OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11594641	An equal amount of protein from cell lysates or an equal volume of sEVs resuspended in PBS was loaded onto 12% SDS-polyacrylamide gel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	One patient was AML and another relapsed with RAEB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "was", "AML", "and", "another", "relapsed", "with", "RAEB", "." ] } ]
PMC7192625	The AND-ChAs matrix shows the strong tendency for fragments with both H3K4me1 and H3K4me3 to interact preferentially and also for fragments with any of these two features and H3K27ac to interact preferentially.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673955	Levels of investigated genes expression were normalized relative to the expression of reference gene 18S.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Levels", "of", "investigated", "genes", "expression", "were", ...
PMC11700165	This is followed by recruitment and binding of SYK to the phosphorylated tyrosine (pY) on ITAM residues, and the activated SYK will subsequently phosphorylate downstream substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Scale bar: 100 µm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "µm", ".", "(" ] } ]
PMC11727062	A recent investigation has demonstrated that Evodiamine, functioning as a multi-targeted antiproliferative agent, selectively targets and suppresses the IRS4 as well as the downstream PI3K/AKT signaling cascade in vemurafenib-resistant melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	Koshkina et al. recently reported a method to visualize polymeric micelles using P MRI, indicating a growing interest in monitoring these systems in real‐time without the need for additional contrast agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11443022	Furthermore, seminiferous tubules were uniform, and mean Johnsen’s score count was 9.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "seminiferous", "tubules", "were", "uniform", ...
PMC9592219	However, our study has some limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "our", "study", "has", "some", "limitations", "." ] } ]
PMC11387401	We only detected three of these interactions in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "only", "detected", "three", "of", "these", "interactions", "in", "this", "study", "....
PMC8316344	These results demonstrated that TRIB2 declines TFRC expression in a way independent of PSMB5.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrated", "that", "TRIB2", "declines", "TFRC"...
PMC11499381	Initial experiments used CMB as a cell marker however due to shipping constraints DAPI was used in later experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initial", "experiments", "used", ...
PMC11474209	The generation of cyanotoxins in fishable, potable, and recreational water resources is the primary health risk brought on by cyanoHABs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gener...
PMC11206502	Comparisons of autophagosome signal ratios, compared to the positive control, were statistically significant at all tested HB concentrations (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11748618	Significant eQTLs (FDR < 0.05) from the combined population meta-analysis were filtered for functional HIV spVL associated SNPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "eQTLs", "(", ...
PMC11354239	However, very few studies have specifically addressed the role of c-KIT in NK cell function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "very", "few", "studies", "have", ...
PMC11045125	One month after retrovirus infection, protein extracts were harvested and immunoblot analysis was performed to assess expression levels of Myc, LMP1, and tubulin as indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486	Also, urine contains polypeptides with dityrosine in patients with diabetes undergoing HD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "urine", "contains", "polypeptides", "with", "dityrosine", "in"...
PMC11772449	However, whether p38γ is involved in the regulation of this process needs further study to reveal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "whether", "p38γ", "is", "in...
PMC11687167	ODYSSEY OUTCOMES2.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "ODYSSEY", "OUTCOMES2", "." ] } ]
PMC11707832	Their findings revealed significantly lower enzyme activity in the CSF of patients compared to healthy individuals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "findings", "revealed", "significantly", "lower", ...
PMC9325715	The spectrum of Fe-bLTF revealed a decrease in the 1129 cm band, which become almost undetectable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "spectrum", "of", "Fe-bLTF", "revealed", ...
PMC10936243	I think, it more depends on their lifestyle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", "think", ",", "it", "more", "depends", "on", "their", "lifestyle", "." ] } ]
PMC8469018	Teriflunomide did not change DHODH gene expression level as compared to the control (Figure 10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Teriflunomide", "did", "not", "change", "DHODH", ...
PMC11683240	The bar graph (B) shows the quantifications of Western blot signals from six independent experiments, while (C and D) show blots of representative experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11751675	This review focuses on the biosynthesis, structure–activity relationships, and biological activities of sesquiterpene lactones, with an emphasis on their antiviral potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11754291	Keratinocytes exposed to 50 mW/cm, 50 J/cm blue light (middle left) form smaller but well-organized colonies, consistent with blue light’s known effects of reducing keratinocyte proliferation and promoting differentiation (Castellano-Pellicena et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Statistical analysis have been made by using SPSS Statistics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "have", "been", "made", "by", "using", "SPSS", "Statistics", "." ] } ]
PMC8584319	Although eIF4E overexpression is common in malignant tumors , changes in its transcriptional or protein level have little effect on translation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "eIF4E", ...
PMC8345486	The incubation period, cell counts, and compound volume and concentration were established in an initial experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incubation", "period", ",", "ce...
PMC11541241	There has been a lot of progress in understanding M. oryzae TOR signalling (Li et al., 2023; Marroquin‐Guzman et al., 2017; Marroquin‐Guzman & Wilson, 2015; Sun et al., 2018, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718809	Figure 5A).	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Figure", "5A", ")", "." ] } ]
