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OTAR3088
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BioData-CellLine_annotated

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PMC11777207
PD-L1 gMFI of VPD DCs in dLN. (
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PMC9964654
This complex has shown important therapeutic properties but exhibits poor solubility in water, like many other chemotherapeutic drugs.
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PMC8956657
HB number of hydrogen bonds, SB number of salt bridges, NHB number of non-hydrogen bonds generated in PDBsum, BSA buried surface area calculated in PISA.
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PMC11566417
Table 4Differentially expressed GO-terms from the proteomic analysis highlighted in Fig. 6bRefGO IDGO TermPrimary p10Immortal p10Primary p20Immortal p201GO:0007010Cytoskeleton organization7.3 × 101.4 × 107.8 × 108.8 × 102GO:0034330Cell junction organization3.5 × 101.6 × 10113GO:0048513Animal organ development1.2 × 1011.4 × 102.5 × 104GO:0097435Supramolecular fiber organization8.0 × 103.9 × 104.2 × 103.5 × 105GO:2000145Regulation of cell motility1.7 × 102.4 × 1013.4 × 10 Differentially expressed GO-terms from the proteomic analysis highlighted in Fig. 6b Our laboratory has been exploring the secretomes of stem and progenitor cells of various animals, including cows [15–17], horses and chickens .
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PMC10530622
One could expect that a dietary pattern such as the Mediterranean diet, with consistent effects on microbiota modulation, would increase SCFA production and decrease inflammation and maintain/increase species involved in oxalate metabolism, contributing to reducing the risk of lithiasis.
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PMC10114490
Next day, digested skin was vortexed for 20 s., centrifuged at 1500 g × 3 min and resuspended in 4 mL of incubation media (DMEM high glucose containing 20% fetal bovine serum and 1% penicillin–streptomycin).
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PMC11486946
By sorting with a 488 nm laser, cells exhibiting a higher fluorescence intensity than the autofluorescence measured beforehand were selected and isolated.
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PMC9436459
We hope that our newly proposed classification of natural MDAAs and summary of recent total synthetic investigations on them will provide a useful reference for researchers in natural products chemistry and organic synthesis.
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PMC10818573
These results show that positive fragments can be detected when the first reaction step is 5 min.
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PMC9429973
Exploratory analyses include assessing molecular response by sequencing cell-free DNA and Multiplexed ion beam imaging to analyze the tumor microenvironment.
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PMC11718809
A total of 18,905 circRNAs were identified in yak mammary tissues, and the differentially expressed circRNAs (DECs) may contribute to milk synthesis and composition regulation.
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PMC9954564
Moreover, vitiligo patients or control individuals with a history of autoimmune diseases were excluded from the study sample.
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PMC11525028
A recent study demonstrated that ac4C modification of mRNA plays a regulatory role in modulating mRNA stability.
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PMC10565698
The mixture was centrifuged (13000×g and 4 °C for 15 min) to obtain supernatant, which served as the cytoplasmic RNA sample.
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PMC10154097
The inhibitory activity of the miR-218-5p suppressor was assessed by qRT-PCR (Figure 4(d)).
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PMC6803987
On the 14th and 21st day of treatment, and P5, esculetin significantly reduced the enzyme activity of ALT and AST compared to the model group.
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PMC11718031
The underlying mechanism for this result remains unclear.
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PMC5311252
At the end of the experiment, altered relative abundances of miRNA-expressing populations between the three conditions (Ctrl0, Ctrl30 and Gef30) were evaluated by deep sequencing (Supplementary Table 1).
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PMC11661040
Conversely, overexpression of CGREF1 exerted an opposite effect.
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PMC11046454
To endow CAR-J with antigen-targeting capability, one end of the aptamer was labeled with an FITC moiety, termed as Apt.
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PMC10605143
Changes (MCF10A HSF1-pLVX versus MCF10A wild type) were considered significant if the signal ratios were >2.0 or <0.50 in both biological replicates.
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PMC9429973
The severity of the COVID-19 for vaccinated and unvaccinated patients were as follows, respectively,; Grade 1 (asymptomatic): 0 and 1, Grade 2 (mild symptoms, symptomatic therapy, no COVID19 specific therapy): 23 and 9, Grade 3 (mild symptoms, symptomatic therapy, with COVID19 specific therapy): 1 and 3, Grade 4 (moderate: pneumonia, thrombophlebitis, hospitalization): 2 and 3, Grade 5 (hospitalization requiring ICU, death): 0 and 1.
