observed in ER stress activation .
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PMC8164677
RPMI-1640 medium was used to culture cells (density of 4000–6000 cells/well) in 96-well culture plates.
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PMC10213199
Larvae group.
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PMC7724160
Table 3 shows the NMR metabolomics data for all reactors.
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PMC10607604
To determine whether these differences in sensitivity were due to differences in PTPN13 expression, we studied the effect of PTPN13 overexpression or silencing on chemotherapy sensitivity.
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PMC11803149
Meanwhile, we observed a slight increase in the proportions of Tex-like cells (clusters 3 and 4), cells differentiating to Tex (clusters 1 and 2), and cells lacking effector molecule expression (cluster5).
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PMC9512971
An important pharmacokinetic (PK) feature of camostat mesilate is that when orally administered, it is rapidly metabolized into an active metabolite (GBPA) by esterases [28–30].
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PMC7342409
According to the positive immunohistochemistry (IHC) results, Beclin 1 expression was highest in the imatinib group, followed by the imatinib-resistant group, and the combination group.
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PMC11387401
The stability of three (GAPDH, ACTB, and PLOD1) reference genes was verified with the geNorm method of Vandesompele et al, (2002) and the normalization factors were determined by the geometric mean of their relative quantities.
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PMC6461034
Cool to room temperature in ice/water.
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PMC11704834
Through its survival- and EMT-promoting gene regulatory programs, TLE1 may impact drug sensitivity and resistance in lung cancer cells.
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PMC11721096
The cytotoxicity was expressed as the percentage of cell viability compared with the blank control.
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PMC11607321
To reduce model complexity, MOSA only considers the most variable features as input for the encoders, while all features are reconstructed by the decoders for synthetic data generation, resulting in an asymmetrical design of VAE (Fig. 1b, Supplementary Fig. 2a, b, Supplementary Data 4).
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PMC10135767
After more than 1 h of treatment with 2% BSA, the slides were equipped to the flow chamber for subsequent experiments, and the functionalization of the flow chamber was finalized.
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PMC11726183
For BC therapy, in addition to chemotherapy and radiotherapy, new developments in chemotherapy alternatives have raised overall survival (OS) rates.
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