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PMC9428827
on the right flank; 4T1 cells were inoculated on mammary glands. (
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PMC10047551
PD-1/PD-L1 immunotherapy resistance in NSCLC is described, e.g., as being attributed to the loss-of-function of IFN signaling and the resulting decrease in IFN-γ-induced PD-L1 expression in cancer cells .
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PMC9429973
PK deficiency is associated with serious complications, regardless of transfusion status.
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PMC10887351
In A/J mice, the syngeneic Neuro2A NB cells were inoculated with the β3-AR antagonist, a PD-L1 monoclonal antibody (αPD-L1), or their combination.
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PMC11473750
Next, we performed ChIP with an anti-IgG or anti-MYCN antibody, followed by real-time PCR with primers targeting either a negative control region (Control, −2285 bp) or the putative MYCN binding site (−136 bp) upstream of the RNF121 transcription start site (Fig. 5f).
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PMC11422497
shRNA: short hairpin RNA.
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PMC9454178
Apoptosis-related proteins were also detected.
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PMC11401350
This means that in terms of safety, these CD8-targeted LVs might also be of benefit in the case of ex vivo CAR T therapy since contamination of the CD8-purified cell subset with CD4 + T cells cannot be entirely excluded when using polytropic VSV-G-LVs.
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PMC10538569
mDC phenotype was confirmed by flow cytometry using antibodies against CD83, CD86, CD209 and HLA-DR (see below).
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PMC11360263
Notably, colony formation was observed in soft agar cultures containing CTH, CTO, and CTP-DB and BL, in contrast to uninfected HMECs, OECs, and PECs.
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PMC11621565
An article published in 2018 studied the fibrillation kinetics between rhamnolipid and α-synuclein and showed that rhamnolipid micelles induced the formation of α-synuclein fibrillates.
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PMC11093197
Representative image of colony formation assay for Scr, shRB1#1, or shRB1#2 in MCF10A. (
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PMC11711127
Indeed, physiologically, whether tolDCs even represent a stable lineage, as opposed to a transient maturation state, is far from certain (106).
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PMC11463018
Ethoxycarbonyl isothiocyanate reacted with 11 to form the thiourea 12, which was then reacted with hydroxylamine to yield the desired intermediate 13 with N, N-diisopropylethylamine (DIPEA) as the base.
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PMC11675244
In the skeletal system, Wnt signaling affects the proliferation and differentiation of mesenchymal stem cells and osteoclasts, contributing to bone formation and maintenance of mass and strength .
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PMC11240571
However, cancer has been implicated in preventing attacks from the immune system by suppressing T cell activation by binding the PD-L1 expressed on cancer cells to the PD-1 on cytotoxic T cells .
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PMC11547972
Experiments were conducted with both asynchronous and synchronous tumor cells.
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PMC7868205
The purpose of these trials is to identify the toxicity profile and therapeutic effects with an intention of screening a drug.61–63 Therefore, we analysed the cytotoxicity of AgNPs on normal HEK-293 and HeLa cells, in order to indicate its therapeutic window.
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PMC6461034
Put a 15‐ml tube with lysate on ice just before sonication (urea will precipitate out after prolonged cooling).
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PMC9429973
On the contrary, among the 13 patients who did not develop nAbs after the first dose, only 5 (38.4%) were found with increased levels of soluble C5b-9 (p=0.042).
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PMC11718274
The intensity of emitted fluorescent light was measured using ImageJ/FIJI free software.
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PMC11700165
Western blot analysis of SYF cells transfected with IS, BS or TS along with SLP-76 in the presence or absence of SRC.
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PMC11621565
However, starting from 160 µg/ml, a steep loss of cell viability was noticed, with 3.82% ± 1 viability at 160 µg/ml (p < 0.001) and 2% ± 1.5 viability at 320 µg/ml (p < 0.001).
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PMC9429973
Patients with LPD are older, they have significantly higher inflammatory parameters and more frequent presence of comorbidities compared to patients from GP.
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PMC11656657
The IFNγ spot-forming cells (SFC) were enumerated (ZellNet).
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PMC9895440
Animals were housed under specific pathogen-free conditions.
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PMC11240448
Summarizing, the conclusions derived from the consensus network hold true for luminal BC cell lines.