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PMC11680562
This makes the pectin-xanthan gum gel an ideal carrier for localized cervical cancer treatment, enhancing the delivery of CuO NPs and 5-Fu while minimizing side effects .
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PMC9429973
Two deaths were reported by the cut-off date (central nervous system hemorrhage [n=1; <3 mo]; intracranial hemorrhage [n=1; 3 to <6 mo]) that were not considered study drug related.
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PMC9429973
Because these are early data, the differences between arms in certain types of AEs or discontinuations due to AEs are difficult to interpret.
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PMC11533140
A logistic regression analysis showed a cytotoxicity ED50 value of 5.345 µM for compound 17p.
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PMC11708541
Aydoğmuş et al., established the involvement of K channels in the cell cycle by using 4-AP in conjunction with paclitaxel (PTX) (42) in MCF-7 and MDA MB-231 cell lines.
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PMC11750165
The yeast strain was transformed with pDBT-J2ICD as bait.
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PMC8068766
Kaplan–Meier survival analysis was performed by generating plots for each gene of interest by KM plotterMenyhart et al. (2018).
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PMC3681794
The 2 was calculated to represent the fold change of the target gene mRNA in hypoxia compared to normoxia .
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PMC11269933
The in vivo phosphorylation assay (J), in vivo PK activity assay (K–M) (n = 3; K), PA content ratio (n = 3; L) and ATP content ratio (n = 3; M) of HEK293T cells transfected with Flag-CgPk, Myc-CgErk1/2/Myc-CgErk1/2, and His-CgMap2k1/2.
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PMC11354239
Consistent with our findings, c-KIT was previously reported to correlate inversely with cytokine production by activated NK cells.
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PMC5311252
Even though we also detect E2F1 targeting, the overall analysis supports a powerful feed-forward loop through oncomotif-miRNA targeting of several TSs known to cause inhibition of E2F activity and G1/S progression.
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PMC10654497
Heatmap of SFRG expression in the two different subtypes. (
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PMC9429973
Baseline demographics were similar to those described on the licensing trial.
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PMC11768281
Circulating dendritic cells (DCs) and macrophages, functioning as APCs, patrol these areas, recognize Plasmodium antigens, and transport them for presentation to T cells .
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PMC9878278
SC grown to 60–70% confluency in a medium without penicillin–streptomycin were then transfected with 30 pmol of small interfering RNAs (siRNAs) using the Lipofectamine RNAiMax kit (Life Technologies).
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PMC11604015
Antigens limited to a subset of T cells may avoid severe fratricide and T cell aplasia; however, the appropriate tumor types must be carefully screened Fig. 2.
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PMC10530622
4-Hydroxyproline is catabolized into glycine via trans-4-hydroxy-L-proline oxidase or to glyoxylate via 4-hydroxy-2-oxoglutarate aldolase (HOGA).
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PMC9429973
L. K. Gjærde, L. H. Jakobsen, C. Juhl-Christensen, G. Olesen, I. Petruskevicius, M. T. Severinsen, C. W. Marcher, K. Theilgaard-Mönch, N. S. Andersen, L. S. Friis, B. Kornblit, S. L. Petersen, I. Schjødt, H. Sengeløv Department of Hematology, Rigshospitalet; Department of Clinical Medicine, University of Copenhagen, Copenhagen; Department of Hematology, Aalborg University Hospital; Department of Mathematical Sciences, Aalborg University, Aalborg; Department of Hematology, Aarhus University Hospital, Aarhus; Department of Hematology, Odense University Hospital, Odense, Denmark Background: Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment of acute myeloid leukemia (AML), but survival is challenged by the risk of relapse and treatment-related/non-relapse mortality (NRM).
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PMC10551595
Protein concentrations were determined using the Bradford assay.
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PMC10142392
Another promising result was also achieved by YH Bae and colleagues .
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PMC11564322
The data are expressed as means ± SD of three independent experiments, each of which consisted of six replicates per treatment group. *
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PMC11752740
Following combination treatment, NF-κB p65 expression in SK-BR3 cells was reduced by approximately 91%.
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PMC9966931
The possibility for the biotechnological production of these bio-based hybrid molecules was thus demonstrated, despite the fact that most of them have not previously been reported in nature.
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PMC6160470
Cancer stem cell (CSC) populations are regarded as one of the most resistant cell populations within a tumour and are postulated to be the main reason for cancer relapse.
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PMC9919300
Due to the increment of metabolic liver disease worldwide, by 2030, NAFLD/NASH are expected to be the most frequent reason for liver transplantation .
