OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11739484	Understanding the molecular mechanisms underlying its progression and identifying reliable biomarkers is crucial for developing effective diagnostic and therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "molecular", "mechanisms", "underlying", "its", "progression", "and", "identifying", "reliable", "biomarkers", "is", "crucial", "for", "developing", "effective", "diagnostic", "and", "therapeutic", "strategies", "." ] } ]
PMC6650823	Highlighted by Rino Ragno Venetoclax (Ven ABT-199) is the first BCL-2 antagonist approved for Chronic Lymphocytic Leukemia (CLL), and Acute Myeloid Leukemia (AML) therapy in 2016.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Highlighted", "by", "Rino", "Ragno", "Venetoclax", "(", "Ven", "ABT-199", ")", "is", "the", "first", "BCL-2", "antagonist", "approved", "for", "Chronic", "Lymphocytic", "Leukemia", "(", "CLL", ")", ",", "and", "Acute", "Myeloid", "Leukemia", "(", "AML", ")", "therapy", "in", "2016", "." ] } ]
PMC11066331	Here we investigated five machine learning algorithms (k-nearest neighbors, decision tree, random forest, partial least squares discrimination, and artificial neural network) and optimized their performance either in pure populations or in two-component mixtures composed of cells with normal or silenced expression of TUSC3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "investigated", "five", "machine", "learning", "algorithms", "(", "k-nearest", "neighbors", ",", "decision", "tree", ",", "random", "forest", ",", "partial", "least", "squares", "discrimination", ",", "and", "artificial", "neural", "network", ")", "and", "optimized", "their", "performance", "either", "in", "pure", "populations", "or", "in", "two-component", "mixtures", "composed", "of", "cells", "with", "normal", "or", "silenced", "expression", "of", "TUSC3", "." ] } ]
PMC11301931	Ferroptosis is an iron-dependent form of cell death characterized by the peroxidation of membrane polyunsaturated fatty acids, leading to membrane damage and cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "is", "an", "iron-dependent", "form", "of", "cell", "death", "characterized", "by", "the", "peroxidation", "of", "membrane", "polyunsaturated", "fatty", "acids", ",", "leading", "to", "membrane", "damage", "and", "cell", "death", "." ] } ]
PMC11756907	Figure 4Cytotoxicity of the tested samples against 143B cells line expressed as % of cell viability ((A) results for GO; (B) results for GO-2ME vs 2ME; (C) results for RGO; (D) results for RGO-2ME vs 2ME).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4Cytotoxicity", "of", "the", "tested", "samples", "against", "143B", "cells", "line", "expressed", "as", "%", "of", "cell", "viability", "(", "(", "A", ")", "results", "for", "GO", ";", "(", "B", ")", "results", "for", "GO-2ME", "vs", "2ME", ";", "(", "C", ")", "results", "for", "RGO", ";", "(", "D", ")", "results", "for", "RGO-2ME", "vs", "2ME", ")", "." ] } ]
PMC11612794	S175 and T184 of CENP-T are labeled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S175", "and", "T184", "of", "CENP-T", "are", "labeled", "." ] } ]
PMC8728081	Thermal analysis was carried out with thermogravimetric analysis (TGA) attached with differential thermal analysis (DTA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thermal", "analysis", "was", "carried", "out", "with", "thermogravimetric", "analysis", "(", "TGA", ")", "attached", "with", "differential", "thermal", "analysis", "(", "DTA", ")", "." ] } ]
PMC9429973	R-CHOP and BR were the second most used regimen in 1L with decreased use in 2L+.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R-CHOP", "and", "BR", "were", "the", "second", "most", "used", "regimen", "in", "1L", "with", "decreased", "use", "in", "2L+", "." ] } ]
PMC8992508	These natural compounds are important constituents of human diet and are well known for their beneficial effects on health.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "natural", "compounds", "are", "important", "constituents", "of", "human", "diet", "and", "are", "well", "known", "for", "their", "beneficial", "effects", "on", "health", "." ] } ]
PMC10976516	NCT04495153ColoAd1, chimeric adenovirus strain (enadenotucirev)Ii.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NCT04495153ColoAd1", ",", "chimeric", "adenovirus", "strain", "(enadenotucirev)Ii.v", "." ] } ]
PMC10604092	Our novel cancer cachexia rat model is a promising tool to elucidate the pathogenesis of cancer cachexia and to conduct further research on the development of treatments and supportive care for patients with this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "novel", "cancer", "cachexia", "rat", "model", "is", "a", "promising", "tool", "to", "elucidate", "the", "pathogenesis", "of", "cancer", "cachexia", "and", "to", "conduct", "further", "research", "on", "the", "development", "of", "treatments", "and", "supportive", "care", "for", "patients", "with", "this", "disease", "." ] } ]
PMC11746948	Observation for lung metastatic tumor development three weeks later.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Observation", "for", "lung", "metastatic", "tumor", "development", "three", "weeks", "later", "." ] } ]
PMC11656657	p-value ≤ 0.05; p-value ≤ 0.01; p-value ≤ 0.001 and *** ≤ 0.0001 In vivo experiments of NSG mice bearing GD2 + sarcoma cells (RD, 143B or U-2OS) treated with NT or CAR.GD2 T-cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p-value", "≤", "0.05", ";", "", "", "p-value", "≤", "0.01", ";", "", "", "", "p-value", "≤", "0.001", "and", "", "", "", "*", "≤", "0.0001", "In", "vivo", "experiments", "of", "NSG", "mice", "bearing", "GD2", "+", "sarcoma", "cells", "(", "RD", ",", "143B", "or", "U-2OS", ")", "treated", "with", "NT", "or", "CAR.GD2", "T-cells", "." ] } ]
PMC10197932	However, a complete understanding of the effects of ultrasound on cells has not been achieved yet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "complete", "understanding", "of", "the", "effects", "of", "ultrasound", "on", "cells", "has", "not", "been", "achieved", "yet", "." ] } ]
PMC11481779	It can be easily distinguished from real data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "be", "easily", "distinguished", "from", "real", "data", "." ] } ]
PMC11075223	The identification methods of Cimicifugae Rhizoma including thin layer chromatography, microscopic identification, moisture, ash and impurity detection were described in ChP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "identification", "methods", "of", "Cimicifugae", "Rhizoma", "including", "thin", "layer", "chromatography", ",", "microscopic", "identification", ",", "moisture", ",", "ash", "and", "impurity", "detection", "were", "described", "in", "ChP", "." ] } ]
PMC11733919	Furthermore, cancer cells can adapt to oxidative stress by increasing the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) promoting tumorigenesis by the expression of numerous antioxidant proteins such as the regulators of GSH synthesis and metabolism, for example, GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "cancer", "cells", "can", "adapt", "to", "oxidative", "stress", "by", "increasing", "the", "activity", "of", "the", "transcription", "factor", "nuclear", "factor", "erythroid", "2-related", "factor", "2", "(", "NRF2", ")", "promoting", "tumorigenesis", "by", "the", "expression", "of", "numerous", "antioxidant", "proteins", "such", "as", "the", "regulators", "of", "GSH", "synthesis", "and", "metabolism", ",", "for", "example", ",", "GPX4", "." ] } ]
PMC11448304	Chen et al. identified 2011 Khib modified sites on 764 proteins in oral adenoid cystic carcinoma and deduced that Khib modifications promote cancer progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chen", "et", "al.", "identified", "2011", "Khib", "modified", "sites", "on", "764", "proteins", "in", "oral", "adenoid", "cystic", "carcinoma", "and", "deduced", "that", "Khib", "modifications", "promote", "cancer", "progression", "." ] } ]
PMC9985266	In lung epithelial and lung fibroblast cells, reduced autophagic pathways were found in patients with idiopathic pulmonary fibrosis (IPF) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "lung", "epithelial", "and", "lung", "fibroblast", "cells", ",", "reduced", "autophagic", "pathways", "were", "found", "in", "patients", "with", "idiopathic", "pulmonary", "fibrosis", "(", "IPF", ")", "." ] } ]