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PMC10758402
Once the tumors reached a volume of approximately 100mm after 11 days, mice were injected either intratumorally or given DMF by oral gavage (200mg/kg).
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PMC9429973
Methods: The study included 45 patients with HL in patients with HIV who received treatment in 9 Russian centers from 2007 to 2021.
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PMC11711663
Normalization was achieved by scaling the HU values to a uniform range across patients, specifically by subtracting the mean and dividing the voxel values by the standard deviation.
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PMC9429973
The LymphGen tool classified 29 out of 54 pts (54%) in defined clusters, including 14 in BN2 (48%), 7 in ST2 (24%), 4 in MCD (14%) and 4 in EZB subtype (14%).
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PMC7039683
Raw and processed sequencing data for RNA-seq were deposited in GEO repository (GSE140241).
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PMC11185260
Tumor volumes are shown for individual tumor (left panel) and on average (right panel).
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PMC9429973
Results: Patients with a baseline score and at least one postbaseline score were included in the analysis.
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PMC9429973
Image: Summary/Conclusion: Pts receiving luspatercept had an extended period of clinical benefit and >50% of pts continued to receive luspatercept for >1 y, the majority of whom underwent dose escalations to achieve an optimal response.
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PMC11218145
Ren cells were transduced with aequorin targeted to the mitochondrial (upper panel) and cytosolic (lower panel) compartments and treated with TB at different time points.
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PMC11707577
To test the cytotoxic oxidative stress induced by M13EGFR(TNP) in A431 cells, upon illumination, we used ROS‐Glo™ as a reporter to monitor the intracellular formation of reactive oxygen species (ROS).
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PMC9429973
Thirty-five percent of patients experiencing AHP for 0–5 years reported a GAD-7 score ≥10, compared with 51% of patients experiencing AHP for ≥6 years.
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PMC11036064
.
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PMC4659567
The studied complex 2 showed six pairs of C13,15–H2/C12,16–H2 signals at 6.16/5.87, 6.04/5.79, 5.97/5.83, 5.91/5.68, 5.65/5.23 and 5.58/5.44 ppm, and three sets of signals in the region of 7-azaindole aromatic hydrogens of 3Claza represented by C2–H singlets at 7.67, 7.62 and 7.60 ppm (S4 Fig), but the position of none of these C2–H signals did not correlate with the signals of free (i.e. released) 3Claza in 10% MeOD-d 4/D2O.
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PMC9429973
The non-responder patients were switched to another line and excluded.
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PMC11699465
Data are represented as mean ± SEM.(F–H) Western blotting to show the TMEM199 protein level and PD-L1 protein level under TMEM199 knockdown conditions.
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PMC9917080
In our experiments, the treatment of A-172 glioblastoma cells for 24 and 48 h with sorafenib led to an increase in the expression of mRNA of the spliced form of the XBP1s transcription factor and did not change the expression of two other markers of ER-stress, ATF-4 and ATF-6 (Figure 7A,B).
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PMC6600592
Pale yellow liquid, yield 79.3%.
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PMC11406030
Intensity was rated on a scale ranging from 0–3, with 0 indicating negative staining, 1 indicating weak staining, 2 indicating moderate staining, and 3 reflecting strong staining.
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PMC11291697
She was born at full term by caesarean section.
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PMC11377827
The screens were performed in HeLa cells expressing a well-validated HIF reporter (HIFGFP reporter), which we have previously used to interrogate the regulation of the HIF response (Bailey et al, 2020; Burr et al, 2016; Ortmann et al, 2021).
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PMC11144382
Extraction of DNA and RNA, DNA and RNA sequence analyses; generation of NFIX expression constructs, immunofluorescence, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and western blot analyses; and dual luciferase reporter activity assays, chromatin immunoprecipitation (ChIP) followed by real time-PCR (ChIP-RT-PCR), RNA sequencing, proteomics, and in silico analyses, were performed as described in Supplemental Materials and Methods.
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PMC11700165
SYK fusion kinases were equally phosphorylated at Tyrosine 352 and 525/526 in the linker-region and activation-loop that play a key role in the activation of SYK, and they potently trans-phosphorylated the SLP-76 substrate in COS-7 cells (Fig. 1B, Supplementary Figure S1A).