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PMC7570809
To our knowledge it represents the first peptide-based molecule reported in the literature able to specifically bind αvβ5 integrin and not cross react with αvβ3.
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PMC11509224
Specifically, regarding diterpenes, from 2009 to 2022, a total of 33 molecules were isolated from Agelas sponges, a number second only to those isolated from the genus Spongia.
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PMC11610461
KEGG gene sets, hallmark gene sets, and WikiPathways gene sets were downloaded for GSVA using the MSigDB database, and the results of relevancy analysis showed that PSENEN expression was positively related to oxidative phosphorylation (Fig. 4D).
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PMC11697065
Here, consistent with the data for volumetric titre analysis, mAb1- and BisAb2-expressing pools displayed the highest and lowest qP respectively (Fig. 1E).
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PMC7185206
linear regression model.
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PMC11322866
Absence of Lamin B1 in the nuclear envelope (1), diffused Lamin B1 around the nuclear envelope (2), and perinuclear Lamin B1 aggregates (3) were observed in senescent MM cells.
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PMC9429973
According to the current WHO classification (Table 1a) 28/34 large-cell morphology cases corresponded to double/triple hit (DH/TH) HGL because of additional BCL2 and/or BCL6-R and 6/34 were DLBCL NOS.
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PMC11568601
q-PCR was conducted with the following amplification program: 95 °C for 5 min, 10 s at 95 °C and 30 s at 60 °C for 40 cycles.
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PMC11655536
All statistical analyses were performed on GraphPadPrism 8 (GraphPadSoftware, La Jolla, CA, USA).
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PMC2196094
In addition, the RBL-1 cell line has previously been analyzed by Northern blots and found to be negative for mRNA encoding cathepsin G or a cathepsin G-like protease (data not shown).
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PMC10729469
Brain glucose hypometabolism is a prominent feature of AD.
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PMC10502403
The bar graph shows the average of five measurements of the mean fluorescence intensity (MFI) of MitoTracker Green and TMRM. (
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PMC11680049
Optical density was measured at a wavelength of 570 nm and a background wavelength of 620 nm using a multifunctional plate reader Spark 10M (Tecan, Männedorf, Switzerland).
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PMC11798926
For immunocytochemistry experiments, COS7 cells were used to better visualize intracellular organelles.
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PMC11025866
Strand-specific polyA-RNA libraries were prepared by the Illumina TruSeq stranded protocol.
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PMC9895440
The cell - lentiviral mixture was centrifuged for 90 min at 1000 g (spinfection) and the resuspended and plated for 24 h at 37 °C.
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PMC11727907
Then, secondary antibodies conjugated to Alexa Fluor 594 were used for 30 min at RT (1:400 in PBS) (Life Technologies Italia, Milan, Italy).
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PMC11752767
The development of CAR-T has gone through the inexhaustible efforts and exploration of several generations of scholars and can be roughly divided into five generations based on the number of intracellular domains and the number of transgenes in the CAR gene.
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PMC11496728
The optimized vectors were transfected into CHO-S cells, and the transient expression of eGFP was observed under fluorescence microscopy for 48 h, and the cell pellet was collected, and the MFI value of eGFP was detected by flow cytometry.
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PMC10933092
For instance, the expression of TRMT6/TRMT61A is significantly increased in hepatocellular carcinoma tissues and increased TRMT6 and TRMT61A levels are negatively associated with patient prognosis (Wang YY.
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PMC3035438
Antigen-specific chicken IgM and chimeric IgG were detected by ELISA using apoferritin-coated immunoplates incubated with the culture supernatant samples and with respectively anti-chicken IgM and anti-human IgG secondary antibodies.
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PMC9429973
Nowadays, no good biomarkers are available for this complication.
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PMC9429973
Before ARI0002h, daratumumab was identified in 10 pts (30.3%) and persisted even at day +100 in 5 of them (15.2%).
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PMC11683240
α1AT, α1-antitrypsin; qRT-PCR, quantitative reverse transcription PCR.
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PMC11718031
The viability in all other media is shown in Supplementary Fig. S1.
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PMC11075223
Tanaka inBull (distributed in Sichuan, Hubei of China), Cimicifuga simplex Wormsk. (
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PMC11637276
Similarly, α2 integrin inhibitors are being studied in clinical trials for solid tumours, either alone or in combination with chemotherapy .
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PMC8409415
As similar CD70‐ADCs have been reported to be tolerable in clinical trials, ours may also be safe.
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PMC11770130
In addition, the treatment of C22 ceramide, but not C16, indeed downregulated the expression of Gdf15 in the primary adipocytes (Fig. 6d; Supplementary information, Fig. S9f).
