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BioData-CellLine_annotated

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PMC11679033
On the same slides, parameters of cell proliferation, cytostasis and cytotoxicity were studied, according to recommendations by OECD 2023 .
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PMC8526701
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodeling agents that can regulate genomic structure and DNA accessibility, thereby enabling timely and appropriate control of gene expression .
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PMC11742290
This review discusses the current literature on the expression and functional roles of LGR5 in cancers and chemotherapy resistance and highlights strategies to inhibit LGR5 in cancer.
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PMC11787355
The data were handled with Seurat (5.0.3).
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PMC11012313
Initial findings indicated that EBNA1, which is found in all stages of latency can positively regulate HIF-1α transcription in epithelial cell lines .
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PMC10932641
The occurrence and development of cancer are often closely related to the activation of oncogenes, the inactivation of tumor-suppressor genes, and abnormal changes in signaling pathways.
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PMC11762280
GSDMD-FL GSDMD full length.
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PMC4659567
H NMR (CDCl3, ppm): δ 11.12 (s, N1–H, 1H), 8.78 (d, J = 5.1, C6–H, 1H), 7.99 (d, J = 7.8, C4–H, 1H), 7.29 (s, C2–H, 1H), 7.21 (t, J = 6.3, C5–H, 1H), 5.60 (d, J = 5.5, C13–H, C15–H, 2H), 5.31 (d, J = 5.5, C12–H, C16–H, 2H), 2.95 (sep, J = 7.0, C17–H, 1H), 1.85 (s, C20–H, 3H), 1.30 (d, J = 7.0, C18–H, C19–H, 6H).
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PMC11348300
Fig. 4B presents the key findings of this study.
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PMC10932641
lncRNA CRNDE can promote tumor metastasis by activating the epithelial-mesenchymal transition (EMT) process through sponging miR-136-5p (30).
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PMC10631132
A–H Following hematopoietic differentiation of PBMC-derived iPSCs A–D or fibroblast-derived iPSCs (E–H), either according to an embryoid body based (EB) A, B, E, F or a monolayer-based (MB) protocol (C, D, G, H), hematopoietic cells were matured with M-CSF and differentiated into OCs with RANKL on calcium-phosphate coated wells.
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PMC9780037
One of these groups consists in enclosing cyt c inside pockets formed by large molecular structures that can target cancer cells and release cyt c into the cytoplasm, inducing their apoptosis (Figure 3B).
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PMC9672323
Despite these treatments, the disease correlates with a poor prognosis, with a median life expectancy of 15 months in the patients.
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PMC11539788
GSEA plots depicting the enrichment of the mTOR signalling pathway in samples with low RNF19A expression. (
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PMC11377827
The translucent pellet was washed in 1 ml of SDS buffer (16,000×g for 5 min).
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PMC11487720
However, POD was retarded at 37 °C under both conditions (Fig. 2K, L).
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PMC9100622
The statistical evaluation of Mevalonate pathway expression was performed with two-tailed unpaired Student’s t-tests with Welch’s correction.
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PMC10523483
Spearman Correlation of H1C with IC50 of cisplatin in NSCLC cell lines.
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PMC10940855
Disease burden was quantified on the basis of human CD138 (and mouse CD45) cells in the BM at 8 weeks and by quantification of PB human lambda light-chain levels over time.
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PMC9429973
Image: Summary/Conclusion: This study demonstrates that the BME environment as well as survival of pre-leukemic Pax5 mice is differently affected by LCMV infection supporting the observations that immune dysregulation could contribute to the emergence of the leukemic clone.
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PMC9024365
We identified the transmembrane protein synapse differentiation-induced gene 1 (SynDIG1; SD1) as an AMPAR interacting protein that regulates excitatory synaptic strength and AMPAR number both in vitro and in vivo.
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PMC6600592
The organic phase was dried with anhydrous sodium sulfate, and evaporated to give a crude product.
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PMC9822769
Interestingly enough, the increasing σ-donor ability of the equatorial nonleaving N-ligands (NH3 < NH2R < NHR2) trans to chlorides improves such a hydrolysis .