PMC9429973	All included patients had a previous AIHA history or developed/exacerbated AIHA during gestation or postpartum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "included", "patients", "had", "a", "previous", "AIHA", "history", "or", "developed/exacerbated", "AIHA", "during", "gestation", "or", "postpartum", "." ] } ]
PMC8592717	These have been widely used in the treatment of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "have", "been", "widely", "used", "in", "the", "treatment", "of", "cardiovascular", "(", "such", "as", "acute", "coronary", "syndrome", "and", "angina", "pectoris", ")", "and", "cerebrovascular", "diseases", "(", "such", "as", "stroke", ")", "in", "China", "for", "many", "years", "." ] } ]
PMC7090062	After treatment with RAPA, the miR-30 inhibitor also had no obvious influence on GIST cell viability in the context of IM intervention (Fig. 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "treatment", "with", "RAPA", ",", "the", "miR-30", "inhibitor", "also", "had", "no", "obvious", "influence", "on", "GIST", "cell", "viability", "in", "the", "context", "of", "IM", "intervention", "(", "Fig.", "5b", ")", "." ] } ]
PMC8481254	CA can inhibit the activation of the HBP pathway and reduce the expression of YAP and OGT under HG conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CA", "can", "inhibit", "the", "activation", "of", "the", "HBP", "pathway", "and", "reduce", "the", "expression", "of", "YAP", "and", "OGT", "under", "HG", "conditions", "." ] } ]
PMC11591794	The SRplot bioinformatics program was used to evaluate these data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SRplot", "bioinformatics", "program", "was", "used", "to", "evaluate", "these", "data", "." ] } ]
PMC11604830	These findings present a promising avenue for nanoparticle imaging in biomedical applications, offering potential enhancements to diagnostic and theranostic procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "present", "a", "promising", "avenue", "for", "nanoparticle", "imaging", "in", "biomedical", "applications", ",", "offering", "potential", "enhancements", "to", "diagnostic", "and", "theranostic", "procedures", "." ] } ]
PMC11687167	The mechanisms underlying these findings were related to the fact that the L-IFPTA + vaccine triggered functional anti-PCSK9 antibodies targeting circulating PCSK9, thereby reducing the plasma levels and activity of PCSK9 in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanisms", "underlying", "these", "findings", "were", "related", "to", "the", "fact", "that", "the", "L-IFPTA", "+", "vaccine", "triggered", "functional", "anti-PCSK9", "antibodies", "targeting", "circulating", "PCSK9", ",", "thereby", "reducing", "the", "plasma", "levels", "and", "activity", "of", "PCSK9", "in", "mice", "." ] } ]
PMC11244823	It had been obtained from a four-month-old foal from Iceland, whose data about health or vaccination were not available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "had", "been", "obtained", "from", "a", "four-month-old", "foal", "from", "Iceland", ",", "whose", "data", "about", "health", "or", "vaccination", "were", "not", "available", "." ] } ]
PMC11731614	We used the following antibodies on skin sections: K14 (BioLegend 906004).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "the", "following", "antibodies", "on", "skin", "sections", ":", "K14", "(", "BioLegend", "906004", ")", "." ] } ]
PMC11792888	Bar graph from Bax. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "graph", "from", "Bax", ".", "(" ] } ]
PMC9429973	In the analysis of Langenhorst et al. the optimal AUC was postulated to be 20 mg*h/l.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "analysis", "of", "Langenhorst", "et", "al.", "the", "optimal", "AUC", "was", "postulated", "to", "be", "20", "mg*h/l", "." ] } ]
PMC6468656	ACHN, A-498 and A-704 cells were maintained in MEM medium supplemented with 10% fetal bovine serum, penicillin (100 unit/mL), and streptomycin (100 μg/mL).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACHN", ",", "A-498", "and", "A-704", "cells", "were", "maintained", "in", "MEM", "medium", "supplemented", "with", "10", "%", "fetal", "bovine", "serum", ",", "penicillin", "(", "100", "unit/mL", ")", ",", "and", "streptomycin", "(", "100", "μg/mL", ")", "." ] } ]
PMC11799620	Table 1 presents the total phenolic amount of this extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1", "presents", "the", "total", "phenolic", "amount", "of", "this", "extract", "." ] } ]
PMC11001582	We also built DPR constructs in the patient range, comprising 400 uninterrupted polyGR or polyPR repeats, to replicate patient DPRs as closely as possible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "built", "DPR", "constructs", "in", "the", "patient", "range", ",", "comprising", "400", "uninterrupted", "polyGR", "or", "polyPR", "repeats", ",", "to", "replicate", "patient", "DPRs", "as", "closely", "as", "possible", "." ] } ]
PMC9429973	TP53 pathogenic variants were present in 26% of cases and were associated with a significantly inferior event free and overall survival compared to those without a TP53 abnormality: 45,3% (95%CI = 21-69,6%) vs 97,9% (95%CI=93,9-100%) (p < 0.001) and 47,1% (95%CI=21,8-72,4%) vs 97,9% (95%CI= 93,9-100%) respectively (p = 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TP53", "pathogenic", "variants", "were", "present", "in", "26", "%", "of", "cases", "and", "were", "associated", "with", "a", "significantly", "inferior", "event", "free", "and", "overall", "survival", "compared", "to", "those", "without", "a", "TP53", "abnormality", ":", "45,3", "%", "(", "95%CI", "=", "21", "-", "69,6", "%", ")", "vs", "97,9", "%", "(", "95%CI=93,9", "-", "100", "%", ")", "(", "p", "<", "0.001", ")", "and", "47,1", "%", "(", "95%CI=21,8", "-", "72,4", "%", ")", "vs", "97,9", "%", "(", "95%CI=", "93,9", "-", "100", "%", ")", "respectively", "(", "p", "=", "0.001", ")", "." ] } ]
PMC8143558	Soaps enhance the removal of microorganisms and dirt from body and other surfaces because they denature the microorganisms and emulsify the dirt thus performing a dual role of disinfection and cleaning.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Soaps", "enhance", "the", "removal", "of", "microorganisms", "and", "dirt", "from", "body", "and", "other", "surfaces", "because", "they", "denature", "the", "microorganisms", "and", "emulsify", "the", "dirt", "thus", "performing", "a", "dual", "role", "of", "disinfection", "and", "cleaning", "." ] } ]
PMC6461034	AXL, inactive in parental cells (see Appendix Fig S8), but associated with erlotinib resistance in this subline, can only be analyzed through the kinase‐centric arm (pink bar highlighting).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AXL", ",", "inactive", "in", "parental", "cells", "(", "see", "Appendix", "Fig", "S8", ")", ",", "but", "associated", "with", "erlotinib", "resistance", "in", "this", "subline", ",", "can", "only", "be", "analyzed", "through", "the", "kinase‐centric", "arm", "(", "pink", "bar", "highlighting", ")", "." ] } ]
PMC10932641	Long noncoding RNA (lncRNA) GPRC5D-AS1 can serve as a biomarker in clinical applications and the prognosis of lung squamous cell carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long", "noncoding", "RNA", "(", "lncRNA", ")", "GPRC5D-AS1", "can", "serve", "as", "a", "biomarker", "in", "clinical", "applications", "and", "the", "prognosis", "of", "lung", "squamous", "cell", "carcinoma", "." ] } ]
PMC11453853	We propose that abnormal growth factor signaling in breast cancer cells permits PR/ER complex formation which promotes expression of genes that induce endocrine resistance and CSC expansion through regulation of super enhancer elements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "propose", "that", "abnormal", "growth", "factor", "signaling", "in", "breast", "cancer", "cells", "permits", "PR/ER", "complex", "formation", "which", "promotes", "expression", "of", "genes", "that", "induce", "endocrine", "resistance", "and", "CSC", "expansion", "through", "regulation", "of", "super", "enhancer", "elements", "." ] } ]
PMC11769516	This effect was not observed after exposure to α-ZEL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "not", "observed", "after", "exposure", "to", "α-ZEL", "." ] } ]