PMC11291490	DuPBMCs were seeded into a 96-well plate, 5×10 cells/well, and stimulated with 100 μg/mL inactivated TMUV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DuPBMCs", "were", "seeded", ...
PMC11773391	Briefly, A375 and SK‐MEL28 cells were treated with different concentrations of vMF (0.02 and 0.04 μM) and/or TMZ (0.3, 0.6, 0.9, 1.2, 1.5, 1.8 and 2.1 mM or 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 mM, respectively) for 24 h or 48 h (Figure 5A,B).	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	11 patients relapsed within the 1 year, and the median time from HSCT to relapse was 105 (83-184) days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC2777936	This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732523	RT-PCR revealed a high SARS-CoV-2 viral load, and mNGS of BALF identified Aspergillus spp.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-PCR", "revealed", "a", "high", "SARS-CoV-2", "viral...
PMC11363012	The availability of scRNA-seq data sets, which reveal how biosynthetic elements are expressed in specific cell types, is transforming how we elucidate and engineer plant-derived natural product pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Umbilical cords were collected from normal-term primipara fetuses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Umbilical", "cords", "were", "collected", "from", "normal-term", "primipara", "fetuses", "." ] } ]
PMC10976516	Increased tumor-infiltrating lymphocytes (TILs) with high Th1-related cytokine expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "tumor-infiltrating", "lymphocytes", "(", "TILs", ")", "with", "high", "Th1-rel...
PMC11640555	Additionally, 10 and 15 μM concentrations of CX-4945 significantly reduced CD34 expression levels, despite no significant changes observed after treatment with CX-4945 at the lower concentration of 5 μM. In GBM, the integrity of the primary tumor mass is influenced by intercellular structures as well as cell-to-cell adhesion, factors that may promote the progression of the tumor mass because of failure in tight junctions (TJs) to suppress cell proliferation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Importantly, GB5121 demonstrated rapid BTK inactivation kinetics (Kinact/Ki) in both peripheral and CNS tissues, a critical parameter for covalent irreversible inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9504875	Based on these results, we propose a model for antagonism of IFN production (Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "results", ",",...
PMC10606998	After completion of the reaction, the precipitate was collected with a magnet and washed with distilled water until the pH became neutral.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC9429973	W. Grey, A. Rio-Machin, P. Casado-Izquierdo, E. Gronroos, S. Ali, J. Miettinen, F. Bewicke-Copley, A. Parsons, C. Heckman, C. Swanton, P. Cutillas, J. Gribben, J. Fitzgibbon, D. Bonnet York Biomedical Research Institute, The University of York, York; The Francis Crick Institute; Bart’s Cancer Institute, London, United Kingdom; HiLIFE, Helsinki, Finland Background: Acute myeloid leukemia (AML) is an aggressive hematological disorder comprising a hierarchy of quiescent leukemic stem cells (LSCs) and proliferating blasts with limited self-renewal ability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	Reduced expression of SerpinA12 in psoriatic keratinocytes leads to increased expression of the interferon-inducible (56, 57) and psoriasis related inflammatory genes (chemokine ligand 20, IL-6, IL-8, and S100 proteins) (55).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	It can break target-RNA directed by gRNA with extremely high specificity and very low off-target effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "break", "target-RNA", "directed", "by", ...
PMC11551844	The cytotoxicity of JDE and JDH was due to the contribution of jaspamide and its analogs, and the presence of other secondary metabolites reported from the genus Jaspis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	In this figure, the daily energy costs of the homes that have PV systems are the negative values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "figure", ",", ...
PMC9777812	Of note, the mRNA expression of the CDKN1A gene was significantly decreased after transfection with bta-miR-106b mimics (Figure 3C; p < 0.01); at the same time, it was significantly increased in the bta-miR-106b inhibtor group (Figure 3D; p < 0.05), confirming the regulation of bta-miR-106b on CDKN1A expresion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: ERN-EuroBloodNet was conceived to contribute to innovative, efficient and sustainable health systems and facilitate access to better and safer healthcare for EU citizens while decreasing the cross-border health barriers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215722	In DSS-treated cells, a clear redistribution of Flot2 to fractions 2 and 3, and slightly also to fraction 4, was observed; the remaining gradient fractions also contained faint but definite protein bands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	Several strategies to activate Pt(IV) prodrugs by NIR and visible light have been attempted .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "strategies", "to", "activate", "Pt(IV", ")", "pr...
PMC8427838	Additionally, we stained mouse intestinal tissues for ezrin, which is highly expressed in intestinal epithelial cells and required for apical membrane organization .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Results: The median number of prior lines of systemic treatment was 1 (range 1-4), and all patients received a cytarabine-based regimen as first-line or second-line therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	These were described as either congruent or incongruent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "were", "described", "as", "either", "congruent", "or", "incongruent", "." ] } ]
PMC11615101	Exploring a less-studied biological sample or using a new technique for re-analysis can increase the possibility of finding novel biomolecules.46 Previously we identified a novel disease-associated protein, α-Taxilin, from SF cells, which was found to be upregulated in RA patients, suggesting their possible involvement in disease pathology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In part 2, patients received pembrolizumab + favezelimab at the established RP2D for up to 2 years (35 cycles), or until documented disease progression, adverse events (AEs), or withdrawal from study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We aimed to identify metabolic pathways regulating macrophages in the TME to improve macrophage effector cell function in lymphoma therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11637284	5000 copies each), which form a single large disk-shaped nucleoid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5000", "copies", "each", ")", ",", "which", "form", "a", "single", "large"...