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PMC11470381
Each point corresponds to F/B value at a specific time frame of a single moving cell.
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PMC11546117
Differentiation medium was added to the receptor compartment, and the donor solution was added to the donor compartment to obtain a final concentration of 50 µM of each probe substrate in differentiation medium (0.2% DMSO).
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PMC10957991
P < 0.001 (t-test, two-sample equal variance). (
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PMC9429973
Among the 10 pts with ND-AML (5 de novo, 3 AML-MRC, 2 treated-secondary), 3 had extramedullary disease (EMD).
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PMC11092382
Using a rat model of transient focal cerebral ischemia, sophocarpine was shown to ameliorate brain damage, as indicated by reduced infarction and apoptosis, accompanied by improved neurological scores.
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PMC11298021
The assay relies on the ability of Annexin V, a calcium-dependent phospholipid-binding protein, to bind specifically to phosphatidylserine (PS) that is exposed on the outer surface of the plasma membrane during early stages of apoptosis.
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PMC6684588
ACE-083 and FST315-Fc were serially diluted in blocking buffer (0–60 nM) and applied to the plate in triplicate (200 μl).
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PMC10196713
It was also found that cisplatin-induced lipid peroxidation in OVK18 cells was inhibited by treatment with rotenone (Fig. 4D).
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PMC8992508
The study of these compounds on the MDCK II BCRP cell line, using the Hoechst 33342 accumulation assay, revealed that for BCRP a bioisosteric substitution of the tetrazole moiety is not beneficial as well as the modification of the amide in ortho-position.
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PMC11495567
In Black and White Americans, KRAS mutations are found with similar frequencies .
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PMC11389534
The anti‐pathogen or anti‐tumour reactivity of T cells is defined by their unique T‐cell receptors (TCRs), which can recognise specific antigens presented by human leukocyte antigen (HLA) complex.
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PMC9429973
Group 2 (n=263) were HR by validated risk score, had FLT3-ITD without an NPM1 mutation, had refractory disease and were randomised after induction course 1.
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PMC11541409
Understanding these drug-resistance mechanisms is crucial for developing more effective treatment methods.
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PMC11551844
The average diameter of the AuNPs-JDH, AuNPs-JDE and AuNPs-JC-2 was 21.1 ± 3.0 nm, 20.7 ± 2.1 nm and 26.2 ± 1.2 nm, respectively (Fig. 3C), and was less than the average diameter of the control (28.3 ± 3.4 nm).
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PMC11791478
For cervical PDX, XB002-treated mice were also euthanized if the individual MTV was ≥3,000 mm or the MTV for the group was ≥2,000 mm.
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PMC11680049
In particular, it was observed in the stems of Linum usitatissimum L., Populus trichocarpa L., and Corchorus capsularis L. .
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PMC9676986
Since the structural mechanism of FGFRs is complicated and a variety of structural variants occur in cancers, the elucidation of the structures of FGFR variants is critical for properly using inhibitors.
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PMC9275501
Li et al. (2017c) prepared Tf-modified DTX and BCL loaded solid lipid nanoparticles (Tf-D/B-SLNs) for lung cancer combined chemotherapy, which had better antitumor efficiency than unmodified SLNs and single drug loaded SLNs.
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PMC11473750
c Top panel: Cell viability analysis of SK-N-BE(2)-C and Kelly cells transfected with either Flag-RNF121, Flag-RNF121 or Empty vector control for 72 h. Two-sided unpaired Student’s t-tests were performed to derive p-values. *
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PMC11087055
Suppression of the Wnt/PCP pathway generates a wider and shorter PS while maintaining the polonaise movements.
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PMC11487720
The cells exhibited similar profiles in POD.
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PMC11747949
CCL2 is known as an enhancer of matrix metalloproteinase‐9 (MMP‐9) expression and cancer cell migration through CCR2 and activator protein‐1 (AP‐1) activation resulting in higher grade of the tumor (Liu et al. 2020).
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PMC10823017
We chose these doses to treat the cells as part of a combination therapy with BYL719 (10.0 µM).