PMC11591038	The major pathological characteristics of Alzheimer’s disease (AD) include senile plaques and neurofibrillary tangles (NFTs), which are mainly composed of aggregated amyloid-beta (Aβ) peptide and hyperphosphorylated tau protein, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "major", "pathological", "characteristics", "of", "Alzheimer", "’s", "disease", "(", "AD", ")", "include", "senile", "plaques", "and", "neurofibrillary", "tangles", "(", "NFTs", ")", ",", "which", "are", "mainly", "composed", "of", "aggregated", "amyloid-beta", "(", "Aβ", ")", "peptide", "and", "hyperphosphorylated", "tau", "protein", ",", "respectively", "." ] } ]
PMC6600253	In general, there are three typical strategies for TIS that can be considered: (i) the activation of DDR-related senescence by radiation or genotoxic chemotherapeutics, (ii) the reactivation of senescence-mediated tumor suppressor genes, and (iii) the induction of cytokine-induced senescence (CIS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "there", "are", "three", "typical", "strategies", "for", "TIS", "that", "can", "be", "considered", ":", "(", "i", ")", "the", "activation", "of", "DDR-related", "senescence", "by", "radiation", "or", "genotoxic", "chemotherapeutics", ",", "(", "ii", ")", "the", "reactivation", "of", "senescence-mediated", "tumor", "suppressor", "genes", ",", "and", "(", "iii", ")", "the", "induction", "of", "cytokine-induced", "senescence", "(", "CIS", ")", "." ] } ]
PMC11537649	The transfection efficiency was confirmed by qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transfection", "efficiency", "was", "confirmed", "by", "qRT-PCR", "." ] } ]
PMC11126803	We generated luciferase stably transfected A498 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "generated", "luciferase", "stably", "transfected", "A498", "cells", "." ] } ]
PMC9429973	All patients have indication for systemic therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "have", "indication", "for", "systemic", "therapy", "." ] } ]
PMC7759933	The qPCR experiments were performed on 48.48 Dynamic Array™ IFC chips for gene expression on the BioMark HD machine system (Fluidigm, UK) and data were analysed with an open web program QuantGenious .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "qPCR", "experiments", "were", "performed", "on", "48.48", "Dynamic", "Array", "™", "IFC", "chips", "for", "gene", "expression", "on", "the", "BioMark", "HD", "machine", "system", "(", "Fluidigm", ",", "UK", ")", "and", "data", "were", "analysed", "with", "an", "open", "web", "program", "QuantGenious", "." ] } ]
PMC11748335	A previous study has reported that broad H3K27me3 regions are enriched for oncogenes (OGs), but the influence of different DNA methylation backgrounds was not considered .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "previous", "study", "has", "reported", "that", "broad", "H3K27me3", "regions", "are", "enriched", "for", "oncogenes", "(", "OGs", ")", ",", "but", "the", "influence", "of", "different", "DNA", "methylation", "backgrounds", "was", "not", "considered", "." ] } ]
PMC11269792	GeTu ZhaoRi and ChunJuan Wang designed the research study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GeTu", "ZhaoRi", "and", "ChunJuan", "Wang", "designed", "the", "research", "study", "." ] } ]
PMC9429973	Among 188 BAT LOTs with agent-level data available, most common treatments were midostaurin (53%) and cladribine (24%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "188", "BAT", "LOTs", "with", "agent-level", "data", "available", ",", "most", "common", "treatments", "were", "midostaurin", "(", "53", "%", ")", "and", "cladribine", "(", "24", "%", ")", "." ] } ]
PMC10728200	Significance denoted by: ns not significant, P < 0.05, P < 0.01, and **P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significance", "denoted", "by", ":", "ns", "not", "significant", ",", "", "P", "<", "0.05", ",", "", "", "P", "<", "0.01", ",", "and", "", "", "", "P", "<", "0.001", "." ] } ]
PMC4277423	The downloaded sequence was used to build a bowtie reference database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "downloaded", "sequence", "was", "used", "to", "build", "a", "bowtie", "reference", "database", "." ] } ]
PMC9884169	Ferroptosis is a form of programmed cell death different from apoptosis and necrosis [7–9].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "is", "a", "form", "of", "programmed", "cell", "death", "different", "from", "apoptosis", "and", "necrosis", "[", "7–9", "]", "." ] } ]
PMC9243326	In an alcohol-induced liver injury model, the significant antioxidant and hepatoprotective activity of C. chinensis polysaccharide (CCPS) was demonstrated (Jiang et al., 2013; Fan et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "an", "alcohol-induced", "liver", "injury", "model", ",", "the", "significant", "antioxidant", "and", "hepatoprotective", "activity", "of", "C.", "chinensis", "polysaccharide", "(", "CCPS", ")", "was", "demonstrated", "(", "Jiang", "et", "al.", ",", "2013", ";", "Fan", "et", "al.", ",", "2014", ")", "." ] } ]
PMC10530622	AhR expression was upregulated and negatively correlated with interferon-regulatory factor 1 (IRF1) and HIF-1α levels in a murine CaOx nephrocalcinosis model following administration of FICZ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AhR", "expression", "was", "upregulated", "and", "negatively", "correlated", "with", "interferon-regulatory", "factor", "1", "(", "IRF1", ")", "and", "HIF-1α", "levels", "in", "a", "murine", "CaOx", "nephrocalcinosis", "model", "following", "administration", "of", "FICZ", "." ] } ]
PMC11420784	n = 3 slides.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "slides", "." ] } ]
PMC9429973	Methods: We used two cell models: CD34 progenitor cells obtained from apheresis from healthy donor, driven into in vitro erythroid diffenretiation and the leukemic cell line UT7/EPO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "used", "two", "cell", "models", ":", "CD34", "progenitor", "cells", "obtained", "from", "apheresis", "from", "healthy", "donor", ",", "driven", "into", "in", "vitro", "erythroid", "diffenretiation", "and", "the", "leukemic", "cell", "line", "UT7/EPO", "." ] } ]
PMC8358006	The survival difference between two groups with or without mutations was visualized using TCGA (https://portal.gdc.cancer.gov).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "survival", "difference", "between", "two", "groups", "with", "or", "without", "mutations", "was", "visualized", "using", "TCGA", "(", "https://portal.gdc.cancer.gov", ")", "." ] } ]
PMC11704135	C NMR (CDCl3) δ(ppm) of compound 6: 188.22, 171.11, 163.41, 149.63, 139.82, 134.35, 131.58, 124.24 and 29.33.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "NMR", "(", "CDCl3", ")", "δ(ppm", ")", "of", "compound", "6", ":", "188.22", ",", "171.11", ",", "163.41", ",", "149.63", ",", "139.82", ",", "134.35", ",", "131.58", ",", "124.24", "and", "29.33", "." ] } ]
PMC5811757	Cas9 was regulated by CMV and T7 promoters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cas9", "was", "regulated", "by", "CMV", "and", "T7", "promoters", "." ] } ]
PMC9429973	To date, 2 out of 40 patients have been enrolled and are receiving therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "2", "out", "of", "40", "patients", "have", "been", "enrolled", "and", "are", "receiving", "therapy", "." ] } ]
PMC5363531	Statistical significance of the observed differences in drug-treated and untreated cells was analyzed fitting data to sigmoidal dose-response curve using GraphPad Prism software version 5.0 c. Unpaired t-tests for the differences in log IC50 for PEM alone and in combination with dasatinib were significant in all experiments with p-value < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "of", "the", "observed", "differences", "in", "drug-treated", "and", "untreated", "cells", "was", "analyzed", "fitting", "data", "to", "sigmoidal", "dose-response", "curve", "using", "GraphPad", "Prism", "software", "version", "5.0", "c.", "Unpaired", "t-tests", "for", "the", "differences", "in", "log", "IC50", "for", "PEM", "alone", "and", "in", "combination", "with", "dasatinib", "were", "significant", "in", "all", "experiments", "with", "p-value", "<", "0.001", "." ] } ]
PMC11488203	Western blot analysis of cancer cell lines representing five different tumor entities was performed for the expression of the specific SDF-1 receptors CXCR4 and CXCR7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "of", "cancer", "cell", "lines", "representing", "five", "different", "tumor", "entities", "was", "performed", "for", "the", "expression", "of", "the", "specific", "SDF-1", "receptors", "CXCR4", "and", "CXCR7", "." ] } ]