PMC11521786	The images display autoradiography films corresponding to the detection of the molecules above mentioned in one representative experiment of two conducted for each cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10988808	B, D Representative immunoblots of biomarkers of the Hippo pathway, using ACTIN as reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "D", "Representative", "immunoblots", "of", ...
PMC11087055	Vg1-induced cell flow pattern under defective PS morphogenesis. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vg1-induced", "cell", "flow", "pattern", "under", "defective", "PS", "morphogenesis", ".", "(" ] } ]
PMC9429973	Between 2003 and 2021, we retrospectively included all patients 15 years old or older at diagnosis of STS, with pathogenic germline variant(s) in TRG, and at least one bone marrow assessment (bone marrow aspiration or biopsy).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Similarly, in the FGF5 locus, FGF5_E is a putative distal enhancer with increased ATAC-seq signal in Mes-like GC cell lines and TCGA-STAD relative to Epi-like and normal stomach, consistent with higher FGF5 expression in Mes-like GC cell lines and TCGA STAD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	We investigated the effects of a combination treatment on the SKOV-3 cell line both in vitro and using the CAM in vivo model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11577421	BSA+ was prepared by reacting native BSA (150 μM) with ethylenediamine (45 mM) in the presence of EDC (5 mM) in MES buffer (0.5 M, pH 4.8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	From these results, we infer that CCL19 promoted β2-integrin-mediated migration, which was inhibited in the presence of anti-β1 integrin antibodies and significantly reduced migration to below-baseline levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	Fig. 6HP1γ negatively controls immune checkpoint expression in effector Th cells.a Pattern of expression of genes overexpressed in Treg-exposed HP1γ KO Tconv compared with WT Tconv. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	The left subpanels display the distribution of IQRs (widths containing the 25th to 75th percentiles of contained CAGE signal) (A) and the number of TSSs with expression fraction ≥ 5% in 25% of samples (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	Additionally, SKCM cell lines with overexpression of MMP7, MMP11, and MMP14 showed altered sensitivity to a broad spectrum of anticancer drugs.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11423992	FACS was performed to assess TFAB002s’ binding ability with FcRn on H_FCGR2B CHO-K1 cells (A) at pH 6.0 and (B) at pH 7.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC6889484	p24 CA amounts were determined by using the HIV-1 p24 ELISA Kit (XpressBio, Frederick, MD, USA) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4816271	As expected the C-to-S mutant receptors were refractory to CID treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", "the", "C-to-S", "mutant", "receptors", "were", "refractory", "to", ...
PMC11574271	D The relative mRNA expression level of RON in bladder cancer cell lines was assessed using quantitative real-time polymerase chain reaction (qRT-PCR, with 5637 cells serving as the control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11627133	Normalized fluorescence profiles of SpyRho (orange, solid line) and GFP (green, dashed line) fluorescence along the dashed lines depicted in A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	The reaction was stopped by adding equal volume of 2× SDS loading buffer and boiled for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "was", "stopped...
PMC7039683	HOMER revealed 18 short sequences for which mPEAEs are enriched and that are present in at least 5% of them (Figure 5G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The most common Grade 3 or higher TEAEs were anemia (28%), febrile neutropenia (28%), platelet count decreased (24%), and hypokalemia (20%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	Although ROS at low levels might be beneficial by acting as physiological signaling regulators for normal homeostasis, excessive amounts of ROS can cause damage to lipids and eventual ferroptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	EMT is the key process involved in tumorigenesis; the vast majority of bladder tumors undergo EMT during tumor progression (Figure 3, Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To describe how Coronavirus Disease 2019 (COVID-19) affect patients with hematological malignancies treated with ASCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "describe", ...
PMC11768281	γδ T-cells, which account for approximately 4% of all T-cells in adult humans, are derived from a distinct progenitor that is neither CD4+ nor CD8+.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Extracellular vesicles (EVs) are nano-sized membranous structures secreted by all types of cells into the extracellular space.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extracellular", "vesicles", "(", ...
PMC11512230	It should be emphasized that under the experimental conditions, both SP uptake and adsorption may occur.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "should", "be", "emphasized", "that", ...
PMC11782780	The transcription factor EBF3 serves as a tumor repressor and is critical in tumor cell growth, proliferation, and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcription", ...
PMC11657695	A H3K4me3, H3K27ac and FLI1/ERG ChIP-seq data with quantitative value of peaks around KCNA2 promoter and sequences of EWS::FLI1 or EWS::ERG binding sites in A-673 (left panel), SK-N-MC (medium panel) and CHLA-25 (right panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC9780037	The protective effect of the 20 kDa PEG polymer was attained by excluded volume effect, which limited the interactions of cyt c with potentially denaturing molecules .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10454535	Human peripheral blood mononuclear cells were purchased from ATCC and cultured in Hank’s Balanced Salt Solution without Ca or Mg (ATCC) supplemented with 10% FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11206502	In BC cells, high basal and protective autophagy against anticancer treatments facilitates the avoidance of apoptotic cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "BC", "cells", ",", "h...