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PMC11443022
Deletions pattern in the azoospermia factor region was examined through polymerase chain reaction-sequence specific oligonucleotide method.
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PMC11593084
A five-week-old Sprague-Dawley rat (CLEA Japan, Tokyo, Japan) was immunized via intraperitoneal injection with LN229/PDPN (1 × 10 cells) in combination with Imject Alum (Thermo).
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PMC11509309
The screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of Verongiida sponges to prevent the propagation of prions.
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PMC5811757
These relapsing tumors often exhibit chemo-resistance towards several anti-cancer agents with various structures and mechanisms of action (3, 8).
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PMC9429973
Median dFLC was 265 mg/L (range 72-2966).
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PMC10778532
Cells were transfected using lipofectamine RNAiMAX transfection reagent (cat #13778-150, Invitrogen, Life Technologies Corp, San Francisco, CA, USA).
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PMC10938336
Moreover, the GO analysis unveiled potential regulatory functions of these genes, particularly in cancer cell proliferation through processes like identical protein binding and positive regulation of apoptotic processes.
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PMC11462929
Super‐enhancer activities of the N‐ME and BENC regions in the hockey stick plot indicating the rank order of the H3K27ac signal in NALM6. (
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PMC7057940
The Cytocell Aquarius kit was used, containing the EWSR1 Breakapart Probe (Cytocell, Ltd.), with a 392-kb red probe and a 631-kb green probe to be placed on either side of the EWSR1 gene.
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PMC11321678
So, low CG content value windows were filtered according to the distribution of CG content value of windows.
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PMC10158546
The faster PrP migration pattern could imply that the di-glycosylated form of PrP is lost upon differentiation, or alternatively might correspond to truncation of PrP. The increased PRNP RNA abundance, increased PrP protein abundance, and altered PrP migration pattern throughout ReN cell differentiation imply regulation of PrP at the transcriptional, translational, and post-translational levels, respectively.
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PMC11281366
The Vif-deficient (ΔVif) isogenic derivative was generated by inserting an SpeI (NEB, Ipswich, MA, USA, #R3133L) to SalI (NEB, #R3138L) fragment encompassing a vif deletion from the NL–PIvif-construct into NL4.3-ADA-GFP.
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PMC11467964
CCK‐8 reagent (New Cell & Molecular Biotech, China, C6005) was drawn into the 96 well plate, which was previously filled with SW982 and SYO‐1 cells (1000 cells/well) at intervals of 24, 48, 72, 96, and 120 h. Place the plate in cell culture incubator.
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PMC8735881
In regard to virus control, none of GPI-scFvs conferred resistance to vesicular stomatitis virus (VSV-G), indicating their antiviral specificity in transduced cells.
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PMC11394112
VAL-Luc cells also showed a similar pattern but occurred earlier (Figure 3D,E, right panels).
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PMC10253973
It is important in the HIV cell cycle to expose the influence of ligands on reactivity, as well as interaction with nucleic acids.
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PMC11640555
This was confirmed through analyses such as QPCR and R2 microarray (R2: microarray analysis and visualization platform) where primary samples from GBM patients were analysed, reporting high CK2α protein expression .
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PMC10778532
After incubation for 24 h, the non-migrating cells on top were scraped off and the membranes were fixed for 10 min in 70% ethanol solution and stained for 5–10 min with a solution of 0.2% crystal violet (Sigma-Aldrich St Louis, MO, USA).
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PMC9812014
It belongs to the Flaviviridae family, including the Zika virus, DENV, and yellow fever virus.
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PMC10587429
Allow HSCs to engraft for a minimum of 4 weeks.
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PMC9429973
Aims: We investigated the feasibility of the use of subtherapeutic doses in CML patients.
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PMC10142392
Star polymers offer opportunities for intelligent self-assembly design through synthetic manipulation of the composition of the branched polymeric structure, facilitating accumulation and absorption at the site of disease for increased biodisponibility and therapeutic effect.
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PMC11585254
The distal phospho-site cluster along the CT of the PTH1 receptor has more influence on the recruitment and binding of β-arrestin1 and β-arrestin2 than a more proximal cluster (Haider et al., 2022).
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PMC9964654
The antimicrobial activities of the BCMs and BCMs-Au(cdc)2 towards S. aureus Newman and the pathogenic fungi Candida glabrata CBS138 were assessed by the determination of minimum inhibitory concentrations (MICs) using microdilution assays, as previously described and according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) recommendations .
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