PMC11247842	On BTA6, we identified the QTL near GC, while the US study indicated one additional QTL around 50.0 Mb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "BTA6", ",", "we", "identified", "the", "QTL", "near", "GC", ",", "while", "the", "US", "study", "indicated", "one", "additional", "QTL", "around", "50.0", "Mb", "." ] } ]
PMC9429973	Summary/Conclusion: Our findings throw light on the molecular basis of HS-band 3 deficient Tunisian patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Our", "findings", "throw", "light", "on", "the", "molecular", "basis", "of", "HS-band", "3", "deficient", "Tunisian", "patients", "." ] } ]
PMC7171147	An appropriate dose of cisplatin was chosen after performing a dose response experiment in scrambled and shCPT1A cells (Fig. S6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "appropriate", "dose", "of", "cisplatin", "was", "chosen", "after", "performing", "a", "dose", "response", "experiment", "in", "scrambled", "and", "shCPT1A", "cells", "(", "Fig.", "S6C", ")", "." ] } ]
PMC9429973	The effect thereof was evaluated on hematopoietic repopulation in vivo as well as on HSPC expansion during long-term in vitro culture, using a HSPC maintaining medium (Wilkinson et al, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "thereof", "was", "evaluated", "on", "hematopoietic", "repopulation", "in", "vivo", "as", "well", "as", "on", "HSPC", "expansion", "during", "long-term", "in", "vitro", "culture", ",", "using", "a", "HSPC", "maintaining", "medium", "(", "Wilkinson", "et", "al", ",", "2020", ")", "." ] } ]
PMC6379402	Orbits are used to generalize the notion of node degree: the graphlet degrees of a node are the numbers of times a node is found at each orbit position.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Orbits", "are", "used", "to", "generalize", "the", "notion", "of", "node", "degree", ":", "the", "graphlet", "degrees", "of", "a", "node", "are", "the", "numbers", "of", "times", "a", "node", "is", "found", "at", "each", "orbit", "position", "." ] } ]
PMC10547921	In the subsequent work of PBD payloads, its conjugate sites can also be considered as a factor affecting the direction of modification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "subsequent", "work", "of", "PBD", "payloads", ",", "its", "conjugate", "sites", "can", "also", "be", "considered", "as", "a", "factor", "affecting", "the", "direction", "of", "modification", "." ] } ]
PMC9325715	However, it is noteworthy to mention that bLTF is a glycoprotein, thus in the region from 950 to 1200 cm the bands which come from vibrations of ν(C–O), νst(C–O), νst(C–C) of carbohydrates can occur.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "is", "noteworthy", "to", "mention", "that", "bLTF", "is", "a", "glycoprotein", ",", "thus", "in", "the", "region", "from", "950", "to", "1200", "cm", "the", "bands", "which", "come", "from", "vibrations", "of", "ν(C", "–", "O", ")", ",", "νst(C", "–", "O", ")", ",", "νst(C", "–", "C", ")", "of", "carbohydrates", "can", "occur", "." ] } ]
PMC11682224	COX-2 has also been associated with enhanced invasiveness and increased metastatic potential of tumour cells, which can be achieved through the promotion of MMP expression, increased angiogenesis, and alteration of the extracellular matrix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COX-2", "has", "also", "been", "associated", "with", "enhanced", "invasiveness", "and", "increased", "metastatic", "potential", "of", "tumour", "cells", ",", "which", "can", "be", "achieved", "through", "the", "promotion", "of", "MMP", "expression", ",", "increased", "angiogenesis", ",", "and", "alteration", "of", "the", "extracellular", "matrix", "." ] } ]
PMC11055443	The Mean percentage of necrosis in treatment with V. cholerae. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Mean", "percentage", "of", "necrosis", "in", "treatment", "with", "V.", "cholerae", ".", "(" ] } ]
PMC11769516	Furthermore, it has been shown that the exposure of animals to mycotoxins can cause behavioral disorders, in particular, cognitive deficits and anxiety-like behaviors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "it", "has", "been", "shown", "that", "the", "exposure", "of", "animals", "to", "mycotoxins", "can", "cause", "behavioral", "disorders", ",", "in", "particular", ",", "cognitive", "deficits", "and", "anxiety-like", "behaviors", "." ] } ]
PMC11787651	The top 30 most differentially expressed peptides were plotted in a heatmap for each method (Fig. 4, C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "30", "most", "differentially", "expressed", "peptides", "were", "plotted", "in", "a", "heatmap", "for", "each", "method", "(", "Fig.", "4", ",", "C", "and", "D", ")", "." ] } ]
PMC11703992	Via single-cell analysis and MR analysis, we comprehensively explored the changes in CD4+ Memory T cells in GCA and investigated the roles of two significant genes, DDIT4 and ARHGAP15, in the progression of the disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Via", "single-cell", "analysis", "and", "MR", "analysis", ",", "we", "comprehensively", "explored", "the", "changes", "in", "CD4", "+", "Memory", "T", "cells", "in", "GCA", "and", "investigated", "the", "roles", "of", "two", "significant", "genes", ",", "DDIT4", "and", "ARHGAP15", ",", "in", "the", "progression", "of", "the", "disease", "." ] } ]
PMC11388384	SHH sender and receiver cells were plated as for measuring SHH signaling gradients, and induced to signal for 48 h. Cells were fixed for 30 min in 4% formaldehyde in PBS, and were permeabilized for 10 min at −20 °C with a solution of equal parts methanol and acetone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SHH", "sender", "and", "receiver", "cells", "were", "plated", "as", "for", "measuring", "SHH", "signaling", "gradients", ",", "and", "induced", "to", "signal", "for", "48", "h.", "Cells", "were", "fixed", "for", "30", "min", "in", "4", "%", "formaldehyde", "in", "PBS", ",", "and", "were", "permeabilized", "for", "10", "min", "at", "−20", "°", "C", "with", "a", "solution", "of", "equal", "parts", "methanol", "and", "acetone", "." ] } ]
PMC11785489	The union of variable genes across samples totaled 6358 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "union", "of", "variable", "genes", "across", "samples", "totaled", "6358", "genes", "." ] } ]
PMC10170482	Finally, the master reaction mix, consisting of the pyruvate assay buffer, pyruvate probe solution (5× diluted), and pyruvate enzyme mix, was added to samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "master", "reaction", "mix", ",", "consisting", "of", "the", "pyruvate", "assay", "buffer", ",", "pyruvate", "probe", "solution", "(", "5", "×", "diluted", ")", ",", "and", "pyruvate", "enzyme", "mix", ",", "was", "added", "to", "samples", "." ] } ]
PMC9429973	Secondary end points included safety, objective response rate (ORR), and duration of response (DOR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "end", "points", "included", "safety", ",", "objective", "response", "rate", "(", "ORR", ")", ",", "and", "duration", "of", "response", "(", "DOR", ")", "." ] } ]
PMC11732523	Fig. 1Evolution of chest CT images following COVID-19 infection. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1Evolution", "of", "chest", "CT", "images", "following", "COVID-19", "infection", ".", "(" ] } ]
PMC11637276	MDA-MB-231 cells were transfected as in (a), seeded on 1 mg/ml collagen I, labelled with NHS-Alexa Fluor 555, for 6 h, fixed and stained for α2 integrin (ITGA2) and nuclei.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDA-MB-231", "cells", "were", "transfected", "as", "in", "(", "a", ")", ",", "seeded", "on", "1", "mg/ml", "collagen", "I", ",", "labelled", "with", "NHS-Alexa", "Fluor", "555", ",", "for", "6", "h", ",", "fixed", "and", "stained", "for", "α2", "integrin", "(", "ITGA2", ")", "and", "nuclei", "." ] } ]
PMC11509309	Psammaplysene A has recently been shown to reduce prion levels in prion-infected cells and cerebellar organotypic slices and to alleviate locomotor deficits in prion-infected Drosophila expressing ovine PrP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Psammaplysene", "A", "has", "recently", "been", "shown", "to", "reduce", "prion", "levels", "in", "prion-infected", "cells", "and", "cerebellar", "organotypic", "slices", "and", "to", "alleviate", "locomotor", "deficits", "in", "prion-infected", "Drosophila", "expressing", "ovine", "PrP", "." ] } ]