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PMC9429973
A higher incidence was observed in patients >70 years (82%; p-value 0.19) and it was no impact on survival or TRM.
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PMC7582629
Finally, correlative imaging methods combining RM with other microscopies, such as optical coherence tomography (OCT), holography, fluorescence microscopy and mass-spectroscopy-based imaging, for a full understanding of the morphology and cell biochemistry, are described.
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PMC11224020
We found that LmnA/C DCs did not upregulate CCR7 expression nor translocate cPLA2 into the nucleus when confined at a height of 3 µm (Fig. 4e,f).
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PMC11757230
Animals were handled in accordance with the animal care guidelines of the Institute of Laboratory Animal Resources of Nippon Veterinary and Life Science University, which conform to national and international guidelines, including the ARRIVE guidelines.
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PMC9895440
Statistics are pairwise 2-way ANOVAs followed by Bonferroni correction.
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PMC10890307
Immediately, the volume of media present in each well was measured to account for evaporation in the analysis of metabolites.
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PMC11699465
In this article, we report the nuclear localization of TMEM199 protein and further illustrate its function in mediating tumor immune microenvironment by regulating PD-L1 mRNA levels.
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PMC9429973
Besides known targets, significant breakpoints were identified in genes previously not implicated in B-lymphomagenesis such as TOX and TP73 (36% and 21%).
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PMC8358176
mL on 96- and/or 6-well plates for subsequent experiments.
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PMC10998613
From these results, we conclude that CXCR4 is primarily a dimer in COS-7 cells, while in MDA-MB-231 cells at similarly high expression levels, CXCR4 is a multimer (oligomers on the order of trimers and tetramers).
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PMC11129910
These results are consistent with the migration ability of the transformed positive control cell line, RAO-4, and together confirm one of the properties seen in cells that have transformed.
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PMC10936243
That has happened before.
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PMC11621565
Controls were established in triplicate for each experiment with dopaminergic-differentiated SH-SY5Y cells incubated with the solvent of the treatment (vehicle-only controls).
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PMC9516447
Validation of the anti-Ras antibodies used in this study was performed through the use of siRNA molecules specifically targeting each Ras protein, correlating with reduction of the specific RAS protein band in Western blot (Suppl.
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PMC8414691
Cytosolic fraction (2 mg/ml) from subcellular fractionation assay (see the next paragraph) was used as input (IN).
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PMC11322866
Cells were treated with 10 μM CHX for 0, 12, or 24 h. Protein expression level of EZH2 was measured by western blot analysis.
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PMC11754094
Unfortunately, high-fidelity Cas9 nuclease does not overcome the issue of unintended large deletions that occur at on-target sites.
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PMC11721587
Subsequent SUMO-SIM–mediated interaction promotes Fu/Ulk3 polymerization to form biomolecular condensates (Fig. 8).
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PMC8345486
The original images were archived in nd2 format and converted to jpg.
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PMC11085211
Approximately a 30% viability reduction was observed in the FR3-treated sample (p < 0.05), while FR1 promoted no effect.
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PMC11530949
According to the results of this test, Ephedra intermedia is a good stabilizing and reducing reagent for doped the Ag-doped CuO NPs synthesis.
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PMC9019892
GIST‐T1 and GIST‐882 cell lines were treated with imatinib for 4 h to activate FGF/FGFR signalling pathway, after which imatinib was removed and the cells were treated with nintedanib for 4 h for immunoblotting analysis.
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PMC10926885
Furthermore, we noted that there was also a trend that lower NDE1 expression levels were associated with longer OS or DFS in patients with BLCA, CESC, COAD, DLBC, KICH, KIRP, LUSC, PAAD, SARC and UVM, although no statistical significance was observed (Figure S1).
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PMC11607638
Female mosquitoes were fed a blood meal 24 hours after injection of dsRNA and mosquito heads were excised six hours after the blood meal for qPCR analysis.
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PMC11588085
We also observed that the specific mesenchymal marker NES was down-regulated in hypoxia compared to normoxia and to the same extent for sgCtl, sgXIST7, and sgXIST9 (SI Appendix, Fig. S6A), confirming the transition from M-CSC to E-CSC under hypoxia.