PMC11033180	REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesRabbit polyclonal anti-Sema5ANovus BiologicalsCat: NBP2-20291Rabbit polyclonal anti-Sema5AR&D SystemsRRID: AB_10641838; Cat:AF5896Rabbit polyclonal anti-Plexin A1AlomoneRRID: AB_2756765;Cat: APR-081Goat polyclonal anti-Plexin A2R&D SystemsRRID: AB_10573285;Cat: AF5486Rabbit monoclonal anti-synapsin 1Cell SignalingRRID: AB_2616578;Cat: 5297Mouse monoclonal anti-β3-tubulinSigma-AldrichRRID: AB_477590;Cat: T8660Rabbit polyclonal anti-phospho-synapsin 1(Ser62/67)Thermo Fisher ScientificCat: 11583501Rabbit polyclonal anti-phospho-synapsin 1 (Ser603)Thermo Fisher ScientificRRID: AB_560615;Cat: PA1-4604Rabbit polyclonal anti-phospho-synapsin 1 (Ser9)Cell SignalingCat: CST2311Rabbit polyclonal anti-p44/42 MAPK (Erk1/2)Cell SignalingRRID: AB_330744;Cat: 9102Rabbit polyclonal anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)Cell SignalingRRID:AB_331646;Cat: 9101Mouse monoclonal anti-CaMKII alphaInvitrogenRRID:AB_325403;Cat: MA1-048Rabbit monoclonal anti-phospho-CaMKII (Thr286) (D21E4)Cell SignalingRRID:AB_2713889;Cat: 12716Mouse monoclonal anti-β-ActinSigma-AldrichRRID:AB_476744;Cat: A5441Mouse monoclonal anti-β3-tubulin (β3-tubulin, clone 6G7)DSHBRRID:AB_2393086;Cat: clone 6G7Mouse monoclonal anti-S100β IgG1AbnovaCat: MAB12455Mouse monoclonal anti-nNOS type IBDRRID:AB_397700;Cat: 610308Rabbit polyclonal anti-ChAT (code PO3, Yeboah)Gift from Dr M. SchemannN/ARabbit Polyclonal anti-Calbindin D28KThermo Fisher ScientificRRID:AB_2792808;Cat: PA5-85669Human anti-HuGift from CHU of NantesN/AGoat polyclonal anti-HuC/D (N-15)Santa cruz Biotechnology, Inc.RRID:AB_2101223;Cat: sc5977HRP-conjugated goat polyclonal anti-rabbit IgG (H+L)Thermo scientificRRID:AB_228341;Cat: 31460HRP-conjugated rabbit polyclonal anti-mouse IgGSigma-AldrichRRID:AB_258431;Cat: A9044HRP-conjugated donkey polyclonal anti-goat IgGBethyl Laboratories, IncRRID:AB_66755;Cat: A50-101PCy3-conjugated donkey polyclonal anti-mouse IgG (H+L)Jackson ImmunoResearchRRID:AB_2315777;Cat: 715-165-151Cy3-conjugated donkey polyclonal anti-human IgG (H+L)Jackson ImmunoResearchRRID:AB_2340535;Cat: 709-165-149Cy3-conjugated donkey polyclonal anti-rabbit IgG (H+L)Jackson ImmunoResearchRRID:AB_2307443;Cat: 711-165-152FluoProbes 488 (Cy2) Donkey Anti-Goat IgG (H+L)InterchimCat: FP-SA2110FluoProbes 488 (Cy2) Donkey Anti-rabbit IgG (H+L)InterchimRRID:AB_2686906;Cat: FP-SA5110AMCA-conjugated Donkey Anti-Mouse IgG (H+L)Jackson ImmunoResearchRRID:AB_2340806;Cat: 715-155-150Chemicals, peptides, and recombinant proteinsLipofectamine 2000 reagentInvitrogenCat: 11668027Recombinant mouse semaphorin 5A-Fc ChimeraR&D systemsCat: 6584-S5-025Recombinant Mouse IgG2A FCR&D systemsCat: 4460-MG-100Matrigel Matrix Growth Factor ReducedCorningCat: 356231Recombinant Rat GDNF, CFR&D Systems - bio-techneCat: 512-GF-010/CFCollagen type I Rat tailCorningCat: 354236FM™ 1–43 DyeMolecular ProbesCat: T35356Clarity Western ECL SubstrateBio-RadCat: 1705061ProLong Gold Antifade ReagentsThermoFisher ScientificCat: P36930Critical commercial assaysQuikChange Lightning Site-Directed Mutagenesis KitAgilent TechnologiesCat: 210519Pierce BCA protein assay KitThermo Fisher ScientificCat: 23225Experimental models: Cell linesGreen monkey: COS-7 cellsATCCCat: CRL-1651;RRID:CVCL_0224Experimental models: Organisms/strainsRats Sprague-DawleyJanvier Labs, Le Genest Saint-Isle, FranceN/ARecombinant DNApcDNA3.0 -Sema5A-full-length(6xMyc C-terminal-tagged full-length rat Sema5A)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNA3.0 -Sema5A-FcRat extracellular domain of Sema5A (amino acid residues 1–961) fused at the C-terminus with a Fc fragment of human IgG (Sema5A-Fc)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNA3.0 -Fc(fragment Fc of human IgG)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNCA3.0 Sema5A-S951C-FcRat extracellular domain of Sema5A carrying ASD-associated mutation S951CThis paperN/ApcDNCA3.0 Sema5A-S956G-FcRat extracellular domain of Sema5A carrying ASD-associated mutation S956GThis paperN/ASoftware and algorithmsImage Lab software (v6.0.1)2017, Bio-Rad LaboratoriesRRID:SCR_014210Zen 2 softwareZeiss, GermanyRRID:SCR_013672Fiji softwareNIH, Open sourceRRID:SCR_002285https://fiji.scNIS-Element softwareNikon Instruments IncRRID:SCR_014329https://www.nikoninstruments.com/Products/SoftwareEasy Electrophysiology (v2.6.3)Easy Electrophysiology Ltd.RRID:SCR_021190https://www.easyelectrophysiology.com/GraphPad Prism 8GraphPad SoftwareRRID:SCR_002798https://www.graphpad.com/scientific-software/prism/PATCHMASTER softwareHEKA Instrument Inc.https://www.heka.com/downloads/downloads_main.html#down_patchmaster_nextOtherTranswell inserts 6.5 mm, 0.4 μm Pore Polyester membrane insertsCostarCat: 3450Ibidi 24-well platesibidi, Gräfelfing, GermanyCat: 82426 Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Hélène Boudin (helene.boudin@univ-nantes.fr).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	Proteins were transferred to a nitrocellulose blotting membrane (Amersham Protan 0.2 μm, GE Healthcare Life Sciences) and were blocked for an hour at room temperature by using TBS (10 mM Tris-HCL, 150 mM NaCl, 0.1% Triton X-100, and pH 8.0) buffer containing 5% skim milk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	These results suggest that eribulin can sequester tubulin dimers into assembling incompetent tubulin‒eribulin complexes at high concentrations, disturbing the extension of the primordial thread at the end of the microtubule at low concentrations, which can destabilize the microtubules or inhibit microtubule dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711127	S1, signal 1; S2, signal 2; S3, signal 3; S4, signal 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S1", ",", "signal", "1", ";...
PMC11788920	Although quantifying this process is complex, the P1 promoter is reported to regulate 85%–90% of c-Myc expression, with both NHE III1 and the c-Myc GQ playing significant roles in this regulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10820104	The crystal structure was deposited into the Cambridge Crystallographic Data Center (CCDC no. 2308479).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "crystal", "structure", "was", "deposited", "int...
PMC11361748	Examples of transfected cells are identified by asterisks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Examples", "of", "transfected", "cells", "are", "identified", "by", "asterisks", "." ] } ]
PMC9429973	There is lower risk of SPM and non-melanoma SPM in the acalabrutinib based regimens than the control arm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "lower", "risk", "of", ...
PMC9429973	72% were male.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "72", "%", "were", "male", "." ] } ]