PMC10582049	ADH1B CAFs could potentially be used as a marker to predict LUAD behavior and for a better understanding of the biological mechanisms associated with LUAD aggressiveness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ADH1B", "CAFs", "could", "potentially", "be", "used", "as", "a", "marker", "to", "predict", "LUAD", "behavior", "and", "for", "a", "better", "understanding", "of", "the", "biological", "mechanisms", "associated", "with", "LUAD", "aggressiveness", "." ] } ]
PMC9429973	Mutations and genomic risk features evident at baseline were compared across PD and non-PD pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "and", "genomic", "risk", "features", "evident", "at", "baseline", "were", "compared", "across", "PD", "and", "non-PD", "pts", "." ] } ]
PMC8409415	Approximately 10%‐30% of women with advanced OvCA received NACT in the early 2000s, and the rate of NACT use has nearly doubled in the following decade.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "10%‐30", "%", "of", "women", "with", "advanced", "OvCA", "received", "NACT", "in", "the", "early", "2000s", ",", "and", "the", "rate", "of", "NACT", "use", "has", "nearly", "doubled", "in", "the", "following", "decade", ".", "," ] } ]
PMC10094992	Light microscope images of untreated and NR6-treated (24 and 72 h) MSTO-211H MCSs are shown in Figure 2A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Light", "microscope", "images", "of", "untreated", "and", "NR6-treated", "(", "24", "and", "72", "h", ")", "MSTO-211H", "MCSs", "are", "shown", "in", "Figure", "2A", "." ] } ]
PMC11705630	We examined the expression levels of GLDC in the non-tumor and tumor kidney tissues from RCC patients with poor prognosis and found that expressions of GLDC were dramatically higher in the tumor tissues than those in non-tumor tissues, a finding that provides a novel therapeutic target for the treatment of RCC (Fig. 8F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "examined", "the", "expression", "levels", "of", "GLDC", "in", "the", "non-tumor", "and", "tumor", "kidney", "tissues", "from", "RCC", "patients", "with", "poor", "prognosis", "and", "found", "that", "expressions", "of", "GLDC", "were", "dramatically", "higher", "in", "the", "tumor", "tissues", "than", "those", "in", "non-tumor", "tissues", ",", "a", "finding", "that", "provides", "a", "novel", "therapeutic", "target", "for", "the", "treatment", "of", "RCC", "(", "Fig.", "8F", ")", "." ] } ]
PMC11342785	Scale bar represents 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "represents", "20", "μm", "." ] } ]
PMC10297204	Ninth, we did not conduct experiments using ethanol concentrations of 30–99.5%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ninth", ",", "we", "did", "not", "conduct", "experiments", "using", "ethanol", "concentrations", "of", "30–99.5", "%", "." ] } ]
PMC11802929	An APMAT analysis centered around those most common alleles should offer valuable insights for assessing the therapeutic potential of tumor-targeting TCRs and T cell vaccines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "APMAT", "analysis", "centered", "around", "those", "most", "common", "alleles", "should", "offer", "valuable", "insights", "for", "assessing", "the", "therapeutic", "potential", "of", "tumor-targeting", "TCRs", "and", "T", "cell", "vaccines", "." ] } ]
PMC11656380	Western blot analysis showed that cell lines susceptible to Tat-Ram13-induced cell death exhibited little or no PTEN expression (Figure 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "showed", "that", "cell", "lines", "susceptible", "to", "Tat-Ram13-induced", "cell", "death", "exhibited", "little", "or", "no", "PTEN", "expression", "(", "Figure", "4E", ")", "." ] } ]
PMC11683240	α1AT, α1-antitrypsin; FCS, fetal calf serum; Gαi, α-subunit of inhibitory G protein; PT, pertussis toxin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "FCS", ",", "fetal", "calf", "serum", ";", "Gαi", ",", "α-subunit", "of", "inhibitory", "G", "protein", ";", "PT", ",", "pertussis", "toxin", "." ] } ]
PMC6461034	GDSC data indicate that SK‐Mel‐28 is sensitive to inhibition of BRAF and downstream MAP2K1/2 (MEK1/2) and, to a lesser extent, MAPK3/1 (ERK1/2).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GDSC", "data", "indicate", "that", "SK‐Mel‐28", "is", "sensitive", "to", "inhibition", "of", "BRAF", "and", "downstream", "MAP2K1/2", "(", "MEK1/2", ")", "and", ",", "to", "a", "lesser", "extent", ",", "MAPK3/1", "(", "ERK1/2", ")", "." ] } ]
PMC9429973	Appropriate humoral and cellular responses are seen in patients with SAA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Appropriate", "humoral", "and", "cellular", "responses", "are", "seen", "in", "patients", "with", "SAA", "." ] } ]
PMC11754784	f Flow cytometry analysis and confocal imaging of CEM cells bound by cage-Nb and Nb-S to characterize the protection of DNA cage on Nb binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "Flow", "cytometry", "analysis", "and", "confocal", "imaging", "of", "CEM", "cells", "bound", "by", "cage-Nb", "and", "Nb-S", "to", "characterize", "the", "protection", "of", "DNA", "cage", "on", "Nb", "binding", "." ] } ]
PMC11781181	Our results confirmed that miR-375-3p-mediated keratinocyte ferroptosis was partially mitigated in FSP1-overexpressing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "confirmed", "that", "miR-375", "-", "3p-mediated", "keratinocyte", "ferroptosis", "was", "partially", "mitigated", "in", "FSP1-overexpressing", "cells", "." ] } ]
PMC11279598	Human breast cancer cell lines were obtained from the American Type Culture Collection (ATCC) (Manassas, VA, USA) and cultured according to ATCC recommendations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "breast", "cancer", "cell", "lines", "were", "obtained", "from", "the", "American", "Type", "Culture", "Collection", "(", "ATCC", ")", "(", "Manassas", ",", "VA", ",", "USA", ")", "and", "cultured", "according", "to", "ATCC", "recommendations", "." ] } ]
PMC10142392	To meet this requirement, various biocompatible polymers such as PEO, PLA, and PCL have been tested .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "meet", "this", "requirement", ",", "various", "biocompatible", "polymers", "such", "as", "PEO", ",", "PLA", ",", "and", "PCL", "have", "been", "tested", "." ] } ]
PMC11392912	The bar graph represents the optical density of TNF-α plasma level in rats, shown downregulated in Clo-miR-14 treated group plasma samples compared with the CIA and NC group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bar", "graph", "represents", "the", "optical", "density", "of", "TNF-α", "plasma", "level", "in", "rats", ",", "shown", "downregulated", "in", "Clo-miR-14", "treated", "group", "plasma", "samples", "compared", "with", "the", "CIA", "and", "NC", "group", ".", "(" ] } ]
PMC11703992	Furthermore, to identify the potential transcriptomic factor (TF) regulatory networks in CD4+ Memory T cell subtypes, we performed SCENIC (ver 1.3.1) analysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "to", "identify", "the", "potential", "transcriptomic", "factor", "(", "TF", ")", "regulatory", "networks", "in", "CD4", "+", "Memory", "T", "cell", "subtypes", ",", "we", "performed", "SCENIC", "(", "ver", "1.3.1", ")", "analysis", "." ] } ]
PMC11679033	Some authors, however, reported positive results of MN assay on human liver cell line (HepG2) and in buccal-derived cells (TR146), pointing to damage at levels above 0.2 µM and associated them with oxidative base damage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "authors", ",", "however", ",", "reported", "positive", "results", "of", "MN", "assay", "on", "human", "liver", "cell", "line", "(", "HepG2", ")", "and", "in", "buccal-derived", "cells", "(", "TR146", ")", ",", "pointing", "to", "damage", "at", "levels", "above", "0.2", "µM", "and", "associated", "them", "with", "oxidative", "base", "damage", "." ] } ]
PMC10874773	Fang et al. used MTT method to study the cytotoxicity of majusatone (92).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fang", "et", "al.", "used", "MTT", "method", "to", "study", "the", "cytotoxicity", "of", "majusatone", "(", "92", ")", "." ] } ]