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PMC11257988
The data also indicated that the patients who received ICI plus chemotherapy had significantly longer survival than those who received monotherapy .Table 1KRAS status as a predictive biomarker for lung cancer.
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PMC11577421
Points represent the average of three measurements.
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PMC9429973
Aims: This study aims to generate and characterize AML patient derived xenografts (PDXs) and accelerate the evaluation of innovative medicines for AML.
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PMC9646302
We found that the number of cell clones and the cell proliferation rate (Figures 2(b) and 2(c)) in the LAPTM5-overexpression group were higher than that in controls, indicating that LAPTM5 promoted cell proliferation in ccRCC.
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PMC11786704
GSEA analysis of the MAPK gene set in diabetic mouse models. (
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PMC9429973
To date, successful single-agent ibrutinib retreatment responses are observed.
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PMC6182045
The reduced heterogeneity in glycan structure and protein pI, facilitated downstream purification by allowing the use of ion exchange chromatography strategies similar to those described previously (16, 38).
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PMC9429973
An additional 3 SF mut patients had improvements in blood counts but not lasting 8 weeks (ANC n=2, platelets n=1) and one with platelet improvement but a baseline not meeting IWG criteria (plt avg=108k prior to C1D1).
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PMC10170482
Indeed, it became evident that external mechanical forces regulate the cellular shape.
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PMC11682172
Fifty-thousand endothelial cells were plated on the upper chamber of the inserts and the cultures were placed in the incubator for three days.
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PMC11731161
Human multiple myeloma cell lines, including MM.1S, NCI-H929, U266 and RPMI-8226, were obtained from the American Type Culture Collection (ATCC) and have been cryopreserved at the Renji Blood Research Laboratory.
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PMC10808409
The faster release profile of TPGS mixed micelles (O2) as compared to the optimized mixed micelles (O1) during the first hour, could be due to the fact that TPGS is a hydrophilic surfactant which helps water to enter into the micelles core, forming more hydrophilic channels, thus allowing faster release of the entrapped drug.
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PMC9429973
Summary/Conclusion: The main risk factor for severe COVID-19 and death in patients with hematologic malignancies was lack of remission of the underlying disease.
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PMC11534377
SK-MES-1 cell line was cultured in medium with 10% FBS.
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PMC9429973
Under low oxygen saturation, HbS forms hemoglobin polymers that deform the red blood cell structure, referred to as ‘sickling’.
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PMC11718817
Imaging of macrophages and T cells in tumor spheroids demonstrated consistent patterns of migration.
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PMC11283030
Similar results were observed in 786-O and A498 cells treated with ACLY inhibitor HCA (Fig. S6b).
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PMC11604015
Target antigens for T cell-derived malignancies can be divided into antigens that cover all T cells and antigens limited to a subset of T cells.
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PMC11467800
Previously, we reported an APS as a mechanism for tyrosine kinase inhibitor (TKI) resistance in the chronic myeloid leukaemia (CML) cell line K562.
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PMC8494202
However, patients with glioblastoma generally use chemoradiotherapy, so there is a risk factor in univariate analysis.
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PMC9429973
Results: Pre-PMF patients exhibited higher leukocyte counts[14.2(6.0-28.1)×109/L vs 9.6(4.0-55.0)×109/L, P=0.003], LDH values[307(233-479)U/L vs 241(129-1182)U/L, P<0.001], onset ages[67(32-76)years vs 50(16-79) years, P=0.006], a higher frequen-cy of splenomegaly(47.4% vs 16.7%, P=0.018) and hypertension(57.9% vs 23.2%, P=0.005) than ET patients.
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PMC8728081
K10 indicates 10 ppm Kajjali, K20 indicates 20 ppm Kajjali and so on.
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PMC10291556
Notably, doxorubicin investigated in this study as positive control exhibited slightly less pronounced levels of phagocytosis, suggesting very effective stimulation of immune cells by the cancer cells treated with the Pt-complexes.
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PMC11697703
Only Stubby spines significantly increased after miR-193b-miR-365 expression with respect to miR-Cnt-double.
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PMC11792766
The first exposure lasted 4 h, followed by replacement with medium containing 4.5 µg/mL Cytochalasin B. The second exposure followed the same schedule but included 1% v/v S9 mix in the medium.