PMC11594641

An equal amount of protein from cell lysates or an equal volume of sEVs resuspended in PBS was loaded onto 12% SDS-polyacrylamide gel.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

One patient was AML and another relapsed with RAEB.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "was", "AML", "and", "another", "relapsed", "with", "RAEB", "." ] } ]

PMC7192625

The AND-ChAs matrix shows the strong tendency for fragments with both H3K4me1 and H3K4me3 to interact preferentially and also for fragments with any of these two features and H3K27ac to interact preferentially.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5673955

Levels of investigated genes expression were normalized relative to the expression of reference gene 18S.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Levels", "of", "investigated", "genes", "expression", "were", ...

PMC11700165

This is followed by recruitment and binding of SYK to the phosphorylated tyrosine (pY) on ITAM residues, and the activated SYK will subsequently phosphorylate downstream substrates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11634027

Scale bar: 100 µm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "µm", ".", "(" ] } ]

PMC11727062

A recent investigation has demonstrated that Evodiamine, functioning as a multi-targeted antiproliferative agent, selectively targets and suppresses the IRS4 as well as the downstream PI3K/AKT signaling cascade in vemurafenib-resistant melanoma cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11604830

Koshkina et al. recently reported a method to visualize polymeric micelles using P MRI, indicating a growing interest in monitoring these systems in real‐time without the need for additional contrast agents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11443022

Furthermore, seminiferous tubules were uniform, and mean Johnsen’s score count was 9.0.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "seminiferous", "tubules", "were", "uniform", ...

PMC9592219

However, our study has some limitations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "our", "study", "has", "some", "limitations", "." ] } ]

PMC11387401

We only detected three of these interactions in this study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "only", "detected", "three", "of", "these", "interactions", "in", "this", "study", "....

PMC8316344

These results demonstrated that TRIB2 declines TFRC expression in a way independent of PSMB5.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrated", "that", "TRIB2", "declines", "TFRC"...

PMC11499381

Initial experiments used CMB as a cell marker however due to shipping constraints DAPI was used in later experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initial", "experiments", "used", ...

PMC11474209

The generation of cyanotoxins in fishable, potable, and recreational water resources is the primary health risk brought on by cyanoHABs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gener...

PMC11206502

Comparisons of autophagosome signal ratios, compared to the positive control, were statistically significant at all tested HB concentrations (p < 0.05).

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PMC11748618

Significant eQTLs (FDR < 0.05) from the combined population meta-analysis were filtered for functional HIV spVL associated SNPs.

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PMC11354239

However, very few studies have specifically addressed the role of c-KIT in NK cell function.

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PMC11045125

One month after retrovirus infection, protein extracts were harvested and immunoblot analysis was performed to assess expression levels of Myc, LMP1, and tubulin as indicated.

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PMC10452486

Also, urine contains polypeptides with dityrosine in patients with diabetes undergoing HD .

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PMC11772449

However, whether p38γ is involved in the regulation of this process needs further study to reveal.

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PMC11687167

ODYSSEY OUTCOMES2.

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PMC11707832

Their findings revealed significantly lower enzyme activity in the CSF of patients compared to healthy individuals .

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PMC9325715

The spectrum of Fe-bLTF revealed a decrease in the 1129 cm band, which become almost undetectable.

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PMC10936243

I think, it more depends on their lifestyle.

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PMC8469018

Teriflunomide did not change DHODH gene expression level as compared to the control (Figure 10).

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PMC11683240

The bar graph (B) shows the quantifications of Western blot signals from six independent experiments, while (C and D) show blots of representative experiments.

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PMC11751675

This review focuses on the biosynthesis, structure–activity relationships, and biological activities of sesquiterpene lactones, with an emphasis on their antiviral potential.

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PMC11754291

Keratinocytes exposed to 50 mW/cm, 50 J/cm blue light (middle left) form smaller but well-organized colonies, consistent with blue light’s known effects of reducing keratinocyte proliferation and promoting differentiation (Castellano-Pellicena et al., 2019).

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PMC9429973

Statistical analysis have been made by using SPSS Statistics.

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PMC8584319

Although eIF4E overexpression is common in malignant tumors , changes in its transcriptional or protein level have little effect on translation .

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PMC8345486

The incubation period, cell counts, and compound volume and concentration were established in an initial experiment.

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PMC11541241

There has been a lot of progress in understanding M. oryzae TOR signalling (Li et al., 2023; Marroquin‐Guzman et al., 2017; Marroquin‐Guzman & Wilson, 2015; Sun et al., 2018, 2019).

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PMC11718809

Figure 5A).

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PMC11291490

DuPBMCs were seeded into a 96-well plate, 5×10 cells/well, and stimulated with 100 μg/mL inactivated TMUV.

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PMC11773391

Briefly, A375 and SK‐MEL28 cells were treated with different concentrations of vMF (0.02 and 0.04 μM) and/or TMZ (0.3, 0.6, 0.9, 1.2, 1.5, 1.8 and 2.1 mM or 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 mM, respectively) for 24 h or 48 h (Figure 5A,B).

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PMC9429973

11 patients relapsed within the 1 year, and the median time from HSCT to relapse was 105 (83-184) days.

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PMC2777936

This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency.

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PMC11732523

RT-PCR revealed a high SARS-CoV-2 viral load, and mNGS of BALF identified Aspergillus spp.,

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PMC11363012

The availability of scRNA-seq data sets, which reveal how biosynthetic elements are expressed in specific cell types, is transforming how we elucidate and engineer plant-derived natural product pathways.