PMC11739484

Understanding the molecular mechanisms underlying its progression and identifying reliable biomarkers is crucial for developing effective diagnostic and therapeutic strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "molecular", "mechanisms", "underlying", "its", "progression", "and", "identifying", "reliable", "biomarkers", "is", "crucial", "for", "developing", "effective", "diagnostic", "and", "therapeutic", "strategies", "." ] } ]

PMC6650823

Highlighted by Rino Ragno Venetoclax (Ven ABT-199) is the first BCL-2 antagonist approved for Chronic Lymphocytic Leukemia (CLL), and Acute Myeloid Leukemia (AML) therapy in 2016.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Highlighted", "by", "Rino", "Ragno", "Venetoclax", "(", "Ven", "ABT-199", ")", "is", "the", "first", "BCL-2", "antagonist", "approved", "for", "Chronic", "Lymphocytic", "Leukemia", "(", "CLL", ")", ",", "and", "Acute", "Myeloid", "Leukemia", "(", "AML", ")", "therapy", "in", "2016", "." ] } ]

PMC11066331

Here we investigated five machine learning algorithms (k-nearest neighbors, decision tree, random forest, partial least squares discrimination, and artificial neural network) and optimized their performance either in pure populations or in two-component mixtures composed of cells with normal or silenced expression of TUSC3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "investigated", "five", "machine", "learning", "algorithms", "(", "k-nearest", "neighbors", ",", "decision", "tree", ",", "random", "forest", ",", "partial", "least", "squares", "discrimination", ",", "and", "artificial", "neural", "network", ")", "and", "optimized", "their", "performance", "either", "in", "pure", "populations", "or", "in", "two-component", "mixtures", "composed", "of", "cells", "with", "normal", "or", "silenced", "expression", "of", "TUSC3", "." ] } ]

PMC11301931

Ferroptosis is an iron-dependent form of cell death characterized by the peroxidation of membrane polyunsaturated fatty acids, leading to membrane damage and cell death.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "is", "an", "iron-dependent", "form", "of", "cell", "death", "characterized", "by", "the", "peroxidation", "of", "membrane", "polyunsaturated", "fatty", "acids", ",", "leading", "to", "membrane", "damage", "and", "cell", "death", "." ] } ]

PMC11756907

Figure 4Cytotoxicity of the tested samples against 143B cells line expressed as % of cell viability ((A) results for GO; (B) results for GO-2ME vs 2ME; (C) results for RGO; (D) results for RGO-2ME vs 2ME).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4Cytotoxicity", "of", "the", "tested", "samples", "against", "143B", "cells", "line", "expressed", "as", "%", "of", "cell", "viability", "(", "(", "A", ")", "results", "for", "GO", ";", "(", "B", ")", "results", "for", "GO-2ME", "vs", "2ME", ";", "(", "C", ")", "results", "for", "RGO", ";", "(", "D", ")", "results", "for", "RGO-2ME", "vs", "2ME", ")", "." ] } ]

PMC11612794

S175 and T184 of CENP-T are labeled.