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PMC3765139
Additionally, CD133 expression was also detected in sections of a primary human melanoma (Figure 6B) and a lymph node metastasis (Figure 6E) but hardly in normal skin sections (Figure 6A).
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PMC4443654
Random forest models summarized the important relationships among these many variables, providing insights into the quantitative contributions of locus-level chromatin features to higher-order structures.
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PMC11321678
Additionally, GFAP is an undifferentiated marker of MB cells.
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PMC11643361
Triple-negative breast cancer (TNBC) is characterized by the absence of three key receptors in cancer cells—estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)—making TNBC more difficult to treat.
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PMC11470381
Add 2 mL of media per well.
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PMC8916024
Paired-end clean reads were merged as raw tags using FLASH (V.1.2.11) with a minimum overlap of 10 bp and mismatch error rate of 2% (Salzberg, 2011).
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PMC10988555
As shown in Figure S13, it is possible to identify the three isoforms of the pDNA (nicked, linear, and supercoiled) for all the combinations tested.
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PMC11473750
Neuroblastoma cell line LAN-1 was kindly provided by Dr. John Maris (Children’s Hospital of Philadelphia, Philadelphia, USA).
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PMC11723210
This will provide strong support for subsequent cell morphology and cell mass analysis.
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PMC11538390
Data are represented as mean values +/− s.d.
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PMC9429973
Physical examination revealed hepatosplenomegal and no adenomegalies.
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PMC5415764
The results were expressed as relative protein levels compared to the relative total protein ± SD of three independent experiments.
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PMC10170482
ColF (green) fluorescent probe labels specifically collagen fibers.
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PMC10870498
The KIF23 expression was upregulated in ATC cells.
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PMC2118063
In addition, transcripts for CD38, IRF4, PRDM1, and XBP1 were highest in plasma cells.
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PMC11756514
The BV421 signal was measured by flow cytometry using the NovoCyte 3000 flow cytometer and analyzed using FlowJO 10, where GFP-positive events were gated as bacteria.
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PMC9429973
The obtained clinical data do not make it possible to identify associations of a particular SARS-CoV-2 variant with the course of the disease.
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PMC10723784
Statistical analyses were carried out using Graph pad 7, one‐way ANOVA with Dennett's multi‐comparison test.
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PMC7812570
Statistical comparisons were conducted by ANOVA (**P < 0.01; ***P < 0.001) In this study, we continued to explore novel strategies to effectively create HIV-resistant cells.
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PMC11566417
However, despite the recognized effectiveness of antibiotics in combatting infections, they are not designed to address the negative consequences of tissue damage due to host immune responses or bacterial immune evasion strategies.
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PMC9429973
Of note, in this TP, MRD-BM by MFC was 0.011%.
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PMC11126803
Diaminobenzidine chromogen showed immunoreactivity, and slides were counterstained in hematoxylin, dehydrated, cleared, and permanently mounted with resin mounting medium (Thermo Fisher Scientific) (60).
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PMC9027909
P value < 0.05; ** P value < 0.01; *** P value < 0.001; **** P value < 0.0001.
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PMC11525028
For acRIP-seq, RNA was extracted using TRIzol (Invitrogen) as mentioned above and mRNA was enriched with Poly(A)Purist MAG Kit (Invitrogen, AM1922) according to the manufacturer’s instructions.
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PMC11670407
These results suggest that OTULIN stabilized GPX4 independently of protein synthesis.
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PMC7185206
Notably, PD-L1 protein-to-mRNA ratio did not correlate with survival in patients with lung cancer in The Cancer Genome Atlas dataset (Supplemental Figure 1b).
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PMC9856122
The complex inhibits S protein-ACE2 binding as compared to single BBR and ZnO-NP .
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PMC11594806
The mechanisms driving FN-RMS pathogenesis are not well understood, but CD73 was identified as a TWIST2-regulated gene involved in FN-RMS development.
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PMC8358176
Multi-walled CNTs (MWCNTs) are comprised of multiple SWCNTs stacked one inside another, and their diameters can range up to 100 nm.
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