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PMC11588008

Umbilical cords were collected from normal-term primipara fetuses.

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PMC10976516

Increased tumor-infiltrating lymphocytes (TILs) with high Th1-related cytokine expression.

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PMC11640555

Additionally, 10 and 15 μM concentrations of CX-4945 significantly reduced CD34 expression levels, despite no significant changes observed after treatment with CX-4945 at the lower concentration of 5 μM. In GBM, the integrity of the primary tumor mass is influenced by intercellular structures as well as cell-to-cell adhesion, factors that may promote the progression of the tumor mass because of failure in tight junctions (TJs) to suppress cell proliferation .

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PMC9429973

Importantly, GB5121 demonstrated rapid BTK inactivation kinetics (Kinact/Ki) in both peripheral and CNS tissues, a critical parameter for covalent irreversible inhibitors.

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PMC9504875

Based on these results, we propose a model for antagonism of IFN production (Figure 7).

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PMC10606998

After completion of the reaction, the precipitate was collected with a magnet and washed with distilled water until the pH became neutral.

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PMC9429973

W. Grey, A. Rio-Machin, P. Casado-Izquierdo, E. Gronroos, S. Ali, J. Miettinen, F. Bewicke-Copley, A. Parsons, C. Heckman, C. Swanton, P. Cutillas, J. Gribben, J. Fitzgibbon, D. Bonnet York Biomedical Research Institute, The University of York, York; The Francis Crick Institute; Bart’s Cancer Institute, London, United Kingdom; HiLIFE, Helsinki, Finland Background: Acute myeloid leukemia (AML) is an aggressive hematological disorder comprising a hierarchy of quiescent leukemic stem cells (LSCs) and proliferating blasts with limited self-renewal ability.

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PMC11683130

Reduced expression of SerpinA12 in psoriatic keratinocytes leads to increased expression of the interferon-inducible (56, 57) and psoriasis related inflammatory genes (chemokine ligand 20, IL-6, IL-8, and S100 proteins) (55).

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PMC8922418

It can break target-RNA directed by gRNA with extremely high specificity and very low off-target effects.

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PMC11551844

The cytotoxicity of JDE and JDH was due to the contribution of jaspamide and its analogs, and the presence of other secondary metabolites reported from the genus Jaspis.

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PMC9622879

In this figure, the daily energy costs of the homes that have PV systems are the negative values.

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PMC9777812

Of note, the mRNA expression of the CDKN1A gene was significantly decreased after transfection with bta-miR-106b mimics (Figure 3C; p < 0.01); at the same time, it was significantly increased in the bta-miR-106b inhibtor group (Figure 3D; p < 0.05), confirming the regulation of bta-miR-106b on CDKN1A expresion.

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PMC9429973

Aims: ERN-EuroBloodNet was conceived to contribute to innovative, efficient and sustainable health systems and facilitate access to better and safer healthcare for EU citizens while decreasing the cross-border health barriers.

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PMC7215722

In DSS-treated cells, a clear redistribution of Flot2 to fractions 2 and 3, and slightly also to fraction 4, was observed; the remaining gradient fractions also contained faint but definite protein bands.

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PMC9739791

Several strategies to activate Pt(IV) prodrugs by NIR and visible light have been attempted .

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PMC8427838

Additionally, we stained mouse intestinal tissues for ezrin, which is highly expressed in intestinal epithelial cells and required for apical membrane organization .

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PMC9429973

Results: The median number of prior lines of systemic treatment was 1 (range 1-4), and all patients received a cytarabine-based regimen as first-line or second-line therapy.

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PMC11650848

These were described as either congruent or incongruent.

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PMC11615101

Exploring a less-studied biological sample or using a new technique for re-analysis can increase the possibility of finding novel biomolecules.46 Previously we identified a novel disease-associated protein, α-Taxilin, from SF cells, which was found to be upregulated in RA patients, suggesting their possible involvement in disease pathology.

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PMC9429973

In part 2, patients received pembrolizumab + favezelimab at the established RP2D for up to 2 years (35 cycles), or until documented disease progression, adverse events (AEs), or withdrawal from study.

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PMC9429973

Aims: We aimed to identify metabolic pathways regulating macrophages in the TME to improve macrophage effector cell function in lymphoma therapy.

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PMC11637284

5000 copies each), which form a single large disk-shaped nucleoid.

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PMC11521786

The images display autoradiography films corresponding to the detection of the molecules above mentioned in one representative experiment of two conducted for each cell line.

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PMC10988808

B, D Representative immunoblots of biomarkers of the Hippo pathway, using ACTIN as reference.

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PMC11087055

Vg1-induced cell flow pattern under defective PS morphogenesis. (

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PMC9429973

Between 2003 and 2021, we retrospectively included all patients 15 years old or older at diagnosis of STS, with pathogenic germline variant(s) in TRG, and at least one bone marrow assessment (bone marrow aspiration or biopsy).

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PMC11216402

Similarly, in the FGF5 locus, FGF5_E is a putative distal enhancer with increased ATAC-seq signal in Mes-like GC cell lines and TCGA-STAD relative to Epi-like and normal stomach, consistent with higher FGF5 expression in Mes-like GC cell lines and TCGA STAD.

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PMC11680578

We investigated the effects of a combination treatment on the SKOV-3 cell line both in vitro and using the CAM in vivo model.

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PMC11577421

BSA+ was prepared by reacting native BSA (150 μM) with ethylenediamine (45 mM) in the presence of EDC (5 mM) in MES buffer (0.5 M, pH 4.8).

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PMC11395280

From these results, we infer that CCL19 promoted β2-integrin-mediated migration, which was inhibited in the presence of anti-β1 integrin antibodies and significantly reduced migration to below-baseline levels.