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PMC8728081

Thermal analysis was carried out with thermogravimetric analysis (TGA) attached with differential thermal analysis (DTA).

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PMC9429973

R-CHOP and BR were the second most used regimen in 1L with decreased use in 2L+.

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PMC8992508

These natural compounds are important constituents of human diet and are well known for their beneficial effects on health.

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PMC10976516

NCT04495153ColoAd1, chimeric adenovirus strain (enadenotucirev)Ii.v.

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PMC10604092

Our novel cancer cachexia rat model is a promising tool to elucidate the pathogenesis of cancer cachexia and to conduct further research on the development of treatments and supportive care for patients with this disease.

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PMC11746948

Observation for lung metastatic tumor development three weeks later.

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PMC11656657

p-value ≤ 0.05; **p-value ≤ 0.01; ***p-value ≤ 0.001 and **** ≤ 0.0001 In vivo experiments of NSG mice bearing GD2 + sarcoma cells (RD, 143B or U-2OS) treated with NT or CAR.GD2 T-cells.

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PMC10197932

However, a complete understanding of the effects of ultrasound on cells has not been achieved yet.

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PMC11481779

It can be easily distinguished from real data.

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PMC11075223

The identification methods of Cimicifugae Rhizoma including thin layer chromatography, microscopic identification, moisture, ash and impurity detection were described in ChP .

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PMC11733919

Furthermore, cancer cells can adapt to oxidative stress by increasing the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) promoting tumorigenesis by the expression of numerous antioxidant proteins such as the regulators of GSH synthesis and metabolism, for example, GPX4.

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PMC11448304

Chen et al. identified 2011 Khib modified sites on 764 proteins in oral adenoid cystic carcinoma and deduced that Khib modifications promote cancer progression.

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PMC9985266

In lung epithelial and lung fibroblast cells, reduced autophagic pathways were found in patients with idiopathic pulmonary fibrosis (IPF) .

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PMC9429973

All included patients had a previous AIHA history or developed/exacerbated AIHA during gestation or postpartum.

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PMC8592717

These have been widely used in the treatment of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years.

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PMC7090062

After treatment with RAPA, the miR-30 inhibitor also had no obvious influence on GIST cell viability in the context of IM intervention (Fig. 5b).

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PMC8481254

CA can inhibit the activation of the HBP pathway and reduce the expression of YAP and OGT under HG conditions.

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PMC11591794

The SRplot bioinformatics program was used to evaluate these data.

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PMC11604830

These findings present a promising avenue for nanoparticle imaging in biomedical applications, offering potential enhancements to diagnostic and theranostic procedures.

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PMC11687167

The mechanisms underlying these findings were related to the fact that the L-IFPTA + vaccine triggered functional anti-PCSK9 antibodies targeting circulating PCSK9, thereby reducing the plasma levels and activity of PCSK9 in mice.

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PMC11244823

It had been obtained from a four-month-old foal from Iceland, whose data about health or vaccination were not available.

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PMC11731614

We used the following antibodies on skin sections: K14 (BioLegend 906004).

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PMC11792888

Bar graph from Bax. (

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PMC9429973

In the analysis of Langenhorst et al. the optimal AUC was postulated to be 20 mg*h/l.

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PMC6468656

ACHN, A-498 and A-704 cells were maintained in MEM medium supplemented with 10% fetal bovine serum, penicillin (100 unit/mL), and streptomycin (100 μg/mL).

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PMC11799620

Table 1 presents the total phenolic amount of this extract.

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PMC11001582

We also built DPR constructs in the patient range, comprising 400 uninterrupted polyGR or polyPR repeats, to replicate patient DPRs as closely as possible.

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PMC9429973

TP53 pathogenic variants were present in 26% of cases and were associated with a significantly inferior event free and overall survival compared to those without a TP53 abnormality: 45,3% (95%CI = 21-69,6%) vs 97,9% (95%CI=93,9-100%) (p < 0.001) and 47,1% (95%CI=21,8-72,4%) vs 97,9% (95%CI= 93,9-100%) respectively (p = 0.001).

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PMC8143558

Soaps enhance the removal of microorganisms and dirt from body and other surfaces because they denature the microorganisms and emulsify the dirt thus performing a dual role of disinfection and cleaning.

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PMC6461034

AXL, inactive in parental cells (see Appendix Fig S8), but associated with erlotinib resistance in this subline, can only be analyzed through the kinase‐centric arm (pink bar highlighting).

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PMC10932641

Long noncoding RNA (lncRNA) GPRC5D-AS1 can serve as a biomarker in clinical applications and the prognosis of lung squamous cell carcinoma.

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PMC11453853

We propose that abnormal growth factor signaling in breast cancer cells permits PR/ER complex formation which promotes expression of genes that induce endocrine resistance and CSC expansion through regulation of super enhancer elements.

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PMC11769516

This effect was not observed after exposure to α-ZEL.

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PMC11591038

The major pathological characteristics of Alzheimer’s disease (AD) include senile plaques and neurofibrillary tangles (NFTs), which are mainly composed of aggregated amyloid-beta (Aβ) peptide and hyperphosphorylated tau protein, respectively.

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PMC6600253

In general, there are three typical strategies for TIS that can be considered: (i) the activation of DDR-related senescence by radiation or genotoxic chemotherapeutics, (ii) the reactivation of senescence-mediated tumor suppressor genes, and (iii) the induction of cytokine-induced senescence (CIS).

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PMC11537649

The transfection efficiency was confirmed by qRT-PCR.

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PMC11126803

We generated luciferase stably transfected A498 cells.

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PMC9429973

All patients have indication for systemic therapy.

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PMC7759933

The qPCR experiments were performed on 48.48 Dynamic Array™ IFC chips for gene expression on the BioMark HD machine system (Fluidigm, UK) and data were analysed with an open web program QuantGenious .

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PMC11748335

A previous study has reported that broad H3K27me3 regions are enriched for oncogenes (OGs), but the influence of different DNA methylation backgrounds was not considered .

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PMC11269792

GeTu ZhaoRi and ChunJuan Wang designed the research study.

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PMC9429973

Among 188 BAT LOTs with agent-level data available, most common treatments were midostaurin (53%) and cladribine (24%).

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PMC10728200

Significance denoted by: ns not significant, *P < 0.05, **P < 0.01, and ***P < 0.001.

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PMC4277423

The downloaded sequence was used to build a bowtie reference database.

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PMC9884169

Ferroptosis is a form of programmed cell death different from apoptosis and necrosis [7–9].

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PMC9243326

In an alcohol-induced liver injury model, the significant antioxidant and hepatoprotective activity of C. chinensis polysaccharide (CCPS) was demonstrated (Jiang et al., 2013; Fan et al., 2014).

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PMC10530622

AhR expression was upregulated and negatively correlated with interferon-regulatory factor 1 (IRF1) and HIF-1α levels in a murine CaOx nephrocalcinosis model following administration of FICZ.

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PMC11420784

n = 3 slides.

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PMC9429973

Methods: We used two cell models: CD34 progenitor cells obtained from apheresis from healthy donor, driven into in vitro erythroid diffenretiation and the leukemic cell line UT7/EPO.