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PMC11783017
The pore diameter of the hydrogels in the porous structure shown in 3%PAMB-G-TK/1.5%PEG-SG was measured to be approximately 6 μm.
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PMC11036064
Then, we aimed to study the effect of hsa-miR-34a-5p ectopic expression and combined therapy on the apoptosis of A172 cells.
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PMC11742864
However, therapeutic resistance toward these drugs is a critical problem contributing to poor outcomes.
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PMC11012313
When the PF-4708671 inhibitor was added to block p70 S6K, the levels of HIF-1α were decreased in comparison to LMP2A-expressing cell lines incubated in the absence of an inhibitor (Figure 4B,C), suggesting that p70 S6K contributes to the LMP2A-mediated increase in HIF-1α.
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PMC11218145
injections of 5 × 10 luciferase transduced Ren cells in 0.5 mL of DMEM medium.
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PMC10158546
Membrane-associated GPI-anchored PrP is required for prion replication in vitro and is required for neuroinvasion and neuronal spread of PrP in vivo .
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PMC9341513
Two micrograms of cDNA reaction were amplified with SYBR green master mix (Invitrogen), 10 µM forward and reverse primers for LTO1, TPCN2, CCND1, and MYEOV (Sigma-Aldrich) with 40 cycles of PCR (95°C for 15 sec, 60°C for 60 sec) after initial denaturation (95°C for 10 min).
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PMC11805741
In contrast, sorafenib exhibited a stronger binding affinity with a ΔG of -5.53 kcal/mol (Suganya and Anuradha 2019).
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PMC8316344
The conjugation of TFRC-Myc by Ub-HA was measured by IB using anti-HA antibodies in the immunoprecipitates that immunoprecipitated by anti-Myc antibodies.
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PMC11574271
Upon the tumor volume reaching ~100 mm (~14 days), mice were divided into 2 groups.
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PMC11761919
n=3, *p < 0.05, **p < 0.01, ***p < 0.001.
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PMC11587606
We investigated whether a similar mechanism was applicable in RHBDF1-promoted PKCζ translocation into the nucleus.
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PMC9429973
Figure 1: Fold reduction in viral load after a single treatment with anti-SARS-COV2 containing plasma.
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PMC7185206
These supernatants were then centrifuged according to existing protocols and analyzed using an A50-Micro Plus Nanoscale Flow Cytometer (Apogee FlowSystems) gating for mid-intensity light angle light scatter (LALS) and marker of interest.
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PMC9429973
The estimated 9-year overall survival (OS) and failure-free survival (FFS) were 87.1±2.5% and 89.3±3.7% (P = 0.173) and 86.5±2.6% vs. 88.1±3.8% (P = 0.257) for patients in the HID and ISD SCT groups, respectively.
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PMC11703992
Meanwhile, the package derives posterior probabilities for five hypotheses (H0, H1, H2, H3, H4) after colocalization analysis to identify whether an SNP is shared between exposure and outcome.
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PMC3730428
XIAP is the only IAP that directly inhibits caspases: XIAP binds to caspases 3 and 7 via the region between its BIR1 and BIR2 domains and via the BIR2 domain itself, thereby directly inhibiting caspase activity.
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PMC10213179
To further confirm specificity for EphA2-expressing tumor cells, a pull-down assay was performed with biotinylated ATOP and SCR control aptamer using cell extracts from A673 cells.
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PMC11782780
These results indicated a specific downregulation of EBF3 in BC.
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PMC10421378
All temperatures were high enough to provide stability and long shelf-life, and they are compared with the temperatures obtained using TG/DTA in Table 1.
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PMC11486946
Quantification of the band densities was carried out using ImageJ software (NIH).
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PMC11026382
P values were calculated as in (a); the multiple-hypothesis testing adjusted p-value for the R166Q background was (P = 0.029).
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PMC11675244
The IWP (“Inhibitor of Wnt production”) molecule has been shown to disrupt this process, demonstrating significant effects in gastric cancer .
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PMC10006224
Means and SD are plotted.
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PMC11206502
It is responsible for the degradation of cytoplasmic content and the cell’s response to stress, embryonic development, pathogens, and aging.
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PMC11720808
As shown in Figure 1C and D, compared with the 0 μM group, the number of fluorescent cells decreased significantly in the SCU group (P < 0.01).
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