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PMC11723947

Fig. 6HP1γ negatively controls immune checkpoint expression in effector Th cells.a Pattern of expression of genes overexpressed in Treg-exposed HP1γ KO Tconv compared with WT Tconv. (

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PMC9844987

The left subpanels display the distribution of IQRs (widths containing the 25th to 75th percentiles of contained CAGE signal) (A) and the number of TSSs with expression fraction ≥ 5% in 25% of samples (B).

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PMC11739484

Additionally, SKCM cell lines with overexpression of MMP7, MMP11, and MMP14 showed altered sensitivity to a broad spectrum of anticancer drugs.

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PMC11423992

FACS was performed to assess TFAB002s’ binding ability with FcRn on H_FCGR2B CHO-K1 cells (A) at pH 6.0 and (B) at pH 7.4.

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PMC6889484

p24 CA amounts were determined by using the HIV-1 p24 ELISA Kit (XpressBio, Frederick, MD, USA) according to the manufacturer’s instructions.

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PMC4816271

As expected the C-to-S mutant receptors were refractory to CID treatment.

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PMC11574271

D The relative mRNA expression level of RON in bladder cancer cell lines was assessed using quantitative real-time polymerase chain reaction (qRT-PCR, with 5637 cells serving as the control).

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PMC11627133

Normalized fluorescence profiles of SpyRho (orange, solid line) and GFP (green, dashed line) fluorescence along the dashed lines depicted in A).

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PMC11721587

The reaction was stopped by adding equal volume of 2× SDS loading buffer and boiled for 5 min.

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PMC7039683

HOMER revealed 18 short sequences for which mPEAEs are enriched and that are present in at least 5% of them (Figure 5G).

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PMC9429973

The most common Grade 3 or higher TEAEs were anemia (28%), febrile neutropenia (28%), platelet count decreased (24%), and hypokalemia (20%).

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PMC8316344

Although ROS at low levels might be beneficial by acting as physiological signaling regulators for normal homeostasis, excessive amounts of ROS can cause damage to lipids and eventual ferroptosis .

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PMC11755519

EMT is the key process involved in tumorigenesis; the vast majority of bladder tumors undergo EMT during tumor progression (Figure 3, Table 1).

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PMC9429973

Aims: To describe how Coronavirus Disease 2019 (COVID-19) affect patients with hematological malignancies treated with ASCT.

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PMC11768281

γδ T-cells, which account for approximately 4% of all T-cells in adult humans, are derived from a distinct progenitor that is neither CD4+ nor CD8+.

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PMC11755519

Extracellular vesicles (EVs) are nano-sized membranous structures secreted by all types of cells into the extracellular space.

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PMC11512230

It should be emphasized that under the experimental conditions, both SP uptake and adsorption may occur.

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PMC11782780

The transcription factor EBF3 serves as a tumor repressor and is critical in tumor cell growth, proliferation, and apoptosis.

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PMC11657695

A H3K4me3, H3K27ac and FLI1/ERG ChIP-seq data with quantitative value of peaks around KCNA2 promoter and sequences of EWS::FLI1 or EWS::ERG binding sites in A-673 (left panel), SK-N-MC (medium panel) and CHLA-25 (right panel).

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PMC9780037

The protective effect of the 20 kDa PEG polymer was attained by excluded volume effect, which limited the interactions of cyt c with potentially denaturing molecules .

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PMC10454535

Human peripheral blood mononuclear cells were purchased from ATCC and cultured in Hank’s Balanced Salt Solution without Ca or Mg (ATCC) supplemented with 10% FBS.

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PMC11206502

In BC cells, high basal and protective autophagy against anticancer treatments facilitates the avoidance of apoptotic cell death.