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PMC8358006

The survival difference between two groups with or without mutations was visualized using TCGA (https://portal.gdc.cancer.gov).

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PMC11704135

C NMR (CDCl3) δ(ppm) of compound 6: 188.22, 171.11, 163.41, 149.63, 139.82, 134.35, 131.58, 124.24 and 29.33.

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PMC5811757

Cas9 was regulated by CMV and T7 promoters.

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PMC9429973

To date, 2 out of 40 patients have been enrolled and are receiving therapy.

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PMC5363531

Statistical significance of the observed differences in drug-treated and untreated cells was analyzed fitting data to sigmoidal dose-response curve using GraphPad Prism software version 5.0 c. Unpaired t-tests for the differences in log IC50 for PEM alone and in combination with dasatinib were significant in all experiments with p-value < 0.001.

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PMC11488203

Western blot analysis of cancer cell lines representing five different tumor entities was performed for the expression of the specific SDF-1 receptors CXCR4 and CXCR7.

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PMC11247842

On BTA6, we identified the QTL near GC, while the US study indicated one additional QTL around 50.0 Mb.

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PMC9429973

Summary/Conclusion: Our findings throw light on the molecular basis of HS-band 3 deficient Tunisian patients.

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PMC7171147

An appropriate dose of cisplatin was chosen after performing a dose response experiment in scrambled and shCPT1A cells (Fig. S6C).

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PMC9429973

The effect thereof was evaluated on hematopoietic repopulation in vivo as well as on HSPC expansion during long-term in vitro culture, using a HSPC maintaining medium (Wilkinson et al, 2020).

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PMC6379402

Orbits are used to generalize the notion of node degree: the graphlet degrees of a node are the numbers of times a node is found at each orbit position.

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PMC10547921

In the subsequent work of PBD payloads, its conjugate sites can also be considered as a factor affecting the direction of modification.

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PMC9325715

However, it is noteworthy to mention that bLTF is a glycoprotein, thus in the region from 950 to 1200 cm the bands which come from vibrations of ν(C–O), νst(C–O), νst(C–C) of carbohydrates can occur.

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PMC11682224

COX-2 has also been associated with enhanced invasiveness and increased metastatic potential of tumour cells, which can be achieved through the promotion of MMP expression, increased angiogenesis, and alteration of the extracellular matrix.

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PMC11055443

The Mean percentage of necrosis in treatment with V. cholerae. (

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PMC11769516

Furthermore, it has been shown that the exposure of animals to mycotoxins can cause behavioral disorders, in particular, cognitive deficits and anxiety-like behaviors .

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PMC11787651

The top 30 most differentially expressed peptides were plotted in a heatmap for each method (Fig. 4, C and D).

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PMC11703992

Via single-cell analysis and MR analysis, we comprehensively explored the changes in CD4+ Memory T cells in GCA and investigated the roles of two significant genes, DDIT4 and ARHGAP15, in the progression of the disease.

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PMC11388384

SHH sender and receiver cells were plated as for measuring SHH signaling gradients, and induced to signal for 48 h. Cells were fixed for 30 min in 4% formaldehyde in PBS, and were permeabilized for 10 min at −20 °C with a solution of equal parts methanol and acetone.

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PMC11785489

The union of variable genes across samples totaled 6358 genes.

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PMC10170482

Finally, the master reaction mix, consisting of the pyruvate assay buffer, pyruvate probe solution (5× diluted), and pyruvate enzyme mix, was added to samples.

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PMC9429973

Secondary end points included safety, objective response rate (ORR), and duration of response (DOR).

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PMC11732523

Fig. 1Evolution of chest CT images following COVID-19 infection. (

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PMC11637276

MDA-MB-231 cells were transfected as in (a), seeded on 1 mg/ml collagen I, labelled with NHS-Alexa Fluor 555, for 6 h, fixed and stained for α2 integrin (ITGA2) and nuclei.

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PMC11509309

Psammaplysene A has recently been shown to reduce prion levels in prion-infected cells and cerebellar organotypic slices and to alleviate locomotor deficits in prion-infected Drosophila expressing ovine PrP .

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PMC10582049

ADH1B CAFs could potentially be used as a marker to predict LUAD behavior and for a better understanding of the biological mechanisms associated with LUAD aggressiveness.

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PMC9429973

Mutations and genomic risk features evident at baseline were compared across PD and non-PD pts.

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PMC8409415

Approximately 10%‐30% of women with advanced OvCA received NACT in the early 2000s, and the rate of NACT use has nearly doubled in the following decade.,

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PMC10094992

Light microscope images of untreated and NR6-treated (24 and 72 h) MSTO-211H MCSs are shown in Figure 2A.

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PMC11705630

We examined the expression levels of GLDC in the non-tumor and tumor kidney tissues from RCC patients with poor prognosis and found that expressions of GLDC were dramatically higher in the tumor tissues than those in non-tumor tissues, a finding that provides a novel therapeutic target for the treatment of RCC (Fig. 8F).

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PMC11342785

Scale bar represents 20 μm.

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PMC10297204

Ninth, we did not conduct experiments using ethanol concentrations of 30–99.5%.

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PMC11802929

An APMAT analysis centered around those most common alleles should offer valuable insights for assessing the therapeutic potential of tumor-targeting TCRs and T cell vaccines.

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PMC11656380

Western blot analysis showed that cell lines susceptible to Tat-Ram13-induced cell death exhibited little or no PTEN expression (Figure 4E).

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PMC11683240

α1AT, α1-antitrypsin; FCS, fetal calf serum; Gαi, α-subunit of inhibitory G protein; PT, pertussis toxin.

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PMC6461034

GDSC data indicate that SK‐Mel‐28 is sensitive to inhibition of BRAF and downstream MAP2K1/2 (MEK1/2) and, to a lesser extent, MAPK3/1 (ERK1/2).

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PMC9429973

Appropriate humoral and cellular responses are seen in patients with SAA.

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PMC11754784

f Flow cytometry analysis and confocal imaging of CEM cells bound by cage-Nb and Nb-S to characterize the protection of DNA cage on Nb binding.

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PMC11781181

Our results confirmed that miR-375-3p-mediated keratinocyte ferroptosis was partially mitigated in FSP1-overexpressing cells.

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PMC11279598

Human breast cancer cell lines were obtained from the American Type Culture Collection (ATCC) (Manassas, VA, USA) and cultured according to ATCC recommendations.

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PMC10142392

To meet this requirement, various biocompatible polymers such as PEO, PLA, and PCL have been tested .

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PMC11392912

The bar graph represents the optical density of TNF-α plasma level in rats, shown downregulated in Clo-miR-14 treated group plasma samples compared with the CIA and NC group. (

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PMC11703992

Furthermore, to identify the potential transcriptomic factor (TF) regulatory networks in CD4+ Memory T cell subtypes, we performed SCENIC (ver 1.3.1) analysis .

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PMC11679033

Some authors, however, reported positive results of MN assay on human liver cell line (HepG2) and in buccal-derived cells (TR146), pointing to damage at levels above 0.2 µM and associated them with oxidative base damage .

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PMC10874773

Fang et al. used MTT method to study the cytotoxicity of majusatone (92).

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