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PMC11033180

REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesRabbit polyclonal anti-Sema5ANovus BiologicalsCat: NBP2-20291Rabbit polyclonal anti-Sema5AR&D SystemsRRID: AB_10641838; Cat:AF5896Rabbit polyclonal anti-Plexin A1AlomoneRRID: AB_2756765;Cat: APR-081Goat polyclonal anti-Plexin A2R&D SystemsRRID: AB_10573285;Cat: AF5486Rabbit monoclonal anti-synapsin 1Cell SignalingRRID: AB_2616578;Cat: 5297Mouse monoclonal anti-β3-tubulinSigma-AldrichRRID: AB_477590;Cat: T8660Rabbit polyclonal anti-phospho-synapsin 1(Ser62/67)Thermo Fisher ScientificCat: 11583501Rabbit polyclonal anti-phospho-synapsin 1 (Ser603)Thermo Fisher ScientificRRID: AB_560615;Cat: PA1-4604Rabbit polyclonal anti-phospho-synapsin 1 (Ser9)Cell SignalingCat: CST2311Rabbit polyclonal anti-p44/42 MAPK (Erk1/2)Cell SignalingRRID: AB_330744;Cat: 9102Rabbit polyclonal anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)Cell SignalingRRID:AB_331646;Cat: 9101Mouse monoclonal anti-CaMKII alphaInvitrogenRRID:AB_325403;Cat: MA1-048Rabbit monoclonal anti-phospho-CaMKII (Thr286) (D21E4)Cell SignalingRRID:AB_2713889;Cat: 12716Mouse monoclonal anti-β-ActinSigma-AldrichRRID:AB_476744;Cat: A5441Mouse monoclonal anti-β3-tubulin (β3-tubulin, clone 6G7)DSHBRRID:AB_2393086;Cat: clone 6G7Mouse monoclonal anti-S100β IgG1AbnovaCat: MAB12455Mouse monoclonal anti-nNOS type IBDRRID:AB_397700;Cat: 610308Rabbit polyclonal anti-ChAT (code PO3, Yeboah)Gift from Dr M. SchemannN/ARabbit Polyclonal anti-Calbindin D28KThermo Fisher ScientificRRID:AB_2792808;Cat: PA5-85669Human anti-HuGift from CHU of NantesN/AGoat polyclonal anti-HuC/D (N-15)Santa cruz Biotechnology, Inc.RRID:AB_2101223;Cat: sc5977HRP-conjugated goat polyclonal anti-rabbit IgG (H+L)Thermo scientificRRID:AB_228341;Cat: 31460HRP-conjugated rabbit polyclonal anti-mouse IgGSigma-AldrichRRID:AB_258431;Cat: A9044HRP-conjugated donkey polyclonal anti-goat IgGBethyl Laboratories, IncRRID:AB_66755;Cat: A50-101PCy3-conjugated donkey polyclonal anti-mouse IgG (H+L)Jackson ImmunoResearchRRID:AB_2315777;Cat: 715-165-151Cy3-conjugated donkey polyclonal anti-human IgG (H+L)Jackson ImmunoResearchRRID:AB_2340535;Cat: 709-165-149Cy3-conjugated donkey polyclonal anti-rabbit IgG (H+L)Jackson ImmunoResearchRRID:AB_2307443;Cat: 711-165-152FluoProbes 488 (Cy2) Donkey Anti-Goat IgG (H+L)InterchimCat: FP-SA2110FluoProbes 488 (Cy2) Donkey Anti-rabbit IgG (H+L)InterchimRRID:AB_2686906;Cat: FP-SA5110AMCA-conjugated Donkey Anti-Mouse IgG (H+L)Jackson ImmunoResearchRRID:AB_2340806;Cat: 715-155-150Chemicals, peptides, and recombinant proteinsLipofectamine 2000 reagentInvitrogenCat: 11668027Recombinant mouse semaphorin 5A-Fc ChimeraR&D systemsCat: 6584-S5-025Recombinant Mouse IgG2A FCR&D systemsCat: 4460-MG-100Matrigel Matrix Growth Factor ReducedCorningCat: 356231Recombinant Rat GDNF, CFR&D Systems - bio-techneCat: 512-GF-010/CFCollagen type I Rat tailCorningCat: 354236FM™ 1–43 DyeMolecular ProbesCat: T35356Clarity Western ECL SubstrateBio-RadCat: 1705061ProLong Gold Antifade ReagentsThermoFisher ScientificCat: P36930Critical commercial assaysQuikChange Lightning Site-Directed Mutagenesis KitAgilent TechnologiesCat: 210519Pierce BCA protein assay KitThermo Fisher ScientificCat: 23225Experimental models: Cell linesGreen monkey: COS-7 cellsATCCCat: CRL-1651;RRID:CVCL_0224Experimental models: Organisms/strainsRats Sprague-DawleyJanvier Labs, Le Genest Saint-Isle, FranceN/ARecombinant DNApcDNA3.0 -Sema5A-full-length(6xMyc C-terminal-tagged full-length rat Sema5A)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNA3.0 -Sema5A-FcRat extracellular domain of Sema5A (amino acid residues 1–961) fused at the C-terminus with a Fc fragment of human IgG (Sema5A-Fc)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNA3.0 -Fc(fragment Fc of human IgG)Gift from A. Kolodkin (Johns Hopkins University, Baltimore, USAN/ApcDNCA3.0 Sema5A-S951C-FcRat extracellular domain of Sema5A carrying ASD-associated mutation S951CThis paperN/ApcDNCA3.0 Sema5A-S956G-FcRat extracellular domain of Sema5A carrying ASD-associated mutation S956GThis paperN/ASoftware and algorithmsImage Lab software (v6.0.1)2017, Bio-Rad LaboratoriesRRID:SCR_014210Zen 2 softwareZeiss, GermanyRRID:SCR_013672Fiji softwareNIH, Open sourceRRID:SCR_002285https://fiji.scNIS-Element softwareNikon Instruments IncRRID:SCR_014329https://www.nikoninstruments.com/Products/SoftwareEasy Electrophysiology (v2.6.3)Easy Electrophysiology Ltd.RRID:SCR_021190https://www.easyelectrophysiology.com/GraphPad Prism 8GraphPad SoftwareRRID:SCR_002798https://www.graphpad.com/scientific-software/prism/PATCHMASTER softwareHEKA Instrument Inc.https://www.heka.com/downloads/downloads_main.html#down_patchmaster_nextOtherTranswell inserts 6.5 mm, 0.4 μm Pore Polyester membrane insertsCostarCat: 3450Ibidi 24-well platesibidi, Gräfelfing, GermanyCat: 82426 Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Hélène Boudin (helene.boudin@univ-nantes.fr).

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PMC11129910

Proteins were transferred to a nitrocellulose blotting membrane (Amersham Protan 0.2 μm, GE Healthcare Life Sciences) and were blocked for an hour at room temperature by using TBS (10 mM Tris-HCL, 150 mM NaCl, 0.1% Triton X-100, and pH 8.0) buffer containing 5% skim milk.

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PMC10547921

These results suggest that eribulin can sequester tubulin dimers into assembling incompetent tubulin‒eribulin complexes at high concentrations, disturbing the extension of the primordial thread at the end of the microtubule at low concentrations, which can destabilize the microtubules or inhibit microtubule dynamics.

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PMC11711127

S1, signal 1; S2, signal 2; S3, signal 3; S4, signal 4.

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PMC11788920

Although quantifying this process is complex, the P1 promoter is reported to regulate 85%–90% of c-Myc expression, with both NHE III1 and the c-Myc GQ playing significant roles in this regulation .

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PMC10820104

The crystal structure was deposited into the Cambridge Crystallographic Data Center (CCDC no. 2308479).

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PMC11361748

Examples of transfected cells are identified by asterisks.

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PMC9429973

There is lower risk of SPM and non-melanoma SPM in the acalabrutinib based regimens than the control arm.

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PMC9429973

72% were male.

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